yourlist:M2015071097E05OJGPJ	Entry	Entry name	Status	Protein names	Gene names	Organism	Length	Gene ontology (GO)	Gene ontology (biological process)	Gene ontology (molecular function)	Gene ontology (cellular component)	Gene ontology IDs	Subcellular location [CC]	Keywords	Features
PABP2_HUMAN	Q86U42	PABP2_HUMAN	reviewed	Polyadenylate-binding protein 2 (PABP-2) (Poly(A)-binding protein 2) (Nuclear poly(A)-binding protein 1) (Poly(A)-binding protein II) (PABII) (Polyadenylate-binding nuclear protein 1)	PABPN1 PAB2 PABP2	Homo sapiens (Human)	306	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]; nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; gene expression [GO:0010467]; modification by virus of host mRNA processing [GO:0046778]; modulation by virus of host morphology or physiology [GO:0019048]; modulation by virus of host process [GO:0019054]; mRNA 3'-end processing [GO:0031124]; mRNA splicing, via spliceosome [GO:0000398]; muscle contraction [GO:0006936]; poly(A)+ mRNA export from nucleus [GO:0016973]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]; termination of RNA polymerase II transcription [GO:0006369]; transcription from RNA polymerase II promoter [GO:0006366]; viral life cycle [GO:0019058]	gene expression [GO:0010467]; modification by virus of host mRNA processing [GO:0046778]; modulation by virus of host morphology or physiology [GO:0019048]; modulation by virus of host process [GO:0019054]; mRNA 3'-end processing [GO:0031124]; mRNA splicing, via spliceosome [GO:0000398]; muscle contraction [GO:0006936]; poly(A)+ mRNA export from nucleus [GO:0016973]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]; termination of RNA polymerase II transcription [GO:0006369]; transcription from RNA polymerase II promoter [GO:0006366]; viral life cycle [GO:0019058]	nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]	GO:0003723; GO:0006396; GO:0008380; GO:0005737; GO:0010467; GO:0031124; GO:0000398; GO:0046778; GO:0019048; GO:0019054; GO:0006936; GO:0005654; GO:0000166; GO:0005634; GO:0044822; GO:0016973; GO:0030529; GO:0006369; GO:0006366; GO:0019058	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:10688363, ECO:0000269|PubMed:11001936, ECO:0000269|PubMed:14663186, ECO:0000269|PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between the nucleus and the cytoplasm but predominantly found in the nucleus. Its nuclear import may involve the nucleocytoplasmic transport receptor transportin and a RAN-GTP-sensitive import mechanism. Is exported to the cytoplasm by a carrier-mediated pathway that is independent of mRNA traffic. Nucleus; nuclear speckle. Colocalizes with SKIP and poly(A) RNA in nuclear speckles (By similarity). {ECO:0000250}.	3D-structure; Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Methylation; Nucleus; Phosphoprotein; Polymorphism; RNA-binding; Reference proteome; Triplet repeat expansion; mRNA processing	Alternative sequence (2); Beta strand (5); Chain (1); Coiled coil (1); Compositional bias (1); Domain (1); Erroneous initiation (1); Helix (5); Initiator methionine (1); Modified residue (21); Mutagenesis (2); Natural variant (1); Region (4); Turn (1)
EIF3J_HUMAN	O75822	EIF3J_HUMAN	reviewed	Eukaryotic translation initiation factor 3 subunit J (eIF3j) (Eukaryotic translation initiation factor 3 subunit 1) (eIF-3-alpha) (eIF3 p35)	EIF3J EIF3S1 PRO0391	Homo sapiens (Human)	258	cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; translation initiation factor activity [GO:0003743]; cellular protein metabolic process [GO:0044267]; cytoplasmic translation [GO:0002181]; formation of translation preinitiation complex [GO:0001731]; gene expression [GO:0010467]; regulation of translational initiation [GO:0006446]; translation [GO:0006412]; translational initiation [GO:0006413]	cellular protein metabolic process [GO:0044267]; cytoplasmic translation [GO:0002181]; formation of translation preinitiation complex [GO:0001731]; gene expression [GO:0010467]; regulation of translational initiation [GO:0006446]; translation [GO:0006412]; translational initiation [GO:0006413]	translation initiation factor activity [GO:0003743]	cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]	GO:0044267; GO:0002181; GO:0005829; GO:0016282; GO:0033290; GO:0005852; GO:0001731; GO:0010467; GO:0006446; GO:0006412; GO:0003743; GO:0006413	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03009}.	3D-structure; Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Initiation factor; Phosphoprotein; Polymorphism; Protein biosynthesis; Reference proteome	Alternative sequence (2); Chain (1); Coiled coil (1); Compositional bias (4); Helix (4); Initiator methionine (1); Mass spectrometry (2); Modified residue (7); Natural variant (1); Region (2); Sequence conflict (1); Turn (1)
MK01_HUMAN	P28482	MK01_HUMAN	reviewed	Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)	MAPK1 ERK2 PRKM1 PRKM2	Homo sapiens (Human)	360	axon [GO:0030424]; caveola [GO:0005901]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; mitochondrion [GO:0005739]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; protein complex [GO:0043234]; pseudopodium [GO:0031143]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; MAP kinase activity [GO:0004707]; phosphatase binding [GO:0019902]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II carboxy-terminal domain kinase activity [GO:0008353]; activation of MAPK activity [GO:0000187]; activation of MAPKK activity [GO:0000186]; apoptotic process [GO:0006915]; axon guidance [GO:0007411]; B cell receptor signaling pathway [GO:0050853]; blood coagulation [GO:0007596]; caveolin-mediated endocytosis [GO:0072584]; cell cycle [GO:0007049]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to heat [GO:0034605]; chemotaxis [GO:0006935]; cytosine metabolic process [GO:0019858]; epidermal growth factor receptor signaling pathway [GO:0007173]; ERBB signaling pathway [GO:0038127]; ERK1 and ERK2 cascade [GO:0070371]; Fc-epsilon receptor signaling pathway [GO:0038095]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; fibroblast growth factor receptor signaling pathway [GO:0008543]; innate immune response [GO:0045087]; insulin receptor signaling pathway [GO:0008286]; JAK-STAT cascade involved in growth hormone signaling pathway [GO:0060397]; labyrinthine layer blood vessel development [GO:0060716]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; mammary gland epithelial cell proliferation [GO:0033598]; MAPK cascade [GO:0000165]; MAPK import into nucleus [GO:0000189]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; MyD88-independent toll-like receptor signaling pathway [GO:0002756]; negative regulation of cell differentiation [GO:0045596]; neurotrophin TRK receptor signaling pathway [GO:0048011]; organ morphogenesis [GO:0009887]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; platelet activation [GO:0030168]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation [GO:0008284]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of translation [GO:0045727]; protein phosphorylation [GO:0006468]; Ras protein signal transduction [GO:0007265]; regulation of cellular response to heat [GO:1900034]; regulation of cytoskeleton organization [GO:0051493]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of Golgi inheritance [GO:0090170]; regulation of protein stability [GO:0031647]; regulation of sequence-specific DNA binding transcription factor activity [GO:0051090]; regulation of stress-activated MAPK cascade [GO:0032872]; response to epidermal growth factor [GO:0070849]; response to estrogen [GO:0043627]; response to exogenous dsRNA [GO:0043330]; response to stress [GO:0006950]; response to toxic substance [GO:0009636]; sensory perception of pain [GO:0019233]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]; stress-activated MAPK cascade [GO:0051403]; synaptic transmission [GO:0007268]; T cell receptor signaling pathway [GO:0050852]; toll-like receptor 10 signaling pathway [GO:0034166]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 5 signaling pathway [GO:0034146]; toll-like receptor 9 signaling pathway [GO:0034162]; toll-like receptor signaling pathway [GO:0002224]; toll-like receptor TLR1:TLR2 signaling pathway [GO:0038123]; toll-like receptor TLR6:TLR2 signaling pathway [GO:0038124]; transcription, DNA-templated [GO:0006351]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; viral process [GO:0016032]	activation of MAPK activity [GO:0000187]; activation of MAPKK activity [GO:0000186]; apoptotic process [GO:0006915]; axon guidance [GO:0007411]; B cell receptor signaling pathway [GO:0050853]; blood coagulation [GO:0007596]; caveolin-mediated endocytosis [GO:0072584]; cell cycle [GO:0007049]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to heat [GO:0034605]; chemotaxis [GO:0006935]; cytosine metabolic process [GO:0019858]; epidermal growth factor receptor signaling pathway [GO:0007173]; ERBB signaling pathway [GO:0038127]; ERK1 and ERK2 cascade [GO:0070371]; Fc-epsilon receptor signaling pathway [GO:0038095]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; fibroblast growth factor receptor signaling pathway [GO:0008543]; innate immune response [GO:0045087]; insulin receptor signaling pathway [GO:0008286]; JAK-STAT cascade involved in growth hormone signaling pathway [GO:0060397]; labyrinthine layer blood vessel development [GO:0060716]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; mammary gland epithelial cell proliferation [GO:0033598]; MAPK cascade [GO:0000165]; MAPK import into nucleus [GO:0000189]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; MyD88-independent toll-like receptor signaling pathway [GO:0002756]; negative regulation of cell differentiation [GO:0045596]; neurotrophin TRK receptor signaling pathway [GO:0048011]; organ morphogenesis [GO:0009887]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; platelet activation [GO:0030168]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation [GO:0008284]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of translation [GO:0045727]; protein phosphorylation [GO:0006468]; Ras protein signal transduction [GO:0007265]; regulation of cellular response to heat [GO:1900034]; regulation of cytoskeleton organization [GO:0051493]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of Golgi inheritance [GO:0090170]; regulation of protein stability [GO:0031647]; regulation of sequence-specific DNA binding transcription factor activity [GO:0051090]; regulation of stress-activated MAPK cascade [GO:0032872]; response to epidermal growth factor [GO:0070849]; response to estrogen [GO:0043627]; response to exogenous dsRNA [GO:0043330]; response to stress [GO:0006950]; response to toxic substance [GO:0009636]; sensory perception of pain [GO:0019233]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]; stress-activated MAPK cascade [GO:0051403]; synaptic transmission [GO:0007268]; T cell receptor signaling pathway [GO:0050852]; toll-like receptor 10 signaling pathway [GO:0034166]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 5 signaling pathway [GO:0034146]; toll-like receptor 9 signaling pathway [GO:0034162]; toll-like receptor signaling pathway [GO:0002224]; toll-like receptor TLR1:TLR2 signaling pathway [GO:0038123]; toll-like receptor TLR6:TLR2 signaling pathway [GO:0038124]; transcription, DNA-templated [GO:0006351]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; viral process [GO:0016032]	ATP binding [GO:0005524]; DNA binding [GO:0003677]; MAP kinase activity [GO:0004707]; phosphatase binding [GO:0019902]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II carboxy-terminal domain kinase activity [GO:0008353]	axon [GO:0030424]; caveola [GO:0005901]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; mitochondrion [GO:0005739]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; protein complex [GO:0043234]; pseudopodium [GO:0031143]	GO:0005524; GO:0050853; GO:0003677; GO:0038127; GO:0070371; GO:0038095; GO:0038096; GO:0005794; GO:0060397; GO:0004707; GO:0000165; GO:0000189; GO:0002755; GO:0002756; GO:0008353; GO:0007265; GO:0050852; GO:0035666; GO:0000187; GO:0000186; GO:0006915; GO:0030424; GO:0007411; GO:0007596; GO:0005901; GO:0072584; GO:0007049; GO:0006974; GO:0097011; GO:0034605; GO:0006935; GO:0005737; GO:0019858; GO:0005856; GO:0005829; GO:0032839; GO:0005769; GO:0007173; GO:0070062; GO:0008543; GO:0005925; GO:0045087; GO:0008286; GO:0060716; GO:0005770; GO:0031663; GO:0033598; GO:0015630; GO:0005815; GO:0005739; GO:0072686; GO:0045596; GO:0048011; GO:0005654; GO:0005634; GO:0009887; GO:0018105; GO:0018107; GO:0043204; GO:0019902; GO:0030168; GO:0030335; GO:0008284; GO:0010800; GO:0045893; GO:0045727; GO:0043234; GO:0006468; GO:0004674; GO:0031143; GO:0090170; GO:1900034; GO:0051493; GO:2000641; GO:0031647; GO:0051090; GO:0032872; GO:0070849; GO:0043627; GO:0043330; GO:0006950; GO:0009636; GO:0019233; GO:0007165; GO:0007264; GO:0051403; GO:0007268; GO:0034166; GO:0034134; GO:0034138; GO:0034142; GO:0034146; GO:0034162; GO:0038123; GO:0038124; GO:0002224; GO:0006351; GO:0048010; GO:0016032	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Note=Associated with the spindle during prometaphase and metaphase (By similarity). PEA15-binding and phosphorylated DAPK1 promote its cytoplasmic retention. Phosphorylation at Ser- 246 and Ser-248 as well as autophosphorylation at Thr-190 promote nuclear localization. {ECO:0000250}.	3D-structure; ATP-binding; Acetylation; Alternative splicing; Apoptosis; Cell cycle; Complete proteome; Cytoplasm; Cytoskeleton; DNA-binding; Direct protein sequencing; Host-virus interaction; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Repressor; Serine/threonine-protein kinase; Transcription; Transcription regulation; Transferase; Ubl conjugation	Active site (1); Alternative sequence (1); Beta strand (13); Binding site (7); Chain (1); Compositional bias (1); DNA binding (1); Domain (1); Erroneous initiation (1); Helix (19); Initiator methionine (1); Modified residue (8); Motif (3); Mutagenesis (8); Nucleotide binding (1); Region (2); Sequence conflict (1); Turn (9)
DHPR_HUMAN	P09417	DHPR_HUMAN	reviewed	Dihydropteridine reductase (EC 1.5.1.34) (HDHPR) (Quinoid dihydropteridine reductase) (Short chain dehydrogenase/reductase family 33C member 1)	QDPR DHPR SDR33C1	Homo sapiens (Human)	244	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; 6,7-dihydropteridine reductase activity [GO:0004155]; electron carrier activity [GO:0009055]; NADH binding [GO:0070404]; NADPH binding [GO:0070402]; cellular amino acid metabolic process [GO:0006520]; cellular nitrogen compound metabolic process [GO:0034641]; cellular response to drug [GO:0035690]; dihydrobiopterin metabolic process [GO:0051066]; L-phenylalanine catabolic process [GO:0006559]; liver development [GO:0001889]; response to aluminum ion [GO:0010044]; response to glucagon [GO:0033762]; response to lead ion [GO:0010288]; small molecule metabolic process [GO:0044281]; tetrahydrobiopterin biosynthetic process [GO:0006729]	cellular amino acid metabolic process [GO:0006520]; cellular nitrogen compound metabolic process [GO:0034641]; cellular response to drug [GO:0035690]; dihydrobiopterin metabolic process [GO:0051066]; liver development [GO:0001889]; L-phenylalanine catabolic process [GO:0006559]; response to aluminum ion [GO:0010044]; response to glucagon [GO:0033762]; response to lead ion [GO:0010288]; small molecule metabolic process [GO:0044281]; tetrahydrobiopterin biosynthetic process [GO:0006729]	6,7-dihydropteridine reductase activity [GO:0004155]; electron carrier activity [GO:0009055]; NADH binding [GO:0070404]; NADPH binding [GO:0070402]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]	GO:0004155; GO:0006559; GO:0070404; GO:0070402; GO:0006520; GO:0034641; GO:0035690; GO:0005737; GO:0005829; GO:0051066; GO:0009055; GO:0070062; GO:0001889; GO:0005739; GO:0043005; GO:0010044; GO:0033762; GO:0010288; GO:0044281; GO:0006729		3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Disease mutation; NADP; Oxidoreductase; Phenylketonuria; Polymorphism; Reference proteome; Tetrahydrobiopterin biosynthesis	Active site (1); Alternative sequence (1); Beta strand (8); Chain (1); Helix (9); Initiator methionine (1); Modified residue (5); Natural variant (19); Nucleotide binding (1); Turn (2)
WRIP1_HUMAN	Q96S55	WRIP1_HUMAN	reviewed	ATPase WRNIP1 (EC 3.6.1.3) (Werner helicase-interacting protein 1)	WRNIP1 WHIP	Homo sapiens (Human)	665	membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; DNA replication [GO:0006260]; DNA synthesis involved in DNA repair [GO:0000731]; regulation of DNA-dependent DNA replication initiation [GO:0030174]	DNA replication [GO:0006260]; DNA synthesis involved in DNA repair [GO:0000731]; regulation of DNA-dependent DNA replication initiation [GO:0030174]	ATPase activity [GO:0016887]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]	membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]	GO:0005524; GO:0016887; GO:0003677; GO:0006260; GO:0000731; GO:0042802; GO:0016020; GO:0046872; GO:0005634; GO:0048471; GO:0030174	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Colocalizes with WRN in granular structures in the nucleus. {ECO:0000250}.	3D-structure; ATP-binding; Acetylation; Alternative splicing; Complete proteome; DNA damage; DNA replication; Hydrolase; Isopeptide bond; Metal-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation; Zinc; Zinc-finger	Alternative sequence (3); Beta strand (2); Chain (1); Cross-link (12); Erroneous initiation (2); Helix (2); Modified residue (9); Nucleotide binding (1); Sequence conflict (8); Turn (1); Zinc finger (1)
DPOE4_HUMAN	Q9NR33	DPOE4_HUMAN	reviewed	DNA polymerase epsilon subunit 4 (EC 2.7.7.7) (DNA polymerase II subunit 4) (DNA polymerase epsilon subunit p12)	POLE4	Homo sapiens (Human)	117	Ada2/Gcn5/Ada3 transcription activator complex [GO:0005671]; epsilon DNA polymerase complex [GO:0008622]; nucleus [GO:0005634]; DNA-directed DNA polymerase activity [GO:0003887]; sequence-specific DNA binding [GO:0043565]; DNA biosynthetic process [GO:0071897]; histone H3 acetylation [GO:0043966]	DNA biosynthetic process [GO:0071897]; histone H3 acetylation [GO:0043966]	DNA-directed DNA polymerase activity [GO:0003887]; sequence-specific DNA binding [GO:0043565]	Ada2/Gcn5/Ada3 transcription activator complex [GO:0005671]; epsilon DNA polymerase complex [GO:0008622]; nucleus [GO:0005634]	GO:0005671; GO:0071897; GO:0003887; GO:0008622; GO:0043966; GO:0005634; GO:0043565	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.	Acetylation; Complete proteome; DNA-binding; DNA-directed DNA polymerase; Nucleotidyltransferase; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transferase	Chain (1); Initiator methionine (1); Modified residue (3); Natural variant (1)
SCFD1_HUMAN	Q8WVM8	SCFD1_HUMAN	reviewed	Sec1 family domain-containing protein 1 (SLY1 homolog) (Sly1p) (Syntaxin-binding protein 1-like 2)	SCFD1 C14orf163 KIAA0917 STXBP1L2 FKSG23	Homo sapiens (Human)	642	cis-Golgi network [GO:0005801]; endoplasmic reticulum membrane [GO:0005789]; Golgi cisterna membrane [GO:0032580]; Golgi transport complex [GO:0017119]; Golgi-associated vesicle [GO:0005798]; plasma membrane [GO:0005886]; syntaxin binding [GO:0019905]; cell morphogenesis [GO:0000902]; negative regulation of autophagic vacuole assembly [GO:1902902]; phagocytosis [GO:0006909]; post-Golgi vesicle-mediated transport [GO:0006892]; protein transport [GO:0015031]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; regulation of protein transport [GO:0051223]; response to hypoxia [GO:0001666]; response to toxic substance [GO:0009636]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]; vesicle docking involved in exocytosis [GO:0006904]	cell morphogenesis [GO:0000902]; negative regulation of autophagic vacuole assembly [GO:1902902]; phagocytosis [GO:0006909]; post-Golgi vesicle-mediated transport [GO:0006892]; protein transport [GO:0015031]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; regulation of protein transport [GO:0051223]; response to hypoxia [GO:0001666]; response to toxic substance [GO:0009636]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]; vesicle docking involved in exocytosis [GO:0006904]	syntaxin binding [GO:0019905]	cis-Golgi network [GO:0005801]; endoplasmic reticulum membrane [GO:0005789]; Golgi-associated vesicle [GO:0005798]; Golgi cisterna membrane [GO:0032580]; Golgi transport complex [GO:0017119]; plasma membrane [GO:0005886]	GO:0032580; GO:0017119; GO:0005798; GO:0000902; GO:0005801; GO:0005789; GO:1902902; GO:0006909; GO:0005886; GO:0006892; GO:0015031; GO:0060628; GO:0051223; GO:0001666; GO:0009636; GO:0006890; GO:0019905; GO:0006904	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Golgi apparatus, Golgi stack membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.	Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; ER-Golgi transport; Endoplasmic reticulum; Golgi apparatus; Membrane; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport	Alternative sequence (2); Chain (1); Compositional bias (1); Erroneous initiation (1); Frameshift (3); Initiator methionine (1); Modified residue (2); Natural variant (1); Sequence conflict (10)
IPO5_HUMAN	O00410	IPO5_HUMAN	reviewed	Importin-5 (Imp5) (Importin subunit beta-3) (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5)	IPO5 KPNB3 RANBP5	Homo sapiens (Human)	1097	cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; GTPase inhibitor activity [GO:0005095]; poly(A) RNA binding [GO:0044822]; protein transporter activity [GO:0008565]; Ran GTPase binding [GO:0008536]; cellular response to amino acid stimulus [GO:0071230]; negative regulation of GTPase activity [GO:0034260]; NLS-bearing protein import into nucleus [GO:0006607]; positive regulation of protein import into nucleus [GO:0042307]; ribosomal protein import into nucleus [GO:0006610]; viral process [GO:0016032]	cellular response to amino acid stimulus [GO:0071230]; negative regulation of GTPase activity [GO:0034260]; NLS-bearing protein import into nucleus [GO:0006607]; positive regulation of protein import into nucleus [GO:0042307]; ribosomal protein import into nucleus [GO:0006610]; viral process [GO:0016032]	GTPase inhibitor activity [GO:0005095]; poly(A) RNA binding [GO:0044822]; protein transporter activity [GO:0008565]; Ran GTPase binding [GO:0008536]	cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005095; GO:0005794; GO:0006607; GO:0008536; GO:0071230; GO:0005737; GO:0043231; GO:0016020; GO:0034260; GO:0031965; GO:0005643; GO:0005730; GO:0005654; GO:0005634; GO:0044822; GO:0042307; GO:0008565; GO:0006610; GO:0016032	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Nucleus; nuclear rim. Found particularly in the nuclear rim and nucleolus.	Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Host-virus interaction; Nucleus; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Repeat; Transport	Alternative sequence (2); Chain (1); Compositional bias (2); Domain (1); Frameshift (2); Initiator methionine (1); Modified residue (2); Natural variant (5); Region (1); Repeat (24); Sequence conflict (2)
SUGT1_HUMAN	Q9Y2Z0	SUGT1_HUMAN	reviewed	Suppressor of G2 allele of SKP1 homolog (Protein 40-6-3) (Sgt1)	SUGT1	Homo sapiens (Human)	365	cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; innate immune response [GO:0045087]; mitotic nuclear division [GO:0007067]; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [GO:0035872]; positive regulation by host of symbiont catalytic activity [GO:0043947]	innate immune response [GO:0045087]; mitotic nuclear division [GO:0007067]; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [GO:0035872]; positive regulation by host of symbiont catalytic activity [GO:0043947]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	GO:0005737; GO:0005829; GO:0045087; GO:0000776; GO:0007067; GO:0035872; GO:0005634; GO:0043947; GO:0000151	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21864708}. Nucleus {ECO:0000269|PubMed:21864708}. Note=Translocates to the nucleus upon heat shock, requiring S100A6.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome; Repeat; TPR repeat; Ubl conjugation pathway	Alternative sequence (1); Beta strand (10); Chain (1); Domain (2); Helix (2); Initiator methionine (1); Modified residue (4); Repeat (3); Sequence conflict (1)
GET4_HUMAN	Q7L5D6	GET4_HUMAN	reviewed	Golgi to ER traffic protein 4 homolog (Conserved edge-expressed protein) (Transmembrane domain recognition complex 35 kDa subunit) (TRC35)	GET4 C7orf20 CEE TRC35 CGI-20	Homo sapiens (Human)	327	BAT3 complex [GO:0071818]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytoplasmic sequestering of protein [GO:0051220]; positive regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903071]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]; transport [GO:0006810]	cytoplasmic sequestering of protein [GO:0051220]; positive regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903071]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]; transport [GO:0006810]		BAT3 complex [GO:0071818]; cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0071818; GO:0005737; GO:0051220; GO:0005829; GO:1903071; GO:0071816; GO:0006810	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:20676083}.	Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Reference proteome; Transport	Alternative sequence (1); Chain (1); Initiator methionine (1); Modified residue (1); Sequence conflict (2)
MK03_HUMAN	P27361	MK03_HUMAN	reviewed	Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1)	MAPK3 ERK1 PRKM3	Homo sapiens (Human)	379	caveola [GO:0005901]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; microtubule cytoskeleton [GO:0015630]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pseudopodium [GO:0031143]; ATP binding [GO:0005524]; MAP kinase activity [GO:0004707]; phosphatase binding [GO:0019902]; activation of MAPK activity [GO:0000187]; activation of MAPKK activity [GO:0000186]; apoptotic process [GO:0006915]; axon guidance [GO:0007411]; blood coagulation [GO:0007596]; BMP signaling pathway [GO:0030509]; cartilage development [GO:0051216]; caveolin-mediated endocytosis [GO:0072584]; cell cycle [GO:0007049]; cellular response to heat [GO:0034605]; cellular response to mechanical stimulus [GO:0071260]; cytokine-mediated signaling pathway [GO:0019221]; DNA damage induced protein phosphorylation [GO:0006975]; epidermal growth factor receptor signaling pathway [GO:0007173]; Fc-epsilon receptor signaling pathway [GO:0038095]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; fibroblast growth factor receptor signaling pathway [GO:0008543]; gene expression [GO:0010467]; innate immune response [GO:0045087]; insulin receptor signaling pathway [GO:0008286]; interleukin-1-mediated signaling pathway [GO:0070498]; JAK-STAT cascade involved in growth hormone signaling pathway [GO:0060397]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; MAPK cascade [GO:0000165]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; MyD88-independent toll-like receptor signaling pathway [GO:0002756]; negative regulation of apolipoprotein binding [GO:2000657]; neurotrophin TRK receptor signaling pathway [GO:0048011]; organ morphogenesis [GO:0009887]; peptidyl-tyrosine autophosphorylation [GO:0038083]; phosphorylation [GO:0016310]; platelet activation [GO:0030168]; positive regulation of cyclase activity [GO:0031281]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of histone acetylation [GO:0035066]; positive regulation of histone phosphorylation [GO:0033129]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein phosphorylation [GO:0006468]; Ras protein signal transduction [GO:0007265]; regulation of cellular response to heat [GO:1900034]; regulation of cytoskeleton organization [GO:0051493]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of Golgi inheritance [GO:0090170]; regulation of sequence-specific DNA binding transcription factor activity [GO:0051090]; regulation of stress-activated MAPK cascade [GO:0032872]; response to epidermal growth factor [GO:0070849]; response to exogenous dsRNA [GO:0043330]; sensory perception of pain [GO:0019233]; small GTPase mediated signal transduction [GO:0007264]; stress-activated MAPK cascade [GO:0051403]; toll-like receptor 10 signaling pathway [GO:0034166]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 5 signaling pathway [GO:0034146]; toll-like receptor 9 signaling pathway [GO:0034162]; toll-like receptor signaling pathway [GO:0002224]; toll-like receptor TLR1:TLR2 signaling pathway [GO:0038123]; toll-like receptor TLR6:TLR2 signaling pathway [GO:0038124]; transcription from RNA polymerase I promoter [GO:0006360]; transcription initiation from RNA polymerase I promoter [GO:0006361]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; viral process [GO:0016032]	activation of MAPK activity [GO:0000187]; activation of MAPKK activity [GO:0000186]; apoptotic process [GO:0006915]; axon guidance [GO:0007411]; blood coagulation [GO:0007596]; BMP signaling pathway [GO:0030509]; cartilage development [GO:0051216]; caveolin-mediated endocytosis [GO:0072584]; cell cycle [GO:0007049]; cellular response to heat [GO:0034605]; cellular response to mechanical stimulus [GO:0071260]; cytokine-mediated signaling pathway [GO:0019221]; DNA damage induced protein phosphorylation [GO:0006975]; epidermal growth factor receptor signaling pathway [GO:0007173]; Fc-epsilon receptor signaling pathway [GO:0038095]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; fibroblast growth factor receptor signaling pathway [GO:0008543]; gene expression [GO:0010467]; innate immune response [GO:0045087]; insulin receptor signaling pathway [GO:0008286]; interleukin-1-mediated signaling pathway [GO:0070498]; JAK-STAT cascade involved in growth hormone signaling pathway [GO:0060397]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; MAPK cascade [GO:0000165]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; MyD88-independent toll-like receptor signaling pathway [GO:0002756]; negative regulation of apolipoprotein binding [GO:2000657]; neurotrophin TRK receptor signaling pathway [GO:0048011]; organ morphogenesis [GO:0009887]; peptidyl-tyrosine autophosphorylation [GO:0038083]; phosphorylation [GO:0016310]; platelet activation [GO:0030168]; positive regulation of cyclase activity [GO:0031281]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of histone acetylation [GO:0035066]; positive regulation of histone phosphorylation [GO:0033129]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein phosphorylation [GO:0006468]; Ras protein signal transduction [GO:0007265]; regulation of cellular response to heat [GO:1900034]; regulation of cytoskeleton organization [GO:0051493]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of Golgi inheritance [GO:0090170]; regulation of sequence-specific DNA binding transcription factor activity [GO:0051090]; regulation of stress-activated MAPK cascade [GO:0032872]; response to epidermal growth factor [GO:0070849]; response to exogenous dsRNA [GO:0043330]; sensory perception of pain [GO:0019233]; small GTPase mediated signal transduction [GO:0007264]; stress-activated MAPK cascade [GO:0051403]; toll-like receptor 10 signaling pathway [GO:0034166]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 5 signaling pathway [GO:0034146]; toll-like receptor 9 signaling pathway [GO:0034162]; toll-like receptor signaling pathway [GO:0002224]; toll-like receptor TLR1:TLR2 signaling pathway [GO:0038123]; toll-like receptor TLR6:TLR2 signaling pathway [GO:0038124]; transcription from RNA polymerase I promoter [GO:0006360]; transcription initiation from RNA polymerase I promoter [GO:0006361]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; viral process [GO:0016032]	ATP binding [GO:0005524]; MAP kinase activity [GO:0004707]; phosphatase binding [GO:0019902]	caveola [GO:0005901]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; microtubule cytoskeleton [GO:0015630]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pseudopodium [GO:0031143]	GO:0005524; GO:0030509; GO:0006975; GO:0038095; GO:0038096; GO:0005794; GO:0060397; GO:0004707; GO:0000165; GO:0002755; GO:0002756; GO:0007265; GO:0035666; GO:0000187; GO:0000186; GO:0006915; GO:0007411; GO:0007596; GO:0051216; GO:0005901; GO:0072584; GO:0007049; GO:0034605; GO:0071260; GO:0019221; GO:0005856; GO:0005829; GO:0005769; GO:0007173; GO:0070062; GO:0008543; GO:0005925; GO:0010467; GO:0045087; GO:0008286; GO:0070498; GO:0005770; GO:0031663; GO:0015630; GO:0005739; GO:2000657; GO:0048011; GO:0005635; GO:0005654; GO:0005634; GO:0009887; GO:0038083; GO:0019902; GO:0016310; GO:0030168; GO:0070374; GO:0031281; GO:0035066; GO:0033129; GO:0001934; GO:0045944; GO:0006468; GO:0031143; GO:0090170; GO:1900034; GO:0051493; GO:2000641; GO:0051090; GO:0032872; GO:0070849; GO:0043330; GO:0019233; GO:0007264; GO:0051403; GO:0034166; GO:0034134; GO:0034138; GO:0034142; GO:0034146; GO:0034162; GO:0038123; GO:0038124; GO:0002224; GO:0006360; GO:0006361; GO:0048010; GO:0016032	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Autophosphorylation at Thr-207 promotes nuclear localization.	3D-structure; ATP-binding; Acetylation; Alternative splicing; Apoptosis; Cell cycle; Complete proteome; Cytoplasm; Direct protein sequencing; Host-virus interaction; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase	Active site (1); Alternative sequence (2); Beta strand (10); Binding site (1); Chain (1); Domain (1); Helix (20); Initiator methionine (1); Modified residue (5); Motif (1); Natural variant (1); Nucleotide binding (1); Sequence conflict (2); Turn (5)
TRI32_HUMAN	Q13049	TRI32_HUMAN	reviewed	E3 ubiquitin-protein ligase TRIM32 (EC 6.3.2.-) (72 kDa Tat-interacting protein) (Tripartite motif-containing protein 32) (Zinc finger protein HT2A)	TRIM32 HT2A	Homo sapiens (Human)	653	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; striated muscle myosin thick filament [GO:0005863]; ligase activity [GO:0016874]; myosin binding [GO:0017022]; protein self-association [GO:0043621]; RNA binding [GO:0003723]; Tat protein binding [GO:0030957]; transcription coactivator activity [GO:0003713]; translation initiation factor binding [GO:0031369]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; fat cell differentiation [GO:0045444]; innate immune response [GO:0045087]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of viral release from host cell [GO:1902187]; negative regulation of viral transcription [GO:0032897]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell motility [GO:2000147]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of neurogenesis [GO:0050769]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of proteolysis [GO:0045862]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of type I interferon production [GO:0032481]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of type I interferon production [GO:0032479]; response to tumor necrosis factor [GO:0034612]; response to UV [GO:0009411]	fat cell differentiation [GO:0045444]; innate immune response [GO:0045087]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of viral release from host cell [GO:1902187]; negative regulation of viral transcription [GO:0032897]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell motility [GO:2000147]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of neurogenesis [GO:0050769]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of proteolysis [GO:0045862]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of type I interferon production [GO:0032481]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of type I interferon production [GO:0032479]; response to tumor necrosis factor [GO:0034612]; response to UV [GO:0009411]	ligase activity [GO:0016874]; myosin binding [GO:0017022]; protein self-association [GO:0043621]; RNA binding [GO:0003723]; Tat protein binding [GO:0030957]; transcription coactivator activity [GO:0003713]; translation initiation factor binding [GO:0031369]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; striated muscle myosin thick filament [GO:0005863]	GO:0003723; GO:0030957; GO:0005737; GO:0005829; GO:0045444; GO:0045087; GO:0016874; GO:0017022; GO:0048147; GO:1902230; GO:1902187; GO:0032897; GO:0005634; GO:0043123; GO:0051092; GO:0045787; GO:0030307; GO:0030335; GO:2000147; GO:0050769; GO:0045666; GO:0045732; GO:0045862; GO:0051091; GO:0032481; GO:0000209; GO:0043621; GO:0016567; GO:0042787; GO:0032479; GO:0009411; GO:0034612; GO:0005863; GO:0003713; GO:0031369; GO:0043130; GO:0061630; GO:0004842; GO:0008270	SUBCELLULAR LOCATION: Cytoplasm. Note=Localized in cytoplasmic bodies, often located around the nucleus.	3D-structure; Acetylation; Bardet-Biedl syndrome; Ciliopathy; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Ligase; Limb-girdle muscular dystrophy; Mental retardation; Metal-binding; Obesity; Polymorphism; Reference proteome; Repeat; Ubl conjugation; Ubl conjugation pathway; Zinc; Zinc-finger	Beta strand (4); Chain (1); Coiled coil (1); Compositional bias (1); Helix (1); Initiator methionine (1); Modified residue (1); Natural variant (7); Repeat (5); Sequence conflict (1); Turn (4); Zinc finger (2)
DNJC7_HUMAN	Q99615	DNJC7_HUMAN	reviewed	DnaJ homolog subfamily C member 7 (Tetratricopeptide repeat protein 2) (TPR repeat protein 2)	DNAJC7 TPR2 TTC2	Homo sapiens (Human)	494	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; heat shock protein binding [GO:0031072]; cellular response to heat [GO:0034605]; chaperone cofactor-dependent protein refolding [GO:0070389]; protein folding [GO:0006457]; regulation of cellular response to heat [GO:1900034]	cellular response to heat [GO:0034605]; chaperone cofactor-dependent protein refolding [GO:0070389]; protein folding [GO:0006457]; regulation of cellular response to heat [GO:1900034]	heat shock protein binding [GO:0031072]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]	GO:0034605; GO:0070389; GO:0005737; GO:0005856; GO:0005829; GO:0070062; GO:0031072; GO:0016020; GO:0005654; GO:0006457; GO:1900034	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Note=Colocalizes with NR1I3 to microtubules. {ECO:0000250}.	Acetylation; Alternative splicing; Chaperone; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Nucleus; Reference proteome; Repeat; TPR repeat	Alternative sequence (1); Chain (1); Domain (1); Erroneous initiation (2); Initiator methionine (1); Modified residue (1); Mutagenesis (3); Repeat (9); Sequence conflict (1)
BL1S2_HUMAN	Q6QNY1	BL1S2_HUMAN	reviewed	Biogenesis of lysosome-related organelles complex 1 subunit 2 (BLOC-1 subunit 2) (Centrosome-associated protein)	BLOC1S2 BLOS2 CEAP	Homo sapiens (Human)	142	BLOC-1 complex [GO:0031083]; centrosome [GO:0005813]; gamma-tubulin complex [GO:0000930]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; recycling endosome [GO:0055037]; gamma-tubulin binding [GO:0043015]; protein C-terminus binding [GO:0008022]; anterograde axon cargo transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; melanosome organization [GO:0032438]; microtubule nucleation [GO:0007020]; mitochondrial outer membrane permeabilization [GO:0097345]; neuron projection development [GO:0031175]; platelet dense granule organization [GO:0060155]; positive regulation of cell proliferation [GO:0008284]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]	anterograde axon cargo transport [GO:0008089]; anterograde synaptic vesicle transport [GO:0048490]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; melanosome organization [GO:0032438]; microtubule nucleation [GO:0007020]; mitochondrial outer membrane permeabilization [GO:0097345]; neuron projection development [GO:0031175]; platelet dense granule organization [GO:0060155]; positive regulation of cell proliferation [GO:0008284]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]	gamma-tubulin binding [GO:0043015]; protein C-terminus binding [GO:0008022]	BLOC-1 complex [GO:0031083]; centrosome [GO:0005813]; gamma-tubulin complex [GO:0000930]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; recycling endosome [GO:0055037]	GO:0031083; GO:0008089; GO:0048490; GO:0005813; GO:0008625; GO:0043015; GO:0000930; GO:0032438; GO:0007020; GO:0097345; GO:0005739; GO:0031175; GO:0005634; GO:0060155; GO:0008284; GO:0045944; GO:0045893; GO:0008022; GO:0055037	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15381421}. Note=Localizes to the centrosomes in a microtubule-dependent manner.	Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Polymorphism; Reference proteome	Alternative sequence (1); Chain (1); Coiled coil (1); Erroneous gene model prediction (2); Erroneous initiation (1); Initiator methionine (1); Modified residue (1); Natural variant (1)
MCA3_HUMAN	O43324	MCA3_HUMAN	reviewed	Eukaryotic translation elongation factor 1 epsilon-1 (Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3) (Elongation factor p18) (Multisynthase complex auxiliary component p18)	EEF1E1 AIMP3 P18	Homo sapiens (Human)	174	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; gene expression [GO:0010467]; negative regulation of cell proliferation [GO:0008285]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; tRNA aminoacylation for protein translation [GO:0006418]	gene expression [GO:0010467]; negative regulation of cell proliferation [GO:0008285]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; tRNA aminoacylation for protein translation [GO:0006418]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	GO:0005737; GO:0005829; GO:0070062; GO:0010467; GO:0008285; GO:0005634; GO:0043517; GO:0043065; GO:0006418	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15680327}. Nucleus {ECO:0000269|PubMed:15680327}. Note=Cytoplasmic under growth arrest conditions. Translocated into the nucleus when growth resumes (S phase) and following DNA damage.	3D-structure; Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Protein biosynthesis; Reference proteome	Alternative sequence (1); Beta strand (4); Chain (1); Coiled coil (1); Domain (1); Helix (9); Initiator methionine (1); Modified residue (2); Region (3); Turn (3)
D3YTC9_HUMAN	D3YTC9	D3YTC9_HUMAN	unreviewed	Ankyrin repeat domain-containing protein 54	ANKRD54	Homo sapiens (Human)	284							ANK repeat; Complete proteome; Proteomics identification; Reference proteome; Repeat	
ARHL2_HUMAN	Q9NX46	ARHL2_HUMAN	reviewed	Poly(ADP-ribose) glycohydrolase ARH3 (EC 3.2.1.143) (ADP-ribosylhydrolase 3) ([Protein ADP-ribosylarginine] hydrolase-like protein 2)	ADPRHL2 ARH3	Homo sapiens (Human)	363	mitochondrial matrix [GO:0005759]; nucleoplasm [GO:0005654]; metal ion binding [GO:0046872]; poly(ADP-ribose) glycohydrolase activity [GO:0004649]; cellular response to superoxide [GO:0071451]	cellular response to superoxide [GO:0071451]	metal ion binding [GO:0046872]; poly(ADP-ribose) glycohydrolase activity [GO:0004649]	mitochondrial matrix [GO:0005759]; nucleoplasm [GO:0005654]	GO:0071451; GO:0046872; GO:0005759; GO:0005654; GO:0004649	SUBCELLULAR LOCATION: Cytoplasm. Mitochondrion matrix. Nucleus.	3D-structure; Complete proteome; Cytoplasm; Hydrolase; Magnesium; Metal-binding; Mitochondrion; Nucleus; Polymorphism; Reference proteome; Transit peptide	Beta strand (2); Binding site (1); Chain (1); Compositional bias (1); Frameshift (1); Helix (22); Metal binding (8); Mutagenesis (13); Natural variant (1); Sequence conflict (1); Transit peptide (1); Turn (2)
NU188_HUMAN	Q5SRE5	NU188_HUMAN	reviewed	Nucleoporin NUP188 homolog (hNup188)	NUP188 KIAA0169	Homo sapiens (Human)	1749	membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; carbohydrate metabolic process [GO:0005975]; cellular protein metabolic process [GO:0044267]; cellular response to heat [GO:0034605]; cytokine-mediated signaling pathway [GO:0019221]; gene expression [GO:0010467]; glucose transport [GO:0015758]; hexose transport [GO:0008645]; mitotic cell cycle [GO:0000278]; mitotic nuclear envelope disassembly [GO:0007077]; mRNA transport [GO:0051028]; post-translational protein modification [GO:0043687]; protein sumoylation [GO:0016925]; protein transport [GO:0015031]; regulation of cellular response to heat [GO:1900034]; regulation of glucose transport [GO:0010827]; small molecule metabolic process [GO:0044281]; transmembrane transport [GO:0055085]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	carbohydrate metabolic process [GO:0005975]; cellular protein metabolic process [GO:0044267]; cellular response to heat [GO:0034605]; cytokine-mediated signaling pathway [GO:0019221]; gene expression [GO:0010467]; glucose transport [GO:0015758]; hexose transport [GO:0008645]; mitotic cell cycle [GO:0000278]; mitotic nuclear envelope disassembly [GO:0007077]; mRNA transport [GO:0051028]; post-translational protein modification [GO:0043687]; protein sumoylation [GO:0016925]; protein transport [GO:0015031]; regulation of cellular response to heat [GO:1900034]; regulation of glucose transport [GO:0010827]; small molecule metabolic process [GO:0044281]; transmembrane transport [GO:0055085]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]		membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]	GO:0005975; GO:0044267; GO:0034605; GO:0019221; GO:0010467; GO:0015758; GO:0008645; GO:0051028; GO:0016020; GO:0000278; GO:0007077; GO:0005635; GO:0005643; GO:0043687; GO:0016925; GO:0015031; GO:1900034; GO:0010827; GO:0044281; GO:0055085; GO:0019058; GO:0016032; GO:0019083	SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000305}.	Acetylation; Alternative splicing; Complete proteome; Nuclear pore complex; Nucleus; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Translocation; Transport; mRNA transport	Alternative sequence (1); Chain (1); Erroneous initiation (1); Initiator methionine (1); Modified residue (5); Natural variant (2); Sequence conflict (3)
DHSO_HUMAN	Q00796	DHSO_HUMAN	reviewed	Sorbitol dehydrogenase (EC 1.1.1.14) (L-iditol 2-dehydrogenase)	SORD	Homo sapiens (Human)	357	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; motile cilium [GO:0031514]; carbohydrate binding [GO:0030246]; L-iditol 2-dehydrogenase activity [GO:0003939]; NAD binding [GO:0051287]; zinc ion binding [GO:0008270]; carbohydrate metabolic process [GO:0005975]; fructose biosynthetic process [GO:0046370]; fructose metabolic process [GO:0006000]; glucose metabolic process [GO:0006006]; L-xylitol catabolic process [GO:0051160]; L-xylitol metabolic process [GO:0051164]; small molecule metabolic process [GO:0044281]; sorbitol catabolic process [GO:0006062]; sperm motility [GO:0030317]	carbohydrate metabolic process [GO:0005975]; fructose biosynthetic process [GO:0046370]; fructose metabolic process [GO:0006000]; glucose metabolic process [GO:0006006]; L-xylitol catabolic process [GO:0051160]; L-xylitol metabolic process [GO:0051164]; small molecule metabolic process [GO:0044281]; sorbitol catabolic process [GO:0006062]; sperm motility [GO:0030317]	carbohydrate binding [GO:0030246]; L-iditol 2-dehydrogenase activity [GO:0003939]; NAD binding [GO:0051287]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; motile cilium [GO:0031514]	GO:0003939; GO:0051160; GO:0051164; GO:0051287; GO:0030246; GO:0005975; GO:0005829; GO:0070062; GO:0005615; GO:0046370; GO:0006000; GO:0006006; GO:0016020; GO:0031966; GO:0031514; GO:0044281; GO:0006062; GO:0030317; GO:0008270	SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250|UniProtKB:Q64442}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q64442}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q64442}. Note=Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface. {ECO:0000250|UniProtKB:Q64442}.	3D-structure; Acetylation; Alternative splicing; Cell projection; Cilium; Complete proteome; Direct protein sequencing; Flagellum; Membrane; Metal-binding; Mitochondrion; NAD; Oxidoreductase; Phosphoprotein; Polymorphism; Reference proteome; Zinc	Alternative sequence (2); Beta strand (17); Binding site (4); Chain (1); Helix (14); Initiator methionine (1); Metal binding (3); Modified residue (3); Natural variant (2); Sequence conflict (5)
B4DHR0_HUMAN	B4DHR0	B4DHR0_HUMAN	unreviewed	Rab GTPase-binding effector protein 2 (cDNA FLJ57369, highly similar to Rab GTPase-binding effector protein 2)	RABEP2	Homo sapiens (Human)	498	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; GTPase activator activity [GO:0005096]; endocytosis [GO:0006897]	endocytosis [GO:0006897]	GTPase activator activity [GO:0005096]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]	GO:0005096; GO:0005737; GO:0006897; GO:0043231		Complete proteome; Proteomics identification; Reference proteome	
RABE2_HUMAN	Q9H5N1	RABE2_HUMAN	reviewed	Rab GTPase-binding effector protein 2 (Rabaptin-5beta)	RABEP2 RABPT5B	Homo sapiens (Human)	569	cytoplasm [GO:0005737]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; GTPase activator activity [GO:0005096]; endocytosis [GO:0006897]; protein transport [GO:0015031]	endocytosis [GO:0006897]; protein transport [GO:0015031]	GTPase activator activity [GO:0005096]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]	GO:0005096; GO:0005737; GO:0005769; GO:0006897; GO:0043231; GO:0015031	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9524116}. Early endosome {ECO:0000269|PubMed:9524116}.	Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Endocytosis; Endosome; Protein transport; Reference proteome; Transport	Alternative sequence (2); Chain (1); Coiled coil (2); Compositional bias (1); Frameshift (1); Initiator methionine (1); Modified residue (1)
LRC47_HUMAN	Q8N1G4	LRC47_HUMAN	reviewed	Leucine-rich repeat-containing protein 47	LRRC47 KIAA1185	Homo sapiens (Human)	583	poly(A) RNA binding [GO:0044822]		poly(A) RNA binding [GO:0044822]		GO:0044822		Acetylation; Coiled coil; Complete proteome; Direct protein sequencing; Leucine-rich repeat; Phosphoprotein; Polymorphism; Reference proteome; Repeat	Chain (1); Coiled coil (1); Compositional bias (1); Initiator methionine (1); Modified residue (5); Natural variant (3); Repeat (7)
ZFP91_HUMAN	Q96JP5	ZFP91_HUMAN	reviewed	E3 ubiquitin-protein ligase ZFP91 (EC 6.3.2.-) (Zinc finger protein 757) (Zinc finger protein 91 homolog) (Zfp-91)	ZFP91 ZNF757 FKSG11	Homo sapiens (Human)	570	nucleus [GO:0005634]; ligase activity [GO:0016874]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; ubiquitin-protein transferase activity [GO:0004842]; activation of NF-kappaB-inducing kinase activity [GO:0007250]; protein K63-linked ubiquitination [GO:0070534]	activation of NF-kappaB-inducing kinase activity [GO:0007250]; protein K63-linked ubiquitination [GO:0070534]	ligase activity [GO:0016874]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; ubiquitin-protein transferase activity [GO:0004842]	nucleus [GO:0005634]	GO:0007250; GO:0016874; GO:0046872; GO:0003676; GO:0005634; GO:0070534; GO:0004842	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12738986}.	3D-structure; Alternative splicing; Complete proteome; Direct protein sequencing; Ligase; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Ubl conjugation pathway; Zinc; Zinc-finger	Alternative sequence (2); Beta strand (4); Chain (1); Compositional bias (3); Frameshift (1); Helix (4); Initiator methionine (1); Modified residue (1); Mutagenesis (2); Natural variant (2); Region (1); Sequence conflict (2); Turn (1); Zinc finger (5)
MTHFS_HUMAN	P49914	MTHFS_HUMAN	reviewed	5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) (5,10-methenyl-tetrahydrofolate synthetase) (MTHFS) (Methenyl-THF synthetase)	MTHFS	Homo sapiens (Human)	203	cytoplasm [GO:0005737]; 5-formyltetrahydrofolate cyclo-ligase activity [GO:0030272]; ATP binding [GO:0005524]; folic acid binding [GO:0005542]; metal ion binding [GO:0046872]; formate metabolic process [GO:0015942]; tetrahydrofolate metabolic process [GO:0046653]	formate metabolic process [GO:0015942]; tetrahydrofolate metabolic process [GO:0046653]	5-formyltetrahydrofolate cyclo-ligase activity [GO:0030272]; ATP binding [GO:0005524]; folic acid binding [GO:0005542]; metal ion binding [GO:0046872]	cytoplasm [GO:0005737]	GO:0030272; GO:0005524; GO:0005737; GO:0005542; GO:0015942; GO:0046872; GO:0046653	SUBCELLULAR LOCATION: Cytoplasm.	3D-structure; ATP-binding; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Folate-binding; Ligase; Magnesium; Metal-binding; Nucleotide-binding; Polymorphism; Reference proteome	Alternative sequence (1); Beta strand (9); Binding site (3); Chain (1); Frameshift (1); Helix (8); Initiator methionine (1); Metal binding (2); Modified residue (1); Mutagenesis (6); Natural variant (1); Nucleotide binding (2); Region (1); Sequence conflict (2); Turn (2)
PSD11_HUMAN	O00231	PSD11_HUMAN	reviewed	26S proteasome non-ATPase regulatory subunit 11 (26S proteasome regulatory subunit RPN6) (26S proteasome regulatory subunit S9) (26S proteasome regulatory subunit p44.5)	PSMD11	Homo sapiens (Human)	422	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; proteasome assembly [GO:0043248]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stem cell differentiation [GO:0048863]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; ubiquitin-dependent protein catabolic process [GO:0006511]; viral process [GO:0016032]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; proteasome assembly [GO:0043248]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stem cell differentiation [GO:0048863]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; ubiquitin-dependent protein catabolic process [GO:0006511]; viral process [GO:0016032]		cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]	GO:0006977; GO:0000082; GO:0031145; GO:0042590; GO:0002479; GO:0002474; GO:0006915; GO:0034641; GO:0005829; GO:0070062; GO:0010467; GO:0045087; GO:0016020; GO:0000278; GO:0043066; GO:0090090; GO:0051436; GO:0005654; GO:0005634; GO:0090263; GO:0051437; GO:0012501; GO:0022624; GO:0043248; GO:0000502; GO:0005838; GO:0000209; GO:0042981; GO:0006521; GO:0051439; GO:0044281; GO:0048863; GO:0002223; GO:0006511; GO:0016032	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}.	Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Phosphoprotein; Proteasome; Reference proteome	Alternative sequence (1); Chain (1); Domain (1); Initiator methionine (1); Modified residue (2); Mutagenesis (3); Sequence conflict (1)
DDX31_HUMAN	Q9H8H2	DDX31_HUMAN	reviewed	Probable ATP-dependent RNA helicase DDX31 (EC 3.6.4.13) (DEAD box protein 31) (Helicain)	DDX31	Homo sapiens (Human)	851	Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; ATP binding [GO:0005524]; ATP-dependent RNA helicase activity [GO:0004004]; poly(A) RNA binding [GO:0044822]; RNA secondary structure unwinding [GO:0010501]	RNA secondary structure unwinding [GO:0010501]	ATP binding [GO:0005524]; ATP-dependent RNA helicase activity [GO:0004004]; poly(A) RNA binding [GO:0044822]	Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]	GO:0005524; GO:0004004; GO:0005794; GO:0010501; GO:0043231; GO:0005730; GO:0044822	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.	ATP-binding; Alternative splicing; Complete proteome; Helicase; Hydrolase; Nucleotide-binding; Nucleus; Polymorphism; RNA-binding; Reference proteome	Alternative sequence (4); Chain (1); Domain (2); Erroneous gene model prediction (2); Erroneous initiation (1); Frameshift (3); Motif (2); Natural variant (4); Nucleotide binding (1); Sequence conflict (4)
PGP_HUMAN	A6NDG6	PGP_HUMAN	reviewed	Phosphoglycolate phosphatase (PGP) (PGPase) (EC 3.1.3.18) (EC 3.1.3.48)	PGP	Homo sapiens (Human)	321	magnesium ion binding [GO:0000287]; nucleotide phosphatase activity, acting on free nucleotides [GO:0098519]; phosphoglycolate phosphatase activity [GO:0008967]; protein tyrosine phosphatase activity [GO:0004725]; carbohydrate metabolic process [GO:0005975]; dephosphorylation [GO:0016311]; peptidyl-tyrosine dephosphorylation [GO:0035335]	carbohydrate metabolic process [GO:0005975]; dephosphorylation [GO:0016311]; peptidyl-tyrosine dephosphorylation [GO:0035335]	magnesium ion binding [GO:0000287]; nucleotide phosphatase activity, acting on free nucleotides [GO:0098519]; phosphoglycolate phosphatase activity [GO:0008967]; protein tyrosine phosphatase activity [GO:0004725]		GO:0005975; GO:0016311; GO:0000287; GO:0098519; GO:0035335; GO:0008967; GO:0004725		Carbohydrate metabolism; Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome	Active site (2); Chain (1); Metal binding (3); Site (1)
E9PPB4_HUMAN	E9PPB4	E9PPB4_HUMAN	unreviewed	Peroxisomal biogenesis factor 19	PEX19	Homo sapiens (Human)	40							Complete proteome; Proteomics identification; Reference proteome	
P5CR3_HUMAN	Q53H96	P5CR3_HUMAN	reviewed	Pyrroline-5-carboxylate reductase 3 (P5C reductase 3) (P5CR 3) (EC 1.5.1.2) (Pyrroline-5-carboxylate reductase-like protein)	PYCRL	Homo sapiens (Human)	274	pyrroline-5-carboxylate reductase activity [GO:0004735]; L-proline biosynthetic process [GO:0055129]	L-proline biosynthetic process [GO:0055129]	pyrroline-5-carboxylate reductase activity [GO:0004735]		GO:0055129; GO:0004735		Acetylation; Alternative splicing; Amino-acid biosynthesis; Complete proteome; NADP; Oxidoreductase; Polymorphism; Proline biosynthesis; Reference proteome	Alternative sequence (1); Chain (1); Erroneous initiation (1); Initiator methionine (1); Modified residue (1); Natural variant (3); Sequence caution (1)
PRP4B_HUMAN	Q13523	PRP4B_HUMAN	reviewed	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog)	PRPF4B KIAA0536 PRP4 PRP4H PRP4K	Homo sapiens (Human)	1007	catalytic step 2 spliceosome [GO:0071013]; chromosome [GO:0005694]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; poly(A) RNA binding [GO:0044822]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; mRNA splicing, via spliceosome [GO:0000398]; protein phosphorylation [GO:0006468]; RNA splicing [GO:0008380]	mRNA splicing, via spliceosome [GO:0000398]; protein phosphorylation [GO:0006468]; RNA splicing [GO:0008380]	ATP binding [GO:0005524]; poly(A) RNA binding [GO:0044822]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]	catalytic step 2 spliceosome [GO:0071013]; chromosome [GO:0005694]; nucleoplasm [GO:0005654]	GO:0005524; GO:0008380; GO:0071013; GO:0005694; GO:0000398; GO:0005654; GO:0044822; GO:0004672; GO:0006468; GO:0004674	SUBCELLULAR LOCATION: Nucleus.	3D-structure; ATP-binding; Acetylation; Complete proteome; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Spliceosome; Transferase; mRNA processing; mRNA splicing	Active site (1); Beta strand (12); Binding site (1); Chain (1); Compositional bias (2); Domain (1); Erroneous initiation (1); Frameshift (1); Helix (15); Initiator methionine (1); Modified residue (37); Natural variant (3); Nucleotide binding (1); Sequence conflict (4); Turn (3)
FUMH_HUMAN	P07954	FUMH_HUMAN	reviewed	Fumarate hydratase, mitochondrial (Fumarase) (EC 4.2.1.2)	FH	Homo sapiens (Human)	510	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; tricarboxylic acid cycle enzyme complex [GO:0045239]; fumarate hydratase activity [GO:0004333]; cellular metabolic process [GO:0044237]; fumarate metabolic process [GO:0006106]; homeostasis of number of cells within a tissue [GO:0048873]; small molecule metabolic process [GO:0044281]; tricarboxylic acid cycle [GO:0006099]	cellular metabolic process [GO:0044237]; fumarate metabolic process [GO:0006106]; homeostasis of number of cells within a tissue [GO:0048873]; small molecule metabolic process [GO:0044281]; tricarboxylic acid cycle [GO:0006099]	fumarate hydratase activity [GO:0004333]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; tricarboxylic acid cycle enzyme complex [GO:0045239]	GO:0044237; GO:0005737; GO:0070062; GO:0004333; GO:0006106; GO:0048873; GO:0005759; GO:0005739; GO:0044281; GO:0006099; GO:0045239	SUBCELLULAR LOCATION: Isoform Mitochondrial: Mitochondrion.; SUBCELLULAR LOCATION: Isoform Cytoplasmic: Cytoplasm.	3D-structure; Acetylation; Alternative initiation; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Lyase; Mitochondrion; Phosphoprotein; Reference proteome; Transit peptide; Tricarboxylic acid cycle; Tumor suppressor	Alternative sequence (1); Beta strand (8); Binding site (1); Chain (1); Helix (24); Modified residue (21); Natural variant (11); Region (2); Transit peptide (1); Turn (4)
NU160_HUMAN	Q12769	NU160_HUMAN	reviewed	Nuclear pore complex protein Nup160 (160 kDa nucleoporin) (Nucleoporin Nup160)	NUP160 KIAA0197 NUP120	Homo sapiens (Human)	1436	cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080]; nucleocytoplasmic transporter activity [GO:0005487]; carbohydrate metabolic process [GO:0005975]; cellular protein metabolic process [GO:0044267]; cellular response to heat [GO:0034605]; cytokine-mediated signaling pathway [GO:0019221]; gene expression [GO:0010467]; glucose transport [GO:0015758]; hexose transport [GO:0008645]; mitotic cell cycle [GO:0000278]; mitotic nuclear envelope disassembly [GO:0007077]; mRNA export from nucleus [GO:0006406]; post-translational protein modification [GO:0043687]; protein sumoylation [GO:0016925]; protein transport [GO:0015031]; regulation of cellular response to heat [GO:1900034]; regulation of glucose transport [GO:0010827]; small GTPase mediated signal transduction [GO:0007264]; small molecule metabolic process [GO:0044281]; transmembrane transport [GO:0055085]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	carbohydrate metabolic process [GO:0005975]; cellular protein metabolic process [GO:0044267]; cellular response to heat [GO:0034605]; cytokine-mediated signaling pathway [GO:0019221]; gene expression [GO:0010467]; glucose transport [GO:0015758]; hexose transport [GO:0008645]; mitotic cell cycle [GO:0000278]; mitotic nuclear envelope disassembly [GO:0007077]; mRNA export from nucleus [GO:0006406]; post-translational protein modification [GO:0043687]; protein sumoylation [GO:0016925]; protein transport [GO:0015031]; regulation of cellular response to heat [GO:1900034]; regulation of glucose transport [GO:0010827]; small GTPase mediated signal transduction [GO:0007264]; small molecule metabolic process [GO:0044281]; transmembrane transport [GO:0055085]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	nucleocytoplasmic transporter activity [GO:0005487]	cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nuclear pore outer ring [GO:0031080]	GO:0005975; GO:0044267; GO:0034605; GO:0019221; GO:0005829; GO:0010467; GO:0015758; GO:0008645; GO:0006406; GO:0000278; GO:0007077; GO:0005635; GO:0005643; GO:0031080; GO:0005487; GO:0043687; GO:0016925; GO:0015031; GO:1900034; GO:0010827; GO:0007264; GO:0044281; GO:0055085; GO:0019058; GO:0016032; GO:0019083	SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000269|PubMed:11564755, ECO:0000269|PubMed:11684705}.	Alternative splicing; Complete proteome; Nuclear pore complex; Nucleus; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Translocation; Transport; mRNA transport	Alternative sequence (6); Chain (1); Erroneous initiation (3); Modified residue (1); Natural variant (2); Sequence caution (1); Sequence conflict (2)
ZN598_HUMAN	Q86UK7	ZN598_HUMAN	reviewed	Zinc finger protein 598	ZNF598	Homo sapiens (Human)	904	poly(A) RNA binding [GO:0044822]; zinc ion binding [GO:0008270]		poly(A) RNA binding [GO:0044822]; zinc ion binding [GO:0008270]		GO:0044822; GO:0008270		Alternative splicing; Complete proteome; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Zinc; Zinc-finger	Alternative sequence (6); Chain (1); Compositional bias (1); Erroneous initiation (1); Modified residue (2); Natural variant (4); Zinc finger (2)
RAB21_HUMAN	Q9UL25	RAB21_HUMAN	reviewed	Ras-related protein Rab-21	RAB21 KIAA0118	Homo sapiens (Human)	225	cleavage furrow [GO:0032154]; cytoplasmic side of early endosome membrane [GO:0098559]; cytoplasmic side of plasma membrane [GO:0009898]; cytoplasmic vesicle membrane [GO:0030659]; early endosome [GO:0005769]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi cisterna membrane [GO:0032580]; trans-Golgi network [GO:0005802]; vesicle membrane [GO:0012506]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; intracellular protein transport [GO:0006886]; metabolic process [GO:0008152]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of receptor-mediated endocytosis [GO:0048260]; Rab protein signal transduction [GO:0032482]; regulation of exocytosis [GO:0017157]	intracellular protein transport [GO:0006886]; metabolic process [GO:0008152]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of receptor-mediated endocytosis [GO:0048260]; Rab protein signal transduction [GO:0032482]; regulation of exocytosis [GO:0017157]	GDP binding [GO:0019003]; GTPase activity [GO:0003924]; GTP binding [GO:0005525]	cleavage furrow [GO:0032154]; cytoplasmic side of early endosome membrane [GO:0098559]; cytoplasmic side of plasma membrane [GO:0009898]; cytoplasmic vesicle membrane [GO:0030659]; early endosome [GO:0005769]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi cisterna membrane [GO:0032580]; trans-Golgi network [GO:0005802]; vesicle membrane [GO:0012506]	GO:0019003; GO:0005525; GO:0003924; GO:0032580; GO:0032482; GO:0032154; GO:0098559; GO:0009898; GO:0030659; GO:0005769; GO:0005789; GO:0005768; GO:0070062; GO:0005925; GO:0006886; GO:0008152; GO:2000643; GO:0048260; GO:0017157; GO:0005802; GO:0012506	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:19745841}. Golgi apparatus membrane. Early endosome membrane. Cytoplasmic vesicle membrane. Cleavage furrow. Note=Colocalizes with ANKRD27 and VAMP7 in neurites (By similarity). In nonpolarized epithelial Caco-2 cells, found in the endoplasmic reticulum; in polarized cells, observed in vesicles in the apical cytoplasm. During mitosis, in mid-telophase, localized in the ingressing cleavage furrow. In late telophase, detected at the opposite poles of the daughter cells, in vesicles at the base of lamellipodia formed by the separating daughter cells. {ECO:0000250|UniProtKB:P35282, ECO:0000250|UniProtKB:Q6AXT5}.	3D-structure; Acetylation; Complete proteome; Cytoplasmic vesicle; Direct protein sequencing; Endoplasmic reticulum; Endosome; GTP-binding; Golgi apparatus; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Prenylation; Protein transport; Reference proteome; Transport	Beta strand (7); Chain (1); Helix (9); Initiator methionine (1); Lipidation (2); Modified residue (2); Motif (1); Mutagenesis (2); Nucleotide binding (4); Propeptide (1); Turn (1)
AEBP2_HUMAN	Q6ZN18	AEBP2_HUMAN	reviewed	Zinc finger protein AEBP2 (Adipocyte enhancer-binding protein 2) (AE-binding protein 2)	AEBP2	Homo sapiens (Human)	517	ESC/E(Z) complex [GO:0035098]; nucleoplasm [GO:0005654]; metal ion binding [GO:0046872]; RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [GO:0001078]; transcription corepressor activity [GO:0003714]; chromatin modification [GO:0016568]; chromatin organization [GO:0006325]; gene expression [GO:0010467]; negative regulation of gene expression, epigenetic [GO:0045814]; regulation of gene expression, epigenetic [GO:0040029]	chromatin modification [GO:0016568]; chromatin organization [GO:0006325]; gene expression [GO:0010467]; negative regulation of gene expression, epigenetic [GO:0045814]; regulation of gene expression, epigenetic [GO:0040029]	metal ion binding [GO:0046872]; RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [GO:0001078]; transcription corepressor activity [GO:0003714]	ESC/E(Z) complex [GO:0035098]; nucleoplasm [GO:0005654]	GO:0035098; GO:0000978; GO:0001078; GO:0016568; GO:0006325; GO:0010467; GO:0046872; GO:0045814; GO:0005654; GO:0040029; GO:0003714	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.	Acetylation; Alternative splicing; Chromatin regulator; Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger	Alternative sequence (3); Chain (1); Compositional bias (3); Erroneous initiation (3); Erroneous termination (1); Initiator methionine (1); Modified residue (7); Region (2); Zinc finger (3)
TP4AP_HUMAN	Q8TEL6	TP4AP_HUMAN	reviewed	Short transient receptor potential channel 4-associated protein (Trp4-associated protein) (Trpc4-associated protein) (Protein TAP1) (TNF-receptor ubiquitous scaffolding/signaling protein) (Protein TRUSS)	TRPC4AP C20orf188 TRRP4AP	Homo sapiens (Human)	797	Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; plasma membrane [GO:0005886]; phosphatase binding [GO:0019902]; calcium ion transmembrane transport [GO:0070588]; ion transmembrane transport [GO:0034220]; protein ubiquitination [GO:0016567]; transmembrane transport [GO:0055085]; ubiquitin-dependent protein catabolic process [GO:0006511]	calcium ion transmembrane transport [GO:0070588]; ion transmembrane transport [GO:0034220]; protein ubiquitination [GO:0016567]; transmembrane transport [GO:0055085]; ubiquitin-dependent protein catabolic process [GO:0006511]	phosphatase binding [GO:0019902]	Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; plasma membrane [GO:0005886]	GO:0031464; GO:0070588; GO:0034220; GO:0019902; GO:0005886; GO:0016567; GO:0055085; GO:0006511		Acetylation; Alternative splicing; Complete proteome; Reference proteome; Ubl conjugation pathway	Alternative sequence (2); Chain (1); Frameshift (1); Initiator methionine (1); Modified residue (1); Region (1)
LYPL1_HUMAN	Q5VWZ2	LYPL1_HUMAN	reviewed	Lysophospholipase-like protein 1 (EC 3.1.2.-)	LYPLAL1	Homo sapiens (Human)	237	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lysophospholipase activity [GO:0004622]; negative regulation of Golgi to plasma membrane protein transport [GO:0042997]; protein depalmitoylation [GO:0002084]	negative regulation of Golgi to plasma membrane protein transport [GO:0042997]; protein depalmitoylation [GO:0002084]	lysophospholipase activity [GO:0004622]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0005737; GO:0005829; GO:0070062; GO:0004622; GO:0042997; GO:0002084	SUBCELLULAR LOCATION: Isoform 1: Cytoplasm, cytosol {ECO:0000269|PubMed:22399288}.; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm, cytosol {ECO:0000269|PubMed:22399288}.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Polymorphism; Reference proteome	Active site (3); Alternative sequence (1); Beta strand (11); Chain (1); Helix (8); Initiator methionine (1); Modified residue (1); Natural variant (2); Sequence conflict (1)
C9J9K3_HUMAN	C9J9K3	C9J9K3_HUMAN	unreviewed	40S ribosomal protein SA (Fragment)	RPSA	Homo sapiens (Human)	264	90S preribosome [GO:0030686]; small ribosomal subunit [GO:0015935]; structural constituent of ribosome [GO:0003735]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000461]; ribosomal small subunit assembly [GO:0000028]; rRNA export from nucleus [GO:0006407]; translation [GO:0006412]	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000461]; ribosomal small subunit assembly [GO:0000028]; rRNA export from nucleus [GO:0006407]; translation [GO:0006412]	structural constituent of ribosome [GO:0003735]	90S preribosome [GO:0030686]; small ribosomal subunit [GO:0015935]	GO:0030686; GO:0000447; GO:0000461; GO:0006407; GO:0000028; GO:0015935; GO:0003735; GO:0006412		Complete proteome; Cytoplasm; Proteomics identification; Reference proteome; Ribonucleoprotein; Ribosomal protein	Non-terminal residue (1)
I2BP2_HUMAN	Q7Z5L9	I2BP2_HUMAN	reviewed	Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2)	IRF2BP2	Homo sapiens (Human)	587	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]	regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]	metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005737; GO:0046872; GO:0005654; GO:0005634; GO:0006355; GO:0006351	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.	Acetylation; Activator; Alternative splicing; Complete proteome; Cytoplasm; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger	Alternative sequence (2); Chain (1); Compositional bias (1); Initiator methionine (1); Modified residue (9); Motif (1); Natural variant (1); Region (1); Sequence conflict (6); Zinc finger (1)
ALKB1_HUMAN	Q13686	ALKB1_HUMAN	reviewed	Alkylated DNA repair protein alkB homolog 1 (EC 1.14.11.33) (Alpha-ketoglutarate-dependent dioxygenase ABH1) (DNA lyase ABH1) (EC 4.2.99.18) (DNA oxidative demethylase ALKBH1)	ALKBH1 ABH ABH1 ALKBH	Homo sapiens (Human)	389	mitochondrion [GO:0005739]; nuclear euchromatin [GO:0005719]; chemoattractant activity [GO:0042056]; DNA-(apurinic or apyrimidinic site) lyase activity [GO:0003906]; ferrous iron binding [GO:0008198]; methylcytosine dioxygenase activity [GO:0070579]; developmental growth [GO:0048589]; DNA dealkylation involved in DNA repair [GO:0006307]; DNA demethylation [GO:0080111]; DNA repair [GO:0006281]; in utero embryonic development [GO:0001701]; negative regulation of neuron apoptotic process [GO:0043524]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; oxidative demethylation [GO:0070989]; placenta development [GO:0001890]; RNA repair [GO:0042245]	developmental growth [GO:0048589]; DNA dealkylation involved in DNA repair [GO:0006307]; DNA demethylation [GO:0080111]; DNA repair [GO:0006281]; in utero embryonic development [GO:0001701]; negative regulation of neuron apoptotic process [GO:0043524]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; oxidative demethylation [GO:0070989]; placenta development [GO:0001890]; RNA repair [GO:0042245]	chemoattractant activity [GO:0042056]; DNA-(apurinic or apyrimidinic site) lyase activity [GO:0003906]; ferrous iron binding [GO:0008198]; methylcytosine dioxygenase activity [GO:0070579]	mitochondrion [GO:0005739]; nuclear euchromatin [GO:0005719]	GO:0006307; GO:0080111; GO:0006281; GO:0003906; GO:0042245; GO:0042056; GO:0048589; GO:0008198; GO:0001701; GO:0070579; GO:0005739; GO:0043524; GO:0001764; GO:0031175; GO:0005719; GO:0070989; GO:0001890	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:17979886, ECO:0000269|PubMed:18603530}. Nucleus {ECO:0000250}. Note=Mainly localizes in euchromatin, largely excluded from heterochromatin and nucleoli. {ECO:0000250}.	Complete proteome; DNA damage; DNA repair; Dioxygenase; Iron; Lyase; Metal-binding; Mitochondrion; Multifunctional enzyme; Nucleus; Oxidoreductase; Polymorphism; RNA repair; Reference proteome	Binding site (2); Chain (1); Domain (1); Frameshift (1); Metal binding (3); Mutagenesis (6); Natural variant (2); Region (3); Sequence conflict (3)
CE051_HUMAN	A6NDU8	CE051_HUMAN	reviewed	UPF0600 protein C5orf51	C5orf51	Homo sapiens (Human)	294							Acetylation; Complete proteome; Polymorphism; Reference proteome	Chain (1); Initiator methionine (1); Modified residue (1); Natural variant (1); Sequence caution (1)
NUMA1_HUMAN	Q14980	NUMA1_HUMAN	reviewed	Nuclear mitotic apparatus protein 1 (NuMA protein) (Nuclear matrix protein-22) (NMP-22) (SP-H antigen)	NUMA1 NMP22 NUMA	Homo sapiens (Human)	2115	apical part of cell [GO:0045177]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; neuronal cell body [GO:0043025]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle microtubule [GO:0005876]; spindle pole [GO:0000922]; structural molecule activity [GO:0005198]; cell division [GO:0051301]; establishment of mitotic spindle orientation [GO:0000132]; G2/M transition of mitotic cell cycle [GO:0000086]; lung epithelial cell differentiation [GO:0060487]; meiotic cell cycle [GO:0051321]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; nucleus organization [GO:0006997]	cell division [GO:0051301]; establishment of mitotic spindle orientation [GO:0000132]; G2/M transition of mitotic cell cycle [GO:0000086]; lung epithelial cell differentiation [GO:0060487]; meiotic cell cycle [GO:0051321]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; nucleus organization [GO:0006997]	structural molecule activity [GO:0005198]	apical part of cell [GO:0045177]; chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; neuronal cell body [GO:0043025]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle microtubule [GO:0005876]; spindle pole [GO:0000922]	GO:0000086; GO:0000139; GO:0045177; GO:0051301; GO:0005694; GO:0005737; GO:0005829; GO:0030425; GO:0000132; GO:0070062; GO:0060487; GO:0051321; GO:0000278; GO:0007067; GO:0043025; GO:0016363; GO:0005654; GO:0005634; GO:0006997; GO:0005819; GO:0005876; GO:0000922; GO:0005198	SUBCELLULAR LOCATION: Nucleus matrix. Chromosome. Cytoplasm, cytoskeleton, spindle pole. Note=Resides in the nuclear matrix during interphases. Dissociates from condensing chromosomes during early prophase, and relocates to the spindle poles via dynein/dynamin association, it remain there until the anaphase onset. Before the complete disintegration of the nuclear lamina. As mitosis progresses it reassociates with telophase chromosomes very early during nuclear reformation, before substantial accumulation of lamins on chromosomal surfaces is evident.; SUBCELLULAR LOCATION: Isoform Numa-m: Cytoplasm. Note=Mainly clustered at the centrosomal region.; SUBCELLULAR LOCATION: Isoform Numa-s: Cytoplasm. Note=Mainly clustered at the centrosomal region.	3D-structure; ADP-ribosylation; Acetylation; Alternative splicing; Cell cycle; Cell division; Chromosome; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Glycoprotein; Microtubule; Mitosis; Nucleus; Phosphoprotein; Polymorphism; Reference proteome	Alternative sequence (4); Chain (1); Coiled coil (1); Frameshift (1); Glycosylation (1); Helix (1); Modified residue (45); Motif (1); Mutagenesis (6); Natural variant (6); Region (3); Sequence conflict (9); Turn (1)
DENR_HUMAN	O43583	DENR_HUMAN	reviewed	Density-regulated protein (DRP) (Protein DRP1) (Smooth muscle cell-associated protein 3) (SMAP-3)	DENR DRP1 H14	Homo sapiens (Human)	198	translation initiation factor activity [GO:0003743]; formation of translation preinitiation complex [GO:0001731]; IRES-dependent translational initiation [GO:0002192]; ribosome disassembly [GO:0032790]	formation of translation preinitiation complex [GO:0001731]; IRES-dependent translational initiation [GO:0002192]; ribosome disassembly [GO:0032790]	translation initiation factor activity [GO:0003743]		GO:0002192; GO:0001731; GO:0032790; GO:0003743		Acetylation; Complete proteome; Initiation factor; Phosphoprotein; Protein biosynthesis; Reference proteome	Chain (1); Domain (1); Erroneous initiation (1); Initiator methionine (1); Modified residue (2); Sequence conflict (1)
GCN1L_HUMAN	Q92616	GCN1L_HUMAN	reviewed	Translational activator GCN1 (HsGCN1) (GCN1-like protein 1)	GCN1L1 KIAA0219	Homo sapiens (Human)	2671	cytoplasm [GO:0005737]; membrane [GO:0016020]; ribosome [GO:0005840]; poly(A) RNA binding [GO:0044822]; translation factor activity, RNA binding [GO:0008135]; regulation of translation [GO:0006417]; translation [GO:0006412]	regulation of translation [GO:0006417]; translation [GO:0006412]	poly(A) RNA binding [GO:0044822]; translation factor activity, RNA binding [GO:0008135]	cytoplasm [GO:0005737]; membrane [GO:0016020]; ribosome [GO:0005840]	GO:0005737; GO:0016020; GO:0044822; GO:0006417; GO:0005840; GO:0006412; GO:0008135		Acetylation; Complete proteome; Direct protein sequencing; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Translation regulation	Chain (1); Erroneous gene model prediction (1); Erroneous initiation (1); Frameshift (1); Initiator methionine (1); Modified residue (2); Natural variant (1); Repeat (24); Sequence conflict (9)
TF3C5_HUMAN	Q9Y5Q8	TF3C5_HUMAN	reviewed	General transcription factor 3C polypeptide 5 (TF3C-epsilon) (Transcription factor IIIC 63 kDa subunit) (TFIIIC 63 kDa subunit) (TFIIIC63) (Transcription factor IIIC subunit epsilon)	GTF3C5 CDABP0017	Homo sapiens (Human)	519	nucleoplasm [GO:0005654]; transcription factor TFIIIC complex [GO:0000127]; DNA binding [GO:0003677]; 5S class rRNA transcription from RNA polymerase III type 1 promoter [GO:0042791]; gene expression [GO:0010467]; skeletal muscle cell differentiation [GO:0035914]; transcription from RNA polymerase III promoter [GO:0006383]; transcription, DNA-templated [GO:0006351]; tRNA transcription from RNA polymerase III promoter [GO:0042797]	5S class rRNA transcription from RNA polymerase III type 1 promoter [GO:0042791]; gene expression [GO:0010467]; skeletal muscle cell differentiation [GO:0035914]; transcription, DNA-templated [GO:0006351]; transcription from RNA polymerase III promoter [GO:0006383]; tRNA transcription from RNA polymerase III promoter [GO:0042797]	DNA binding [GO:0003677]	nucleoplasm [GO:0005654]; transcription factor TFIIIC complex [GO:0000127]	GO:0042791; GO:0003677; GO:0010467; GO:0005654; GO:0035914; GO:0042797; GO:0000127; GO:0006383; GO:0006351	SUBCELLULAR LOCATION: Nucleus.	Acetylation; Alternative splicing; Complete proteome; DNA-binding; Nucleus; Polymorphism; Reference proteome; Transcription	Alternative sequence (2); Chain (1); Compositional bias (2); Initiator methionine (1); Modified residue (1); Natural variant (1); Sequence conflict (2)
DHX9_HUMAN	Q08211	DHX9_HUMAN	reviewed	ATP-dependent RNA helicase A (RHA) (EC 3.6.4.13) (DEAH box protein 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II)	DHX9 DDX9 LKP NDH2	Homo sapiens (Human)	1270	centrosome [GO:0005813]; CRD-mediated mRNA stability complex [GO:0070937]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]; ATP binding [GO:0005524]; ATP-dependent DNA helicase activity [GO:0004003]; ATP-dependent RNA helicase activity [GO:0004004]; DNA binding [GO:0003677]; poly(A) RNA binding [GO:0044822]; RNA helicase activity [GO:0003724]; RNA polymerase II transcription factor binding [GO:0001085]; cellular response to heat [GO:0034605]; circadian rhythm [GO:0007623]; CRD-mediated mRNA stabilization [GO:0070934]; DNA duplex unwinding [GO:0032508]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mRNA splicing, via spliceosome [GO:0000398]; osteoblast differentiation [GO:0001649]; positive regulation of type I interferon production [GO:0032481]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]	cellular response to heat [GO:0034605]; circadian rhythm [GO:0007623]; CRD-mediated mRNA stabilization [GO:0070934]; DNA duplex unwinding [GO:0032508]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mRNA splicing, via spliceosome [GO:0000398]; osteoblast differentiation [GO:0001649]; positive regulation of type I interferon production [GO:0032481]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]	ATP binding [GO:0005524]; ATP-dependent DNA helicase activity [GO:0004003]; ATP-dependent RNA helicase activity [GO:0004004]; DNA binding [GO:0003677]; poly(A) RNA binding [GO:0044822]; RNA helicase activity [GO:0003724]; RNA polymerase II transcription factor binding [GO:0001085]	centrosome [GO:0005813]; CRD-mediated mRNA stability complex [GO:0070937]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]	GO:0005524; GO:0004003; GO:0004004; GO:0070937; GO:0070934; GO:0003677; GO:0032508; GO:0003724; GO:0001085; GO:0006396; GO:0008380; GO:0034605; GO:0005813; GO:0007623; GO:0005737; GO:0036464; GO:0005829; GO:0010467; GO:0045087; GO:0000398; GO:0016020; GO:0005730; GO:0005654; GO:0005634; GO:0001649; GO:0044822; GO:0032481; GO:0030529	SUBCELLULAR LOCATION: Nucleus, nucleolus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Can shuttle between nucleus and cytoplasm.	3D-structure; ATP-binding; Acetylation; Activator; Alternative splicing; Biological rhythms; Complete proteome; Cytoplasm; DNA-binding; Direct protein sequencing; Helicase; Hydrolase; Methylation; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; RNA-binding; Reference proteome; Repeat	Alternative sequence (1); Beta strand (13); Chain (1); Domain (4); Helix (18); Modified residue (6); Motif (2); Mutagenesis (7); Natural variant (1); Nucleotide binding (1); Region (4); Sequence conflict (22); Turn (4)
IGBP1_HUMAN	P78318	IGBP1_HUMAN	reviewed	Immunoglobulin-binding protein 1 (B-cell signal transduction molecule alpha 4) (Protein alpha-4) (CD79a-binding protein 1) (Protein phosphatase 2/4/6 regulatory subunit) (Renal carcinoma antigen NY-REN-16)	IGBP1 IBP1	Homo sapiens (Human)	339	cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule [GO:0005874]; protein phosphatase 2A binding [GO:0051721]; protein phosphatase type 2A regulator activity [GO:0008601]; B cell activation [GO:0042113]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of protein dephosphorylation [GO:0035308]; negative regulation of stress-activated MAPK cascade [GO:0032873]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of dephosphorylation [GO:0035306]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of microtubule-based movement [GO:0060632]; regulation of protein phosphatase type 2A activity [GO:0034047]; response to interleukin-1 [GO:0070555]; response to tumor necrosis factor [GO:0034612]; signal transduction [GO:0007165]	B cell activation [GO:0042113]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of protein dephosphorylation [GO:0035308]; negative regulation of stress-activated MAPK cascade [GO:0032873]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of dephosphorylation [GO:0035306]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of microtubule-based movement [GO:0060632]; regulation of protein phosphatase type 2A activity [GO:0034047]; response to interleukin-1 [GO:0070555]; response to tumor necrosis factor [GO:0034612]; signal transduction [GO:0007165]	protein phosphatase 2A binding [GO:0051721]; protein phosphatase type 2A regulator activity [GO:0008601]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule [GO:0005874]	GO:0042113; GO:0005737; GO:0005829; GO:0005874; GO:2001234; GO:0043154; GO:0035308; GO:0032873; GO:0000122; GO:0035306; GO:0045944; GO:0051721; GO:0008601; GO:0060632; GO:0034047; GO:0070555; GO:0034612; GO:0007165	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.	3D-structure; Acetylation; B-cell activation; Chaperone; Complete proteome; Cytoplasm; Mental retardation; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation	Beta strand (1); Chain (1); Domain (1); Helix (10); Initiator methionine (1); Modified residue (2); Mutagenesis (4); Natural variant (1); Region (2); Site (1); Turn (1)
PA1B2_HUMAN	P68402	PA1B2_HUMAN	reviewed	Platelet-activating factor acetylhydrolase IB subunit beta (EC 3.1.1.47) (PAF acetylhydrolase 30 kDa subunit) (PAF-AH 30 kDa subunit) (PAF-AH subunit beta) (PAFAH subunit beta)	PAFAH1B2 PAFAHB	Homo sapiens (Human)	229	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; 1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; platelet-activating factor acetyltransferase activity [GO:0047179]; brain development [GO:0007420]; lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629]; positive regulation of macroautophagy [GO:0016239]; spermatogenesis [GO:0007283]	brain development [GO:0007420]; lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629]; positive regulation of macroautophagy [GO:0016239]; spermatogenesis [GO:0007283]	1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; platelet-activating factor acetyltransferase activity [GO:0047179]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]	GO:0003847; GO:0007420; GO:0005737; GO:0005829; GO:0070062; GO:0016042; GO:0006629; GO:0005730; GO:0005886; GO:0047179; GO:0016239; GO:0007283	SUBCELLULAR LOCATION: Cytoplasm.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Lipid degradation; Lipid metabolism; Phosphoprotein; Reference proteome	Active site (3); Alternative sequence (3); Beta strand (9); Chain (1); Helix (9); Initiator methionine (1); Modified residue (2); Sequence conflict (2); Turn (2)
CLCA_HUMAN	P09496	CLCA_HUMAN	reviewed	Clathrin light chain A (Lca)	CLTA	Homo sapiens (Human)	248	clathrin coat [GO:0030118]; clathrin coat of coated pit [GO:0030132]; clathrin coat of trans-Golgi network vesicle [GO:0030130]; clathrin complex [GO:0071439]; clathrin vesicle coat [GO:0030125]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytoplasmic membrane-bounded vesicle [GO:0016023]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; clathrin heavy chain binding [GO:0032050]; peptide binding [GO:0042277]; structural molecule activity [GO:0005198]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; axon guidance [GO:0007411]; clathrin-mediated endocytosis [GO:0072583]; epidermal growth factor receptor signaling pathway [GO:0007173]; intracellular protein transport [GO:0006886]; membrane organization [GO:0061024]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; neurotrophin TRK receptor signaling pathway [GO:0048011]; post-Golgi vesicle-mediated transport [GO:0006892]	antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; axon guidance [GO:0007411]; clathrin-mediated endocytosis [GO:0072583]; epidermal growth factor receptor signaling pathway [GO:0007173]; intracellular protein transport [GO:0006886]; membrane organization [GO:0061024]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; neurotrophin TRK receptor signaling pathway [GO:0048011]; post-Golgi vesicle-mediated transport [GO:0006892]	clathrin heavy chain binding [GO:0032050]; peptide binding [GO:0042277]; structural molecule activity [GO:0005198]	clathrin coat [GO:0030118]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin coat of coated pit [GO:0030132]; clathrin coat of trans-Golgi network vesicle [GO:0030130]; clathrin complex [GO:0071439]; clathrin vesicle coat [GO:0030125]; cytoplasmic membrane-bounded vesicle [GO:0016023]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]	GO:0019886; GO:0007411; GO:0030118; GO:0030132; GO:0030130; GO:0071439; GO:0032050; GO:0030125; GO:0030669; GO:0072583; GO:0016023; GO:0005829; GO:0007173; GO:0043231; GO:0006886; GO:0016020; GO:0061024; GO:0042059; GO:0048011; GO:0042277; GO:0005886; GO:0006892; GO:0005198; GO:0032588	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic face of coated pits and vesicles.	Acetylation; Alternative splicing; Calcium; Coated pit; Complete proteome; Cytoplasmic vesicle; Membrane; Phosphoprotein; Reference proteome	Alternative sequence (4); Chain (1); Modified residue (4); Region (1); Sequence conflict (1)
FUBP1_HUMAN	Q96AE4	FUBP1_HUMAN	reviewed	Far upstream element-binding protein 1 (FBP) (FUSE-binding protein 1) (DNA helicase V) (hDH V)	FUBP1	Homo sapiens (Human)	644	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; poly(A) RNA binding [GO:0044822]; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [GO:0001205]; sequence-specific DNA binding transcription factor activity [GO:0003700]; single-stranded DNA binding [GO:0003697]; positive regulation of gene expression [GO:0010628]; transcription from RNA polymerase II promoter [GO:0006366]	positive regulation of gene expression [GO:0010628]; transcription from RNA polymerase II promoter [GO:0006366]	poly(A) RNA binding [GO:0044822]; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [GO:0001205]; sequence-specific DNA binding transcription factor activity [GO:0003700]; single-stranded DNA binding [GO:0003697]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0001205; GO:0005654; GO:0005634; GO:0044822; GO:0010628; GO:0003700; GO:0003697; GO:0006366	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.	3D-structure; Acetylation; Alternative splicing; Complete proteome; DNA-binding; Direct protein sequencing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Ubl conjugation	Alternative sequence (2); Beta strand (9); Chain (1); Compositional bias (3); Domain (4); Helix (14); Initiator methionine (1); Modified residue (4); Natural variant (1); Turn (2)
E9PEB5_HUMAN	E9PEB5	E9PEB5_HUMAN	unreviewed	Far upstream element-binding protein 1	FUBP1	Homo sapiens (Human)	655	nucleoplasm [GO:0005654]; RNA binding [GO:0003723]		RNA binding [GO:0003723]	nucleoplasm [GO:0005654]	GO:0003723; GO:0005654		Complete proteome; Proteomics identification; Reference proteome	
ELOA1_HUMAN	Q14241	ELOA1_HUMAN	reviewed	Transcription elongation factor B polypeptide 3 (Elongin 110 kDa subunit) (Elongin-A) (EloA) (RNA polymerase II transcription factor SIII subunit A1) (SIII p110)	TCEB3 MSTP059	Homo sapiens (Human)	798	cytoplasm [GO:0005737]; elongin complex [GO:0070449]; extracellular space [GO:0005615]; integral component of membrane [GO:0016021]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; gene expression [GO:0010467]; positive regulation of viral transcription [GO:0050434]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]; viral process [GO:0016032]	gene expression [GO:0010467]; positive regulation of viral transcription [GO:0050434]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]; viral process [GO:0016032]	DNA binding [GO:0003677]	cytoplasm [GO:0005737]; elongin complex [GO:0070449]; extracellular space [GO:0005615]; integral component of membrane [GO:0016021]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003677; GO:0005737; GO:0070449; GO:0005615; GO:0010467; GO:0016021; GO:0005654; GO:0005634; GO:0050434; GO:0042787; GO:0006357; GO:0006368; GO:0006366; GO:0016032	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.	3D-structure; Acetylation; Complete proteome; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation	Beta strand (1); Chain (1); Domain (2); Erroneous initiation (6); Helix (5); Modified residue (4); Natural variant (3); Region (2)
MED12_HUMAN	Q93074	MED12_HUMAN	reviewed	Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein)	MED12 ARC240 CAGH45 HOPA KIAA0192 TNRC11 TRAP230	Homo sapiens (Human)	2177	centrosome [GO:0005813]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; ligand-dependent nuclear receptor transcription coactivator activity [GO:0030374]; protein C-terminus binding [GO:0008022]; protein domain specific binding [GO:0019904]; receptor activity [GO:0004872]; RNA polymerase II distal enhancer sequence-specific DNA binding [GO:0000980]; RNA polymerase II transcription cofactor activity [GO:0001104]; RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [GO:0001190]; thyroid hormone receptor binding [GO:0046966]; transcription coactivator activity [GO:0003713]; transcription cofactor activity [GO:0003712]; vitamin D receptor binding [GO:0042809]; androgen receptor signaling pathway [GO:0030521]; axis elongation involved in somitogenesis [GO:0090245]; canonical Wnt signaling pathway [GO:0060070]; gene expression [GO:0010467]; heart development [GO:0007507]; intracellular steroid hormone receptor signaling pathway [GO:0030518]; negative regulation of Wnt signaling pathway [GO:0030178]; neural tube closure [GO:0001843]; oligodendrocyte development [GO:0014003]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]; Schwann cell development [GO:0014044]; stem cell maintenance [GO:0019827]; transcription initiation from RNA polymerase II promoter [GO:0006367]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	androgen receptor signaling pathway [GO:0030521]; axis elongation involved in somitogenesis [GO:0090245]; canonical Wnt signaling pathway [GO:0060070]; gene expression [GO:0010467]; heart development [GO:0007507]; intracellular steroid hormone receptor signaling pathway [GO:0030518]; negative regulation of Wnt signaling pathway [GO:0030178]; neural tube closure [GO:0001843]; oligodendrocyte development [GO:0014003]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; Schwann cell development [GO:0014044]; stem cell maintenance [GO:0019827]; transcription initiation from RNA polymerase II promoter [GO:0006367]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]	chromatin binding [GO:0003682]; ligand-dependent nuclear receptor transcription coactivator activity [GO:0030374]; protein C-terminus binding [GO:0008022]; protein domain specific binding [GO:0019904]; receptor activity [GO:0004872]; RNA polymerase II distal enhancer sequence-specific DNA binding [GO:0000980]; RNA polymerase II transcription cofactor activity [GO:0001104]; RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [GO:0001190]; thyroid hormone receptor binding [GO:0046966]; transcription coactivator activity [GO:0003713]; transcription cofactor activity [GO:0003712]; vitamin D receptor binding [GO:0042809]	centrosome [GO:0005813]; mediator complex [GO:0016592]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000980; GO:0001104; GO:0001190; GO:0014044; GO:0060071; GO:0030521; GO:0090245; GO:0060070; GO:0005813; GO:0003682; GO:0010467; GO:0007507; GO:0030518; GO:0030374; GO:0016592; GO:0016020; GO:0030178; GO:0001843; GO:0005730; GO:0005654; GO:0005634; GO:0014003; GO:0045944; GO:0045893; GO:0008022; GO:0019904; GO:0004872; GO:0019827; GO:0046966; GO:0003713; GO:0003712; GO:0006367; GO:0042809	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.	Acetylation; Activator; Alternative splicing; Complete proteome; Direct protein sequencing; Disease mutation; Mental retardation; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation	Alternative sequence (2); Chain (1); Compositional bias (2); Erroneous initiation (1); Modified residue (8); Natural variant (6); Region (1); Sequence conflict (3)
GLRX3_HUMAN	O76003	GLRX3_HUMAN	reviewed	Glutaredoxin-3 (PKC-interacting cousin of thioredoxin) (PICOT) (PKC-theta-interacting protein) (PKCq-interacting protein) (Thioredoxin-like protein 2)	GLRX3 PICOT TXNL2 HUSSY-22	Homo sapiens (Human)	335	cell cortex [GO:0005938]; extracellular exosome [GO:0070062]; Z disc [GO:0030018]; electron carrier activity [GO:0009055]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; poly(A) RNA binding [GO:0044822]; protein disulfide oxidoreductase activity [GO:0015035]; cell redox homeostasis [GO:0045454]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; regulation of the force of heart contraction [GO:0002026]	cell redox homeostasis [GO:0045454]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; regulation of the force of heart contraction [GO:0002026]	electron carrier activity [GO:0009055]; iron-sulfur cluster binding [GO:0051536]; metal ion binding [GO:0046872]; poly(A) RNA binding [GO:0044822]; protein disulfide oxidoreductase activity [GO:0015035]	cell cortex [GO:0005938]; extracellular exosome [GO:0070062]; Z disc [GO:0030018]	GO:0030018; GO:0005938; GO:0045454; GO:0009055; GO:0070062; GO:0051536; GO:0046872; GO:0010614; GO:0044822; GO:0015035; GO:0002026	SUBCELLULAR LOCATION: Cytoplasm, cell cortex {ECO:0000269|PubMed:10636891}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Under the plasma membrane. After PMA stimulation, GLRX3 and PRKCQ/PKC-theta translocate to a more extended submembrane area. In the Z line, found associated with CSRP3 (By similarity). {ECO:0000250}.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Iron; Iron-sulfur; Metal-binding; Polymorphism; Reference proteome; Repeat	Beta strand (15); Chain (1); Domain (3); Helix (16); Initiator methionine (1); Metal binding (2); Modified residue (1); Mutagenesis (2); Natural variant (2); Sequence conflict (3); Turn (2)
RPA43_HUMAN	Q3B726	RPA43_HUMAN	reviewed	DNA-directed RNA polymerase I subunit RPA43 (Twist neighbor protein)	TWISTNB	Homo sapiens (Human)	338	DNA-directed RNA polymerase I complex [GO:0005736]; microtubule cytoskeleton [GO:0015630]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-directed RNA polymerase activity [GO:0003899]; gene expression [GO:0010467]; negative regulation of gene expression, epigenetic [GO:0045814]; regulation of gene expression, epigenetic [GO:0040029]; termination of RNA polymerase I transcription [GO:0006363]; transcription elongation from RNA polymerase I promoter [GO:0006362]; transcription from RNA polymerase I promoter [GO:0006360]; transcription initiation from RNA polymerase I promoter [GO:0006361]	gene expression [GO:0010467]; negative regulation of gene expression, epigenetic [GO:0045814]; regulation of gene expression, epigenetic [GO:0040029]; termination of RNA polymerase I transcription [GO:0006363]; transcription elongation from RNA polymerase I promoter [GO:0006362]; transcription from RNA polymerase I promoter [GO:0006360]; transcription initiation from RNA polymerase I promoter [GO:0006361]	DNA-directed RNA polymerase activity [GO:0003899]	DNA-directed RNA polymerase I complex [GO:0005736]; microtubule cytoskeleton [GO:0015630]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005736; GO:0003899; GO:0010467; GO:0015630; GO:0045814; GO:0005730; GO:0005654; GO:0005634; GO:0040029; GO:0006363; GO:0006362; GO:0006360; GO:0006361	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.	Complete proteome; DNA-directed RNA polymerase; Nucleus; Phosphoprotein; Reference proteome; Transcription	Chain (1); Compositional bias (1); Frameshift (1); Modified residue (2)
H0YGR4_HUMAN	H0YGR4	H0YGR4_HUMAN	unreviewed	Oligoribonuclease, mitochondrial (Fragment)	REXO2	Homo sapiens (Human)	192	3'-5'-exoribonuclease activity [GO:0000175]; nucleic acid binding [GO:0003676]; RNA phosphodiester bond hydrolysis, exonucleolytic [GO:0090503]	RNA phosphodiester bond hydrolysis, exonucleolytic [GO:0090503]	3'-5'-exoribonuclease activity [GO:0000175]; nucleic acid binding [GO:0003676]		GO:0000175; GO:0090503; GO:0003676		Complete proteome; Proteomics identification; Reference proteome	Non-terminal residue (1)
EXOS8_HUMAN	Q96B26	EXOS8_HUMAN	reviewed	Exosome complex component RRP43 (Exosome component 8) (Opa-interacting protein 2) (OIP-2) (Ribosomal RNA-processing protein 43) (p9)	EXOSC8 OIP2 RRP43	Homo sapiens (Human)	276	cytoplasm [GO:0005737]; cytosol [GO:0005829]; exosome (RNase complex) [GO:0000178]; nucleolus [GO:0005730]; nucleus [GO:0005634]; AU-rich element binding [GO:0017091]; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [GO:0043928]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; rRNA processing [GO:0006364]	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [GO:0043928]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; rRNA processing [GO:0006364]	AU-rich element binding [GO:0017091]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; exosome (RNase complex) [GO:0000178]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0017091; GO:0005737; GO:0005829; GO:0043928; GO:0000178; GO:0010467; GO:0000288; GO:0005730; GO:0005634; GO:0006364	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17545563}. Nucleus {ECO:0000269|PubMed:17545563}. Nucleus, nucleolus {ECO:0000250}.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Disease mutation; Exosome; Neurodegeneration; Nucleus; RNA-binding; Reference proteome; rRNA processing	Beta strand (14); Chain (1); Erroneous gene model prediction (2); Helix (5); Initiator methionine (1); Modified residue (1); Natural variant (2); Sequence conflict (1); Turn (3)
F8WEY7_HUMAN	F8WEY7	F8WEY7_HUMAN	unreviewed	Muskelin	MKLN1	Homo sapiens (Human)	170							Complete proteome; Proteomics identification; Reference proteome	
PUR8_HUMAN	P30566	PUR8_HUMAN	reviewed	Adenylosuccinate lyase (ASL) (EC 4.3.2.2) (Adenylosuccinase) (ASase)	ADSL AMPS	Homo sapiens (Human)	484	cytosol [GO:0005829]; mitochondrion [GO:0005739]; (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity [GO:0070626]; N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity [GO:0004018]; 'de novo' AMP biosynthetic process [GO:0044208]; 'de novo' IMP biosynthetic process [GO:0006189]; aerobic respiration [GO:0009060]; AMP biosynthetic process [GO:0006167]; metabolic process [GO:0008152]; nucleobase-containing small molecule metabolic process [GO:0055086]; protein tetramerization [GO:0051262]; purine nucleobase metabolic process [GO:0006144]; purine nucleotide biosynthetic process [GO:0006164]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168]; response to hypoxia [GO:0001666]; response to muscle activity [GO:0014850]; response to nutrient [GO:0007584]; response to starvation [GO:0042594]; small molecule metabolic process [GO:0044281]	'de novo' AMP biosynthetic process [GO:0044208]; 'de novo' IMP biosynthetic process [GO:0006189]; aerobic respiration [GO:0009060]; AMP biosynthetic process [GO:0006167]; metabolic process [GO:0008152]; nucleobase-containing small molecule metabolic process [GO:0055086]; protein tetramerization [GO:0051262]; purine nucleobase metabolic process [GO:0006144]; purine nucleotide biosynthetic process [GO:0006164]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168]; response to hypoxia [GO:0001666]; response to muscle activity [GO:0014850]; response to nutrient [GO:0007584]; response to starvation [GO:0042594]; small molecule metabolic process [GO:0044281]	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity [GO:0070626]; N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity [GO:0004018]	cytosol [GO:0005829]; mitochondrion [GO:0005739]	GO:0044208; GO:0006189; GO:0070626; GO:0006167; GO:0004018; GO:0009060; GO:0005829; GO:0008152; GO:0005739; GO:0055086; GO:0051262; GO:0006144; GO:0006164; GO:0009168; GO:0001666; GO:0014850; GO:0007584; GO:0042594; GO:0044281		3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Disease mutation; Epilepsy; Lyase; Purine biosynthesis; Reference proteome	Active site (2); Alternative sequence (1); Beta strand (6); Binding site (5); Chain (1); Erroneous initiation (2); Helix (27); Initiator methionine (1); Modified residue (3); Natural variant (29); Region (3); Turn (5)
H15_HUMAN	P16401	H15_HUMAN	reviewed	Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3)	HIST1H1B H1F5	Homo sapiens (Human)	226	extracellular exosome [GO:0070062]; nuclear chromatin [GO:0000790]; nuclear heterochromatin [GO:0005720]; nucleosome [GO:0000786]; chromatin DNA binding [GO:0031490]; histone deacetylase binding [GO:0042826]; poly(A) RNA binding [GO:0044822]; chromatin organization [GO:0006325]; establishment of protein localization to chromatin [GO:0071169]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; nucleosome assembly [GO:0006334]; positive regulation of cell growth [GO:0030307]; positive regulation of histone H3-K9 methylation [GO:0051574]; protein stabilization [GO:0050821]	chromatin organization [GO:0006325]; establishment of protein localization to chromatin [GO:0071169]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; nucleosome assembly [GO:0006334]; positive regulation of cell growth [GO:0030307]; positive regulation of histone H3-K9 methylation [GO:0051574]; protein stabilization [GO:0050821]	chromatin DNA binding [GO:0031490]; histone deacetylase binding [GO:0042826]; poly(A) RNA binding [GO:0044822]	extracellular exosome [GO:0070062]; nuclear chromatin [GO:0000790]; nuclear heterochromatin [GO:0005720]; nucleosome [GO:0000786]	GO:0031490; GO:0006325; GO:0071169; GO:0070062; GO:0042826; GO:0000122; GO:0000790; GO:0005720; GO:0000786; GO:0006334; GO:0044822; GO:0030307; GO:0051574; GO:0050821	SUBCELLULAR LOCATION: Nucleus. Chromosome. Note=According to PubMed:15911621 more commonly found in heterochromatin. According to PubMed:10997781 associates with actively transcribed chromatin and not heterochromatin.	3D-structure; Acetylation; Chromosome; Citrullination; Complete proteome; DNA-binding; Direct protein sequencing; Methylation; Nucleus; Phosphoprotein; Polymorphism; Reference proteome	Chain (1); Domain (1); Initiator methionine (1); Modified residue (23); Natural variant (3); Sequence conflict (1)
SF3B4_HUMAN	Q15427	SF3B4_HUMAN	reviewed	Splicing factor 3B subunit 4 (Pre-mRNA-splicing factor SF3b 49 kDa subunit) (SF3b50) (Spliceosome-associated protein 49) (SAP 49)	SF3B4 SAP49	Homo sapiens (Human)	424	nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]; nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; gene expression [GO:0010467]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]	gene expression [GO:0010467]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]	nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]	nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]	GO:0008380; GO:0000375; GO:0005689; GO:0010467; GO:0006397; GO:0000398; GO:0005654; GO:0000166; GO:0044822; GO:0048026; GO:0005681	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.	3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein; RNA-binding; Reference proteome; Repeat; Spliceosome; mRNA processing; mRNA splicing	Beta strand (10); Chain (1); Compositional bias (2); Domain (2); Helix (4); Initiator methionine (1); Modified residue (2); Turn (4)
NPM3_HUMAN	O75607	NPM3_HUMAN	reviewed	Nucleoplasmin-3	NPM3	Homo sapiens (Human)	178	nucleolus [GO:0005730]; poly(A) RNA binding [GO:0044822]; rRNA processing [GO:0006364]; rRNA transcription [GO:0009303]	rRNA processing [GO:0006364]; rRNA transcription [GO:0009303]	poly(A) RNA binding [GO:0044822]	nucleolus [GO:0005730]	GO:0005730; GO:0044822; GO:0006364; GO:0009303	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11722795}.	Acetylation; Chaperone; Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome	Chain (1); Compositional bias (3); Initiator methionine (1); Modified residue (6); Natural variant (2); Sequence conflict (2)
EF1G_HUMAN	P26641	EF1G_HUMAN	reviewed	Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma)	EEF1G EF1G PRO1608	Homo sapiens (Human)	437	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; translation elongation factor activity [GO:0003746]; cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; response to virus [GO:0009615]; translation [GO:0006412]; translational elongation [GO:0006414]	cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; response to virus [GO:0009615]; translation [GO:0006412]; translational elongation [GO:0006414]	translation elongation factor activity [GO:0003746]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]	GO:0044267; GO:0005737; GO:0005829; GO:0070062; GO:0010467; GO:0016020; GO:0005634; GO:0009615; GO:0006412; GO:0003746; GO:0006414		3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Elongation factor; Protein biosynthesis; Reference proteome	Alternative sequence (1); Beta strand (4); Chain (1); Domain (3); Helix (12); Initiator methionine (1); Modified residue (6); Sequence conflict (1); Turn (2)
RNH2B_HUMAN	Q5TBB1	RNH2B_HUMAN	reviewed	Ribonuclease H2 subunit B (RNase H2 subunit B) (Aicardi-Goutieres syndrome 2 protein) (AGS2) (Deleted in lymphocytic leukemia 8) (Ribonuclease HI subunit B)	RNASEH2B DLEU8	Homo sapiens (Human)	312	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonuclease H2 complex [GO:0032299]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; in utero embryonic development [GO:0001701]; negative regulation of gene expression [GO:0010629]; positive regulation of fibroblast proliferation [GO:0048146]; regulation of DNA damage checkpoint [GO:2000001]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; ribonucleotide metabolic process [GO:0009259]; RNA catabolic process [GO:0006401]	in utero embryonic development [GO:0001701]; negative regulation of gene expression [GO:0010629]; positive regulation of fibroblast proliferation [GO:0048146]; regulation of DNA damage checkpoint [GO:2000001]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; ribonucleotide metabolic process [GO:0009259]; RNA catabolic process [GO:0006401]	RNA-DNA hybrid ribonuclease activity [GO:0004523]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonuclease H2 complex [GO:0032299]	GO:0006401; GO:0004523; GO:0001701; GO:0010629; GO:0005654; GO:0005634; GO:0048146; GO:2000001; GO:0010389; GO:0032299; GO:0009259	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.	3D-structure; Acetylation; Aicardi-Goutieres syndrome; Alternative splicing; Complete proteome; Disease mutation; Nucleus; Reference proteome	Alternative sequence (2); Beta strand (9); Chain (1); Helix (8); Initiator methionine (1); Modified residue (2); Natural variant (14); Sequence caution (3); Sequence conflict (3); Turn (4)
AAGAB_HUMAN	Q6PD74	AAGAB_HUMAN	reviewed	Alpha- and gamma-adaptin-binding protein p34	AAGAB	Homo sapiens (Human)	315	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; protein transport [GO:0015031]	protein transport [GO:0015031]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	GO:0005737; GO:0005829; GO:0005654; GO:0015031	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:23000146, ECO:0000269|PubMed:23064416}.	Alternative splicing; Complete proteome; Cytoplasm; Palmoplantar keratoderma; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport	Alternative sequence (1); Chain (1); Modified residue (2); Natural variant (1); Sequence conflict (11)
H7C3G9_HUMAN	H7C3G9	H7C3G9_HUMAN	unreviewed	N-acetyl-D-glucosamine kinase	NAGK	Homo sapiens (Human)	340							Complete proteome; Proteomics identification; Reference proteome	
VTA1_HUMAN	Q9NP79	VTA1_HUMAN	reviewed	Vacuolar protein sorting-associated protein VTA1 homolog (Dopamine-responsive gene 1 protein) (DRG-1) (LYST-interacting protein 5) (LIP5) (SKD1-binding protein 1) (SBP1)	VTA1 C6orf55 HSPC228 My012	Homo sapiens (Human)	307	cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; protein C-terminus binding [GO:0008022]; endosomal transport [GO:0016197]; membrane organization [GO:0061024]; multivesicular body sorting pathway [GO:0071985]; protein transport [GO:0015031]; viral budding [GO:0046755]; viral life cycle [GO:0019058]; viral process [GO:0016032]	endosomal transport [GO:0016197]; membrane organization [GO:0061024]; multivesicular body sorting pathway [GO:0071985]; protein transport [GO:0015031]; viral budding [GO:0046755]; viral life cycle [GO:0019058]; viral process [GO:0016032]	protein C-terminus binding [GO:0008022]	cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]	GO:0005829; GO:0016197; GO:0010008; GO:0070062; GO:0061024; GO:0071985; GO:0008022; GO:0015031; GO:0046755; GO:0019058; GO:0016032	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15644320}. Endosome membrane {ECO:0000305|PubMed:15644320}; Peripheral membrane protein {ECO:0000305|PubMed:15644320}.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Endosome; Membrane; Polymorphism; Protein transport; Reference proteome; Transport	Alternative sequence (2); Beta strand (1); Chain (1); Frameshift (2); Helix (10); Initiator methionine (1); Modified residue (1); Natural variant (1); Region (3); Sequence conflict (4); Turn (2)
PSB10_HUMAN	P40306	PSB10_HUMAN	reviewed	Proteasome subunit beta type-10 (EC 3.4.25.1) (Low molecular mass protein 10) (Macropain subunit MECl-1) (Multicatalytic endopeptidase complex subunit MECl-1) (Proteasome MECl-1) (Proteasome subunit beta-2i)	PSMB10 LMP10 MECL1	Homo sapiens (Human)	273	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; spermatoproteasome complex [GO:1990111]; endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298]; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cell morphogenesis [GO:0000902]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; humoral immune response [GO:0006959]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell proliferation [GO:0042098]; viral process [GO:0016032]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cell morphogenesis [GO:0000902]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; humoral immune response [GO:0006959]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell proliferation [GO:0042098]; viral process [GO:0016032]	endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; spermatoproteasome complex [GO:1990111]	GO:0006977; GO:0000082; GO:0042098; GO:0031145; GO:0042590; GO:0002479; GO:0002474; GO:0006915; GO:0000902; GO:0034641; GO:0005737; GO:0005829; GO:0004175; GO:0010467; GO:0006959; GO:0045087; GO:0000278; GO:0043066; GO:0090090; GO:0051436; GO:0005654; GO:0090263; GO:0051437; GO:0012501; GO:0010499; GO:0000502; GO:0005839; GO:0043161; GO:0000209; GO:0042981; GO:0006521; GO:0051439; GO:0044281; GO:1990111; GO:0002223; GO:0004298; GO:0016032	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00809}. Nucleus {ECO:0000250}.	Acetylation; Complete proteome; Cytoplasm; Host-virus interaction; Hydrolase; Nucleus; Protease; Proteasome; Reference proteome; Threonine protease; Zymogen	Active site (1); Chain (1); Modified residue (1); Propeptide (1); Site (1)
SYQ_HUMAN	P47897	SYQ_HUMAN	reviewed	Glutamine--tRNA ligase (EC 6.1.1.18) (Glutaminyl-tRNA synthetase) (GlnRS)	QARS	Homo sapiens (Human)	775	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; ATP binding [GO:0005524]; glutamine-tRNA ligase activity [GO:0004819]; brain development [GO:0007420]; gene expression [GO:0010467]; glutaminyl-tRNA aminoacylation [GO:0006425]; tRNA aminoacylation for protein translation [GO:0006418]	brain development [GO:0007420]; gene expression [GO:0010467]; glutaminyl-tRNA aminoacylation [GO:0006425]; tRNA aminoacylation for protein translation [GO:0006418]	ATP binding [GO:0005524]; glutamine-tRNA ligase activity [GO:0004819]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]	GO:0005524; GO:0007420; GO:0005737; GO:0005829; GO:0010467; GO:0004819; GO:0006425; GO:0005759; GO:0006418	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24656866}.	3D-structure; ATP-binding; Acetylation; Alternative splicing; Aminoacyl-tRNA synthetase; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Epilepsy; Ligase; Nucleotide-binding; Phosphoprotein; Primary microcephaly; Protein biosynthesis; Reference proteome	Alternative sequence (1); Binding site (1); Chain (1); Initiator methionine (1); Modified residue (3); Motif (2); Natural variant (4)
T2FA_HUMAN	P35269	T2FA_HUMAN	reviewed	General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74)	GTF2F1 RAP74	Homo sapiens (Human)	517	cell junction [GO:0030054]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIIF complex [GO:0005674]; catalytic activity [GO:0003824]; DNA binding [GO:0003677]; phosphatase activator activity [GO:0019211]; poly(A) RNA binding [GO:0044822]; transcription coactivator activity [GO:0003713]; transcription factor binding [GO:0008134]; 7-methylguanosine mRNA capping [GO:0006370]; gene expression [GO:0010467]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of catalytic activity [GO:0043085]; positive regulation of transcription elongation from RNA polymerase II promoter [GO:0032968]; positive regulation of viral transcription [GO:0050434]; response to virus [GO:0009615]; RNA splicing [GO:0008380]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]; viral process [GO:0016032]	7-methylguanosine mRNA capping [GO:0006370]; gene expression [GO:0010467]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of catalytic activity [GO:0043085]; positive regulation of transcription elongation from RNA polymerase II promoter [GO:0032968]; positive regulation of viral transcription [GO:0050434]; response to virus [GO:0009615]; RNA splicing [GO:0008380]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]; viral process [GO:0016032]	catalytic activity [GO:0003824]; DNA binding [GO:0003677]; phosphatase activator activity [GO:0019211]; poly(A) RNA binding [GO:0044822]; transcription coactivator activity [GO:0003713]; transcription factor binding [GO:0008134]	cell junction [GO:0030054]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIIF complex [GO:0005674]	GO:0006370; GO:0003677; GO:0008380; GO:0003824; GO:0030054; GO:0010467; GO:0000398; GO:0005654; GO:0005634; GO:0019211; GO:0044822; GO:0043085; GO:0032968; GO:0050434; GO:0009615; GO:0003713; GO:0006368; GO:0005674; GO:0008134; GO:0006366; GO:0006367; GO:0016032	SUBCELLULAR LOCATION: Nucleus.	3D-structure; Acetylation; Complete proteome; DNA-binding; Direct protein sequencing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation	Beta strand (11); Chain (1); Compositional bias (1); Helix (10); Initiator methionine (1); Modified residue (18); Mutagenesis (2); Natural variant (1); Sequence conflict (2)
RS25_HUMAN	P62851	RS25_HUMAN	reviewed	40S ribosomal protein S25	RPS25	Homo sapiens (Human)	125	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ribosome [GO:0005840]; small ribosomal subunit [GO:0015935]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; ribosomal small subunit assembly [GO:0000028]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; ribosomal small subunit assembly [GO:0000028]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ribosome [GO:0005840]; small ribosomal subunit [GO:0015935]	GO:0003723; GO:0006614; GO:0044267; GO:0005737; GO:0005829; GO:0022627; GO:0070062; GO:0010467; GO:0000184; GO:0005730; GO:0005634; GO:0044822; GO:0000028; GO:0005840; GO:0015935; GO:0003735; GO:0006412; GO:0006414; GO:0006413; GO:0006415; GO:0019058; GO:0016032; GO:0019083		3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Reference proteome; Ribonucleoprotein; Ribosomal protein	Chain (1); Modified residue (7)
CNDP2_HUMAN	Q96KP4	CNDP2_HUMAN	reviewed	Cytosolic non-specific dipeptidase (EC 3.4.13.18) (CNDP dipeptidase 2) (Glutamate carboxypeptidase-like protein 1) (Peptidase A)	CNDP2 CN2 CPGL PEPA	Homo sapiens (Human)	475	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; carboxypeptidase activity [GO:0004180]; dipeptidase activity [GO:0016805]; metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237]; tripeptidase activity [GO:0034701]; cellular nitrogen compound metabolic process [GO:0034641]; glutathione biosynthetic process [GO:0006750]; glutathione derivative biosynthetic process [GO:1901687]; small molecule metabolic process [GO:0044281]; sulfur amino acid metabolic process [GO:0000096]; xenobiotic metabolic process [GO:0006805]	cellular nitrogen compound metabolic process [GO:0034641]; glutathione biosynthetic process [GO:0006750]; glutathione derivative biosynthetic process [GO:1901687]; small molecule metabolic process [GO:0044281]; sulfur amino acid metabolic process [GO:0000096]; xenobiotic metabolic process [GO:0006805]	carboxypeptidase activity [GO:0004180]; dipeptidase activity [GO:0016805]; metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237]; tripeptidase activity [GO:0034701]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0004180; GO:0034641; GO:0005829; GO:0016805; GO:0070062; GO:0006750; GO:1901687; GO:0046872; GO:0008237; GO:0044281; GO:0000096; GO:0034701; GO:0006805	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12473676, ECO:0000269|PubMed:17121880}.	Acetylation; Alternative splicing; Carboxypeptidase; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Manganese; Metal-binding; Metalloprotease; Phosphoprotein; Polymorphism; Protease; Reference proteome	Active site (2); Alternative sequence (1); Binding site (6); Chain (1); Initiator methionine (1); Metal binding (6); Modified residue (3); Natural variant (1); Region (1); Sequence conflict (2); Site (1)
PYR1_HUMAN	P27708	PYR1_HUMAN	reviewed	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)]	CAD	Homo sapiens (Human)	2225	cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein complex [GO:0043234]; terminal bouton [GO:0043195]; aspartate binding [GO:0070335]; aspartate carbamoyltransferase activity [GO:0004070]; ATP binding [GO:0005524]; carbamoyl-phosphate synthase (ammonia) activity [GO:0004087]; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [GO:0004088]; dihydroorotase activity [GO:0004151]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; protein kinase activity [GO:0004672]; zinc ion binding [GO:0008270]; 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]; arginine biosynthetic process [GO:0006526]; cellular response to drug [GO:0035690]; cellular response to epidermal growth factor stimulus [GO:0071364]; drug metabolic process [GO:0017144]; female pregnancy [GO:0007565]; glutamine metabolic process [GO:0006541]; heart development [GO:0007507]; lactation [GO:0007595]; liver development [GO:0001889]; nucleobase-containing small molecule metabolic process [GO:0055086]; organ regeneration [GO:0031100]; peptidyl-threonine phosphorylation [GO:0018107]; protein autophosphorylation [GO:0046777]; pyrimidine nucleobase metabolic process [GO:0006206]; pyrimidine nucleoside biosynthetic process [GO:0046134]; response to amine [GO:0014075]; response to caffeine [GO:0031000]; response to cortisol [GO:0051414]; response to testosterone [GO:0033574]; small molecule metabolic process [GO:0044281]; urea cycle [GO:0000050]; UTP biosynthetic process [GO:0006228]	'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]; arginine biosynthetic process [GO:0006526]; cellular response to drug [GO:0035690]; cellular response to epidermal growth factor stimulus [GO:0071364]; drug metabolic process [GO:0017144]; female pregnancy [GO:0007565]; glutamine metabolic process [GO:0006541]; heart development [GO:0007507]; lactation [GO:0007595]; liver development [GO:0001889]; nucleobase-containing small molecule metabolic process [GO:0055086]; organ regeneration [GO:0031100]; peptidyl-threonine phosphorylation [GO:0018107]; protein autophosphorylation [GO:0046777]; pyrimidine nucleobase metabolic process [GO:0006206]; pyrimidine nucleoside biosynthetic process [GO:0046134]; response to amine [GO:0014075]; response to caffeine [GO:0031000]; response to cortisol [GO:0051414]; response to testosterone [GO:0033574]; small molecule metabolic process [GO:0044281]; urea cycle [GO:0000050]; UTP biosynthetic process [GO:0006228]	aspartate binding [GO:0070335]; aspartate carbamoyltransferase activity [GO:0004070]; ATP binding [GO:0005524]; carbamoyl-phosphate synthase (ammonia) activity [GO:0004087]; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [GO:0004088]; dihydroorotase activity [GO:0004151]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; protein kinase activity [GO:0004672]; zinc ion binding [GO:0008270]	cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein complex [GO:0043234]; terminal bouton [GO:0043195]	GO:0044205; GO:0006207; GO:0005524; GO:0006228; GO:0006526; GO:0070335; GO:0004070; GO:0004087; GO:0004088; GO:0042995; GO:0035690; GO:0071364; GO:0005737; GO:0005829; GO:0004151; GO:0017144; GO:0019899; GO:0070062; GO:0007565; GO:0006541; GO:0007507; GO:0042802; GO:0007595; GO:0001889; GO:0016020; GO:0043025; GO:0016363; GO:0055086; GO:0005654; GO:0005634; GO:0031100; GO:0018107; GO:0005886; GO:0046777; GO:0043234; GO:0004672; GO:0006206; GO:0046134; GO:0014075; GO:0031000; GO:0051414; GO:0033574; GO:0044281; GO:0043195; GO:0000050; GO:0008270	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15890648}. Nucleus {ECO:0000269|PubMed:15890648}. Note=Cytosolic and unphosphorylated in resting cells, translocates to the nucleus in response to EGF stimulation, nuclear import promotes optimal cell growth.	3D-structure; ATP-binding; Acetylation; Allosteric enzyme; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Ligase; Metal-binding; Multifunctional enzyme; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Pyrimidine biosynthesis; Reference proteome; Repeat; Transferase; Zinc	Active site (3); Beta strand (14); Binding site (5); Chain (1); Domain (3); Helix (17); Initiator methionine (1); Metal binding (10); Modified residue (10); Mutagenesis (15); Natural variant (2); Region (8); Sequence conflict (6); Turn (5)
DPH1_HUMAN	Q9BZG8	DPH1_HUMAN	reviewed	Diphthamide biosynthesis protein 1 (DPH1 homolog) (HsDph1) (Diphthamide biosynthesis protein 2 homolog-like 1) (DPH-like 1) (DPH2-like 1) (Diphthamide biosynthesis protein 2-like) (Ovarian cancer-associated gene 1 protein)	DPH1 DPH2L DPH2L1 OVCA1	Homo sapiens (Human)	443	cytosol [GO:0005829]; nucleus [GO:0005634]; cell proliferation [GO:0008283]; cellular protein metabolic process [GO:0044267]; peptidyl-diphthamide biosynthetic process from peptidyl-histidine [GO:0017183]; post-translational protein modification [GO:0043687]	cell proliferation [GO:0008283]; cellular protein metabolic process [GO:0044267]; peptidyl-diphthamide biosynthetic process from peptidyl-histidine [GO:0017183]; post-translational protein modification [GO:0043687]		cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0008283; GO:0044267; GO:0005829; GO:0005634; GO:0017183; GO:0043687	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10519411}. Cytoplasm {ECO:0000269|PubMed:10519411}. Note=Punctate, primarily perinuclear localization.	Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Polymorphism; Reference proteome; Tumor suppressor	Alternative sequence (2); Chain (1); Natural variant (6); Sequence conflict (4)
LSM5_HUMAN	Q9Y4Y9	LSM5_HUMAN	reviewed	U6 snRNA-associated Sm-like protein LSm5	LSM5	Homo sapiens (Human)	91	cytosol [GO:0005829]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; RNA binding [GO:0003723]; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [GO:0043928]; gene expression [GO:0010467]; mRNA processing [GO:0006397]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; RNA splicing [GO:0008380]	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [GO:0043928]; gene expression [GO:0010467]; mRNA processing [GO:0006397]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; RNA splicing [GO:0008380]	RNA binding [GO:0003723]	cytosol [GO:0005829]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]	GO:0003723; GO:0008380; GO:0005829; GO:0043928; GO:0010467; GO:0006397; GO:0000288; GO:0005634; GO:0005681	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.	Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Nucleus; RNA-binding; Reference proteome; Ribonucleoprotein; Spliceosome; mRNA processing; mRNA splicing	Alternative sequence (1); Chain (1); Initiator methionine (1); Modified residue (1)
B8ZZF8_HUMAN	B8ZZF8	B8ZZF8_HUMAN	unreviewed	U6 snRNA-associated Sm-like protein LSm5	LSM5	Homo sapiens (Human)	64							Complete proteome; Proteomics identification; Reference proteome	
RL22_HUMAN	P35268	RL22_HUMAN	reviewed	60S ribosomal protein L22 (EBER-associated protein) (EAP) (Epstein-Barr virus small RNA-associated protein) (Heparin-binding protein HBp15)	RPL22	Homo sapiens (Human)	128	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]; heparin binding [GO:0008201]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; alpha-beta T cell differentiation [GO:0046632]; cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	alpha-beta T cell differentiation [GO:0046632]; cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	heparin binding [GO:0008201]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]	GO:0003723; GO:0006614; GO:0046632; GO:0044267; GO:0005737; GO:0005829; GO:0022625; GO:0070062; GO:0005925; GO:0010467; GO:0008201; GO:0000184; GO:0005634; GO:0044822; GO:0030529; GO:0003735; GO:0006412; GO:0006414; GO:0006413; GO:0006415; GO:0019058; GO:0016032; GO:0019083		3D-structure; Complete proteome; Direct protein sequencing; Heparin-binding; RNA-binding; Reference proteome; Ribonucleoprotein; Ribosomal protein	Chain (1); Compositional bias (1); Initiator methionine (1); Modified residue (1)
KLC1_HUMAN	Q07866	KLC1_HUMAN	reviewed	Kinesin light chain 1 (KLC 1)	KLC1 KLC KNS2	Homo sapiens (Human)	573	cytoplasmic membrane-bounded vesicle [GO:0016023]; cytosol [GO:0005829]; growth cone [GO:0030426]; kinesin complex [GO:0005871]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule motor activity [GO:0003777]; motor activity [GO:0003774]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; blood coagulation [GO:0007596]; metabolic process [GO:0008152]; microtubule-based movement [GO:0007018]; small GTPase mediated signal transduction [GO:0007264]; stress granule disassembly [GO:0035617]; viral process [GO:0016032]	antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; blood coagulation [GO:0007596]; metabolic process [GO:0008152]; microtubule-based movement [GO:0007018]; small GTPase mediated signal transduction [GO:0007264]; stress granule disassembly [GO:0035617]; viral process [GO:0016032]	microtubule motor activity [GO:0003777]; motor activity [GO:0003774]	cytoplasmic membrane-bounded vesicle [GO:0016023]; cytosol [GO:0005829]; growth cone [GO:0030426]; kinesin complex [GO:0005871]; membrane [GO:0016020]; microtubule [GO:0005874]	GO:0019886; GO:0007596; GO:0016023; GO:0005829; GO:0030426; GO:0005871; GO:0016020; GO:0008152; GO:0005874; GO:0003777; GO:0007018; GO:0003774; GO:0007264; GO:0035617; GO:0016032	SUBCELLULAR LOCATION: Cell projection, growth cone {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000305|PubMed:14970196}.	3D-structure; Alternative splicing; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Host-virus interaction; Microtubule; Motor protein; Phosphoprotein; Reference proteome; Repeat; TPR repeat	Alternative sequence (7); Beta strand (2); Chain (1); Coiled coil (1); Erroneous initiation (12); Helix (13); Modified residue (3); Mutagenesis (2); Repeat (6); Sequence conflict (13); Turn (2)
H3BNW0_HUMAN	H3BNW0	H3BNW0_HUMAN	unreviewed	THUMP domain-containing protein 1	THUMPD1	Homo sapiens (Human)	145							Complete proteome; Proteomics identification; Reference proteome	
THUM1_HUMAN	Q9NXG2	THUM1_HUMAN	reviewed	THUMP domain-containing protein 1	THUMPD1	Homo sapiens (Human)	353	poly(A) RNA binding [GO:0044822]		poly(A) RNA binding [GO:0044822]		GO:0044822		3D-structure; Acetylation; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome	Beta strand (4); Chain (1); Domain (1); Helix (2); Initiator methionine (1); Modified residue (4); Natural variant (1); Sequence conflict (3)
ECHB_HUMAN	P55084	ECHB_HUMAN	reviewed	Trifunctional enzyme subunit beta, mitochondrial (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)]	HADHB MSTP029	Homo sapiens (Human)	474	endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; mitochondrial envelope [GO:0005740]; mitochondrial fatty acid beta-oxidation multienzyme complex [GO:0016507]; mitochondrial inner membrane [GO:0005743]; mitochondrial nucleoid [GO:0042645]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; 3-hydroxyacyl-CoA dehydrogenase activity [GO:0003857]; acetyl-CoA C-acyltransferase activity [GO:0003988]; enoyl-CoA hydratase activity [GO:0004300]; fatty-acyl-CoA binding [GO:0000062]; long-chain-3-hydroxyacyl-CoA dehydrogenase activity [GO:0016509]; long-chain-enoyl-CoA hydratase activity [GO:0016508]; NAD binding [GO:0051287]; poly(A) RNA binding [GO:0044822]; cardiolipin acyl-chain remodeling [GO:0035965]; cellular lipid metabolic process [GO:0044255]; fatty acid beta-oxidation [GO:0006635]; glycerophospholipid biosynthetic process [GO:0046474]; phospholipid metabolic process [GO:0006644]; small molecule metabolic process [GO:0044281]	cardiolipin acyl-chain remodeling [GO:0035965]; cellular lipid metabolic process [GO:0044255]; fatty acid beta-oxidation [GO:0006635]; glycerophospholipid biosynthetic process [GO:0046474]; phospholipid metabolic process [GO:0006644]; small molecule metabolic process [GO:0044281]	3-hydroxyacyl-CoA dehydrogenase activity [GO:0003857]; acetyl-CoA C-acyltransferase activity [GO:0003988]; enoyl-CoA hydratase activity [GO:0004300]; fatty-acyl-CoA binding [GO:0000062]; long-chain-3-hydroxyacyl-CoA dehydrogenase activity [GO:0016509]; long-chain-enoyl-CoA hydratase activity [GO:0016508]; NAD binding [GO:0051287]; poly(A) RNA binding [GO:0044822]	endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; mitochondrial envelope [GO:0005740]; mitochondrial fatty acid beta-oxidation multienzyme complex [GO:0016507]; mitochondrial inner membrane [GO:0005743]; mitochondrial nucleoid [GO:0042645]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	GO:0003857; GO:0051287; GO:0003988; GO:0035965; GO:0044255; GO:0005783; GO:0004300; GO:0070062; GO:0006635; GO:0000062; GO:0046474; GO:0016509; GO:0016508; GO:0005740; GO:0016507; GO:0005743; GO:0042645; GO:0005741; GO:0005739; GO:0006644; GO:0044822; GO:0044281	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:21527675}. Mitochondrion inner membrane {ECO:0000269|PubMed:21527675}. Mitochondrion outer membrane {ECO:0000269|PubMed:21527675}. Endoplasmic reticulum {ECO:0000269|PubMed:21527675}.	Acetylation; Acyltransferase; Alternative splicing; Complete proteome; Direct protein sequencing; Disease mutation; Endoplasmic reticulum; Fatty acid metabolism; Lipid metabolism; Membrane; Mitochondrion; Mitochondrion inner membrane; Mitochondrion outer membrane; Polymorphism; Reference proteome; Transferase; Transit peptide	Active site (3); Alternative sequence (1); Chain (1); Erroneous gene model prediction (1); Modified residue (14); Natural variant (18); Sequence conflict (5); Transit peptide (1)
PGM2_HUMAN	Q96G03	PGM2_HUMAN	reviewed	Phosphoglucomutase-2 (PGM 2) (EC 5.4.2.2) (Glucose phosphomutase 2) (Phosphodeoxyribomutase) (Phosphopentomutase) (EC 5.4.2.7)	PGM2 MSTP006	Homo sapiens (Human)	612	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; magnesium ion binding [GO:0000287]; phosphoglucomutase activity [GO:0004614]; phosphopentomutase activity [GO:0008973]; carbohydrate metabolic process [GO:0005975]; deoxyribose phosphate catabolic process [GO:0046386]; galactose catabolic process [GO:0019388]; glucose metabolic process [GO:0006006]; glycogen biosynthetic process [GO:0005978]; glycogen catabolic process [GO:0005980]; small molecule metabolic process [GO:0044281]	carbohydrate metabolic process [GO:0005975]; deoxyribose phosphate catabolic process [GO:0046386]; galactose catabolic process [GO:0019388]; glucose metabolic process [GO:0006006]; glycogen biosynthetic process [GO:0005978]; glycogen catabolic process [GO:0005980]; small molecule metabolic process [GO:0044281]	magnesium ion binding [GO:0000287]; phosphoglucomutase activity [GO:0004614]; phosphopentomutase activity [GO:0008973]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0005975; GO:0005829; GO:0046386; GO:0070062; GO:0019388; GO:0006006; GO:0005978; GO:0005980; GO:0000287; GO:0004614; GO:0008973; GO:0044281	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.	Acetylation; Alternative splicing; Carbohydrate metabolism; Complete proteome; Cytoplasm; Direct protein sequencing; Glucose metabolism; Isomerase; Magnesium; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome	Active site (1); Alternative sequence (4); Binding site (4); Chain (1); Initiator methionine (1); Metal binding (4); Modified residue (2); Natural variant (2); Region (3); Sequence conflict (4)
PMM2_HUMAN	O15305	PMM2_HUMAN	reviewed	Phosphomannomutase 2 (PMM 2) (EC 5.4.2.8)	PMM2	Homo sapiens (Human)	246	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; neuronal cell body [GO:0043025]; phosphomannomutase activity [GO:0004615]; cellular protein metabolic process [GO:0044267]; dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; GDP-mannose biosynthetic process [GO:0009298]; mannose biosynthetic process [GO:0019307]; post-translational protein modification [GO:0043687]; protein glycosylation [GO:0006486]; protein N-linked glycosylation via asparagine [GO:0018279]	cellular protein metabolic process [GO:0044267]; dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; GDP-mannose biosynthetic process [GO:0009298]; mannose biosynthetic process [GO:0019307]; post-translational protein modification [GO:0043687]; protein glycosylation [GO:0006486]; protein N-linked glycosylation via asparagine [GO:0018279]	phosphomannomutase activity [GO:0004615]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; neuronal cell body [GO:0043025]	GO:0009298; GO:0044267; GO:0005829; GO:0006488; GO:0070062; GO:0019307; GO:0043025; GO:0004615; GO:0043687; GO:0018279; GO:0006486	SUBCELLULAR LOCATION: Cytoplasm.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Congenital disorder of glycosylation; Cytoplasm; Disease mutation; Isomerase; Polymorphism; Reference proteome	Active site (2); Alternative sequence (2); Beta strand (11); Binding site (6); Chain (1); Helix (11); Initiator methionine (1); Modified residue (2); Natural variant (71); Turn (5)
GLGB_HUMAN	Q04446	GLGB_HUMAN	reviewed	1,4-alpha-glucan-branching enzyme (EC 2.4.1.18) (Brancher enzyme) (Glycogen-branching enzyme)	GBE1	Homo sapiens (Human)	702	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; 1,4-alpha-glucan branching enzyme activity [GO:0003844]; cation binding [GO:0043169]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]; carbohydrate metabolic process [GO:0005975]; generation of precursor metabolites and energy [GO:0006091]; glucose metabolic process [GO:0006006]; glycogen biosynthetic process [GO:0005978]; glycogen metabolic process [GO:0005977]; small molecule metabolic process [GO:0044281]	carbohydrate metabolic process [GO:0005975]; generation of precursor metabolites and energy [GO:0006091]; glucose metabolic process [GO:0006006]; glycogen biosynthetic process [GO:0005978]; glycogen metabolic process [GO:0005977]; small molecule metabolic process [GO:0044281]	1,4-alpha-glucan branching enzyme activity [GO:0003844]; cation binding [GO:0043169]; hydrolase activity, hydrolyzing O-glycosyl compounds [GO:0004553]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0003844; GO:0005975; GO:0043169; GO:0005829; GO:0070062; GO:0006091; GO:0006006; GO:0005978; GO:0005977; GO:0004553; GO:0044281		3D-structure; Acetylation; Complete proteome; Disease mutation; Glycogen biosynthesis; Glycogen storage disease; Glycosyltransferase; Neuropathy; Phosphoprotein; Polymorphism; Reference proteome; Transferase	Active site (2); Beta strand (30); Chain (1); Helix (26); Initiator methionine (1); Modified residue (2); Natural variant (12); Sequence conflict (1); Turn (4)
LSM12_HUMAN	Q3MHD2	LSM12_HUMAN	reviewed	Protein LSM12 homolog	LSM12	Homo sapiens (Human)	195							Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Phosphoprotein; Polymorphism; Reference proteome	Alternative sequence (1); Chain (1); Initiator methionine (1); Modified residue (2); Natural variant (2)
K7ELG9_HUMAN	K7ELG9	K7ELG9_HUMAN	unreviewed	Protein LSM12 homolog	LSM12	Homo sapiens (Human)	230							Complete proteome; Proteomics identification; Reference proteome	
Q86WV7_HUMAN	Q86WV7	Q86WV7_HUMAN	unreviewed	CCDC43 protein (Coiled-coil domain-containing protein 43)	CCDC43	Homo sapiens (Human)	227							Complete proteome; Proteomics identification; Reference proteome	
E5RGS4_HUMAN	E5RGS4	E5RGS4_HUMAN	unreviewed	Prefoldin subunit 1	PFDN1	Homo sapiens (Human)	117	prefoldin complex [GO:0016272]; protein folding [GO:0006457]	protein folding [GO:0006457]		prefoldin complex [GO:0016272]	GO:0016272; GO:0006457		Complete proteome; Proteomics identification; Reference proteome	
E9PC74_HUMAN	E9PC74	E9PC74_HUMAN	unreviewed	Translation initiation factor eIF-2B subunit epsilon	EIF2B5	Homo sapiens (Human)	705							Complete proteome; Proteomics identification; Reference proteome	
PRP6_HUMAN	O94906	PRP6_HUMAN	reviewed	Pre-mRNA-processing factor 6 (Androgen receptor N-terminal domain-transactivating protein 1) (ANT-1) (PRP6 homolog) (U5 snRNP-associated 102 kDa protein) (U5-102 kDa protein)	PRPF6 C20orf14	Homo sapiens (Human)	941	catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U4/U6 snRNP [GO:0071001]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; androgen receptor binding [GO:0050681]; poly(A) RNA binding [GO:0044822]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]; gene expression [GO:0010467]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; RNA localization [GO:0006403]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal complex assembly [GO:0000245]; spliceosomal tri-snRNP complex assembly [GO:0000244]	gene expression [GO:0010467]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; RNA localization [GO:0006403]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal complex assembly [GO:0000245]; spliceosomal tri-snRNP complex assembly [GO:0000244]	androgen receptor binding [GO:0050681]; poly(A) RNA binding [GO:0044822]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]	catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U4/U6 snRNP [GO:0071001]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]	GO:0003723; GO:0006403; GO:0008380; GO:0000375; GO:0071001; GO:0046540; GO:0005682; GO:0050681; GO:0071013; GO:0010467; GO:0000398; GO:0016020; GO:0016607; GO:0005654; GO:0005634; GO:0044822; GO:0045944; GO:0043021; GO:0005681; GO:0000245; GO:0000244; GO:0003713	SUBCELLULAR LOCATION: Nucleus, nucleoplasm. Nucleus speckle. Note=Localized in splicing speckles.	Alternative splicing; Complete proteome; Direct protein sequencing; Disease mutation; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Retinitis pigmentosa; Spliceosome; mRNA processing; mRNA splicing	Alternative sequence (1); Chain (1); Compositional bias (1); Modified residue (4); Natural variant (2); Repeat (9); Sequence conflict (4)
RAN_HUMAN	P62826	RAN_HUMAN	reviewed	GTP-binding nuclear protein Ran (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)	RAN ARA24 OK/SW-cl.81	Homo sapiens (Human)	216	centriole [GO:0005814]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; nuclear pore [GO:0005643]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; recycling endosome [GO:0055037]; RNA nuclear export complex [GO:0042565]; androgen receptor binding [GO:0050681]; chromatin binding [GO:0003682]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; poly(A) RNA binding [GO:0044822]; transcription coactivator activity [GO:0003713]; actin cytoskeleton organization [GO:0030036]; androgen receptor signaling pathway [GO:0030521]; cell division [GO:0051301]; cellular protein complex localization [GO:0034629]; DNA metabolic process [GO:0006259]; gene expression [GO:0010467]; intracellular transport of virus [GO:0075733]; mitotic nuclear division [GO:0007067]; mitotic spindle organization [GO:0007052]; positive regulation of protein binding [GO:0032092]; positive regulation of transcription, DNA-templated [GO:0045893]; pre-miRNA export from nucleus [GO:0035281]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]; protein import into nucleus, translocation [GO:0000060]; protein localization to nucleolus [GO:1902570]; ribosomal large subunit export from nucleus [GO:0000055]; ribosomal small subunit export from nucleus [GO:0000056]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]; small molecule metabolic process [GO:0044281]; spermatid development [GO:0007286]; viral life cycle [GO:0019058]; viral process [GO:0016032]	actin cytoskeleton organization [GO:0030036]; androgen receptor signaling pathway [GO:0030521]; cell division [GO:0051301]; cellular protein complex localization [GO:0034629]; DNA metabolic process [GO:0006259]; gene expression [GO:0010467]; intracellular transport of virus [GO:0075733]; mitotic nuclear division [GO:0007067]; mitotic spindle organization [GO:0007052]; positive regulation of protein binding [GO:0032092]; positive regulation of transcription, DNA-templated [GO:0045893]; pre-miRNA export from nucleus [GO:0035281]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]; protein import into nucleus, translocation [GO:0000060]; protein localization to nucleolus [GO:1902570]; ribosomal large subunit export from nucleus [GO:0000055]; ribosomal small subunit export from nucleus [GO:0000056]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]; small molecule metabolic process [GO:0044281]; spermatid development [GO:0007286]; viral life cycle [GO:0019058]; viral process [GO:0016032]	androgen receptor binding [GO:0050681]; chromatin binding [GO:0003682]; GDP binding [GO:0019003]; GTPase activity [GO:0003924]; GTP binding [GO:0005525]; poly(A) RNA binding [GO:0044822]; transcription coactivator activity [GO:0003713]	centriole [GO:0005814]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; nuclear pore [GO:0005643]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; recycling endosome [GO:0055037]; RNA nuclear export complex [GO:0042565]	GO:0006259; GO:0019003; GO:0005525; GO:0003924; GO:0042565; GO:0030036; GO:0050681; GO:0030521; GO:0051301; GO:0034629; GO:0005814; GO:0003682; GO:0005737; GO:0005829; GO:0070062; GO:0010467; GO:0075733; GO:0042470; GO:0016020; GO:0030496; GO:0007067; GO:0007052; GO:0005643; GO:0005730; GO:0005654; GO:0005634; GO:0044822; GO:0032092; GO:0045893; GO:0035281; GO:0006611; GO:0006606; GO:0000060; GO:1902570; GO:0055037; GO:0000055; GO:0000056; GO:0007165; GO:0007264; GO:0044281; GO:0007286; GO:0003713; GO:0019058; GO:0016032	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Melanosome. Note=Predominantly nuclear during interphase (By similarity). Becomes dispersed throughout the cytoplasm during mitosis. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000250}.	3D-structure; Acetylation; Cell cycle; Cell division; Complete proteome; Cytoplasm; Direct protein sequencing; GTP-binding; Host-virus interaction; Isopeptide bond; Mitosis; Nucleotide-binding; Nucleus; Polymorphism; Protein transport; Reference proteome; Transport; Ubl conjugation	Beta strand (12); Chain (1); Cross-link (1); Erroneous initiation (1); Helix (12); Initiator methionine (1); Modified residue (6); Mutagenesis (4); Natural variant (1); Nucleotide binding (3); Sequence conflict (2); Turn (5)
ATPB_HUMAN	P06576	ATPB_HUMAN	reviewed	ATP synthase subunit beta, mitochondrial (EC 3.6.3.14)	ATP5B ATPMB ATPSB	Homo sapiens (Human)	529	cell surface [GO:0009986]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrial nucleoid [GO:0042645]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrial proton-transporting ATP synthase, catalytic core [GO:0005754]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; MHC class I protein binding [GO:0042288]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; transmembrane transporter activity [GO:0022857]; transporter activity [GO:0005215]; angiogenesis [GO:0001525]; ATP biosynthetic process [GO:0006754]; ATP hydrolysis coupled proton transport [GO:0015991]; cellular metabolic process [GO:0044237]; generation of precursor metabolites and energy [GO:0006091]; lipid metabolic process [GO:0006629]; mitochondrial ATP synthesis coupled proton transport [GO:0042776]; mitochondrion organization [GO:0007005]; negative regulation of cell adhesion involved in substrate-bound cell migration [GO:0006933]; organelle organization [GO:0006996]; osteoblast differentiation [GO:0001649]; proton transport [GO:0015992]; regulation of intracellular pH [GO:0051453]; respiratory electron transport chain [GO:0022904]; small molecule metabolic process [GO:0044281]	angiogenesis [GO:0001525]; ATP biosynthetic process [GO:0006754]; ATP hydrolysis coupled proton transport [GO:0015991]; cellular metabolic process [GO:0044237]; generation of precursor metabolites and energy [GO:0006091]; lipid metabolic process [GO:0006629]; mitochondrial ATP synthesis coupled proton transport [GO:0042776]; mitochondrion organization [GO:0007005]; negative regulation of cell adhesion involved in substrate-bound cell migration [GO:0006933]; organelle organization [GO:0006996]; osteoblast differentiation [GO:0001649]; proton transport [GO:0015992]; regulation of intracellular pH [GO:0051453]; respiratory electron transport chain [GO:0022904]; small molecule metabolic process [GO:0044281]	ATP binding [GO:0005524]; MHC class I protein binding [GO:0042288]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; transmembrane transporter activity [GO:0022857]; transporter activity [GO:0005215]	cell surface [GO:0009986]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrial nucleoid [GO:0042645]; mitochondrial proton-transporting ATP synthase, catalytic core [GO:0005754]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005524; GO:0006754; GO:0015991; GO:0042288; GO:0001525; GO:0009986; GO:0044237; GO:0070062; GO:0006091; GO:0006629; GO:0016020; GO:0042776; GO:0005759; GO:0031966; GO:0042645; GO:0005753; GO:0005754; GO:0005739; GO:0007005; GO:0006933; GO:0005634; GO:0006996; GO:0001649; GO:0005886; GO:0015992; GO:0046933; GO:0046961; GO:0051453; GO:0022904; GO:0044281; GO:0022857; GO:0005215	SUBCELLULAR LOCATION: Mitochondrion. Mitochondrion inner membrane. Note=Peripheral membrane protein.	ATP synthesis; ATP-binding; Acetylation; CF(1); Complete proteome; Direct protein sequencing; Glycoprotein; Hydrogen ion transport; Hydrolase; Ion transport; Membrane; Mitochondrion; Mitochondrion inner membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Transit peptide; Transport	Chain (1); Glycosylation (1); Modified residue (18); Natural variant (1); Nucleotide binding (1); Sequence conflict (8); Transit peptide (1)
TIF1B_HUMAN	Q13263	TIF1B_HUMAN	reviewed	Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 6.3.2.-) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (Tripartite motif-containing protein 28)	TRIM28 KAP1 RNF96 TIF1B	Homo sapiens (Human)	835	nuclear euchromatin [GO:0005719]; nuclear heterochromatin [GO:0005720]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription factor complex [GO:0090575]; chromo shadow domain binding [GO:0070087]; DNA binding [GO:0003677]; Krueppel-associated box domain binding [GO:0035851]; ligase activity [GO:0016874]; poly(A) RNA binding [GO:0044822]; protein kinase activity [GO:0004672]; sequence-specific DNA binding [GO:0043565]; sequence-specific DNA binding transcription factor activity [GO:0003700]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; convergent extension involved in axis elongation [GO:0060028]; DNA methylation involved in embryo development [GO:0043045]; DNA repair [GO:0006281]; embryo implantation [GO:0007566]; embryonic placenta morphogenesis [GO:0060669]; epithelial to mesenchymal transition [GO:0001837]; gene expression [GO:0010467]; innate immune response [GO:0045087]; negative regulation of DNA demethylation [GO:1901536]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of viral release from host cell [GO:1902187]; positive regulation of DNA repair [GO:0045739]; positive regulation of transcription factor import into nucleus [GO:0042993]; positive regulation of transcription, DNA-templated [GO:0045893]; protein autophosphorylation [GO:0046777]; protein oligomerization [GO:0051259]; protein sumoylation [GO:0016925]; protein ubiquitination [GO:0016567]; regulation of genetic imprinting [GO:2000653]; transcription initiation from RNA polymerase II promoter [GO:0006367]	convergent extension involved in axis elongation [GO:0060028]; DNA methylation involved in embryo development [GO:0043045]; DNA repair [GO:0006281]; embryo implantation [GO:0007566]; embryonic placenta morphogenesis [GO:0060669]; epithelial to mesenchymal transition [GO:0001837]; gene expression [GO:0010467]; innate immune response [GO:0045087]; negative regulation of DNA demethylation [GO:1901536]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of viral release from host cell [GO:1902187]; positive regulation of DNA repair [GO:0045739]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription factor import into nucleus [GO:0042993]; protein autophosphorylation [GO:0046777]; protein oligomerization [GO:0051259]; protein sumoylation [GO:0016925]; protein ubiquitination [GO:0016567]; regulation of genetic imprinting [GO:2000653]; transcription initiation from RNA polymerase II promoter [GO:0006367]	chromo shadow domain binding [GO:0070087]; DNA binding [GO:0003677]; Krueppel-associated box domain binding [GO:0035851]; ligase activity [GO:0016874]; poly(A) RNA binding [GO:0044822]; protein kinase activity [GO:0004672]; sequence-specific DNA binding [GO:0043565]; sequence-specific DNA binding transcription factor activity [GO:0003700]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	nuclear euchromatin [GO:0005719]; nuclear heterochromatin [GO:0005720]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription factor complex [GO:0090575]	GO:0003677; GO:0043045; GO:0006281; GO:0035851; GO:0090575; GO:0070087; GO:0060028; GO:0007566; GO:0060669; GO:0001837; GO:0010467; GO:0045087; GO:0016874; GO:1901536; GO:0000122; GO:0045892; GO:1902187; GO:0005719; GO:0005720; GO:0005654; GO:0005634; GO:0044822; GO:0045739; GO:0042993; GO:0045893; GO:0046777; GO:0004672; GO:0051259; GO:0016925; GO:0016567; GO:2000653; GO:0043565; GO:0003700; GO:0003713; GO:0003714; GO:0006367; GO:0031625; GO:0004842; GO:0008270	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10330177, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:9016654}. Note=Associated with centromeric heterochromatin during cell differentiation through CBX1. {ECO:0000250}.	3D-structure; Acetylation; Alternative splicing; Citrullination; Complete proteome; Direct protein sequencing; Isopeptide bond; Ligase; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Ubl conjugation; Ubl conjugation pathway; Zinc; Zinc-finger	Alternative sequence (1); Beta strand (12); Chain (1); Compositional bias (2); Cross-link (5); Domain (1); Helix (6); Initiator methionine (1); Modified residue (26); Motif (1); Mutagenesis (23); Natural variant (1); Region (5); Sequence conflict (1); Turn (5); Zinc finger (4)
E5RFN1_HUMAN	E5RFN1	E5RFN1_HUMAN	unreviewed	Kelch-like protein 7	KLHL7	Homo sapiens (Human)	40							Complete proteome; Proteomics identification; Reference proteome	
THOP1_HUMAN	P52888	THOP1_HUMAN	reviewed	Thimet oligopeptidase (EC 3.4.24.15) (Endopeptidase 24.15) (MP78)	THOP1	Homo sapiens (Human)	689	cytoplasm [GO:0005737]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; peptide binding [GO:0042277]; intracellular signal transduction [GO:0035556]; peptide metabolic process [GO:0006518]	intracellular signal transduction [GO:0035556]; peptide metabolic process [GO:0006518]	metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; peptide binding [GO:0042277]	cytoplasm [GO:0005737]	GO:0005737; GO:0035556; GO:0046872; GO:0004222; GO:0042277; GO:0006518	SUBCELLULAR LOCATION: Cytoplasm.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Metal-binding; Metalloprotease; Phosphoprotein; Protease; Reference proteome; Zinc	Active site (1); Alternative sequence (2); Beta strand (8); Chain (1); Helix (34); Metal binding (3); Modified residue (3); Turn (10)
MP2K7_HUMAN	O14733	MP2K7_HUMAN	reviewed	Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2)	MAP2K7 JNKK2 MEK7 MKK7 PRKMK7 SKK4	Homo sapiens (Human)	419	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular [GO:0005622]; nucleus [GO:0005634]; ATP binding [GO:0005524]; enzyme binding [GO:0019899]; JUN kinase kinase activity [GO:0008545]; magnesium ion binding [GO:0000287]; MAP kinase kinase activity [GO:0004708]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; activation of JUN kinase activity [GO:0007257]; apoptotic process [GO:0006915]; cellular response to sorbitol [GO:0072709]; Fc-epsilon receptor signaling pathway [GO:0038095]; innate immune response [GO:0045087]; JNK cascade [GO:0007254]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; MyD88-independent toll-like receptor signaling pathway [GO:0002756]; positive regulation of neuron apoptotic process [GO:0043525]; response to heat [GO:0009408]; response to osmotic stress [GO:0006970]; response to tumor necrosis factor [GO:0034612]; response to UV [GO:0009411]; signal transduction [GO:0007165]; stress-activated MAPK cascade [GO:0051403]; toll-like receptor 10 signaling pathway [GO:0034166]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 5 signaling pathway [GO:0034146]; toll-like receptor 9 signaling pathway [GO:0034162]; toll-like receptor signaling pathway [GO:0002224]; toll-like receptor TLR1:TLR2 signaling pathway [GO:0038123]; toll-like receptor TLR6:TLR2 signaling pathway [GO:0038124]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]	activation of JUN kinase activity [GO:0007257]; apoptotic process [GO:0006915]; cellular response to sorbitol [GO:0072709]; Fc-epsilon receptor signaling pathway [GO:0038095]; innate immune response [GO:0045087]; JNK cascade [GO:0007254]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; MyD88-independent toll-like receptor signaling pathway [GO:0002756]; positive regulation of neuron apoptotic process [GO:0043525]; response to heat [GO:0009408]; response to osmotic stress [GO:0006970]; response to tumor necrosis factor [GO:0034612]; response to UV [GO:0009411]; signal transduction [GO:0007165]; stress-activated MAPK cascade [GO:0051403]; toll-like receptor 10 signaling pathway [GO:0034166]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 5 signaling pathway [GO:0034146]; toll-like receptor 9 signaling pathway [GO:0034162]; toll-like receptor signaling pathway [GO:0002224]; toll-like receptor TLR1:TLR2 signaling pathway [GO:0038123]; toll-like receptor TLR6:TLR2 signaling pathway [GO:0038124]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]	ATP binding [GO:0005524]; enzyme binding [GO:0019899]; JUN kinase kinase activity [GO:0008545]; magnesium ion binding [GO:0000287]; MAP kinase kinase activity [GO:0004708]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular [GO:0005622]; nucleus [GO:0005634]	GO:0005524; GO:0038095; GO:0007254; GO:0008545; GO:0004708; GO:0002755; GO:0002756; GO:0035666; GO:0007257; GO:0006915; GO:0072709; GO:0005737; GO:0005829; GO:0019899; GO:0045087; GO:0005622; GO:0000287; GO:0005634; GO:0043525; GO:0019901; GO:0019903; GO:0004674; GO:0004713; GO:0009411; GO:0009408; GO:0006970; GO:0034612; GO:0007165; GO:0051403; GO:0034166; GO:0034134; GO:0034138; GO:0034142; GO:0034146; GO:0034162; GO:0038123; GO:0038124; GO:0002224	SUBCELLULAR LOCATION: Nucleus. Cytoplasm {ECO:0000250}.	3D-structure; ATP-binding; Acetylation; Alternative splicing; Apoptosis; Coiled coil; Complete proteome; Cytoplasm; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Stress response; Transferase; Tyrosine-protein kinase	Active site (1); Alternative sequence (3); Beta strand (11); Binding site (1); Chain (1); Coiled coil (1); Domain (1); Erroneous termination (1); Frameshift (1); Helix (12); Initiator methionine (1); Modified residue (3); Natural variant (6); Nucleotide binding (1); Region (2); Sequence conflict (6); Site (2); Turn (5)
CRNL1_HUMAN	Q9BZJ0	CRNL1_HUMAN	reviewed	Crooked neck-like protein 1 (Crooked neck homolog) (hCrn)	CRNKL1 CRN CGI-201 MSTP021	Homo sapiens (Human)	848	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; spliceosomal complex [GO:0005681]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; activation of mitophagy in response to mitochondrial depolarization [GO:0098779]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of defense response to virus by host [GO:0002230]; spliceosomal complex assembly [GO:0000245]	activation of mitophagy in response to mitochondrial depolarization [GO:0098779]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of defense response to virus by host [GO:0002230]; spliceosomal complex assembly [GO:0000245]	poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; spliceosomal complex [GO:0005681]	GO:0003723; GO:0098779; GO:0071013; GO:0005737; GO:0000398; GO:0016607; GO:0044822; GO:0002230; GO:0005681; GO:0000245	SUBCELLULAR LOCATION: Nucleus speckle. Cytoplasm. Note=Colocalizes with core spliceosomal snRNP proteins. Also diffusely expressed in cytoplasm.	Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Polymorphism; Reference proteome; Repeat; Spliceosome; mRNA processing; mRNA splicing	Alternative sequence (5); Chain (1); Compositional bias (1); Erroneous initiation (2); Natural variant (5); Region (1); Repeat (17); Sequence conflict (4)
E7EMN6_HUMAN	E7EMN6	E7EMN6_HUMAN	unreviewed	Protein phosphatase inhibitor 2 (Fragment)	PPP1R2	Homo sapiens (Human)	170	protein phosphatase inhibitor activity [GO:0004864]; regulation of phosphoprotein phosphatase activity [GO:0043666]; regulation of signal transduction [GO:0009966]	regulation of phosphoprotein phosphatase activity [GO:0043666]; regulation of signal transduction [GO:0009966]	protein phosphatase inhibitor activity [GO:0004864]		GO:0004864; GO:0043666; GO:0009966		Complete proteome; Proteomics identification; Reference proteome	Non-terminal residue (1)
TAGAP_HUMAN	Q8N103	TAGAP_HUMAN	reviewed	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein)	TAGAP TAGAP1 FKSG15	Homo sapiens (Human)	731	cytosol [GO:0005829]; guanyl-nucleotide exchange factor activity [GO:0005085]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]	regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]	guanyl-nucleotide exchange factor activity [GO:0005085]	cytosol [GO:0005829]	GO:0005829; GO:0005085; GO:0051056; GO:0007264		Alternative splicing; Complete proteome; Guanine-nucleotide releasing factor; Phosphoprotein; Polymorphism; Reference proteome	Alternative sequence (5); Chain (1); Domain (1); Modified residue (1); Natural variant (1)
HIF1N_HUMAN	Q9NWT6	HIF1N_HUMAN	reviewed	Hypoxia-inducible factor 1-alpha inhibitor (EC 1.14.11.30) (EC 1.14.11.n4) (Factor inhibiting HIF-1) (FIH-1) (Hypoxia-inducible factor asparagine hydroxylase)	HIF1AN FIH1	Homo sapiens (Human)	349	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; ankyrin repeat binding [GO:0071532]; carboxylic acid binding [GO:0031406]; cofactor binding [GO:0048037]; iron ion binding [GO:0005506]; NF-kappaB binding [GO:0051059]; Notch binding [GO:0005112]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [GO:0016706]; oxygen sensor activity [GO:0019826]; peptidyl-asparagine 3-dioxygenase activity [GO:0036140]; peptidyl-histidine dioxygenase activity [GO:0036139]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]; cellular response to hypoxia [GO:0071456]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061428]; oxidation-reduction process [GO:0055114]; peptidyl-asparagine hydroxylation [GO:0042265]; peptidyl-aspartic acid hydroxylation [GO:0042264]; peptidyl-histidine hydroxylation [GO:0036138]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of vasculogenesis [GO:2001214]; regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061418]; transcription, DNA-templated [GO:0006351]	cellular response to hypoxia [GO:0071456]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061428]; oxidation-reduction process [GO:0055114]; peptidyl-asparagine hydroxylation [GO:0042265]; peptidyl-aspartic acid hydroxylation [GO:0042264]; peptidyl-histidine hydroxylation [GO:0036138]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of vasculogenesis [GO:2001214]; regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061418]; transcription, DNA-templated [GO:0006351]	ankyrin repeat binding [GO:0071532]; carboxylic acid binding [GO:0031406]; cofactor binding [GO:0048037]; iron ion binding [GO:0005506]; NF-kappaB binding [GO:0051059]; Notch binding [GO:0005112]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [GO:0016706]; oxygen sensor activity [GO:0019826]; peptidyl-asparagine 3-dioxygenase activity [GO:0036140]; peptidyl-histidine dioxygenase activity [GO:0036139]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]	GO:0051059; GO:0005112; GO:0071532; GO:0031406; GO:0071456; GO:0048037; GO:0005737; GO:0005829; GO:0005506; GO:0045746; GO:0061428; GO:0005654; GO:0055114; GO:0016706; GO:0019826; GO:0036140; GO:0042265; GO:0042264; GO:0036139; GO:0036138; GO:0048471; GO:0045663; GO:2001214; GO:0042803; GO:0061418; GO:0006351; GO:0008270	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Mainly cytoplasmic localization, but interaction with NOTCH1 results in nuclear localization and interaction with ABPA3 results in perinuclear localization in macrophages.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Dioxygenase; Iron; Metal-binding; Nucleus; Oxidoreductase; Polymorphism; Reference proteome; Transcription; Transcription regulation	Beta strand (21); Binding site (8); Chain (1); Domain (1); Helix (15); Initiator methionine (1); Mass spectrometry (1); Metal binding (3); Modified residue (1); Mutagenesis (8); Natural variant (1); Region (4); Sequence conflict (3); Site (1); Turn (5)
PSMG1_HUMAN	O95456	PSMG1_HUMAN	reviewed	Proteasome assembly chaperone 1 (PAC-1) (Chromosome 21 leucine-rich protein) (C21-LRP) (Down syndrome critical region protein 2)	PSMG1 C21LRP DSCR2 PAC1	Homo sapiens (Human)	288	cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; cerebellar granule cell precursor proliferation [GO:0021930]; proteasome assembly [GO:0043248]; proteasome core complex assembly [GO:0080129]	cerebellar granule cell precursor proliferation [GO:0021930]; proteasome assembly [GO:0043248]; proteasome core complex assembly [GO:0080129]		cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]	GO:0021930; GO:0005737; GO:0005783; GO:0005634; GO:0043248; GO:0080129	SUBCELLULAR LOCATION: Cytoplasm. Endoplasmic reticulum.	Acetylation; Alternative splicing; Chaperone; Complete proteome; Cytoplasm; Endoplasmic reticulum; Polymorphism; Reference proteome	Alternative sequence (1); Chain (1); Initiator methionine (1); Modified residue (2); Natural variant (1); Sequence conflict (1)
F5H4R4_HUMAN	F5H4R4	F5H4R4_HUMAN	unreviewed	mRNA-decapping enzyme 1B	DCP1B	Homo sapiens (Human)	119	cytoplasmic mRNA processing body [GO:0000932]; enzyme regulator activity [GO:0030234]; mRNA binding [GO:0003729]; deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; deadenylation-independent decapping of nuclear-transcribed mRNA [GO:0031087]; regulation of catalytic activity [GO:0050790]	deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; deadenylation-independent decapping of nuclear-transcribed mRNA [GO:0031087]; regulation of catalytic activity [GO:0050790]	enzyme regulator activity [GO:0030234]; mRNA binding [GO:0003729]	cytoplasmic mRNA processing body [GO:0000932]	GO:0000932; GO:0000290; GO:0031087; GO:0030234; GO:0003729; GO:0050790		Complete proteome; Proteomics identification; Reference proteome	
B4DY08_HUMAN	B4DY08	B4DY08_HUMAN	unreviewed	Heterogeneous nuclear ribonucleoproteins C1/C2 (cDNA FLJ53542, highly similar to Heterogeneous nuclear ribonucleoproteins C)	HNRNPC	Homo sapiens (Human)	288	ribonucleoprotein complex [GO:0030529]; viral nucleocapsid [GO:0019013]; nucleic acid binding [GO:0003676]; nucleotide binding [GO:0000166]		nucleic acid binding [GO:0003676]; nucleotide binding [GO:0000166]	ribonucleoprotein complex [GO:0030529]; viral nucleocapsid [GO:0019013]	GO:0003676; GO:0000166; GO:0030529; GO:0019013		Complete proteome; Proteomics identification; Reference proteome; Ribonucleoprotein; Viral nucleoprotein; Virion	
G3V2Q1_HUMAN	G3V2Q1	G3V2Q1_HUMAN	unreviewed	Heterogeneous nuclear ribonucleoproteins C1/C2	HNRNPC	Homo sapiens (Human)	305	nucleoplasm [GO:0005654]; nucleic acid binding [GO:0003676]; nucleotide binding [GO:0000166]		nucleic acid binding [GO:0003676]; nucleotide binding [GO:0000166]	nucleoplasm [GO:0005654]	GO:0003676; GO:0005654; GO:0000166		Complete proteome; Proteomics identification; Reference proteome	
EI2BD_HUMAN	Q9UI10	EI2BD_HUMAN	reviewed	Translation initiation factor eIF-2B subunit delta (eIF-2B GDP-GTP exchange factor subunit delta)	EIF2B4 EIF2BD	Homo sapiens (Human)	523	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2B complex [GO:0005851]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369]; cellular protein metabolic process [GO:0044267]; cellular response to stimulus [GO:0051716]; gene expression [GO:0010467]; myelination [GO:0042552]; negative regulation of translational initiation [GO:0045947]; negative regulation of translational initiation in response to stress [GO:0032057]; oligodendrocyte development [GO:0014003]; ovarian follicle development [GO:0001541]; positive regulation of GTPase activity [GO:0043547]; regulation of translation [GO:0006417]; response to glucose [GO:0009749]; response to heat [GO:0009408]; response to peptide hormone [GO:0043434]; translation [GO:0006412]; translational initiation [GO:0006413]	cellular protein metabolic process [GO:0044267]; cellular response to stimulus [GO:0051716]; gene expression [GO:0010467]; myelination [GO:0042552]; negative regulation of translational initiation [GO:0045947]; negative regulation of translational initiation in response to stress [GO:0032057]; oligodendrocyte development [GO:0014003]; ovarian follicle development [GO:0001541]; positive regulation of GTPase activity [GO:0043547]; regulation of translation [GO:0006417]; response to glucose [GO:0009749]; response to heat [GO:0009408]; response to peptide hormone [GO:0043434]; translation [GO:0006412]; translational initiation [GO:0006413]	translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2B complex [GO:0005851]	GO:0044267; GO:0051716; GO:0005737; GO:0005829; GO:0005851; GO:0010467; GO:0042552; GO:0045947; GO:0032057; GO:0014003; GO:0001541; GO:0043547; GO:0006417; GO:0009749; GO:0009408; GO:0043434; GO:0006412; GO:0003743; GO:0031369; GO:0006413		Acetylation; Alternative splicing; Complete proteome; Disease mutation; Initiation factor; Leukodystrophy; Phosphoprotein; Polymorphism; Protein biosynthesis; Reference proteome	Alternative sequence (2); Chain (1); Erroneous gene model prediction (1); Initiator methionine (1); Modified residue (2); Natural variant (9); Sequence conflict (6)
PDD2L_HUMAN	Q9BRP1	PDD2L_HUMAN	reviewed	Programmed cell death protein 2-like	PDCD2L	Homo sapiens (Human)	358	cytoplasm [GO:0005737]; membrane [GO:0016020]; cell cycle [GO:0007049]	cell cycle [GO:0007049]		cytoplasm [GO:0005737]; membrane [GO:0016020]	GO:0007049; GO:0005737; GO:0016020		Acetylation; Cell cycle; Complete proteome; Reference proteome	Chain (1); Initiator methionine (1); Modified residue (1)
SNX5_HUMAN	Q9Y5X3	SNX5_HUMAN	reviewed	Sorting nexin-5	SNX5	Homo sapiens (Human)	404	cytoplasmic vesicle membrane [GO:0030659]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; extrinsic component of endosome membrane [GO:0031313]; macropinocytic cup [GO:0070685]; phagocytic cup [GO:0001891]; retromer complex [GO:0030904]; ruffle [GO:0001726]; tubular endosome [GO:0097422]; dynactin binding [GO:0034452]; phosphatidylinositol binding [GO:0035091]; intracellular protein transport [GO:0006886]; pinocytosis [GO:0006907]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle organization [GO:0016050]	intracellular protein transport [GO:0006886]; pinocytosis [GO:0006907]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle organization [GO:0016050]	dynactin binding [GO:0034452]; phosphatidylinositol binding [GO:0035091]	cytoplasmic vesicle membrane [GO:0030659]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; extrinsic component of endosome membrane [GO:0031313]; macropinocytic cup [GO:0070685]; phagocytic cup [GO:0001891]; retromer complex [GO:0030904]; ruffle [GO:0001726]; tubular endosome [GO:0097422]	GO:0030659; GO:0034452; GO:0031901; GO:0005768; GO:0031234; GO:0031313; GO:0006886; GO:0070685; GO:0001891; GO:0035091; GO:0006907; GO:0042147; GO:0030904; GO:0001726; GO:0097422; GO:0016050	SUBCELLULAR LOCATION: Endosome {ECO:0000269|PubMed:11485546}. Early endosome {ECO:0000269|PubMed:17148574, ECO:0000269|PubMed:24610942}. Early endosome membrane {ECO:0000269|PubMed:15561769}; Peripheral membrane protein; Cytoplasmic side. Cell membrane {ECO:0000269|PubMed:15561769}; Peripheral membrane protein; Cytoplasmic side {ECO:0000269|PubMed:18854019}. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Cell projection, phagocytic cup. Cell projection, ruffle. Note=Recruited to the plasma membrane after EGF stimulation, which leads to increased levels of phosphatidylinositol 3,4-bisphosphate (PdtIns(3,4)P2) (PubMed:15561769). Detected on macropinosomes (PubMed:16968745, PubMed:21048941). Targeted to membrane ruffles in response to EGFR stimulation. {ECO:0000269|PubMed:15561769, ECO:0000269|PubMed:16968745, ECO:0000269|PubMed:21048941}.	3D-structure; Acetylation; Alternative splicing; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Endocytosis; Endosome; Lipid-binding; Membrane; Protein transport; Reference proteome; Transport	Alternative sequence (2); Chain (1); Domain (2); Initiator methionine (1); Modified residue (2); Mutagenesis (8); Region (5); Sequence conflict (1)
PROF1_HUMAN	P07737	PROF1_HUMAN	reviewed	Profilin-1 (Epididymis tissue protein Li 184a) (Profilin I)	PFN1	Homo sapiens (Human)	140	blood microparticle [GO:0072562]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleus [GO:0005634]; synapse [GO:0045202]; actin binding [GO:0003779]; actin monomer binding [GO:0003785]; adenyl-nucleotide exchange factor activity [GO:0000774]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; poly(A) RNA binding [GO:0044822]; proline-rich region binding [GO:0070064]; actin cytoskeleton organization [GO:0030036]; blood coagulation [GO:0007596]; cellular response to growth factor stimulus [GO:0071363]; negative regulation of actin filament bundle assembly [GO:0032232]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of stress fiber assembly [GO:0051497]; neural tube closure [GO:0001843]; platelet activation [GO:0030168]; platelet degranulation [GO:0002576]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of ATPase activity [GO:0032781]; positive regulation of DNA metabolic process [GO:0051054]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of ruffle assembly [GO:1900029]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of viral transcription [GO:0050434]; protein stabilization [GO:0050821]	actin cytoskeleton organization [GO:0030036]; blood coagulation [GO:0007596]; cellular response to growth factor stimulus [GO:0071363]; negative regulation of actin filament bundle assembly [GO:0032232]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of stress fiber assembly [GO:0051497]; neural tube closure [GO:0001843]; platelet activation [GO:0030168]; platelet degranulation [GO:0002576]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of ATPase activity [GO:0032781]; positive regulation of DNA metabolic process [GO:0051054]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of ruffle assembly [GO:1900029]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of viral transcription [GO:0050434]; protein stabilization [GO:0050821]	actin binding [GO:0003779]; actin monomer binding [GO:0003785]; adenyl-nucleotide exchange factor activity [GO:0000774]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; poly(A) RNA binding [GO:0044822]; proline-rich region binding [GO:0070064]	blood microparticle [GO:0072562]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleus [GO:0005634]; synapse [GO:0045202]	GO:0003779; GO:0030036; GO:0003785; GO:0000774; GO:0007596; GO:0072562; GO:0005938; GO:0071363; GO:0005737; GO:0005856; GO:0005829; GO:0070062; GO:0005925; GO:0016020; GO:0032232; GO:0030837; GO:0051497; GO:0001843; GO:0043005; GO:0005634; GO:0005546; GO:0030168; GO:0002576; GO:0044822; GO:0032781; GO:0051054; GO:0030838; GO:0010634; GO:1900029; GO:0051496; GO:0045944; GO:0050434; GO:0070064; GO:0050821; GO:0045202	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.	3D-structure; Acetylation; Actin-binding; Amyotrophic lateral sclerosis; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Disease mutation; Isopeptide bond; Neurodegeneration; Phosphoprotein; Reference proteome; Ubl conjugation	Beta strand (10); Chain (1); Cross-link (1); Helix (5); Initiator methionine (1); Modified residue (6); Natural variant (4); Turn (1)
Q5TBG5_HUMAN	Q5TBG5	Q5TBG5_HUMAN	unreviewed	Proteasome subunit beta type (EC 3.4.25.1) (Fragment)	PSMB7	Homo sapiens (Human)	210	cytoplasm [GO:0005737]; nucleus [GO:0005634]; proteasome core complex [GO:0005839]; endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; proteasome core complex [GO:0005839]	GO:0005737; GO:0004175; GO:0005634; GO:0010499; GO:0005839; GO:0043161; GO:0004298	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU000694}. Nucleus {ECO:0000256|RuleBase:RU000694}.	Complete proteome; Hydrolase; Protease; Proteasome; Proteomics identification; Reference proteome; Threonine protease	Non-terminal residue (1)
REQU_HUMAN	Q92785	REQU_HUMAN	reviewed	Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem)	DPF2 BAF45D REQ UBID4	Homo sapiens (Human)	391	centrosome [GO:0005813]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nuclear chromatin [GO:0000790]; nucleoplasm [GO:0005654]; RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]	apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]	RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978]; zinc ion binding [GO:0008270]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nuclear chromatin [GO:0000790]; nucleoplasm [GO:0005654]	GO:0000978; GO:0006915; GO:0097190; GO:0005813; GO:0005737; GO:0043231; GO:0000790; GO:0005654; GO:0006355; GO:0006351; GO:0008270	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=30% nuclear. 70% cytoplasmic.	3D-structure; Acetylation; Alternative splicing; Apoptosis; Complete proteome; Cytoplasm; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger	Alternative sequence (1); Beta strand (1); Chain (1); Helix (1); Initiator methionine (1); Modified residue (6); Turn (2); Zinc finger (3)
PGAM1_HUMAN	P18669	PGAM1_HUMAN	reviewed	Phosphoglycerate mutase 1 (EC 3.1.3.13) (EC 5.4.2.11) (EC 5.4.2.4) (BPG-dependent PGAM 1) (Phosphoglycerate mutase isozyme B) (PGAM-B)	PGAM1 PGAMA CDABP0006	Homo sapiens (Human)	254	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; bisphosphoglycerate 2-phosphatase activity [GO:0004083]; bisphosphoglycerate mutase activity [GO:0004082]; phosphoglycerate mutase activity [GO:0004619]; protein kinase binding [GO:0019901]; canonical glycolysis [GO:0061621]; carbohydrate metabolic process [GO:0005975]; gluconeogenesis [GO:0006094]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; regulation of glycolytic process [GO:0006110]; regulation of pentose-phosphate shunt [GO:0043456]; respiratory burst [GO:0045730]; small molecule metabolic process [GO:0044281]	canonical glycolysis [GO:0061621]; carbohydrate metabolic process [GO:0005975]; gluconeogenesis [GO:0006094]; glucose metabolic process [GO:0006006]; glycolytic process [GO:0006096]; regulation of glycolytic process [GO:0006110]; regulation of pentose-phosphate shunt [GO:0043456]; respiratory burst [GO:0045730]; small molecule metabolic process [GO:0044281]	bisphosphoglycerate 2-phosphatase activity [GO:0004083]; bisphosphoglycerate mutase activity [GO:0004082]; phosphoglycerate mutase activity [GO:0004619]; protein kinase binding [GO:0019901]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]	GO:0004083; GO:0004082; GO:0061621; GO:0005975; GO:0005737; GO:0005829; GO:0070062; GO:0006094; GO:0006006; GO:0006096; GO:0016020; GO:0004619; GO:0019901; GO:0006110; GO:0043456; GO:0045730; GO:0044281		3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Glycolysis; Hydrolase; Isomerase; Phosphoprotein; Reference proteome	Active site (2); Beta strand (7); Binding site (2); Chain (1); Compositional bias (1); Helix (13); Initiator methionine (1); Modified residue (9); Region (5); Site (1); Turn (2)
LEG1_HUMAN	P09382	LEG1_HUMAN	reviewed	Galectin-1 (Gal-1) (14 kDa laminin-binding protein) (HLBP14) (14 kDa lectin) (Beta-galactoside-binding lectin L-14-I) (Galaptin) (HBL) (HPL) (Lactose-binding lectin 1) (Lectin galactoside-binding soluble 1) (Putative MAPK-activating protein PM12) (S-Lac lectin 1)	LGALS1	Homo sapiens (Human)	135	cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; intracellular [GO:0005622]; nucleus [GO:0005634]; proteinaceous extracellular matrix [GO:0005578]; galactoside binding [GO:0016936]; lactose binding [GO:0030395]; poly(A) RNA binding [GO:0044822]; signal transducer activity [GO:0004871]; apoptotic process [GO:0006915]; cellular response to glucose stimulus [GO:0071333]; cellular response to organic cyclic compound [GO:0071407]; multicellular organismal response to stress [GO:0033555]; myoblast differentiation [GO:0045445]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of neuron projection development [GO:0010977]; plasma cell differentiation [GO:0002317]; positive regulation of erythrocyte aggregation [GO:0034120]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; regulation of apoptotic process [GO:0042981]; response to axon injury [GO:0048678]; response to drug [GO:0042493]; signal transduction [GO:0007165]; T cell costimulation [GO:0031295]	apoptotic process [GO:0006915]; cellular response to glucose stimulus [GO:0071333]; cellular response to organic cyclic compound [GO:0071407]; multicellular organismal response to stress [GO:0033555]; myoblast differentiation [GO:0045445]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of neuron projection development [GO:0010977]; plasma cell differentiation [GO:0002317]; positive regulation of erythrocyte aggregation [GO:0034120]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; regulation of apoptotic process [GO:0042981]; response to axon injury [GO:0048678]; response to drug [GO:0042493]; signal transduction [GO:0007165]; T cell costimulation [GO:0031295]	galactoside binding [GO:0016936]; lactose binding [GO:0030395]; poly(A) RNA binding [GO:0044822]; signal transducer activity [GO:0004871]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; intracellular [GO:0005622]; nucleus [GO:0005634]; proteinaceous extracellular matrix [GO:0005578]	GO:0031295; GO:0006915; GO:0009986; GO:0071333; GO:0071407; GO:0005737; GO:0070062; GO:0005615; GO:0016936; GO:0005622; GO:0030395; GO:0033555; GO:0045445; GO:0010812; GO:0010977; GO:0005634; GO:0002317; GO:0044822; GO:0043123; GO:0034120; GO:0005578; GO:0042981; GO:0048678; GO:0042493; GO:0004871; GO:0007165	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:14617626}.	3D-structure; Acetylation; Apoptosis; Complete proteome; Direct protein sequencing; Extracellular matrix; Lectin; Reference proteome; Secreted	Beta strand (10); Binding site (2); Chain (1); Domain (1); Helix (1); Initiator methionine (1); Modified residue (6); Region (2)
QOR_HUMAN	Q08257	QOR_HUMAN	reviewed	Quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) (Zeta-crystallin)	CRYZ	Homo sapiens (Human)	329	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; mRNA 3'-UTR binding [GO:0003730]; NADPH binding [GO:0070402]; NADPH:quinone reductase activity [GO:0003960]; zinc ion binding [GO:0008270]; protein homotetramerization [GO:0051289]; visual perception [GO:0007601]; xenobiotic catabolic process [GO:0042178]	protein homotetramerization [GO:0051289]; visual perception [GO:0007601]; xenobiotic catabolic process [GO:0042178]	mRNA 3'-UTR binding [GO:0003730]; NADPH:quinone reductase activity [GO:0003960]; NADPH binding [GO:0070402]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]	GO:0005794; GO:0070402; GO:0003960; GO:0005737; GO:0005829; GO:0070062; GO:0043231; GO:0003730; GO:0051289; GO:0007601; GO:0042178; GO:0008270	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20103721}.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; NADP; Oxidoreductase; Phosphoprotein; Polymorphism; RNA-binding; Reference proteome	Alternative sequence (3); Beta strand (17); Binding site (4); Chain (1); Helix (14); Initiator methionine (1); Modified residue (4); Natural variant (3); Nucleotide binding (3); Sequence conflict (1); Turn (2)
DCPS_HUMAN	Q96C86	DCPS_HUMAN	reviewed	m7GpppX diphosphatase (EC 3.6.1.59) (DCS-1) (Decapping scavenger enzyme) (Hint-related 7meGMP-directed hydrolase) (Histidine triad nucleotide-binding protein 5) (Histidine triad protein member 5) (HINT-5) (Scavenger mRNA-decapping enzyme DcpS)	DCPS DCS1 HINT5 HSPC015	Homo sapiens (Human)	337	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; m7G(5')pppN diphosphatase activity [GO:0050072]; RNA 7-methylguanosine cap binding [GO:0000340]; cellular response to menadione [GO:0036245]; deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [GO:0043928]; gene expression [GO:0010467]; mRNA cis splicing, via spliceosome [GO:0045292]; negative regulation of programmed cell death [GO:0043069]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]	cellular response to menadione [GO:0036245]; deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [GO:0043928]; gene expression [GO:0010467]; mRNA cis splicing, via spliceosome [GO:0045292]; negative regulation of programmed cell death [GO:0043069]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]	m7G(5')pppN diphosphatase activity [GO:0050072]; RNA 7-methylguanosine cap binding [GO:0000340]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000340; GO:0036245; GO:0005737; GO:0005829; GO:0000290; GO:0043928; GO:0010467; GO:0050072; GO:0045292; GO:0005739; GO:0043069; GO:0000288; GO:0005654; GO:0005634	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Predominantly localized in the nucleus. Nucleocytoplasmic shuttling protein that can transiently enter the cytoplasm in mammalian cells in a XPO1/CRM1-dependent manner.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Nucleus; Polymorphism; Reference proteome; mRNA processing; mRNA splicing	Active site (1); Beta strand (17); Binding site (4); Chain (1); Helix (15); Initiator methionine (1); Modified residue (3); Motif (3); Mutagenesis (32); Natural variant (1); Region (1); Sequence conflict (1); Turn (3)
DC1I2_HUMAN	Q13409	DC1I2_HUMAN	reviewed	Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2)	DYNC1I2 DNCI2 DNCIC2	Homo sapiens (Human)	638	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; cytosol [GO:0005829]; microtubule [GO:0005874]; vesicle [GO:0031982]; microtubule motor activity [GO:0003777]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; G2/M transition of mitotic cell cycle [GO:0000086]; metabolic process [GO:0008152]; microtubule-based movement [GO:0007018]; mitotic cell cycle [GO:0000278]; organelle organization [GO:0006996]; transport [GO:0006810]; viral process [GO:0016032]	antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; G2/M transition of mitotic cell cycle [GO:0000086]; metabolic process [GO:0008152]; microtubule-based movement [GO:0007018]; mitotic cell cycle [GO:0000278]; organelle organization [GO:0006996]; transport [GO:0006810]; viral process [GO:0016032]	microtubule motor activity [GO:0003777]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; cytosol [GO:0005829]; microtubule [GO:0005874]; vesicle [GO:0031982]	GO:0000086; GO:0019886; GO:0005813; GO:0005737; GO:0005868; GO:0005829; GO:0008152; GO:0005874; GO:0003777; GO:0007018; GO:0000278; GO:0006996; GO:0006810; GO:0031982; GO:0016032	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.	Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Dynein; Host-virus interaction; Microtubule; Motor protein; Phosphoprotein; Reference proteome; Repeat; Transport; WD repeat	Alternative sequence (4); Chain (1); Initiator methionine (1); Modified residue (5); Repeat (7); Sequence caution (1); Sequence conflict (3)
MOES_HUMAN	P26038	MOES_HUMAN	reviewed	Moesin (Membrane-organizing extension spike protein)	MSN	Homo sapiens (Human)	577	apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; blood microparticle [GO:0072562]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; extrinsic component of membrane [GO:0019898]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; microvillus [GO:0005902]; microvillus membrane [GO:0031528]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; uropod [GO:0001931]; vesicle [GO:0031982]; cell adhesion molecule binding [GO:0050839]; double-stranded RNA binding [GO:0003725]; protein kinase binding [GO:0019901]; receptor binding [GO:0005102]; structural constituent of cytoskeleton [GO:0005200]; establishment of endothelial barrier [GO:0061028]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte migration [GO:0050900]; membrane to membrane docking [GO:0022614]; movement of cell or subcellular component [GO:0006928]; positive regulation of cellular protein catabolic process [GO:1903364]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of gene expression [GO:0010628]; positive regulation of protein localization to early endosome [GO:1902966]; regulation of lymphocyte migration [GO:2000401]; regulation of organelle assembly [GO:1902115]	establishment of endothelial barrier [GO:0061028]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte migration [GO:0050900]; membrane to membrane docking [GO:0022614]; movement of cell or subcellular component [GO:0006928]; positive regulation of cellular protein catabolic process [GO:1903364]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of gene expression [GO:0010628]; positive regulation of protein localization to early endosome [GO:1902966]; regulation of lymphocyte migration [GO:2000401]; regulation of organelle assembly [GO:1902115]	cell adhesion molecule binding [GO:0050839]; double-stranded RNA binding [GO:0003725]; protein kinase binding [GO:0019901]; receptor binding [GO:0005102]; structural constituent of cytoskeleton [GO:0005200]	apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; blood microparticle [GO:0072562]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; extrinsic component of membrane [GO:0019898]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; microvillus [GO:0005902]; microvillus membrane [GO:0031528]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; uropod [GO:0001931]; vesicle [GO:0031982]	GO:0045177; GO:0016324; GO:0016323; GO:0072562; GO:0050839; GO:0071944; GO:0005737; GO:0005856; GO:0003725; GO:0061028; GO:0070062; GO:0005615; GO:0019898; GO:0030175; GO:0005925; GO:0007159; GO:0050900; GO:0022614; GO:0005902; GO:0031528; GO:0006928; GO:0005634; GO:0005886; GO:1903364; GO:2000643; GO:0010628; GO:1902966; GO:0019901; GO:0005102; GO:2000401; GO:1902115; GO:0005200; GO:0001931; GO:0031982	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Apical cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell projection, microvillus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Phosphorylated form is enriched in microvilli-like structures at apical membrane (By similarity). Increased cell membrane localization of both phosphorylated and non-phosphorylated forms seen after thrombin treatment. {ECO:0000250, ECO:0000269|PubMed:18586956}.	3D-structure; Acetylation; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Membrane; Phosphoprotein; Reference proteome; S-nitrosylation	Beta strand (14); Chain (1); Domain (1); Helix (18); Initiator methionine (1); Modified residue (9); Motif (1); Mutagenesis (5); Turn (4)
SND1_HUMAN	Q7KZF4	SND1_HUMAN	reviewed	Staphylococcal nuclease domain-containing protein 1 (100 kDa coactivator) (EBNA2 coactivator p100) (Tudor domain-containing protein 11) (p100 co-activator)	SND1 TDRD11	Homo sapiens (Human)	910	cytoplasm [GO:0005737]; dense body [GO:0097433]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; RISC complex [GO:0016442]; nuclease activity [GO:0004518]; poly(A) RNA binding [GO:0044822]; transcription cofactor activity [GO:0003712]; osteoblast differentiation [GO:0001649]; posttranscriptional gene silencing by RNA [GO:0035194]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]; viral process [GO:0016032]	osteoblast differentiation [GO:0001649]; posttranscriptional gene silencing by RNA [GO:0035194]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]; viral process [GO:0016032]	nuclease activity [GO:0004518]; poly(A) RNA binding [GO:0044822]; transcription cofactor activity [GO:0003712]	cytoplasm [GO:0005737]; dense body [GO:0097433]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; RISC complex [GO:0016442]	GO:0016442; GO:0005737; GO:0097433; GO:0070062; GO:0042470; GO:0016020; GO:0005739; GO:0004518; GO:0005634; GO:0001649; GO:0044822; GO:0035194; GO:0006355; GO:0003712; GO:0006351; GO:0016032	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17081065}. Nucleus {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=In IL-4 stimulated cells colocalizes with STAT6 in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Host-virus interaction; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation	Beta strand (41); Chain (1); Domain (5); Frameshift (1); Helix (33); Initiator methionine (1); Modified residue (7); Motif (2); Sequence conflict (2); Turn (11)
RS2_HUMAN	P15880	RS2_HUMAN	reviewed	40S ribosomal protein S2 (40S ribosomal protein S4) (Protein LLRep3)	RPS2 RPS4	Homo sapiens (Human)	293	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; enzyme binding [GO:0019899]; fibroblast growth factor binding [GO:0017134]; mRNA binding [GO:0003729]; poly(A) RNA binding [GO:0044822]; structural constituent of ribosome [GO:0003735]; cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of transferase activity [GO:0051347]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of transferase activity [GO:0051347]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	enzyme binding [GO:0019899]; fibroblast growth factor binding [GO:0017134]; mRNA binding [GO:0003729]; poly(A) RNA binding [GO:0044822]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0006614; GO:0044267; GO:0005737; GO:0005829; GO:0022627; GO:0019899; GO:0070062; GO:0017134; GO:0005925; GO:0010467; GO:0003729; GO:0016020; GO:0000184; GO:0005654; GO:0005634; GO:0044822; GO:0051347; GO:0003735; GO:0006412; GO:0006414; GO:0006413; GO:0006415; GO:0019058; GO:0016032; GO:0019083		3D-structure; Acetylation; Citrullination; Complete proteome; Direct protein sequencing; Methylation; Phosphoprotein; Reference proteome; Repeat; Ribonucleoprotein; Ribosomal protein	Chain (1); Compositional bias (1); Domain (1); Frameshift (1); Initiator methionine (1); Modified residue (5)
I3L397_HUMAN	I3L397	I3L397_HUMAN	unreviewed	Eukaryotic translation initiation factor 5A (eIF-5A) (Fragment)	EIF5A	Homo sapiens (Human)	147	ribosome binding [GO:0043022]; translation elongation factor activity [GO:0003746]; positive regulation of translational elongation [GO:0045901]; positive regulation of translational termination [GO:0045905]; translational frameshifting [GO:0006452]	positive regulation of translational elongation [GO:0045901]; positive regulation of translational termination [GO:0045905]; translational frameshifting [GO:0006452]	ribosome binding [GO:0043022]; translation elongation factor activity [GO:0003746]		GO:0045901; GO:0045905; GO:0043022; GO:0003746; GO:0006452		Complete proteome; Hypusine; Protein biosynthesis; Proteomics identification; Reference proteome	Non-terminal residue (1)
ERF1_HUMAN	P62495	ERF1_HUMAN	reviewed	Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) (Protein Cl1) (TB3-1)	ETF1 ERF1 RF1 SUP45L1	Homo sapiens (Human)	437	cytoplasm [GO:0005737]; cytosol [GO:0005829]; translation release factor complex [GO:0018444]; poly(A) RNA binding [GO:0044822]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation release factor activity [GO:0003747]; translation release factor activity, codon specific [GO:0016149]; translation termination factor activity [GO:0008079]; cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; protein methylation [GO:0006479]; regulation of translational termination [GO:0006449]; translation [GO:0006412]; translational termination [GO:0006415]	cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; protein methylation [GO:0006479]; regulation of translational termination [GO:0006449]; translation [GO:0006412]; translational termination [GO:0006415]	poly(A) RNA binding [GO:0044822]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; translation release factor activity [GO:0003747]; translation release factor activity, codon specific [GO:0016149]; translation termination factor activity [GO:0008079]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; translation release factor complex [GO:0018444]	GO:0003723; GO:0044267; GO:0005737; GO:0005829; GO:0010467; GO:0000184; GO:0044822; GO:0006479; GO:0006449; GO:0043022; GO:0006412; GO:0003747; GO:0016149; GO:0018444; GO:0008079; GO:0006415	SUBCELLULAR LOCATION: Cytoplasm.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Nonsense-mediated mRNA decay; Protein biosynthesis; Reference proteome	Alternative sequence (1); Beta strand (28); Chain (1); Helix (15); Initiator methionine (1); Modified residue (1); Turn (11)
LSM3_HUMAN	P62310	LSM3_HUMAN	reviewed	U6 snRNA-associated Sm-like protein LSm3	LSM3 MDS017	Homo sapiens (Human)	102	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; nucleus [GO:0005634]; poly(A) RNA binding [GO:0044822]; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [GO:0043928]; gene expression [GO:0010467]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [GO:0043928]; gene expression [GO:0010467]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]	poly(A) RNA binding [GO:0044822]	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0071013; GO:0005829; GO:0043928; GO:0010467; GO:0006397; GO:0000398; GO:0000288; GO:0005634; GO:0044822	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.	Acetylation; Complete proteome; Direct protein sequencing; Nucleus; RNA-binding; Reference proteome; Ribonucleoprotein; Spliceosome; mRNA processing; mRNA splicing	Chain (1); Initiator methionine (1); Modified residue (1)
SNX27_HUMAN	Q96L92	SNX27_HUMAN	reviewed	Sorting nexin-27	SNX27 KIAA0488 My014	Homo sapiens (Human)	541	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; immunological synapse [GO:0001772]; nucleoplasm [GO:0005654]; phosphatidylinositol-3-phosphate binding [GO:0032266]; endosomal transport [GO:0016197]; endosome to lysosome transport [GO:0008333]; establishment of natural killer cell polarity [GO:0001770]; intracellular protein transport [GO:0006886]; retrograde transport, endosome to plasma membrane [GO:1990126]; signal transduction [GO:0007165]	endosomal transport [GO:0016197]; endosome to lysosome transport [GO:0008333]; establishment of natural killer cell polarity [GO:0001770]; intracellular protein transport [GO:0006886]; retrograde transport, endosome to plasma membrane [GO:1990126]; signal transduction [GO:0007165]	phosphatidylinositol-3-phosphate binding [GO:0032266]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; immunological synapse [GO:0001772]; nucleoplasm [GO:0005654]	GO:0005737; GO:0005829; GO:0005769; GO:0031901; GO:0016197; GO:0008333; GO:0001770; GO:0001772; GO:0006886; GO:0005654; GO:0032266; GO:1990126; GO:0007165	SUBCELLULAR LOCATION: Early endosome membrane; Peripheral membrane protein. Cytoplasm, cytosol. Note=Localizes to immunological synapse in T-cells. In T-cells, recruited from the cytosol to sorting endosomes by phosphoinositide-3-kinase products.	3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Endosome; Lipid-binding; Membrane; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport	Alternative sequence (4); Beta strand (3); Chain (1); Domain (3); Erroneous initiation (1); Helix (4); Modified residue (1); Mutagenesis (1); Natural variant (1); Region (3); Sequence conflict (1); Turn (1)
EF2K_HUMAN	O00418	EF2K_HUMAN	reviewed	Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase)	EEF2K	Homo sapiens (Human)	725	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; elongation factor-2 kinase activity [GO:0004686]; protein kinase activity [GO:0004672]; translation factor activity, RNA binding [GO:0008135]; insulin receptor signaling pathway [GO:0008286]; protein autophosphorylation [GO:0046777]; regulation of protein autophosphorylation [GO:0031952]; translational elongation [GO:0006414]	insulin receptor signaling pathway [GO:0008286]; protein autophosphorylation [GO:0046777]; regulation of protein autophosphorylation [GO:0031952]; translational elongation [GO:0006414]	ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; elongation factor-2 kinase activity [GO:0004686]; protein kinase activity [GO:0004672]; translation factor activity, RNA binding [GO:0008135]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0005524; GO:0005509; GO:0005516; GO:0005737; GO:0005829; GO:0004686; GO:0008286; GO:0046777; GO:0004672; GO:0031952; GO:0008135; GO:0006414		ATP-binding; Acetylation; Calcium; Calmodulin-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase	Chain (1); Domain (1); Initiator methionine (1); Modified residue (18); Mutagenesis (4); Natural variant (6); Nucleotide binding (1); Region (2)
IPO7_HUMAN	O95373	IPO7_HUMAN	reviewed	Importin-7 (Imp7) (Ran-binding protein 7) (RanBP7)	IPO7 RANBP7	Homo sapiens (Human)	1038	cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; GTPase regulator activity [GO:0030695]; Ran GTPase binding [GO:0008536]; transporter activity [GO:0005215]; innate immune response [GO:0045087]; protein import into nucleus [GO:0006606]; regulation of catalytic activity [GO:0050790]; signal transduction [GO:0007165]; viral process [GO:0016032]	innate immune response [GO:0045087]; protein import into nucleus [GO:0006606]; regulation of catalytic activity [GO:0050790]; signal transduction [GO:0007165]; viral process [GO:0016032]	GTPase regulator activity [GO:0030695]; Ran GTPase binding [GO:0008536]; transporter activity [GO:0005215]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]	GO:0030695; GO:0008536; GO:0005737; GO:0045087; GO:0016020; GO:0005643; GO:0005654; GO:0006606; GO:0050790; GO:0007165; GO:0005215; GO:0016032	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.	Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Host-virus interaction; Nucleus; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport	Chain (1); Compositional bias (1); Domain (1); Modified residue (4); Mutagenesis (1); Natural variant (1)
HINT1_HUMAN	P49773	HINT1_HUMAN	reviewed	Histidine triad nucleotide-binding protein 1 (EC 3.-.-.-) (Adenosine 5'-monophosphoramidase) (Protein kinase C inhibitor 1) (Protein kinase C-interacting protein 1) (PKCI-1)	HINT1 HINT PKCI1 PRKCNH1	Homo sapiens (Human)	126	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; histone deacetylase complex [GO:0000118]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; hydrolase activity [GO:0016787]; nucleotide binding [GO:0000166]; protein kinase C binding [GO:0005080]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; purine ribonucleotide catabolic process [GO:0009154]; regulation of transcription, DNA-templated [GO:0006355]; signal transduction [GO:0007165]; transcription, DNA-templated [GO:0006351]	intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; purine ribonucleotide catabolic process [GO:0009154]; regulation of transcription, DNA-templated [GO:0006355]; signal transduction [GO:0007165]; transcription, DNA-templated [GO:0006351]	hydrolase activity [GO:0016787]; nucleotide binding [GO:0000166]; protein kinase C binding [GO:0005080]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; histone deacetylase complex [GO:0000118]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005737; GO:0005856; GO:0070062; GO:0000118; GO:0016787; GO:0072332; GO:0000166; GO:0005634; GO:0005886; GO:0005080; GO:0009154; GO:0006355; GO:0007165; GO:0006351	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Interaction with CDK7 leads to a more nuclear localization.	3D-structure; Acetylation; Apoptosis; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Hydrolase; Neuropathy; Nucleotide-binding; Nucleus; Reference proteome; Transcription; Transcription regulation	Active site (1); Beta strand (6); Binding site (1); Chain (1); Domain (1); Helix (5); Initiator methionine (1); Modified residue (3); Motif (1); Mutagenesis (5); Natural variant (6); Nucleotide binding (3); Sequence conflict (1)
IF4H_HUMAN	Q15056	IF4H_HUMAN	reviewed	Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein)	EIF4H KIAA0038 WBSCR1 WSCR1	Homo sapiens (Human)	248	cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]; cellular protein metabolic process [GO:0044267]; developmental growth [GO:0048589]; gene expression [GO:0010467]; regulation of translational initiation [GO:0006446]; sexual reproduction [GO:0019953]; translation [GO:0006412]; translational initiation [GO:0006413]; viral process [GO:0016032]	cellular protein metabolic process [GO:0044267]; developmental growth [GO:0048589]; gene expression [GO:0010467]; regulation of translational initiation [GO:0006446]; sexual reproduction [GO:0019953]; translation [GO:0006412]; translational initiation [GO:0006413]; viral process [GO:0016032]	nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]	cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]	GO:0003723; GO:0044267; GO:0005829; GO:0048589; GO:0016281; GO:0010467; GO:0016020; GO:0000166; GO:0048471; GO:0044822; GO:0006446; GO:0019953; GO:0006412; GO:0008135; GO:0003743; GO:0006413; GO:0016032	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250}.	Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Host-virus interaction; Initiation factor; Phosphoprotein; Protein biosynthesis; RNA-binding; Reference proteome; Williams-Beuren syndrome	Alternative sequence (1); Chain (1); Domain (1); Erroneous initiation (1); Initiator methionine (1); Modified residue (4); Region (1)
UBA3_HUMAN	Q8TBC4	UBA3_HUMAN	reviewed	NEDD8-activating enzyme E1 catalytic subunit (EC 6.3.2.-) (NEDD8-activating enzyme E1C) (Ubiquitin-activating enzyme E1C) (Ubiquitin-like modifier-activating enzyme 3) (Ubiquitin-activating enzyme 3)	UBA3 UBE1C	Homo sapiens (Human)	463	cytosol [GO:0005829]; nucleus [GO:0005634]; acid-amino acid ligase activity [GO:0016881]; ATP binding [GO:0005524]; NEDD8 activating enzyme activity [GO:0019781]; protein heterodimerization activity [GO:0046982]; cellular protein modification process [GO:0006464]; endomitotic cell cycle [GO:0007113]; innate immune response [GO:0045087]; protein neddylation [GO:0045116]; proteolysis [GO:0006508]; regulation of cell cycle [GO:0051726]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]	cellular protein modification process [GO:0006464]; endomitotic cell cycle [GO:0007113]; innate immune response [GO:0045087]; protein neddylation [GO:0045116]; proteolysis [GO:0006508]; regulation of cell cycle [GO:0051726]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]	acid-amino acid ligase activity [GO:0016881]; ATP binding [GO:0005524]; NEDD8 activating enzyme activity [GO:0019781]; protein heterodimerization activity [GO:0046982]	cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0005524; GO:0019781; GO:0016881; GO:0006464; GO:0005829; GO:0007113; GO:0045087; GO:0005634; GO:0046982; GO:0045116; GO:0006508; GO:0051726; GO:0002223		3D-structure; ATP-binding; Acetylation; Alternative splicing; Cell cycle; Complete proteome; Ligase; Nucleotide-binding; Polymorphism; Reference proteome; Ubl conjugation pathway	Active site (1); Alternative sequence (1); Beta strand (19); Chain (1); Erroneous initiation (1); Helix (21); Initiator methionine (1); Modified residue (1); Mutagenesis (24); Natural variant (1); Nucleotide binding (2); Region (9); Sequence conflict (2); Site (1); Turn (5)
PP1B_HUMAN	P62140	PP1B_HUMAN	reviewed	Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53)	PPP1CB	Homo sapiens (Human)	327	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; glycogen granule [GO:0042587]; MLL5-L complex [GO:0070688]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein phosphatase type 1 complex [GO:0000164]; PTW/PP1 phosphatase complex [GO:0072357]; metal ion binding [GO:0046872]; myosin phosphatase activity [GO:0017018]; myosin-light-chain-phosphatase activity [GO:0050115]; phosphatase activity [GO:0016791]; protein kinase binding [GO:0019901]; cell division [GO:0051301]; circadian regulation of gene expression [GO:0032922]; entrainment of circadian clock by photoperiod [GO:0043153]; G2/M transition of mitotic cell cycle [GO:0000086]; glycogen metabolic process [GO:0005977]; mitotic cell cycle [GO:0000278]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; protein dephosphorylation [GO:0006470]; regulation of cell adhesion [GO:0030155]; regulation of circadian rhythm [GO:0042752]; regulation of glycogen biosynthetic process [GO:0005979]; regulation of glycogen catabolic process [GO:0005981]; small GTPase mediated signal transduction [GO:0007264]; small molecule metabolic process [GO:0044281]; transforming growth factor beta receptor signaling pathway [GO:0007179]; triglyceride catabolic process [GO:0019433]	cell division [GO:0051301]; circadian regulation of gene expression [GO:0032922]; entrainment of circadian clock by photoperiod [GO:0043153]; G2/M transition of mitotic cell cycle [GO:0000086]; glycogen metabolic process [GO:0005977]; mitotic cell cycle [GO:0000278]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; protein dephosphorylation [GO:0006470]; regulation of cell adhesion [GO:0030155]; regulation of circadian rhythm [GO:0042752]; regulation of glycogen biosynthetic process [GO:0005979]; regulation of glycogen catabolic process [GO:0005981]; small GTPase mediated signal transduction [GO:0007264]; small molecule metabolic process [GO:0044281]; transforming growth factor beta receptor signaling pathway [GO:0007179]; triglyceride catabolic process [GO:0019433]	metal ion binding [GO:0046872]; myosin-light-chain-phosphatase activity [GO:0050115]; myosin phosphatase activity [GO:0017018]; phosphatase activity [GO:0016791]; protein kinase binding [GO:0019901]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; glycogen granule [GO:0042587]; MLL5-L complex [GO:0070688]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein phosphatase type 1 complex [GO:0000164]; PTW/PP1 phosphatase complex [GO:0072357]	GO:0000086; GO:0070688; GO:0072357; GO:0051301; GO:0032922; GO:0005829; GO:0043153; GO:0070062; GO:0005925; GO:0042587; GO:0005977; GO:0046872; GO:0000278; GO:0017018; GO:0050115; GO:0030512; GO:0005730; GO:0005654; GO:0005634; GO:0016791; GO:0006470; GO:0019901; GO:0000164; GO:0030155; GO:0042752; GO:0005979; GO:0005981; GO:0007264; GO:0044281; GO:0007179; GO:0019433	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11739654}. Nucleus {ECO:0000269|PubMed:11739654}. Nucleus, nucleoplasm {ECO:0000269|PubMed:11739654}. Nucleus, nucleolus {ECO:0000269|PubMed:11739654}. Note=Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles.	Acetylation; Biological rhythms; Carbohydrate metabolism; Cell cycle; Cell division; Complete proteome; Cytoplasm; Direct protein sequencing; Glycogen metabolism; Hydrolase; Manganese; Metal-binding; Nucleus; Phosphoprotein; Protein phosphatase; Reference proteome	Active site (1); Chain (1); Initiator methionine (1); Metal binding (7); Modified residue (2); Sequence conflict (1)
KLDC2_HUMAN	Q9Y2U9	KLDC2_HUMAN	reviewed	Kelch domain-containing protein 2 (Hepatocellular carcinoma-associated antigen 33) (Host cell factor homolog LCP) (Host cell factor-like protein 1) (HCLP-1)	KLHDC2 HCA33	Homo sapiens (Human)	406	nucleus [GO:0005634]			nucleus [GO:0005634]	GO:0005634	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11384994}.	Alternative splicing; Complete proteome; Kelch repeat; Nucleus; Reference proteome; Repeat	Alternative sequence (2); Chain (1); Repeat (6); Sequence conflict (1)
PSMD3_HUMAN	O43242	PSMD3_HUMAN	reviewed	26S proteasome non-ATPase regulatory subunit 3 (26S proteasome regulatory subunit RPN3) (26S proteasome regulatory subunit S3) (Proteasome subunit p58)	PSMD3	Homo sapiens (Human)	534	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, lid subcomplex [GO:0008541]; enzyme regulator activity [GO:0030234]; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; ubiquitin-dependent protein catabolic process [GO:0006511]; viral process [GO:0016032]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; ubiquitin-dependent protein catabolic process [GO:0006511]; viral process [GO:0016032]	enzyme regulator activity [GO:0030234]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, lid subcomplex [GO:0008541]	GO:0006977; GO:0000082; GO:0031145; GO:0042590; GO:0002479; GO:0002474; GO:0006915; GO:0034641; GO:0005737; GO:0005829; GO:0030234; GO:0070062; GO:0010467; GO:0045087; GO:0016020; GO:0000278; GO:0043066; GO:0090090; GO:0051436; GO:0005654; GO:0005634; GO:0090263; GO:0051437; GO:0012501; GO:0022624; GO:0000502; GO:0008541; GO:0000209; GO:0042981; GO:0006521; GO:0051439; GO:0044281; GO:0002223; GO:0006511; GO:0016032		Alternative splicing; Complete proteome; Proteasome; Reference proteome	Alternative sequence (2); Chain (1); Compositional bias (1); Domain (1); Sequence conflict (3)
RS3A_HUMAN	P61247	RS3A_HUMAN	reviewed	40S ribosomal protein S3a (v-fos transformation effector protein) (Fte-1)	RPS3A FTE1 MFTL	Homo sapiens (Human)	264	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cell differentiation [GO:0030154]; cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; negative regulation of apoptotic process [GO:0043066]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	cell differentiation [GO:0030154]; cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; negative regulation of apoptotic process [GO:0043066]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]	GO:0003723; GO:0006614; GO:0030154; GO:0044267; GO:0005737; GO:0005829; GO:0022627; GO:0070062; GO:0005925; GO:0010467; GO:0043066; GO:0000184; GO:0005730; GO:0005634; GO:0044822; GO:0030529; GO:0003735; GO:0006412; GO:0006414; GO:0006413; GO:0006415; GO:0019058; GO:0016032; GO:0019083	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03122, ECO:0000269|PubMed:17289661}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03122}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Differentiation; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein	Chain (1); Initiator methionine (1); Modified residue (6)
XPO7_HUMAN	Q9UIA9	XPO7_HUMAN	reviewed	Exportin-7 (Exp7) (Ran-binding protein 16)	XPO7 KIAA0745 RANBP16	Homo sapiens (Human)	1087	cytoplasm [GO:0005737]; nuclear pore [GO:0005643]; nucleus [GO:0005634]; nuclear export signal receptor activity [GO:0005049]; mRNA transport [GO:0051028]; protein export from nucleus [GO:0006611]	mRNA transport [GO:0051028]; protein export from nucleus [GO:0006611]	nuclear export signal receptor activity [GO:0005049]	cytoplasm [GO:0005737]; nuclear pore [GO:0005643]; nucleus [GO:0005634]	GO:0005737; GO:0051028; GO:0005049; GO:0005643; GO:0005634; GO:0006611	SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000305}. Nucleus, nuclear pore complex {ECO:0000305}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000305}.	Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Nuclear pore complex; Nucleus; Polymorphism; Protein transport; Reference proteome; Translocation; Transport; mRNA transport	Chain (1); Domain (1); Erroneous initiation (1); Initiator methionine (1); Modified residue (1); Natural variant (2); Sequence conflict (1)
F8W543_HUMAN	F8W543	F8W543_HUMAN	unreviewed	Nucleosome assembly protein 1-like 1	NAP1L1	Homo sapiens (Human)	328	nucleus [GO:0005634]; nucleosome assembly [GO:0006334]	nucleosome assembly [GO:0006334]		nucleus [GO:0005634]	GO:0006334; GO:0005634		Complete proteome; Proteomics identification; Reference proteome	
Q6R954_HUMAN	Q6R954	Q6R954_HUMAN	unreviewed	Polymerase delta interacting protein 46 (Polymerase delta-interacting protein 3)	PDIP46 POLDIP3	Homo sapiens (Human)	185	intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]			intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]	GO:0043231; GO:0005654		Complete proteome; Proteomics identification; Reference proteome	
TYB10_HUMAN	P63313	TYB10_HUMAN	reviewed	Thymosin beta-10	TMSB10 PTMB10 THYB10	Homo sapiens (Human)	44	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; actin filament organization [GO:0007015]; sequestering of actin monomers [GO:0042989]	actin filament organization [GO:0007015]; sequestering of actin monomers [GO:0042989]		cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]	GO:0007015; GO:0005737; GO:0005856; GO:0042989	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.	Acetylation; Actin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Polymorphism; Reference proteome	Chain (1); Erroneous initiation (2); Initiator methionine (1); Modified residue (5); Natural variant (1)
KINH_HUMAN	P33176	KINH_HUMAN	reviewed	Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC)	KIF5B KNS KNS1	Homo sapiens (Human)	963	ciliary rootlet [GO:0035253]; cytoplasm [GO:0005737]; endocytic vesicle [GO:0030139]; kinesin complex [GO:0005871]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; neuron projection [GO:0043005]; perinuclear region of cytoplasm [GO:0048471]; vesicle [GO:0031982]; ATP binding [GO:0005524]; ATP-dependent microtubule motor activity, plus-end-directed [GO:0008574]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; axon guidance [GO:0007411]; cellular protein metabolic process [GO:0044267]; cytoplasm organization [GO:0007028]; cytoskeleton-dependent intracellular transport [GO:0030705]; microtubule-based movement [GO:0007018]; plus-end-directed vesicle transport along microtubule [GO:0072383]; positive regulation of establishment of protein localization to plasma membrane [GO:0090004]; positive regulation of potassium ion transport [GO:0043268]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; protein localization [GO:0008104]; regulation of membrane potential [GO:0042391]; stress granule disassembly [GO:0035617]; vesicle transport along microtubule [GO:0047496]	axon guidance [GO:0007411]; cellular protein metabolic process [GO:0044267]; cytoplasm organization [GO:0007028]; cytoskeleton-dependent intracellular transport [GO:0030705]; microtubule-based movement [GO:0007018]; plus-end-directed vesicle transport along microtubule [GO:0072383]; positive regulation of establishment of protein localization to plasma membrane [GO:0090004]; positive regulation of potassium ion transport [GO:0043268]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; protein localization [GO:0008104]; regulation of membrane potential [GO:0042391]; stress granule disassembly [GO:0035617]; vesicle transport along microtubule [GO:0047496]	ATP binding [GO:0005524]; ATP-dependent microtubule motor activity, plus-end-directed [GO:0008574]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]	ciliary rootlet [GO:0035253]; cytoplasm [GO:0005737]; endocytic vesicle [GO:0030139]; kinesin complex [GO:0005871]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; neuron projection [GO:0043005]; perinuclear region of cytoplasm [GO:0048471]; vesicle [GO:0031982]	GO:0005524; GO:0008574; GO:0007411; GO:0044267; GO:0035253; GO:0005737; GO:0007028; GO:0030705; GO:0030139; GO:0005871; GO:0016020; GO:0005874; GO:0008017; GO:0003777; GO:0005815; GO:0007018; GO:0043005; GO:0048471; GO:0072383; GO:0090004; GO:0043268; GO:0032230; GO:0008104; GO:0042391; GO:0035617; GO:0031982; GO:0047496	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Note=Uniformly distributed between soma and neurites in hippocampal neurons. {ECO:0000250}.	3D-structure; ATP-binding; Acetylation; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Motor protein; Nucleotide-binding; Phosphoprotein; Reference proteome	Beta strand (17); Chain (1); Coiled coil (1); Domain (1); Helix (15); Initiator methionine (1); Modified residue (2); Nucleotide binding (1); Region (1); Turn (4)
F8VYE8_HUMAN	F8VYE8	F8VYE8_HUMAN	unreviewed	Serine/threonine-protein phosphatase (EC 3.1.3.16)	PPP1CC	Homo sapiens (Human)	304	phosphoprotein phosphatase activity [GO:0004721]		phosphoprotein phosphatase activity [GO:0004721]		GO:0004721		Complete proteome; Hydrolase; Proteomics identification; Reference proteome	
ARBK1_HUMAN	P25098	ARBK1_HUMAN	reviewed	Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC 2.7.11.15) (G-protein coupled receptor kinase 2)	ADRBK1 BARK BARK1 GRK2	Homo sapiens (Human)	689	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]; primary cilium [GO:0072372]; alpha-2A adrenergic receptor binding [GO:0031694]; ATP binding [GO:0005524]; beta-adrenergic receptor kinase activity [GO:0047696]; Edg-2 lysophosphatidic acid receptor binding [GO:0031755]; G-protein coupled receptor kinase activity [GO:0004703]; protein kinase activity [GO:0004672]; activation of phospholipase C activity [GO:0007202]; cardiac muscle contraction [GO:0060048]; desensitization of G-protein coupled receptor protein signaling pathway [GO:0002029]; epidermal growth factor receptor signaling pathway [GO:0007173]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G-protein coupled acetylcholine receptor signaling pathway [GO:0007213]; heart development [GO:0007507]; innate immune response [GO:0045087]; negative regulation of striated muscle contraction [GO:0045988]; negative regulation of the force of heart contraction by chemical signal [GO:0003108]; neurotrophin TRK receptor signaling pathway [GO:0048011]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of catecholamine secretion [GO:0033605]; receptor internalization [GO:0031623]; signal transduction [GO:0007165]; tachykinin receptor signaling pathway [GO:0007217]; termination of G-protein coupled receptor signaling pathway [GO:0038032]; viral entry into host cell [GO:0046718]; viral genome replication [GO:0019079]	activation of phospholipase C activity [GO:0007202]; cardiac muscle contraction [GO:0060048]; desensitization of G-protein coupled receptor protein signaling pathway [GO:0002029]; epidermal growth factor receptor signaling pathway [GO:0007173]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G-protein coupled acetylcholine receptor signaling pathway [GO:0007213]; heart development [GO:0007507]; innate immune response [GO:0045087]; negative regulation of striated muscle contraction [GO:0045988]; negative regulation of the force of heart contraction by chemical signal [GO:0003108]; neurotrophin TRK receptor signaling pathway [GO:0048011]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of catecholamine secretion [GO:0033605]; receptor internalization [GO:0031623]; signal transduction [GO:0007165]; tachykinin receptor signaling pathway [GO:0007217]; termination of G-protein coupled receptor signaling pathway [GO:0038032]; viral entry into host cell [GO:0046718]; viral genome replication [GO:0019079]	alpha-2A adrenergic receptor binding [GO:0031694]; ATP binding [GO:0005524]; beta-adrenergic receptor kinase activity [GO:0047696]; Edg-2 lysophosphatidic acid receptor binding [GO:0031755]; G-protein coupled receptor kinase activity [GO:0004703]; protein kinase activity [GO:0004672]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; plasma membrane [GO:0005886]; primary cilium [GO:0072372]	GO:0005524; GO:0031755; GO:0007213; GO:0004703; GO:0007202; GO:0031694; GO:0047696; GO:0060048; GO:0005737; GO:0005829; GO:0002029; GO:0007173; GO:0008543; GO:0007507; GO:0045087; GO:0016020; GO:0045988; GO:0003108; GO:0048011; GO:0018105; GO:0018107; GO:0005886; GO:0033605; GO:0072372; GO:0004672; GO:0031623; GO:0007165; GO:0007217; GO:0038032; GO:0046718; GO:0019079	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P21146}. Cell membrane {ECO:0000250|UniProtKB:P21146}.	3D-structure; ATP-binding; Cell membrane; Complete proteome; Cytoplasm; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase	Active site (1); Beta strand (22); Binding site (1); Chain (1); Domain (4); Helix (34); Modified residue (1); Natural variant (2); Nucleotide binding (1); Region (1); Sequence conflict (6); Turn (7)
EFHD2_HUMAN	Q96C19	EFHD2_HUMAN	reviewed	EF-hand domain-containing protein D2 (Swiprosin-1)	EFHD2 SWS1	Homo sapiens (Human)	240	membrane raft [GO:0045121]; calcium ion binding [GO:0005509]		calcium ion binding [GO:0005509]	membrane raft [GO:0045121]	GO:0005509; GO:0045121	SUBCELLULAR LOCATION: Membrane raft {ECO:0000250}. Note=In a mouse immature B-cell line WEHI-231. {ECO:0000250}.	Acetylation; Calcium; Complete proteome; Direct protein sequencing; Membrane; Metal-binding; Phosphoprotein; Reference proteome; Repeat	Calcium binding (2); Chain (1); Domain (2); Initiator methionine (1); Modified residue (6)
FCL_HUMAN	Q13630	FCL_HUMAN	reviewed	GDP-L-fucose synthase (EC 1.1.1.271) (GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase) (Protein FX) (Red cell NADP(H)-binding protein) (Short-chain dehydrogenase/reductase family 4E member 1)	TSTA3 SDR4E1	Homo sapiens (Human)	321	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; coenzyme binding [GO:0050662]; electron carrier activity [GO:0009055]; GDP-4-dehydro-D-rhamnose reductase activity [GO:0042356]; GDP-L-fucose synthase activity [GO:0050577]; isomerase activity [GO:0016853]; 'de novo' GDP-L-fucose biosynthetic process [GO:0042351]; cytolysis [GO:0019835]; GDP-mannose metabolic process [GO:0019673]; leukocyte cell-cell adhesion [GO:0007159]	'de novo' GDP-L-fucose biosynthetic process [GO:0042351]; cytolysis [GO:0019835]; GDP-mannose metabolic process [GO:0019673]; leukocyte cell-cell adhesion [GO:0007159]	coenzyme binding [GO:0050662]; electron carrier activity [GO:0009055]; GDP-4-dehydro-D-rhamnose reductase activity [GO:0042356]; GDP-L-fucose synthase activity [GO:0050577]; isomerase activity [GO:0016853]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]	GO:0042351; GO:0042356; GO:0050577; GO:0019673; GO:0050662; GO:0019835; GO:0005737; GO:0009055; GO:0070062; GO:0016853; GO:0007159		3D-structure; Complete proteome; Direct protein sequencing; Isomerase; Multifunctional enzyme; NADP; Oxidoreductase; Reference proteome	Active site (1); Beta strand (16); Binding site (6); Chain (1); Helix (12); Nucleotide binding (2); Sequence conflict (1); Site (3); Turn (5)
CAP1_HUMAN	Q01518	CAP1_HUMAN	reviewed	Adenylyl cyclase-associated protein 1 (CAP 1)	CAP1 CAP	Homo sapiens (Human)	475	cortical actin cytoskeleton [GO:0030864]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; actin cytoskeleton organization [GO:0030036]; activation of adenylate cyclase activity [GO:0007190]; ameboidal-type cell migration [GO:0001667]; axon guidance [GO:0007411]; blood coagulation [GO:0007596]; establishment or maintenance of cell polarity [GO:0007163]; platelet activation [GO:0030168]; platelet degranulation [GO:0002576]; receptor-mediated endocytosis [GO:0006898]; signal transduction [GO:0007165]	actin cytoskeleton organization [GO:0030036]; activation of adenylate cyclase activity [GO:0007190]; ameboidal-type cell migration [GO:0001667]; axon guidance [GO:0007411]; blood coagulation [GO:0007596]; establishment or maintenance of cell polarity [GO:0007163]; platelet activation [GO:0030168]; platelet degranulation [GO:0002576]; receptor-mediated endocytosis [GO:0006898]; signal transduction [GO:0007165]		cortical actin cytoskeleton [GO:0030864]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]	GO:0030036; GO:0007190; GO:0001667; GO:0007411; GO:0007596; GO:0030864; GO:0007163; GO:0070062; GO:0005925; GO:0005886; GO:0030168; GO:0002576; GO:0006898; GO:0007165	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.	3D-structure; Acetylation; Actin-binding; Alternative splicing; Cell membrane; Complete proteome; Direct protein sequencing; Membrane; Phosphoprotein; Polymorphism; Reference proteome	Alternative sequence (1); Beta strand (14); Chain (1); Compositional bias (2); Domain (1); Initiator methionine (1); Modified residue (10); Natural variant (6); Sequence conflict (1); Turn (1)
D6REZ0_HUMAN	D6REZ0	D6REZ0_HUMAN	unreviewed	Rap1 GTPase-GDP dissociation stimulator 1 (Fragment)	RAP1GDS1	Homo sapiens (Human)	158							Complete proteome; Proteomics identification; Reference proteome	Non-terminal residue (1)
T2EA_HUMAN	P29083	T2EA_HUMAN	reviewed	General transcription factor IIE subunit 1 (General transcription factor IIE 56 kDa subunit) (Transcription initiation factor IIE subunit alpha) (TFIIE-alpha)	GTF2E1 TF2E1	Homo sapiens (Human)	439	intermediate filament cytoskeleton [GO:0045111]; nucleoplasm [GO:0005654]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; gene expression [GO:0010467]; regulation of transcription, DNA-templated [GO:0006355]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]; viral process [GO:0016032]	gene expression [GO:0010467]; regulation of transcription, DNA-templated [GO:0006355]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]; viral process [GO:0016032]	metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]	intermediate filament cytoskeleton [GO:0045111]; nucleoplasm [GO:0005654]	GO:0010467; GO:0045111; GO:0046872; GO:0005654; GO:0006355; GO:0043565; GO:0006368; GO:0006366; GO:0006367; GO:0016032	SUBCELLULAR LOCATION: Nucleus.	3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Host-virus interaction; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger	Beta strand (10); Chain (1); Compositional bias (1); Domain (1); Helix (4); Initiator methionine (1); Modified residue (3); Natural variant (1); Sequence conflict (1); Turn (1); Zinc finger (1)
SAE2_HUMAN	Q9UBT2	SAE2_HUMAN	reviewed	SUMO-activating enzyme subunit 2 (EC 6.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2)	UBA2 SAE2 UBLE1B HRIHFB2115	Homo sapiens (Human)	640	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SUMO activating enzyme complex [GO:0031510]; ATP binding [GO:0005524]; enzyme activator activity [GO:0008047]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; SUMO activating enzyme activity [GO:0019948]; cellular protein metabolic process [GO:0044267]; positive regulation of catalytic activity [GO:0043085]; post-translational protein modification [GO:0043687]; protein sumoylation [GO:0016925]	cellular protein metabolic process [GO:0044267]; positive regulation of catalytic activity [GO:0043085]; post-translational protein modification [GO:0043687]; protein sumoylation [GO:0016925]	ATP binding [GO:0005524]; enzyme activator activity [GO:0008047]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; SUMO activating enzyme activity [GO:0019948]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SUMO activating enzyme complex [GO:0031510]	GO:0005524; GO:0019948; GO:0031510; GO:0044267; GO:0005829; GO:0008047; GO:0046872; GO:0005654; GO:0005634; GO:0043085; GO:0043687; GO:0046982; GO:0016925	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus, sumoylation is required either for nuclear translocation or nuclear retention.	3D-structure; ATP-binding; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Isopeptide bond; Ligase; Metal-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation; Ubl conjugation pathway; Zinc	Active site (1); Alternative sequence (1); Beta strand (21); Binding site (2); Chain (1); Cross-link (9); Helix (27); Metal binding (4); Modified residue (5); Mutagenesis (12); Natural variant (1); Nucleotide binding (4); Sequence conflict (4); Turn (8)
MAP1A_HUMAN	P78559	MAP1A_HUMAN	reviewed	Microtubule-associated protein 1A (MAP-1A) (Proliferation-related protein p80) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2]	MAP1A MAP1L	Homo sapiens (Human)	2803	cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; structural molecule activity [GO:0005198]; activation of mitophagy in response to mitochondrial depolarization [GO:0098779]; microtubule cytoskeleton organization [GO:0000226]; positive regulation of defense response to virus by host [GO:0002230]; sensory perception of sound [GO:0007605]	activation of mitophagy in response to mitochondrial depolarization [GO:0098779]; microtubule cytoskeleton organization [GO:0000226]; positive regulation of defense response to virus by host [GO:0002230]; sensory perception of sound [GO:0007605]	structural molecule activity [GO:0005198]	cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]	GO:0098779; GO:0005829; GO:0005874; GO:0005875; GO:0000226; GO:0002230; GO:0007605; GO:0005198	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.	Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Phosphoprotein; Polymorphism; Reference proteome; Repeat	Alternative sequence (1); Chain (3); Compositional bias (1); Modified residue (25); Natural variant (27); Region (1); Repeat (9); Sequence conflict (47)
ZCCHV_HUMAN	Q7Z2W4	ZCCHV_HUMAN	reviewed	Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP)	ZC3HAV1 ZC3HDC2 PRO1677	Homo sapiens (Human)	902	cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; poly(A) RNA binding [GO:0044822]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of viral genome replication [GO:0045071]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of RIG-I signaling pathway [GO:1900246]; response to virus [GO:0009615]	defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of viral genome replication [GO:0045071]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of RIG-I signaling pathway [GO:1900246]; response to virus [GO:0009615]	metal ion binding [GO:0046872]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; poly(A) RNA binding [GO:0044822]	cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]	GO:0005794; GO:0003950; GO:0005737; GO:0051607; GO:0045087; GO:0046872; GO:0045071; GO:0005634; GO:0044822; GO:0043123; GO:1900246; GO:0032727; GO:0032728; GO:0061014; GO:0009615	SUBCELLULAR LOCATION: Isoform 1: Cytoplasm. Nucleus. Note=Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner. {ECO:0000250}.; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm.	3D-structure; Acetylation; Alternative splicing; Antiviral defense; Complete proteome; Cytoplasm; Immunity; Innate immunity; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; RNA-binding; Reference proteome; Repeat; Zinc; Zinc-finger	Alternative sequence (4); Beta strand (11); Chain (1); Domain (2); Helix (8); Initiator methionine (1); Modified residue (15); Motif (2); Natural variant (4); Region (2); Sequence conflict (1); Zinc finger (4)
LYSM2_HUMAN	Q8IV50	LYSM2_HUMAN	reviewed	LysM and putative peptidoglycan-binding domain-containing protein 2	LYSMD2	Homo sapiens (Human)	215							Acetylation; Alternative splicing; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome	Alternative sequence (1); Chain (1); Initiator methionine (1); Modified residue (4); Natural variant (2); Repeat (1)
PRS6B_HUMAN	P43686	PRS6B_HUMAN	reviewed	26S protease regulatory subunit 6B (26S proteasome AAA-ATPase subunit RPT3) (MB67-interacting protein) (MIP224) (Proteasome 26S subunit ATPase 4) (Tat-binding protein 7) (TBP-7)	PSMC4 MIP224 TBP7	Homo sapiens (Human)	418	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic proteasome complex [GO:0031597]; inclusion body [GO:0016234]; membrane [GO:0016020]; nuclear proteasome complex [GO:0031595]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; proteasome-activating ATPase activity [GO:0036402]; TBP-class protein binding [GO:0017025]; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; blastocyst development [GO:0001824]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [GO:0045899]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; protein polyubiquitination [GO:0000209]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; blastocyst development [GO:0001824]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [GO:0045899]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; protein polyubiquitination [GO:0000209]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	ATPase activity [GO:0016887]; ATP binding [GO:0005524]; proteasome-activating ATPase activity [GO:0036402]; TBP-class protein binding [GO:0017025]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic proteasome complex [GO:0031597]; inclusion body [GO:0016234]; membrane [GO:0016020]; nuclear proteasome complex [GO:0031595]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]	GO:0005524; GO:0016887; GO:0006977; GO:0030433; GO:0000082; GO:0017025; GO:0031145; GO:0042590; GO:0002479; GO:0002474; GO:0006915; GO:0001824; GO:0034641; GO:0005737; GO:0005829; GO:0031597; GO:0010467; GO:0016234; GO:0045087; GO:0016020; GO:0000278; GO:0043066; GO:0090090; GO:0051436; GO:0031595; GO:0005654; GO:0005634; GO:0045899; GO:0090263; GO:1901800; GO:0051437; GO:0012501; GO:0022624; GO:0000502; GO:0008540; GO:0036402; GO:0000209; GO:0006508; GO:0042981; GO:0006521; GO:0051439; GO:0044281; GO:0002223; GO:0016032	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.	3D-structure; ATP-binding; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleotide-binding; Nucleus; Phosphoprotein; Proteasome; Reference proteome	Alternative sequence (1); Beta strand (1); Chain (1); Helix (4); Modified residue (6); Nucleotide binding (1); Sequence conflict (5); Turn (1)
DPP3_HUMAN	Q9NY33	DPP3_HUMAN	reviewed	Dipeptidyl peptidase 3 (EC 3.4.14.4) (Dipeptidyl aminopeptidase III) (Dipeptidyl arylamidase III) (Dipeptidyl peptidase III) (DPP III) (Enkephalinase B)	DPP3	Homo sapiens (Human)	737	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; dipeptidyl-peptidase activity [GO:0008239]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270]; proteolysis [GO:0006508]	proteolysis [GO:0006508]	dipeptidyl-peptidase activity [GO:0008239]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	GO:0005737; GO:0008239; GO:0070062; GO:0008237; GO:0005654; GO:0005886; GO:0006508; GO:0008270	SUBCELLULAR LOCATION: Cytoplasm.	3D-structure; Acetylation; Alternative splicing; Aminopeptidase; Complete proteome; Cytoplasm; Hydrolase; Metal-binding; Metalloprotease; Polymorphism; Protease; Reference proteome; Zinc	Active site (1); Alternative sequence (2); Beta strand (27); Chain (1); Helix (38); Initiator methionine (1); Mass spectrometry (1); Metal binding (3); Modified residue (1); Natural variant (4); Sequence conflict (3); Turn (8)
RBX2_HUMAN	Q9UBF6	RBX2_HUMAN	reviewed	RING-box protein 2 (Rbx2) (CKII beta-binding protein 1) (CKBBP1) (RING finger protein 7) (Regulator of cullins 2) (Sensitive to apoptosis gene protein)	RNF7 RBX2 ROC2 SAG	Homo sapiens (Human)	113	Cul2-RING ubiquitin ligase complex [GO:0031462]; Cul3-RING ubiquitin ligase complex [GO:0031463]; Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul5-RING ubiquitin ligase complex [GO:0031466]; Cul7-RING ubiquitin ligase complex [GO:0031467]; cytoplasm [GO:0005737]; nuclear SCF ubiquitin ligase complex [GO:0043224]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; copper ion binding [GO:0005507]; cullin family protein binding [GO:0097602]; NEDD8 transferase activity [GO:0019788]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; protein neddylation [GO:0045116]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; response to redox state [GO:0051775]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	protein neddylation [GO:0045116]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; response to redox state [GO:0051775]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]	copper ion binding [GO:0005507]; cullin family protein binding [GO:0097602]; NEDD8 transferase activity [GO:0019788]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]	Cul2-RING ubiquitin ligase complex [GO:0031462]; Cul3-RING ubiquitin ligase complex [GO:0031463]; Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul5-RING ubiquitin ligase complex [GO:0031466]; Cul7-RING ubiquitin ligase complex [GO:0031467]; cytoplasm [GO:0005737]; nuclear SCF ubiquitin ligase complex [GO:0043224]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0031462; GO:0031463; GO:0080008; GO:0031466; GO:0031467; GO:0019788; GO:0031146; GO:0005507; GO:0097602; GO:0005737; GO:0043224; GO:0005654; GO:0005634; GO:0045116; GO:0042787; GO:0051775; GO:0061630; GO:0008270	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10082581}. Nucleus {ECO:0000269|PubMed:10082581}.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation pathway; Zinc; Zinc-finger	Alternative sequence (3); Beta strand (3); Chain (1); Helix (2); Initiator methionine (1); Metal binding (12); Modified residue (2); Sequence conflict (1); Turn (4); Zinc finger (1)
KPCA_HUMAN	P17252	KPCA_HUMAN	reviewed	Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13)	PRKCA PKCA PRKACA	Homo sapiens (Human)	672	apical part of cell [GO:0045177]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; calcium-dependent protein kinase C activity [GO:0004698]; enzyme binding [GO:0019899]; histone kinase activity (H3-T6 specific) [GO:0035403]; protein kinase activity [GO:0004672]; protein kinase C activity [GO:0004697]; protein serine/threonine kinase activity [GO:0004674]; zinc ion binding [GO:0008270]; activation of adenylate cyclase activity [GO:0007190]; activation of phospholipase C activity [GO:0007202]; angiogenesis [GO:0001525]; apoptotic signaling pathway [GO:0097190]; blood coagulation [GO:0007596]; cell adhesion [GO:0007155]; cellular calcium ion homeostasis [GO:0006874]; cellular response to carbohydrate stimulus [GO:0071322]; chondrocyte differentiation [GO:0002062]; desmosome assembly [GO:0002159]; energy reserve metabolic process [GO:0006112]; epidermal growth factor receptor signaling pathway [GO:0007173]; extracellular matrix organization [GO:0030198]; fibroblast growth factor receptor signaling pathway [GO:0008543]; gene expression [GO:0010467]; histone H3-T6 phosphorylation [GO:0035408]; inactivation of MAPK activity [GO:0000188]; induction of positive chemotaxis [GO:0050930]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway [GO:0097193]; mitotic cell cycle [GO:0000278]; mitotic nuclear envelope disassembly [GO:0007077]; negative regulation of adenylate cyclase activity [GO:0007194]; negative regulation of cell proliferation [GO:0008285]; negative regulation of glial cell apoptotic process [GO:0034351]; negative regulation of glucose import [GO:0046325]; negative regulation of insulin receptor signaling pathway [GO:0046627]; neurotrophin TRK receptor signaling pathway [GO:0048011]; neutrophil chemotaxis [GO:0030593]; peptidyl-serine autophosphorylation [GO:0036289]; phototransduction, visible light [GO:0007603]; platelet activation [GO:0030168]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; positive regulation of dense core granule biogenesis [GO:2000707]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of inflammatory response [GO:0050729]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of mitotic cell cycle [GO:0045931]; protein phosphorylation [GO:0006468]; regulation of insulin secretion [GO:0050796]; regulation of muscle contraction [GO:0006937]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; regulation of platelet aggregation [GO:0090330]; regulation of rhodopsin mediated signaling pathway [GO:0022400]; regulation of the force of heart contraction [GO:0002026]; response to interleukin-1 [GO:0070555]; rhodopsin mediated signaling pathway [GO:0016056]; signal transduction [GO:0007165]; small molecule metabolic process [GO:0044281]; synaptic transmission [GO:0007268]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	activation of adenylate cyclase activity [GO:0007190]; activation of phospholipase C activity [GO:0007202]; angiogenesis [GO:0001525]; apoptotic signaling pathway [GO:0097190]; blood coagulation [GO:0007596]; cell adhesion [GO:0007155]; cellular calcium ion homeostasis [GO:0006874]; cellular response to carbohydrate stimulus [GO:0071322]; chondrocyte differentiation [GO:0002062]; desmosome assembly [GO:0002159]; energy reserve metabolic process [GO:0006112]; epidermal growth factor receptor signaling pathway [GO:0007173]; extracellular matrix organization [GO:0030198]; fibroblast growth factor receptor signaling pathway [GO:0008543]; gene expression [GO:0010467]; histone H3-T6 phosphorylation [GO:0035408]; inactivation of MAPK activity [GO:0000188]; induction of positive chemotaxis [GO:0050930]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway [GO:0097193]; mitotic cell cycle [GO:0000278]; mitotic nuclear envelope disassembly [GO:0007077]; negative regulation of adenylate cyclase activity [GO:0007194]; negative regulation of cell proliferation [GO:0008285]; negative regulation of glial cell apoptotic process [GO:0034351]; negative regulation of glucose import [GO:0046325]; negative regulation of insulin receptor signaling pathway [GO:0046627]; neurotrophin TRK receptor signaling pathway [GO:0048011]; neutrophil chemotaxis [GO:0030593]; peptidyl-serine autophosphorylation [GO:0036289]; phototransduction, visible light [GO:0007603]; platelet activation [GO:0030168]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; positive regulation of dense core granule biogenesis [GO:2000707]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of inflammatory response [GO:0050729]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of mitotic cell cycle [GO:0045931]; protein phosphorylation [GO:0006468]; regulation of insulin secretion [GO:0050796]; regulation of muscle contraction [GO:0006937]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; regulation of platelet aggregation [GO:0090330]; regulation of rhodopsin mediated signaling pathway [GO:0022400]; regulation of the force of heart contraction [GO:0002026]; response to interleukin-1 [GO:0070555]; rhodopsin mediated signaling pathway [GO:0016056]; signal transduction [GO:0007165]; small molecule metabolic process [GO:0044281]; synaptic transmission [GO:0007268]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	ATP binding [GO:0005524]; calcium-dependent protein kinase C activity [GO:0004698]; enzyme binding [GO:0019899]; histone kinase activity (H3-T6 specific) [GO:0035403]; protein kinase activity [GO:0004672]; protein kinase C activity [GO:0004697]; protein serine/threonine kinase activity [GO:0004674]; zinc ion binding [GO:0008270]	apical part of cell [GO:0045177]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]	GO:0005524; GO:0007190; GO:0007202; GO:0001525; GO:0045177; GO:0097190; GO:0007596; GO:0004698; GO:0007155; GO:0006874; GO:0071322; GO:0002062; GO:0005737; GO:0005829; GO:0030425; GO:0002159; GO:0005783; GO:0006112; GO:0019899; GO:0007173; GO:0070062; GO:0030198; GO:0008543; GO:0010467; GO:0035408; GO:0035403; GO:0000188; GO:0050930; GO:0045087; GO:0097193; GO:0031966; GO:0005739; GO:0000278; GO:0007077; GO:0007194; GO:0008285; GO:0034351; GO:0046325; GO:0046627; GO:0043025; GO:0048011; GO:0030593; GO:0005654; GO:0036289; GO:0048471; GO:0001750; GO:0007603; GO:0005886; GO:0030168; GO:0070374; GO:0045766; GO:0043536; GO:0010613; GO:0045785; GO:0030335; GO:2000707; GO:0010595; GO:0001938; GO:0050729; GO:0031666; GO:0045651; GO:0045931; GO:0004697; GO:0004672; GO:0006468; GO:0004674; GO:0050796; GO:0006937; GO:0050730; GO:0090330; GO:0022400; GO:0002026; GO:0070555; GO:0016056; GO:0007165; GO:0044281; GO:0007268; GO:0048010; GO:0008270	SUBCELLULAR LOCATION: Cytoplasm. Cell membrane; Peripheral membrane protein. Mitochondrion membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Nucleus.	3D-structure; ATP-binding; Acetylation; Angiogenesis; Apoptosis; Calcium; Cell adhesion; Cell membrane; Complete proteome; Cytoplasm; Direct protein sequencing; Kinase; Membrane; Metal-binding; Mitochondrion; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Proto-oncogene; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger	Active site (1); Beta strand (22); Binding site (3); Chain (1); Domain (3); Helix (20); Initiator methionine (1); Metal binding (13); Modified residue (9); Natural variant (4); Nucleotide binding (1); Sequence conflict (1); Turn (2); Zinc finger (2)
CDC73_HUMAN	Q6P1J9	CDC73_HUMAN	reviewed	Parafibromin (Cell division cycle protein 73 homolog) (Hyperparathyroidism 2 protein)	CDC73 C1orf28 HRPT2	Homo sapiens (Human)	531	Cdc73/Paf1 complex [GO:0016593]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II core binding [GO:0000993]; cell cycle [GO:0007049]; cellular response to lipopolysaccharide [GO:0071222]; endodermal cell fate commitment [GO:0001711]; histone H2B ubiquitination [GO:0033523]; histone monoubiquitination [GO:0010390]; mRNA polyadenylation [GO:0006378]; negative regulation of cell proliferation [GO:0008285]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of mRNA 3'-end processing [GO:0031442]; positive regulation of transcription elongation from RNA polymerase II promoter [GO:0032968]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of Wnt signaling pathway [GO:0030177]; protein destabilization [GO:0031648]; stem cell maintenance [GO:0019827]; transcription, DNA-templated [GO:0006351]; Wnt signaling pathway [GO:0016055]	cell cycle [GO:0007049]; cellular response to lipopolysaccharide [GO:0071222]; endodermal cell fate commitment [GO:0001711]; histone H2B ubiquitination [GO:0033523]; histone monoubiquitination [GO:0010390]; mRNA polyadenylation [GO:0006378]; negative regulation of cell proliferation [GO:0008285]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of mRNA 3'-end processing [GO:0031442]; positive regulation of transcription elongation from RNA polymerase II promoter [GO:0032968]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of Wnt signaling pathway [GO:0030177]; protein destabilization [GO:0031648]; stem cell maintenance [GO:0019827]; transcription, DNA-templated [GO:0006351]; Wnt signaling pathway [GO:0016055]	RNA polymerase II core binding [GO:0000993]	Cdc73/Paf1 complex [GO:0016593]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0016593; GO:0000993; GO:0016055; GO:0007049; GO:0071222; GO:0001711; GO:0033523; GO:0010390; GO:0006378; GO:2000134; GO:0008285; GO:0050680; GO:0048147; GO:0045638; GO:0000122; GO:0005654; GO:0005634; GO:0030177; GO:0031442; GO:0032968; GO:0045944; GO:0031648; GO:0019827; GO:0006351	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15580289, ECO:0000269|PubMed:15632063, ECO:0000269|PubMed:15923622}.	Acetylation; Cell cycle; Complete proteome; Direct protein sequencing; Disease mutation; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Tumor suppressor; Wnt signaling pathway	Chain (1); Compositional bias (1); Erroneous initiation (1); Initiator methionine (1); Modified residue (2); Motif (1); Natural variant (12); Region (2); Sequence caution (1); Sequence conflict (3)
CHRC1_HUMAN	Q9NRG0	CHRC1_HUMAN	reviewed	Chromatin accessibility complex protein 1 (CHRAC-1) (Chromatin accessibility complex 15 kDa protein) (CHRAC-15) (HuCHRAC15) (DNA polymerase epsilon subunit p15)	CHRAC1 CHRAC15	Homo sapiens (Human)	131	CHRAC [GO:0008623]; epsilon DNA polymerase complex [GO:0008622]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; sequence-specific DNA binding [GO:0043565]; chromatin remodeling [GO:0006338]; DNA biosynthetic process [GO:0071897]	chromatin remodeling [GO:0006338]; DNA biosynthetic process [GO:0071897]	DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; sequence-specific DNA binding [GO:0043565]	CHRAC [GO:0008623]; epsilon DNA polymerase complex [GO:0008622]	GO:0008623; GO:0003677; GO:0071897; GO:0003887; GO:0006338; GO:0008622; GO:0043565	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.	Acetylation; Coiled coil; Complete proteome; DNA-binding; DNA-directed DNA polymerase; Nucleotidyltransferase; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transferase	Chain (1); Coiled coil (1); Initiator methionine (1); Modified residue (3); Natural variant (2)
E5RGS9_HUMAN	E5RGS9	E5RGS9_HUMAN	unreviewed	Chromatin accessibility complex protein 1	CHRAC1	Homo sapiens (Human)	56	intracellular [GO:0005622]; sequence-specific DNA binding [GO:0043565]		sequence-specific DNA binding [GO:0043565]	intracellular [GO:0005622]	GO:0005622; GO:0043565		Complete proteome; Proteomics identification; Reference proteome	
PA24B_HUMAN	P0C869	PA24B_HUMAN	reviewed	Cytosolic phospholipase A2 beta (cPLA2-beta) (EC 3.1.1.4) (Phospholipase A2 group IVB)	PLA2G4B	Homo sapiens (Human)	781	cytosol [GO:0005829]; early endosome membrane [GO:0031901]; extracellular region [GO:0005576]; mitochondrial inner membrane [GO:0005743]; calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-dependent phospholipid binding [GO:0005544]; lysophospholipase activity [GO:0004622]; arachidonic acid metabolic process [GO:0019369]; calcium-mediated signaling [GO:0019722]; cellular protein metabolic process [GO:0044267]; endoplasmic reticulum unfolded protein response [GO:0030968]; glycerophospholipid biosynthetic process [GO:0046474]; glycerophospholipid catabolic process [GO:0046475]; inflammatory response [GO:0006954]; IRE1-mediated unfolded protein response [GO:0036498]; parturition [GO:0007567]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phosphatidylserine acyl-chain remodeling [GO:0036150]; phospholipid metabolic process [GO:0006644]; small molecule metabolic process [GO:0044281]	arachidonic acid metabolic process [GO:0019369]; calcium-mediated signaling [GO:0019722]; cellular protein metabolic process [GO:0044267]; endoplasmic reticulum unfolded protein response [GO:0030968]; glycerophospholipid biosynthetic process [GO:0046474]; glycerophospholipid catabolic process [GO:0046475]; inflammatory response [GO:0006954]; IRE1-mediated unfolded protein response [GO:0036498]; parturition [GO:0007567]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phosphatidylserine acyl-chain remodeling [GO:0036150]; phospholipid metabolic process [GO:0006644]; small molecule metabolic process [GO:0044281]	calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-dependent phospholipid binding [GO:0005544]; calcium ion binding [GO:0005509]; lysophospholipase activity [GO:0004622]	cytosol [GO:0005829]; early endosome membrane [GO:0031901]; extracellular region [GO:0005576]; mitochondrial inner membrane [GO:0005743]	GO:0036498; GO:0019369; GO:0005509; GO:0047498; GO:0005544; GO:0019722; GO:0044267; GO:0005829; GO:0031901; GO:0030968; GO:0005576; GO:0046474; GO:0046475; GO:0006954; GO:0004622; GO:0005743; GO:0007567; GO:0006654; GO:0036151; GO:0036152; GO:0036148; GO:0036150; GO:0006644; GO:0044281	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:16617059}.; SUBCELLULAR LOCATION: Isoform 3: Mitochondrion membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Note=Translocates to membrane vesicles in a calcium-dependent fashion.	Alternative splicing; Calcium; Complete proteome; Cytoplasm; Endosome; Hydrolase; Lipid degradation; Lipid metabolism; Membrane; Metal-binding; Mitochondrion; Polymorphism; Reference proteome	Active site (2); Alternative sequence (5); Chain (1); Domain (2); Erroneous initiation (1); Mutagenesis (4); Natural variant (4); Sequence conflict (7)
COG3_HUMAN	Q96JB2	COG3_HUMAN	reviewed	Conserved oligomeric Golgi complex subunit 3 (COG complex subunit 3) (Component of oligomeric Golgi complex 3) (Vesicle-docking protein SEC34 homolog) (p94)	COG3 SEC34	Homo sapiens (Human)	828	cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi transport complex [GO:0017119]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; protein transporter activity [GO:0008565]; ER to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; protein glycosylation [GO:0006486]; protein localization to organelle [GO:0033365]; protein stabilization [GO:0050821]; retrograde transport, vesicle recycling within Golgi [GO:0000301]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]	ER to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein glycosylation [GO:0006486]; protein localization to organelle [GO:0033365]; protein stabilization [GO:0050821]; retrograde transport, vesicle recycling within Golgi [GO:0000301]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]	protein transporter activity [GO:0008565]	cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi transport complex [GO:0017119]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	GO:0006888; GO:0005794; GO:0032580; GO:0007030; GO:0017119; GO:0005801; GO:0005737; GO:0006891; GO:0006886; GO:0005654; GO:0005886; GO:0006486; GO:0033365; GO:0050821; GO:0008565; GO:0000301; GO:0006890	SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:11292827}; Peripheral membrane protein {ECO:0000269|PubMed:11292827}. Note=Associated with the peripheral membrane of cis/medial cisternae.	Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Golgi apparatus; Membrane; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport	Alternative sequence (2); Chain (1); Initiator methionine (1); Modified residue (2); Natural variant (2); Sequence conflict (4)
PP1RB_HUMAN	O60927	PP1RB_HUMAN	reviewed	Protein phosphatase 1 regulatory subunit 11 (Hemochromatosis candidate gene V protein) (HCG V) (Protein phosphatase inhibitor 3)	PPP1R11 HCGV TCTE5	Homo sapiens (Human)	126	cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein phosphatase type 1 complex [GO:0000164]; protein phosphatase 1 binding [GO:0008157]; protein serine/threonine phosphatase inhibitor activity [GO:0004865]; negative regulation of phosphoprotein phosphatase activity [GO:0032515]; negative regulation of protein dephosphorylation [GO:0035308]	negative regulation of phosphoprotein phosphatase activity [GO:0032515]; negative regulation of protein dephosphorylation [GO:0035308]	protein phosphatase 1 binding [GO:0008157]; protein serine/threonine phosphatase inhibitor activity [GO:0004865]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein phosphatase type 1 complex [GO:0000164]	GO:0005737; GO:0032515; GO:0035308; GO:0005634; GO:0008157; GO:0000164; GO:0004865		Acetylation; Complete proteome; Phosphoprotein; Protein phosphatase inhibitor; Reference proteome	Chain (1); Compositional bias (1); Initiator methionine (1); Modified residue (6)
ARAP1_HUMAN	Q96P48	ARAP1_HUMAN	reviewed	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Centaurin-delta-2) (Cnt-d2)	ARAP1 CENTD2 KIAA0782	Homo sapiens (Human)	1450	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; actin filament reorganization involved in cell cycle [GO:0030037]; negative regulation of stress fiber assembly [GO:0051497]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of GTPase activity [GO:0043547]; positive regulation of receptor recycling [GO:0001921]; regulation of cell shape [GO:0008360]; regulation of cellular component movement [GO:0051270]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]	actin filament reorganization involved in cell cycle [GO:0030037]; negative regulation of stress fiber assembly [GO:0051497]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of GTPase activity [GO:0043547]; positive regulation of receptor recycling [GO:0001921]; regulation of cell shape [GO:0008360]; regulation of cellular component movement [GO:0051270]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]	GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]	GO:0005096; GO:0005794; GO:0032580; GO:0030037; GO:0031410; GO:0005829; GO:0046872; GO:0051497; GO:0005547; GO:0005886; GO:0043547; GO:0051491; GO:0001921; GO:0008360; GO:0051270; GO:0051056; GO:0007264; GO:0005802	SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell membrane. Note=Associated with Golgi stacks in resting cells. Throughout the cytoplasm and in surface protrusion in cells that are in the process of attaching to a surface and spreading.	Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; GTPase activation; Golgi apparatus; Membrane; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Zinc; Zinc-finger	Alternative sequence (7); Chain (1); Domain (8); Erroneous initiation (2); Modified residue (6); Natural variant (2); Sequence conflict (1); Zinc finger (1)
EFTU_HUMAN	P49411	EFTU_HUMAN	reviewed	Elongation factor Tu, mitochondrial (EF-Tu) (P43)	TUFM	Homo sapiens (Human)	452	extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; poly(A) RNA binding [GO:0044822]; translation elongation factor activity [GO:0003746]; mitochondrial translation [GO:0032543]; mitochondrial translational elongation [GO:0070125]; organelle organization [GO:0006996]; translational elongation [GO:0006414]	mitochondrial translation [GO:0032543]; mitochondrial translational elongation [GO:0070125]; organelle organization [GO:0006996]; translational elongation [GO:0006414]	GTPase activity [GO:0003924]; GTP binding [GO:0005525]; poly(A) RNA binding [GO:0044822]; translation elongation factor activity [GO:0003746]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]	GO:0005525; GO:0003924; GO:0070062; GO:0016020; GO:0042645; GO:0032543; GO:0070125; GO:0005739; GO:0006996; GO:0044822; GO:0003746; GO:0006414	SUBCELLULAR LOCATION: Mitochondrion.	Acetylation; Complete proteome; Direct protein sequencing; Disease mutation; Elongation factor; GTP-binding; Mitochondrion; Nucleotide-binding; Protein biosynthesis; Reference proteome; Transit peptide	Chain (1); Domain (1); Erroneous initiation (3); Modified residue (4); Natural variant (1); Nucleotide binding (3); Region (5); Sequence conflict (3); Transit peptide (1)
TKT_HUMAN	P29401	TKT_HUMAN	reviewed	Transketolase (TK) (EC 2.2.1.1)	TKT	Homo sapiens (Human)	623	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; peroxisome [GO:0005777]; vesicle [GO:0031982]; cofactor binding [GO:0048037]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; transketolase activity [GO:0004802]; carbohydrate metabolic process [GO:0005975]; energy reserve metabolic process [GO:0006112]; glyceraldehyde-3-phosphate biosynthetic process [GO:0046166]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, non-oxidative branch [GO:0009052]; regulation of growth [GO:0040008]; small molecule metabolic process [GO:0044281]; xylulose biosynthetic process [GO:0005999]	carbohydrate metabolic process [GO:0005975]; energy reserve metabolic process [GO:0006112]; glyceraldehyde-3-phosphate biosynthetic process [GO:0046166]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, non-oxidative branch [GO:0009052]; regulation of growth [GO:0040008]; small molecule metabolic process [GO:0044281]; xylulose biosynthetic process [GO:0005999]	cofactor binding [GO:0048037]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; transketolase activity [GO:0004802]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; peroxisome [GO:0005777]; vesicle [GO:0031982]	GO:0005975; GO:0048037; GO:0005829; GO:0006112; GO:0070062; GO:0046166; GO:0046872; GO:0005654; GO:0005634; GO:0006098; GO:0009052; GO:0005777; GO:0042803; GO:0040008; GO:0044281; GO:0004802; GO:0031982; GO:0005999		3D-structure; Acetylation; Alternative splicing; Calcium; Complete proteome; Direct protein sequencing; Magnesium; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Thiamine pyrophosphate; Transferase	Active site (1); Alternative sequence (1); Beta strand (21); Binding site (15); Chain (1); Helix (29); Metal binding (3); Modified residue (13); Natural variant (1); Nucleotide binding (1); Sequence conflict (7); Site (2); Turn (5)
PMF1_HUMAN	Q6P1K2	PMF1_HUMAN	reviewed	Polyamine-modulated factor 1 (PMF-1)	PMF1	Homo sapiens (Human)	205	cytosol [GO:0005829]; MIS12/MIND type complex [GO:0000444]; nucleus [GO:0005634]; transcription factor complex [GO:0005667]; leucine zipper domain binding [GO:0043522]; transcription coactivator activity [GO:0003713]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; regulation of transcription, DNA-templated [GO:0006355]; small GTPase mediated signal transduction [GO:0007264]; transcription from RNA polymerase II promoter [GO:0006366]	cell division [GO:0051301]; chromosome segregation [GO:0007059]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; regulation of transcription, DNA-templated [GO:0006355]; small GTPase mediated signal transduction [GO:0007264]; transcription from RNA polymerase II promoter [GO:0006366]	leucine zipper domain binding [GO:0043522]; transcription coactivator activity [GO:0003713]	cytosol [GO:0005829]; MIS12/MIND type complex [GO:0000444]; nucleus [GO:0005634]; transcription factor complex [GO:0005667]	GO:0000444; GO:0051301; GO:0007059; GO:0005829; GO:0043522; GO:0000278; GO:0007067; GO:0005634; GO:0006355; GO:0007264; GO:0003713; GO:0005667; GO:0006366	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16585270}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:16585270}. Note=Associated with the kinetochore.	Activator; Alternative splicing; Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition; Coiled coil; Complete proteome; Kinetochore; Mitosis; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation	Alternative sequence (6); Chain (1); Coiled coil (1); Erroneous initiation (2); Frameshift (1); Natural variant (2); Sequence conflict (1)
SRSF2_HUMAN	Q01130	SRSF2_HUMAN	reviewed	Serine/arginine-rich splicing factor 2 (Protein PR264) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2)	SRSF2 SFRS2	Homo sapiens (Human)	221	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; transcription corepressor activity [GO:0003714]; gene expression [GO:0010467]; mRNA 3'-end processing [GO:0031124]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of nucleic acid-templated transcription [GO:1903507]; RNA splicing [GO:0008380]; termination of RNA polymerase II transcription [GO:0006369]; transcription from RNA polymerase II promoter [GO:0006366]	gene expression [GO:0010467]; mRNA 3'-end processing [GO:0031124]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of nucleic acid-templated transcription [GO:1903507]; RNA splicing [GO:0008380]; termination of RNA polymerase II transcription [GO:0006369]; transcription from RNA polymerase II promoter [GO:0006366]	nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; transcription corepressor activity [GO:0003714]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]	GO:0008380; GO:0005737; GO:0070062; GO:0010467; GO:0031124; GO:0006406; GO:0006397; GO:0000398; GO:1903507; GO:0016607; GO:0005654; GO:0000166; GO:0005634; GO:0044822; GO:0005681; GO:0006369; GO:0003714; GO:0006366	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21157427}. Nucleus, nucleoplasm {ECO:0000269|PubMed:21157427}. Nucleus speckle {ECO:0000269|PubMed:21157427}. Note=Phosphorylation by SRPK2 provokes its redistribution from the nuclear specke to nucleoplasm.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein; RNA-binding; Reference proteome; mRNA processing; mRNA splicing	Alternative sequence (1); Beta strand (7); Chain (1); Compositional bias (2); Domain (1); Helix (3); Initiator methionine (1); Modified residue (13); Sequence conflict (1)
RS12_HUMAN	P25398	RS12_HUMAN	reviewed	40S ribosomal protein S12	RPS12	Homo sapiens (Human)	132	cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; membrane [GO:0016020]; poly(A) RNA binding [GO:0044822]; structural constituent of ribosome [GO:0003735]; cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	poly(A) RNA binding [GO:0044822]; structural constituent of ribosome [GO:0003735]	cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; membrane [GO:0016020]	GO:0006614; GO:0044267; GO:0005829; GO:0022627; GO:0010467; GO:0016020; GO:0000184; GO:0044822; GO:0003735; GO:0006412; GO:0006414; GO:0006413; GO:0006415; GO:0019058; GO:0016032; GO:0019083	SUBCELLULAR LOCATION: Cytoplasm.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Reference proteome; Ribonucleoprotein; Ribosomal protein	Chain (1); Initiator methionine (1); Modified residue (2); Sequence conflict (3)
F8VWK2_HUMAN	F8VWK2	F8VWK2_HUMAN	unreviewed	TRAF-type zinc finger domain-containing protein 1	TRAFD1	Homo sapiens (Human)	94							Complete proteome; Proteomics identification; Reference proteome	
SEP15_HUMAN	O60613	SEP15_HUMAN	reviewed	15 kDa selenoprotein	SEP15	Homo sapiens (Human)	162	endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; selenium binding [GO:0008430]; 'de novo' posttranslational protein folding [GO:0051084]	'de novo' posttranslational protein folding [GO:0051084]	selenium binding [GO:0008430]	endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]	GO:0051084; GO:0005788; GO:0070062; GO:0008430	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:11278576}. Note=The association with UGGT1/UGCGL1 is essential for its retention in the endoplasmic reticulum.	Alternative splicing; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Reference proteome; Selenocysteine; Signal	Alternative sequence (2); Chain (1); Erroneous initiation (3); Mass spectrometry (2); Non-standard residue (1); Signal peptide (1)
UBP15_HUMAN	Q9Y4E8	UBP15_HUMAN	reviewed	Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.4.19.12) (Deubiquitinating enzyme 15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) (Unph-2) (Unph4)	USP15 KIAA0529	Homo sapiens (Human)	981	cytoplasm [GO:0005737]; nucleus [GO:0005634]; cysteine-type endopeptidase activity [GO:0004197]; identical protein binding [GO:0042802]; SMAD binding [GO:0046332]; transforming growth factor beta receptor binding [GO:0005160]; ubiquitin-specific protease activity [GO:0004843]; ubiquitinated histone binding [GO:0061649]; BMP signaling pathway [GO:0030509]; histone H2B conserved C-terminal lysine deubiquitination [GO:0035616]; monoubiquitinated protein deubiquitination [GO:0035520]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; pathway-restricted SMAD protein phosphorylation [GO:0060389]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; regulation of proteasomal protein catabolic process [GO:0061136]; transforming growth factor beta receptor signaling pathway [GO:0007179]	BMP signaling pathway [GO:0030509]; histone H2B conserved C-terminal lysine deubiquitination [GO:0035616]; monoubiquitinated protein deubiquitination [GO:0035520]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; pathway-restricted SMAD protein phosphorylation [GO:0060389]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; regulation of proteasomal protein catabolic process [GO:0061136]; transforming growth factor beta receptor signaling pathway [GO:0007179]	cysteine-type endopeptidase activity [GO:0004197]; identical protein binding [GO:0042802]; SMAD binding [GO:0046332]; transforming growth factor beta receptor binding [GO:0005160]; ubiquitinated histone binding [GO:0061649]; ubiquitin-specific protease activity [GO:0004843]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0030509; GO:0046332; GO:0004197; GO:0005737; GO:0035616; GO:0042802; GO:0035520; GO:0030512; GO:0005634; GO:0060389; GO:0043161; GO:0016579; GO:0061136; GO:0005160; GO:0007179; GO:0004843; GO:0061649	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21947082, ECO:0000269|PubMed:24526689}. Nucleus {ECO:0000269|PubMed:21947082, ECO:0000269|PubMed:24526689}.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Nucleus; Phosphoprotein; Protease; Reference proteome; Thiol protease; Ubl conjugation; Ubl conjugation pathway	Active site (2); Alternative sequence (4); Beta strand (12); Chain (1); Domain (2); Helix (7); Initiator methionine (1); Modified residue (5); Mutagenesis (2); Region (1); Sequence conflict (3); Turn (3)
BIN2_HUMAN	Q9UBW5	BIN2_HUMAN	reviewed	Bridging integrator 2 (Breast cancer-associated protein 1)	BIN2 BRAP1	Homo sapiens (Human)	565	cell cortex [GO:0005938]; cell junction [GO:0030054]; cell projection [GO:0042995]; phagocytic cup [GO:0001891]; podosome [GO:0002102]; phospholipid binding [GO:0005543]; cell chemotaxis [GO:0060326]; membrane tubulation [GO:0097320]; phagocytosis, engulfment [GO:0006911]; podosome assembly [GO:0071800]	cell chemotaxis [GO:0060326]; membrane tubulation [GO:0097320]; phagocytosis, engulfment [GO:0006911]; podosome assembly [GO:0071800]	phospholipid binding [GO:0005543]	cell cortex [GO:0005938]; cell junction [GO:0030054]; cell projection [GO:0042995]; phagocytic cup [GO:0001891]; podosome [GO:0002102]	GO:0060326; GO:0005938; GO:0030054; GO:0042995; GO:0097320; GO:0001891; GO:0006911; GO:0005543; GO:0002102; GO:0071800	SUBCELLULAR LOCATION: Cytoplasm. Cell projection, podosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cell projection, phagocytic cup. Note=Associates with membranes enriched in phosphoinositides. Detected in the actin-rich cell cortex at the leading edge of migrating cells. Detected at podosomes, at an actin-rich ring-like structure.	3D-structure; Alternative splicing; Cell junction; Cell membrane; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Membrane; Phosphoprotein; Polymorphism; Reference proteome	Alternative sequence (1); Beta strand (1); Chain (1); Coiled coil (1); Compositional bias (2); Domain (1); Erroneous initiation (1); Frameshift (1); Helix (7); Modified residue (9); Mutagenesis (4); Natural variant (2); Sequence conflict (1)
PDIA4_HUMAN	P13667	PDIA4_HUMAN	reviewed	Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72)	PDIA4 ERP70 ERP72	Homo sapiens (Human)	645	cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; melanosome [GO:0042470]; poly(A) RNA binding [GO:0044822]; protein disulfide isomerase activity [GO:0003756]; cell redox homeostasis [GO:0045454]; chaperone-mediated protein folding [GO:0061077]; protein folding [GO:0006457]; protein secretion [GO:0009306]; response to endoplasmic reticulum stress [GO:0034976]	cell redox homeostasis [GO:0045454]; chaperone-mediated protein folding [GO:0061077]; protein folding [GO:0006457]; protein secretion [GO:0009306]; response to endoplasmic reticulum stress [GO:0034976]	poly(A) RNA binding [GO:0044822]; protein disulfide isomerase activity [GO:0003756]	cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; melanosome [GO:0042470]	GO:0045454; GO:0009986; GO:0061077; GO:0005788; GO:0042470; GO:0044822; GO:0003756; GO:0006457; GO:0009306; GO:0034976	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.	3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Disulfide bond; Endoplasmic reticulum; Isomerase; Polymorphism; Redox-active center; Reference proteome; Repeat; Signal	Beta strand (13); Chain (1); Compositional bias (1); Disulfide bond (3); Domain (3); Helix (9); Modified residue (1); Motif (1); Natural variant (1); Sequence conflict (1); Signal peptide (1); Turn (4)
PHOCN_HUMAN	Q9Y3A3	PHOCN_HUMAN	reviewed	MOB-like protein phocein (2C4D) (Class II mMOB1) (Mob1 homolog 3) (Mob3) (Mps one binder kinase activator-like 3) (Preimplantation protein 3)	MOB4 MOB3 MOBKL3 PHOCN PREI3 CGI-95	Homo sapiens (Human)	225	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; metal ion binding [GO:0046872]; transport [GO:0006810]	transport [GO:0006810]	metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]	GO:0005794; GO:0032580; GO:0005737; GO:0005829; GO:0043197; GO:0046872; GO:0043025; GO:0048471; GO:0006810	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:11319234}. Membrane {ECO:0000269|PubMed:11319234}; Peripheral membrane protein {ECO:0000269|PubMed:11319234}. Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:11319234}; Peripheral membrane protein {ECO:0000269|PubMed:11319234}. Note=In a perinuclear punctate pattern. Associated with membranes and the Golgi stacks.	Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Golgi apparatus; Membrane; Metal-binding; Phosphoprotein; Reference proteome; Transport; Zinc	Alternative sequence (2); Chain (1); Erroneous initiation (1); Frameshift (1); Metal binding (4); Sequence conflict (3)
H3BPN5_HUMAN	H3BPN5	H3BPN5_HUMAN	unreviewed	Serine/threonine-protein phosphatase 4 catalytic subunit	PPP4C	Homo sapiens (Human)	50							Complete proteome; Proteomics identification; Reference proteome	
D6RFG8_HUMAN	D6RFG8	D6RFG8_HUMAN	unreviewed	Deoxycytidine kinase	DCK	Homo sapiens (Human)	317	nucleus [GO:0005634]; ATP binding [GO:0005524]; nucleoside kinase activity [GO:0019206]		ATP binding [GO:0005524]; nucleoside kinase activity [GO:0019206]	nucleus [GO:0005634]	GO:0005524; GO:0019206; GO:0005634		Complete proteome; Proteomics identification; Reference proteome	
DCK_HUMAN	P27707	DCK_HUMAN	reviewed	Deoxycytidine kinase (dCK) (EC 2.7.1.74)	DCK	Homo sapiens (Human)	260	cytosol [GO:0005829]; nucleus [GO:0005634]; ATP binding [GO:0005524]; deoxycytidine kinase activity [GO:0004137]; drug binding [GO:0008144]; nucleoside kinase activity [GO:0019206]; protein homodimerization activity [GO:0042803]; deoxyribonucleoside monophosphate biosynthetic process [GO:0009157]; nucleobase-containing small molecule metabolic process [GO:0055086]; nucleotide biosynthetic process [GO:0009165]; purine nucleobase metabolic process [GO:0006144]; purine-containing compound salvage [GO:0043101]; pyrimidine nucleobase metabolic process [GO:0006206]; pyrimidine nucleoside salvage [GO:0043097]; pyrimidine nucleotide metabolic process [GO:0006220]; small molecule metabolic process [GO:0044281]	deoxyribonucleoside monophosphate biosynthetic process [GO:0009157]; nucleobase-containing small molecule metabolic process [GO:0055086]; nucleotide biosynthetic process [GO:0009165]; purine-containing compound salvage [GO:0043101]; purine nucleobase metabolic process [GO:0006144]; pyrimidine nucleobase metabolic process [GO:0006206]; pyrimidine nucleoside salvage [GO:0043097]; pyrimidine nucleotide metabolic process [GO:0006220]; small molecule metabolic process [GO:0044281]	ATP binding [GO:0005524]; deoxycytidine kinase activity [GO:0004137]; drug binding [GO:0008144]; nucleoside kinase activity [GO:0019206]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0005524; GO:0005829; GO:0004137; GO:0009157; GO:0008144; GO:0055086; GO:0019206; GO:0009165; GO:0005634; GO:0042803; GO:0006144; GO:0043101; GO:0006206; GO:0043097; GO:0006220; GO:0044281	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9342341}.	3D-structure; ATP-binding; Complete proteome; Direct protein sequencing; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Transferase	Active site (1); Beta strand (7); Binding site (6); Chain (1); Helix (16); Modified residue (4); Mutagenesis (4); Nucleotide binding (3); Sequence conflict (2); Turn (1)
GALE_HUMAN	Q14376	GALE_HUMAN	reviewed	UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-N-acetylgalactosamine 4-epimerase) (UDP-GalNAc 4-epimerase) (UDP-N-acetylglucosamine 4-epimerase) (UDP-GlcNAc 4-epimerase) (EC 5.1.3.7) (UDP-galactose 4-epimerase)	GALE	Homo sapiens (Human)	348	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; coenzyme binding [GO:0050662]; protein homodimerization activity [GO:0042803]; UDP-glucose 4-epimerase activity [GO:0003978]; UDP-N-acetylglucosamine 4-epimerase activity [GO:0003974]; carbohydrate metabolic process [GO:0005975]; galactose catabolic process [GO:0019388]; small molecule metabolic process [GO:0044281]	carbohydrate metabolic process [GO:0005975]; galactose catabolic process [GO:0019388]; small molecule metabolic process [GO:0044281]	coenzyme binding [GO:0050662]; protein homodimerization activity [GO:0042803]; UDP-glucose 4-epimerase activity [GO:0003978]; UDP-N-acetylglucosamine 4-epimerase activity [GO:0003974]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0003974; GO:0003978; GO:0005975; GO:0050662; GO:0005829; GO:0070062; GO:0019388; GO:0042803; GO:0044281		3D-structure; Alternative splicing; Carbohydrate metabolism; Complete proteome; Disease mutation; Galactose metabolism; Isomerase; NAD; Polymorphism; Reference proteome	Active site (1); Alternative sequence (1); Beta strand (19); Binding site (5); Chain (1); Erroneous gene model prediction (7); Helix (12); Mutagenesis (3); Natural variant (17); Nucleotide binding (3); Region (5); Sequence conflict (1); Turn (2)
TIM8B_HUMAN	Q9Y5J9	TIM8B_HUMAN	reviewed	Mitochondrial import inner membrane translocase subunit Tim8 B (DDP-like protein) (Deafness dystonia protein 2)	TIMM8B DDP2 DDPL TIM8B	Homo sapiens (Human)	83	extracellular space [GO:0005615]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space protein transporter complex [GO:0042719]; zinc ion binding [GO:0008270]; cellular protein metabolic process [GO:0044267]; chaperone-mediated protein transport [GO:0072321]; protein targeting to mitochondrion [GO:0006626]; sensory perception of sound [GO:0007605]	cellular protein metabolic process [GO:0044267]; chaperone-mediated protein transport [GO:0072321]; protein targeting to mitochondrion [GO:0006626]; sensory perception of sound [GO:0007605]	zinc ion binding [GO:0008270]	extracellular space [GO:0005615]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space protein transporter complex [GO:0042719]	GO:0044267; GO:0072321; GO:0005615; GO:0005743; GO:0042719; GO:0006626; GO:0007605; GO:0008270	SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Intermembrane side {ECO:0000250}.	Acetylation; Chaperone; Complete proteome; Disulfide bond; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Protein transport; Reference proteome; Translocation; Transport; Zinc	Chain (1); Disulfide bond (2); Initiator methionine (1); Modified residue (1); Motif (1)
E9PIR3_HUMAN	E9PIR3	E9PIR3_HUMAN	unreviewed	Mitochondrial import inner membrane translocase subunit Tim8 B	TIMM8B	Homo sapiens (Human)	32							Complete proteome; Proteomics identification; Reference proteome	
DYHC1_HUMAN	Q14204	DYHC1_HUMAN	reviewed	Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic)	DYNC1H1 DHC1 DNCH1 DNCL DNECL DYHC KIAA0325	Homo sapiens (Human)	4646	centrosome [GO:0005813]; cytoplasmic dynein complex [GO:0005868]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; membrane [GO:0016020]; microtubule [GO:0005874]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; microtubule motor activity [GO:0003777]; poly(A) RNA binding [GO:0044822]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; cytoplasmic mRNA processing body assembly [GO:0033962]; establishment of spindle localization [GO:0051293]; G2/M transition of mitotic cell cycle [GO:0000086]; microtubule-based movement [GO:0007018]; mitotic cell cycle [GO:0000278]; mitotic spindle organization [GO:0007052]; organelle organization [GO:0006996]; stress granule assembly [GO:0034063]; transport [GO:0006810]	antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; cytoplasmic mRNA processing body assembly [GO:0033962]; establishment of spindle localization [GO:0051293]; G2/M transition of mitotic cell cycle [GO:0000086]; microtubule-based movement [GO:0007018]; mitotic cell cycle [GO:0000278]; mitotic spindle organization [GO:0007052]; organelle organization [GO:0006996]; stress granule assembly [GO:0034063]; transport [GO:0006810]	ATPase activity [GO:0016887]; ATP binding [GO:0005524]; microtubule motor activity [GO:0003777]; poly(A) RNA binding [GO:0044822]	centrosome [GO:0005813]; cytoplasmic dynein complex [GO:0005868]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; membrane [GO:0016020]; microtubule [GO:0005874]	GO:0005524; GO:0016887; GO:0000086; GO:0019886; GO:0005813; GO:0005868; GO:0033962; GO:0005829; GO:0051293; GO:0070062; GO:0030175; GO:0016020; GO:0005874; GO:0003777; GO:0007018; GO:0000278; GO:0007052; GO:0006996; GO:0044822; GO:0034063; GO:0006810	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.	3D-structure; ATP-binding; Acetylation; Charcot-Marie-Tooth disease; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Disease mutation; Dynein; Mental retardation; Microtubule; Motor protein; Neurodegeneration; Neuropathy; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transport	Chain (1); Coiled coil (8); Erroneous initiation (1); Initiator methionine (1); Modified residue (5); Natural variant (29); Nucleotide binding (4); Region (10); Sequence conflict (3)
ABI1_HUMAN	Q8IZP0	ABI1_HUMAN	reviewed	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1)	ABI1 SSH3BP1	Homo sapiens (Human)	508	cell junction [GO:0030054]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; growth cone [GO:0030426]; intracellular [GO:0005622]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; SCAR complex [GO:0031209]; cytoskeletal protein binding [GO:0008092]; protein complex binding [GO:0032403]; protein tyrosine kinase activator activity [GO:0030296]; actin polymerization or depolymerization [GO:0008154]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; innate immune response [GO:0045087]; lamellipodium morphogenesis [GO:0072673]; megakaryocyte development [GO:0035855]; movement of cell or subcellular component [GO:0006928]; negative regulation of cell proliferation [GO:0008285]; peptidyl-tyrosine phosphorylation [GO:0018108]; small GTPase mediated signal transduction [GO:0007264]; somitogenesis [GO:0001756]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; viral process [GO:0016032]	actin polymerization or depolymerization [GO:0008154]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; innate immune response [GO:0045087]; lamellipodium morphogenesis [GO:0072673]; megakaryocyte development [GO:0035855]; movement of cell or subcellular component [GO:0006928]; negative regulation of cell proliferation [GO:0008285]; peptidyl-tyrosine phosphorylation [GO:0018108]; small GTPase mediated signal transduction [GO:0007264]; somitogenesis [GO:0001756]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; viral process [GO:0016032]	cytoskeletal protein binding [GO:0008092]; protein complex binding [GO:0032403]; protein tyrosine kinase activator activity [GO:0030296]	cell junction [GO:0030054]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; growth cone [GO:0030426]; intracellular [GO:0005622]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; SCAR complex [GO:0031209]	GO:0038096; GO:0031209; GO:0008154; GO:0030054; GO:0008092; GO:0005856; GO:0005829; GO:0005783; GO:0070062; GO:0030175; GO:0030426; GO:0045087; GO:0005622; GO:0030027; GO:0072673; GO:0035855; GO:0006928; GO:0008285; GO:0005634; GO:0018108; GO:0014069; GO:0045211; GO:0032403; GO:0030296; GO:0007264; GO:0001756; GO:0007169; GO:0048010; GO:0016032	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localized to protruding lamellipodia and filopodia tips. Also localized to neuronal growth cones and synaptosomes. May shuttle from the postsynaptic densities to the nucleus (By similarity). {ECO:0000250}.	Acetylation; Alternative splicing; Cell junction; Cell membrane; Cell projection; Chromosomal rearrangement; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Host-virus interaction; Membrane; Nucleus; Phosphoprotein; Polymorphism; Postsynaptic cell membrane; Reference proteome; SH3 domain; Synapse	Alternative sequence (9); Chain (1); Compositional bias (1); Domain (2); Initiator methionine (1); Modified residue (13); Natural variant (1); Region (1); Sequence conflict (4); Site (1)
F5H1G9_HUMAN	F5H1G9	F5H1G9_HUMAN		Merged into B6VEX4.											
ABI3_HUMAN	Q9P2A4	ABI3_HUMAN	reviewed	ABI gene family member 3 (New molecule including SH3) (Nesh)	ABI3 NESH	Homo sapiens (Human)	366	cytoplasm [GO:0005737]; intracellular [GO:0005622]; lamellipodium [GO:0030027]; membrane [GO:0016020]; movement of cell or subcellular component [GO:0006928]; regulation of cell migration [GO:0030334]	movement of cell or subcellular component [GO:0006928]; regulation of cell migration [GO:0030334]		cytoplasm [GO:0005737]; intracellular [GO:0005622]; lamellipodium [GO:0030027]; membrane [GO:0016020]	GO:0005737; GO:0005622; GO:0030027; GO:0016020; GO:0006928; GO:0030334	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11956071}. Note=Colocalizes with PAK2 at leading edge of cells.	Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Phosphoprotein; Polymorphism; Reference proteome; SH3 domain	Alternative sequence (1); Chain (1); Coiled coil (1); Compositional bias (1); Domain (1); Modified residue (3); Natural variant (3)
UBXN1_HUMAN	Q04323	UBXN1_HUMAN	reviewed	UBX domain-containing protein 1 (SAPK substrate protein 1) (UBA/UBX 33.3 kDa protein)	UBXN1 SAKS1	Homo sapiens (Human)	297	cytoplasm [GO:0005737]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098]; ATPase binding [GO:0051117]; K6-linked polyubiquitin binding [GO:0071796]; polyubiquitin binding [GO:0031593]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein ubiquitination [GO:0031397]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein ubiquitination [GO:0031397]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	ATPase binding [GO:0051117]; K6-linked polyubiquitin binding [GO:0071796]; polyubiquitin binding [GO:0031593]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098]	GO:0051117; GO:0071796; GO:0034098; GO:0005737; GO:0030425; GO:0032435; GO:0031397; GO:0043025; GO:0005634; GO:0031593; GO:0043161; GO:0043130; GO:0031625	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.	Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Phosphoprotein; Polymorphism; Reference proteome	Alternative sequence (1); Chain (1); Coiled coil (1); Domain (2); Initiator methionine (1); Modified residue (5); Mutagenesis (2); Natural variant (1); Region (1); Sequence conflict (3)
E9PFF5_HUMAN	E9PFF5	E9PFF5_HUMAN	unreviewed	Fragile X mental retardation syndrome-related protein 1	FXR1	Homo sapiens (Human)	490	cytoplasm [GO:0005737]; nucleus [GO:0005634]; mRNA binding [GO:0003729]; negative regulation of translation [GO:0017148]	negative regulation of translation [GO:0017148]	mRNA binding [GO:0003729]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005737; GO:0003729; GO:0017148; GO:0005634		Complete proteome; Proteomics identification; Reference proteome	
FXR1_HUMAN	P51114	FXR1_HUMAN	reviewed	Fragile X mental retardation syndrome-related protein 1 (hFXR1p)	FXR1	Homo sapiens (Human)	621	costamere [GO:0043034]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; polysome [GO:0005844]; G-quadruplex RNA binding [GO:0002151]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; muscle organ development [GO:0007517]; negative regulation of translation [GO:0017148]	apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; muscle organ development [GO:0007517]; negative regulation of translation [GO:0017148]	G-quadruplex RNA binding [GO:0002151]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]	costamere [GO:0043034]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; polysome [GO:0005844]	GO:0002151; GO:0003723; GO:0006915; GO:0030154; GO:0043034; GO:0005737; GO:0003730; GO:0003729; GO:0016020; GO:0007517; GO:0017148; GO:0005730; GO:0005634; GO:0044822; GO:0005844	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:7781595}.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Direct protein sequencing; Myogenesis; Phosphoprotein; Polymorphism; RNA-binding; Reference proteome; Repeat	Alternative sequence (3); Beta strand (13); Chain (1); Compositional bias (2); Domain (4); Helix (5); Initiator methionine (1); Modified residue (9); Natural variant (3); Region (1); Sequence conflict (2); Turn (1)
LA_HUMAN	P05455	LA_HUMAN	reviewed	Lupus La protein (La autoantigen) (La ribonucleoprotein) (Sjoegren syndrome type B antigen) (SS-B)	SSB	Homo sapiens (Human)	408	nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]; mRNA binding [GO:0003729]; nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; tRNA binding [GO:0000049]; histone mRNA metabolic process [GO:0008334]; tRNA modification [GO:0006400]	histone mRNA metabolic process [GO:0008334]; tRNA modification [GO:0006400]	mRNA binding [GO:0003729]; nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; tRNA binding [GO:0000049]	nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]	GO:0008334; GO:0003729; GO:0000166; GO:0005634; GO:0044822; GO:0030529; GO:0000049; GO:0006400	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.	3D-structure; Acetylation; Complete proteome; Nucleus; Phosphoprotein; Polymorphism; RNA-binding; Reference proteome; Systemic lupus erythematosus	Beta strand (13); Chain (1); Domain (2); Helix (13); Modified residue (7); Natural variant (1); Sequence conflict (1); Turn (4)
ECT2_HUMAN	Q9H8V3	ECT2_HUMAN	reviewed	Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene)	ECT2	Homo sapiens (Human)	914	bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; centralspindlin complex [GO:0097149]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; GTPase activator activity [GO:0005096]; protein homodimerization activity [GO:0042803]; Rho guanyl-nucleotide exchange factor activity [GO:0005089]; signal transducer activity [GO:0004871]; activation of GTPase activity [GO:0090630]; activation of protein kinase activity [GO:0032147]; apoptotic signaling pathway [GO:0097190]; bicellular tight junction assembly [GO:0070830]; cell morphogenesis [GO:0000902]; cellular response to calcium ion [GO:0071277]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to ionizing radiation [GO:0071479]; cytokinesis [GO:0000910]; neurotrophin TRK receptor signaling pathway [GO:0048011]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cytokinesis [GO:0032467]; positive regulation of GTPase activity [GO:0043547]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of protein import into nucleus [GO:0042307]; protein homooligomerization [GO:0051260]; protein transport [GO:0015031]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of protein kinase activity [GO:0045859]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]	activation of GTPase activity [GO:0090630]; activation of protein kinase activity [GO:0032147]; apoptotic signaling pathway [GO:0097190]; bicellular tight junction assembly [GO:0070830]; cell morphogenesis [GO:0000902]; cellular response to calcium ion [GO:0071277]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to ionizing radiation [GO:0071479]; cytokinesis [GO:0000910]; neurotrophin TRK receptor signaling pathway [GO:0048011]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cytokinesis [GO:0032467]; positive regulation of GTPase activity [GO:0043547]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of protein import into nucleus [GO:0042307]; protein homooligomerization [GO:0051260]; protein transport [GO:0015031]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of protein kinase activity [GO:0045859]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]	GTPase activator activity [GO:0005096]; protein homodimerization activity [GO:0042803]; Rho guanyl-nucleotide exchange factor activity [GO:0005089]; signal transducer activity [GO:0004871]	bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; centralspindlin complex [GO:0097149]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]	GO:0005096; GO:0005089; GO:0090630; GO:0032147; GO:0097190; GO:0005923; GO:0070830; GO:0000902; GO:0005911; GO:0071277; GO:0070301; GO:0071479; GO:0097149; GO:0032154; GO:0000910; GO:0005737; GO:0005829; GO:0043231; GO:0030496; GO:0072686; GO:0048011; GO:0031965; GO:0005634; GO:0043547; GO:0043123; GO:0043065; GO:0032467; GO:0045666; GO:0042307; GO:0042803; GO:0051260; GO:0015031; GO:0051988; GO:0045859; GO:0051056; GO:0004871; GO:0007264	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Midbody. Cell junction. Cell junction, tight junction. Note=Sequestered within the nucleus during interphase. Dispersed throughout the cytoplasm upon breakdown of the nuclear envelope during mitosis. Colocalizes with the centralspindlin complex to the mitotic spindles during anaphase/metaphase, the cleavage furrow during telophase and at the midbody at the end of cytokinesis. Colocalized with RhoA at the midbody. Its subcellular localization to tight junction is increased by calcium. Localized predominantly in the cytoplasm of numerous carcinoma cells.	3D-structure; Acetylation; Alternative splicing; Cell cycle; Cell division; Cell junction; Complete proteome; Cytoplasm; Cytoskeleton; Differentiation; Guanine-nucleotide releasing factor; Neurogenesis; Nucleus; Oncogene; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Repeat; Tight junction; Transport	Alternative sequence (3); Beta strand (10); Chain (1); Domain (4); Erroneous initiation (1); Helix (12); Initiator methionine (1); Modified residue (9); Motif (2); Mutagenesis (12); Natural variant (2); Sequence conflict (3); Turn (5)
EIF3B_HUMAN	P55884	EIF3B_HUMAN	reviewed	Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (Prt1 homolog) (hPrt1) (eIF-3-eta) (eIF3 p110) (eIF3 p116)	EIF3B EIF3S9	Homo sapiens (Human)	814	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleotide binding [GO:0000166]; protein complex scaffold [GO:0032947]; translation initiation factor activity [GO:0003743]; cellular protein metabolic process [GO:0044267]; formation of translation preinitiation complex [GO:0001731]; gene expression [GO:0010467]; regulation of translational initiation [GO:0006446]; translation [GO:0006412]; translational initiation [GO:0006413]	cellular protein metabolic process [GO:0044267]; formation of translation preinitiation complex [GO:0001731]; gene expression [GO:0010467]; regulation of translational initiation [GO:0006446]; translation [GO:0006412]; translational initiation [GO:0006413]	nucleotide binding [GO:0000166]; protein complex scaffold [GO:0032947]; translation initiation factor activity [GO:0003743]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]	GO:0044267; GO:0005737; GO:0005829; GO:0016282; GO:0033290; GO:0005852; GO:0071541; GO:0070062; GO:0001731; GO:0010467; GO:0005654; GO:0000166; GO:0032947; GO:0006446; GO:0006412; GO:0003743; GO:0006413	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03001}.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Initiation factor; Phosphoprotein; Polymorphism; Protein biosynthesis; RNA-binding; Reference proteome; Repeat; WD repeat	Alternative sequence (1); Beta strand (6); Chain (1); Domain (1); Helix (2); Mass spectrometry (2); Modified residue (14); Natural variant (2); Region (2); Repeat (8); Sequence conflict (1); Turn (1)
EXOS3_HUMAN	Q9NQT5	EXOS3_HUMAN	reviewed	Exosome complex component RRP40 (Exosome component 3) (Ribosomal RNA-processing protein 40) (p10)	EXOSC3 RRP40 CGI-102	Homo sapiens (Human)	275	cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; exosome (RNase complex) [GO:0000178]; nuclear exosome (RNase complex) [GO:0000176]; nucleolus [GO:0005730]; nucleus [GO:0005634]; transcriptionally active chromatin [GO:0035327]; 3'-5'-exoribonuclease activity [GO:0000175]; RNA binding [GO:0003723]; CUT catabolic process [GO:0071034]; DNA deamination [GO:0045006]; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [GO:0043928]; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; gene expression [GO:0010467]; isotype switching [GO:0045190]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; nuclear polyadenylation-dependent tRNA catabolic process [GO:0071038]; nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription [GO:0071049]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; polyadenylation-dependent snoRNA 3'-end processing [GO:0071051]; positive regulation of isotype switching [GO:0045830]; rRNA processing [GO:0006364]; U4 snRNA 3'-end processing [GO:0034475]	CUT catabolic process [GO:0071034]; DNA deamination [GO:0045006]; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [GO:0043928]; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; gene expression [GO:0010467]; isotype switching [GO:0045190]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; nuclear polyadenylation-dependent tRNA catabolic process [GO:0071038]; nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription [GO:0071049]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; polyadenylation-dependent snoRNA 3'-end processing [GO:0071051]; positive regulation of isotype switching [GO:0045830]; rRNA processing [GO:0006364]; U4 snRNA 3'-end processing [GO:0034475]	3'-5'-exoribonuclease activity [GO:0000175]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; exosome (RNase complex) [GO:0000178]; nuclear exosome (RNase complex) [GO:0000176]; nucleolus [GO:0005730]; nucleus [GO:0005634]; transcriptionally active chromatin [GO:0035327]	GO:0000175; GO:0071034; GO:0045006; GO:0003723; GO:0034475; GO:0005737; GO:0000177; GO:0005829; GO:0043928; GO:0000467; GO:0000178; GO:0010467; GO:0045190; GO:0000176; GO:0071035; GO:0071038; GO:0071049; GO:0000288; GO:0034427; GO:0005730; GO:0005634; GO:0071051; GO:0045830; GO:0006364; GO:0035327	SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleolus. Nucleus.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Exosome; Neurodegeneration; Nucleus; Polymorphism; RNA-binding; Reference proteome; rRNA processing	Alternative sequence (1); Beta strand (18); Chain (1); Helix (5); Initiator methionine (1); Modified residue (1); Natural variant (5); Sequence conflict (2); Turn (4)
ZCCHL_HUMAN	Q96H79	ZCCHL_HUMAN	reviewed	Zinc finger CCCH-type antiviral protein 1-like	ZC3HAV1L C7orf39	Homo sapiens (Human)	300							Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Reference proteome	Alternative sequence (2); Chain (1); Initiator methionine (1); Modified residue (1); Sequence conflict (1)
F2Z2Q9_HUMAN	F2Z2Q9	F2Z2Q9_HUMAN	unreviewed	Low molecular weight phosphotyrosine protein phosphatase	ACP1	Homo sapiens (Human)	70	protein tyrosine phosphatase activity [GO:0004725]		protein tyrosine phosphatase activity [GO:0004725]		GO:0004725		Complete proteome; Proteomics identification; Reference proteome	
G5E9R5_HUMAN	G5E9R5	G5E9R5_HUMAN	unreviewed	Acid phosphatase 1, soluble, isoform CRA_d (Low molecular weight phosphotyrosine protein phosphatase)	ACP1 hCG_1784797	Homo sapiens (Human)	80	protein tyrosine phosphatase activity [GO:0004725]		protein tyrosine phosphatase activity [GO:0004725]		GO:0004725		Complete proteome; Proteomics identification; Reference proteome	
G6PD_HUMAN	P11413	G6PD_HUMAN	reviewed	Glucose-6-phosphate 1-dehydrogenase (G6PD) (EC 1.1.1.49)	G6PD	Homo sapiens (Human)	515	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; glucose binding [GO:0005536]; glucose-6-phosphate dehydrogenase activity [GO:0004345]; identical protein binding [GO:0042802]; NADP binding [GO:0050661]; protein homodimerization activity [GO:0042803]; carbohydrate metabolic process [GO:0005975]; cellular response to oxidative stress [GO:0034599]; cholesterol biosynthetic process [GO:0006695]; cytokine production [GO:0001816]; erythrocyte maturation [GO:0043249]; gene expression [GO:0010467]; glucose 6-phosphate metabolic process [GO:0051156]; glucose metabolic process [GO:0006006]; glutathione metabolic process [GO:0006749]; lipid metabolic process [GO:0006629]; NADP metabolic process [GO:0006739]; NADPH regeneration [GO:0006740]; negative regulation of protein glutathionylation [GO:0010734]; oxidation-reduction process [GO:0055114]; pentose biosynthetic process [GO:0019322]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, oxidative branch [GO:0009051]; regulation of neuron apoptotic process [GO:0043523]; response to ethanol [GO:0045471]; response to food [GO:0032094]; response to organic cyclic compound [GO:0014070]; ribose phosphate biosynthetic process [GO:0046390]; small molecule metabolic process [GO:0044281]; substantia nigra development [GO:0021762]; transcription initiation from RNA polymerase II promoter [GO:0006367]	carbohydrate metabolic process [GO:0005975]; cellular response to oxidative stress [GO:0034599]; cholesterol biosynthetic process [GO:0006695]; cytokine production [GO:0001816]; erythrocyte maturation [GO:0043249]; gene expression [GO:0010467]; glucose 6-phosphate metabolic process [GO:0051156]; glucose metabolic process [GO:0006006]; glutathione metabolic process [GO:0006749]; lipid metabolic process [GO:0006629]; NADPH regeneration [GO:0006740]; NADP metabolic process [GO:0006739]; negative regulation of protein glutathionylation [GO:0010734]; oxidation-reduction process [GO:0055114]; pentose biosynthetic process [GO:0019322]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, oxidative branch [GO:0009051]; regulation of neuron apoptotic process [GO:0043523]; response to ethanol [GO:0045471]; response to food [GO:0032094]; response to organic cyclic compound [GO:0014070]; ribose phosphate biosynthetic process [GO:0046390]; small molecule metabolic process [GO:0044281]; substantia nigra development [GO:0021762]; transcription initiation from RNA polymerase II promoter [GO:0006367]	glucose-6-phosphate dehydrogenase activity [GO:0004345]; glucose binding [GO:0005536]; identical protein binding [GO:0042802]; NADP binding [GO:0050661]; protein homodimerization activity [GO:0042803]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]	GO:0050661; GO:0006739; GO:0006740; GO:0005975; GO:0034599; GO:0005813; GO:0006695; GO:0001816; GO:0005737; GO:0009898; GO:0005829; GO:0043249; GO:0070062; GO:0010467; GO:0051156; GO:0005536; GO:0006006; GO:0004345; GO:0006749; GO:0042802; GO:0043231; GO:0006629; GO:0016020; GO:0005815; GO:0010734; GO:0005634; GO:0055114; GO:0019322; GO:0006098; GO:0009051; GO:0042803; GO:0043523; GO:0045471; GO:0032094; GO:0014070; GO:0046390; GO:0044281; GO:0021762; GO:0006367		3D-structure; Acetylation; Alternative splicing; Carbohydrate metabolism; Complete proteome; Direct protein sequencing; Disease mutation; Glucose metabolism; Hereditary hemolytic anemia; NADP; Oxidoreductase; Phosphoprotein; Polymorphism; Reference proteome	Active site (1); Alternative sequence (2); Beta strand (21); Binding site (16); Chain (1); Erroneous initiation (1); Helix (24); Initiator methionine (1); Modified residue (6); Mutagenesis (6); Natural variant (67); Nucleotide binding (3); Region (1); Sequence conflict (4); Turn (10)
DPOE3_HUMAN	Q9NRF9	DPOE3_HUMAN	reviewed	DNA polymerase epsilon subunit 3 (EC 2.7.7.7) (Arsenic-transactivated protein) (AsTP) (Chromatin accessibility complex 17 kDa protein) (CHRAC-17) (HuCHRAC17) (DNA polymerase II subunit 3) (DNA polymerase epsilon subunit p17)	POLE3 CHRAC17	Homo sapiens (Human)	147	Ada2/Gcn5/Ada3 transcription activator complex [GO:0005671]; epsilon DNA polymerase complex [GO:0008622]; nucleus [GO:0005634]; DNA-directed DNA polymerase activity [GO:0003887]; sequence-specific DNA binding [GO:0043565]; DNA biosynthetic process [GO:0071897]; DNA replication [GO:0006260]; histone H3 acetylation [GO:0043966]	DNA biosynthetic process [GO:0071897]; DNA replication [GO:0006260]; histone H3 acetylation [GO:0043966]	DNA-directed DNA polymerase activity [GO:0003887]; sequence-specific DNA binding [GO:0043565]	Ada2/Gcn5/Ada3 transcription activator complex [GO:0005671]; epsilon DNA polymerase complex [GO:0008622]; nucleus [GO:0005634]	GO:0005671; GO:0071897; GO:0006260; GO:0003887; GO:0008622; GO:0043966; GO:0005634; GO:0043565	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.	Acetylation; Coiled coil; Complete proteome; DNA-binding; DNA-directed DNA polymerase; Direct protein sequencing; Nucleotidyltransferase; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transferase	Chain (1); Coiled coil (1); Initiator methionine (1); Modified residue (3); Natural variant (3); Sequence conflict (4)
EDF1_HUMAN	O60869	EDF1_HUMAN	reviewed	Endothelial differentiation-related factor 1 (EDF-1) (Multiprotein-bridging factor 1) (MBF1)	EDF1	Homo sapiens (Human)	148	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intracellular [GO:0005622]; nucleolus [GO:0005730]; nucleus [GO:0005634]; poly(A) RNA binding [GO:0044822]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]; endothelial cell differentiation [GO:0045446]; multicellular organismal development [GO:0007275]; positive regulation of DNA binding [GO:0043388]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of lipid metabolic process [GO:0019216]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]	endothelial cell differentiation [GO:0045446]; multicellular organismal development [GO:0007275]; positive regulation of DNA binding [GO:0043388]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of lipid metabolic process [GO:0019216]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]	poly(A) RNA binding [GO:0044822]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intracellular [GO:0005622]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0005737; GO:0045446; GO:0070062; GO:0005622; GO:0007275; GO:0005730; GO:0005634; GO:0044822; GO:0043388; GO:0045893; GO:0019216; GO:0006355; GO:0043565; GO:0003713; GO:0006351	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Also nuclear upon binding to NR5A1 and treatment of cells with TPA or forskolin.	3D-structure; Acetylation; Activator; Alternative splicing; Calmodulin-binding; Complete proteome; Cytoplasm; DNA-binding; Developmental protein; Differentiation; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation	Alternative sequence (2); Beta strand (1); Chain (1); DNA binding (1); Domain (1); Erroneous gene model prediction (1); Helix (4); Initiator methionine (1); Modified residue (1); Motif (1); Mutagenesis (9); Region (2); Turn (2)
PARP1_HUMAN	P09874	PARP1_HUMAN	reviewed	Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1)	PARP1 ADPRT PPOL	Homo sapiens (Human)	1014	membrane [GO:0016020]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein complex [GO:0043234]; transcription factor complex [GO:0005667]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; NAD binding [GO:0051287]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; poly(A) RNA binding [GO:0044822]; protein kinase binding [GO:0019901]; protein N-terminus binding [GO:0047485]; transcription factor binding [GO:0008134]; zinc ion binding [GO:0008270]; base-excision repair [GO:0006284]; cellular protein metabolic process [GO:0044267]; cellular response to insulin stimulus [GO:0032869]; cellular response to oxidative stress [GO:0034599]; cellular response to superoxide [GO:0071451]; DNA damage response, detection of DNA damage [GO:0042769]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; gene expression [GO:0010467]; macrophage differentiation [GO:0030225]; mitochondrial DNA metabolic process [GO:0032042]; mitochondrial DNA repair [GO:0043504]; mitochondrion organization [GO:0007005]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of SMAD protein import into nucleus [GO:0060391]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; post-translational protein modification [GO:0043687]; protein ADP-ribosylation [GO:0006471]; protein autoprocessing [GO:0016540]; protein modification process [GO:0036211]; protein poly-ADP-ribosylation [GO:0070212]; protein sumoylation [GO:0016925]; regulation of growth rate [GO:0040009]; signal transduction involved in regulation of gene expression [GO:0023019]; telomere maintenance [GO:0000723]; transcription from RNA polymerase II promoter [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]; transcription, DNA-templated [GO:0006351]; transforming growth factor beta receptor signaling pathway [GO:0007179]	base-excision repair [GO:0006284]; cellular protein metabolic process [GO:0044267]; cellular response to insulin stimulus [GO:0032869]; cellular response to oxidative stress [GO:0034599]; cellular response to superoxide [GO:0071451]; DNA damage response, detection of DNA damage [GO:0042769]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; gene expression [GO:0010467]; macrophage differentiation [GO:0030225]; mitochondrial DNA metabolic process [GO:0032042]; mitochondrial DNA repair [GO:0043504]; mitochondrion organization [GO:0007005]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of SMAD protein import into nucleus [GO:0060391]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; post-translational protein modification [GO:0043687]; protein ADP-ribosylation [GO:0006471]; protein autoprocessing [GO:0016540]; protein modification process [GO:0036211]; protein poly-ADP-ribosylation [GO:0070212]; protein sumoylation [GO:0016925]; regulation of growth rate [GO:0040009]; signal transduction involved in regulation of gene expression [GO:0023019]; telomere maintenance [GO:0000723]; transcription, DNA-templated [GO:0006351]; transcription from RNA polymerase II promoter [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]; transforming growth factor beta receptor signaling pathway [GO:0007179]	DNA binding [GO:0003677]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD binding [GO:0051287]; poly(A) RNA binding [GO:0044822]; protein kinase binding [GO:0019901]; protein N-terminus binding [GO:0047485]; transcription factor binding [GO:0008134]; zinc ion binding [GO:0008270]	membrane [GO:0016020]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein complex [GO:0043234]; transcription factor complex [GO:0005667]	GO:0003677; GO:0042769; GO:0006281; GO:0051287; GO:0003950; GO:0006284; GO:0044267; GO:0032869; GO:0034599; GO:0071451; GO:0006302; GO:0019899; GO:0010467; GO:0042802; GO:0030225; GO:0016020; GO:0032042; GO:0043504; GO:0005739; GO:0007005; GO:0000122; GO:0005635; GO:0005730; GO:0005654; GO:0005634; GO:0044822; GO:0060391; GO:0045944; GO:2000679; GO:0043687; GO:0006471; GO:0047485; GO:0016540; GO:0043234; GO:0019901; GO:0036211; GO:0070212; GO:0016925; GO:0040009; GO:0023019; GO:0000723; GO:0008134; GO:0005667; GO:0006366; GO:0006367; GO:0006351; GO:0007179; GO:0008270	SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus. Note=Localizes at sites of DNA damage.	3D-structure; ADP-ribosylation; Acetylation; Complete proteome; DNA damage; DNA repair; DNA-binding; Direct protein sequencing; Glycosyltransferase; Metal-binding; NAD; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Transferase; Zinc; Zinc-finger	Beta strand (44); Chain (1); DNA binding (1); Domain (3); Helix (39); Initiator methionine (1); Modified residue (26); Motif (2); Mutagenesis (11); Natural variant (8); Region (1); Sequence conflict (7); Turn (11); Zinc finger (2)
TBL3_HUMAN	Q12788	TBL3_HUMAN	reviewed	Transducin beta-like protein 3 (WD repeat-containing protein SAZD)	TBL3 SAZD	Homo sapiens (Human)	808	nucleolus [GO:0005730]; nucleus [GO:0005634]; Pwp2p-containing subcomplex of 90S preribosome [GO:0034388]; small-subunit processome [GO:0032040]; poly(A) RNA binding [GO:0044822]; receptor signaling protein activity [GO:0005057]; snoRNA binding [GO:0030515]; G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger [GO:0007199]; intracellular signal transduction [GO:0035556]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger [GO:0007199]; intracellular signal transduction [GO:0035556]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]	poly(A) RNA binding [GO:0044822]; receptor signaling protein activity [GO:0005057]; snoRNA binding [GO:0030515]	nucleolus [GO:0005730]; nucleus [GO:0005634]; Pwp2p-containing subcomplex of 90S preribosome [GO:0034388]; small-subunit processome [GO:0032040]	GO:0007199; GO:0034388; GO:0035556; GO:0000462; GO:0005730; GO:0005634; GO:0044822; GO:0005057; GO:0032040; GO:0030515	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.	Acetylation; Complete proteome; Nucleus; Polymorphism; Reference proteome; Repeat; WD repeat	Chain (1); Erroneous initiation (1); Frameshift (1); Initiator methionine (1); Modified residue (1); Natural variant (3); Repeat (13); Sequence conflict (4)
SSRP1_HUMAN	Q08945	SSRP1_HUMAN	reviewed	FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160)	SSRP1 FACT80	Homo sapiens (Human)	709	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; poly(A) RNA binding [GO:0044822]; chromatin remodeling [GO:0006338]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; gene expression [GO:0010467]; positive regulation of viral transcription [GO:0050434]; regulation of transcription, DNA-templated [GO:0006355]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]; viral process [GO:0016032]	chromatin remodeling [GO:0006338]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; gene expression [GO:0010467]; positive regulation of viral transcription [GO:0050434]; regulation of transcription, DNA-templated [GO:0006355]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]; viral process [GO:0016032]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]; poly(A) RNA binding [GO:0044822]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003677; GO:0006281; GO:0006260; GO:0003682; GO:0006338; GO:0005694; GO:0005737; GO:0010467; GO:0005730; GO:0005654; GO:0005634; GO:0044822; GO:0050434; GO:0006355; GO:0006368; GO:0006366; GO:0016032	SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus. Chromosome. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci.	3D-structure; Acetylation; Chromosome; Complete proteome; DNA damage; DNA repair; DNA replication; DNA-binding; Direct protein sequencing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation; Ubl conjugation	Beta strand (17); Chain (1); Compositional bias (5); DNA binding (1); Helix (6); Initiator methionine (1); Modified residue (16); Mutagenesis (4); Natural variant (2); Sequence caution (1); Site (1)
PTAR1_HUMAN	Q7Z6K3	PTAR1_HUMAN	reviewed	Protein prenyltransferase alpha subunit repeat-containing protein 1	PTAR1	Homo sapiens (Human)	402	protein prenyltransferase activity [GO:0008318]; protein prenylation [GO:0018342]	protein prenylation [GO:0018342]	protein prenyltransferase activity [GO:0008318]		GO:0018342; GO:0008318		Acetylation; Complete proteome; Prenyltransferase; Reference proteome; Repeat; Transferase	Chain (1); Erroneous gene model prediction (1); Erroneous initiation (1); Initiator methionine (1); Modified residue (1); Repeat (5)
SNX3_HUMAN	O60493	SNX3_HUMAN	reviewed	Sorting nexin-3 (Protein SDP3)	SNX3	Homo sapiens (Human)	162	clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; early phagosome [GO:0032009]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extrinsic component of membrane [GO:0019898]; intracellular membrane-bounded organelle [GO:0043231]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; protein phosphatase binding [GO:0019903]; endocytosis [GO:0006897]; hemoglobin biosynthetic process [GO:0042541]; intralumenal vesicle formation [GO:0070676]; membrane invagination [GO:0010324]; negative regulation of early endosome to late endosome transport [GO:2000642]; negative regulation of phagocytosis [GO:0050765]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein transport [GO:0051224]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of neuron projection development [GO:0010976]; protein to membrane docking [GO:0022615]; regulation of cellular protein metabolic process [GO:0032268]; regulation of intracellular protein transport [GO:0033157]; regulation of Wnt signaling pathway [GO:0030111]; response to bacterium [GO:0009617]; transferrin transport [GO:0033572]	endocytosis [GO:0006897]; hemoglobin biosynthetic process [GO:0042541]; intralumenal vesicle formation [GO:0070676]; membrane invagination [GO:0010324]; negative regulation of early endosome to late endosome transport [GO:2000642]; negative regulation of phagocytosis [GO:0050765]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein transport [GO:0051224]; negative regulation of viral entry into host cell [GO:0046597]; positive regulation of neuron projection development [GO:0010976]; protein to membrane docking [GO:0022615]; regulation of cellular protein metabolic process [GO:0032268]; regulation of intracellular protein transport [GO:0033157]; regulation of Wnt signaling pathway [GO:0030111]; response to bacterium [GO:0009617]; transferrin transport [GO:0033572]	phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; protein phosphatase binding [GO:0019903]	clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; early phagosome [GO:0032009]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extrinsic component of membrane [GO:0019898]; intracellular membrane-bounded organelle [GO:0043231]	GO:0030136; GO:0005737; GO:0005829; GO:0005769; GO:0031901; GO:0032009; GO:0006897; GO:0010008; GO:0070062; GO:0019898; GO:0042541; GO:0043231; GO:0070676; GO:0010324; GO:2000642; GO:0050765; GO:0042177; GO:0051224; GO:0046597; GO:0080025; GO:0032266; GO:0070273; GO:0010314; GO:0010976; GO:0019903; GO:0022615; GO:0030111; GO:0032268; GO:0033157; GO:0009617; GO:0033572	SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:11433298, ECO:0000269|PubMed:21725319}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:23237080}. Note=Colocalizes to clathrin-coated endosomal vesicles morphologically distinct from retromer-decorated non-branched endosomal tubule structures (PubMed:21725319) Colocalizes with EEA1 on nascent phagosomes in dendritic cells but competes with EEA1 for binding to phagosomal membrane (PubMed:23237080). In the case of Salmonella enterica infection localizes to Salmonella-containing vacuoles (SCVs) from which SNX3-containing tubules form 30-60 min after infection (PubMed:20482551). {ECO:0000269|PubMed:20482551, ECO:0000269|PubMed:21725319, ECO:0000269|PubMed:23237080}.	3D-structure; Acetylation; Alternative splicing; Chromosomal rearrangement; Complete proteome; Cytoplasmic vesicle; Direct protein sequencing; Endosome; Lipid-binding; Microphthalmia; Phosphoprotein; Protein transport; Reference proteome; Transport; Ubl conjugation	Alternative sequence (3); Beta strand (3); Binding site (4); Chain (1); Domain (1); Helix (5); Initiator methionine (1); Modified residue (2); Mutagenesis (5); Region (1); Sequence conflict (2)
RUSD2_HUMAN	Q8IZ73	RUSD2_HUMAN	reviewed	RNA pseudouridylate synthase domain-containing protein 2	RPUSD2 C15orf19	Homo sapiens (Human)	545	poly(A) RNA binding [GO:0044822]; pseudouridine synthase activity [GO:0009982]; pseudouridine synthesis [GO:0001522]	pseudouridine synthesis [GO:0001522]	poly(A) RNA binding [GO:0044822]; pseudouridine synthase activity [GO:0009982]		GO:0044822; GO:0009982; GO:0001522		Alternative splicing; Complete proteome; Phosphoprotein; Reference proteome	Active site (1); Alternative sequence (1); Chain (1); Compositional bias (1); Frameshift (1); Modified residue (1); Sequence conflict (3)
DLRB1_HUMAN	Q9NP97	DLRB1_HUMAN	reviewed	Dynein light chain roadblock-type 1 (Bithoraxoid-like protein) (BLP) (Dynein light chain 2A, cytoplasmic) (Dynein-associated protein Km23) (Roadblock domain-containing protein 1)	DYNLRB1 BITH DNCL2A DNLC2A ROBLD1 HSPC162	Homo sapiens (Human)	96	centrosome [GO:0005813]; ciliary tip [GO:0097542]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; membrane [GO:0016020]; microtubule [GO:0005874]; primary cilium [GO:0072372]; microtubule motor activity [GO:0003777]; metabolic process [GO:0008152]; microtubule-based movement [GO:0007018]; organelle organization [GO:0006996]; transport [GO:0006810]; visual behavior [GO:0007632]	metabolic process [GO:0008152]; microtubule-based movement [GO:0007018]; organelle organization [GO:0006996]; transport [GO:0006810]; visual behavior [GO:0007632]	microtubule motor activity [GO:0003777]	centrosome [GO:0005813]; ciliary tip [GO:0097542]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; membrane [GO:0016020]; microtubule [GO:0005874]; primary cilium [GO:0072372]	GO:0005813; GO:0097542; GO:0005737; GO:0005868; GO:0016020; GO:0008152; GO:0005874; GO:0003777; GO:0007018; GO:0006996; GO:0072372; GO:0006810; GO:0007632	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Dynein; Microtubule; Motor protein; Polymorphism; Reference proteome; Transport	Alternative sequence (2); Beta strand (6); Chain (1); Helix (2); Initiator methionine (1); Modified residue (1); Natural variant (2)
K7EQJ5_HUMAN	K7EQJ5	K7EQJ5_HUMAN	unreviewed	40S ribosomal protein S15	RPS15	Homo sapiens (Human)	141	cytoplasm [GO:0005737]; small ribosomal subunit [GO:0015935]; structural constituent of ribosome [GO:0003735]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412]	ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412]	structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; small ribosomal subunit [GO:0015935]	GO:0005737; GO:0000028; GO:0015935; GO:0003735; GO:0006412		Complete proteome; Proteomics identification; Reference proteome	
FOXK1_HUMAN	P85037	FOXK1_HUMAN	reviewed	Forkhead box protein K1 (Myocyte nuclear factor) (MNF)	FOXK1 MNF	Homo sapiens (Human)	733	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding RNA polymerase II transcription factor activity [GO:0000981]; anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; muscle organ development [GO:0007517]; negative regulation of cell growth [GO:0030308]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription from RNA polymerase II promoter [GO:0006357]	anatomical structure morphogenesis [GO:0009653]; cell differentiation [GO:0030154]; muscle organ development [GO:0007517]; negative regulation of cell growth [GO:0030308]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription from RNA polymerase II promoter [GO:0006357]	RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding RNA polymerase II transcription factor activity [GO:0000981]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000977; GO:0009653; GO:0030154; GO:0007517; GO:0030308; GO:0045892; GO:0005730; GO:0005654; GO:0005634; GO:0045893; GO:0006357; GO:0000981	SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.	Acetylation; Activator; Alternative splicing; Complete proteome; DNA-binding; Developmental protein; Differentiation; Myogenesis; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation	Alternative sequence (2); Chain (1); Compositional bias (2); DNA binding (1); Domain (1); Initiator methionine (1); Modified residue (7); Sequence conflict (6)
GRP75_HUMAN	P38646	GRP75_HUMAN	reviewed	Stress-70 protein, mitochondrial (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Mortalin) (MOT) (Peptide-binding protein 74) (PBP74)	HSPA9 GRP75 HSPA9B mt-HSP70	Homo sapiens (Human)	679	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; ATP binding [GO:0005524]; poly(A) RNA binding [GO:0044822]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]; cellular protein metabolic process [GO:0044267]; negative regulation of apoptotic process [GO:0043066]; protein export from nucleus [GO:0006611]; protein folding [GO:0006457]; protein targeting to mitochondrion [GO:0006626]	cellular protein metabolic process [GO:0044267]; negative regulation of apoptotic process [GO:0043066]; protein export from nucleus [GO:0006611]; protein folding [GO:0006457]; protein targeting to mitochondrion [GO:0006626]	ATP binding [GO:0005524]; poly(A) RNA binding [GO:0044822]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]	GO:0005524; GO:0044267; GO:0005737; GO:0070062; GO:0005925; GO:0042645; GO:0005739; GO:0043066; GO:0005730; GO:0044822; GO:0006611; GO:0006457; GO:0006626; GO:0031625; GO:0051082	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:22002106}. Nucleus, nucleolus {ECO:0000269|PubMed:22002106}.	3D-structure; ATP-binding; Acetylation; Chaperone; Complete proteome; Direct protein sequencing; Mitochondrion; Nucleotide-binding; Nucleus; Polymorphism; Reference proteome; Transit peptide	Beta strand (24); Chain (1); Helix (19); Modified residue (23); Natural variant (4); Sequence conflict (8); Transit peptide (1); Turn (6)
EIF3E_HUMAN	P60228	EIF3E_HUMAN	reviewed	Eukaryotic translation initiation factor 3 subunit E (eIF3e) (Eukaryotic translation initiation factor 3 subunit 6) (Viral integration site protein INT-6 homolog) (eIF-3 p48)	EIF3E EIF3S6 INT6	Homo sapiens (Human)	445	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; poly(A) RNA binding [GO:0044822]; protein N-terminus binding [GO:0047485]; translation initiation factor activity [GO:0003743]; cellular protein metabolic process [GO:0044267]; formation of translation preinitiation complex [GO:0001731]; gene expression [GO:0010467]; negative regulation of translational initiation [GO:0045947]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of translational initiation [GO:0006446]; translation [GO:0006412]; translational initiation [GO:0006413]	cellular protein metabolic process [GO:0044267]; formation of translation preinitiation complex [GO:0001731]; gene expression [GO:0010467]; negative regulation of translational initiation [GO:0045947]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of translational initiation [GO:0006446]; translation [GO:0006412]; translational initiation [GO:0006413]	poly(A) RNA binding [GO:0044822]; protein N-terminus binding [GO:0047485]; translation initiation factor activity [GO:0003743]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	GO:0016605; GO:0044267; GO:0005737; GO:0005829; GO:0016282; GO:0033290; GO:0005852; GO:0070062; GO:0001731; GO:0010467; GO:0016020; GO:0045947; GO:0000184; GO:0005654; GO:0005634; GO:0044822; GO:0047485; GO:0006446; GO:0006412; GO:0003743; GO:0006413	SUBCELLULAR LOCATION: Cytoplasm. Nucleus, PML body.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Initiation factor; Nucleus; Phosphoprotein; Polymorphism; Protein biosynthesis; Reference proteome	Chain (1); Domain (1); Initiator methionine (1); Mass spectrometry (2); Modified residue (5); Mutagenesis (1); Natural variant (1); Region (3)
U2AF1_HUMAN	Q01081	U2AF1_HUMAN	reviewed	Splicing factor U2AF 35 kDa subunit (U2 auxiliary factor 35 kDa subunit) (U2 small nuclear RNA auxiliary factor 1) (U2 snRNP auxiliary factor small subunit)	U2AF1 U2AF35 U2AFBP FP793	Homo sapiens (Human)	240	Cajal body [GO:0015030]; catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; gene expression [GO:0010467]; mRNA 3'-end processing [GO:0031124]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of protein targeting to mitochondrion [GO:1903955]; regulation of mitochondrion degradation [GO:1903146]; RNA splicing [GO:0008380]; termination of RNA polymerase II transcription [GO:0006369]; transcription from RNA polymerase II promoter [GO:0006366]	gene expression [GO:0010467]; mRNA 3'-end processing [GO:0031124]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of protein targeting to mitochondrion [GO:1903955]; regulation of mitochondrion degradation [GO:1903146]; RNA splicing [GO:0008380]; termination of RNA polymerase II transcription [GO:0006369]; transcription from RNA polymerase II promoter [GO:0006366]	metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]	Cajal body [GO:0015030]; catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]	GO:0015030; GO:0008380; GO:0071013; GO:0010467; GO:0031124; GO:0006406; GO:0006397; GO:0000398; GO:0046872; GO:0016607; GO:0005654; GO:0000166; GO:0044822; GO:1903955; GO:1903146; GO:0005681; GO:0006369; GO:0006366	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15096518}. Nucleus speckle {ECO:0000269|PubMed:15096518}.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Metal-binding; Nucleus; Phosphoprotein; RNA-binding; Reference proteome; Repeat; Spliceosome; Zinc; Zinc-finger; mRNA processing; mRNA splicing	Alternative sequence (4); Beta strand (4); Chain (1); Compositional bias (2); Domain (1); Helix (2); Initiator methionine (1); Modified residue (2); Mutagenesis (1); Zinc finger (2)
FRG1_HUMAN	Q14331	FRG1_HUMAN	reviewed	Protein FRG1 (FSHD region gene 1 protein)	FRG1	Homo sapiens (Human)	258	Cajal body [GO:0015030]; catalytic step 2 spliceosome [GO:0071013]; nucleolus [GO:0005730]; Z disc [GO:0030018]; poly(A) RNA binding [GO:0044822]; mRNA splicing, via spliceosome [GO:0000398]; muscle organ development [GO:0007517]; rRNA processing [GO:0006364]	mRNA splicing, via spliceosome [GO:0000398]; muscle organ development [GO:0007517]; rRNA processing [GO:0006364]	poly(A) RNA binding [GO:0044822]	Cajal body [GO:0015030]; catalytic step 2 spliceosome [GO:0071013]; nucleolus [GO:0005730]; Z disc [GO:0030018]	GO:0015030; GO:0030018; GO:0071013; GO:0000398; GO:0007517; GO:0005730; GO:0044822; GO:0006364	SUBCELLULAR LOCATION: Nucleus, Cajal body. Nucleus, nucleolus. Cytoplasm. Cytoplasm, myofibril, sarcomere, Z line. Note=Localization changes during myogenesis from mainly cytoplasmic in undifferentiated myoblasts, to strongly nucleolar in early myotubes and back to cytoplasmic 5 days post-differentiation. Localized at the Z-line in the sarcomere of matured myotubes 8 days post-differentiation.	Actin-binding; Complete proteome; Cytoplasm; Myogenesis; Nucleus; Polymorphism; RNA-binding; Reference proteome; Ribosome biogenesis; Spliceosome; mRNA processing; mRNA splicing; rRNA processing	Chain (1); Compositional bias (1); Motif (2); Natural variant (2)
E7ENZ3_HUMAN	E7ENZ3	E7ENZ3_HUMAN	unreviewed	T-complex protein 1 subunit epsilon	CCT5	Homo sapiens (Human)	486	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; ATP binding [GO:0005524]; protein folding [GO:0006457]	protein folding [GO:0006457]	ATP binding [GO:0005524]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]	GO:0005524; GO:0005737; GO:0005730; GO:0006457		ATP-binding; Chaperone; Complete proteome; Nucleotide-binding; Proteomics identification; Reference proteome	
OLA1_HUMAN	Q9NTK5	OLA1_HUMAN	reviewed	Obg-like ATPase 1 (DNA damage-regulated overexpressed in cancer 45) (DOC45) (GTP-binding protein 9)	OLA1 GTPBP9 PRO2455 PTD004	Homo sapiens (Human)	396	centrosome [GO:0005813]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; GTP binding [GO:0005525]; metal ion binding [GO:0046872]; ribosomal large subunit binding [GO:0043023]; ribosome binding [GO:0043022]; ATP metabolic process [GO:0046034]	ATP metabolic process [GO:0046034]	ATPase activity [GO:0016887]; ATP binding [GO:0005524]; GTP binding [GO:0005525]; metal ion binding [GO:0046872]; ribosomal large subunit binding [GO:0043023]; ribosome binding [GO:0043022]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730]	GO:0005524; GO:0046034; GO:0016887; GO:0005525; GO:0005813; GO:0005737; GO:0070062; GO:0016020; GO:0046872; GO:0005730; GO:0043023; GO:0043022	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03167, ECO:0000269|PubMed:20053727}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03167, ECO:0000269|PubMed:20053727}. Nucleus, nucleolus {ECO:0000255|HAMAP-Rule:MF_03167, ECO:0000269|PubMed:20053727}. Note=Predominantly cytoplasmic, shuttles between the nucleus and the cytoplasm.	3D-structure; ATP-binding; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Magnesium; Metal-binding; Nucleotide-binding; Nucleus; Polymorphism; Reference proteome	Alternative sequence (3); Beta strand (13); Binding site (1); Chain (1); Domain (1); Helix (17); Metal binding (2); Modified residue (1); Motif (1); Mutagenesis (3); Natural variant (1); Nucleotide binding (1); Sequence conflict (4)
PA2G4_HUMAN	Q9UQ80	PA2G4_HUMAN	reviewed	Proliferation-associated protein 2G4 (Cell cycle protein p38-2G4 homolog) (hG4-1) (ErbB3-binding protein 1)	PA2G4 EBP1	Homo sapiens (Human)	394	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]; DNA binding [GO:0003677]; poly(A) RNA binding [GO:0044822]; sequence-specific DNA binding transcription factor activity [GO:0003700]; ubiquitin protein ligase binding [GO:0031625]; cell cycle arrest [GO:0007050]; cell proliferation [GO:0008283]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of cell differentiation [GO:0045597]; regulation of translation [GO:0006417]; rRNA processing [GO:0006364]; transcription, DNA-templated [GO:0006351]	cell cycle arrest [GO:0007050]; cell proliferation [GO:0008283]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of cell differentiation [GO:0045597]; regulation of translation [GO:0006417]; rRNA processing [GO:0006364]; transcription, DNA-templated [GO:0006351]	DNA binding [GO:0003677]; poly(A) RNA binding [GO:0044822]; sequence-specific DNA binding transcription factor activity [GO:0003700]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]	GO:0003677; GO:0007050; GO:0008283; GO:0005737; GO:0070062; GO:0016020; GO:0043066; GO:0045892; GO:0005730; GO:0005654; GO:0005634; GO:0044822; GO:0045597; GO:0006364; GO:0006417; GO:0030529; GO:0003700; GO:0006351; GO:0031625	SUBCELLULAR LOCATION: Isoform 1: Cytoplasm {ECO:0000269|PubMed:16832058, ECO:0000269|PubMed:19037095}. Nucleus, nucleolus {ECO:0000269|PubMed:16832058, ECO:0000269|PubMed:19037095}. Note=Tranlocates to the nucleus upon treatment with HRG. Phosphorylation at Ser-361 by PKC/PRKCD regulates its nucleolar localization. {ECO:0000269|PubMed:16832058}.; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm {ECO:0000269|PubMed:16832058, ECO:0000269|PubMed:19037095}.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Phosphoprotein; RNA-binding; Reference proteome; Repressor; Ribonucleoprotein; Transcription; Transcription regulation; Translation regulation; Ubl conjugation; rRNA processing	Alternative sequence (1); Beta strand (12); Chain (1); Helix (10); Initiator methionine (1); Modified residue (5); Mutagenesis (6); Region (4); Sequence conflict (1); Turn (1)
RS20_HUMAN	P60866	RS20_HUMAN	reviewed	40S ribosomal protein S20	RPS20	Homo sapiens (Human)	119	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; poly(A) RNA binding [GO:0044822]; structural constituent of ribosome [GO:0003735]; cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	poly(A) RNA binding [GO:0044822]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; membrane [GO:0016020]	GO:0006614; GO:0044267; GO:0005737; GO:0005829; GO:0022627; GO:0070062; GO:0010467; GO:0016020; GO:0000184; GO:0044822; GO:0003735; GO:0006412; GO:0006414; GO:0006413; GO:0006415; GO:0019058; GO:0016032; GO:0019083	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Isopeptide bond; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein; Ubl conjugation	Alternative sequence (1); Chain (1); Cross-link (1); Initiator methionine (1); Modified residue (5)
RL10A_HUMAN	P62906	RL10A_HUMAN	reviewed	60S ribosomal protein L10a (CSA-19) (Neural precursor cell expressed developmentally down-regulated protein 6) (NEDD-6)	RPL10A NEDD6	Homo sapiens (Human)	217	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]; poly(A) RNA binding [GO:0044822]; structural constituent of ribosome [GO:0003735]; anatomical structure morphogenesis [GO:0009653]; cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	anatomical structure morphogenesis [GO:0009653]; cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	poly(A) RNA binding [GO:0044822]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0006614; GO:0009653; GO:0044267; GO:0005737; GO:0005829; GO:0022625; GO:0070062; GO:0005925; GO:0010467; GO:0016020; GO:0005739; GO:0000184; GO:0005730; GO:0005634; GO:0044822; GO:0003735; GO:0006412; GO:0006414; GO:0006413; GO:0006415; GO:0019058; GO:0016032; GO:0019083		3D-structure; Acetylation; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome; Ribonucleoprotein; Ribosomal protein	Chain (1); Initiator methionine (1); Modified residue (5); Natural variant (1); Sequence conflict (2)
PUR4_HUMAN	O15067	PUR4_HUMAN	reviewed	Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (FGAR amidotransferase) (FGAR-AT) (Formylglycinamide ribotide amidotransferase)	PFAS KIAA0361	Homo sapiens (Human)	1338	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; phosphoribosylformylglycinamidine synthase activity [GO:0004642]; 'de novo' IMP biosynthetic process [GO:0006189]; glutamine metabolic process [GO:0006541]; nucleobase-containing small molecule metabolic process [GO:0055086]; purine nucleobase metabolic process [GO:0006144]; purine nucleotide biosynthetic process [GO:0006164]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168]; response to drug [GO:0042493]; ribonucleoside monophosphate biosynthetic process [GO:0009156]; small molecule metabolic process [GO:0044281]	'de novo' IMP biosynthetic process [GO:0006189]; glutamine metabolic process [GO:0006541]; nucleobase-containing small molecule metabolic process [GO:0055086]; purine nucleobase metabolic process [GO:0006144]; purine nucleotide biosynthetic process [GO:0006164]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168]; response to drug [GO:0042493]; ribonucleoside monophosphate biosynthetic process [GO:0009156]; small molecule metabolic process [GO:0044281]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; phosphoribosylformylglycinamidine synthase activity [GO:0004642]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0006189; GO:0005524; GO:0005737; GO:0005829; GO:0070062; GO:0006541; GO:0046872; GO:0055086; GO:0004642; GO:0006144; GO:0006164; GO:0009168; GO:0042493; GO:0009156; GO:0044281	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.	ATP-binding; Complete proteome; Cytoplasm; Glutamine amidotransferase; Ligase; Magnesium; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Purine biosynthesis; Reference proteome	Active site (3); Binding site (2); Chain (1); Domain (1); Erroneous initiation (1); Metal binding (4); Modified residue (3); Natural variant (4); Nucleotide binding (2); Sequence conflict (4)
TSR2_HUMAN	Q969E8	TSR2_HUMAN	reviewed	Pre-rRNA-processing protein TSR2 homolog	TSR2	Homo sapiens (Human)	191	nucleus [GO:0005634]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]		nucleus [GO:0005634]	GO:0000462; GO:0005634		Complete proteome; Diamond-Blackfan anemia; Disease mutation; Reference proteome; rRNA processing	Chain (1); Natural variant (1)
TGT_HUMAN	Q9BXR0	TGT_HUMAN	reviewed	Queuine tRNA-ribosyltransferase (EC 2.4.2.29) (Guanine insertion enzyme) (tRNA-guanine transglycosylase)	QTRT1 TGT TGUT	Homo sapiens (Human)	403	mitochondrion [GO:0005739]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; queuine tRNA-ribosyltransferase activity [GO:0008479]; queuosine biosynthetic process [GO:0008616]; tRNA modification [GO:0006400]	queuosine biosynthetic process [GO:0008616]; tRNA modification [GO:0006400]	metal ion binding [GO:0046872]; queuine tRNA-ribosyltransferase activity [GO:0008479]	mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0046872; GO:0005739; GO:0005634; GO:0008479; GO:0008616; GO:0006400	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}. Nucleus {ECO:0000250}. Note=Weakly associates with mitochondria, possibly via QTRTD1. {ECO:0000250}.	Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Glycosyltransferase; Metal-binding; Mitochondrion; Nucleus; Queuosine biosynthesis; Reference proteome; Transferase; Zinc; tRNA processing	Active site (1); Alternative sequence (2); Binding site (1); Chain (1); Erroneous initiation (1); Initiator methionine (1); Metal binding (4); Modified residue (1)
UBR7_HUMAN	Q8N806	UBR7_HUMAN	reviewed	Putative E3 ubiquitin-protein ligase UBR7 (EC 6.3.2.-) (N-recognin-7)	UBR7 C14orf130	Homo sapiens (Human)	425	ligase activity [GO:0016874]; zinc ion binding [GO:0008270]; protein ubiquitination [GO:0016567]	protein ubiquitination [GO:0016567]	ligase activity [GO:0016874]; zinc ion binding [GO:0008270]		GO:0016874; GO:0016567; GO:0008270		Complete proteome; Ligase; Metal-binding; Phosphoprotein; Reference proteome; Ubl conjugation pathway; Zinc; Zinc-finger	Chain (1); Erroneous initiation (3); Modified residue (1); Sequence conflict (4); Zinc finger (2)
SRRT_HUMAN	Q9BXP5	SRRT_HUMAN	reviewed	Serrate RNA effector molecule homolog (Arsenite-resistance protein 2)	SRRT ARS2 ASR2	Homo sapiens (Human)	876	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; poly(A) RNA binding [GO:0044822]; cell proliferation [GO:0008283]; neuronal stem cell maintenance [GO:0097150]; primary miRNA processing [GO:0031053]; regulation of transcription, DNA-templated [GO:0006355]; response to arsenic-containing substance [GO:0046685]; transcription, DNA-templated [GO:0006351]	cell proliferation [GO:0008283]; neuronal stem cell maintenance [GO:0097150]; primary miRNA processing [GO:0031053]; regulation of transcription, DNA-templated [GO:0006355]; response to arsenic-containing substance [GO:0046685]; transcription, DNA-templated [GO:0006351]	DNA binding [GO:0003677]; poly(A) RNA binding [GO:0044822]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003677; GO:0008283; GO:0005737; GO:0097150; GO:0005654; GO:0005634; GO:0044822; GO:0031053; GO:0006355; GO:0046685; GO:0006351	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Predominantly nuclear. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent way (By similarity). {ECO:0000250}.	Acetylation; Activator; Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; RNA-mediated gene silencing; Reference proteome; Transcription; Transcription regulation	Alternative sequence (4); Chain (1); Compositional bias (3); Erroneous gene model prediction (1); Erroneous initiation (2); Frameshift (1); Initiator methionine (1); Modified residue (9); Sequence conflict (8)
S36A4_HUMAN	Q6YBV0	S36A4_HUMAN	reviewed	Proton-coupled amino acid transporter 4 (Proton/amino acid transporter 4) (Solute carrier family 36 member 4)	SLC36A4 PAT4	Homo sapiens (Human)	504	integral component of membrane [GO:0016021]; vacuolar membrane [GO:0005774]; amino acid transmembrane transporter activity [GO:0015171]; symporter activity [GO:0015293]; amino acid transmembrane transport [GO:0003333]; L-alanine transport [GO:0015808]; proline transport [GO:0015824]; tryptophan transport [GO:0015827]	amino acid transmembrane transport [GO:0003333]; L-alanine transport [GO:0015808]; proline transport [GO:0015824]; tryptophan transport [GO:0015827]	amino acid transmembrane transporter activity [GO:0015171]; symporter activity [GO:0015293]	integral component of membrane [GO:0016021]; vacuolar membrane [GO:0005774]	GO:0015808; GO:0003333; GO:0015171; GO:0016021; GO:0015824; GO:0015293; GO:0015827; GO:0005774	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.	Acetylation; Alternative splicing; Amino-acid transport; Complete proteome; Glycoprotein; Membrane; Polymorphism; Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport	Alternative sequence (1); Chain (1); Frameshift (1); Glycosylation (1); Modified residue (1); Natural variant (3); Sequence conflict (3); Transmembrane (10)
UCK2_HUMAN	Q9BZX2	UCK2_HUMAN	reviewed	Uridine-cytidine kinase 2 (UCK 2) (EC 2.7.1.48) (Cytidine monophosphokinase 2) (Testis-specific protein TSA903) (Uridine monophosphokinase 2)	UCK2 UMPK	Homo sapiens (Human)	261	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; ATP binding [GO:0005524]; nucleoside kinase activity [GO:0019206]; uridine kinase activity [GO:0004849]; cellular response to oxygen levels [GO:0071453]; CMP salvage [GO:0006238]; CTP salvage [GO:0044211]; feeding behavior [GO:0007631]; nucleobase-containing small molecule metabolic process [GO:0055086]; pyrimidine nucleobase metabolic process [GO:0006206]; pyrimidine nucleoside salvage [GO:0043097]; response to axon injury [GO:0048678]; small molecule metabolic process [GO:0044281]; UMP salvage [GO:0044206]	cellular response to oxygen levels [GO:0071453]; CMP salvage [GO:0006238]; CTP salvage [GO:0044211]; feeding behavior [GO:0007631]; nucleobase-containing small molecule metabolic process [GO:0055086]; pyrimidine nucleobase metabolic process [GO:0006206]; pyrimidine nucleoside salvage [GO:0043097]; response to axon injury [GO:0048678]; small molecule metabolic process [GO:0044281]; UMP salvage [GO:0044206]	ATP binding [GO:0005524]; nucleoside kinase activity [GO:0019206]; uridine kinase activity [GO:0004849]	cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]	GO:0005524; GO:0006238; GO:0044211; GO:0044206; GO:0071453; GO:0005829; GO:0007631; GO:0043231; GO:0055086; GO:0019206; GO:0006206; GO:0043097; GO:0048678; GO:0044281; GO:0004849		3D-structure; ATP-binding; Acetylation; Alternative splicing; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase	Alternative sequence (1); Beta strand (7); Binding site (7); Chain (1); Helix (14); Initiator methionine (1); Modified residue (2); Nucleotide binding (1); Sequence conflict (2); Turn (2)
RS21_HUMAN	P63220	RS21_HUMAN	reviewed	40S ribosomal protein S21	RPS21	Homo sapiens (Human)	83	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; small ribosomal subunit [GO:0015935]; poly(A) RNA binding [GO:0044822]; protein N-terminus binding [GO:0047485]; structural constituent of ribosome [GO:0003735]; cellular protein metabolic process [GO:0044267]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000461]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; ribosomal small subunit biogenesis [GO:0042274]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	cellular protein metabolic process [GO:0044267]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000461]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; ribosomal small subunit biogenesis [GO:0042274]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	poly(A) RNA binding [GO:0044822]; protein N-terminus binding [GO:0047485]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; small ribosomal subunit [GO:0015935]	GO:0006614; GO:0044267; GO:0005737; GO:0005829; GO:0022627; GO:0000447; GO:0000461; GO:0010467; GO:0000184; GO:0044822; GO:0047485; GO:0042274; GO:0015935; GO:0003735; GO:0006412; GO:0006414; GO:0006413; GO:0006415; GO:0019058; GO:0016032; GO:0019083		3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Reference proteome; Ribonucleoprotein; Ribosomal protein	Chain (1); Modified residue (2)
RS18_HUMAN	P62269	RS18_HUMAN	reviewed	40S ribosomal protein S18 (Ke-3) (Ke3)	RPS18 D6S218E	Homo sapiens (Human)	152	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; ribosome [GO:0005840]; small ribosomal subunit [GO:0015935]; poly(A) RNA binding [GO:0044822]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	poly(A) RNA binding [GO:0044822]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; ribosome [GO:0005840]; small ribosomal subunit [GO:0015935]	GO:0006614; GO:0044267; GO:0005737; GO:0005829; GO:0022627; GO:0070062; GO:0005925; GO:0010467; GO:0016020; GO:0000184; GO:0005634; GO:0044822; GO:0019843; GO:0005840; GO:0015935; GO:0003735; GO:0006412; GO:0006414; GO:0006413; GO:0006415; GO:0019058; GO:0016032; GO:0019083	SUBCELLULAR LOCATION: Cytoplasm.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; RNA-binding; Reference proteome; Ribonucleoprotein; Ribosomal protein; rRNA-binding	Chain (1); Initiator methionine (1); Modified residue (3); Sequence conflict (1)
IF2GL_HUMAN	Q2VIR3	IF2GL_HUMAN	reviewed	Putative eukaryotic translation initiation factor 2 subunit 3-like protein (Eukaryotic translation initiation factor 2 subunit gamma A) (eIF-2-gamma A) (eIF-2gA)	EIF2S3L	Homo sapiens (Human)	472	GTP binding [GO:0005525]; GTPase activity [GO:0003924]; translation initiation factor activity [GO:0003743]		GTPase activity [GO:0003924]; GTP binding [GO:0005525]; translation initiation factor activity [GO:0003743]		GO:0005525; GO:0003924; GO:0003743		Acetylation; Alternative splicing; Complete proteome; GTP-binding; Initiation factor; Nucleotide-binding; Phosphoprotein; Protein biosynthesis; Reference proteome	Alternative sequence (1); Chain (1); Domain (1); Erroneous gene model prediction (1); Frameshift (1); Initiator methionine (1); Modified residue (2); Nucleotide binding (3); Region (5); Sequence conflict (7)
SP100_HUMAN	P23497	SP100_HUMAN	reviewed	Nuclear autoantigen Sp-100 (Nuclear dot-associated Sp100 protein) (Speckled 100 kDa)	SP100	Homo sapiens (Human)	879	cytoplasm [GO:0005737]; nuclear periphery [GO:0034399]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; chromatin binding [GO:0003682]; chromo shadow domain binding [GO:0070087]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; transcription factor binding [GO:0008134]; cellular protein metabolic process [GO:0044267]; chromatin remodeling [GO:0006338]; cytokine-mediated signaling pathway [GO:0019221]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; interferon-gamma-mediated signaling pathway [GO:0060333]; negative regulation of cellular component movement [GO:0051271]; negative regulation of DNA binding [GO:0043392]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of nucleic acid-templated transcription [GO:1903507]; negative regulation of protein export from nucleus [GO:0046826]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of viral transcription [GO:0032897]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription, DNA-templated [GO:0045893]; post-translational protein modification [GO:0043687]; protein sumoylation [GO:0016925]; regulation of angiogenesis [GO:0045765]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]; regulation of Fas signaling pathway [GO:1902044]; response to cytokine [GO:0034097]; response to interferon-gamma [GO:0034341]; response to retinoic acid [GO:0032526]; response to type I interferon [GO:0034340]; retinoic acid receptor signaling pathway [GO:0048384]; telomere maintenance [GO:0000723]; transcription, DNA-templated [GO:0006351]; type I interferon signaling pathway [GO:0060337]; viral process [GO:0016032]	cellular protein metabolic process [GO:0044267]; chromatin remodeling [GO:0006338]; cytokine-mediated signaling pathway [GO:0019221]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; interferon-gamma-mediated signaling pathway [GO:0060333]; negative regulation of cellular component movement [GO:0051271]; negative regulation of DNA binding [GO:0043392]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of nucleic acid-templated transcription [GO:1903507]; negative regulation of protein export from nucleus [GO:0046826]; negative regulation of sequence-specific DNA binding transcription factor activity [GO:0043433]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of viral transcription [GO:0032897]; positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091]; positive regulation of transcription, DNA-templated [GO:0045893]; post-translational protein modification [GO:0043687]; protein sumoylation [GO:0016925]; regulation of angiogenesis [GO:0045765]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]; regulation of Fas signaling pathway [GO:1902044]; response to cytokine [GO:0034097]; response to interferon-gamma [GO:0034341]; response to retinoic acid [GO:0032526]; response to type I interferon [GO:0034340]; retinoic acid receptor signaling pathway [GO:0048384]; telomere maintenance [GO:0000723]; transcription, DNA-templated [GO:0006351]; type I interferon signaling pathway [GO:0060337]; viral process [GO:0016032]	chromatin binding [GO:0003682]; chromo shadow domain binding [GO:0070087]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; transcription factor binding [GO:0008134]	cytoplasm [GO:0005737]; nuclear periphery [GO:0034399]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	GO:0003677; GO:0006978; GO:0016605; GO:0044267; GO:0003682; GO:0006338; GO:0070087; GO:0019221; GO:0005737; GO:0042802; GO:0060333; GO:0019900; GO:0043392; GO:0051271; GO:0010596; GO:1903507; GO:0046826; GO:0043433; GO:0000122; GO:0045892; GO:0032897; GO:0034399; GO:0005730; GO:0005654; GO:0005634; GO:0051091; GO:0045893; GO:0043687; GO:0019904; GO:0042803; GO:0016925; GO:1902044; GO:0045765; GO:1902041; GO:0034097; GO:0034341; GO:0032526; GO:0034340; GO:0048384; GO:0000723; GO:0003713; GO:0003714; GO:0008134; GO:0006351; GO:0060337; GO:0016032	SUBCELLULAR LOCATION: Nucleus. Nucleus, PML body. Cytoplasm. Note=Differences in the subnuclear localization of the different isoforms seem to exist and may also be cell cycle- and interferon-dependent. Accumulates in the cytoplasm upon FAS activation.; SUBCELLULAR LOCATION: Isoform Sp100-C: Nucleus {ECO:0000269|PubMed:11313457}. Note=Forms a reticulate or track-like nuclear pattern with denser concentrations at the nuclear lamina and surrounding the nucleoli, a pattern reminiscent of heterochromatin-rich regions according to PubMed:11313457.	3D-structure; Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; DNA-binding; Host-virus interaction; Isopeptide bond; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Ubl conjugation	Alternative sequence (10); Beta strand (5); Chain (1); Compositional bias (5); Cross-link (1); DNA binding (2); Domain (2); Helix (6); Initiator methionine (1); Modified residue (10); Motif (5); Mutagenesis (2); Natural variant (3); Region (1); Sequence conflict (7); Turn (1)
HSP74_HUMAN	P34932	HSP74_HUMAN	reviewed	Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2)	HSPA4 APG2	Homo sapiens (Human)	840	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; ATP binding [GO:0005524]; chaperone-mediated protein complex assembly [GO:0051131]; protein import into mitochondrial outer membrane [GO:0045040]; response to unfolded protein [GO:0006986]	chaperone-mediated protein complex assembly [GO:0051131]; protein import into mitochondrial outer membrane [GO:0045040]; response to unfolded protein [GO:0006986]	ATP binding [GO:0005524]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0005524; GO:0051131; GO:0005829; GO:0070062; GO:0045040; GO:0006986	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.	ATP-binding; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleotide-binding; Phosphoprotein; Reference proteome; Stress response	Alternative sequence (1); Chain (1); Frameshift (1); Modified residue (9); Sequence conflict (6)
RINI_HUMAN	P13489	RINI_HUMAN	reviewed	Ribonuclease inhibitor (Placental ribonuclease inhibitor) (Placental RNase inhibitor) (Ribonuclease/angiogenin inhibitor 1) (RAI)	RNH1 PRI RNH	Homo sapiens (Human)	461	angiogenin-PRI complex [GO:0032311]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; ribonuclease inhibitor activity [GO:0008428]; mRNA catabolic process [GO:0006402]; negative regulation of catalytic activity [GO:0043086]; regulation of angiogenesis [GO:0045765]	mRNA catabolic process [GO:0006402]; negative regulation of catalytic activity [GO:0043086]; regulation of angiogenesis [GO:0045765]	ribonuclease inhibitor activity [GO:0008428]	angiogenin-PRI complex [GO:0032311]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]	GO:0032311; GO:0005737; GO:0070062; GO:0006402; GO:0043086; GO:0045765; GO:0008428	SUBCELLULAR LOCATION: Cytoplasm.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Leucine-rich repeat; Phosphoprotein; Polymorphism; Reference proteome; Repeat	Beta strand (23); Chain (1); Helix (19); Initiator methionine (1); Modified residue (3); Mutagenesis (7); Natural variant (1); Region (1); Repeat (15); Sequence conflict (5)
EXOS4_HUMAN	Q9NPD3	EXOS4_HUMAN	reviewed	Exosome complex component RRP41 (Exosome component 4) (Ribosomal RNA-processing protein 41) (p12A)	EXOSC4 RRP41 SKI6	Homo sapiens (Human)	245	cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; exosome (RNase complex) [GO:0000178]; nuclear exosome (RNase complex) [GO:0000176]; nucleolus [GO:0005730]; nucleus [GO:0005634]; transcriptionally active chromatin [GO:0035327]; 3'-5'-exoribonuclease activity [GO:0000175]; AU-rich element binding [GO:0017091]; defense response to virus [GO:0051607]; DNA deamination [GO:0045006]; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [GO:0043928]; gene expression [GO:0010467]; histone mRNA catabolic process [GO:0071044]; maturation of 5.8S rRNA [GO:0000460]; nuclear mRNA surveillance [GO:0071028]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; polyadenylation-dependent snoRNA 3'-end processing [GO:0071051]; positive regulation of cell growth [GO:0030307]; RNA phosphodiester bond hydrolysis, exonucleolytic [GO:0090503]; rRNA 3'-end processing [GO:0031125]; rRNA catabolic process [GO:0016075]; rRNA processing [GO:0006364]; U4 snRNA 3'-end processing [GO:0034475]	defense response to virus [GO:0051607]; DNA deamination [GO:0045006]; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [GO:0043928]; gene expression [GO:0010467]; histone mRNA catabolic process [GO:0071044]; maturation of 5.8S rRNA [GO:0000460]; nuclear mRNA surveillance [GO:0071028]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; polyadenylation-dependent snoRNA 3'-end processing [GO:0071051]; positive regulation of cell growth [GO:0030307]; RNA phosphodiester bond hydrolysis, exonucleolytic [GO:0090503]; rRNA 3'-end processing [GO:0031125]; rRNA catabolic process [GO:0016075]; rRNA processing [GO:0006364]; U4 snRNA 3'-end processing [GO:0034475]	3'-5'-exoribonuclease activity [GO:0000175]; AU-rich element binding [GO:0017091]	cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; exosome (RNase complex) [GO:0000178]; nuclear exosome (RNase complex) [GO:0000176]; nucleolus [GO:0005730]; nucleus [GO:0005634]; transcriptionally active chromatin [GO:0035327]	GO:0000175; GO:0017091; GO:0045006; GO:0090503; GO:0034475; GO:0005737; GO:0000177; GO:0005829; GO:0051607; GO:0043928; GO:0000178; GO:0010467; GO:0071044; GO:0000460; GO:0000176; GO:0071028; GO:0000956; GO:0000288; GO:0034427; GO:0005730; GO:0005634; GO:0071051; GO:0030307; GO:0031125; GO:0016075; GO:0006364; GO:0035327	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17545563}. Nucleus, nucleolus {ECO:0000269|PubMed:17545563}. Nucleus {ECO:0000269|PubMed:17545563}.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Exosome; Nucleus; RNA-binding; Reference proteome; rRNA processing	Beta strand (12); Chain (1); Helix (5); Initiator methionine (1); Modified residue (1); Turn (3)
PSMF1_HUMAN	Q92530	PSMF1_HUMAN	reviewed	Proteasome inhibitor PI31 subunit (hPI31)	PSMF1	Homo sapiens (Human)	271	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; proteasome core complex [GO:0005839]; endopeptidase inhibitor activity [GO:0004866]; proteasome binding [GO:0070628]; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of proteasomal protein catabolic process [GO:1901799]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; ubiquitin-dependent protein catabolic process [GO:0006511]; viral process [GO:0016032]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of proteasomal protein catabolic process [GO:1901799]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; ubiquitin-dependent protein catabolic process [GO:0006511]; viral process [GO:0016032]	endopeptidase inhibitor activity [GO:0004866]; proteasome binding [GO:0070628]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; proteasome core complex [GO:0005839]	GO:0006977; GO:0000082; GO:0031145; GO:0042590; GO:0002479; GO:0002474; GO:0006915; GO:0034641; GO:0005737; GO:0005829; GO:0004866; GO:0005783; GO:0010467; GO:0045087; GO:0016020; GO:0000278; GO:0043066; GO:0090090; GO:0010951; GO:1901799; GO:0051436; GO:0005654; GO:0090263; GO:0051437; GO:0012501; GO:0070628; GO:0005839; GO:0000209; GO:0042981; GO:0006521; GO:0051439; GO:0044281; GO:0002223; GO:0006511; GO:0016032	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18495667}. Endoplasmic reticulum {ECO:0000269|PubMed:18495667}.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Endoplasmic reticulum; Phosphoprotein; Polymorphism; Proteasome; Reference proteome	Beta strand (7); Chain (1); Compositional bias (1); Helix (7); Initiator methionine (1); Modified residue (2); Mutagenesis (3); Natural variant (2); Region (1); Turn (4)
Q5QPM7_HUMAN	Q5QPM7	Q5QPM7_HUMAN	unreviewed	Proteasome inhibitor PI31 subunit	PSMF1	Homo sapiens (Human)	263	cytoplasm [GO:0005737]			cytoplasm [GO:0005737]	GO:0005737		Complete proteome; Proteomics identification; Reference proteome	
DCTN3_HUMAN	O75935	DCTN3_HUMAN	reviewed	Dynactin subunit 3 (Dynactin complex subunit 22 kDa subunit) (p22)	DCTN3 DCTN22	Homo sapiens (Human)	186	centrosome [GO:0005813]; cleavage furrow [GO:0032154]; condensed chromosome kinetochore [GO:0000777]; cytosol [GO:0005829]; dynactin complex [GO:0005869]; midbody [GO:0030496]; perinuclear region of cytoplasm [GO:0048471]; spindle [GO:0005819]; structural molecule activity [GO:0005198]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; cytokinesis [GO:0000910]; G2/M transition of mitotic cell cycle [GO:0000086]; microtubule-based process [GO:0007017]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; organelle organization [GO:0006996]	antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; cytokinesis [GO:0000910]; G2/M transition of mitotic cell cycle [GO:0000086]; microtubule-based process [GO:0007017]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; organelle organization [GO:0006996]	structural molecule activity [GO:0005198]	centrosome [GO:0005813]; cleavage furrow [GO:0032154]; condensed chromosome kinetochore [GO:0000777]; cytosol [GO:0005829]; dynactin complex [GO:0005869]; midbody [GO:0030496]; perinuclear region of cytoplasm [GO:0048471]; spindle [GO:0005819]	GO:0000086; GO:0019886; GO:0005813; GO:0032154; GO:0000777; GO:0000910; GO:0005829; GO:0005869; GO:0007017; GO:0030496; GO:0000278; GO:0007067; GO:0006996; GO:0048471; GO:0005819; GO:0005198	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9722614}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:9722614}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:9722614}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:9722614}. Cleavage furrow {ECO:0000269|PubMed:9722614}. Midbody {ECO:0000269|PubMed:9722614}. Note=Localizes to punctate cytoplasmic structures and to the centrosome during interphase, and to kinetochores and to spindle poles throughout mitosis. Colocalizes with dynein to the cleavage furrow and to midbody of dividing cells.	Acetylation; Alternative splicing; Cell cycle; Cell division; Centromere; Chromosome; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Kinetochore; Mitosis; Reference proteome	Alternative sequence (2); Chain (1); Coiled coil (1); Erroneous gene model prediction (1); Erroneous initiation (2); Initiator methionine (1); Modified residue (1)
I3L297_HUMAN	I3L297	I3L297_HUMAN	unreviewed	Adapter molecule crk	CRK	Homo sapiens (Human)	223							Complete proteome; Proteomics identification; Reference proteome	
BRK1_HUMAN	Q8WUW1	BRK1_HUMAN	reviewed	Protein BRICK1 (BRK1)	BRK1 C3orf10 HSPC300 MDS027	Homo sapiens (Human)	75	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lamellipodium [GO:0030027]; SCAR complex [GO:0031209]; protein complex binding [GO:0032403]; actin cytoskeleton organization [GO:0030036]; cell motility [GO:0048870]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; in utero embryonic development [GO:0001701]; innate immune response [GO:0045087]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; positive regulation of cell proliferation [GO:0008284]; positive regulation of lamellipodium assembly [GO:0010592]; protein homotrimerization [GO:0070207]; Rac protein signal transduction [GO:0016601]; small GTPase mediated signal transduction [GO:0007264]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	actin cytoskeleton organization [GO:0030036]; cell motility [GO:0048870]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; innate immune response [GO:0045087]; in utero embryonic development [GO:0001701]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; positive regulation of cell proliferation [GO:0008284]; positive regulation of lamellipodium assembly [GO:0010592]; protein homotrimerization [GO:0070207]; Rac protein signal transduction [GO:0016601]; small GTPase mediated signal transduction [GO:0007264]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	protein complex binding [GO:0032403]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lamellipodium [GO:0030027]; SCAR complex [GO:0031209]	GO:0038096; GO:0016601; GO:0031209; GO:0030036; GO:0048870; GO:0005856; GO:0005829; GO:0070062; GO:0001701; GO:0045087; GO:0030027; GO:2000601; GO:0008284; GO:0010592; GO:0032403; GO:0070207; GO:0007264; GO:0048010	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.	3D-structure; Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Reference proteome	Alternative sequence (1); Chain (1); Coiled coil (1); Erroneous initiation (1); Helix (1); Initiator methionine (1); Modified residue (1)
E7EUY0_HUMAN	E7EUY0	E7EUY0_HUMAN		Deleted.											
PRKDC_HUMAN	P78527	PRKDC_HUMAN	reviewed	DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (p460)	PRKDC HYRC HYRC1	Homo sapiens (Human)	4128	cytosol [GO:0005829]; DNA-dependent protein kinase-DNA ligase 4 complex [GO:0005958]; membrane [GO:0016020]; nonhomologous end joining complex [GO:0070419]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; transcription factor complex [GO:0005667]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA-dependent protein kinase activity [GO:0004677]; poly(A) RNA binding [GO:0044822]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; transcription factor binding [GO:0008134]; B cell lineage commitment [GO:0002326]; brain development [GO:0007420]; cellular protein modification process [GO:0006464]; cellular response to insulin stimulus [GO:0032869]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; ectopic germ cell programmed cell death [GO:0035234]; heart development [GO:0007507]; immunoglobulin V(D)J recombination [GO:0033152]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein phosphorylation [GO:0001933]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of apoptotic process [GO:0043065]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of type I interferon production [GO:0032481]; pro-B cell differentiation [GO:0002328]; protein destabilization [GO:0031648]; regulation of circadian rhythm [GO:0042752]; response to gamma radiation [GO:0010332]; rhythmic process [GO:0048511]; signal transduction involved in mitotic G1 DNA damage checkpoint [GO:0072431]; somitogenesis [GO:0001756]; T cell differentiation in thymus [GO:0033077]; T cell lineage commitment [GO:0002360]; T cell receptor V(D)J recombination [GO:0033153]; telomere maintenance [GO:0000723]	B cell lineage commitment [GO:0002326]; brain development [GO:0007420]; cellular protein modification process [GO:0006464]; cellular response to insulin stimulus [GO:0032869]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; ectopic germ cell programmed cell death [GO:0035234]; heart development [GO:0007507]; immunoglobulin V(D)J recombination [GO:0033152]; innate immune response [GO:0045087]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein phosphorylation [GO:0001933]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of apoptotic process [GO:0043065]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of type I interferon production [GO:0032481]; pro-B cell differentiation [GO:0002328]; protein destabilization [GO:0031648]; regulation of circadian rhythm [GO:0042752]; response to gamma radiation [GO:0010332]; rhythmic process [GO:0048511]; signal transduction involved in mitotic G1 DNA damage checkpoint [GO:0072431]; somitogenesis [GO:0001756]; T cell differentiation in thymus [GO:0033077]; T cell lineage commitment [GO:0002360]; T cell receptor V(D)J recombination [GO:0033153]; telomere maintenance [GO:0000723]	ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA-dependent protein kinase activity [GO:0004677]; poly(A) RNA binding [GO:0044822]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; transcription factor binding [GO:0008134]	cytosol [GO:0005829]; DNA-dependent protein kinase-DNA ligase 4 complex [GO:0005958]; membrane [GO:0016020]; nonhomologous end joining complex [GO:0070419]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; transcription factor complex [GO:0005667]	GO:0005524; GO:0002326; GO:0003677; GO:0006281; GO:0004677; GO:0005958; GO:0033077; GO:0002360; GO:0033153; GO:0007420; GO:0006464; GO:0032869; GO:0005829; GO:0006302; GO:0000724; GO:0006303; GO:0035234; GO:0007507; GO:0033152; GO:0045087; GO:0008630; GO:0016020; GO:0043066; GO:0001933; GO:0070419; GO:0005730; GO:0005654; GO:0018105; GO:0044822; GO:0043065; GO:0045944; GO:0032481; GO:0002328; GO:0031648; GO:0004672; GO:0004674; GO:0042752; GO:0010332; GO:0048511; GO:0072431; GO:0001756; GO:0000723; GO:0008134; GO:0005667	SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus.	ATP-binding; Acetylation; Alternative splicing; Biological rhythms; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA-binding; Disease mutation; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; SCID; Serine/threonine-protein kinase; TPR repeat; Transferase; Ubl conjugation	Alternative sequence (1); Chain (1); Domain (3); Modified residue (18); Mutagenesis (6); Natural variant (44); Region (3); Repeat (5); Sequence conflict (6); Site (1)
SPF27_HUMAN	O75934	SPF27_HUMAN	reviewed	Pre-mRNA-splicing factor SPF27 (Breast carcinoma-amplified sequence 2) (DNA amplified in mammary carcinoma 1 protein) (Spliceosome-associated protein SPF 27)	BCAS2 DAM1	Homo sapiens (Human)	225	cell junction [GO:0030054]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; gene expression [GO:0010467]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]	gene expression [GO:0010467]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]		cell junction [GO:0030054]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]	GO:0008380; GO:0000375; GO:0030054; GO:0010467; GO:0000398; GO:0005730; GO:0005654; GO:0005634; GO:0005681	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12169396, ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:20176811}.	Acetylation; Coiled coil; Complete proteome; Direct protein sequencing; Nucleus; Polymorphism; Reference proteome; Spliceosome; mRNA processing; mRNA splicing	Chain (1); Coiled coil (1); Initiator methionine (1); Modified residue (1); Natural variant (1); Sequence conflict (2)
SERA_HUMAN	O43175	SERA_HUMAN	reviewed	D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95)	PHGDH PGDH3	Homo sapiens (Human)	533	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; electron carrier activity [GO:0009055]; NAD binding [GO:0051287]; phosphoglycerate dehydrogenase activity [GO:0004617]; brain development [GO:0007420]; cellular amino acid biosynthetic process [GO:0008652]; cellular nitrogen compound metabolic process [GO:0034641]; G1 to G0 transition [GO:0070314]; gamma-aminobutyric acid metabolic process [GO:0009448]; glial cell development [GO:0021782]; glutamine metabolic process [GO:0006541]; glycine metabolic process [GO:0006544]; L-serine biosynthetic process [GO:0006564]; neural tube development [GO:0021915]; neuron projection development [GO:0031175]; regulation of gene expression [GO:0010468]; small molecule metabolic process [GO:0044281]; spinal cord development [GO:0021510]; taurine metabolic process [GO:0019530]; threonine metabolic process [GO:0006566]	brain development [GO:0007420]; cellular amino acid biosynthetic process [GO:0008652]; cellular nitrogen compound metabolic process [GO:0034641]; G1 to G0 transition [GO:0070314]; gamma-aminobutyric acid metabolic process [GO:0009448]; glial cell development [GO:0021782]; glutamine metabolic process [GO:0006541]; glycine metabolic process [GO:0006544]; L-serine biosynthetic process [GO:0006564]; neural tube development [GO:0021915]; neuron projection development [GO:0031175]; regulation of gene expression [GO:0010468]; small molecule metabolic process [GO:0044281]; spinal cord development [GO:0021510]; taurine metabolic process [GO:0019530]; threonine metabolic process [GO:0006566]	electron carrier activity [GO:0009055]; NAD binding [GO:0051287]; phosphoglycerate dehydrogenase activity [GO:0004617]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0070314; GO:0006564; GO:0051287; GO:0007420; GO:0008652; GO:0034641; GO:0005829; GO:0009055; GO:0070062; GO:0009448; GO:0021782; GO:0006541; GO:0006544; GO:0021915; GO:0031175; GO:0004617; GO:0010468; GO:0044281; GO:0021510; GO:0019530; GO:0006566		3D-structure; Acetylation; Amino-acid biosynthesis; Complete proteome; Direct protein sequencing; Disease mutation; NAD; Oxidoreductase; Phosphoprotein; Reference proteome; Serine biosynthesis	Active site (3); Beta strand (14); Binding site (4); Chain (1); Helix (16); Initiator methionine (1); Modified residue (5); Natural variant (8); Nucleotide binding (3); Sequence conflict (2); Turn (2)
B4DUX5_HUMAN	B4DUX5	B4DUX5_HUMAN		Merged into P50579.											
DREB_HUMAN	Q16643	DREB_HUMAN	reviewed	Drebrin (Developmentally-regulated brain protein)	DBN1 D0S117E	Homo sapiens (Human)	649	actin cytoskeleton [GO:0015629]; actomyosin [GO:0042641]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; gap junction [GO:0005921]; plasma membrane [GO:0005886]; actin binding [GO:0003779]; profilin binding [GO:0005522]; actin filament organization [GO:0007015]; cell communication by chemical coupling [GO:0010643]; cell communication by electrical coupling [GO:0010644]; maintenance of protein location in cell [GO:0032507]; neural precursor cell proliferation [GO:0061351]; regulation of dendrite development [GO:0050773]; regulation of neuronal synaptic plasticity [GO:0048168]	actin filament organization [GO:0007015]; cell communication by chemical coupling [GO:0010643]; cell communication by electrical coupling [GO:0010644]; maintenance of protein location in cell [GO:0032507]; neural precursor cell proliferation [GO:0061351]; regulation of dendrite development [GO:0050773]; regulation of neuronal synaptic plasticity [GO:0048168]	actin binding [GO:0003779]; profilin binding [GO:0005522]	actin cytoskeleton [GO:0015629]; actomyosin [GO:0042641]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; gap junction [GO:0005921]; plasma membrane [GO:0005886]	GO:0003779; GO:0015629; GO:0007015; GO:0042641; GO:0010643; GO:0010644; GO:0005938; GO:0005737; GO:0030425; GO:0005921; GO:0032507; GO:0061351; GO:0005886; GO:0005522; GO:0050773; GO:0048168	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20215400}. Cytoplasm, cell cortex {ECO:0000269|PubMed:20215400}. Cell junction {ECO:0000269|PubMed:20215400}. Note=In the absence of antigen, evenly distributed throughout subcortical regions of the T-cell membrane and cytoplasm. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation clusters (SMAC).	Acetylation; Actin-binding; Alternative splicing; Cell junction; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Direct protein sequencing; Neurogenesis; Phosphoprotein; Polymorphism; Reference proteome	Alternative sequence (2); Chain (1); Domain (1); Initiator methionine (1); Modified residue (10); Natural variant (4)
ANXA5_HUMAN	P08758	ANXA5_HUMAN	reviewed	Annexin A5 (Anchorin CII) (Annexin V) (Annexin-5) (Calphobindin I) (CBP-I) (Endonexin II) (Lipocortin V) (Placental anticoagulant protein 4) (PP4) (Placental anticoagulant protein I) (PAP-I) (Thromboplastin inhibitor) (Vascular anticoagulant-alpha) (VAC-alpha)	ANXA5 ANX5 ENX2 PP4	Homo sapiens (Human)	320	cytoplasm [GO:0005737]; endothelial microparticle [GO:0072563]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; intracellular [GO:0005622]; membrane [GO:0016020]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; phospholipase inhibitor activity [GO:0004859]; phospholipid binding [GO:0005543]; activation of mitophagy in response to mitochondrial depolarization [GO:0098779]; blood coagulation [GO:0007596]; negative regulation of apoptotic process [GO:0043066]; negative regulation of catalytic activity [GO:0043086]; negative regulation of coagulation [GO:0050819]; positive regulation of defense response to virus by host [GO:0002230]; response to organic substance [GO:0010033]; signal transduction [GO:0007165]	activation of mitophagy in response to mitochondrial depolarization [GO:0098779]; blood coagulation [GO:0007596]; negative regulation of apoptotic process [GO:0043066]; negative regulation of catalytic activity [GO:0043086]; negative regulation of coagulation [GO:0050819]; positive regulation of defense response to virus by host [GO:0002230]; response to organic substance [GO:0010033]; signal transduction [GO:0007165]	calcium-dependent phospholipid binding [GO:0005544]; calcium ion binding [GO:0005509]; phospholipase inhibitor activity [GO:0004859]; phospholipid binding [GO:0005543]	cytoplasm [GO:0005737]; endothelial microparticle [GO:0072563]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; intracellular [GO:0005622]; membrane [GO:0016020]	GO:0098779; GO:0007596; GO:0005509; GO:0005544; GO:0005737; GO:0072563; GO:0009897; GO:0070062; GO:0005925; GO:0005622; GO:0016020; GO:0043066; GO:0043086; GO:0050819; GO:0004859; GO:0005543; GO:0002230; GO:0010033; GO:0007165		3D-structure; Acetylation; Annexin; Blood coagulation; Calcium; Calcium/phospholipid-binding; Complete proteome; Direct protein sequencing; Hemostasis; Reference proteome; Repeat; S-nitrosylation	Beta strand (5); Chain (1); Helix (21); Initiator methionine (1); Modified residue (7); Motif (1); Repeat (4); Sequence conflict (2); Turn (2)
LKHA4_HUMAN	P09960	LKHA4_HUMAN	reviewed	Leukotriene A-4 hydrolase (LTA-4 hydrolase) (EC 3.3.2.6) (Leukotriene A(4) hydrolase)	LTA4H LTA4	Homo sapiens (Human)	611	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; aminopeptidase activity [GO:0004177]; epoxide hydrolase activity [GO:0004301]; leukotriene-A4 hydrolase activity [GO:0004463]; metallopeptidase activity [GO:0008237]; peptidase activity [GO:0008233]; poly(A) RNA binding [GO:0044822]; zinc ion binding [GO:0008270]; arachidonic acid metabolic process [GO:0019369]; inflammatory response [GO:0006954]; leukotriene biosynthetic process [GO:0019370]; leukotriene metabolic process [GO:0006691]; peptide catabolic process [GO:0043171]; small molecule metabolic process [GO:0044281]	arachidonic acid metabolic process [GO:0019369]; inflammatory response [GO:0006954]; leukotriene biosynthetic process [GO:0019370]; leukotriene metabolic process [GO:0006691]; peptide catabolic process [GO:0043171]; small molecule metabolic process [GO:0044281]	aminopeptidase activity [GO:0004177]; epoxide hydrolase activity [GO:0004301]; leukotriene-A4 hydrolase activity [GO:0004463]; metallopeptidase activity [GO:0008237]; peptidase activity [GO:0008233]; poly(A) RNA binding [GO:0044822]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]	GO:0004177; GO:0019369; GO:0005737; GO:0005829; GO:0004301; GO:0070062; GO:0006954; GO:0019370; GO:0006691; GO:0004463; GO:0008237; GO:0005654; GO:0008233; GO:0043171; GO:0044822; GO:0044281; GO:0008270	SUBCELLULAR LOCATION: Cytoplasm.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Leukotriene biosynthesis; Metal-binding; Metalloprotease; Phosphoprotein; Polymorphism; Protease; Reference proteome; Zinc	Active site (2); Alternative sequence (3); Beta strand (24); Chain (1); Helix (32); Initiator methionine (1); Metal binding (3); Modified residue (5); Mutagenesis (27); Natural variant (1); Region (3); Sequence conflict (5); Site (2); Turn (8)
RL24_HUMAN	P83731	RL24_HUMAN	reviewed	60S ribosomal protein L24 (60S ribosomal protein L30)	RPL24	Homo sapiens (Human)	157	cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cellular protein metabolic process [GO:0044267]; exit from mitosis [GO:0010458]; gene expression [GO:0010467]; mitotic cell cycle checkpoint [GO:0007093]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; optic nerve development [GO:0021554]; retina development in camera-type eye [GO:0060041]; retinal ganglion cell axon guidance [GO:0031290]; ribosomal large subunit assembly [GO:0000027]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	cellular protein metabolic process [GO:0044267]; exit from mitosis [GO:0010458]; gene expression [GO:0010467]; mitotic cell cycle checkpoint [GO:0007093]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; optic nerve development [GO:0021554]; retina development in camera-type eye [GO:0060041]; retinal ganglion cell axon guidance [GO:0031290]; ribosomal large subunit assembly [GO:0000027]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; membrane [GO:0016020]	GO:0003723; GO:0006614; GO:0044267; GO:0005829; GO:0022625; GO:0010458; GO:0070062; GO:0010467; GO:0016020; GO:0007093; GO:0000184; GO:0021554; GO:0044822; GO:0060041; GO:0031290; GO:0000027; GO:0003735; GO:0006412; GO:0006414; GO:0006413; GO:0006415; GO:0019058; GO:0016032; GO:0019083		3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein	Chain (1); Modified residue (6)
PCBP1_HUMAN	Q15365	PCBP1_HUMAN	reviewed	Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3)	PCBP1	Homo sapiens (Human)	356	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:0030529]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; gene expression [GO:0010467]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]	gene expression [GO:0010467]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]	poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:0030529]	GO:0003723; GO:0008380; GO:0005737; GO:0070062; GO:0010467; GO:0043231; GO:0000398; GO:0016020; GO:0005654; GO:0044822; GO:0030529; GO:0003697	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm.	3D-structure; Acetylation; Complete proteome; Cytoplasm; DNA-binding; Direct protein sequencing; Nucleus; Phosphoprotein; RNA-binding; Reference proteome; Repeat; Ribonucleoprotein	Beta strand (6); Chain (1); Domain (3); Frameshift (1); Helix (9); Modified residue (4); Sequence conflict (2); Turn (1)
RSSA_HUMAN	P08865	RSSA_HUMAN	reviewed	40S ribosomal protein SA (37 kDa laminin receptor precursor) (37LRP) (37/67 kDa laminin receptor) (LRP/LR) (67 kDa laminin receptor) (67LR) (Colon carcinoma laminin-binding protein) (Laminin receptor 1) (LamR) (Laminin-binding protein precursor p40) (LBP/p40) (Multidrug resistance-associated protein MGr1-Ag) (NEM/1CHD4)	RPSA LAMBR LAMR1	Homo sapiens (Human)	295	90S preribosome [GO:0030686]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; laminin receptor activity [GO:0005055]; poly(A) RNA binding [GO:0044822]; ribosome binding [GO:0043022]; structural constituent of ribosome [GO:0003735]; cell adhesion [GO:0007155]; cellular protein metabolic process [GO:0044267]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000461]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; ribosomal small subunit assembly [GO:0000028]; rRNA export from nucleus [GO:0006407]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	cell adhesion [GO:0007155]; cellular protein metabolic process [GO:0044267]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000461]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; ribosomal small subunit assembly [GO:0000028]; rRNA export from nucleus [GO:0006407]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	laminin receptor activity [GO:0005055]; poly(A) RNA binding [GO:0044822]; ribosome binding [GO:0043022]; structural constituent of ribosome [GO:0003735]	90S preribosome [GO:0030686]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0030686; GO:0006614; GO:0007155; GO:0044267; GO:0005737; GO:0005829; GO:0022627; GO:0000447; GO:0000461; GO:0070062; GO:0010467; GO:0005055; GO:0016020; GO:0000184; GO:0005634; GO:0005886; GO:0044822; GO:0006407; GO:0000028; GO:0043022; GO:0003735; GO:0006412; GO:0006414; GO:0006413; GO:0006415; GO:0019058; GO:0016032; GO:0019083	SUBCELLULAR LOCATION: Cell membrane. Cytoplasm. Nucleus {ECO:0000255|HAMAP-Rule:MF_03016}. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus (By similarity). Colocalizes with PPP1R16B in the cell membrane. {ECO:0000255|HAMAP-Rule:MF_03016}.	3D-structure; Acetylation; Cell membrane; Complete proteome; Cytoplasm; Direct protein sequencing; Membrane; Nucleus; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Ribonucleoprotein; Ribosomal protein	Beta strand (8); Chain (1); Helix (8); Initiator methionine (1); Modified residue (4); Natural variant (1); Region (4); Repeat (5); Sequence conflict (7); Site (2); Turn (3)
EIF3C_HUMAN	Q99613	EIF3C_HUMAN	reviewed	Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110)	EIF3C EIF3S8	Homo sapiens (Human)	913	cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; poly(A) RNA binding [GO:0044822]; translation initiation factor activity [GO:0003743]; cellular protein metabolic process [GO:0044267]; formation of translation preinitiation complex [GO:0001731]; gene expression [GO:0010467]; regulation of translational initiation [GO:0006446]; translation [GO:0006412]; translational initiation [GO:0006413]	cellular protein metabolic process [GO:0044267]; formation of translation preinitiation complex [GO:0001731]; gene expression [GO:0010467]; regulation of translational initiation [GO:0006446]; translation [GO:0006412]; translational initiation [GO:0006413]	poly(A) RNA binding [GO:0044822]; translation initiation factor activity [GO:0003743]	cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]	GO:0044267; GO:0005829; GO:0016282; GO:0033290; GO:0005852; GO:0001731; GO:0010467; GO:0044822; GO:0006446; GO:0006412; GO:0003743; GO:0006413	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03002}.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Initiation factor; Phosphoprotein; Protein biosynthesis; Reference proteome	Alternative sequence (1); Chain (1); Compositional bias (3); Domain (1); Mass spectrometry (2); Modified residue (12); Sequence conflict (2)
GRP78_HUMAN	P11021	GRP78_HUMAN	reviewed	78 kDa glucose-regulated protein (GRP-78) (Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78) (Heat shock 70 kDa protein 5) (Immunoglobulin heavy chain-binding protein) (BiP)	HSPA5 GRP78	Homo sapiens (Human)	654	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; integral component of endoplasmic reticulum membrane [GO:0030176]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum [GO:0005790]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; calcium ion binding [GO:0005509]; chaperone binding [GO:0051087]; enzyme binding [GO:0019899]; glycoprotein binding [GO:0001948]; misfolded protein binding [GO:0051787]; protein domain specific binding [GO:0019904]; ribosome binding [GO:0043022]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]; activation of signaling protein activity involved in unfolded protein response [GO:0006987]; ATF6-mediated unfolded protein response [GO:0036500]; blood coagulation [GO:0007596]; cellular protein metabolic process [GO:0044267]; cellular response to antibiotic [GO:0071236]; cellular response to glucose starvation [GO:0042149]; cellular response to interleukin-4 [GO:0071353]; cerebellar Purkinje cell layer development [GO:0021680]; cerebellum structural organization [GO:0021589]; endoplasmic reticulum unfolded protein response [GO:0030968]; ER overload response [GO:0006983]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; IRE1-mediated unfolded protein response [GO:0036498]; maintenance of protein localization in endoplasmic reticulum [GO:0035437]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein homodimerization activity [GO:0090074]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; PERK-mediated unfolded protein response [GO:0036499]; platelet activation [GO:0030168]; platelet degranulation [GO:0002576]; positive regulation of cell migration [GO:0030335]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440]; protein folding in endoplasmic reticulum [GO:0034975]; regulation of ATF6-mediated unfolded protein response [GO:1903891]; regulation of IRE1-mediated unfolded protein response [GO:1903894]; regulation of PERK-mediated unfolded protein response [GO:1903897]; regulation of protein folding in endoplasmic reticulum [GO:0060904]; substantia nigra development [GO:0021762]; toxin transport [GO:1901998]	activation of signaling protein activity involved in unfolded protein response [GO:0006987]; ATF6-mediated unfolded protein response [GO:0036500]; blood coagulation [GO:0007596]; cellular protein metabolic process [GO:0044267]; cellular response to antibiotic [GO:0071236]; cellular response to glucose starvation [GO:0042149]; cellular response to interleukin-4 [GO:0071353]; cerebellar Purkinje cell layer development [GO:0021680]; cerebellum structural organization [GO:0021589]; endoplasmic reticulum unfolded protein response [GO:0030968]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; ER overload response [GO:0006983]; IRE1-mediated unfolded protein response [GO:0036498]; maintenance of protein localization in endoplasmic reticulum [GO:0035437]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein homodimerization activity [GO:0090074]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; PERK-mediated unfolded protein response [GO:0036499]; platelet activation [GO:0030168]; platelet degranulation [GO:0002576]; positive regulation of cell migration [GO:0030335]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440]; protein folding in endoplasmic reticulum [GO:0034975]; regulation of ATF6-mediated unfolded protein response [GO:1903891]; regulation of IRE1-mediated unfolded protein response [GO:1903894]; regulation of PERK-mediated unfolded protein response [GO:1903897]; regulation of protein folding in endoplasmic reticulum [GO:0060904]; substantia nigra development [GO:0021762]; toxin transport [GO:1901998]	ATPase activity [GO:0016887]; ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; chaperone binding [GO:0051087]; enzyme binding [GO:0019899]; glycoprotein binding [GO:0001948]; misfolded protein binding [GO:0051787]; protein domain specific binding [GO:0019904]; ribosome binding [GO:0043022]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]	cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; integral component of endoplasmic reticulum membrane [GO:0030176]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum [GO:0005790]	GO:0036500; GO:0005524; GO:0016887; GO:0006983; GO:0030433; GO:0036498; GO:0036499; GO:0006987; GO:0007596; GO:0005509; GO:0009986; GO:0044267; GO:0071236; GO:0042149; GO:0071353; GO:0021680; GO:0021589; GO:0051087; GO:0005783; GO:0034663; GO:0005788; GO:0005789; GO:0030968; GO:0005793; GO:0019899; GO:0070062; GO:0005925; GO:0001948; GO:0030176; GO:0035437; GO:0042470; GO:0016020; GO:0030496; GO:0051787; GO:0005739; GO:0043066; GO:0090074; GO:0030512; GO:0005634; GO:0005886; GO:0030168; GO:0002576; GO:0030335; GO:0031398; GO:1990440; GO:0019904; GO:0034975; GO:1903891; GO:1903894; GO:1903897; GO:0060904; GO:0043022; GO:0005790; GO:0021762; GO:1901998; GO:0031625; GO:0051082	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen. Melanosome. Cytoplasm {ECO:0000250}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.	3D-structure; ATP-binding; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Endoplasmic reticulum; Methylation; Nitration; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Signal	Beta strand (18); Binding site (1); Chain (1); Helix (18); Modified residue (8); Motif (1); Mutagenesis (1); Natural variant (1); Nucleotide binding (4); Sequence conflict (8); Signal peptide (1); Turn (4)
EIF3D_HUMAN	O15371	EIF3D_HUMAN	reviewed	Eukaryotic translation initiation factor 3 subunit D (eIF3d) (Eukaryotic translation initiation factor 3 subunit 7) (eIF-3-zeta) (eIF3 p66)	EIF3D EIF3S7	Homo sapiens (Human)	548	cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; membrane [GO:0016020]; poly(A) RNA binding [GO:0044822]; translation initiation factor activity [GO:0003743]; cellular protein metabolic process [GO:0044267]; formation of cytoplasmic translation initiation complex [GO:0001732]; formation of translation preinitiation complex [GO:0001731]; gene expression [GO:0010467]; regulation of translational initiation [GO:0006446]; translation [GO:0006412]; translational initiation [GO:0006413]	cellular protein metabolic process [GO:0044267]; formation of cytoplasmic translation initiation complex [GO:0001732]; formation of translation preinitiation complex [GO:0001731]; gene expression [GO:0010467]; regulation of translational initiation [GO:0006446]; translation [GO:0006412]; translational initiation [GO:0006413]	poly(A) RNA binding [GO:0044822]; translation initiation factor activity [GO:0003743]	cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; membrane [GO:0016020]	GO:0044267; GO:0005829; GO:0016282; GO:0033290; GO:0005852; GO:0071541; GO:0001732; GO:0001731; GO:0010467; GO:0016020; GO:0044822; GO:0006446; GO:0006412; GO:0003743; GO:0006413	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03003}.	Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Initiation factor; Phosphoprotein; Protein biosynthesis; Reference proteome	Alternative sequence (2); Chain (1); Compositional bias (1); Mass spectrometry (2); Modified residue (4)
SERC_HUMAN	Q9Y617	SERC_HUMAN	reviewed	Phosphoserine aminotransferase (EC 2.6.1.52) (Phosphohydroxythreonine aminotransferase) (PSAT)	PSAT1 PSA	Homo sapiens (Human)	370	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; O-phospho-L-serine:2-oxoglutarate aminotransferase activity [GO:0004648]; pyridoxal phosphate binding [GO:0030170]; cellular amino acid biosynthetic process [GO:0008652]; cellular nitrogen compound metabolic process [GO:0034641]; L-serine biosynthetic process [GO:0006564]; pyridoxine biosynthetic process [GO:0008615]; small molecule metabolic process [GO:0044281]	cellular amino acid biosynthetic process [GO:0008652]; cellular nitrogen compound metabolic process [GO:0034641]; L-serine biosynthetic process [GO:0006564]; pyridoxine biosynthetic process [GO:0008615]; small molecule metabolic process [GO:0044281]	O-phospho-L-serine:2-oxoglutarate aminotransferase activity [GO:0004648]; pyridoxal phosphate binding [GO:0030170]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0006564; GO:0004648; GO:0008652; GO:0034641; GO:0005737; GO:0005829; GO:0070062; GO:0030170; GO:0008615; GO:0044281		3D-structure; Acetylation; Alternative splicing; Amino-acid biosynthesis; Aminotransferase; Complete proteome; Disease mutation; Polymorphism; Pyridoxal phosphate; Reference proteome; Serine biosynthesis; Transferase	Alternative sequence (1); Beta strand (14); Binding site (5); Chain (1); Helix (15); Modified residue (8); Natural variant (4); Region (2); Sequence conflict (1); Turn (7)
SF3B1_HUMAN	O75533	SF3B1_HUMAN	reviewed	Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155)	SF3B1 SAP155	Homo sapiens (Human)	1304	catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]; chromatin binding [GO:0003682]; poly(A) RNA binding [GO:0044822]; anterior/posterior pattern specification [GO:0009952]; gene expression [GO:0010467]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]	anterior/posterior pattern specification [GO:0009952]; gene expression [GO:0010467]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]	chromatin binding [GO:0003682]; poly(A) RNA binding [GO:0044822]	catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]	GO:0008380; GO:0000375; GO:0005689; GO:0009952; GO:0071013; GO:0003682; GO:0010467; GO:0000398; GO:0016607; GO:0005654; GO:0005634; GO:0044822; GO:0005681	SUBCELLULAR LOCATION: Nucleus speckle. Note=During mitosis, transiently dispersed from the nuclear speckles to the cytoplasm.	3D-structure; Acetylation; Alternative splicing; Citrullination; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat; Spliceosome; mRNA processing; mRNA splicing	Alternative sequence (2); Beta strand (1); Chain (1); Helix (2); Modified residue (38); Mutagenesis (20); Region (3); Repeat (11); Sequence conflict (2)
NUCL_HUMAN	P19338	NUCL_HUMAN	reviewed	Nucleolin (Protein C23)	NCL	Homo sapiens (Human)	710	cell cortex [GO:0005938]; cytoplasmic ribonucleoprotein granule [GO:0036464]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]; identical protein binding [GO:0042802]; nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; protein C-terminus binding [GO:0008022]; RNA binding [GO:0003723]; telomeric DNA binding [GO:0042162]; angiogenesis [GO:0001525]; positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter [GO:1901838]	angiogenesis [GO:0001525]; positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter [GO:1901838]	identical protein binding [GO:0042802]; nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; protein C-terminus binding [GO:0008022]; RNA binding [GO:0003723]; telomeric DNA binding [GO:0042162]	cell cortex [GO:0005938]; cytoplasmic ribonucleoprotein granule [GO:0036464]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]	GO:0003723; GO:0001525; GO:0005938; GO:0036464; GO:0070062; GO:0042802; GO:0016020; GO:0005730; GO:0005654; GO:0000166; GO:0005634; GO:0044822; GO:1901838; GO:0008022; GO:0030529; GO:0042162	SUBCELLULAR LOCATION: Nucleus, nucleolus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.	3D-structure; Acetylation; Complete proteome; Cytoplasm; DNA-binding; Direct protein sequencing; Methylation; Nucleus; Phosphoprotein; Polymorphism; RNA-binding; Reference proteome; Repeat	Beta strand (23); Chain (1); Compositional bias (4); Domain (4); Helix (10); Initiator methionine (1); Modified residue (52); Natural variant (3); Region (1); Repeat (8); Sequence caution (1); Sequence conflict (3); Turn (1)
PYGB_HUMAN	P11216	PYGB_HUMAN	reviewed	Glycogen phosphorylase, brain form (EC 2.4.1.1)	PYGB	Homo sapiens (Human)	843	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; glycogen phosphorylase activity [GO:0008184]; pyridoxal phosphate binding [GO:0030170]; carbohydrate metabolic process [GO:0005975]; glucose metabolic process [GO:0006006]; glycogen catabolic process [GO:0005980]; small molecule metabolic process [GO:0044281]	carbohydrate metabolic process [GO:0005975]; glucose metabolic process [GO:0006006]; glycogen catabolic process [GO:0005980]; small molecule metabolic process [GO:0044281]	glycogen phosphorylase activity [GO:0008184]; pyridoxal phosphate binding [GO:0030170]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]	GO:0005975; GO:0005737; GO:0070062; GO:0006006; GO:0005980; GO:0008184; GO:0016020; GO:0030170; GO:0044281		Acetylation; Allosteric enzyme; Carbohydrate metabolism; Complete proteome; Direct protein sequencing; Glycogen metabolism; Glycosyltransferase; Phosphoprotein; Polymorphism; Pyridoxal phosphate; Reference proteome; Transferase	Binding site (1); Chain (1); Initiator methionine (1); Modified residue (5); Natural variant (2); Sequence conflict (5); Site (3)
PNMA2_HUMAN	Q9UL42	PNMA2_HUMAN	reviewed	Paraneoplastic antigen Ma2 (40 kDa neuronal protein) (Onconeuronal antigen Ma2) (Paraneoplastic neuronal antigen MM2)	PNMA2 KIAA0883 MA2	Homo sapiens (Human)	364	nucleolus [GO:0005730]; positive regulation of apoptotic process [GO:0043065]	positive regulation of apoptotic process [GO:0043065]		nucleolus [GO:0005730]	GO:0005730; GO:0043065	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:10050892}.	Acetylation; Complete proteome; Direct protein sequencing; Nucleus; Polymorphism; Reference proteome; Tumor antigen	Chain (1); Compositional bias (1); Erroneous initiation (1); Initiator methionine (1); Modified residue (1); Natural variant (1); Sequence conflict (4)
PSB5_HUMAN	P28074	PSB5_HUMAN	reviewed	Proteasome subunit beta type-5 (EC 3.4.25.1) (Macropain epsilon chain) (Multicatalytic endopeptidase complex epsilon chain) (Proteasome chain 6) (Proteasome epsilon chain) (Proteasome subunit MB1) (Proteasome subunit X)	PSMB5 LMPX MB1 X	Homo sapiens (Human)	263	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298]; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; response to oxidative stress [GO:0006979]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; response to oxidative stress [GO:0006979]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]	GO:0006977; GO:0000082; GO:0031145; GO:0042590; GO:0002479; GO:0002474; GO:0006915; GO:0034641; GO:0005813; GO:0005737; GO:0005829; GO:0004175; GO:0070062; GO:0010467; GO:0045087; GO:0000278; GO:0043066; GO:0090090; GO:0051436; GO:0005654; GO:0005634; GO:0090263; GO:0051437; GO:0012501; GO:0010499; GO:0000502; GO:0005839; GO:0043161; GO:0000209; GO:0042981; GO:0006521; GO:0051439; GO:0006979; GO:0044281; GO:0002223; GO:0004298; GO:0016032	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.	3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Host-virus interaction; Hydrolase; Nucleus; Polymorphism; Protease; Proteasome; Reference proteome; Threonine protease; Zymogen	Active site (1); Alternative sequence (2); Beta strand (12); Binding site (1); Chain (1); Erroneous initiation (3); Helix (5); Mutagenesis (3); Natural variant (1); Propeptide (1); Sequence conflict (5); Turn (1)
IAH1_HUMAN	Q2TAA2	IAH1_HUMAN	reviewed	Isoamyl acetate-hydrolyzing esterase 1 homolog (EC 3.1.-.-)	IAH1	Homo sapiens (Human)	248	extracellular exosome [GO:0070062]; hydrolase activity, acting on ester bonds [GO:0016788]; lipid catabolic process [GO:0016042]	lipid catabolic process [GO:0016042]	hydrolase activity, acting on ester bonds [GO:0016788]	extracellular exosome [GO:0070062]	GO:0070062; GO:0016788; GO:0016042		Alternative splicing; Complete proteome; Hydrolase; Lipid degradation; Lipid metabolism; Reference proteome	Active site (3); Alternative sequence (1); Binding site (2); Chain (1); Modified residue (1)
XRCC5_HUMAN	P13010	XRCC5_HUMAN	reviewed	X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining))	XRCC5 G22P2	Homo sapiens (Human)	732	cytosol [GO:0005829]; Ku70:Ku80 complex [GO:0043564]; membrane [GO:0016020]; nonhomologous end joining complex [GO:0070419]; nuclear chromosome, telomeric region [GO:0000784]; nuclear telomere cap complex [GO:0000783]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATP-dependent DNA helicase activity [GO:0004003]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; poly(A) RNA binding [GO:0044822]; protein C-terminus binding [GO:0008022]; telomeric DNA binding [GO:0042162]; transcription regulatory region DNA binding [GO:0044212]; ubiquitin protein ligase binding [GO:0031625]; brain development [GO:0007420]; cell proliferation [GO:0008283]; cellular hyperosmotic salinity response [GO:0071475]; cellular response to fatty acid [GO:0071398]; cellular response to X-ray [GO:0071481]; DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; establishment of integrated proviral latency [GO:0075713]; hematopoietic stem cell differentiation [GO:0060218]; innate immune response [GO:0045087]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of neurogenesis [GO:0050769]; positive regulation of type I interferon production [GO:0032481]; response to drug [GO:0042493]; telomere maintenance [GO:0000723]; transcription, DNA-templated [GO:0006351]; viral process [GO:0016032]	brain development [GO:0007420]; cell proliferation [GO:0008283]; cellular hyperosmotic salinity response [GO:0071475]; cellular response to fatty acid [GO:0071398]; cellular response to X-ray [GO:0071481]; DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; establishment of integrated proviral latency [GO:0075713]; hematopoietic stem cell differentiation [GO:0060218]; innate immune response [GO:0045087]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of neurogenesis [GO:0050769]; positive regulation of type I interferon production [GO:0032481]; response to drug [GO:0042493]; telomere maintenance [GO:0000723]; transcription, DNA-templated [GO:0006351]; viral process [GO:0016032]	ATP binding [GO:0005524]; ATP-dependent DNA helicase activity [GO:0004003]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; poly(A) RNA binding [GO:0044822]; protein C-terminus binding [GO:0008022]; telomeric DNA binding [GO:0042162]; transcription regulatory region DNA binding [GO:0044212]; ubiquitin protein ligase binding [GO:0031625]	cytosol [GO:0005829]; Ku70:Ku80 complex [GO:0043564]; membrane [GO:0016020]; nonhomologous end joining complex [GO:0070419]; nuclear chromosome, telomeric region [GO:0000784]; nuclear telomere cap complex [GO:0000783]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005524; GO:0004003; GO:0003677; GO:0032508; GO:0006310; GO:0006281; GO:0043564; GO:0007420; GO:0008283; GO:0071475; GO:0071481; GO:0071398; GO:0005829; GO:0003684; GO:0006302; GO:0006303; GO:0003690; GO:0075713; GO:0060218; GO:0045087; GO:0016020; GO:0045892; GO:0070419; GO:0000784; GO:0000783; GO:0005730; GO:0005654; GO:0005634; GO:0005886; GO:0044822; GO:0050769; GO:0032481; GO:0008022; GO:0042493; GO:0000723; GO:0042162; GO:0044212; GO:0006351; GO:0031625; GO:0016032	SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus. Chromosome.	3D-structure; ATP-binding; Acetylation; Activator; Chromosome; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA-binding; Direct protein sequencing; Helicase; Hydrolase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Systemic lupus erythematosus; Transcription; Transcription regulation; Ubl conjugation	Beta strand (27); Chain (1); Compositional bias (1); Domain (1); Helix (27); Initiator methionine (1); Modified residue (9); Motif (1); Mutagenesis (2); Natural variant (2); Region (1); Sequence conflict (8); Turn (8)
PRS8_HUMAN	P62195	PRS8_HUMAN	reviewed	26S protease regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)	PSMC5 SUG1	Homo sapiens (Human)	406	blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; cytosolic proteasome complex [GO:0031597]; extracellular exosome [GO:0070062]; inclusion body [GO:0016234]; membrane [GO:0016020]; nuclear proteasome complex [GO:0031595]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; proteasome-activating ATPase activity [GO:0036402]; TBP-class protein binding [GO:0017025]; thyrotropin-releasing hormone receptor binding [GO:0031531]; transcription cofactor activity [GO:0003712]; transcription factor binding [GO:0008134]; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of programmed cell death [GO:0043069]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of inclusion body assembly [GO:0090261]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [GO:0045899]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; transcription from RNA polymerase II promoter [GO:0006366]; viral process [GO:0016032]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of programmed cell death [GO:0043069]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of inclusion body assembly [GO:0090261]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [GO:0045899]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; transcription from RNA polymerase II promoter [GO:0006366]; viral process [GO:0016032]	ATPase activity [GO:0016887]; ATP binding [GO:0005524]; proteasome-activating ATPase activity [GO:0036402]; TBP-class protein binding [GO:0017025]; thyrotropin-releasing hormone receptor binding [GO:0031531]; transcription cofactor activity [GO:0003712]; transcription factor binding [GO:0008134]	blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; cytosolic proteasome complex [GO:0031597]; extracellular exosome [GO:0070062]; inclusion body [GO:0016234]; membrane [GO:0016020]; nuclear proteasome complex [GO:0031595]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]	GO:0005524; GO:0016887; GO:0006977; GO:0030433; GO:0000082; GO:0017025; GO:0031145; GO:0042590; GO:0002479; GO:0002474; GO:0006915; GO:0072562; GO:0034641; GO:0005737; GO:0031410; GO:0005829; GO:0031597; GO:0070062; GO:0010467; GO:0016234; GO:0045087; GO:0016020; GO:0000278; GO:0043066; GO:0090090; GO:0043069; GO:0045892; GO:0051436; GO:0031595; GO:0005654; GO:0005634; GO:0045899; GO:0090263; GO:0090261; GO:1901800; GO:0045893; GO:0051437; GO:0012501; GO:0022624; GO:0000502; GO:0008540; GO:0036402; GO:0043161; GO:0000209; GO:0042981; GO:0006521; GO:0051439; GO:0044281; GO:0002223; GO:0031531; GO:0003712; GO:0008134; GO:0006366; GO:0016032	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.	3D-structure; ATP-binding; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Nucleotide-binding; Nucleus; Polymorphism; Proteasome; Reference proteome	Alternative sequence (1); Beta strand (2); Chain (1); Helix (4); Initiator methionine (1); Modified residue (2); Natural variant (2); Nucleotide binding (1); Region (1); Sequence conflict (5)
SPT4H_HUMAN	P63272	SPT4H_HUMAN	reviewed	Transcription elongation factor SPT4 (hSPT4) (DRB sensitivity-inducing factor 14 kDa subunit) (DSIF p14) (DRB sensitivity-inducing factor small subunit) (DSIF small subunit)	SUPT4H1 SPT4H SUPT4H	Homo sapiens (Human)	117	DSIF complex [GO:0032044]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein heterodimerization activity [GO:0046982]; sequence-specific DNA binding transcription factor activity [GO:0003700]; zinc ion binding [GO:0008270]; chromatin remodeling [GO:0006338]; gene expression [GO:0010467]; negative regulation of DNA-templated transcription, elongation [GO:0032785]; negative regulation of transcription elongation from RNA polymerase II promoter [GO:0034244]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of viral transcription [GO:0050434]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; regulation of transcription, DNA-templated [GO:0006355]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]; viral process [GO:0016032]	chromatin remodeling [GO:0006338]; gene expression [GO:0010467]; negative regulation of DNA-templated transcription, elongation [GO:0032785]; negative regulation of transcription elongation from RNA polymerase II promoter [GO:0034244]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of viral transcription [GO:0050434]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]; viral process [GO:0016032]	protein heterodimerization activity [GO:0046982]; sequence-specific DNA binding transcription factor activity [GO:0003700]; zinc ion binding [GO:0008270]	DSIF complex [GO:0032044]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0032044; GO:0006338; GO:0010467; GO:0032785; GO:0034244; GO:0000122; GO:0005654; GO:0005634; GO:0032786; GO:0045944; GO:0050434; GO:0046982; GO:0006357; GO:0006355; GO:0003700; GO:0006368; GO:0006366; GO:0016032; GO:0008270	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8649394}.	3D-structure; Acetylation; Activator; Complete proteome; Metal-binding; Nucleus; Reference proteome; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger	Beta strand (6); Chain (1); Helix (7); Initiator methionine (1); Modified residue (1); Region (1); Sequence conflict (1); Turn (2); Zinc finger (1)
MYL6_HUMAN	P60660	MYL6_HUMAN	reviewed	Myosin light polypeptide 6 (17 kDa myosin light chain) (LC17) (Myosin light chain 3) (MLC-3) (Myosin light chain alkali 3) (Myosin light chain A3) (Smooth muscle and nonmuscle myosin light chain alkali 6)	MYL6	Homo sapiens (Human)	151	brush border [GO:0005903]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; myosin complex [GO:0016459]; unconventional myosin complex [GO:0016461]; vesicle [GO:0031982]; actin-dependent ATPase activity [GO:0030898]; calcium ion binding [GO:0005509]; motor activity [GO:0003774]; structural constituent of muscle [GO:0008307]; axon guidance [GO:0007411]; ephrin receptor signaling pathway [GO:0048013]; metabolic process [GO:0008152]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; skeletal muscle tissue development [GO:0007519]; small GTPase mediated signal transduction [GO:0007264]	axon guidance [GO:0007411]; ephrin receptor signaling pathway [GO:0048013]; metabolic process [GO:0008152]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; skeletal muscle tissue development [GO:0007519]; small GTPase mediated signal transduction [GO:0007264]	actin-dependent ATPase activity [GO:0030898]; calcium ion binding [GO:0005509]; motor activity [GO:0003774]; structural constituent of muscle [GO:0008307]	brush border [GO:0005903]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; myosin complex [GO:0016459]; unconventional myosin complex [GO:0016461]; vesicle [GO:0031982]	GO:0030898; GO:0007411; GO:0005903; GO:0005509; GO:0005829; GO:0048013; GO:0070062; GO:0016020; GO:0008152; GO:0003774; GO:0006936; GO:0030049; GO:0016459; GO:0007519; GO:0007264; GO:0008307; GO:0016461; GO:0031982		Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Motor protein; Muscle protein; Myosin; Phosphoprotein; Polymorphism; Reference proteome; Repeat	Alternative sequence (1); Chain (1); Domain (3); Initiator methionine (1); Modified residue (3); Natural variant (2); Sequence conflict (3)
TCPD_HUMAN	P50991	TCPD_HUMAN	reviewed	T-complex protein 1 subunit delta (TCP-1-delta) (CCT-delta) (Stimulator of TAR RNA-binding)	CCT4 CCTD SRB	Homo sapiens (Human)	539	cell body [GO:0044297]; centrosome [GO:0005813]; chaperonin-containing T-complex [GO:0005832]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; zona pellucida receptor complex [GO:0002199]; ATP binding [GO:0005524]; poly(A) RNA binding [GO:0044822]; unfolded protein binding [GO:0051082]; 'de novo' posttranslational protein folding [GO:0051084]; binding of sperm to zona pellucida [GO:0007339]; cellular protein metabolic process [GO:0044267]; protein folding [GO:0006457]; toxin transport [GO:1901998]	'de novo' posttranslational protein folding [GO:0051084]; binding of sperm to zona pellucida [GO:0007339]; cellular protein metabolic process [GO:0044267]; protein folding [GO:0006457]; toxin transport [GO:1901998]	ATP binding [GO:0005524]; poly(A) RNA binding [GO:0044822]; unfolded protein binding [GO:0051082]	cell body [GO:0044297]; centrosome [GO:0005813]; chaperonin-containing T-complex [GO:0005832]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; zona pellucida receptor complex [GO:0002199]	GO:0051084; GO:0005524; GO:0007339; GO:0044297; GO:0044267; GO:0005813; GO:0005832; GO:0005737; GO:0005829; GO:0070062; GO:0042470; GO:0005874; GO:0005654; GO:0044822; GO:0006457; GO:1901998; GO:0051082; GO:0002199	SUBCELLULAR LOCATION: Cytoplasm. Melanosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.	ATP-binding; Acetylation; Alternative splicing; Chaperone; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Nucleotide-binding; Polymorphism; Reference proteome	Alternative sequence (1); Chain (1); Initiator methionine (1); Modified residue (5); Natural variant (1); Sequence conflict (2)
MCM7_HUMAN	P33993	MCM7_HUMAN	reviewed	DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3)	MCM7 CDC47 MCM2	Homo sapiens (Human)	719	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; MCM complex [GO:0042555]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; DNA helicase activity [GO:0003678]; single-stranded DNA binding [GO:0003697]; cell proliferation [GO:0008283]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to epidermal growth factor stimulus [GO:0071364]; DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA unwinding involved in DNA replication [GO:0006268]; G1/S transition of mitotic cell cycle [GO:0000082]; mitotic cell cycle [GO:0000278]; regulation of phosphorylation [GO:0042325]; response to drug [GO:0042493]	cell proliferation [GO:0008283]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to epidermal growth factor stimulus [GO:0071364]; DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA unwinding involved in DNA replication [GO:0006268]; G1/S transition of mitotic cell cycle [GO:0000082]; mitotic cell cycle [GO:0000278]; regulation of phosphorylation [GO:0042325]; response to drug [GO:0042493]	ATP binding [GO:0005524]; DNA helicase activity [GO:0003678]; single-stranded DNA binding [GO:0003697]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; MCM complex [GO:0042555]; membrane [GO:0016020]; nucleoplasm [GO:0005654]	GO:0005524; GO:0003678; GO:0006260; GO:0006270; GO:0006271; GO:0006268; GO:0000082; GO:0042555; GO:0008283; GO:0006974; GO:0071364; GO:0000785; GO:0005737; GO:0005829; GO:0016020; GO:0000278; GO:0005654; GO:0042325; GO:0042493; GO:0003697	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.	ATP-binding; Acetylation; Alternative splicing; Cell cycle; Complete proteome; DNA replication; DNA-binding; Direct protein sequencing; Glycoprotein; Helicase; Hydrolase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome	Alternative sequence (2); Chain (1); Domain (1); Initiator methionine (1); Modified residue (4); Motif (1); Natural variant (3); Nucleotide binding (1); Region (2); Sequence conflict (1)
PSB8_HUMAN	P28062	PSB8_HUMAN	reviewed	Proteasome subunit beta type-8 (EC 3.4.25.1) (Low molecular mass protein 7) (Macropain subunit C13) (Multicatalytic endopeptidase complex subunit C13) (Proteasome component C13) (Proteasome subunit beta-5i) (Really interesting new gene 10 protein)	PSMB8 LMP7 PSMB5i RING10 Y2	Homo sapiens (Human)	276	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; spermatoproteasome complex [GO:1990111]; endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298]; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; cytokine-mediated signaling pathway [GO:0019221]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; fat cell differentiation [GO:0045444]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; type I interferon signaling pathway [GO:0060337]; viral process [GO:0016032]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; cytokine-mediated signaling pathway [GO:0019221]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; fat cell differentiation [GO:0045444]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; type I interferon signaling pathway [GO:0060337]; viral process [GO:0016032]	endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; spermatoproteasome complex [GO:1990111]	GO:0006977; GO:0000082; GO:0031145; GO:0042590; GO:0002479; GO:0002474; GO:0006915; GO:0034641; GO:0019221; GO:0005737; GO:0005829; GO:0004175; GO:0070062; GO:0045444; GO:0010467; GO:0045087; GO:0000278; GO:0043066; GO:0090090; GO:0051436; GO:0005654; GO:0090263; GO:0051437; GO:0012501; GO:0010499; GO:0000502; GO:0005839; GO:0043161; GO:0000209; GO:0042981; GO:0006521; GO:0051439; GO:0044281; GO:1990111; GO:0002223; GO:0004298; GO:0060337; GO:0016032	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00809}. Nucleus {ECO:0000250}.	Alternative splicing; Complete proteome; Cytoplasm; Differentiation; Disease mutation; Host-virus interaction; Hydrolase; Immunity; Nucleus; Phosphoprotein; Polymorphism; Protease; Proteasome; Reference proteome; Threonine protease; Zymogen	Active site (1); Alternative sequence (1); Chain (1); Natural variant (6); Propeptide (1); Site (1)
EF2_HUMAN	P13639	EF2_HUMAN	reviewed	Elongation factor 2 (EF-2)	EEF2 EF2	Homo sapiens (Human)	858	aggresome [GO:0016235]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; polysome [GO:0005844]; ribonucleoprotein complex [GO:0030529]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; poly(A) RNA binding [GO:0044822]; protein kinase binding [GO:0019901]; translation elongation factor activity [GO:0003746]; cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; hematopoietic progenitor cell differentiation [GO:0002244]; peptidyl-diphthamide biosynthetic process from peptidyl-histidine [GO:0017183]; positive regulation of translation [GO:0045727]; post-translational protein modification [GO:0043687]; translation [GO:0006412]; translational elongation [GO:0006414]	cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; hematopoietic progenitor cell differentiation [GO:0002244]; peptidyl-diphthamide biosynthetic process from peptidyl-histidine [GO:0017183]; positive regulation of translation [GO:0045727]; post-translational protein modification [GO:0043687]; translation [GO:0006412]; translational elongation [GO:0006414]	GTPase activity [GO:0003924]; GTP binding [GO:0005525]; poly(A) RNA binding [GO:0044822]; protein kinase binding [GO:0019901]; translation elongation factor activity [GO:0003746]	aggresome [GO:0016235]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; polysome [GO:0005844]; ribonucleoprotein complex [GO:0030529]	GO:0005525; GO:0003924; GO:0016235; GO:0044267; GO:0005737; GO:0005829; GO:0070062; GO:0010467; GO:0002244; GO:0016020; GO:0005634; GO:0017183; GO:0005886; GO:0044822; GO:0005844; GO:0045727; GO:0043687; GO:0019901; GO:0030529; GO:0006412; GO:0003746; GO:0006414	SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000269|PubMed:24648518}. Note=Phosphorylation by CSK promotes cleavage and SUMOylation-dependent nuclear translocation of the C-terminal cleavage product. {ECO:0000269|PubMed:24648518}.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Elongation factor; GTP-binding; Isopeptide bond; Methylation; Neurodegeneration; Nucleotide-binding; Nucleus; Phosphoprotein; Protein biosynthesis; Reference proteome; Spinocerebellar ataxia; Ubl conjugation	Chain (1); Cross-link (2); Domain (1); Initiator methionine (1); Modified residue (20); Mutagenesis (2); Natural variant (1); Nucleotide binding (3); Site (2)
TBCB_HUMAN	Q99426	TBCB_HUMAN	reviewed	Tubulin-folding cofactor B (Cytoskeleton-associated protein 1) (Cytoskeleton-associated protein CKAPI) (Tubulin-specific chaperone B)	TBCB CG22 CKAP1	Homo sapiens (Human)	244	cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; 'de novo' posttranslational protein folding [GO:0051084]; cell differentiation [GO:0030154]; cellular protein metabolic process [GO:0044267]; nervous system development [GO:0007399]	'de novo' posttranslational protein folding [GO:0051084]; cell differentiation [GO:0030154]; cellular protein metabolic process [GO:0044267]; nervous system development [GO:0007399]		cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]	GO:0051084; GO:0030154; GO:0044267; GO:0005737; GO:0005874; GO:0015630; GO:0007399; GO:0005654	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15831477}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15831477}. Note=Colocalizes with microtubules. In differentiated neurons, located in the cytoplasm. In differentiating neurons, accumulates at the growth cone.	Acetylation; Alternative splicing; Chaperone; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Differentiation; Microtubule; Neurogenesis; Phosphoprotein; Reference proteome; Ubl conjugation	Alternative sequence (1); Chain (1); Domain (1); Erroneous gene model prediction (1); Modified residue (6); Mutagenesis (2); Sequence conflict (1)
IF4G1_HUMAN	Q04637	IF4G1_HUMAN	reviewed	Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220)	EIF4G1 EIF4F EIF4G EIF4GI	Homo sapiens (Human)	1599	cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; membrane [GO:0016020]; poly(A) RNA binding [GO:0044822]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]; cellular protein metabolic process [GO:0044267]; cytokine-mediated signaling pathway [GO:0019221]; gene expression [GO:0010467]; insulin receptor signaling pathway [GO:0008286]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; regulation of translational initiation [GO:0006446]; translation [GO:0006412]; translational initiation [GO:0006413]; viral process [GO:0016032]	cellular protein metabolic process [GO:0044267]; cytokine-mediated signaling pathway [GO:0019221]; gene expression [GO:0010467]; insulin receptor signaling pathway [GO:0008286]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; regulation of translational initiation [GO:0006446]; translation [GO:0006412]; translational initiation [GO:0006413]; viral process [GO:0016032]	poly(A) RNA binding [GO:0044822]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]	cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; membrane [GO:0016020]	GO:0044267; GO:0019221; GO:0005829; GO:0016281; GO:0010467; GO:0008286; GO:0016020; GO:0000288; GO:0000184; GO:0000289; GO:0044822; GO:0006446; GO:0006412; GO:0008135; GO:0003743; GO:0006413; GO:0016032		3D-structure; Acetylation; Alternative initiation; Alternative splicing; Complete proteome; Disease mutation; Host-virus interaction; Initiation factor; Neurodegeneration; Parkinson disease; Parkinsonism; Phosphoprotein; Polymorphism; Protein biosynthesis; RNA-binding; Reference proteome; Translation regulation	Alternative sequence (6); Beta strand (2); Chain (1); Compositional bias (2); Domain (3); Erroneous initiation (2); Frameshift (1); Helix (26); Modified residue (16); Mutagenesis (21); Natural variant (16); Region (5); Sequence caution (1); Sequence conflict (25); Site (2); Turn (3)
EZRI_HUMAN	P15311	EZRI_HUMAN	reviewed	Ezrin (Cytovillin) (Villin-2) (p81)	EZR VIL2	Homo sapiens (Human)	586	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; astrocyte projection [GO:0097449]; basolateral plasma membrane [GO:0016323]; brush border [GO:0005903]; cell body [GO:0044297]; cell periphery [GO:0071944]; cell tip [GO:0051286]; ciliary basal body [GO:0036064]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytoplasmic side of apical plasma membrane [GO:0098592]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; extrinsic component of membrane [GO:0019898]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; membrane [GO:0016020]; membrane raft [GO:0045121]; microspike [GO:0044393]; microvillus [GO:0005902]; microvillus membrane [GO:0031528]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; Schwann cell microvillus [GO:0097454]; T-tubule [GO:0030315]; uropod [GO:0001931]; vesicle [GO:0031982]; actin filament binding [GO:0051015]; cell adhesion molecule binding [GO:0050839]; poly(A) RNA binding [GO:0044822]; actin cytoskeleton reorganization [GO:0031532]; actin filament bundle assembly [GO:0051017]; axon guidance [GO:0007411]; cytoskeletal anchoring at plasma membrane [GO:0007016]; establishment of endothelial barrier [GO:0061028]; establishment or maintenance of apical/basal cell polarity [GO:0035088]; filopodium assembly [GO:0046847]; leukocyte cell-cell adhesion [GO:0007159]; membrane to membrane docking [GO:0022614]; microvillus assembly [GO:0030033]; phosphatidylinositol-mediated signaling [GO:0048015]; positive regulation of cellular protein catabolic process [GO:1903364]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of gene expression [GO:0010628]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of protein secretion [GO:0050714]; receptor internalization [GO:0031623]; regulation of cell shape [GO:0008360]; regulation of organelle assembly [GO:1902115]; sphingosine-1-phosphate signaling pathway [GO:0003376]	actin cytoskeleton reorganization [GO:0031532]; actin filament bundle assembly [GO:0051017]; axon guidance [GO:0007411]; cytoskeletal anchoring at plasma membrane [GO:0007016]; establishment of endothelial barrier [GO:0061028]; establishment or maintenance of apical/basal cell polarity [GO:0035088]; filopodium assembly [GO:0046847]; leukocyte cell-cell adhesion [GO:0007159]; membrane to membrane docking [GO:0022614]; microvillus assembly [GO:0030033]; phosphatidylinositol-mediated signaling [GO:0048015]; positive regulation of cellular protein catabolic process [GO:1903364]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of gene expression [GO:0010628]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of protein secretion [GO:0050714]; receptor internalization [GO:0031623]; regulation of cell shape [GO:0008360]; regulation of organelle assembly [GO:1902115]; sphingosine-1-phosphate signaling pathway [GO:0003376]	actin filament binding [GO:0051015]; cell adhesion molecule binding [GO:0050839]; poly(A) RNA binding [GO:0044822]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; astrocyte projection [GO:0097449]; basolateral plasma membrane [GO:0016323]; brush border [GO:0005903]; cell body [GO:0044297]; cell periphery [GO:0071944]; cell tip [GO:0051286]; ciliary basal body [GO:0036064]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytoplasmic side of apical plasma membrane [GO:0098592]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; extrinsic component of membrane [GO:0019898]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; membrane [GO:0016020]; membrane raft [GO:0045121]; microspike [GO:0044393]; microvillus [GO:0005902]; microvillus membrane [GO:0031528]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; Schwann cell microvillus [GO:0097454]; T-tubule [GO:0030315]; uropod [GO:0001931]; vesicle [GO:0031982]	GO:0097454; GO:0030315; GO:0015629; GO:0031532; GO:0005884; GO:0051015; GO:0051017; GO:0045177; GO:0016324; GO:0097449; GO:0007411; GO:0016323; GO:0005903; GO:0050839; GO:0044297; GO:0071944; GO:0051286; GO:0036064; GO:0030863; GO:0005737; GO:0098592; GO:0007016; GO:0005829; GO:0005768; GO:0061028; GO:0035088; GO:0070062; GO:0005615; GO:0019898; GO:0030175; GO:0046847; GO:0005925; GO:0007159; GO:0016020; GO:0045121; GO:0022614; GO:0044393; GO:0005902; GO:0030033; GO:0031528; GO:0005730; GO:0048015; GO:0005886; GO:0044822; GO:1903364; GO:2000643; GO:0010628; GO:1902966; GO:0050714; GO:0031623; GO:0008360; GO:1902115; GO:0001726; GO:0032587; GO:0003376; GO:0001931; GO:0031982	SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:18046454}; Peripheral membrane protein {ECO:0000269|PubMed:18046454}; Cytoplasmic side {ECO:0000269|PubMed:18046454}. Cell projection {ECO:0000269|PubMed:18046454}. Cell projection, microvillus membrane {ECO:0000269|PubMed:18046454}; Peripheral membrane protein {ECO:0000269|PubMed:18046454}; Cytoplasmic side {ECO:0000269|PubMed:18046454}. Cell projection, ruffle membrane {ECO:0000269|PubMed:18046454}; Peripheral membrane protein {ECO:0000269|PubMed:18046454}; Cytoplasmic side {ECO:0000269|PubMed:18046454}. Cytoplasm, cell cortex {ECO:0000269|PubMed:18046454}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18046454}. Note=Localization to the apical membrane of parietal cells depends on the interaction with MPP5. Localizes to cell extensions and peripheral processes of astrocytes (By similarity). Microvillar peripheral membrane protein (cytoplasmic side). {ECO:0000250}.	3D-structure; Acetylation; Cell membrane; Cell projection; Cell shape; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Membrane; Phosphoprotein; Polymorphism; Reference proteome; S-nitrosylation	Beta strand (15); Chain (1); Domain (1); Erroneous initiation (2); Helix (10); Initiator methionine (1); Modified residue (9); Motif (1); Natural variant (3); Region (1); Turn (2)
TRM11_HUMAN	Q7Z4G4	TRM11_HUMAN	reviewed	tRNA (guanine(10)-N2)-methyltransferase homolog (EC 2.1.1.-) (tRNA guanosine-2'-O-methyltransferase TRM11 homolog)	TRMT11 C6orf75 MDS024	Homo sapiens (Human)	463	methyltransferase activity [GO:0008168]; tRNA binding [GO:0000049]; tRNA processing [GO:0008033]	tRNA processing [GO:0008033]	methyltransferase activity [GO:0008168]; tRNA binding [GO:0000049]		GO:0008168; GO:0000049; GO:0008033		Acetylation; Alternative splicing; Complete proteome; Methyltransferase; Polymorphism; RNA-binding; Reference proteome; S-adenosyl-L-methionine; Transferase; tRNA processing; tRNA-binding	Alternative sequence (3); Chain (1); Initiator methionine (1); Modified residue (1); Natural variant (1)
VATE1_HUMAN	P36543	VATE1_HUMAN	reviewed	V-type proton ATPase subunit E 1 (V-ATPase subunit E 1) (V-ATPase 31 kDa subunit) (p31) (Vacuolar proton pump subunit E 1)	ATP6V1E1 ATP6E ATP6E2	Homo sapiens (Human)	226	apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; microvillus [GO:0005902]; mitochondrion [GO:0005739]; proton-transporting two-sector ATPase complex [GO:0016469]; proton-transporting two-sector ATPase complex, catalytic domain [GO:0033178]; ATPase binding [GO:0051117]; hydrogen-exporting ATPase activity, phosphorylative mechanism [GO:0008553]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; ATP hydrolysis coupled proton transport [GO:0015991]; cellular iron ion homeostasis [GO:0006879]; insulin receptor signaling pathway [GO:0008286]; interaction with host [GO:0051701]; ion transmembrane transport [GO:0034220]; phagosome maturation [GO:0090382]; proton transport [GO:0015992]; transferrin transport [GO:0033572]; transmembrane transport [GO:0055085]	ATP hydrolysis coupled proton transport [GO:0015991]; cellular iron ion homeostasis [GO:0006879]; insulin receptor signaling pathway [GO:0008286]; interaction with host [GO:0051701]; ion transmembrane transport [GO:0034220]; phagosome maturation [GO:0090382]; proton transport [GO:0015992]; transferrin transport [GO:0033572]; transmembrane transport [GO:0055085]	ATPase binding [GO:0051117]; hydrogen-exporting ATPase activity, phosphorylative mechanism [GO:0008553]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]	apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; microvillus [GO:0005902]; mitochondrion [GO:0005739]; proton-transporting two-sector ATPase complex [GO:0016469]; proton-transporting two-sector ATPase complex, catalytic domain [GO:0033178]	GO:0015991; GO:0051117; GO:0016324; GO:0006879; GO:0005829; GO:0005768; GO:0070062; GO:0008553; GO:0008286; GO:0051701; GO:0034220; GO:0005765; GO:0005902; GO:0005739; GO:0090382; GO:0015992; GO:0046961; GO:0016469; GO:0033178; GO:0033572; GO:0055085		Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Hydrogen ion transport; Hydrolase; Ion transport; Phosphoprotein; Polymorphism; Reference proteome; Transport	Alternative sequence (2); Chain (1); Initiator methionine (1); Modified residue (2); Natural variant (1); Sequence conflict (2)
KCC4_HUMAN	Q16566	KCC4_HUMAN	reviewed	Calcium/calmodulin-dependent protein kinase type IV (CaMK IV) (EC 2.7.11.17) (CaM kinase-GR)	CAMK4 CAMK CAMK-GR CAMKIV	Homo sapiens (Human)	473	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; calcium-dependent protein serine/threonine kinase activity [GO:0009931]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; activation of phospholipase C activity [GO:0007202]; epidermal growth factor receptor signaling pathway [GO:0007173]; fibroblast growth factor receptor signaling pathway [GO:0008543]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; long-term memory [GO:0007616]; myeloid dendritic cell differentiation [GO:0043011]; neuron-neuron synaptic transmission [GO:0007270]; neurotrophin TRK receptor signaling pathway [GO:0048011]; nucleocytoplasmic transport [GO:0006913]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of transcription, DNA-templated [GO:0045893]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of osteoclast differentiation [GO:0045670]; regulation of T cell differentiation in thymus [GO:0033081]; signal transduction [GO:0007165]; synaptic transmission [GO:0007268]	activation of phospholipase C activity [GO:0007202]; epidermal growth factor receptor signaling pathway [GO:0007173]; fibroblast growth factor receptor signaling pathway [GO:0008543]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; long-term memory [GO:0007616]; myeloid dendritic cell differentiation [GO:0043011]; neuron-neuron synaptic transmission [GO:0007270]; neurotrophin TRK receptor signaling pathway [GO:0048011]; nucleocytoplasmic transport [GO:0006913]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of transcription, DNA-templated [GO:0045893]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of osteoclast differentiation [GO:0045670]; regulation of T cell differentiation in thymus [GO:0033081]; signal transduction [GO:0007165]; synaptic transmission [GO:0007268]	ATP binding [GO:0005524]; calcium-dependent protein serine/threonine kinase activity [GO:0009931]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	GO:0005524; GO:0007202; GO:0009931; GO:0005516; GO:0004683; GO:0005737; GO:0005829; GO:0007173; GO:0070062; GO:0008543; GO:0006954; GO:0045087; GO:0035556; GO:0007616; GO:0043011; GO:0007270; GO:0048011; GO:0006913; GO:0005730; GO:0005654; GO:0018105; GO:0046827; GO:0045893; GO:0046777; GO:0006468; GO:0033081; GO:0045670; GO:0007165; GO:0007268	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Localized in hippocampal neuron nuclei. In spermatids, associated with chromatin and nuclear matrix (By similarity). {ECO:0000250}.	3D-structure; ATP-binding; Adaptive immunity; Calcium; Calmodulin-binding; Complete proteome; Cytoplasm; Glycoprotein; Immunity; Inflammatory response; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase	Active site (1); Beta strand (8); Binding site (1); Chain (1); Domain (1); Erroneous initiation (1); Glycosylation (7); Helix (13); Modified residue (5); Mutagenesis (8); Natural variant (4); Nucleotide binding (1); Region (3); Turn (3)
THMS1_HUMAN	Q8N1K5	THMS1_HUMAN	reviewed	Protein THEMIS (Thymocyte-expressed molecule involved in selection)	THEMIS C6orf190 C6orf207	Homo sapiens (Human)	641	cell-cell junction [GO:0005911]; COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; negative T cell selection [GO:0043383]; positive T cell selection [GO:0043368]; T cell receptor signaling pathway [GO:0050852]	negative T cell selection [GO:0043383]; positive T cell selection [GO:0043368]; T cell receptor signaling pathway [GO:0050852]		cell-cell junction [GO:0005911]; COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0008180; GO:0050852; GO:0005911; GO:0005737; GO:0043383; GO:0005634; GO:0043368	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.	Adaptive immunity; Alternative splicing; Complete proteome; Cytoplasm; Developmental protein; Immunity; Nucleus; Phosphoprotein; Polymorphism; Reference proteome	Alternative sequence (3); Chain (1); Erroneous gene model prediction (2); Erroneous initiation (1); Modified residue (1); Natural variant (2); Region (2); Sequence caution (1); Sequence conflict (5)
UBP14_HUMAN	P54578	UBP14_HUMAN	reviewed	Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14)	USP14 TGT	Homo sapiens (Human)	494	cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic membrane-bounded vesicle [GO:0016023]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; proteasome complex [GO:0000502]; synapse [GO:0045202]; cysteine-type endopeptidase activity [GO:0004197]; endopeptidase inhibitor activity [GO:0004866]; proteasome binding [GO:0070628]; tRNA guanylyltransferase activity [GO:0008193]; ubiquitin-specific protease activity [GO:0004843]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903070]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; regulation of chemotaxis [GO:0050920]; regulation of proteasomal protein catabolic process [GO:0061136]; synaptic transmission [GO:0007268]	negative regulation of endopeptidase activity [GO:0010951]; negative regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903070]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; regulation of chemotaxis [GO:0050920]; regulation of proteasomal protein catabolic process [GO:0061136]; synaptic transmission [GO:0007268]	cysteine-type endopeptidase activity [GO:0004197]; endopeptidase inhibitor activity [GO:0004866]; proteasome binding [GO:0070628]; tRNA guanylyltransferase activity [GO:0008193]; ubiquitin-specific protease activity [GO:0004843]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic membrane-bounded vesicle [GO:0016023]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; proteasome complex [GO:0000502]; synapse [GO:0045202]	GO:0009986; GO:0004197; GO:0005737; GO:0016023; GO:0004866; GO:0070062; GO:1903070; GO:0010951; GO:0005634; GO:0005886; GO:0070628; GO:0000502; GO:0043161; GO:0016579; GO:0050920; GO:0061136; GO:0045202; GO:0007268; GO:0008193; GO:0004843	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19106094}. Cell membrane {ECO:0000269|PubMed:19106094}; Peripheral membrane protein {ECO:0000269|PubMed:19106094}.	3D-structure; Acetylation; Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Hydrolase; Membrane; Phosphoprotein; Protease; Proteasome; Reference proteome; Thiol protease; Ubl conjugation pathway	Active site (2); Alternative sequence (2); Beta strand (17); Chain (1); Domain (2); Frameshift (1); Helix (13); Modified residue (3); Turn (3)
SYVC_HUMAN	P26640	SYVC_HUMAN	reviewed	Valine--tRNA ligase (EC 6.1.1.9) (Protein G7a) (Valyl-tRNA synthetase) (ValRS)	VARS G7A VARS2	Homo sapiens (Human)	1264	cytosol [GO:0005829]; mitochondrion [GO:0005739]; aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; valine-tRNA ligase activity [GO:0004832]; gene expression [GO:0010467]; tRNA aminoacylation for protein translation [GO:0006418]; valyl-tRNA aminoacylation [GO:0006438]	gene expression [GO:0010467]; tRNA aminoacylation for protein translation [GO:0006418]; valyl-tRNA aminoacylation [GO:0006438]	aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; valine-tRNA ligase activity [GO:0004832]	cytosol [GO:0005829]; mitochondrion [GO:0005739]	GO:0005524; GO:0002161; GO:0005829; GO:0010467; GO:0005739; GO:0006418; GO:0004832; GO:0006438		ATP-binding; Acetylation; Alternative splicing; Aminoacyl-tRNA synthetase; Complete proteome; Direct protein sequencing; Ligase; Nucleotide-binding; Polymorphism; Protein biosynthesis; Reference proteome	Alternative sequence (3); Binding site (1); Chain (1); Domain (1); Frameshift (1); Initiator methionine (1); Modified residue (2); Motif (2); Natural variant (5); Sequence conflict (7)
A8MUM1_HUMAN	A8MUM1	A8MUM1_HUMAN	unreviewed	Protein TSSC1	TSSC1	Homo sapiens (Human)	414							Complete proteome; Proteomics identification; Reference proteome; Repeat; WD repeat	
RL14_HUMAN	P50914	RL14_HUMAN	reviewed	60S ribosomal protein L14 (CAG-ISL 7)	RPL14	Homo sapiens (Human)	215	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; membrane [GO:0016020]	GO:0003723; GO:0006614; GO:0044267; GO:0005737; GO:0005829; GO:0022625; GO:0070062; GO:0010467; GO:0016020; GO:0000184; GO:0044822; GO:0006364; GO:0042273; GO:0003735; GO:0006412; GO:0006414; GO:0006413; GO:0006415; GO:0019058; GO:0016032; GO:0019083		3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Ribonucleoprotein; Ribosomal protein; Triplet repeat expansion	Chain (1); Initiator methionine (1); Modified residue (5); Natural variant (8); Region (2); Repeat (6); Sequence conflict (1)
A8MX94_HUMAN	A8MX94	A8MX94_HUMAN	unreviewed	Glutathione S-transferase P	GSTP1	Homo sapiens (Human)	174	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; glutathione transferase activity [GO:0004364]		glutathione transferase activity [GO:0004364]	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0005737; GO:0004364; GO:0005886		Complete proteome; Proteomics identification; Reference proteome	
MYG1_HUMAN	Q9HB07	MYG1_HUMAN	reviewed	UPF0160 protein MYG1, mitochondrial	C12orf10	Homo sapiens (Human)	376	extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; locomotory exploration behavior [GO:0035641]; pigmentation [GO:0043473]	locomotory exploration behavior [GO:0035641]; pigmentation [GO:0043473]		extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0070062; GO:0035641; GO:0005739; GO:0005654; GO:0005634; GO:0043473	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19014353}. Mitochondrion {ECO:0000269|PubMed:19014353}.	Acetylation; Complete proteome; Mitochondrion; Nucleus; Polymorphism; Reference proteome; Transit peptide	Chain (1); Modified residue (2); Natural variant (1); Sequence conflict (3); Transit peptide (1)
MT21A_HUMAN	Q8WXB1	MT21A_HUMAN	reviewed	Protein N-lysine methyltransferase METTL21A (EC 2.1.1.-) (HSPA lysine methyltransferase) (HSPA-KMT) (Hepatocellular carcinoma-associated antigen 557b) (Methyltransferase-like protein 21A)	METTL21A FAM119A HCA557B	Homo sapiens (Human)	218	cytoplasm [GO:0005737]; ATPase binding [GO:0051117]; Hsp70 protein binding [GO:0030544]; protein-lysine N-methyltransferase activity [GO:0016279]; peptidyl-lysine methylation [GO:0018022]; protein methylation [GO:0006479]	peptidyl-lysine methylation [GO:0018022]; protein methylation [GO:0006479]	ATPase binding [GO:0051117]; Hsp70 protein binding [GO:0030544]; protein-lysine N-methyltransferase activity [GO:0016279]	cytoplasm [GO:0005737]	GO:0051117; GO:0030544; GO:0005737; GO:0018022; GO:0006479; GO:0016279	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23349634}.	3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Methyltransferase; Polymorphism; Reference proteome; S-adenosyl-L-methionine; Transferase	Alternative sequence (2); Beta strand (9); Binding site (4); Chain (1); Helix (10); Mutagenesis (1); Natural variant (1); Region (1); Sequence conflict (1); Turn (2)
SF3B3_HUMAN	Q15393	SF3B3_HUMAN	reviewed	Splicing factor 3B subunit 3 (Pre-mRNA-splicing factor SF3b 130 kDa subunit) (SF3b130) (STAF130) (Spliceosome-associated protein 130) (SAP 130)	SF3B3 KIAA0017 SAP130	Homo sapiens (Human)	1217	catalytic step 2 spliceosome [GO:0071013]; nucleoplasm [GO:0005654]; small nuclear ribonucleoprotein complex [GO:0030532]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]; RNA binding [GO:0003723]; gene expression [GO:0010467]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of protein catabolic process [GO:0042177]; protein complex assembly [GO:0006461]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]	gene expression [GO:0010467]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of protein catabolic process [GO:0042177]; protein complex assembly [GO:0006461]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]	RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; nucleoplasm [GO:0005654]; small nuclear ribonucleoprotein complex [GO:0030532]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]	GO:0003723; GO:0008380; GO:0000375; GO:0005689; GO:0071013; GO:0010467; GO:0006397; GO:0000398; GO:0042177; GO:0005654; GO:0006461; GO:0030532; GO:0005681	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11564863}.	Alternative splicing; Complete proteome; Nucleus; Polymorphism; Reference proteome; Spliceosome; mRNA processing; mRNA splicing	Alternative sequence (3); Chain (1); Erroneous initiation (2); Natural variant (1); Sequence conflict (5)
SMN_HUMAN	Q16637	SMN_HUMAN	reviewed	Survival motor neuron protein (Component of gems 1) (Gemin-1)	SMN1 SMN SMNT; SMN2 SMNC	Homo sapiens (Human)	294	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Gemini of coiled bodies [GO:0097504]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SMN complex [GO:0032797]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681]; Z disc [GO:0030018]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; gene expression [GO:0010467]; ncRNA metabolic process [GO:0034660]; nervous system development [GO:0007399]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]	gene expression [GO:0010467]; ncRNA metabolic process [GO:0034660]; nervous system development [GO:0007399]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]	identical protein binding [GO:0042802]; RNA binding [GO:0003723]	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Gemini of coiled bodies [GO:0097504]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SMN complex [GO:0032797]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681]; Z disc [GO:0030018]	GO:0015030; GO:0097504; GO:0003723; GO:0032797; GO:0034719; GO:0030018; GO:0005737; GO:0005829; GO:0010467; GO:0042802; GO:0034660; GO:0007399; GO:0005654; GO:0005634; GO:0005681; GO:0000245; GO:0000387	SUBCELLULAR LOCATION: Cytoplasm. Nucleus, gem. Nucleus, Cajal body. Cytoplasmic granule. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Colocalizes with Actn at the Z-line of skeletal muscle (By similarity). Under stress conditions colocalizes with RPP20/POP7 in punctuated cytoplasmic granules. Colocalized and redistributed with ZPR1 from the cytoplasm to nuclear gems (Gemini of coiled bodies) and Cajal bodies. {ECO:0000250}.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Disease mutation; Neurodegeneration; Neurogenesis; Nucleus; Phosphoprotein; RNA-binding; Reference proteome; mRNA processing; mRNA splicing	Alternative sequence (3); Beta strand (10); Chain (1); Compositional bias (3); Domain (1); Helix (3); Initiator methionine (1); Modified residue (9); Mutagenesis (1); Natural variant (15); Region (4); Turn (6)
M4K4_HUMAN	O95819	M4K4_HUMAN	reviewed	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)	MAP4K4 HGK KIAA0687 NIK	Homo sapiens (Human)	1239	cytoplasm [GO:0005737]; ATP binding [GO:0005524]; creatine kinase activity [GO:0004111]; protein serine/threonine kinase activity [GO:0004674]; intracellular signal transduction [GO:0035556]; negative regulation of apoptotic process [GO:0043066]; protein phosphorylation [GO:0006468]; regulation of JNK cascade [GO:0046328]	intracellular signal transduction [GO:0035556]; negative regulation of apoptotic process [GO:0043066]; protein phosphorylation [GO:0006468]; regulation of JNK cascade [GO:0046328]	ATP binding [GO:0005524]; creatine kinase activity [GO:0004111]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]	GO:0005524; GO:0004111; GO:0005737; GO:0035556; GO:0043066; GO:0006468; GO:0004674; GO:0046328	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14966141}.	3D-structure; ATP-binding; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase	Active site (1); Alternative sequence (5); Beta strand (9); Binding site (1); Chain (1); Domain (2); Helix (16); Initiator methionine (1); Modified residue (11); Natural variant (2); Nucleotide binding (1); Region (1); Sequence conflict (3); Turn (5)
G5E948_HUMAN	G5E948	G5E948_HUMAN	unreviewed	Mitogen-activated protein kinase kinase kinase kinase 4	MAP4K4	Homo sapiens (Human)	1235	intracellular [GO:0005622]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; activation of protein kinase activity [GO:0032147]; MAPK cascade [GO:0000165]; neuron projection morphogenesis [GO:0048812]; regulation of mitotic cell cycle [GO:0007346]; stress-activated protein kinase signaling cascade [GO:0031098]	activation of protein kinase activity [GO:0032147]; MAPK cascade [GO:0000165]; neuron projection morphogenesis [GO:0048812]; regulation of mitotic cell cycle [GO:0007346]; stress-activated protein kinase signaling cascade [GO:0031098]	ATP binding [GO:0005524]; protein kinase activity [GO:0004672]	intracellular [GO:0005622]	GO:0005524; GO:0000165; GO:0032147; GO:0005622; GO:0048812; GO:0004672; GO:0007346; GO:0031098		ATP-binding; Complete proteome; Nucleotide-binding; Proteomics identification; Reference proteome	
PCIF1_HUMAN	Q9H4Z3	PCIF1_HUMAN	reviewed	Phosphorylated CTD-interacting factor 1	PCIF1 C20orf67	Homo sapiens (Human)	704	intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; negative regulation of phosphatase activity [GO:0010923]	negative regulation of phosphatase activity [GO:0010923]		intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]	GO:0045171; GO:0015630; GO:0010923; GO:0005654	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12565871}.	3D-structure; Complete proteome; Nucleus; Phosphoprotein; Reference proteome	Beta strand (3); Chain (1); Compositional bias (1); Domain (1); Helix (1); Modified residue (3); Motif (2); Turn (2)
SYLC_HUMAN	Q9P2J5	SYLC_HUMAN	reviewed	Leucine--tRNA ligase, cytoplasmic (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS)	LARS KIAA1352	Homo sapiens (Human)	1176	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; leucine-tRNA ligase activity [GO:0004823]; gene expression [GO:0010467]; leucyl-tRNA aminoacylation [GO:0006429]; tRNA aminoacylation for protein translation [GO:0006418]	gene expression [GO:0010467]; leucyl-tRNA aminoacylation [GO:0006429]; tRNA aminoacylation for protein translation [GO:0006418]	aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; leucine-tRNA ligase activity [GO:0004823]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0005524; GO:0002161; GO:0005737; GO:0005829; GO:0010467; GO:0004823; GO:0006429; GO:0005634; GO:0006418	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.	3D-structure; ATP-binding; Acetylation; Alternative splicing; Aminoacyl-tRNA synthetase; Complete proteome; Cytoplasm; Disease mutation; Ligase; Nucleotide-binding; Polymorphism; Protein biosynthesis; Reference proteome	Alternative sequence (2); Beta strand (16); Binding site (1); Chain (1); Erroneous initiation (1); Helix (10); Modified residue (2); Motif (2); Natural variant (3); Region (1); Sequence conflict (3); Turn (5)
AIMP1_HUMAN	Q12904	AIMP1_HUMAN	reviewed	Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (Multisynthase complex auxiliary component p43) [Cleaved into: Endothelial monocyte-activating polypeptide 2 (EMAP-2) (Endothelial monocyte-activating polypeptide II) (EMAP-II) (Small inducible cytokine subfamily E member 1)]	AIMP1 EMAP2 SCYE1	Homo sapiens (Human)	312	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleus [GO:0005634]; transport vesicle [GO:0030133]; cytokine activity [GO:0005125]; GTPase binding [GO:0051020]; protein homodimerization activity [GO:0042803]; tRNA binding [GO:0000049]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; chemotaxis [GO:0006935]; gene expression [GO:0010467]; glucose metabolic process [GO:0006006]; inflammatory response [GO:0006954]; leukocyte migration [GO:0050900]; negative regulation of endothelial cell proliferation [GO:0001937]; response to wounding [GO:0009611]; signal transduction [GO:0007165]; tRNA aminoacylation for protein translation [GO:0006418]	angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; chemotaxis [GO:0006935]; gene expression [GO:0010467]; glucose metabolic process [GO:0006006]; inflammatory response [GO:0006954]; leukocyte migration [GO:0050900]; negative regulation of endothelial cell proliferation [GO:0001937]; response to wounding [GO:0009611]; signal transduction [GO:0007165]; tRNA aminoacylation for protein translation [GO:0006418]	cytokine activity [GO:0005125]; GTPase binding [GO:0051020]; protein homodimerization activity [GO:0042803]; tRNA binding [GO:0000049]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleus [GO:0005634]; transport vesicle [GO:0030133]	GO:0051020; GO:0005794; GO:0017101; GO:0001525; GO:0006915; GO:0007155; GO:0009986; GO:0007267; GO:0006935; GO:0005125; GO:0005737; GO:0005829; GO:0005783; GO:0005615; GO:0010467; GO:0006006; GO:0006954; GO:0050900; GO:0016020; GO:0001937; GO:0005634; GO:0042803; GO:0009611; GO:0007165; GO:0006418; GO:0000049; GO:0030133	SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle, secretory vesicle {ECO:0000250}. Secreted {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Enriched in secretory vesicles of pancreatic alpha cells and secreted from the pancreas in response to low glucose levels (By similarity). Also secreted in response to hypoxia and both apoptotic and necrotic cell death. {ECO:0000250}.	3D-structure; Acetylation; Alternative splicing; Angiogenesis; Apoptosis; Carbohydrate metabolism; Cell adhesion; Complete proteome; Cytokine; Cytoplasm; Cytoplasmic vesicle; Endoplasmic reticulum; Glucose metabolism; Golgi apparatus; Inflammatory response; Leukodystrophy; Nucleus; Polymorphism; Protein biosynthesis; RNA-binding; Reference proteome; Secreted; tRNA-binding	Alternative sequence (1); Beta strand (13); Chain (2); Domain (1); Helix (4); Initiator methionine (1); Modified residue (2); Natural variant (3); Region (4); Sequence conflict (1); Turn (3)
TF2AA_HUMAN	P52655	TF2AA_HUMAN	reviewed	Transcription initiation factor IIA subunit 1 (General transcription factor IIA subunit 1) (TFIIAL) (Transcription initiation factor TFIIA 42 kDa subunit) (TFIIA-42) [Cleaved into: Transcription initiation factor IIA alpha chain (TFIIA p35 subunit); Transcription initiation factor IIA beta chain (TFIIA p19 subunit)]	GTF2A1 TF2A1	Homo sapiens (Human)	376	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; transcription factor TFIIA complex [GO:0005672]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; TBP-class protein binding [GO:0017025]; transcription coactivator activity [GO:0003713]; transcription factor binding [GO:0008134]; gene expression [GO:0010467]; regulation of transcription, DNA-templated [GO:0006355]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]; viral process [GO:0016032]	gene expression [GO:0010467]; regulation of transcription, DNA-templated [GO:0006355]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]; viral process [GO:0016032]	DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; TBP-class protein binding [GO:0017025]; transcription coactivator activity [GO:0003713]; transcription factor binding [GO:0008134]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; transcription factor TFIIA complex [GO:0005672]	GO:0003677; GO:0017025; GO:0005737; GO:0010467; GO:0005654; GO:0046982; GO:0006355; GO:0003713; GO:0006368; GO:0005672; GO:0008134; GO:0006366; GO:0006367; GO:0016032	SUBCELLULAR LOCATION: Nucleus.	3D-structure; Acetylation; Alternative initiation; Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation	Alternative sequence (1); Beta strand (3); Chain (3); Compositional bias (2); Helix (2); Initiator methionine (1); Modified residue (5); Mutagenesis (13); Natural variant (2); Site (1)
GGCT_HUMAN	O75223	GGCT_HUMAN	reviewed	Gamma-glutamylcyclotransferase (EC 2.3.2.4) (Cytochrome c-releasing factor 21)	GGCT C7orf24 CRF21	Homo sapiens (Human)	188	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; gamma-glutamylcyclotransferase activity [GO:0003839]; protein homodimerization activity [GO:0042803]; glutathione biosynthetic process [GO:0006750]; glutathione derivative biosynthetic process [GO:1901687]; release of cytochrome c from mitochondria [GO:0001836]; small molecule metabolic process [GO:0044281]; xenobiotic metabolic process [GO:0006805]	glutathione biosynthetic process [GO:0006750]; glutathione derivative biosynthetic process [GO:1901687]; release of cytochrome c from mitochondria [GO:0001836]; small molecule metabolic process [GO:0044281]; xenobiotic metabolic process [GO:0006805]	gamma-glutamylcyclotransferase activity [GO:0003839]; protein homodimerization activity [GO:0042803]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0005829; GO:0070062; GO:0003839; GO:0006750; GO:1901687; GO:0042803; GO:0001836; GO:0044281; GO:0006805		3D-structure; Acyltransferase; Alternative splicing; Complete proteome; Phosphoprotein; Reference proteome; Transferase	Active site (1); Alternative sequence (4); Beta strand (6); Binding site (1); Chain (1); Helix (8); Modified residue (1); Mutagenesis (4); Region (1); Turn (1)
PSA4_HUMAN	P25789	PSA4_HUMAN	reviewed	Proteasome subunit alpha type-4 (EC 3.4.25.1) (Macropain subunit C9) (Multicatalytic endopeptidase complex subunit C9) (Proteasome component C9) (Proteasome subunit L)	PSMA4 HC9 PSC9	Homo sapiens (Human)	261	cytoplasm [GO:0005737]; cytoplasmic mRNA processing body [GO:0000932]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]; endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298]; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298]	cytoplasm [GO:0005737]; cytoplasmic mRNA processing body [GO:0000932]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]	GO:0006977; GO:0000082; GO:0031145; GO:0042590; GO:0002479; GO:0002474; GO:0006915; GO:0034641; GO:0005737; GO:0000932; GO:0005829; GO:0004175; GO:0070062; GO:0010467; GO:0045087; GO:0043231; GO:0000278; GO:0043066; GO:0090090; GO:0051436; GO:0005654; GO:0005634; GO:0005886; GO:0090263; GO:0051437; GO:0012501; GO:0010499; GO:0000502; GO:0005839; GO:0019773; GO:0043161; GO:0000209; GO:0042981; GO:0006521; GO:0051439; GO:0044281; GO:0002223; GO:0004298; GO:0016032	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, P-body {ECO:0000250}. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250}.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Host-virus interaction; Hydrolase; Nucleus; Phosphoprotein; Protease; Proteasome; Reference proteome; Threonine protease	Alternative sequence (1); Beta strand (11); Chain (1); Helix (6); Modified residue (5); Turn (6)
PDIA1_HUMAN	P07237	PDIA1_HUMAN	reviewed	Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55)	P4HB ERBA2L PDI PDIA1 PO4DB	Homo sapiens (Human)	508	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; melanosome [GO:0042470]; plasma membrane [GO:0005886]; procollagen-proline 4-dioxygenase complex [GO:0016222]; endopeptidase activity [GO:0004175]; poly(A) RNA binding [GO:0044822]; procollagen-proline 4-dioxygenase activity [GO:0004656]; protein disulfide isomerase activity [GO:0003756]; cell redox homeostasis [GO:0045454]; cellular response to hypoxia [GO:0071456]; extracellular matrix organization [GO:0030198]; lipoprotein metabolic process [GO:0042157]; peptidyl-proline hydroxylation to 4-hydroxy-L-proline [GO:0018401]; protein folding [GO:0006457]; proteolysis [GO:0006508]; regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902175]; response to endoplasmic reticulum stress [GO:0034976]; response to reactive oxygen species [GO:0000302]; small molecule metabolic process [GO:0044281]	cell redox homeostasis [GO:0045454]; cellular response to hypoxia [GO:0071456]; extracellular matrix organization [GO:0030198]; lipoprotein metabolic process [GO:0042157]; peptidyl-proline hydroxylation to 4-hydroxy-L-proline [GO:0018401]; protein folding [GO:0006457]; proteolysis [GO:0006508]; regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902175]; response to endoplasmic reticulum stress [GO:0034976]; response to reactive oxygen species [GO:0000302]; small molecule metabolic process [GO:0044281]	endopeptidase activity [GO:0004175]; poly(A) RNA binding [GO:0044822]; procollagen-proline 4-dioxygenase activity [GO:0004656]; protein disulfide isomerase activity [GO:0003756]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; melanosome [GO:0042470]; plasma membrane [GO:0005886]; procollagen-proline 4-dioxygenase complex [GO:0016222]	GO:0045454; GO:0071456; GO:0004175; GO:0005783; GO:0005788; GO:0005793; GO:0070062; GO:0030198; GO:0005576; GO:0005925; GO:0042157; GO:0042470; GO:0018401; GO:0005886; GO:0044822; GO:0004656; GO:0016222; GO:0003756; GO:0006457; GO:0006508; GO:1902175; GO:0034976; GO:0000302; GO:0044281	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen. Melanosome. Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Highly abundant. In some cell types, seems to be also secreted or associated with the plasma membrane, where it undergoes constant shedding and replacement from intracellular sources (Probable). Localizes near CD4-enriched regions on lymphoid cell surfaces. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000305}.	3D-structure; Acetylation; Cell membrane; Chaperone; Complete proteome; Direct protein sequencing; Disulfide bond; Endoplasmic reticulum; Isomerase; Membrane; Redox-active center; Reference proteome; Repeat; Signal	Active site (4); Beta strand (28); Chain (1); Disulfide bond (2); Domain (2); Helix (18); Modified residue (3); Motif (1); Sequence conflict (12); Signal peptide (1); Site (6); Turn (9)
PPP6_HUMAN	O00743	PPP6_HUMAN	reviewed	Serine/threonine-protein phosphatase 6 catalytic subunit (PP6C) (EC 3.1.3.16) [Cleaved into: Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed]	PPP6C PPP6	Homo sapiens (Human)	305	cytosol [GO:0005829]; metal ion binding [GO:0046872]; protein serine/threonine phosphatase activity [GO:0004722]; G1/S transition of mitotic cell cycle [GO:0000082]; protein dephosphorylation [GO:0006470]	G1/S transition of mitotic cell cycle [GO:0000082]; protein dephosphorylation [GO:0006470]	metal ion binding [GO:0046872]; protein serine/threonine phosphatase activity [GO:0004722]	cytosol [GO:0005829]	GO:0000082; GO:0005829; GO:0046872; GO:0006470; GO:0004722	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16769727, ECO:0000269|PubMed:17568194}.	Acetylation; Alternative splicing; Cell cycle; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Manganese; Metal-binding; Protein phosphatase; Reference proteome	Active site (1); Alternative sequence (2); Chain (2); Initiator methionine (1); Metal binding (7); Modified residue (1); Sequence conflict (1)
COPE_HUMAN	O14579	COPE_HUMAN	reviewed	Coatomer subunit epsilon (Epsilon-coat protein) (Epsilon-COP)	COPE	Homo sapiens (Human)	308	COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; structural molecule activity [GO:0005198]; COPI coating of Golgi vesicle [GO:0048205]; ER to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; membrane organization [GO:0061024]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]	COPI coating of Golgi vesicle [GO:0048205]; ER to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; membrane organization [GO:0061024]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]	structural molecule activity [GO:0005198]	COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]	GO:0048205; GO:0030126; GO:0006888; GO:0005794; GO:0005829; GO:0006891; GO:0061024; GO:0005654; GO:0015031; GO:0006890; GO:0005198	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}.	Alternative splicing; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Direct protein sequencing; ER-Golgi transport; Golgi apparatus; Membrane; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport; Ubl conjugation	Alternative sequence (3); Chain (1); Initiator methionine (1); Modified residue (1); Natural variant (2)
M0QXB4_HUMAN	M0QXB4	M0QXB4_HUMAN	unreviewed	Coatomer protein complex, subunit epsilon, isoform CRA_g (Coatomer subunit epsilon)	COPE hCG_2001439	Homo sapiens (Human)	331	COPI vesicle coat [GO:0030126]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; structural molecule activity [GO:0005198]; ER to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]	ER to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]	structural molecule activity [GO:0005198]	COPI vesicle coat [GO:0030126]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]	GO:0030126; GO:0006888; GO:0005794; GO:0006891; GO:0005654; GO:0006890; GO:0005198		Complete proteome; Proteomics identification; Reference proteome	
AATC_HUMAN	P17174	AATC_HUMAN	reviewed	Aspartate aminotransferase, cytoplasmic (cAspAT) (EC 2.6.1.1) (EC 2.6.1.3) (Cysteine aminotransferase, cytoplasmic) (Cysteine transaminase, cytoplasmic) (cCAT) (Glutamate oxaloacetate transaminase 1) (Transaminase A)	GOT1	Homo sapiens (Human)	413	axon terminus [GO:0043679]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lysosome [GO:0005764]; nucleus [GO:0005634]; carboxylic acid binding [GO:0031406]; L-aspartate:2-oxoglutarate aminotransferase activity [GO:0004069]; L-cysteine:2-oxoglutarate aminotransferase activity [GO:0047801]; L-phenylalanine:2-oxoglutarate aminotransferase activity [GO:0080130]; phosphatidylserine decarboxylase activity [GO:0004609]; pyridoxal phosphate binding [GO:0030170]; 2-oxoglutarate metabolic process [GO:0006103]; aspartate biosynthetic process [GO:0006532]; aspartate catabolic process [GO:0006533]; aspartate metabolic process [GO:0006531]; carbohydrate metabolic process [GO:0005975]; cellular amino acid biosynthetic process [GO:0008652]; cellular nitrogen compound metabolic process [GO:0034641]; cellular response to insulin stimulus [GO:0032869]; fatty acid homeostasis [GO:0055089]; gluconeogenesis [GO:0006094]; glucose metabolic process [GO:0006006]; glutamate catabolic process to 2-oxoglutarate [GO:0019551]; glutamate catabolic process to aspartate [GO:0019550]; glutamate metabolic process [GO:0006536]; glycerol biosynthetic process [GO:0006114]; L-methionine biosynthetic process from methylthioadenosine [GO:0019509]; oxaloacetate metabolic process [GO:0006107]; polyamine metabolic process [GO:0006595]; response to glucocorticoid [GO:0051384]; small molecule metabolic process [GO:0044281]; sulfur amino acid metabolic process [GO:0000096]	2-oxoglutarate metabolic process [GO:0006103]; aspartate biosynthetic process [GO:0006532]; aspartate catabolic process [GO:0006533]; aspartate metabolic process [GO:0006531]; carbohydrate metabolic process [GO:0005975]; cellular amino acid biosynthetic process [GO:0008652]; cellular nitrogen compound metabolic process [GO:0034641]; cellular response to insulin stimulus [GO:0032869]; fatty acid homeostasis [GO:0055089]; gluconeogenesis [GO:0006094]; glucose metabolic process [GO:0006006]; glutamate catabolic process to 2-oxoglutarate [GO:0019551]; glutamate catabolic process to aspartate [GO:0019550]; glutamate metabolic process [GO:0006536]; glycerol biosynthetic process [GO:0006114]; L-methionine biosynthetic process from methylthioadenosine [GO:0019509]; oxaloacetate metabolic process [GO:0006107]; polyamine metabolic process [GO:0006595]; response to glucocorticoid [GO:0051384]; small molecule metabolic process [GO:0044281]; sulfur amino acid metabolic process [GO:0000096]	carboxylic acid binding [GO:0031406]; L-aspartate:2-oxoglutarate aminotransferase activity [GO:0004069]; L-cysteine:2-oxoglutarate aminotransferase activity [GO:0047801]; L-phenylalanine:2-oxoglutarate aminotransferase activity [GO:0080130]; phosphatidylserine decarboxylase activity [GO:0004609]; pyridoxal phosphate binding [GO:0030170]	axon terminus [GO:0043679]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lysosome [GO:0005764]; nucleus [GO:0005634]	GO:0006103; GO:0004069; GO:0047801; GO:0019509; GO:0080130; GO:0006532; GO:0006533; GO:0006531; GO:0043679; GO:0005975; GO:0031406; GO:0008652; GO:0034641; GO:0032869; GO:0005737; GO:0005829; GO:0070062; GO:0055089; GO:0006094; GO:0006006; GO:0019551; GO:0019550; GO:0006536; GO:0006114; GO:0005764; GO:0005634; GO:0006107; GO:0004609; GO:0006595; GO:0030170; GO:0051384; GO:0044281; GO:0000096	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:1974457}.	3D-structure; Alternative splicing; Amino-acid biosynthesis; Aminotransferase; Complete proteome; Cytoplasm; Direct protein sequencing; Polymorphism; Pyridoxal phosphate; Reference proteome; Transferase	Alternative sequence (1); Beta strand (10); Binding site (4); Chain (1); Helix (18); Initiator methionine (1); Modified residue (1); Natural variant (1); Sequence conflict (1); Turn (6)
6PGD_HUMAN	P52209	6PGD_HUMAN	reviewed	6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44)	PGD PGDH	Homo sapiens (Human)	483	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; NADP binding [GO:0050661]; phosphogluconate dehydrogenase (decarboxylating) activity [GO:0004616]; carbohydrate metabolic process [GO:0005975]; D-gluconate metabolic process [GO:0019521]; oxidation-reduction process [GO:0055114]; pentose biosynthetic process [GO:0019322]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, oxidative branch [GO:0009051]; small molecule metabolic process [GO:0044281]	carbohydrate metabolic process [GO:0005975]; D-gluconate metabolic process [GO:0019521]; oxidation-reduction process [GO:0055114]; pentose biosynthetic process [GO:0019322]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, oxidative branch [GO:0009051]; small molecule metabolic process [GO:0044281]	NADP binding [GO:0050661]; phosphogluconate dehydrogenase (decarboxylating) activity [GO:0004616]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	GO:0019521; GO:0050661; GO:0005975; GO:0005829; GO:0070062; GO:0005634; GO:0055114; GO:0019322; GO:0006098; GO:0009051; GO:0004616; GO:0044281	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Gluconate utilization; NADP; Oxidoreductase; Pentose shunt; Polymorphism; Reference proteome	Active site (2); Alternative sequence (1); Beta strand (10); Binding site (7); Chain (1); Helix (23); Initiator methionine (1); Modified residue (3); Natural variant (1); Nucleotide binding (4); Region (2); Sequence conflict (2); Turn (3)
BAG2_HUMAN	O95816	BAG2_HUMAN	reviewed	BAG family molecular chaperone regulator 2 (BAG-2) (Bcl-2-associated athanogene 2)	BAG2	Homo sapiens (Human)	211	cytosol [GO:0005829]; identical protein binding [GO:0042802]; cellular response to heat [GO:0034605]; protein folding [GO:0006457]; protein metabolic process [GO:0019538]; regulation of cellular response to heat [GO:1900034]	cellular response to heat [GO:0034605]; protein folding [GO:0006457]; protein metabolic process [GO:0019538]; regulation of cellular response to heat [GO:1900034]	identical protein binding [GO:0042802]	cytosol [GO:0005829]	GO:0034605; GO:0005829; GO:0042802; GO:0006457; GO:0019538; GO:1900034		Acetylation; Alternative splicing; Chaperone; Coiled coil; Complete proteome; Phosphoprotein; Reference proteome	Alternative sequence (1); Chain (1); Coiled coil (1); Domain (1); Initiator methionine (1); Modified residue (3); Sequence conflict (1)
GRAP1_HUMAN	Q4V328	GRAP1_HUMAN	reviewed	GRIP1-associated protein 1 (GRASP-1)	GRIPAP1 KIAA1167	Homo sapiens (Human)	841	blood microparticle [GO:0072562]; early endosome [GO:0005769]			blood microparticle [GO:0072562]; early endosome [GO:0005769]	GO:0072562; GO:0005769	SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:15897011}.	Acetylation; Alternative splicing; Coiled coil; Complete proteome; Direct protein sequencing; Endosome; Phosphoprotein; Reference proteome	Alternative sequence (7); Chain (1); Coiled coil (4); Initiator methionine (1); Modified residue (6); Sequence conflict (1); Site (1)
CARF_HUMAN	Q9NXV6	CARF_HUMAN	reviewed	CDKN2A-interacting protein (Collaborator of ARF)	CDKN2AIP CARF	Homo sapiens (Human)	580	cytoplasm [GO:0005737]; granular component [GO:0001652]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; p53 binding [GO:0002039]; RNA binding [GO:0003723]; cellular response to DNA damage stimulus [GO:0006974]; negative regulation of cell growth [GO:0030308]; positive regulation of cell growth [GO:0030307]; positive regulation of signal transduction [GO:0009967]; regulation of protein stability [GO:0031647]	cellular response to DNA damage stimulus [GO:0006974]; negative regulation of cell growth [GO:0030308]; positive regulation of cell growth [GO:0030307]; positive regulation of signal transduction [GO:0009967]; regulation of protein stability [GO:0031647]	p53 binding [GO:0002039]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; granular component [GO:0001652]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003723; GO:0006974; GO:0005737; GO:0001652; GO:0030308; GO:0005730; GO:0005654; GO:0005634; GO:0002039; GO:0030307; GO:0009967; GO:0031647	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:12154087, ECO:0000269|PubMed:12581788}.	Acetylation; Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein; RNA-binding; Reference proteome; Ubl conjugation	Chain (1); Compositional bias (1); Domain (1); Frameshift (1); Initiator methionine (1); Modified residue (3); Sequence conflict (2)
PLPP_HUMAN	Q96GD0	PLPP_HUMAN	reviewed	Pyridoxal phosphate phosphatase (PLP phosphatase) (EC 3.1.3.3) (EC 3.1.3.74) (Chronophin)	PDXP CIN PLP PLPP	Homo sapiens (Human)	296	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lamellipodium membrane [GO:0031258]; ruffle membrane [GO:0032587]; heat shock protein binding [GO:0031072]; magnesium ion binding [GO:0000287]; phosphoprotein phosphatase activity [GO:0004721]; phosphoserine phosphatase activity [GO:0004647]; pyridoxal phosphatase activity [GO:0033883]; actin rod assembly [GO:0031247]; cellular response to ATP [GO:0071318]; positive regulation of actin filament depolymerization [GO:0030836]; protein dephosphorylation [GO:0006470]; pyridoxal phosphate catabolic process [GO:0032361]; regulation of cytokinesis [GO:0032465]; regulation of mitotic nuclear division [GO:0007088]	actin rod assembly [GO:0031247]; cellular response to ATP [GO:0071318]; positive regulation of actin filament depolymerization [GO:0030836]; protein dephosphorylation [GO:0006470]; pyridoxal phosphate catabolic process [GO:0032361]; regulation of cytokinesis [GO:0032465]; regulation of mitotic nuclear division [GO:0007088]	heat shock protein binding [GO:0031072]; magnesium ion binding [GO:0000287]; phosphoprotein phosphatase activity [GO:0004721]; phosphoserine phosphatase activity [GO:0004647]; pyridoxal phosphatase activity [GO:0033883]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lamellipodium membrane [GO:0031258]; ruffle membrane [GO:0032587]	GO:0031247; GO:0071318; GO:0005856; GO:0005829; GO:0070062; GO:0031072; GO:0031258; GO:0000287; GO:0004721; GO:0004647; GO:0030836; GO:0006470; GO:0033883; GO:0032361; GO:0032465; GO:0007088; GO:0032587	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:15580268}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15580268}. Cell projection, ruffle membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Cell membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Diffusely distributed throughout the cytosol during pro-metaphase and metaphase. Detected at the dynamic cell poles during telophase. Detected at the cleavage furrow and contractile ring during cytokinesis. Transiently detected at the plasma membrane in late stages of cytokinesis. Detected at the midbody.	3D-structure; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Hydrolase; Magnesium; Membrane; Metal-binding; Pyridoxal phosphate; Reference proteome	Active site (2); Beta strand (13); Binding site (2); Chain (1); Helix (14); Metal binding (3); Mutagenesis (1); Region (1); Turn (2)
PEBB_HUMAN	Q13951	PEBB_HUMAN	reviewed	Core-binding factor subunit beta (CBF-beta) (Polyomavirus enhancer-binding protein 2 beta subunit) (PEA2-beta) (PEBP2-beta) (SL3-3 enhancer factor 1 subunit beta) (SL3/AKV core-binding factor beta subunit)	CBFB	Homo sapiens (Human)	182	membrane [GO:0016020]; nucleus [GO:0005634]; DNA binding [GO:0003677]; sequence-specific DNA binding transcription factor activity [GO:0003700]; transcription coactivator activity [GO:0003713]; cell maturation [GO:0048469]; definitive hemopoiesis [GO:0060216]; lymphocyte differentiation [GO:0030098]; myeloid cell differentiation [GO:0030099]; osteoblast differentiation [GO:0001649]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein polyubiquitination [GO:0000209]; transcription from RNA polymerase II promoter [GO:0006366]	cell maturation [GO:0048469]; definitive hemopoiesis [GO:0060216]; lymphocyte differentiation [GO:0030098]; myeloid cell differentiation [GO:0030099]; osteoblast differentiation [GO:0001649]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein polyubiquitination [GO:0000209]; transcription from RNA polymerase II promoter [GO:0006366]	DNA binding [GO:0003677]; sequence-specific DNA binding transcription factor activity [GO:0003700]; transcription coactivator activity [GO:0003713]	membrane [GO:0016020]; nucleus [GO:0005634]	GO:0003677; GO:0048469; GO:0060216; GO:0030098; GO:0016020; GO:0030099; GO:0005634; GO:0001649; GO:0045944; GO:0000209; GO:0003700; GO:0003713; GO:0006366	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.	3D-structure; Alternative splicing; Chromosomal rearrangement; Complete proteome; Nucleus; Phosphoprotein; Polymorphism; Proto-oncogene; Reference proteome	Alternative sequence (1); Beta strand (8); Chain (1); Helix (6); Natural variant (1); Site (1); Turn (3)
UB2R2_HUMAN	Q712K3	UB2R2_HUMAN	reviewed	Ubiquitin-conjugating enzyme E2 R2 (EC 6.3.2.19) (Ubiquitin carrier protein R2) (Ubiquitin-conjugating enzyme E2-CDC34B) (Ubiquitin-protein ligase R2)	UBE2R2 CDC34B UBC3B	Homo sapiens (Human)	238	cytoplasm [GO:0005737]; ATP binding [GO:0005524]; ligase activity [GO:0016874]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein monoubiquitination [GO:0006513]	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein monoubiquitination [GO:0006513]	ATP binding [GO:0005524]; ligase activity [GO:0016874]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]	GO:0005524; GO:0005737; GO:0016874; GO:0043161; GO:0070936; GO:0006513; GO:0061631; GO:0061630; GO:0031625; GO:0004842		ATP-binding; Complete proteome; Ligase; Nucleotide-binding; Phosphoprotein; Reference proteome; Ubl conjugation pathway	Active site (1); Chain (1); Compositional bias (1); Modified residue (1); Mutagenesis (3); Sequence conflict (2)
STAT3_HUMAN	P40763	STAT3_HUMAN	reviewed	Signal transducer and activator of transcription 3 (Acute-phase response factor)	STAT3 APRF	Homo sapiens (Human)	770	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; nuclear chromatin [GO:0000790]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; RNA polymerase II transcription factor complex [GO:0090575]; DNA binding [GO:0003677]; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [GO:0004879]; protein dimerization activity [GO:0046983]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978]; RNA polymerase II repressing transcription factor binding [GO:0001103]; RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [GO:0001228]; sequence-specific DNA binding transcription factor activity [GO:0003700]; signal transducer activity [GO:0004871]; transcription factor binding [GO:0008134]; transcription regulatory region DNA binding [GO:0044212]; acute-phase response [GO:0006953]; astrocyte differentiation [GO:0048708]; cell proliferation [GO:0008283]; cellular response to hormone stimulus [GO:0032870]; cytokine-mediated signaling pathway [GO:0019221]; eating behavior [GO:0042755]; eye photoreceptor cell differentiation [GO:0001754]; glucose homeostasis [GO:0042593]; growth hormone receptor signaling pathway [GO:0060396]; interleukin-6-mediated signaling pathway [GO:0070102]; intracellular receptor signaling pathway [GO:0030522]; JAK-STAT cascade [GO:0007259]; JAK-STAT cascade involved in growth hormone signaling pathway [GO:0060397]; movement of cell or subcellular component [GO:0006928]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell proliferation [GO:0008285]; negative regulation of glycolytic process [GO:0045820]; negative regulation of neuron migration [GO:2001223]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; nervous system development [GO:0007399]; neurotrophin TRK receptor signaling pathway [GO:0048011]; phosphorylation [GO:0016310]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]; protein import into nucleus [GO:0006606]; radial glial cell differentiation [GO:0060019]; regulation of multicellular organism growth [GO:0040014]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; regulation of transcription, DNA-templated [GO:0006355]; response to drug [GO:0042493]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; sexual reproduction [GO:0019953]; signal transduction [GO:0007165]; somatic stem cell maintenance [GO:0035019]; temperature homeostasis [GO:0001659]; viral process [GO:0016032]	acute-phase response [GO:0006953]; astrocyte differentiation [GO:0048708]; cell proliferation [GO:0008283]; cellular response to hormone stimulus [GO:0032870]; cytokine-mediated signaling pathway [GO:0019221]; eating behavior [GO:0042755]; eye photoreceptor cell differentiation [GO:0001754]; glucose homeostasis [GO:0042593]; growth hormone receptor signaling pathway [GO:0060396]; interleukin-6-mediated signaling pathway [GO:0070102]; intracellular receptor signaling pathway [GO:0030522]; JAK-STAT cascade [GO:0007259]; JAK-STAT cascade involved in growth hormone signaling pathway [GO:0060397]; movement of cell or subcellular component [GO:0006928]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell proliferation [GO:0008285]; negative regulation of glycolytic process [GO:0045820]; negative regulation of neuron migration [GO:2001223]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; nervous system development [GO:0007399]; neurotrophin TRK receptor signaling pathway [GO:0048011]; phosphorylation [GO:0016310]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein import into nucleus [GO:0006606]; radial glial cell differentiation [GO:0060019]; regulation of multicellular organism growth [GO:0040014]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; response to drug [GO:0042493]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; sexual reproduction [GO:0019953]; signal transduction [GO:0007165]; somatic stem cell maintenance [GO:0035019]; temperature homeostasis [GO:0001659]; viral process [GO:0016032]	DNA binding [GO:0003677]; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [GO:0004879]; protein dimerization activity [GO:0046983]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978]; RNA polymerase II repressing transcription factor binding [GO:0001103]; RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [GO:0001228]; sequence-specific DNA binding transcription factor activity [GO:0003700]; signal transducer activity [GO:0004871]; transcription factor binding [GO:0008134]; transcription regulatory region DNA binding [GO:0044212]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; nuclear chromatin [GO:0000790]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; RNA polymerase II transcription factor complex [GO:0090575]	GO:0003677; GO:0007259; GO:0060397; GO:0000978; GO:0001103; GO:0090575; GO:0001228; GO:0006953; GO:0048708; GO:0008283; GO:0032870; GO:0019221; GO:0005737; GO:0005829; GO:0042755; GO:0001754; GO:0042593; GO:0060396; GO:0070102; GO:0030522; GO:0004879; GO:0005743; GO:0006928; GO:0043066; GO:0008285; GO:0045820; GO:2001223; GO:0000122; GO:0007399; GO:0048011; GO:0000790; GO:0005654; GO:0005634; GO:0016310; GO:0005886; GO:0045747; GO:0045944; GO:0045893; GO:0046983; GO:0006606; GO:0019901; GO:0019903; GO:0060019; GO:0040014; GO:0006357; GO:0006355; GO:0042493; GO:0032355; GO:0045471; GO:0003700; GO:0019953; GO:0004871; GO:0007165; GO:0035019; GO:0001659; GO:0008134; GO:0044212; GO:0016032	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1.	Acetylation; Activator; Alternative splicing; Complete proteome; Cytoplasm; DNA-binding; Disease mutation; Dwarfism; Host-virus interaction; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; SH2 domain; Transcription; Transcription regulation	Alternative sequence (3); Chain (1); Domain (1); Initiator methionine (1); Modified residue (4); Motif (1); Natural variant (23); Sequence conflict (7)
DUT_HUMAN	P33316	DUT_HUMAN	reviewed	Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)	DUT	Homo sapiens (Human)	252	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; dUTP diphosphatase activity [GO:0004170]; magnesium ion binding [GO:0000287]; poly(A) RNA binding [GO:0044822]; DNA replication [GO:0006260]; dUMP biosynthetic process [GO:0006226]; dUTP catabolic process [GO:0046081]; nucleobase-containing compound metabolic process [GO:0006139]; nucleobase-containing small molecule metabolic process [GO:0055086]; pyrimidine nucleobase metabolic process [GO:0006206]; pyrimidine nucleoside biosynthetic process [GO:0046134]; small molecule metabolic process [GO:0044281]	DNA replication [GO:0006260]; dUMP biosynthetic process [GO:0006226]; dUTP catabolic process [GO:0046081]; nucleobase-containing compound metabolic process [GO:0006139]; nucleobase-containing small molecule metabolic process [GO:0055086]; pyrimidine nucleobase metabolic process [GO:0006206]; pyrimidine nucleoside biosynthetic process [GO:0046134]; small molecule metabolic process [GO:0044281]	dUTP diphosphatase activity [GO:0004170]; magnesium ion binding [GO:0000287]; poly(A) RNA binding [GO:0044822]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0006260; GO:0005737; GO:0006226; GO:0046081; GO:0004170; GO:0070062; GO:0000287; GO:0005739; GO:0006139; GO:0055086; GO:0005654; GO:0005634; GO:0044822; GO:0006206; GO:0046134; GO:0044281	SUBCELLULAR LOCATION: Isoform 2: Nucleus.; SUBCELLULAR LOCATION: Isoform 3: Mitochondrion.	3D-structure; Alternative splicing; Complete proteome; Direct protein sequencing; Hydrolase; Magnesium; Mitochondrion; Nucleotide metabolism; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transit peptide	Alternative sequence (1); Beta strand (14); Binding site (2); Chain (1); Frameshift (3); Helix (1); Modified residue (1); Mutagenesis (1); Natural variant (1); Region (3); Sequence conflict (2); Transit peptide (1); Turn (1)
CSN3_HUMAN	Q9UNS2	CSN3_HUMAN	reviewed	COP9 signalosome complex subunit 3 (SGN3) (Signalosome subunit 3) (JAB1-containing signalosome subunit 3)	COPS3 CSN3	Homo sapiens (Human)	423	COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cullin deneddylation [GO:0010388]; in utero embryonic development [GO:0001701]; response to light stimulus [GO:0009416]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process [GO:0006511]	cullin deneddylation [GO:0010388]; in utero embryonic development [GO:0001701]; response to light stimulus [GO:0009416]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process [GO:0006511]		COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0008180; GO:0010388; GO:0005737; GO:0001701; GO:0005654; GO:0005634; GO:0009416; GO:0007165; GO:0006511	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:9535219}.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome; Signalosome	Alternative sequence (1); Chain (1); Domain (1); Frameshift (1); Initiator methionine (1); Modified residue (3)
GKAP1_HUMAN	Q5VSY0	GKAP1_HUMAN	reviewed	G kinase-anchoring protein 1 (cGMP-dependent protein kinase-anchoring protein of 42 kDa)	GKAP1 GKAP42 FKSG21	Homo sapiens (Human)	366	Golgi apparatus [GO:0005794]; signal transduction [GO:0007165]	signal transduction [GO:0007165]		Golgi apparatus [GO:0005794]	GO:0005794; GO:0007165	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250}.	Alternative splicing; Coiled coil; Complete proteome; Golgi apparatus; Phosphoprotein; Reference proteome	Alternative sequence (1); Chain (1); Coiled coil (3); Erroneous gene model prediction (3); Erroneous initiation (1); Modified residue (2); Sequence conflict (1)
A6NEM2_HUMAN	A6NEM2	A6NEM2_HUMAN	unreviewed	Host cell factor 1	HCFC1	Homo sapiens (Human)	2080	mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]			mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	GO:0005739; GO:0005654		Complete proteome; Kelch repeat; Proteomics identification; Reference proteome	
EDC4_HUMAN	Q6P2E9	EDC4_HUMAN	reviewed	Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls)	EDC4 HEDLS	Homo sapiens (Human)	1401	cytoplasm [GO:0005737]; cytoplasmic mRNA processing body [GO:0000932]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [GO:0043928]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [GO:0043928]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]		cytoplasm [GO:0005737]; cytoplasmic mRNA processing body [GO:0000932]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005737; GO:0000932; GO:0005829; GO:0043928; GO:0010467; GO:0043231; GO:0016020; GO:0000288; GO:0005654; GO:0005634	SUBCELLULAR LOCATION: Cytoplasm, P-body. Nucleus.	Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat; WD repeat	Alternative sequence (1); Chain (1); Coiled coil (1); Compositional bias (1); Erroneous initiation (2); Frameshift (1); Initiator methionine (1); Modified residue (18); Region (1); Repeat (7); Sequence conflict (4)
RAGP1_HUMAN	P46060	RAGP1_HUMAN	reviewed	Ran GTPase-activating protein 1 (RanGAP1)	RANGAP1 KIAA1835 SD	Homo sapiens (Human)	587	condensed chromosome kinetochore [GO:0000777]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; perinuclear region of cytoplasm [GO:0048471]; spindle pole [GO:0000922]; GTPase activator activity [GO:0005096]; mitotic cell cycle [GO:0000278]; negative regulation of protein export from nucleus [GO:0046826]; positive regulation of GTPase activity [GO:0043547]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]	mitotic cell cycle [GO:0000278]; negative regulation of protein export from nucleus [GO:0046826]; positive regulation of GTPase activity [GO:0043547]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]	GTPase activator activity [GO:0005096]	condensed chromosome kinetochore [GO:0000777]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; perinuclear region of cytoplasm [GO:0048471]; spindle pole [GO:0000922]	GO:0005096; GO:0000777; GO:0005737; GO:0005829; GO:0000278; GO:0046826; GO:0031965; GO:0005643; GO:0048471; GO:0043547; GO:0007165; GO:0007264; GO:0000922	SUBCELLULAR LOCATION: Cytoplasm. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Chromosome, centromere, kinetochore {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Note=Cytoplasmic during interphase. Targeted to the nuclear rim after sumoylation. During mitosis, associates with mitotic spindles. Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase. Mitotic location also requires sumoylation.	3D-structure; Acetylation; Centromere; Chromosome; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; GTPase activation; Isopeptide bond; Kinetochore; Leucine-rich repeat; Membrane; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Ubl conjugation	Beta strand (2); Chain (1); Compositional bias (2); Cross-link (2); Erroneous initiation (1); Helix (11); Initiator methionine (1); Modified residue (8); Motif (1); Mutagenesis (1); Natural variant (1); Repeat (6); Site (2)
SYEP_HUMAN	P07814	SYEP_HUMAN	reviewed	Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) (Cell proliferation-inducing gene 32 protein) (Glutamatyl-prolyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase)]	EPRS GLNS PARS QARS QPRS PIG32	Homo sapiens (Human)	1512	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; GAIT complex [GO:0097452]; membrane [GO:0016020]; ribonucleoprotein complex [GO:0030529]; ATP binding [GO:0005524]; glutamate-tRNA ligase activity [GO:0004818]; GTPase binding [GO:0051020]; proline-tRNA ligase activity [GO:0004827]; RNA stem-loop binding [GO:0035613]; cellular response to interferon-gamma [GO:0071346]; gene expression [GO:0010467]; glutamyl-tRNA aminoacylation [GO:0006424]; negative regulation of translation [GO:0017148]; prolyl-tRNA aminoacylation [GO:0006433]; protein complex assembly [GO:0006461]; tRNA aminoacylation for protein translation [GO:0006418]	cellular response to interferon-gamma [GO:0071346]; gene expression [GO:0010467]; glutamyl-tRNA aminoacylation [GO:0006424]; negative regulation of translation [GO:0017148]; prolyl-tRNA aminoacylation [GO:0006433]; protein complex assembly [GO:0006461]; tRNA aminoacylation for protein translation [GO:0006418]	ATP binding [GO:0005524]; glutamate-tRNA ligase activity [GO:0004818]; GTPase binding [GO:0051020]; proline-tRNA ligase activity [GO:0004827]; RNA stem-loop binding [GO:0035613]	aminoacyl-tRNA synthetase multienzyme complex [GO:0017101]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; GAIT complex [GO:0097452]; membrane [GO:0016020]; ribonucleoprotein complex [GO:0030529]	GO:0005524; GO:0097452; GO:0051020; GO:0035613; GO:0017101; GO:0071346; GO:0005737; GO:0005829; GO:0010467; GO:0004818; GO:0006424; GO:0016020; GO:0017148; GO:0004827; GO:0006433; GO:0006461; GO:0030529; GO:0006418	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.	3D-structure; ATP-binding; Acetylation; Aminoacyl-tRNA synthetase; Complete proteome; Cytoplasm; Ligase; Multifunctional enzyme; Nucleotide-binding; Phosphoprotein; Polymorphism; Protein biosynthesis; RNA-binding; Reference proteome; Repeat; Translation regulation	Beta strand (28); Binding site (2); Chain (1); Domain (3); Erroneous initiation (2); Helix (18); Modified residue (18); Motif (2); Mutagenesis (4); Natural variant (8); Nucleotide binding (1); Region (4); Sequence caution (5); Sequence conflict (6); Turn (7)
XPO6_HUMAN	Q96QU8	XPO6_HUMAN	reviewed	Exportin-6 (Exp6) (Ran-binding protein 20)	XPO6 KIAA0370 RANBP20	Homo sapiens (Human)	1125	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein transporter activity [GO:0008565]; protein export from nucleus [GO:0006611]	protein export from nucleus [GO:0006611]	protein transporter activity [GO:0008565]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0005737; GO:0005730; GO:0005654; GO:0005634; GO:0005886; GO:0006611; GO:0008565	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.	Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport	Alternative sequence (1); Chain (1); Domain (1); Erroneous initiation (1); Initiator methionine (1); Modified residue (4); Natural variant (1); Sequence conflict (3)
ZW10_HUMAN	O43264	ZW10_HUMAN	reviewed	Centromere/kinetochore protein zw10 homolog	ZW10	Homo sapiens (Human)	779	condensed chromosome kinetochore [GO:0000777]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; membrane [GO:0016020]; nucleus [GO:0005634]; spindle pole [GO:0000922]; centromeric DNA binding [GO:0019237]; cell division [GO:0051301]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of mitotic spindle orientation [GO:0000132]; Golgi organization [GO:0007030]; meiotic nuclear division [GO:0007126]; mitotic cell cycle [GO:0000278]; mitotic cell cycle checkpoint [GO:0007093]; mitotic metaphase plate congression [GO:0007080]; mitotic sister chromatid segregation [GO:0000070]; protein complex assembly [GO:0006461]; protein localization to kinetochore [GO:0034501]; protein transport [GO:0015031]; regulation of exit from mitosis [GO:0007096]; small GTPase mediated signal transduction [GO:0007264]	cell division [GO:0051301]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of mitotic spindle orientation [GO:0000132]; Golgi organization [GO:0007030]; meiotic nuclear division [GO:0007126]; mitotic cell cycle [GO:0000278]; mitotic cell cycle checkpoint [GO:0007093]; mitotic metaphase plate congression [GO:0007080]; mitotic sister chromatid segregation [GO:0000070]; protein complex assembly [GO:0006461]; protein localization to kinetochore [GO:0034501]; protein transport [GO:0015031]; regulation of exit from mitosis [GO:0007096]; small GTPase mediated signal transduction [GO:0007264]	centromeric DNA binding [GO:0019237]	condensed chromosome kinetochore [GO:0000777]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; kinetochore [GO:0000776]; kinetochore microtubule [GO:0005828]; membrane [GO:0016020]; nucleus [GO:0005634]; spindle pole [GO:0000922]	GO:0006888; GO:0007030; GO:0051301; GO:0019237; GO:0000777; GO:0005737; GO:0005829; GO:0005783; GO:0005789; GO:0000132; GO:0000776; GO:0005828; GO:0007126; GO:0016020; GO:0000278; GO:0007093; GO:0007080; GO:0000070; GO:0005634; GO:0006461; GO:0034501; GO:0015031; GO:0007096; GO:0007264; GO:0000922	SUBCELLULAR LOCATION: Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Dynamic pattern of localization during the cell cycle. In most cells at interphase, present diffusely in the cytoplasm. In prometaphase, associated with the kinetochore. At metaphase, detected both at the kinetochores and, most prominently, at the spindle, particularly at the spindle poles. In very early anaphase, detected on segregating kinetochores. In late anaphase and telophase, accumulates at the spindle midzone.	Acetylation; Alternative splicing; Cell cycle; Cell division; Centromere; Chromosome; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; ER-Golgi transport; Endoplasmic reticulum; Kinetochore; Membrane; Mitosis; Polymorphism; Protein transport; Reference proteome; Transport	Alternative sequence (1); Chain (1); Coiled coil (1); Initiator methionine (1); Modified residue (2); Natural variant (1); Region (2)
TERA_HUMAN	P55072	TERA_HUMAN	reviewed	Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP)	VCP	Homo sapiens (Human)	806	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Hrd1p ubiquitin ligase complex [GO:0000836]; intracellular membrane-bounded organelle [GO:0043231]; lipid particle [GO:0005811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; proteasome complex [GO:0000502]; site of double-strand break [GO:0035861]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098]; VCP-NSFL1C complex [GO:1990730]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; deubiquitinase activator activity [GO:0035800]; lipid binding [GO:0008289]; poly(A) RNA binding [GO:0044822]; polyubiquitin binding [GO:0031593]; protein complex binding [GO:0032403]; protein domain specific binding [GO:0019904]; protein phosphatase binding [GO:0019903]; ubiquitin-like protein ligase binding [GO:0044389]; ubiquitin-specific protease binding [GO:1990381]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; aggresome assembly [GO:0070842]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to heat [GO:0034605]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; endoplasmic reticulum unfolded protein response [GO:0030968]; ER to Golgi vesicle-mediated transport [GO:0006888]; ER-associated misfolded protein catabolic process [GO:0071712]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; error-free translesion synthesis [GO:0070987]; establishment of protein localization [GO:0045184]; positive regulation of Lys63-specific deubiquitinase activity [GO:1903007]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein complex assembly [GO:0031334]; positive regulation of protein K63-linked deubiquitination [GO:1903006]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein hexamerization [GO:0034214]; protein homooligomerization [GO:0051260]; protein N-linked glycosylation via asparagine [GO:0018279]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; retrograde protein transport, ER to cytosol [GO:0030970]; translesion synthesis [GO:0019985]; viral genome replication [GO:0019079]	activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; aggresome assembly [GO:0070842]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to heat [GO:0034605]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; endoplasmic reticulum unfolded protein response [GO:0030968]; ER-associated misfolded protein catabolic process [GO:0071712]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; error-free translesion synthesis [GO:0070987]; ER to Golgi vesicle-mediated transport [GO:0006888]; establishment of protein localization [GO:0045184]; positive regulation of Lys63-specific deubiquitinase activity [GO:1903007]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein complex assembly [GO:0031334]; positive regulation of protein K63-linked deubiquitination [GO:1903006]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein hexamerization [GO:0034214]; protein homooligomerization [GO:0051260]; protein N-linked glycosylation via asparagine [GO:0018279]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; retrograde protein transport, ER to cytosol [GO:0030970]; translesion synthesis [GO:0019985]; viral genome replication [GO:0019079]	ADP binding [GO:0043531]; ATPase activity [GO:0016887]; ATP binding [GO:0005524]; deubiquitinase activator activity [GO:0035800]; lipid binding [GO:0008289]; poly(A) RNA binding [GO:0044822]; polyubiquitin binding [GO:0031593]; protein complex binding [GO:0032403]; protein domain specific binding [GO:0019904]; protein phosphatase binding [GO:0019903]; ubiquitin-like protein ligase binding [GO:0044389]; ubiquitin-specific protease binding [GO:1990381]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Hrd1p ubiquitin ligase complex [GO:0000836]; intracellular membrane-bounded organelle [GO:0043231]; lipid particle [GO:0005811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; proteasome complex [GO:0000502]; site of double-strand break [GO:0035861]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098]; VCP-NSFL1C complex [GO:1990730]	GO:0043531; GO:0005524; GO:0016887; GO:0006281; GO:0006888; GO:0071712; GO:0030433; GO:0000836; GO:0034098; GO:1990730; GO:0006919; GO:0070842; GO:0006974; GO:0034605; GO:0005737; GO:0005829; GO:0035800; GO:0006302; GO:0005783; GO:0005789; GO:0030968; GO:0070987; GO:0045184; GO:0070062; GO:0043231; GO:0008289; GO:0005811; GO:0005654; GO:0005634; GO:0048471; GO:0044822; GO:0031593; GO:1903007; GO:0032436; GO:1903006; GO:0045732; GO:0031334; GO:0000502; GO:0043161; GO:0018279; GO:0032403; GO:0019904; GO:0034214; GO:0051260; GO:0019903; GO:0016567; GO:0042981; GO:0030970; GO:0035861; GO:0019985; GO:0044389; GO:1990381; GO:0019079	SUBCELLULAR LOCATION: Cytoplasm, cytosol. Endoplasmic reticulum. Nucleus. Note=Present in the neuronal hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in neurons from Parkinson disease patients. Recruited to the cytoplasmic surface of the endoplasmic reticulum via interaction with AMFR/gp78. Following DNA double-strand breaks, recruited to the sites of damage. Recruited to stalled replication forks via interaction with SPRTN.	3D-structure; ATP-binding; Acetylation; Amyotrophic lateral sclerosis; Complete proteome; Cytoplasm; DNA damage; DNA repair; Direct protein sequencing; Disease mutation; Endoplasmic reticulum; Hydrolase; Lipid-binding; Methylation; Neurodegeneration; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Transport; Ubl conjugation; Ubl conjugation pathway	Beta strand (20); Binding site (2); Chain (1); Helix (25); Initiator methionine (1); Modified residue (14); Mutagenesis (14); Natural variant (9); Nucleotide binding (1); Region (1); Sequence conflict (2); Turn (4)
ECHM_HUMAN	P30084	ECHM_HUMAN	reviewed	Enoyl-CoA hydratase, mitochondrial (EC 4.2.1.17) (Enoyl-CoA hydratase 1) (Short-chain enoyl-CoA hydratase) (SCEH)	ECHS1	Homo sapiens (Human)	290	extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; enoyl-CoA hydratase activity [GO:0004300]; cellular lipid metabolic process [GO:0044255]; fatty acid beta-oxidation [GO:0006635]; small molecule metabolic process [GO:0044281]	cellular lipid metabolic process [GO:0044255]; fatty acid beta-oxidation [GO:0006635]; small molecule metabolic process [GO:0044281]	enoyl-CoA hydratase activity [GO:0004300]	extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0044255; GO:0004300; GO:0070062; GO:0006635; GO:0005759; GO:0005739; GO:0044281	SUBCELLULAR LOCATION: Mitochondrion matrix.	3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Disease mutation; Fatty acid metabolism; Lipid metabolism; Lyase; Mitochondrion; Neurodegeneration; Phosphoprotein; Polymorphism; Reference proteome; Transit peptide	Beta strand (10); Binding site (1); Chain (1); Helix (16); Modified residue (9); Natural variant (4); Region (1); Sequence conflict (5); Site (1); Transit peptide (1); Turn (3)
REL_HUMAN	Q04864	REL_HUMAN	reviewed	Proto-oncogene c-Rel	REL	Homo sapiens (Human)	619	cytosol [GO:0005829]; I-kappaB/NF-kappaB complex [GO:0033256]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor complex [GO:0005667]; chromatin binding [GO:0003682]; RNA polymerase II distal enhancer sequence-specific DNA binding [GO:0000980]; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [GO:0001205]; sequence-specific DNA binding transcription factor activity [GO:0003700]; cytokine production [GO:0001816]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of gene expression [GO:0010629]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of neuron death [GO:1901215]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; NIK/NF-kappaB signaling [GO:0038061]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interleukin-12 biosynthetic process [GO:0045084]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; response to cytokine [GO:0034097]	cytokine production [GO:0001816]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of gene expression [GO:0010629]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of neuron death [GO:1901215]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; NIK/NF-kappaB signaling [GO:0038061]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interleukin-12 biosynthetic process [GO:0045084]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; response to cytokine [GO:0034097]	chromatin binding [GO:0003682]; RNA polymerase II distal enhancer sequence-specific DNA binding [GO:0000980]; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [GO:0001205]; sequence-specific DNA binding transcription factor activity [GO:0003700]	cytosol [GO:0005829]; I-kappaB/NF-kappaB complex [GO:0033256]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor complex [GO:0005667]	GO:0007249; GO:0033256; GO:0038061; GO:0000980; GO:0001205; GO:0003682; GO:0001816; GO:0005829; GO:0006954; GO:0045087; GO:0010629; GO:0032688; GO:1901215; GO:0000122; GO:0005654; GO:0005634; GO:0043123; GO:0045084; GO:0045944; GO:0034097; GO:0003700; GO:0005667	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.	Acetylation; Activator; Alternative splicing; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Proto-oncogene; Reference proteome; Transcription; Transcription regulation	Alternative sequence (1); Chain (1); Domain (1); Initiator methionine (1); Modified residue (3); Motif (1)
A6NKB8_HUMAN	A6NKB8	A6NKB8_HUMAN	unreviewed	Aminopeptidase B	RNPEP	Homo sapiens (Human)	611	extracellular space [GO:0005615]; aminopeptidase activity [GO:0004177]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270]; leukotriene biosynthetic process [GO:0019370]	leukotriene biosynthetic process [GO:0019370]	aminopeptidase activity [GO:0004177]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270]	extracellular space [GO:0005615]	GO:0004177; GO:0005615; GO:0019370; GO:0008237; GO:0008270		Complete proteome; Proteomics identification; Reference proteome	
STMN1_HUMAN	P16949	STMN1_HUMAN	reviewed	Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Prosolin) (Protein Pr22) (pp17)	STMN1 C1orf215 LAP18 OP18	Homo sapiens (Human)	149	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular [GO:0005622]; membrane [GO:0016020]; microtubule [GO:0005874]; neuron projection [GO:0043005]; signal transducer activity [GO:0004871]; tubulin binding [GO:0015631]; axonogenesis [GO:0007409]; brain development [GO:0007420]; intracellular signal transduction [GO:0035556]; microtubule depolymerization [GO:0007019]; mitotic spindle organization [GO:0007052]; negative regulation of microtubule polymerization [GO:0031115]; neuron projection development [GO:0031175]; positive regulation of cellular component movement [GO:0051272]; regulation of cytoskeleton organization [GO:0051493]; response to virus [GO:0009615]; signal transduction [GO:0007165]	axonogenesis [GO:0007409]; brain development [GO:0007420]; intracellular signal transduction [GO:0035556]; microtubule depolymerization [GO:0007019]; mitotic spindle organization [GO:0007052]; negative regulation of microtubule polymerization [GO:0031115]; neuron projection development [GO:0031175]; positive regulation of cellular component movement [GO:0051272]; regulation of cytoskeleton organization [GO:0051493]; response to virus [GO:0009615]; signal transduction [GO:0007165]	signal transducer activity [GO:0004871]; tubulin binding [GO:0015631]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular [GO:0005622]; membrane [GO:0016020]; microtubule [GO:0005874]; neuron projection [GO:0043005]	GO:0007409; GO:0007420; GO:0005737; GO:0005829; GO:0070062; GO:0005622; GO:0035556; GO:0016020; GO:0005874; GO:0007019; GO:0007052; GO:0031115; GO:0043005; GO:0031175; GO:0051272; GO:0051493; GO:0009615; GO:0004871; GO:0007165; GO:0015631	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.	Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Differentiation; Direct protein sequencing; Microtubule; Neurogenesis; Phosphoprotein; Reference proteome	Alternative sequence (1); Chain (1); Coiled coil (1); Domain (1); Initiator methionine (1); Modified residue (9)
SYMPK_HUMAN	Q92797	SYMPK_HUMAN	reviewed	Symplekin	SYMPK SPK	Homo sapiens (Human)	1274	bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; cell adhesion [GO:0007155]; mRNA polyadenylation [GO:0006378]; positive regulation of protein dephosphorylation [GO:0035307]	cell adhesion [GO:0007155]; mRNA polyadenylation [GO:0006378]; positive regulation of protein dephosphorylation [GO:0035307]		bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	GO:0005923; GO:0007155; GO:0005737; GO:0005856; GO:0006378; GO:0005654; GO:0005886; GO:0035307	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell junction, tight junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Nucleus, nucleoplasm. Note=Cytoplasmic face of adhesion plaques (major) and nucleoplasm (minor) (in cells with TJ). Nucleoplasm (in cells without TJ). Nuclear bodies of heat-stressed cells.	3D-structure; Alternative splicing; Cell adhesion; Cell junction; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Membrane; Nucleus; Phosphoprotein; Reference proteome; Repeat; Tight junction; mRNA processing	Alternative sequence (2); Beta strand (1); Chain (1); Compositional bias (1); Erroneous initiation (2); Frameshift (1); Helix (25); Modified residue (6); Motif (1); Mutagenesis (1); Region (1); Repeat (5); Sequence caution (1)
EF1A1_HUMAN	P68104	EF1A1_HUMAN	reviewed	Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7)	EEF1A1 EEF1A EF1A LENG7	Homo sapiens (Human)	462	cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation elongation factor 1 complex [GO:0005853]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ruffle membrane [GO:0032587]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; poly(A) RNA binding [GO:0044822]; protein kinase binding [GO:0019901]; translation elongation factor activity [GO:0003746]; tRNA binding [GO:0000049]; cellular protein metabolic process [GO:0044267]; cellular response to epidermal growth factor stimulus [GO:0071364]; gene expression [GO:0010467]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]; translation [GO:0006412]; translational elongation [GO:0006414]	cellular protein metabolic process [GO:0044267]; cellular response to epidermal growth factor stimulus [GO:0071364]; gene expression [GO:0010467]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]; translation [GO:0006412]; translational elongation [GO:0006414]	GTPase activity [GO:0003924]; GTP binding [GO:0005525]; poly(A) RNA binding [GO:0044822]; protein kinase binding [GO:0019901]; translation elongation factor activity [GO:0003746]; tRNA binding [GO:0000049]	cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation elongation factor 1 complex [GO:0005853]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ruffle membrane [GO:0032587]	GO:0005525; GO:0003924; GO:0044267; GO:0071364; GO:0030864; GO:0005737; GO:0005829; GO:0005853; GO:0070062; GO:0005615; GO:0010467; GO:0016020; GO:0005730; GO:0005634; GO:0044822; GO:0019901; GO:0006355; GO:0032587; GO:0000049; GO:0006351; GO:0006412; GO:0003746; GO:0006414	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Colocalizes with DLC1 at actin-rich regions in the cell periphery. Translocates together with ZPR1 from the cytoplasm to the nucleus and nucleolus after treatment with mitogens.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Elongation factor; GTP-binding; Methylation; Nucleotide-binding; Nucleus; Phosphoprotein; Protein biosynthesis; Reference proteome; Transcription; Transcription regulation; Ubl conjugation	Alternative sequence (1); Chain (1); Domain (1); Erroneous initiation (1); Modified residue (18); Mutagenesis (1); Nucleotide binding (3); Region (5); Sequence conflict (2)
COF1_HUMAN	P23528	COF1_HUMAN	reviewed	Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)	CFL1 CFL	Homo sapiens (Human)	166	cell-cell junction [GO:0005911]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; lamellipodium membrane [GO:0031258]; membrane [GO:0016020]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; ruffle membrane [GO:0032587]; vesicle [GO:0031982]; actin cytoskeleton organization [GO:0030036]; actin filament depolymerization [GO:0030042]; axon guidance [GO:0007411]; blood coagulation [GO:0007596]; cytoskeleton organization [GO:0007010]; ephrin receptor signaling pathway [GO:0048013]; establishment of cell polarity [GO:0030010]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; innate immune response [GO:0045087]; mitotic cytokinesis [GO:0000281]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell size [GO:0045792]; neural crest cell migration [GO:0001755]; neural fold formation [GO:0001842]; platelet activation [GO:0030168]; platelet degranulation [GO:0002576]; positive regulation of actin filament depolymerization [GO:0030836]; protein import into nucleus [GO:0006606]; protein phosphorylation [GO:0006468]; regulation of cell morphogenesis [GO:0022604]; regulation of dendritic spine morphogenesis [GO:0061001]; response to amino acid [GO:0043200]; response to virus [GO:0009615]; Rho protein signal transduction [GO:0007266]	actin cytoskeleton organization [GO:0030036]; actin filament depolymerization [GO:0030042]; axon guidance [GO:0007411]; blood coagulation [GO:0007596]; cytoskeleton organization [GO:0007010]; ephrin receptor signaling pathway [GO:0048013]; establishment of cell polarity [GO:0030010]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; innate immune response [GO:0045087]; mitotic cytokinesis [GO:0000281]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell size [GO:0045792]; neural crest cell migration [GO:0001755]; neural fold formation [GO:0001842]; platelet activation [GO:0030168]; platelet degranulation [GO:0002576]; positive regulation of actin filament depolymerization [GO:0030836]; protein import into nucleus [GO:0006606]; protein phosphorylation [GO:0006468]; regulation of cell morphogenesis [GO:0022604]; regulation of dendritic spine morphogenesis [GO:0061001]; response to amino acid [GO:0043200]; response to virus [GO:0009615]; Rho protein signal transduction [GO:0007266]		cell-cell junction [GO:0005911]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; lamellipodium membrane [GO:0031258]; membrane [GO:0016020]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; ruffle membrane [GO:0032587]; vesicle [GO:0031982]	GO:0038096; GO:0007266; GO:0030036; GO:0030042; GO:0007411; GO:0007596; GO:0005911; GO:0030864; GO:0005737; GO:0007010; GO:0048013; GO:0030010; GO:0070062; GO:0005615; GO:0005925; GO:0045087; GO:0031258; GO:0016020; GO:0000281; GO:0043066; GO:0045792; GO:0001755; GO:0001842; GO:0016363; GO:0005634; GO:0030168; GO:0002576; GO:0030836; GO:0006606; GO:0006468; GO:0022604; GO:0061001; GO:0043200; GO:0009615; GO:0032587; GO:0031982	SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000269|PubMed:15580268}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15580268}. Cell projection, ruffle membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:15580268}; Peripheral membrane protein {ECO:0000269|PubMed:15580268}; Cytoplasmic side {ECO:0000269|PubMed:15580268}. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.	3D-structure; Acetylation; Actin-binding; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Membrane; Nucleus; Phosphoprotein; Reference proteome	Beta strand (8); Chain (1); Domain (1); Helix (9); Initiator methionine (1); Modified residue (10); Motif (1); Turn (1)
F6RFD5_HUMAN	F6RFD5	F6RFD5_HUMAN	unreviewed	Destrin	DSTN	Homo sapiens (Human)	135	actin cytoskeleton [GO:0015629]; actin filament depolymerization [GO:0030042]; actin filament severing [GO:0051014]; positive regulation of actin filament depolymerization [GO:0030836]	actin filament depolymerization [GO:0030042]; actin filament severing [GO:0051014]; positive regulation of actin filament depolymerization [GO:0030836]		actin cytoskeleton [GO:0015629]	GO:0015629; GO:0030042; GO:0051014; GO:0030836		Actin-binding; Complete proteome; Proteomics identification; Reference proteome	
PSME3_HUMAN	P61289	PSME3_HUMAN	reviewed	Proteasome activator complex subunit 3 (11S regulator complex subunit gamma) (REG-gamma) (Activator of multicatalytic protease subunit 3) (Ki nuclear autoantigen) (Proteasome activator 28 subunit gamma) (PA28g) (PA28gamma)	PSME3	Homo sapiens (Human)	254	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome activator complex [GO:0008537]; proteasome complex [GO:0000502]; endopeptidase activator activity [GO:0061133]; identical protein binding [GO:0042802]; MDM2/MDM4 family protein binding [GO:0097371]; p53 binding [GO:0002039]; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of endopeptidase activity [GO:0010950]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of proteasomal protein catabolic process [GO:0061136]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of endopeptidase activity [GO:0010950]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of proteasomal protein catabolic process [GO:0061136]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	endopeptidase activator activity [GO:0061133]; identical protein binding [GO:0042802]; MDM2/MDM4 family protein binding [GO:0097371]; p53 binding [GO:0002039]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome activator complex [GO:0008537]; proteasome complex [GO:0000502]	GO:0006977; GO:0000082; GO:0097371; GO:0031145; GO:0042590; GO:0002479; GO:0002474; GO:0006915; GO:0034641; GO:0005737; GO:0005829; GO:0061133; GO:0010467; GO:0042802; GO:0045087; GO:0016020; GO:0000278; GO:0043066; GO:0090090; GO:2001237; GO:0051436; GO:0005654; GO:0005634; GO:0002039; GO:0090263; GO:0010950; GO:0051437; GO:0012501; GO:0008537; GO:0000502; GO:0000209; GO:0042981; GO:0006521; GO:0061136; GO:0051439; GO:0044281; GO:0002223; GO:0016032	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10657252, ECO:0000269|PubMed:12629132}. Cytoplasm {ECO:0000250}. Note=Localizes to the cytoplasm during mitosis following nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3 kinase. {ECO:0000250}.	Acetylation; Alternative splicing; Apoptosis; Cell cycle; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Phosphoprotein; Proteasome; Reference proteome	Alternative sequence (2); Chain (1); Initiator methionine (1); Modified residue (4); Mutagenesis (1); Sequence conflict (2)
K7ESG5_HUMAN	K7ESG5	K7ESG5_HUMAN	unreviewed	Proteasome activator complex subunit 3	PSME3	Homo sapiens (Human)	198	proteasome activator complex [GO:0008537]			proteasome activator complex [GO:0008537]	GO:0008537		Complete proteome; Proteomics identification; Reference proteome	
DCTN4_HUMAN	Q9UJW0	DCTN4_HUMAN	reviewed	Dynactin subunit 4 (Dyn4) (Dynactin subunit p62)	DCTN4	Homo sapiens (Human)	460	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; cytosol [GO:0005829]; dynactin complex [GO:0005869]; nucleus [GO:0005634]; protein N-terminus binding [GO:0047485]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; nuclear migration [GO:0007097]	antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; nuclear migration [GO:0007097]	protein N-terminus binding [GO:0047485]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; cytosol [GO:0005829]; dynactin complex [GO:0005869]; nucleus [GO:0005634]	GO:0019886; GO:0005813; GO:0005737; GO:0005868; GO:0005829; GO:0005869; GO:0007097; GO:0005634; GO:0047485	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10671518}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:10671518}. Note=In skeletal muscles, demonstrates a punctate distribution along costameres (By similarity). Has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin. Overexpression does not disrupt microtubule organization or the integrity of the Golgi but does cause both cytosolic and nuclear distribution, suggesting that this polypeptide may be targeted to the nucleus at very high expression levels. {ECO:0000250}.	Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Polymorphism; Reference proteome	Alternative sequence (2); Chain (1); Coiled coil (1); Initiator methionine (1); Modified residue (2); Mutagenesis (12); Natural variant (4)
TCPB_HUMAN	P78371	TCPB_HUMAN	reviewed	T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta)	CCT2 99D8.1 CCTB	Homo sapiens (Human)	535	cell body [GO:0044297]; chaperonin-containing T-complex [GO:0005832]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]; zona pellucida receptor complex [GO:0002199]; ATP binding [GO:0005524]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]; 'de novo' posttranslational protein folding [GO:0051084]; binding of sperm to zona pellucida [GO:0007339]; cellular protein metabolic process [GO:0044267]; chaperone-mediated protein complex assembly [GO:0051131]; protein folding [GO:0006457]; toxin transport [GO:1901998]	'de novo' posttranslational protein folding [GO:0051084]; binding of sperm to zona pellucida [GO:0007339]; cellular protein metabolic process [GO:0044267]; chaperone-mediated protein complex assembly [GO:0051131]; protein folding [GO:0006457]; toxin transport [GO:1901998]	ATP binding [GO:0005524]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]	cell body [GO:0044297]; chaperonin-containing T-complex [GO:0005832]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]; zona pellucida receptor complex [GO:0002199]	GO:0051084; GO:0005524; GO:0007339; GO:0044297; GO:0044267; GO:0051131; GO:0005832; GO:0005737; GO:0005829; GO:0070062; GO:0005874; GO:0006457; GO:1901998; GO:0031625; GO:0051082; GO:0002199	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20080638}.	ATP-binding; Acetylation; Alternative splicing; Chaperone; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleotide-binding; Phosphoprotein; Reference proteome	Alternative sequence (1); Chain (1); Initiator methionine (1); Modified residue (7); Sequence conflict (7)
CBX3_HUMAN	Q13185	CBX3_HUMAN	reviewed	Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein)	CBX3	Homo sapiens (Human)	183	chromatin [GO:0000785]; chromosome, centromeric region [GO:0000775]; condensed chromosome, centromeric region [GO:0000779]; nuclear envelope [GO:0005635]; nuclear euchromatin [GO:0005719]; nuclear heterochromatin [GO:0005720]; nuclear inner membrane [GO:0005637]; nuclear pericentric heterochromatin [GO:0031618]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; enzyme binding [GO:0019899]; histone methyltransferase binding [GO:1990226]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]; chromatin remodeling [GO:0006338]; negative regulation of transcription, DNA-templated [GO:0045892]; rhythmic process [GO:0048511]; transcription, DNA-templated [GO:0006351]	chromatin remodeling [GO:0006338]; negative regulation of transcription, DNA-templated [GO:0045892]; rhythmic process [GO:0048511]; transcription, DNA-templated [GO:0006351]	enzyme binding [GO:0019899]; histone methyltransferase binding [GO:1990226]; identical protein binding [GO:0042802]; protein domain specific binding [GO:0019904]	chromatin [GO:0000785]; chromosome, centromeric region [GO:0000775]; condensed chromosome, centromeric region [GO:0000779]; nuclear envelope [GO:0005635]; nuclear euchromatin [GO:0005719]; nuclear heterochromatin [GO:0005720]; nuclear inner membrane [GO:0005637]; nuclear pericentric heterochromatin [GO:0031618]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]	GO:0000785; GO:0006338; GO:0000775; GO:0000779; GO:0019899; GO:1990226; GO:0042802; GO:0045892; GO:0005635; GO:0005719; GO:0005720; GO:0005637; GO:0031618; GO:0005654; GO:0005634; GO:0019904; GO:0048511; GO:0005819; GO:0006351	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Note=Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis (Potential). {ECO:0000305}.	3D-structure; Acetylation; Biological rhythms; Chromatin regulator; Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation	Beta strand (6); Chain (1); Domain (2); Helix (6); Initiator methionine (1); Modified residue (10); Sequence conflict (4)
FLNB_HUMAN	O75369	FLNB_HUMAN	reviewed	Filamin-B (FLN-B) (ABP-278) (ABP-280 homolog) (Actin-binding-like protein) (Beta-filamin) (Filamin homolog 1) (Fh1) (Filamin-3) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP)	FLNB FLN1L FLN3 TABP TAP	Homo sapiens (Human)	2602	actin cytoskeleton [GO:0015629]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]; Z disc [GO:0030018]; actin binding [GO:0003779]; identical protein binding [GO:0042802]; poly(A) RNA binding [GO:0044822]; actin cytoskeleton organization [GO:0030036]; cell differentiation [GO:0030154]; cytokine-mediated signaling pathway [GO:0019221]; cytoskeletal anchoring at plasma membrane [GO:0007016]; signal transduction [GO:0007165]; skeletal muscle tissue development [GO:0007519]	actin cytoskeleton organization [GO:0030036]; cell differentiation [GO:0030154]; cytokine-mediated signaling pathway [GO:0019221]; cytoskeletal anchoring at plasma membrane [GO:0007016]; signal transduction [GO:0007165]; skeletal muscle tissue development [GO:0007519]	actin binding [GO:0003779]; identical protein binding [GO:0042802]; poly(A) RNA binding [GO:0044822]	actin cytoskeleton [GO:0015629]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]; Z disc [GO:0030018]	GO:0030018; GO:0003779; GO:0015629; GO:0030036; GO:0005938; GO:0030154; GO:0019221; GO:0005737; GO:0007016; GO:0005829; GO:0070062; GO:0005925; GO:0042802; GO:0016021; GO:0005886; GO:0044822; GO:0007165; GO:0007519; GO:0001725	SUBCELLULAR LOCATION: Isoform 1: Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Note=In differentiating myotubes, isoform 1, isoform 2 and isoform 3 are localized diffusely throughout the cytoplasm with regions of enrichment at the longitudinal actin stress fiber. In differentiated tubes, isoform 1 is also detected within the Z-lines.; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm, cytoskeleton. Note=Predominantly localized at actin stress fibers.; SUBCELLULAR LOCATION: Isoform 3: Cytoplasm, cytoskeleton. Note=Predominantly localized at actin stress fibers.; SUBCELLULAR LOCATION: Isoform 6: Cytoplasm, cytoskeleton. Note=Polarized at the periphery of myotubes.	3D-structure; Acetylation; Actin-binding; Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Differentiation; Disease mutation; Dwarfism; Isopeptide bond; Myogenesis; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Ubl conjugation	Alternative sequence (10); Beta strand (131); Chain (1); Cross-link (1); Domain (3); Frameshift (1); Helix (32); Modified residue (25); Mutagenesis (1); Natural variant (27); Region (8); Repeat (24); Sequence conflict (13); Turn (16)
MAGD4_HUMAN	Q96JG8	MAGD4_HUMAN	reviewed	Melanoma-associated antigen D4 (MAGE-D4 antigen) (MAGE-E1 antigen)	MAGED4 KIAA1859 MAGED4A MAGEE1; MAGED4B	Homo sapiens (Human)	741							Alternative splicing; Complete proteome; Reference proteome; Tumor antigen; Ubl conjugation pathway	Alternative sequence (4); Chain (1); Compositional bias (1); Domain (1); Erroneous initiation (2); Frameshift (1); Sequence conflict (2)
VATG1_HUMAN	O75348	VATG1_HUMAN	reviewed	V-type proton ATPase subunit G 1 (V-ATPase subunit G 1) (V-ATPase 13 kDa subunit 1) (Vacuolar proton pump subunit G 1) (Vacuolar proton pump subunit M16)	ATP6V1G1 ATP6G ATP6G1 ATP6J	Homo sapiens (Human)	118	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; ATPase binding [GO:0051117]; hydrogen-exporting ATPase activity, phosphorylative mechanism [GO:0008553]; cellular iron ion homeostasis [GO:0006879]; insulin receptor signaling pathway [GO:0008286]; interaction with host [GO:0051701]; ion transmembrane transport [GO:0034220]; phagosome maturation [GO:0090382]; transferrin transport [GO:0033572]; transmembrane transport [GO:0055085]	cellular iron ion homeostasis [GO:0006879]; insulin receptor signaling pathway [GO:0008286]; interaction with host [GO:0051701]; ion transmembrane transport [GO:0034220]; phagosome maturation [GO:0090382]; transferrin transport [GO:0033572]; transmembrane transport [GO:0055085]	ATPase binding [GO:0051117]; hydrogen-exporting ATPase activity, phosphorylative mechanism [GO:0008553]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]	GO:0051117; GO:0006879; GO:0005829; GO:0070062; GO:0008553; GO:0008286; GO:0051701; GO:0034220; GO:0005765; GO:0090382; GO:0005886; GO:0033572; GO:0055085; GO:0016471		Acetylation; Complete proteome; Direct protein sequencing; Hydrogen ion transport; Ion transport; Reference proteome; Transport	Chain (1); Initiator methionine (1); Modified residue (1)
H0Y4X3_HUMAN	H0Y4X3	H0Y4X3_HUMAN	unreviewed	RNA-binding protein 39 (Fragment)	RBM39	Homo sapiens (Human)	337	nucleus [GO:0005634]; nucleotide binding [GO:0000166]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]	mRNA processing [GO:0006397]	nucleotide binding [GO:0000166]; RNA binding [GO:0003723]	nucleus [GO:0005634]	GO:0003723; GO:0006397; GO:0000166; GO:0005634		Complete proteome; Proteomics identification; Reference proteome	Non-terminal residue (2)
BPNT1_HUMAN	O95861	BPNT1_HUMAN	reviewed	3'(2'),5'-bisphosphate nucleotidase 1 (EC 3.1.3.7) (Bisphosphate 3'-nucleotidase 1) (PAP-inositol 1,4-phosphatase) (PIP)	BPNT1	Homo sapiens (Human)	308	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; 3'(2'),5'-bisphosphate nucleotidase activity [GO:0008441]; inositol-1,4-bisphosphate 1-phosphatase activity [GO:0004441]; magnesium ion binding [GO:0000287]; 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; dephosphorylation [GO:0016311]; nervous system development [GO:0007399]; nucleobase-containing compound metabolic process [GO:0006139]; phosphatidylinositol phosphorylation [GO:0046854]; small molecule metabolic process [GO:0044281]; xenobiotic metabolic process [GO:0006805]	3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; dephosphorylation [GO:0016311]; nervous system development [GO:0007399]; nucleobase-containing compound metabolic process [GO:0006139]; phosphatidylinositol phosphorylation [GO:0046854]; small molecule metabolic process [GO:0044281]; xenobiotic metabolic process [GO:0006805]	3'(2'),5'-bisphosphate nucleotidase activity [GO:0008441]; inositol-1,4-bisphosphate 1-phosphatase activity [GO:0004441]; magnesium ion binding [GO:0000287]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0008441; GO:0050427; GO:0005829; GO:0016311; GO:0070062; GO:0004441; GO:0000287; GO:0007399; GO:0006139; GO:0046854; GO:0044281; GO:0006805		3D-structure; Acetylation; Alternative splicing; Complete proteome; Hydrolase; Lithium; Magnesium; Metal-binding; Phosphoprotein; Reference proteome	Alternative sequence (3); Beta strand (14); Binding site (2); Chain (1); Helix (13); Initiator methionine (1); Metal binding (6); Modified residue (3); Region (2); Sequence conflict (2); Turn (2)
NC2B_HUMAN	Q01658	NC2B_HUMAN	reviewed	Protein Dr1 (Down-regulator of transcription 1) (Negative cofactor 2-beta) (NC2-beta) (TATA-binding protein-associated phosphoprotein)	DR1	Homo sapiens (Human)	176	Ada2/Gcn5/Ada3 transcription activator complex [GO:0005671]; nucleus [GO:0005634]; DNA binding [GO:0003677]; sequence-specific DNA binding [GO:0043565]; TBP-class protein binding [GO:0017025]; transcription corepressor activity [GO:0003714]; transcription factor binding [GO:0008134]; chromatin organization [GO:0006325]; histone H3 acetylation [GO:0043966]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription, DNA-templated [GO:0006351]	chromatin organization [GO:0006325]; histone H3 acetylation [GO:0043966]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; transcription, DNA-templated [GO:0006351]	DNA binding [GO:0003677]; sequence-specific DNA binding [GO:0043565]; TBP-class protein binding [GO:0017025]; transcription corepressor activity [GO:0003714]; transcription factor binding [GO:0008134]	Ada2/Gcn5/Ada3 transcription activator complex [GO:0005671]; nucleus [GO:0005634]	GO:0005671; GO:0003677; GO:0017025; GO:0006325; GO:0043966; GO:0000122; GO:0005634; GO:0043565; GO:0003714; GO:0008134; GO:0006351	SUBCELLULAR LOCATION: Nucleus.	3D-structure; Acetylation; Complete proteome; DNA-binding; Direct protein sequencing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repressor; Transcription; Transcription regulation	Beta strand (2); Chain (1); Compositional bias (1); Helix (6); Initiator methionine (1); Modified residue (3); Motif (1); Natural variant (1)
HDDC2_HUMAN	Q7Z4H3	HDDC2_HUMAN	reviewed	HD domain-containing protein 2 (Hepatitis C virus NS5A-transactivated protein 2) (HCV NS5A-transactivated protein 2)	HDDC2 C6orf74 NS5ATP2 CGI-130	Homo sapiens (Human)	204	extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]			extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]	GO:0070062; GO:0005739		3D-structure; Acetylation; Alternative splicing; Complete proteome; Polymorphism; Reference proteome	Alternative sequence (3); Chain (1); Domain (1); Erroneous initiation (1); Helix (12); Initiator methionine (1); Modified residue (1); Natural variant (1); Sequence caution (1); Sequence conflict (2); Turn (3)
Q5SQQ1_HUMAN	Q5SQQ1	Q5SQQ1_HUMAN	unreviewed	Arginyl-tRNA--protein transferase 1 (Fragment)	ATE1	Homo sapiens (Human)	222	arginyltransferase activity [GO:0004057]; protein arginylation [GO:0016598]	protein arginylation [GO:0016598]	arginyltransferase activity [GO:0004057]		GO:0004057; GO:0016598		Complete proteome; Proteomics identification; Reference proteome	Non-terminal residue (1)
DRG1_HUMAN	Q9Y295	DRG1_HUMAN	reviewed	Developmentally-regulated GTP-binding protein 1 (DRG-1) (Neural precursor cell expressed developmentally down-regulated protein 3) (NEDD-3)	DRG1 NEDD3	Homo sapiens (Human)	367	cytoplasm [GO:0005737]; membrane [GO:0016020]; polysome [GO:0005844]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; transcription factor binding [GO:0008134]; multicellular organismal development [GO:0007275]; transcription, DNA-templated [GO:0006351]	multicellular organismal development [GO:0007275]; transcription, DNA-templated [GO:0006351]	GTP binding [GO:0005525]; identical protein binding [GO:0042802]; transcription factor binding [GO:0008134]	cytoplasm [GO:0005737]; membrane [GO:0016020]; polysome [GO:0005844]	GO:0005525; GO:0005737; GO:0042802; GO:0016020; GO:0007275; GO:0005844; GO:0008134; GO:0006351	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15676025, ECO:0000269|PubMed:19819225}. Note=The DRG1-DFRP2/ZC3H15 complex associates with polysomes.	3D-structure; Acetylation; Complete proteome; Cytoplasm; GTP-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Ubl conjugation	Beta strand (7); Chain (1); Compositional bias (1); Domain (1); Helix (1); Initiator methionine (1); Modified residue (2); Nucleotide binding (3); Region (1); Sequence conflict (1); Turn (1)
E9PBS1_HUMAN	E9PBS1	E9PBS1_HUMAN	unreviewed	Multifunctional protein ADE2 (Fragment)	PAICS	Homo sapiens (Human)	413	ATP binding [GO:0005524]; phosphoribosylaminoimidazolesuccinocarboxamide synthase activity [GO:0004639]; 'de novo' IMP biosynthetic process [GO:0006189]	'de novo' IMP biosynthetic process [GO:0006189]	ATP binding [GO:0005524]; phosphoribosylaminoimidazolesuccinocarboxamide synthase activity [GO:0004639]		GO:0006189; GO:0005524; GO:0004639		Complete proteome; Proteomics identification; Reference proteome	Non-terminal residue (1)
LMNB1_HUMAN	P20700	LMNB1_HUMAN	reviewed	Lamin-B1	LMNB1 LMN2 LMNB	Homo sapiens (Human)	586	lamin filament [GO:0005638]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; structural molecule activity [GO:0005198]; apoptotic process [GO:0006915]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; programmed cell death [GO:0012501]	apoptotic process [GO:0006915]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; programmed cell death [GO:0012501]	structural molecule activity [GO:0005198]	lamin filament [GO:0005638]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear inner membrane [GO:0005637]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]	GO:0006915; GO:0006921; GO:0005638; GO:0016020; GO:0005635; GO:0005637; GO:0031965; GO:0005654; GO:0012501; GO:0005198	SUBCELLULAR LOCATION: Nucleus inner membrane; Lipid-anchor; Nucleoplasmic side.	3D-structure; Acetylation; Chromosomal rearrangement; Coiled coil; Complete proteome; Direct protein sequencing; Disulfide bond; Intermediate filament; Leukodystrophy; Lipoprotein; Membrane; Methylation; Nucleus; Phosphoprotein; Polymorphism; Prenylation; Reference proteome	Beta strand (10); Chain (1); Compositional bias (1); Disulfide bond (1); Domain (1); Helix (1); Initiator methionine (1); Lipidation (1); Modified residue (14); Motif (1); Natural variant (2); Propeptide (1); Region (8); Sequence conflict (1); Turn (1)
NEDD4_HUMAN	P46934	NEDD4_HUMAN	reviewed	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Cell proliferation-inducing gene 53 protein) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)	NEDD4 KIAA0093 NEDD4-1 PIG53	Homo sapiens (Human)	1319	apicolateral plasma membrane [GO:0016327]; cell cortex [GO:0005938]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151]; beta-2 adrenergic receptor binding [GO:0031698]; ligase activity [GO:0016874]; phosphoserine binding [GO:0050815]; phosphothreonine binding [GO:0050816]; proline-rich region binding [GO:0070064]; protein domain specific binding [GO:0019904]; RNA polymerase binding [GO:0070063]; sodium channel inhibitor activity [GO:0019871]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; adaptive immune response [GO:0002250]; blood vessel morphogenesis [GO:0048514]; cellular response to UV [GO:0034644]; cytokine-mediated signaling pathway [GO:0019221]; development involved in symbiotic interaction [GO:0044111]; endocardial cushion development [GO:0003197]; glucocorticoid receptor signaling pathway [GO:0042921]; lysosomal transport [GO:0007041]; negative regulation of sodium ion transmembrane transporter activity [GO:2000650]; negative regulation of sodium ion transport [GO:0010766]; negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage [GO:0010768]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; neuromuscular junction development [GO:0007528]; neuron projection development [GO:0031175]; outflow tract morphogenesis [GO:0003151]; positive regulation of nucleocytoplasmic transport [GO:0046824]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of protein catabolic process [GO:0045732]; progesterone receptor signaling pathway [GO:0050847]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; protein targeting to lysosome [GO:0006622]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; receptor catabolic process [GO:0032801]; receptor internalization [GO:0031623]; regulation of dendrite morphogenesis [GO:0048814]; regulation of ion transmembrane transport [GO:0034765]; regulation of membrane potential [GO:0042391]; regulation of potassium ion transmembrane transporter activity [GO:1901016]; regulation of synapse organization [GO:0050807]; response to calcium ion [GO:0051592]; T cell activation [GO:0042110]; transmission of virus [GO:0019089]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]	adaptive immune response [GO:0002250]; blood vessel morphogenesis [GO:0048514]; cellular response to UV [GO:0034644]; cytokine-mediated signaling pathway [GO:0019221]; development involved in symbiotic interaction [GO:0044111]; endocardial cushion development [GO:0003197]; glucocorticoid receptor signaling pathway [GO:0042921]; lysosomal transport [GO:0007041]; negative regulation of sodium ion transmembrane transporter activity [GO:2000650]; negative regulation of sodium ion transport [GO:0010766]; negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage [GO:0010768]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; neuromuscular junction development [GO:0007528]; neuron projection development [GO:0031175]; outflow tract morphogenesis [GO:0003151]; positive regulation of nucleocytoplasmic transport [GO:0046824]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of protein catabolic process [GO:0045732]; progesterone receptor signaling pathway [GO:0050847]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; protein targeting to lysosome [GO:0006622]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; receptor catabolic process [GO:0032801]; receptor internalization [GO:0031623]; regulation of dendrite morphogenesis [GO:0048814]; regulation of ion transmembrane transport [GO:0034765]; regulation of membrane potential [GO:0042391]; regulation of potassium ion transmembrane transporter activity [GO:1901016]; regulation of synapse organization [GO:0050807]; response to calcium ion [GO:0051592]; T cell activation [GO:0042110]; transmission of virus [GO:0019089]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]	beta-2 adrenergic receptor binding [GO:0031698]; ligase activity [GO:0016874]; phosphoserine binding [GO:0050815]; phosphothreonine binding [GO:0050816]; proline-rich region binding [GO:0070064]; protein domain specific binding [GO:0019904]; RNA polymerase binding [GO:0070063]; sodium channel inhibitor activity [GO:0019871]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]	apicolateral plasma membrane [GO:0016327]; cell cortex [GO:0005938]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151]	GO:0005794; GO:0070063; GO:0042110; GO:0002250; GO:0016327; GO:0031698; GO:0048514; GO:0005938; GO:0034644; GO:0000785; GO:0019221; GO:0005737; GO:0005829; GO:0044111; GO:0003197; GO:0070062; GO:0042921; GO:0016874; GO:0007041; GO:2000650; GO:0010766; GO:0010768; GO:0030948; GO:0007528; GO:0031175; GO:0003151; GO:0048471; GO:0050815; GO:0050816; GO:0005886; GO:0046824; GO:0014068; GO:0045732; GO:0050847; GO:0070064; GO:0070534; GO:0019904; GO:0006513; GO:0006622; GO:0016567; GO:0042787; GO:0032801; GO:0031623; GO:0048814; GO:0034765; GO:0042391; GO:1901016; GO:0050807; GO:0051592; GO:0019871; GO:0019089; GO:0043130; GO:0000151; GO:0061630; GO:0043162	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Recruited to the plasma membrane by GRB10. Once complexed with GRB10 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the sorting of the receptor to the lysosomal compartment (By similarity). May be recruited to exosomes by NDFIP1. {ECO:0000250, ECO:0000269|PubMed:18819914}.	3D-structure; Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Host-virus interaction; Ligase; Membrane; Neurogenesis; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Ubl conjugation; Ubl conjugation pathway	Active site (1); Alternative sequence (4); Beta strand (21); Chain (1); Compositional bias (1); Domain (5); Erroneous initiation (1); Helix (24); Modified residue (3); Natural variant (4); Region (1); Sequence conflict (8); Turn (5)
MVP_HUMAN	Q14764	MVP_HUMAN	reviewed	Major vault protein (MVP) (Lung resistance-related protein)	MVP LRP	Homo sapiens (Human)	893	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear pore [GO:0005643]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ribonucleoprotein complex [GO:0030529]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; cell proliferation [GO:0008283]; ERBB signaling pathway [GO:0038127]; mRNA transport [GO:0051028]; negative regulation of protein autophosphorylation [GO:0031953]; negative regulation of protein tyrosine kinase activity [GO:0061099]; negative regulation of signaling [GO:0023057]; protein activation cascade [GO:0072376]; protein transport [GO:0015031]	cell proliferation [GO:0008283]; ERBB signaling pathway [GO:0038127]; mRNA transport [GO:0051028]; negative regulation of protein autophosphorylation [GO:0031953]; negative regulation of protein tyrosine kinase activity [GO:0061099]; negative regulation of signaling [GO:0023057]; protein activation cascade [GO:0072376]; protein transport [GO:0015031]	protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear pore [GO:0005643]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ribonucleoprotein complex [GO:0030529]	GO:0038127; GO:0008283; GO:0005737; GO:0005856; GO:0070062; GO:0051028; GO:0016020; GO:0031953; GO:0061099; GO:0023057; GO:0005643; GO:0005634; GO:0048471; GO:0072376; GO:0019901; GO:0019903; GO:0015031; GO:0030529	SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nuclear pore complex. Note=5% found in the nuclear pore complex. Translocates from the nucleus to the cytoplasm upon EGF treatment.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Nuclear pore complex; Nucleus; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Repeat; Ribonucleoprotein; Translocation; Transport; mRNA transport	Beta strand (8); Chain (1); Helix (1); Initiator methionine (1); Modified residue (2); Natural variant (2); Repeat (9)
HYPK_HUMAN	Q9NX55	HYPK_HUMAN	reviewed	Huntingtin-interacting protein K (Huntingtin yeast partner K)	HYPK C15orf63 HSPC136	Homo sapiens (Human)	129	cytoplasm [GO:0005737]; nucleus [GO:0005634]			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005737; GO:0005634	SUBCELLULAR LOCATION: Nucleus. Cytoplasm.	Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Polymorphism; Reference proteome	Alternative sequence (2); Chain (1); Coiled coil (1); Erroneous initiation (1); Modified residue (1); Natural variant (1); Sequence caution (1)
SF01_HUMAN	Q15637	SF01_HUMAN	reviewed	Splicing factor 1 (Mammalian branch point-binding protein) (BBP) (mBBP) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Zinc finger protein 162)	SF1 ZFM1 ZNF162	Homo sapiens (Human)	639	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribosome [GO:0005840]; spliceosomal complex [GO:0005681]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270]; Leydig cell differentiation [GO:0033327]; male sex determination [GO:0030238]; mRNA 3'-splice site recognition [GO:0000389]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of nucleic acid-templated transcription [GO:1903507]; negative regulation of smooth muscle cell proliferation [GO:0048662]; regulation of steroid biosynthetic process [GO:0050810]; regulation of transcription, DNA-templated [GO:0006355]; spliceosomal complex assembly [GO:0000245]; transcription, DNA-templated [GO:0006351]	Leydig cell differentiation [GO:0033327]; male sex determination [GO:0030238]; mRNA 3'-splice site recognition [GO:0000389]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of nucleic acid-templated transcription [GO:1903507]; negative regulation of smooth muscle cell proliferation [GO:0048662]; regulation of steroid biosynthetic process [GO:0050810]; regulation of transcription, DNA-templated [GO:0006355]; spliceosomal complex assembly [GO:0000245]; transcription, DNA-templated [GO:0006351]	poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribosome [GO:0005840]; spliceosomal complex [GO:0005681]	GO:0033327; GO:0003723; GO:0000389; GO:0000398; GO:0030238; GO:1903507; GO:0048662; GO:0005654; GO:0005634; GO:0044822; GO:0050810; GO:0006355; GO:0005840; GO:0005681; GO:0000245; GO:0003714; GO:0006351; GO:0008270	SUBCELLULAR LOCATION: Nucleus.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; RNA-binding; Reference proteome; Repressor; Spliceosome; Transcription; Transcription regulation; Zinc; Zinc-finger; mRNA processing; mRNA splicing	Alternative sequence (8); Beta strand (6); Chain (1); Compositional bias (1); Domain (1); Erroneous initiation (1); Helix (10); Initiator methionine (1); Modified residue (6); Motif (1); Mutagenesis (15); Natural variant (1); Sequence conflict (9); Turn (3); Zinc finger (1)
ZCHC3_HUMAN	Q9NUD5	ZCHC3_HUMAN	reviewed	Zinc finger CCHC domain-containing protein 3	ZCCHC3 C20orf99	Homo sapiens (Human)	404	poly(A) RNA binding [GO:0044822]; zinc ion binding [GO:0008270]		poly(A) RNA binding [GO:0044822]; zinc ion binding [GO:0008270]		GO:0044822; GO:0008270		Alternative splicing; Complete proteome; Isopeptide bond; Metal-binding; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation; Zinc; Zinc-finger	Alternative sequence (1); Chain (1); Compositional bias (3); Cross-link (1); Modified residue (1); Sequence conflict (2); Zinc finger (3)
K1C23_HUMAN	Q9C075	K1C23_HUMAN	reviewed	Keratin, type I cytoskeletal 23 (Cytokeratin-23) (CK-23) (Keratin-23) (K23)	KRT23	Homo sapiens (Human)	422	intermediate filament [GO:0005882]; structural molecule activity [GO:0005198]		structural molecule activity [GO:0005198]	intermediate filament [GO:0005882]	GO:0005882; GO:0005198		Alternative splicing; Coiled coil; Complete proteome; Intermediate filament; Keratin; Polymorphism; Reference proteome	Alternative sequence (1); Chain (1); Natural variant (2); Region (8); Sequence conflict (4)
SON_HUMAN	P18583	SON_HUMAN	reviewed	Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3)	SON C21orf50 DBP5 KIAA1019 NREBP HSPC310 HSPC312	Homo sapiens (Human)	2426	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; nucleic acid binding [GO:0003676]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; cytokinesis [GO:0000910]; microtubule cytoskeleton organization [GO:0000226]; mRNA processing [GO:0006397]; negative regulation of apoptotic process [GO:0043066]; regulation of cell cycle [GO:0051726]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]	cytokinesis [GO:0000910]; microtubule cytoskeleton organization [GO:0000226]; mRNA processing [GO:0006397]; negative regulation of apoptotic process [GO:0043066]; regulation of cell cycle [GO:0051726]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]	DNA binding [GO:0003677]; nucleic acid binding [GO:0003676]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]	GO:0003677; GO:0003723; GO:0008380; GO:0000910; GO:0006397; GO:0000226; GO:0043066; GO:0016607; GO:0003676; GO:0005654; GO:0044822; GO:0043484; GO:0051726	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:1424986, ECO:0000269|PubMed:21504830}. Note=Colocalizes with the pre-mRNA splicing factor SRSF2.	Acetylation; Alternative splicing; Cell cycle; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Polymorphism; RNA-binding; Reference proteome; Repeat; mRNA processing; mRNA splicing	Alternative sequence (15); Chain (1); Domain (2); Erroneous initiation (1); Frameshift (1); Initiator methionine (1); Modified residue (24); Natural variant (5); Region (8); Repeat (23); Sequence caution (2); Sequence conflict (16)
CSDE1_HUMAN	O75534	CSDE1_HUMAN	reviewed	Cold shock domain-containing protein E1 (N-ras upstream gene protein) (Protein UNR)	CSDE1 D1S155E KIAA0885 NRU UNR	Homo sapiens (Human)	798	CRD-mediated mRNA stability complex [GO:0070937]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; mitochondrial inner membrane [GO:0005743]; plasma membrane [GO:0005886]; DNA binding [GO:0003677]; poly(A) RNA binding [GO:0044822]; male gonad development [GO:0008584]; nuclear-transcribed mRNA catabolic process, no-go decay [GO:0070966]; regulation of transcription, DNA-templated [GO:0006355]	male gonad development [GO:0008584]; nuclear-transcribed mRNA catabolic process, no-go decay [GO:0070966]; regulation of transcription, DNA-templated [GO:0006355]	DNA binding [GO:0003677]; poly(A) RNA binding [GO:0044822]	CRD-mediated mRNA stability complex [GO:0070937]; cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; mitochondrial inner membrane [GO:0005743]; plasma membrane [GO:0005886]	GO:0070937; GO:0003677; GO:0005794; GO:0005737; GO:0008584; GO:0005743; GO:0070966; GO:0005886; GO:0044822; GO:0006355	SUBCELLULAR LOCATION: Cytoplasm.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Phosphoprotein; RNA-binding; Reference proteome; Repeat	Alternative sequence (2); Beta strand (28); Chain (1); Domain (9); Erroneous initiation (2); Helix (1); Modified residue (3); Sequence conflict (8); Turn (7)
PI42A_HUMAN	P48426	PI42A_HUMAN	reviewed	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha)	PIP4K2A PIP5K2 PIP5K2A	Homo sapiens (Human)	406	cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; 1-phosphatidylinositol-5-phosphate 4-kinase activity [GO:0016309]; ATP binding [GO:0005524]; megakaryocyte development [GO:0035855]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphorylation [GO:0046854]; phospholipid metabolic process [GO:0006644]; small molecule metabolic process [GO:0044281]	megakaryocyte development [GO:0035855]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphorylation [GO:0046854]; phospholipid metabolic process [GO:0006644]; small molecule metabolic process [GO:0044281]	1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; 1-phosphatidylinositol-5-phosphate 4-kinase activity [GO:0016309]; ATP binding [GO:0005524]	cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0016308; GO:0016309; GO:0005524; GO:0005829; GO:0035855; GO:0005634; GO:0006661; GO:0046854; GO:0006644; GO:0005886; GO:0044281	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}. Nucleus {ECO:0000269|PubMed:20583997}. Cytoplasm {ECO:0000269|PubMed:20583997}. Note=May translocate from the cytosol to the cell membrane upon activation of tyrosine phosphorylation. May translocate from the inner to the outer segments of the rod photoreceptor cells in response to light (By similarity). Localization to the nucleus is modulated by the interaction with PIP4K2B. {ECO:0000250}.	3D-structure; ATP-binding; Acetylation; Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Direct protein sequencing; Kinase; Membrane; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transferase	Alternative sequence (1); Beta strand (15); Chain (1); Domain (1); Helix (10); Initiator methionine (1); Modified residue (5); Mutagenesis (2); Natural variant (2); Sequence conflict (5); Turn (3)
LARP1_HUMAN	Q6PKG0	LARP1_HUMAN	reviewed	La-related protein 1 (La ribonucleoprotein domain family member 1)	LARP1 KIAA0731 LARP	Homo sapiens (Human)	1096	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; eukaryotic initiation factor 4E binding [GO:0008190]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; poly(A) RNA binding [GO:0044822]; RNA cap binding [GO:0000339]; translation activator activity [GO:0008494]; translation initiation factor binding [GO:0031369]; cell proliferation [GO:0008283]; positive regulation of macroautophagy [GO:0016239]; positive regulation of translation [GO:0045727]; TOR signaling [GO:0031929]; translational initiation [GO:0006413]	cell proliferation [GO:0008283]; positive regulation of macroautophagy [GO:0016239]; positive regulation of translation [GO:0045727]; TOR signaling [GO:0031929]; translational initiation [GO:0006413]	eukaryotic initiation factor 4E binding [GO:0008190]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; poly(A) RNA binding [GO:0044822]; RNA cap binding [GO:0000339]; translation activator activity [GO:0008494]; translation initiation factor binding [GO:0031369]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]	GO:0000339; GO:0031929; GO:0008283; GO:0005737; GO:0008190; GO:0003730; GO:0048027; GO:0016020; GO:0005654; GO:0044822; GO:0016239; GO:0045727; GO:0008494; GO:0031369; GO:0006413	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:24532714}.	Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Phosphoprotein; Protein biosynthesis; RNA-binding; Reference proteome	Alternative sequence (2); Chain (1); Compositional bias (1); Domain (1); Erroneous initiation (1); Initiator methionine (1); Modified residue (29); Sequence caution (1); Sequence conflict (2)
EVL_HUMAN	Q9UI08	EVL_HUMAN	reviewed	Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like)	EVL RNB6	Homo sapiens (Human)	416	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; membrane [GO:0016020]; profilin binding [GO:0005522]; SH3 domain binding [GO:0017124]; actin filament organization [GO:0007015]; actin polymerization or depolymerization [GO:0008154]; axon guidance [GO:0007411]; cell surface receptor signaling pathway [GO:0007166]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of ruffle assembly [GO:1900028]; nervous system development [GO:0007399]; organ morphogenesis [GO:0009887]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of stress fiber assembly [GO:0051496]; protein homotetramerization [GO:0051289]; small GTPase mediated signal transduction [GO:0007264]	actin filament organization [GO:0007015]; actin polymerization or depolymerization [GO:0008154]; axon guidance [GO:0007411]; cell surface receptor signaling pathway [GO:0007166]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of ruffle assembly [GO:1900028]; nervous system development [GO:0007399]; organ morphogenesis [GO:0009887]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of stress fiber assembly [GO:0051496]; protein homotetramerization [GO:0051289]; small GTPase mediated signal transduction [GO:0007264]	profilin binding [GO:0005522]; SH3 domain binding [GO:0017124]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; membrane [GO:0016020]	GO:0017124; GO:0007015; GO:0008154; GO:0007411; GO:0007166; GO:0005737; GO:0005856; GO:0005829; GO:0005925; GO:0030027; GO:0016020; GO:0010633; GO:1900028; GO:0007399; GO:0009887; GO:0030838; GO:0051496; GO:0005522; GO:0051289; GO:0007264	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Note=Targeted to the leading edge of lamellipodia and the dital tip of stress fibers through interaction with a number of proteins. In activated T-cells, localizes to the F-actin collar and the distal tip of microspikes (By similarity). {ECO:0000250}.	Actin-binding; Alternative splicing; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Polymorphism; Reference proteome; SH3-binding	Alternative sequence (3); Chain (1); Compositional bias (1); Domain (1); Modified residue (9); Motif (1); Natural variant (2); Region (4); Sequence conflict (3)
IF4A3_HUMAN	P38919	IF4A3_HUMAN	reviewed	Eukaryotic initiation factor 4A-III (eIF-4A-III) (eIF4A-III) (EC 3.6.4.13) (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Eukaryotic translation initiation factor 4A isoform 3) (Nuclear matrix protein 265) (NMP 265) (hNMP 265) [Cleaved into: Eukaryotic initiation factor 4A-III, N-terminally processed]	EIF4A3 DDX48 KIAA0111	Homo sapiens (Human)	411	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; ATP-dependent RNA helicase activity [GO:0004004]; mRNA binding [GO:0003729]; poly(A) binding [GO:0008143]; poly(A) RNA binding [GO:0044822]; cytokine-mediated signaling pathway [GO:0019221]; embryonic cranial skeleton morphogenesis [GO:0048701]; gene expression [GO:0010467]; mRNA splicing, via spliceosome [GO:0000398]; mRNA transport [GO:0051028]; negative regulation of translation [GO:0017148]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of translation [GO:0045727]; RNA secondary structure unwinding [GO:0010501]; RNA splicing [GO:0008380]; rRNA processing [GO:0006364]	cytokine-mediated signaling pathway [GO:0019221]; embryonic cranial skeleton morphogenesis [GO:0048701]; gene expression [GO:0010467]; mRNA splicing, via spliceosome [GO:0000398]; mRNA transport [GO:0051028]; negative regulation of translation [GO:0017148]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of translation [GO:0045727]; RNA secondary structure unwinding [GO:0010501]; RNA splicing [GO:0008380]; rRNA processing [GO:0006364]	ATP binding [GO:0005524]; ATP-dependent RNA helicase activity [GO:0004004]; mRNA binding [GO:0003729]; poly(A) binding [GO:0008143]; poly(A) RNA binding [GO:0044822]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]	GO:0005524; GO:0004004; GO:0010501; GO:0008380; GO:0071013; GO:0019221; GO:0005737; GO:0005829; GO:0048701; GO:0035145; GO:0010467; GO:0003729; GO:0000398; GO:0051028; GO:0016020; GO:0017148; GO:0016607; GO:0000288; GO:0000184; GO:0000289; GO:0005654; GO:0044822; GO:0008143; GO:0045727; GO:0006364	SUBCELLULAR LOCATION: Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Detected in dendritic layer as well as the nuclear and cytoplasmic (somatic) compartments of neurons. Colocalizes with STAU1 and FMR1 in dendrites (By similarity). {ECO:0000250}.	3D-structure; ATP-binding; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Helicase; Hydrolase; Nonsense-mediated mRNA decay; Nucleotide-binding; Nucleus; Phosphoprotein; RNA-binding; Reference proteome; Spliceosome; Translation regulation; Transport; mRNA processing; mRNA splicing; mRNA transport; rRNA processing	Beta strand (21); Binding site (3); Chain (2); Domain (2); Erroneous initiation (1); Helix (23); Initiator methionine (1); Modified residue (9); Motif (2); Mutagenesis (8); Natural variant (1); Nucleotide binding (2); Sequence conflict (2); Turn (1)
DPP9_HUMAN	Q86TI2	DPP9_HUMAN	reviewed	Dipeptidyl peptidase 9 (DP9) (EC 3.4.14.5) (Dipeptidyl peptidase IV-related protein 2) (DPRP-2) (Dipeptidyl peptidase IX) (DPP IX) (Dipeptidyl peptidase-like protein 9) (DPLP9)	DPP9 DPRP2	Homo sapiens (Human)	863	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]; aminopeptidase activity [GO:0004177]; identical protein binding [GO:0042802]; serine-type peptidase activity [GO:0008236]		aminopeptidase activity [GO:0004177]; identical protein binding [GO:0042802]; serine-type peptidase activity [GO:0008236]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleus [GO:0005634]	GO:0004177; GO:0005737; GO:0005829; GO:0042802; GO:0016020; GO:0005634; GO:0008236	SUBCELLULAR LOCATION: Isoform 1: Cytoplasm, cytosol {ECO:0000269|PubMed:12662155, ECO:0000269|PubMed:15245913}.; SUBCELLULAR LOCATION: Isoform 2: Nucleus {ECO:0000269|PubMed:24562348}.	Acetylation; Alternative splicing; Aminopeptidase; Complete proteome; Cytoplasm; Hydrolase; Nucleus; Protease; Reference proteome; Serine protease	Active site (3); Alternative sequence (2); Chain (1); Erroneous gene model prediction (2); Erroneous initiation (5); Frameshift (1); Initiator methionine (1); Modified residue (1); Sequence caution (2); Sequence conflict (6)
E9PNS3_HUMAN	E9PNS3	E9PNS3_HUMAN	unreviewed	Toll-interacting protein	TOLLIP	Homo sapiens (Human)	80							Complete proteome; Proteomics identification; Reference proteome	
UBP11_HUMAN	P51784	UBP11_HUMAN	reviewed	Ubiquitin carboxyl-terminal hydrolase 11 (EC 3.4.19.12) (Deubiquitinating enzyme 11) (Ubiquitin thioesterase 11) (Ubiquitin-specific-processing protease 11)	USP11 UHX1	Homo sapiens (Human)	963	cytoplasm [GO:0005737]; nucleus [GO:0005634]; cysteine-type endopeptidase activity [GO:0004197]; ubiquitin-specific protease activity [GO:0004843]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; regulation of proteasomal protein catabolic process [GO:0061136]	proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; regulation of proteasomal protein catabolic process [GO:0061136]	cysteine-type endopeptidase activity [GO:0004197]; ubiquitin-specific protease activity [GO:0004843]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0004197; GO:0005737; GO:0005634; GO:0043161; GO:0016579; GO:0061136; GO:0004843	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Predominantly nuclear. Associates with chromatin.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Hydrolase; Nucleus; Phosphoprotein; Protease; Reference proteome; Thiol protease; Ubl conjugation pathway	Active site (2); Beta strand (12); Chain (1); Domain (2); Erroneous gene model prediction (1); Erroneous initiation (2); Frameshift (1); Helix (6); Modified residue (3); Mutagenesis (1); Sequence conflict (8); Turn (3)
THIC_HUMAN	Q9BWD1	THIC_HUMAN	reviewed	Acetyl-CoA acetyltransferase, cytosolic (EC 2.3.1.9) (Acetyl-CoA transferase-like protein) (Cytosolic acetoacetyl-CoA thiolase)	ACAT2 ACTL	Homo sapiens (Human)	397	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; acetyl-CoA C-acetyltransferase activity [GO:0003985]; lipid metabolic process [GO:0006629]	lipid metabolic process [GO:0006629]	acetyl-CoA C-acetyltransferase activity [GO:0003985]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003985; GO:0005737; GO:0070062; GO:0006629; GO:0005730; GO:0005654; GO:0005634	SUBCELLULAR LOCATION: Cytoplasm.	3D-structure; Acetylation; Acyltransferase; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Polymorphism; Reference proteome; Transferase	Active site (3); Alternative sequence (1); Beta strand (12); Chain (1); Helix (18); Modified residue (4); Natural variant (1); Sequence conflict (3); Turn (6)
FABP5_HUMAN	Q01469	FABP5_HUMAN	reviewed	Fatty acid-binding protein, epidermal (Epidermal-type fatty acid-binding protein) (E-FABP) (Fatty acid-binding protein 5) (Psoriasis-associated fatty acid-binding protein homolog) (PA-FABP)	FABP5	Homo sapiens (Human)	135	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; fatty acid binding [GO:0005504]; lipid binding [GO:0008289]; transporter activity [GO:0005215]; epidermis development [GO:0008544]; glucose metabolic process [GO:0006006]; glucose transport [GO:0015758]; lipid metabolic process [GO:0006629]; phosphatidylcholine biosynthetic process [GO:0006656]; response to wounding [GO:0009611]; small molecule metabolic process [GO:0044281]; triglyceride catabolic process [GO:0019433]	epidermis development [GO:0008544]; glucose metabolic process [GO:0006006]; glucose transport [GO:0015758]; lipid metabolic process [GO:0006629]; phosphatidylcholine biosynthetic process [GO:0006656]; response to wounding [GO:0009611]; small molecule metabolic process [GO:0044281]; triglyceride catabolic process [GO:0019433]	fatty acid binding [GO:0005504]; lipid binding [GO:0008289]; transporter activity [GO:0005215]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]	GO:0005737; GO:0005829; GO:0008544; GO:0070062; GO:0005504; GO:0006006; GO:0015758; GO:0008289; GO:0006629; GO:0005654; GO:0006656; GO:0009611; GO:0044281; GO:0005215; GO:0019433	SUBCELLULAR LOCATION: Cytoplasm.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; Lipid-binding; Phosphoprotein; Reference proteome; Transport	Beta strand (11); Binding site (1); Chain (1); Disulfide bond (1); Helix (3); Initiator methionine (1); Modified residue (3); Region (1)
SC23B_HUMAN	Q15437	SC23B_HUMAN	reviewed	Protein transport protein Sec23B (SEC23-related protein B)	SEC23B	Homo sapiens (Human)	767	COPII vesicle coat [GO:0030127]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; zinc ion binding [GO:0008270]; ER to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192]	ER to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; vesicle-mediated transport [GO:0016192]	zinc ion binding [GO:0008270]	COPII vesicle coat [GO:0030127]; endomembrane system [GO:0012505]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]	GO:0030127; GO:0006888; GO:0000139; GO:0012505; GO:0005789; GO:0033116; GO:0043231; GO:0006886; GO:0016020; GO:0048471; GO:0016192; GO:0008270	SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250}.	Acetylation; Complete proteome; Congenital dyserythropoietic anemia; Disease mutation; ER-Golgi transport; Endoplasmic reticulum; Golgi apparatus; Hereditary hemolytic anemia; Membrane; Polymorphism; Protein transport; Reference proteome; Transport	Chain (1); Initiator methionine (1); Modified residue (2); Natural variant (18)
PHP14_HUMAN	Q9NRX4	PHP14_HUMAN	reviewed	14 kDa phosphohistidine phosphatase (EC 3.1.3.-) (Phosphohistidine phosphatase 1) (Protein janus-A homolog)	PHPT1 PHP14 CGI-202 HSPC141	Homo sapiens (Human)	125	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; calcium channel inhibitor activity [GO:0019855]; ion channel binding [GO:0044325]; phosphohistidine phosphatase activity [GO:0008969]; phosphoprotein phosphatase activity [GO:0004721]; negative regulation of ATP citrate synthase activity [GO:2000984]; negative regulation of lyase activity [GO:0051350]; negative regulation of T cell receptor signaling pathway [GO:0050860]; peptidyl-histidine dephosphorylation [GO:0035971]; positive regulation of cell motility [GO:2000147]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; protein dephosphorylation [GO:0006470]; regulation of actin cytoskeleton reorganization [GO:2000249]	negative regulation of ATP citrate synthase activity [GO:2000984]; negative regulation of lyase activity [GO:0051350]; negative regulation of T cell receptor signaling pathway [GO:0050860]; peptidyl-histidine dephosphorylation [GO:0035971]; positive regulation of cell motility [GO:2000147]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; protein dephosphorylation [GO:0006470]; regulation of actin cytoskeleton reorganization [GO:2000249]	calcium channel inhibitor activity [GO:0019855]; ion channel binding [GO:0044325]; phosphohistidine phosphatase activity [GO:0008969]; phosphoprotein phosphatase activity [GO:0004721]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0019855; GO:0005829; GO:0070062; GO:0044325; GO:2000984; GO:0050860; GO:0051350; GO:0035971; GO:0008969; GO:0004721; GO:2000147; GO:0035774; GO:0006470; GO:2000249	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Protein phosphatase; Reference proteome	Active site (1); Alternative sequence (1); Beta strand (6); Binding site (1); Chain (1); Helix (4); Initiator methionine (1); Modified residue (1); Mutagenesis (6); Region (1); Sequence conflict (3); Turn (2)
PSA3_HUMAN	P25788	PSA3_HUMAN	reviewed	Proteasome subunit alpha type-3 (EC 3.4.25.1) (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8)	PSMA3 HC8 PSC8	Homo sapiens (Human)	255	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]; endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298]; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]	GO:0006977; GO:0000082; GO:0031145; GO:0042590; GO:0002479; GO:0002474; GO:0006915; GO:0034641; GO:0005737; GO:0005829; GO:0004175; GO:0070062; GO:0010467; GO:0045087; GO:0000278; GO:0043066; GO:0090090; GO:0051436; GO:0005654; GO:0005634; GO:0090263; GO:0051437; GO:0012501; GO:0010499; GO:0000502; GO:0005839; GO:0019773; GO:0043161; GO:0000209; GO:0042981; GO:0006521; GO:0051439; GO:0044281; GO:0002223; GO:0004298; GO:0016032	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Host-virus interaction; Hydrolase; Nucleus; Phosphoprotein; Protease; Proteasome; Reference proteome; Threonine protease	Alternative sequence (1); Beta strand (10); Chain (1); Helix (7); Initiator methionine (1); Modified residue (6); Sequence conflict (1); Turn (3)
ABHEB_HUMAN	Q96IU4	ABHEB_HUMAN	reviewed	Alpha/beta hydrolase domain-containing protein 14B (Abhydrolase domain-containing protein 14B) (EC 3.-.-.-) (CCG1-interacting factor B)	ABHD14B CIB	Homo sapiens (Human)	210	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleus [GO:0005634]; hydrolase activity [GO:0016787]; metabolic process [GO:0008152]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]	metabolic process [GO:0008152]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]	hydrolase activity [GO:0016787]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0005737; GO:0005829; GO:0070062; GO:0016787; GO:0008152; GO:0005730; GO:0005634; GO:0045944	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Nucleus; Phosphoprotein; Reference proteome	Active site (3); Alternative sequence (1); Beta strand (11); Chain (1); Erroneous initiation (1); Helix (11); Initiator methionine (1); Modified residue (2)
TCPG_HUMAN	P49368	TCPG_HUMAN	reviewed	T-complex protein 1 subunit gamma (TCP-1-gamma) (CCT-gamma) (hTRiC5)	CCT3 CCTG TRIC5	Homo sapiens (Human)	545	cell body [GO:0044297]; chaperonin-containing T-complex [GO:0005832]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]; plasma membrane [GO:0005886]; zona pellucida receptor complex [GO:0002199]; ATP binding [GO:0005524]; poly(A) RNA binding [GO:0044822]; unfolded protein binding [GO:0051082]; 'de novo' posttranslational protein folding [GO:0051084]; binding of sperm to zona pellucida [GO:0007339]; cellular protein metabolic process [GO:0044267]; pore complex assembly [GO:0046931]; protein folding [GO:0006457]; toxin transport [GO:1901998]	'de novo' posttranslational protein folding [GO:0051084]; binding of sperm to zona pellucida [GO:0007339]; cellular protein metabolic process [GO:0044267]; pore complex assembly [GO:0046931]; protein folding [GO:0006457]; toxin transport [GO:1901998]	ATP binding [GO:0005524]; poly(A) RNA binding [GO:0044822]; unfolded protein binding [GO:0051082]	cell body [GO:0044297]; chaperonin-containing T-complex [GO:0005832]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]; plasma membrane [GO:0005886]; zona pellucida receptor complex [GO:0002199]	GO:0051084; GO:0005524; GO:0007339; GO:0044297; GO:0044267; GO:0005832; GO:0005737; GO:0005856; GO:0005829; GO:0070062; GO:0005874; GO:0005886; GO:0044822; GO:0046931; GO:0006457; GO:1901998; GO:0051082; GO:0002199	SUBCELLULAR LOCATION: Cytoplasm.	ATP-binding; Acetylation; Alternative splicing; Chaperone; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome	Alternative sequence (1); Chain (1); Disulfide bond (1); Erroneous initiation (1); Modified residue (4); Natural variant (1); Sequence conflict (2)
F5H124_HUMAN	F5H124	F5H124_HUMAN	unreviewed	Protein mago nashi homolog 2	MAGOHB	Homo sapiens (Human)	81	catalytic step 2 spliceosome [GO:0071013]; exon-exon junction complex [GO:0035145]; RNA splicing [GO:0008380]	RNA splicing [GO:0008380]		catalytic step 2 spliceosome [GO:0071013]; exon-exon junction complex [GO:0035145]	GO:0008380; GO:0071013; GO:0035145		Complete proteome; Proteomics identification; Reference proteome	
TCPQ_HUMAN	P50990	TCPQ_HUMAN	reviewed	T-complex protein 1 subunit theta (TCP-1-theta) (CCT-theta) (Renal carcinoma antigen NY-REN-15)	CCT8 C21orf112 CCTQ KIAA0002	Homo sapiens (Human)	548	aggresome [GO:0016235]; cell body [GO:0044297]; centrosome [GO:0005813]; chaperonin-containing T-complex [GO:0005832]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament cytoskeleton [GO:0045111]; microtubule [GO:0005874]; zona pellucida receptor complex [GO:0002199]; ATP binding [GO:0005524]; ATPase activity, coupled [GO:0042623]; 'de novo' posttranslational protein folding [GO:0051084]; binding of sperm to zona pellucida [GO:0007339]; cellular protein metabolic process [GO:0044267]; pore complex assembly [GO:0046931]; protein folding [GO:0006457]; toxin transport [GO:1901998]	'de novo' posttranslational protein folding [GO:0051084]; binding of sperm to zona pellucida [GO:0007339]; cellular protein metabolic process [GO:0044267]; pore complex assembly [GO:0046931]; protein folding [GO:0006457]; toxin transport [GO:1901998]	ATPase activity, coupled [GO:0042623]; ATP binding [GO:0005524]	aggresome [GO:0016235]; cell body [GO:0044297]; centrosome [GO:0005813]; chaperonin-containing T-complex [GO:0005832]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intermediate filament cytoskeleton [GO:0045111]; microtubule [GO:0005874]; zona pellucida receptor complex [GO:0002199]	GO:0051084; GO:0005524; GO:0042623; GO:0016235; GO:0007339; GO:0044297; GO:0044267; GO:0005813; GO:0005832; GO:0005737; GO:0005829; GO:0070062; GO:0045111; GO:0005874; GO:0046931; GO:0006457; GO:1901998; GO:0002199	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20080638}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20080638}.	ATP-binding; Acetylation; Alternative splicing; Chaperone; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Isopeptide bond; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation	Alternative sequence (2); Chain (1); Cross-link (2); Erroneous initiation (1); Initiator methionine (1); Modified residue (7); Natural variant (2); Sequence conflict (3)
ROA0_HUMAN	Q13151	ROA0_HUMAN	reviewed	Heterogeneous nuclear ribonucleoprotein A0 (hnRNP A0)	HNRNPA0 HNRPA0	Homo sapiens (Human)	305	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]; AU-rich element binding [GO:0017091]; nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; 3'-UTR-mediated mRNA stabilization [GO:0070935]; gene expression [GO:0010467]; inflammatory response [GO:0006954]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; response to lipopolysaccharide [GO:0032496]; RNA splicing [GO:0008380]	3'-UTR-mediated mRNA stabilization [GO:0070935]; gene expression [GO:0010467]; inflammatory response [GO:0006954]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; response to lipopolysaccharide [GO:0032496]; RNA splicing [GO:0008380]	AU-rich element binding [GO:0017091]; nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]	GO:0070935; GO:0017091; GO:0003723; GO:0008380; GO:0010467; GO:0006954; GO:0006397; GO:0000398; GO:0005654; GO:0000166; GO:0005634; GO:0044822; GO:0019901; GO:0032496; GO:0030529	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Component of ribonucleosomes. {ECO:0000250}.	Acetylation; Complete proteome; Direct protein sequencing; Methylation; Nucleus; Phosphoprotein; RNA-binding; Reference proteome; Repeat; Ribonucleoprotein	Chain (1); Compositional bias (1); Domain (2); Modified residue (6)
NIT2_HUMAN	Q9NQR4	NIT2_HUMAN	reviewed	Omega-amidase NIT2 (EC 3.5.1.3) (Nitrilase homolog 2)	NIT2 CUA002	Homo sapiens (Human)	276	centrosome [GO:0005813]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; omega-amidase activity [GO:0050152]; asparagine metabolic process [GO:0006528]; glutamine metabolic process [GO:0006541]; oxaloacetate metabolic process [GO:0006107]	asparagine metabolic process [GO:0006528]; glutamine metabolic process [GO:0006541]; oxaloacetate metabolic process [GO:0006107]	omega-amidase activity [GO:0050152]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]	GO:0006528; GO:0005813; GO:0005737; GO:0070062; GO:0006541; GO:0005739; GO:0050152; GO:0006107	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17488281}.	Acetylation; Complete proteome; Cytoplasm; Hydrolase; Phosphoprotein; Polymorphism; Reference proteome	Active site (3); Chain (1); Domain (1); Mass spectrometry (1); Modified residue (5); Natural variant (1)
GLMN_HUMAN	Q92990	GLMN_HUMAN	reviewed	Glomulin (FK506-binding protein-associated protein) (FAP) (FKBP-associated protein)	GLMN FAP48 FAP68 VMGLOM	Homo sapiens (Human)	594	Cul2-RING ubiquitin ligase complex [GO:0031462]; Cul3-RING ubiquitin ligase complex [GO:0031463]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; cullin-RING ubiquitin ligase complex [GO:0031461]; intracellular [GO:0005622]; hepatocyte growth factor receptor binding [GO:0005171]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase inhibitor activity [GO:0055105]; muscle cell differentiation [GO:0042692]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of T cell proliferation [GO:0042130]; neural tube closure [GO:0001843]; positive regulation of cytokine secretion [GO:0050715]; positive regulation of interleukin-2 biosynthetic process [GO:0045086]; positive regulation of phosphorylation [GO:0042327]; regulation of gene expression, epigenetic [GO:0040029]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; vasculogenesis [GO:0001570]	muscle cell differentiation [GO:0042692]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of T cell proliferation [GO:0042130]; neural tube closure [GO:0001843]; positive regulation of cytokine secretion [GO:0050715]; positive regulation of interleukin-2 biosynthetic process [GO:0045086]; positive regulation of phosphorylation [GO:0042327]; regulation of gene expression, epigenetic [GO:0040029]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; vasculogenesis [GO:0001570]	hepatocyte growth factor receptor binding [GO:0005171]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase inhibitor activity [GO:0055105]	Cul2-RING ubiquitin ligase complex [GO:0031462]; Cul3-RING ubiquitin ligase complex [GO:0031463]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; cullin-RING ubiquitin ligase complex [GO:0031461]; intracellular [GO:0005622]	GO:0031462; GO:0031463; GO:0031464; GO:0031461; GO:0005171; GO:0005622; GO:0042692; GO:0042130; GO:0031397; GO:0001843; GO:0050715; GO:0045086; GO:0042327; GO:0040029; GO:0032434; GO:0031625; GO:0055105; GO:0001570		3D-structure; Acetylation; Alternative splicing; Coiled coil; Complete proteome; Disease mutation; Phosphoprotein; Polymorphism; Reference proteome	Alternative sequence (2); Beta strand (3); Chain (1); Coiled coil (2); Compositional bias (2); Helix (32); Initiator methionine (1); Modified residue (1); Mutagenesis (1); Natural variant (2); Turn (5)
GTF2I_HUMAN	P78347	GTF2I_HUMAN	reviewed	General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein)	GTF2I BAP135 WBSCR6	Homo sapiens (Human)	998	cell projection [GO:0042995]; cytosol [GO:0005829]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; sequence-specific DNA binding transcription factor activity [GO:0003700]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; signal transduction [GO:0007165]; transcription from RNA polymerase II promoter [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]; transition between slow and fast fiber [GO:0014886]	negative regulation of angiogenesis [GO:0016525]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; signal transduction [GO:0007165]; transcription from RNA polymerase II promoter [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]; transition between slow and fast fiber [GO:0014886]	DNA binding [GO:0003677]; sequence-specific DNA binding transcription factor activity [GO:0003700]	cell projection [GO:0042995]; cytosol [GO:0005829]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003677; GO:0042995; GO:0005829; GO:0016020; GO:0016525; GO:0051481; GO:0043025; GO:0005654; GO:0005634; GO:0003700; GO:0007165; GO:0006366; GO:0006367; GO:0014886	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10373551}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00484, ECO:0000269|PubMed:10373551}. Note=Colocalizes with BTK in the cytoplasm.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; DNA-binding; Direct protein sequencing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Ubl conjugation; Williams-Beuren syndrome	Alternative sequence (4); Beta strand (8); Chain (1); Compositional bias (1); Helix (13); Initiator methionine (1); Modified residue (17); Motif (1); Mutagenesis (4); Natural variant (1); Repeat (6); Sequence conflict (5); Turn (11)
SYG_HUMAN	P41250	SYG_HUMAN	reviewed	Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (AP-4-A synthetase) (Glycyl-tRNA synthetase) (GlyRS)	GARS	Homo sapiens (Human)	739	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; nucleoplasm [GO:0005654]; secretory granule [GO:0030141]; ATP binding [GO:0005524]; glycine-tRNA ligase activity [GO:0004820]; protein dimerization activity [GO:0046983]; diadenosine tetraphosphate biosynthetic process [GO:0015966]; gene expression [GO:0010467]; glycyl-tRNA aminoacylation [GO:0006426]; tRNA aminoacylation for protein translation [GO:0006418]	diadenosine tetraphosphate biosynthetic process [GO:0015966]; gene expression [GO:0010467]; glycyl-tRNA aminoacylation [GO:0006426]; tRNA aminoacylation for protein translation [GO:0006418]	ATP binding [GO:0005524]; glycine-tRNA ligase activity [GO:0004820]; protein dimerization activity [GO:0046983]	axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; nucleoplasm [GO:0005654]; secretory granule [GO:0030141]	GO:0005524; GO:0030424; GO:0005737; GO:0005829; GO:0015966; GO:0070062; GO:0010467; GO:0004820; GO:0006426; GO:0005759; GO:0005654; GO:0046983; GO:0030141; GO:0006418	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9524218}. Mitochondrion {ECO:0000269|PubMed:9524218}. Cell projection, axon {ECO:0000269|PubMed:17035524, ECO:0000269|PubMed:25168514}. Note=Associated with granules in cultured neuron cells. {ECO:0000269|PubMed:17035524}.	3D-structure; ATP-binding; Acetylation; Aminoacyl-tRNA synthetase; Cell projection; Charcot-Marie-Tooth disease; Complete proteome; Cytoplasm; Disease mutation; Ligase; Mitochondrion; Neurodegeneration; Neuropathy; Nucleotide-binding; Phosphoprotein; Protein biosynthesis; Reference proteome	Beta strand (37); Binding site (3); Chain (1); Domain (1); Erroneous initiation (2); Helix (29); Modified residue (3); Natural variant (16); Nucleotide binding (4); Region (2); Sequence conflict (4); Turn (8)
WASH7_HUMAN	Q2M389	WASH7_HUMAN	reviewed	WASH complex subunit 7 (Strumpellin and WASH-interacting protein) (SWIP)	KIAA1033	Homo sapiens (Human)	1173	early endosome [GO:0005769]; endosome [GO:0005768]; nucleoplasm [GO:0005654]; WASH complex [GO:0071203]; endosomal transport [GO:0016197]; endosome organization [GO:0007032]; protein transport [GO:0015031]	endosomal transport [GO:0016197]; endosome organization [GO:0007032]; protein transport [GO:0015031]		early endosome [GO:0005769]; endosome [GO:0005768]; nucleoplasm [GO:0005654]; WASH complex [GO:0071203]	GO:0071203; GO:0005769; GO:0016197; GO:0005768; GO:0007032; GO:0005654; GO:0015031	SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:23676666}.	Acetylation; Alternative splicing; Coiled coil; Complete proteome; Disease mutation; Endosome; Mental retardation; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport	Alternative sequence (2); Chain (1); Coiled coil (1); Erroneous initiation (1); Initiator methionine (1); Modified residue (2); Natural variant (4); Region (1); Sequence caution (1); Sequence conflict (3)
SYAC_HUMAN	P49588	SYAC_HUMAN	reviewed	Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) (Renal carcinoma antigen NY-REN-42)	AARS	Homo sapiens (Human)	968	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; alanine-tRNA ligase activity [GO:0004813]; amino acid binding [GO:0016597]; aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270]; alanyl-tRNA aminoacylation [GO:0006419]; cerebellar Purkinje cell layer development [GO:0021680]; endoplasmic reticulum unfolded protein response [GO:0030968]; gene expression [GO:0010467]; hair follicle development [GO:0001942]; negative regulation of neuron apoptotic process [GO:0043524]; neuromuscular process controlling balance [GO:0050885]; protein folding [GO:0006457]; response to amino acid [GO:0043200]; tRNA aminoacylation for protein translation [GO:0006418]; tRNA modification [GO:0006400]; tRNA processing [GO:0008033]	alanyl-tRNA aminoacylation [GO:0006419]; cerebellar Purkinje cell layer development [GO:0021680]; endoplasmic reticulum unfolded protein response [GO:0030968]; gene expression [GO:0010467]; hair follicle development [GO:0001942]; negative regulation of neuron apoptotic process [GO:0043524]; neuromuscular process controlling balance [GO:0050885]; protein folding [GO:0006457]; response to amino acid [GO:0043200]; tRNA aminoacylation for protein translation [GO:0006418]; tRNA modification [GO:0006400]; tRNA processing [GO:0008033]	alanine-tRNA ligase activity [GO:0004813]; amino acid binding [GO:0016597]; aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; tRNA binding [GO:0000049]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]	GO:0005524; GO:0004813; GO:0006419; GO:0016597; GO:0002161; GO:0021680; GO:0005737; GO:0005829; GO:0030968; GO:0070062; GO:0010467; GO:0001942; GO:0016020; GO:0043524; GO:0050885; GO:0006457; GO:0043200; GO:0006418; GO:0000049; GO:0006400; GO:0008033; GO:0008270	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03133}.	ATP-binding; Acetylation; Alternative splicing; Aminoacyl-tRNA synthetase; Charcot-Marie-Tooth disease; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Ligase; Metal-binding; Neurodegeneration; Neuropathy; Nucleotide-binding; Phosphoprotein; Polymorphism; Protein biosynthesis; RNA-binding; Reference proteome; Ubl conjugation; Zinc; tRNA-binding	Alternative sequence (2); Chain (1); Metal binding (4); Modified residue (5); Natural variant (4); Sequence conflict (4)
PSA1_HUMAN	P25786	PSA1_HUMAN	reviewed	Proteasome subunit alpha type-1 (EC 3.4.25.1) (30 kDa prosomal protein) (PROS-30) (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain)	PSMA1 HC2 NU PROS30 PSC2	Homo sapiens (Human)	263	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; polysome [GO:0005844]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]; endopeptidase activity [GO:0004175]; RNA binding [GO:0003723]; threonine-type endopeptidase activity [GO:0004298]; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	endopeptidase activity [GO:0004175]; RNA binding [GO:0003723]; threonine-type endopeptidase activity [GO:0004298]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; polysome [GO:0005844]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]	GO:0006977; GO:0000082; GO:0003723; GO:0031145; GO:0042590; GO:0002479; GO:0002474; GO:0006915; GO:0034641; GO:0005813; GO:0005737; GO:0005829; GO:0004175; GO:0070062; GO:0010467; GO:0045087; GO:0000278; GO:0043066; GO:0090090; GO:0051436; GO:0005654; GO:0005634; GO:0005844; GO:0090263; GO:0051437; GO:0012501; GO:0010499; GO:0000502; GO:0005839; GO:0019773; GO:0043161; GO:0000209; GO:0042981; GO:0006521; GO:0051439; GO:0044281; GO:0002223; GO:0004298; GO:0016032	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Glycoprotein; Hydrolase; Immunity; Isopeptide bond; Nucleus; Polymorphism; Protease; Proteasome; Reference proteome; Threonine protease; Ubl conjugation	Alternative sequence (1); Beta strand (10); Chain (1); Cross-link (2); Glycosylation (1); Helix (8); Modified residue (1); Natural variant (1); Sequence conflict (1); Turn (1)
MARE1_HUMAN	Q15691	MARE1_HUMAN	reviewed	Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1)	MAPRE1	Homo sapiens (Human)	268	cell projection membrane [GO:0031253]; centrosome [GO:0005813]; cortical microtubule cytoskeleton [GO:0030981]; cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; microtubule plus-end [GO:0035371]; microtubule plus-end binding [GO:0051010]; poly(A) RNA binding [GO:0044822]; protein C-terminus binding [GO:0008022]; cell division [GO:0051301]; cell proliferation [GO:0008283]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; negative regulation of microtubule polymerization [GO:0031115]; organelle organization [GO:0006996]; positive regulation of microtubule plus-end binding [GO:1903033]; protein localization to microtubule [GO:0035372]; small GTPase mediated signal transduction [GO:0007264]	cell division [GO:0051301]; cell proliferation [GO:0008283]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; negative regulation of microtubule polymerization [GO:0031115]; organelle organization [GO:0006996]; positive regulation of microtubule plus-end binding [GO:1903033]; protein localization to microtubule [GO:0035372]; small GTPase mediated signal transduction [GO:0007264]	microtubule plus-end binding [GO:0051010]; poly(A) RNA binding [GO:0044822]; protein C-terminus binding [GO:0008022]	cell projection membrane [GO:0031253]; centrosome [GO:0005813]; cortical microtubule cytoskeleton [GO:0030981]; cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; microtubule plus-end [GO:0035371]	GO:0000086; GO:0005794; GO:0051301; GO:0031253; GO:0008283; GO:0005813; GO:0030981; GO:0005737; GO:0005881; GO:0005829; GO:0005874; GO:0035371; GO:0051010; GO:0000278; GO:0007067; GO:0031115; GO:0006996; GO:0044822; GO:1903033; GO:0008022; GO:0035372; GO:0007264	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associated with the microtubule network at the growing distal tip of microtubules. Also enriched at the centrosome.	3D-structure; Acetylation; Cell cycle; Cell division; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Microtubule; Mitosis; Phosphoprotein; Reference proteome	Chain (1); Domain (2); Helix (11); Initiator methionine (1); Modified residue (2); Mutagenesis (2); Region (4); Turn (2)
TS101_HUMAN	Q99816	TS101_HUMAN	reviewed	Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101)	TSG101	Homo sapiens (Human)	390	cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; multivesicular body [GO:0005771]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; calcium-dependent protein binding [GO:0048306]; DNA binding [GO:0003677]; protein homodimerization activity [GO:0042803]; transcription corepressor activity [GO:0003714]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; virion binding [GO:0046790]; cell cycle arrest [GO:0007050]; cell division [GO:0051301]; cellular protein modification process [GO:0006464]; endosomal transport [GO:0016197]; intracellular transport of virus [GO:0075733]; keratinocyte differentiation [GO:0030216]; membrane organization [GO:0061024]; negative regulation of cell proliferation [GO:0008285]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of viral budding via host ESCRT complex [GO:1903774]; positive regulation of viral process [GO:0048524]; positive regulation of viral release from host cell [GO:1902188]; protein transport [GO:0015031]; regulation of cell growth [GO:0001558]; regulation of extracellular exosome assembly [GO:1903551]; regulation of MAP kinase activity [GO:0043405]; regulation of viral budding via host ESCRT complex [GO:1903772]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding [GO:0046755]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral protein processing [GO:0019082]; virion assembly [GO:0019068]	cell cycle arrest [GO:0007050]; cell division [GO:0051301]; cellular protein modification process [GO:0006464]; endosomal transport [GO:0016197]; intracellular transport of virus [GO:0075733]; keratinocyte differentiation [GO:0030216]; membrane organization [GO:0061024]; negative regulation of cell proliferation [GO:0008285]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of viral budding via host ESCRT complex [GO:1903774]; positive regulation of viral process [GO:0048524]; positive regulation of viral release from host cell [GO:1902188]; protein transport [GO:0015031]; regulation of cell growth [GO:0001558]; regulation of extracellular exosome assembly [GO:1903551]; regulation of MAP kinase activity [GO:0043405]; regulation of viral budding via host ESCRT complex [GO:1903772]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding [GO:0046755]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral protein processing [GO:0019082]; virion assembly [GO:0019068]	calcium-dependent protein binding [GO:0048306]; DNA binding [GO:0003677]; protein homodimerization activity [GO:0042803]; transcription corepressor activity [GO:0003714]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; virion binding [GO:0046790]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; multivesicular body [GO:0005771]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]	GO:0003677; GO:0000813; GO:0048306; GO:0007050; GO:0051301; GO:0006464; GO:0005737; GO:0005769; GO:0016197; GO:0005768; GO:0010008; GO:0070062; GO:0075733; GO:0030216; GO:0005770; GO:0031902; GO:0061024; GO:0005771; GO:0008285; GO:0045892; GO:0005730; GO:0005886; GO:1903543; GO:1903774; GO:0048524; GO:1902188; GO:0042803; GO:0015031; GO:0043405; GO:0001558; GO:1903551; GO:1903772; GO:0003714; GO:0043130; GO:0031625; GO:0043162; GO:0046755; GO:0019058; GO:0016032; GO:0019082; GO:0019068; GO:0046790	SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Late endosome membrane; Peripheral membrane protein. Note=Mainly cytoplasmic. Membrane-associated when active and soluble when inactive. Depending on the stage of the cell cycle, detected in the nucleus. Colocalized with CEP55 in the midbody during cytokinesis.	3D-structure; Acetylation; Alternative splicing; Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm; Endosome; Growth regulation; Host-virus interaction; Membrane; Nucleus; Polymorphism; Protein transport; Reference proteome; Transport; Ubl conjugation	Alternative sequence (1); Beta strand (8); Chain (1); Coiled coil (1); Domain (2); Helix (5); Initiator methionine (1); Modified residue (1); Motif (1); Mutagenesis (11); Natural variant (1); Region (1); Sequence conflict (1); Turn (4)
MBNL1_HUMAN	Q9NR56	MBNL1_HUMAN	reviewed	Muscleblind-like protein 1 (Triplet-expansion RNA-binding protein)	MBNL1 EXP KIAA0428 MBNL	Homo sapiens (Human)	388	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; alternative mRNA splicing, via spliceosome [GO:0000380]; embryonic limb morphogenesis [GO:0030326]; in utero embryonic development [GO:0001701]; mRNA splice site selection [GO:0006376]; myoblast differentiation [GO:0045445]; nervous system development [GO:0007399]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]; skeletal muscle tissue development [GO:0007519]	alternative mRNA splicing, via spliceosome [GO:0000380]; embryonic limb morphogenesis [GO:0030326]; in utero embryonic development [GO:0001701]; mRNA splice site selection [GO:0006376]; myoblast differentiation [GO:0045445]; nervous system development [GO:0007399]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]; skeletal muscle tissue development [GO:0007519]	double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003723; GO:0008380; GO:0000380; GO:0005813; GO:0005737; GO:0010494; GO:0003725; GO:0030326; GO:0001701; GO:0006376; GO:0046872; GO:0045445; GO:0007399; GO:0005654; GO:0005634; GO:0044822; GO:0043484; GO:0000381; GO:0007519	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cytoplasmic granule. Note=Localized with DDX1, TIAL1 and YBX1 in stress granules upon stress. Localized in the cytoplasm of multinucleated myotubes. Colocalizes with nuclear foci of retained expanded-repeat transcripts in myotubes from patients affected by myotonic dystrophy.	3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Metal-binding; Nucleus; RNA-binding; Reference proteome; Repeat; Zinc; Zinc-finger; mRNA processing; mRNA splicing	Alternative sequence (5); Beta strand (7); Chain (1); Erroneous initiation (1); Helix (7); Sequence conflict (1); Turn (3); Zinc finger (4)
RD23A_HUMAN	P54725	RD23A_HUMAN	reviewed	UV excision repair protein RAD23 homolog A (HR23A) (hHR23A)	RAD23A	Homo sapiens (Human)	363	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; proteasome complex [GO:0000502]; damaged DNA binding [GO:0003684]; polyubiquitin binding [GO:0031593]; single-stranded DNA binding [GO:0003697]; ubiquitin-specific protease binding [GO:1990381]; nucleotide-excision repair [GO:0006289]; positive regulation of viral genome replication [GO:0045070]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; viral process [GO:0016032]	nucleotide-excision repair [GO:0006289]; positive regulation of viral genome replication [GO:0045070]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; viral process [GO:0016032]	damaged DNA binding [GO:0003684]; polyubiquitin binding [GO:0031593]; single-stranded DNA binding [GO:0003697]; ubiquitin-specific protease binding [GO:1990381]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; proteasome complex [GO:0000502]	GO:0005737; GO:0003684; GO:0005654; GO:0006289; GO:0031593; GO:0045070; GO:0000502; GO:0043161; GO:0032434; GO:0003697; GO:1990381; GO:0016032	SUBCELLULAR LOCATION: Nucleus.	3D-structure; Alternative splicing; Complete proteome; DNA damage; DNA repair; Host-virus interaction; Isopeptide bond; Nucleus; Phosphoprotein; Polymorphism; Proteasome; Reference proteome; Repeat; Ubl conjugation	Alternative sequence (2); Beta strand (12); Chain (1); Cross-link (1); Domain (3); Erroneous initiation (1); Frameshift (1); Helix (13); Modified residue (5); Mutagenesis (14); Natural variant (3); Region (1); Turn (8)
SP16H_HUMAN	Q9Y5B9	SP16H_HUMAN	reviewed	FACT complex subunit SPT16 (Chromatin-specific transcription elongation factor 140 kDa subunit) (FACT 140 kDa subunit) (FACTp140) (Facilitates chromatin transcription complex subunit SPT16) (hSPT16)	SUPT16H FACT140 FACTP140	Homo sapiens (Human)	1047	chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; poly(A) RNA binding [GO:0044822]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; gene expression [GO:0010467]; nucleosome disassembly [GO:0006337]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of viral transcription [GO:0050434]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]; viral process [GO:0016032]	DNA repair [GO:0006281]; DNA replication [GO:0006260]; gene expression [GO:0010467]; nucleosome disassembly [GO:0006337]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of viral transcription [GO:0050434]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]; viral process [GO:0016032]	poly(A) RNA binding [GO:0044822]	chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0006281; GO:0006260; GO:0005694; GO:0010467; GO:0005654; GO:0006337; GO:0005634; GO:0044822; GO:0032786; GO:0050434; GO:0006368; GO:0006366; GO:0016032	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10421373}. Chromosome {ECO:0000269|PubMed:10421373}. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci.	ADP-ribosylation; Acetylation; Chromosome; Coiled coil; Complete proteome; DNA damage; DNA repair; DNA replication; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation	Chain (1); Coiled coil (1); Compositional bias (1); Initiator methionine (1); Modified residue (16); Sequence caution (2)
HNRPU_HUMAN	Q00839	HNRPU_HUMAN	reviewed	Heterogeneous nuclear ribonucleoprotein U (hnRNP U) (Scaffold attachment factor A) (SAF-A) (p120) (pp120)	HNRNPU HNRPU SAFA U21.1	Homo sapiens (Human)	825	catalytic step 2 spliceosome [GO:0071013]; cell surface [GO:0009986]; CRD-mediated mRNA stability complex [GO:0070937]; cytoplasmic ribonucleoprotein granule [GO:0036464]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]; ATP binding [GO:0005524]; core promoter binding [GO:0001047]; DNA binding [GO:0003677]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; circadian regulation of gene expression [GO:0032922]; CRD-mediated mRNA stabilization [GO:0070934]; gene expression [GO:0010467]; mRNA splicing, via spliceosome [GO:0000398]; osteoblast differentiation [GO:0001649]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]	circadian regulation of gene expression [GO:0032922]; CRD-mediated mRNA stabilization [GO:0070934]; gene expression [GO:0010467]; mRNA splicing, via spliceosome [GO:0000398]; osteoblast differentiation [GO:0001649]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]	ATP binding [GO:0005524]; core promoter binding [GO:0001047]; DNA binding [GO:0003677]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; cell surface [GO:0009986]; CRD-mediated mRNA stability complex [GO:0070937]; cytoplasmic ribonucleoprotein granule [GO:0036464]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]	GO:0005524; GO:0070937; GO:0070934; GO:0003677; GO:0003723; GO:0006396; GO:0008380; GO:0071013; GO:0009986; GO:0032922; GO:0001047; GO:0036464; GO:0010467; GO:0000398; GO:0016020; GO:0005654; GO:0005634; GO:0001649; GO:0044822; GO:0030529	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20858735}. Cytoplasm {ECO:0000269|PubMed:19029303}. Cell surface {ECO:0000269|PubMed:7993898}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. {ECO:0000269|PubMed:17289661}.	3D-structure; ATP-binding; Acetylation; Alternative splicing; Biological rhythms; Citrullination; Complete proteome; Cytoplasm; DNA-binding; Direct protein sequencing; Methylation; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; RNA-binding; Reference proteome; Ribonucleoprotein; Spliceosome; mRNA processing; mRNA splicing	Alternative sequence (1); Chain (1); Compositional bias (5); Domain (2); Initiator methionine (1); Modified residue (20); Natural variant (1); Nucleotide binding (1); Region (1); Sequence caution (1); Sequence conflict (1); Turn (1)
CF211_HUMAN	Q9H993	ARMT1_HUMAN	reviewed	Protein-glutamate O-methyltransferase (EC 2.1.1.-) (Acidic residue methyltransferase 1)	ARMT1 C6orf211	Homo sapiens (Human)	441	enzyme binding [GO:0019899]; protein carboxyl O-methyltransferase activity [GO:0051998]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; cellular response to DNA damage stimulus [GO:0006974]; methylation [GO:0032259]; protein methylation [GO:0006479]; regulation of response to DNA damage stimulus [GO:2001020]	cellular response to DNA damage stimulus [GO:0006974]; methylation [GO:0032259]; protein methylation [GO:0006479]; regulation of response to DNA damage stimulus [GO:2001020]	enzyme binding [GO:0019899]; protein carboxyl O-methyltransferase activity [GO:0051998]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]		GO:0008757; GO:0006974; GO:0019899; GO:0032259; GO:0051998; GO:0006479; GO:2001020		Acetylation; Complete proteome; DNA damage; Methylation; Methyltransferase; Phosphoprotein; Polymorphism; Reference proteome; S-adenosyl-L-methionine; Transferase	Binding site (2); Chain (1); Initiator methionine (1); Modified residue (3); Natural variant (7); Sequence conflict (4)
F5H039_HUMAN	F5H039	F5H039_HUMAN	unreviewed	Gephyrin	GPHN	Homo sapiens (Human)	782	cytoplasm [GO:0005737]; molybdopterin adenylyltransferase activity [GO:0061598]; molybdopterin molybdotransferase activity [GO:0061599]; glycine receptor clustering [GO:0072579]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777]; molybdenum incorporation into molybdenum-molybdopterin complex [GO:0018315]	glycine receptor clustering [GO:0072579]; molybdenum incorporation into molybdenum-molybdopterin complex [GO:0018315]; Mo-molybdopterin cofactor biosynthetic process [GO:0006777]	molybdopterin adenylyltransferase activity [GO:0061598]; molybdopterin molybdotransferase activity [GO:0061599]	cytoplasm [GO:0005737]	GO:0006777; GO:0005737; GO:0072579; GO:0018315; GO:0061598; GO:0061599		Complete proteome; Proteomics identification; Reference proteome	
ARC1B_HUMAN	O15143	ARC1B_HUMAN	reviewed	Actin-related protein 2/3 complex subunit 1B (Arp2/3 complex 41 kDa subunit) (p41-ARC)	ARPC1B ARC41	Homo sapiens (Human)	372	actin cytoskeleton [GO:0015629]; Arp2/3 protein complex [GO:0005885]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; structural constituent of cytoskeleton [GO:0005200]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; movement of cell or subcellular component [GO:0006928]	Arp2/3 complex-mediated actin nucleation [GO:0034314]; movement of cell or subcellular component [GO:0006928]	structural constituent of cytoskeleton [GO:0005200]	actin cytoskeleton [GO:0015629]; Arp2/3 protein complex [GO:0005885]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]	GO:0034314; GO:0005885; GO:0015629; GO:0005737; GO:0070062; GO:0005925; GO:0006928; GO:0005200	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.	Acetylation; Actin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Polymorphism; Reference proteome; Repeat; WD repeat	Chain (1); Initiator methionine (1); Modified residue (1); Natural variant (1); Repeat (6)
PCNA_HUMAN	P12004	PCNA_HUMAN	reviewed	Proliferating cell nuclear antigen (PCNA) (Cyclin)	PCNA	Homo sapiens (Human)	261	centrosome [GO:0005813]; cytoplasm [GO:0005737]; DNA replication factor C complex [GO:0005663]; extracellular exosome [GO:0070062]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PCNA complex [GO:0043626]; PCNA-p21 complex [GO:0070557]; chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; dinucleotide insertion or deletion binding [GO:0032139]; DNA polymerase binding [GO:0070182]; DNA polymerase processivity factor activity [GO:0030337]; histone acetyltransferase binding [GO:0035035]; identical protein binding [GO:0042802]; MutLalpha complex binding [GO:0032405]; purine-specific mismatch base pair DNA N-glycosylase activity [GO:0000701]; receptor tyrosine kinase binding [GO:0030971]; base-excision repair [GO:0006284]; cell proliferation [GO:0008283]; cellular response to UV [GO:0034644]; DNA damage response, detection of DNA damage [GO:0042769]; DNA repair [GO:0006281]; DNA strand elongation involved in DNA replication [GO:0006271]; epithelial cell differentiation [GO:0030855]; error-free translesion synthesis [GO:0070987]; error-prone translesion synthesis [GO:0042276]; G1/S transition of mitotic cell cycle [GO:0000082]; heart development [GO:0007507]; leading strand elongation [GO:0006272]; mismatch repair [GO:0006298]; mitotic cell cycle [GO:0000278]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair, DNA gap filling [GO:0006297]; positive regulation of deoxyribonuclease activity [GO:0032077]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA replication [GO:0045740]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]; response to cadmium ion [GO:0046686]; response to lipid [GO:0033993]; telomere maintenance [GO:0000723]; telomere maintenance via recombination [GO:0000722]; telomere maintenance via semi-conservative replication [GO:0032201]; transcription-coupled nucleotide-excision repair [GO:0006283]; translesion synthesis [GO:0019985]	base-excision repair [GO:0006284]; cell proliferation [GO:0008283]; cellular response to UV [GO:0034644]; DNA damage response, detection of DNA damage [GO:0042769]; DNA repair [GO:0006281]; DNA strand elongation involved in DNA replication [GO:0006271]; epithelial cell differentiation [GO:0030855]; error-free translesion synthesis [GO:0070987]; error-prone translesion synthesis [GO:0042276]; G1/S transition of mitotic cell cycle [GO:0000082]; heart development [GO:0007507]; leading strand elongation [GO:0006272]; mismatch repair [GO:0006298]; mitotic cell cycle [GO:0000278]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair, DNA gap filling [GO:0006297]; positive regulation of deoxyribonuclease activity [GO:0032077]; positive regulation of DNA repair [GO:0045739]; positive regulation of DNA replication [GO:0045740]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]; response to cadmium ion [GO:0046686]; response to lipid [GO:0033993]; telomere maintenance [GO:0000723]; telomere maintenance via recombination [GO:0000722]; telomere maintenance via semi-conservative replication [GO:0032201]; transcription-coupled nucleotide-excision repair [GO:0006283]; translesion synthesis [GO:0019985]	chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; dinucleotide insertion or deletion binding [GO:0032139]; DNA polymerase binding [GO:0070182]; DNA polymerase processivity factor activity [GO:0030337]; histone acetyltransferase binding [GO:0035035]; identical protein binding [GO:0042802]; MutLalpha complex binding [GO:0032405]; purine-specific mismatch base pair DNA N-glycosylase activity [GO:0000701]; receptor tyrosine kinase binding [GO:0030971]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; DNA replication factor C complex [GO:0005663]; extracellular exosome [GO:0070062]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PCNA complex [GO:0043626]; PCNA-p21 complex [GO:0070557]	GO:0042769; GO:0070182; GO:0030337; GO:0006281; GO:0005663; GO:0006271; GO:0000082; GO:0032405; GO:0043626; GO:0070557; GO:0006284; GO:0008283; GO:0034644; GO:0005813; GO:0003682; GO:0005737; GO:0003684; GO:0032139; GO:0030855; GO:0070987; GO:0042276; GO:0070062; GO:0007507; GO:0035035; GO:0042802; GO:0006272; GO:0006298; GO:0000278; GO:0043596; GO:0005654; GO:0006289; GO:0006297; GO:0005634; GO:0045739; GO:0045740; GO:0032077; GO:0000701; GO:0030971; GO:0000083; GO:0046686; GO:0033993; GO:0000723; GO:0000722; GO:0032201; GO:0006283; GO:0019985	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24115439, ECO:0000269|PubMed:24939902}. Note=Colocalizes with CREBBP, EP300 and POLD1 to sites of DNA damage (PubMed:24939902). Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase. Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents. {ECO:0000269|PubMed:24939902}.	3D-structure; Acetylation; Complete proteome; DNA damage; DNA repair; DNA replication; DNA-binding; Deafness; Direct protein sequencing; Disease mutation; Dwarfism; Isopeptide bond; Methylation; Neurodegeneration; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation	Beta strand (22); Chain (1); Cross-link (1); DNA binding (1); Helix (6); Modified residue (5); Mutagenesis (9); Natural variant (1); Region (1); Turn (2)
PGK1_HUMAN	P00558	PGK1_HUMAN	reviewed	Phosphoglycerate kinase 1 (EC 2.7.2.3) (Cell migration-inducing gene 10 protein) (Primer recognition protein 2) (PRP 2)	PGK1 PGKA MIG10 OK/SW-cl.110	Homo sapiens (Human)	417	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; membrane raft [GO:0045121]; ATP binding [GO:0005524]; phosphoglycerate kinase activity [GO:0004618]; canonical glycolysis [GO:0061621]; carbohydrate metabolic process [GO:0005975]; epithelial cell differentiation [GO:0030855]; gluconeogenesis [GO:0006094]; glucose metabolic process [GO:0006006]; phosphorylation [GO:0016310]; small molecule metabolic process [GO:0044281]	canonical glycolysis [GO:0061621]; carbohydrate metabolic process [GO:0005975]; epithelial cell differentiation [GO:0030855]; gluconeogenesis [GO:0006094]; glucose metabolic process [GO:0006006]; phosphorylation [GO:0016310]; small molecule metabolic process [GO:0044281]	ATP binding [GO:0005524]; phosphoglycerate kinase activity [GO:0004618]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; membrane raft [GO:0045121]	GO:0005524; GO:0061621; GO:0005975; GO:0005829; GO:0030855; GO:0070062; GO:0006094; GO:0006006; GO:0016020; GO:0045121; GO:0004618; GO:0016310; GO:0044281	SUBCELLULAR LOCATION: Cytoplasm.	3D-structure; ATP-binding; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Glycolysis; Hereditary hemolytic anemia; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Transferase	Alternative sequence (1); Beta strand (22); Binding site (6); Chain (1); Helix (23); Initiator methionine (1); Modified residue (20); Natural variant (12); Nucleotide binding (1); Region (2); Sequence conflict (2); Turn (3)
THUM3_HUMAN	Q9BV44	THUM3_HUMAN	reviewed	THUMP domain-containing protein 3	THUMPD3	Homo sapiens (Human)	507	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; methyltransferase activity [GO:0008168]; RNA binding [GO:0003723]		methyltransferase activity [GO:0008168]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]	GO:0003723; GO:0005737; GO:0008168; GO:0005730		Complete proteome; Methyltransferase; Polymorphism; RNA-binding; Reference proteome; Transferase	Chain (1); Compositional bias (1); Domain (1); Natural variant (1); Sequence conflict (1)
ZAP70_HUMAN	P43403	ZAP70_HUMAN	reviewed	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase)	ZAP70 SRK	Homo sapiens (Human)	619	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]; receptor binding [GO:0005102]; adaptive immune response [GO:0002250]; B cell activation [GO:0042113]; beta selection [GO:0043366]; cell differentiation [GO:0030154]; immune response [GO:0006955]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; negative thymic T cell selection [GO:0045060]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of alpha-beta T cell proliferation [GO:0046641]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of T cell differentiation [GO:0045582]; positive thymic T cell selection [GO:0045059]; protein phosphorylation [GO:0006468]; T cell activation [GO:0042110]; T cell aggregation [GO:0070489]; T cell differentiation [GO:0030217]; T cell migration [GO:0072678]; T cell receptor signaling pathway [GO:0050852]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	adaptive immune response [GO:0002250]; B cell activation [GO:0042113]; beta selection [GO:0043366]; cell differentiation [GO:0030154]; immune response [GO:0006955]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; negative thymic T cell selection [GO:0045060]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of alpha-beta T cell proliferation [GO:0046641]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of T cell differentiation [GO:0045582]; positive thymic T cell selection [GO:0045059]; protein phosphorylation [GO:0006468]; T cell activation [GO:0042110]; T cell aggregation [GO:0070489]; T cell differentiation [GO:0030217]; T cell migration [GO:0072678]; T cell receptor signaling pathway [GO:0050852]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]	ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]; receptor binding [GO:0005102]	cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]	GO:0005524; GO:0042113; GO:0042110; GO:0070489; GO:0030217; GO:0072678; GO:0042101; GO:0050852; GO:0002250; GO:0043366; GO:0030154; GO:0005911; GO:0005737; GO:0005829; GO:0031234; GO:0006955; GO:0001772; GO:0045087; GO:0035556; GO:0045060; GO:0004715; GO:0038083; GO:0018108; GO:0005886; GO:0045582; GO:0046638; GO:0046641; GO:0050850; GO:0045059; GO:0006468; GO:0004713; GO:0005102; GO:0007169	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9813084}. Cell membrane {ECO:0000269|PubMed:9813084}; Peripheral membrane protein {ECO:0000269|PubMed:9813084}. Note=In quiescent T-lymphocytes, it is cytoplasmic. Upon TCR activation, it is recruited at the plasma membrane by interacting with CD247/CD3Z. Colocalizes together with RHOH in the immunological synapse. RHOH is required for its proper localization to the cell membrane and cytoskeleton fractions in the thymocytes (By similarity). {ECO:0000250}.	3D-structure; ATP-binding; Acetylation; Adaptive immunity; Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Disease mutation; Immunity; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; SCID; SH2 domain; Transferase; Tyrosine-protein kinase	Active site (1); Alternative sequence (3); Beta strand (21); Binding site (1); Chain (1); Domain (3); Helix (21); Modified residue (8); Mutagenesis (18); Natural variant (11); Nucleotide binding (1); Region (2); Turn (6)
NUDT5_HUMAN	Q9UKK9	NUDT5_HUMAN	reviewed	ADP-sugar pyrophosphatase (EC 3.6.1.13) (8-oxo-dGDP phosphatase) (EC 3.6.1.58) (Nucleoside diphosphate-linked moiety X motif 5) (Nudix motif 5) (YSA1H)	NUDT5 HSPC115	Homo sapiens (Human)	219	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular [GO:0005622]; nucleus [GO:0005634]; ADP-ribose diphosphatase activity [GO:0047631]; ADP-sugar diphosphatase activity [GO:0019144]; magnesium ion binding [GO:0000287]; nucleoside-diphosphatase activity [GO:0017110]; snoRNA binding [GO:0030515]; D-ribose catabolic process [GO:0019303]; nucleobase-containing small molecule catabolic process [GO:0034656]; nucleobase-containing small molecule metabolic process [GO:0055086]; nucleotide metabolic process [GO:0009117]; ribonucleoside diphosphate catabolic process [GO:0009191]; small molecule metabolic process [GO:0044281]	D-ribose catabolic process [GO:0019303]; nucleobase-containing small molecule catabolic process [GO:0034656]; nucleobase-containing small molecule metabolic process [GO:0055086]; nucleotide metabolic process [GO:0009117]; ribonucleoside diphosphate catabolic process [GO:0009191]; small molecule metabolic process [GO:0044281]	ADP-ribose diphosphatase activity [GO:0047631]; ADP-sugar diphosphatase activity [GO:0019144]; magnesium ion binding [GO:0000287]; nucleoside-diphosphatase activity [GO:0017110]; snoRNA binding [GO:0030515]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular [GO:0005622]; nucleus [GO:0005634]	GO:0047631; GO:0019144; GO:0019303; GO:0005829; GO:0070062; GO:0005622; GO:0000287; GO:0034656; GO:0055086; GO:0017110; GO:0009117; GO:0005634; GO:0009191; GO:0044281; GO:0030515		3D-structure; Acetylation; Complete proteome; Hydrolase; Magnesium; Metal-binding; Phosphoprotein; Polymorphism; RNA-binding; Reference proteome	Beta strand (13); Binding site (5); Chain (1); Domain (1); Helix (7); Metal binding (6); Modified residue (6); Motif (1); Mutagenesis (8); Natural variant (1); Region (1); Sequence conflict (1); Turn (2)
PSMG2_HUMAN	Q969U7	PSMG2_HUMAN	reviewed	Proteasome assembly chaperone 2 (PAC-2) (Hepatocellular carcinoma-susceptibility protein 3) (Tumor necrosis factor superfamily member 5-induced protein 1)	PSMG2 HCCA3 PAC2 TNFSF5IP1	Homo sapiens (Human)	264	nucleus [GO:0005634]; mitotic spindle assembly checkpoint [GO:0007094]; negative regulation of apoptotic process [GO:0043066]; proteasome assembly [GO:0043248]	mitotic spindle assembly checkpoint [GO:0007094]; negative regulation of apoptotic process [GO:0043066]; proteasome assembly [GO:0043248]		nucleus [GO:0005634]	GO:0007094; GO:0043066; GO:0005634; GO:0043248	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9EST4}.	Alternative splicing; Chaperone; Complete proteome; Nucleus; Reference proteome	Alternative sequence (1); Chain (1); Erroneous initiation (1); Sequence conflict (2)
V9GZ55_HUMAN	V9GZ55	V9GZ55_HUMAN	unreviewed	Proteasome assembly chaperone 2 (Fragment)	PSMG2	Homo sapiens (Human)	209							Complete proteome; Proteomics identification; Reference proteome	Non-terminal residue (1)
RS8_HUMAN	P62241	RS8_HUMAN	reviewed	40S ribosomal protein S8	RPS8 OK/SW-cl.83	Homo sapiens (Human)	208	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]; poly(A) RNA binding [GO:0044822]; structural constituent of ribosome [GO:0003735]; cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	poly(A) RNA binding [GO:0044822]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]	GO:0006614; GO:0044267; GO:0005737; GO:0005829; GO:0022627; GO:0070062; GO:0005925; GO:0010467; GO:0000462; GO:0016020; GO:0000184; GO:0005634; GO:0044822; GO:0030529; GO:0003735; GO:0006412; GO:0006414; GO:0006413; GO:0006415; GO:0019058; GO:0016032; GO:0019083	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Polymorphism; Reference proteome; Ribonucleoprotein; Ribosomal protein	Chain (1); Initiator methionine (1); Modified residue (2); Natural variant (1)
DPYL2_HUMAN	Q16555	DPYL2_HUMAN	reviewed	Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3) (Unc-33-like phosphoprotein 2) (ULIP-2)	DPYSL2 CRMP2 ULIP2	Homo sapiens (Human)	572	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; growth cone [GO:0030426]; membrane [GO:0016020]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; protein complex [GO:0043234]; terminal bouton [GO:0043195]; dihydropyrimidinase activity [GO:0004157]; axon guidance [GO:0007411]; cytoskeleton organization [GO:0007010]; endocytosis [GO:0006897]; nervous system development [GO:0007399]; nucleobase-containing compound metabolic process [GO:0006139]; olfactory bulb development [GO:0021772]; positive regulation of glutamate secretion [GO:0014049]; regulation of axon extension [GO:0030516]; response to amphetamine [GO:0001975]; response to cocaine [GO:0042220]; response to drug [GO:0042493]; signal transduction [GO:0007165]; spinal cord development [GO:0021510]; synaptic vesicle transport [GO:0048489]	axon guidance [GO:0007411]; cytoskeleton organization [GO:0007010]; endocytosis [GO:0006897]; nervous system development [GO:0007399]; nucleobase-containing compound metabolic process [GO:0006139]; olfactory bulb development [GO:0021772]; positive regulation of glutamate secretion [GO:0014049]; regulation of axon extension [GO:0030516]; response to amphetamine [GO:0001975]; response to cocaine [GO:0042220]; response to drug [GO:0042493]; signal transduction [GO:0007165]; spinal cord development [GO:0021510]; synaptic vesicle transport [GO:0048489]	dihydropyrimidinase activity [GO:0004157]	cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; growth cone [GO:0030426]; membrane [GO:0016020]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; protein complex [GO:0043234]; terminal bouton [GO:0043195]	GO:0007411; GO:0005856; GO:0007010; GO:0005829; GO:0030425; GO:0004157; GO:0006897; GO:0070062; GO:0030426; GO:0016020; GO:0005739; GO:0007399; GO:0043025; GO:0006139; GO:0021772; GO:0014049; GO:0043234; GO:0030516; GO:0001975; GO:0042220; GO:0042493; GO:0007165; GO:0021510; GO:0048489; GO:0043195	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:20801876}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20801876}. Membrane {ECO:0000269|PubMed:20801876}. Note=Tightly but non-covalently associated with membranes.	3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Differentiation; Direct protein sequencing; Membrane; Neurogenesis; Phosphoprotein; Polymorphism; Reference proteome; S-nitrosylation	Alternative sequence (1); Beta strand (17); Chain (1); Helix (19); Modified residue (15); Mutagenesis (9); Natural variant (2); Turn (7)
ANM3_HUMAN	O60678	ANM3_HUMAN	reviewed	Protein arginine N-methyltransferase 3 (EC 2.1.1.-) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3)	PRMT3 HRMT1L3	Homo sapiens (Human)	531	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ribosome [GO:0005840]; histone-arginine N-methyltransferase activity [GO:0008469]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; modified amino acid binding [GO:0072341]; protein-arginine N-methyltransferase activity [GO:0016274]; protein-arginine omega-N asymmetric methyltransferase activity [GO:0035242]; histone arginine methylation [GO:0034969]; negative regulation of protein ubiquitination [GO:0031397]; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine [GO:0019919]; regulation of transcription, DNA-templated [GO:0006355]	histone arginine methylation [GO:0034969]; negative regulation of protein ubiquitination [GO:0031397]; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine [GO:0019919]; regulation of transcription, DNA-templated [GO:0006355]	histone-arginine N-methyltransferase activity [GO:0008469]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; modified amino acid binding [GO:0072341]; protein-arginine N-methyltransferase activity [GO:0016274]; protein-arginine omega-N asymmetric methyltransferase activity [GO:0035242]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ribosome [GO:0005840]	GO:0005737; GO:0005829; GO:0034969; GO:0008469; GO:0046872; GO:0008168; GO:0072341; GO:0031397; GO:0019919; GO:0016274; GO:0035242; GO:0006355; GO:0005840	SUBCELLULAR LOCATION: Cytoplasm.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Metal-binding; Methyltransferase; Phosphoprotein; Polymorphism; Reference proteome; S-adenosyl-L-methionine; Transferase; Zinc; Zinc-finger	Active site (2); Alternative sequence (1); Beta strand (16); Binding site (5); Chain (1); Domain (1); Helix (13); Initiator methionine (1); Modified residue (3); Mutagenesis (3); Natural variant (3); Sequence conflict (3); Site (1); Turn (5); Zinc finger (1)
RL12_HUMAN	P30050	RL12_HUMAN	reviewed	60S ribosomal protein L12	RPL12	Homo sapiens (Human)	165	cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; poly(A) RNA binding [GO:0044822]; structural constituent of ribosome [GO:0003735]; cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	poly(A) RNA binding [GO:0044822]; structural constituent of ribosome [GO:0003735]	cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]	GO:0006614; GO:0044267; GO:0005829; GO:0022625; GO:0070062; GO:0005925; GO:0010467; GO:0016020; GO:0000184; GO:0044822; GO:0003735; GO:0006412; GO:0006414; GO:0006413; GO:0006415; GO:0019058; GO:0016032; GO:0019083		3D-structure; Acetylation; Alternative splicing; Complete proteome; Phosphoprotein; RNA-binding; Reference proteome; Ribonucleoprotein; Ribosomal protein	Alternative sequence (1); Chain (1); Modified residue (4)
HS74L_HUMAN	O95757	HS74L_HUMAN	reviewed	Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Osmotic stress protein 94)	HSPA4L APG1 OSP94	Homo sapiens (Human)	839	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ATP binding [GO:0005524]; protein folding [GO:0006457]; response to unfolded protein [GO:0006986]	protein folding [GO:0006457]; response to unfolded protein [GO:0006986]	ATP binding [GO:0005524]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0005524; GO:0005737; GO:0005829; GO:0005634; GO:0006457; GO:0006986	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=May translocate to the nucleus after heat shock. {ECO:0000250}.	ATP-binding; Acetylation; Chaperone; Complete proteome; Cytoplasm; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Stress response	Chain (1); Initiator methionine (1); Modified residue (8); Natural variant (3); Sequence conflict (1)
PAPS1_HUMAN	O43252	PAPS1_HUMAN	reviewed	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPS synthase 1) (PAPSS 1) (Sulfurylase kinase 1) (SK 1) (SK1) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)]	PAPSS1 ATPSK1 PAPSS	Homo sapiens (Human)	624	cytosol [GO:0005829]; adenylylsulfate kinase activity [GO:0004020]; ATP binding [GO:0005524]; nucleotidyltransferase activity [GO:0016779]; sulfate adenylyltransferase (ATP) activity [GO:0004781]; 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process [GO:0050428]; 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; carbohydrate metabolic process [GO:0005975]; glycosaminoglycan metabolic process [GO:0030203]; skeletal system development [GO:0001501]; small molecule metabolic process [GO:0044281]; sulfate assimilation [GO:0000103]; xenobiotic metabolic process [GO:0006805]	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process [GO:0050428]; 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; carbohydrate metabolic process [GO:0005975]; glycosaminoglycan metabolic process [GO:0030203]; skeletal system development [GO:0001501]; small molecule metabolic process [GO:0044281]; sulfate assimilation [GO:0000103]; xenobiotic metabolic process [GO:0006805]	adenylylsulfate kinase activity [GO:0004020]; ATP binding [GO:0005524]; nucleotidyltransferase activity [GO:0016779]; sulfate adenylyltransferase (ATP) activity [GO:0004781]	cytosol [GO:0005829]	GO:0050428; GO:0050427; GO:0005524; GO:0004020; GO:0005975; GO:0005829; GO:0030203; GO:0016779; GO:0001501; GO:0044281; GO:0004781; GO:0000103; GO:0006805		3D-structure; ATP-binding; Acetylation; Complete proteome; Kinase; Multifunctional enzyme; Nucleotide-binding; Nucleotidyltransferase; Polymorphism; Reference proteome; Transferase	Active site (1); Beta strand (21); Chain (1); Helix (25); Modified residue (2); Motif (1); Mutagenesis (5); Natural variant (2); Nucleotide binding (1); Region (2); Sequence conflict (3); Turn (6)
SRSF5_HUMAN	Q13243	SRSF5_HUMAN	reviewed	Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5)	SRSF5 HRS SFRS5 SRP40	Homo sapiens (Human)	272	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; gene expression [GO:0010467]; mRNA 3'-end processing [GO:0031124]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; mRNA splice site selection [GO:0006376]; mRNA splicing, via spliceosome [GO:0000398]; regulation of cell cycle [GO:0051726]; response to wounding [GO:0009611]; RNA splicing [GO:0008380]; termination of RNA polymerase II transcription [GO:0006369]; transcription from RNA polymerase II promoter [GO:0006366]	gene expression [GO:0010467]; mRNA 3'-end processing [GO:0031124]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; mRNA splice site selection [GO:0006376]; mRNA splicing, via spliceosome [GO:0000398]; regulation of cell cycle [GO:0051726]; response to wounding [GO:0009611]; RNA splicing [GO:0008380]; termination of RNA polymerase II transcription [GO:0006369]; transcription from RNA polymerase II promoter [GO:0006366]	nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0008380; GO:0005737; GO:0010467; GO:0031124; GO:0006406; GO:0006397; GO:0006376; GO:0000398; GO:0016607; GO:0005730; GO:0005654; GO:0000166; GO:0005634; GO:0044822; GO:0051726; GO:0009611; GO:0006369; GO:0006366	SUBCELLULAR LOCATION: Nucleus.	Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein; Polymorphism; RNA-binding; Reference proteome; Repeat; mRNA processing; mRNA splicing	Alternative sequence (3); Chain (1); Compositional bias (2); Domain (2); Frameshift (1); Modified residue (6); Natural variant (1)
NUCKS_HUMAN	Q9H1E3	NUCKS_HUMAN	reviewed	Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (P1)	NUCKS1 NUCKS JC7	Homo sapiens (Human)	243	cytoplasm [GO:0005737]; nucleus [GO:0005634]; poly(A) RNA binding [GO:0044822]		poly(A) RNA binding [GO:0044822]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005737; GO:0005634; GO:0044822	SUBCELLULAR LOCATION: Nucleus.	Alternative splicing; Complete proteome; Nucleus; Phosphoprotein; Polymorphism; Reference proteome	Alternative sequence (1); Chain (1); Compositional bias (2); Erroneous gene model prediction (1); Erroneous termination (1); Modified residue (21); Natural variant (2); Sequence conflict (1)
SRSF1_HUMAN	Q07955	SRSF1_HUMAN	reviewed	Serine/arginine-rich splicing factor 1 (Alternative-splicing factor 1) (ASF-1) (Splicing factor, arginine/serine-rich 1) (pre-mRNA-splicing factor SF2, P33 subunit)	SRSF1 ASF SF2 SF2P33 SFRS1 OK/SW-cl.3	Homo sapiens (Human)	248	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; mRNA binding [GO:0003729]; nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; cardiac muscle contraction [GO:0060048]; gene expression [GO:0010467]; in utero embryonic development [GO:0001701]; mRNA 3'-end processing [GO:0031124]; mRNA 5'-splice site recognition [GO:0000395]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; mRNA splice site selection [GO:0006376]; mRNA splicing, via spliceosome [GO:0000398]; regulation of mRNA splicing, via spliceosome [GO:0048024]; regulation of mRNA stability [GO:0043488]; regulation of transcription, DNA-templated [GO:0006355]; regulation of translation [GO:0006417]; RNA splicing [GO:0008380]; termination of RNA polymerase II transcription [GO:0006369]; transcription from RNA polymerase II promoter [GO:0006366]	cardiac muscle contraction [GO:0060048]; gene expression [GO:0010467]; in utero embryonic development [GO:0001701]; mRNA 3'-end processing [GO:0031124]; mRNA 5'-splice site recognition [GO:0000395]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; mRNA splice site selection [GO:0006376]; mRNA splicing, via spliceosome [GO:0000398]; regulation of mRNA splicing, via spliceosome [GO:0048024]; regulation of mRNA stability [GO:0043488]; regulation of transcription, DNA-templated [GO:0006355]; regulation of translation [GO:0006417]; RNA splicing [GO:0008380]; termination of RNA polymerase II transcription [GO:0006369]; transcription from RNA polymerase II promoter [GO:0006366]	mRNA binding [GO:0003729]; nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003723; GO:0008380; GO:0060048; GO:0071013; GO:0005737; GO:0070062; GO:0010467; GO:0001701; GO:0031124; GO:0000395; GO:0003729; GO:0006406; GO:0006397; GO:0006376; GO:0000398; GO:0016607; GO:0005654; GO:0000166; GO:0005634; GO:0044822; GO:0048024; GO:0043488; GO:0006355; GO:0006417; GO:0006369; GO:0006366	SUBCELLULAR LOCATION: Cytoplasm. Nucleus speckle. Note=In nuclear speckles. Shuttles between the nucleus and the cytoplasm.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Methylation; Nucleus; Phosphoprotein; Polymorphism; RNA-binding; Reference proteome; Repeat; Spliceosome; Transport; mRNA processing; mRNA splicing; mRNA transport	Alternative sequence (3); Beta strand (15); Chain (1); Compositional bias (2); Domain (2); Helix (6); Initiator methionine (1); Modified residue (14); Mutagenesis (15); Natural variant (1); Region (1); Turn (1)
AATM_HUMAN	P00505	AATM_HUMAN	reviewed	Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Plasma membrane-associated fatty acid-binding protein) (FABPpm) (Transaminase A)	GOT2	Homo sapiens (Human)	430	extracellular exosome [GO:0070062]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; kynurenine-oxoglutarate transaminase activity [GO:0016212]; L-aspartate:2-oxoglutarate aminotransferase activity [GO:0004069]; L-phenylalanine:2-oxoglutarate aminotransferase activity [GO:0080130]; poly(A) RNA binding [GO:0044822]; pyridoxal phosphate binding [GO:0030170]; 2-oxoglutarate metabolic process [GO:0006103]; 4-hydroxyproline catabolic process [GO:0019470]; aspartate biosynthetic process [GO:0006532]; aspartate catabolic process [GO:0006533]; aspartate metabolic process [GO:0006531]; carbohydrate metabolic process [GO:0005975]; cellular amino acid biosynthetic process [GO:0008652]; cellular nitrogen compound metabolic process [GO:0034641]; fatty acid transport [GO:0015908]; gluconeogenesis [GO:0006094]; glucose metabolic process [GO:0006006]; glutamate catabolic process to 2-oxoglutarate [GO:0019551]; glutamate catabolic process to aspartate [GO:0019550]; glutamate metabolic process [GO:0006536]; oxaloacetate metabolic process [GO:0006107]; response to ethanol [GO:0045471]; small molecule metabolic process [GO:0044281]	2-oxoglutarate metabolic process [GO:0006103]; 4-hydroxyproline catabolic process [GO:0019470]; aspartate biosynthetic process [GO:0006532]; aspartate catabolic process [GO:0006533]; aspartate metabolic process [GO:0006531]; carbohydrate metabolic process [GO:0005975]; cellular amino acid biosynthetic process [GO:0008652]; cellular nitrogen compound metabolic process [GO:0034641]; fatty acid transport [GO:0015908]; gluconeogenesis [GO:0006094]; glucose metabolic process [GO:0006006]; glutamate catabolic process to 2-oxoglutarate [GO:0019551]; glutamate catabolic process to aspartate [GO:0019550]; glutamate metabolic process [GO:0006536]; oxaloacetate metabolic process [GO:0006107]; response to ethanol [GO:0045471]; small molecule metabolic process [GO:0044281]	kynurenine-oxoglutarate transaminase activity [GO:0016212]; L-aspartate:2-oxoglutarate aminotransferase activity [GO:0004069]; L-phenylalanine:2-oxoglutarate aminotransferase activity [GO:0080130]; poly(A) RNA binding [GO:0044822]; pyridoxal phosphate binding [GO:0030170]	extracellular exosome [GO:0070062]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	GO:0006103; GO:0019470; GO:0004069; GO:0080130; GO:0006532; GO:0006533; GO:0006531; GO:0005975; GO:0008652; GO:0034641; GO:0070062; GO:0015908; GO:0006094; GO:0006006; GO:0019551; GO:0019550; GO:0006536; GO:0016212; GO:0005743; GO:0005759; GO:0005739; GO:0006107; GO:0005886; GO:0044822; GO:0030170; GO:0045471; GO:0044281	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:9537447}. Cell membrane {ECO:0000269|PubMed:9537447}. Note=Exposure to alcohol promotes translocation to the cell membrane.	Acetylation; Alternative splicing; Aminotransferase; Cell membrane; Complete proteome; Direct protein sequencing; Lipid transport; Membrane; Mitochondrion; Nitration; Phosphoprotein; Polymorphism; Pyridoxal phosphate; Reference proteome; Transferase; Transit peptide; Transport	Alternative sequence (1); Binding site (4); Chain (1); Modified residue (39); Natural variant (4); Sequence conflict (4); Transit peptide (1)
ANX11_HUMAN	P50995	ANX11_HUMAN	reviewed	Annexin A11 (56 kDa autoantigen) (Annexin XI) (Annexin-11) (Calcyclin-associated annexin 50) (CAP-50)	ANXA11 ANX11	Homo sapiens (Human)	505	azurophil granule [GO:0042582]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; phagocytic vesicle [GO:0045335]; specific granule [GO:0042581]; spindle [GO:0005819]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; MHC class II protein complex binding [GO:0023026]; phosphatidylethanolamine binding [GO:0008429]; poly(A) RNA binding [GO:0044822]; S100 protein binding [GO:0044548]; cell cycle [GO:0007049]; cell division [GO:0051301]; phagocytosis [GO:0006909]; response to calcium ion [GO:0051592]	cell cycle [GO:0007049]; cell division [GO:0051301]; phagocytosis [GO:0006909]; response to calcium ion [GO:0051592]	calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; calcium ion binding [GO:0005509]; MHC class II protein complex binding [GO:0023026]; phosphatidylethanolamine binding [GO:0008429]; poly(A) RNA binding [GO:0044822]; S100 protein binding [GO:0044548]	azurophil granule [GO:0042582]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; phagocytic vesicle [GO:0045335]; specific granule [GO:0042581]; spindle [GO:0005819]	GO:0023026; GO:0044548; GO:0042582; GO:0005509; GO:0005544; GO:0048306; GO:0007049; GO:0051301; GO:0005737; GO:0070062; GO:0042470; GO:0016020; GO:0030496; GO:0005635; GO:0005654; GO:0045335; GO:0006909; GO:0008429; GO:0044822; GO:0051592; GO:0042581; GO:0005819	SUBCELLULAR LOCATION: Cytoplasm. Melanosome. Nucleus envelope. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle. Note=Found throughout the nucleoplasm at interphase and during mitosis concentrates around the mitotic apparatus (By similarity). Elevation of intracellular calcium causes relocalization from the nucleoplasm to the nuclear envelope, with little effect on the cytoplasmic pool. Localization to the nuclear envelope is cell-cycle dependent. {ECO:0000250}.	Acetylation; Alternative splicing; Annexin; Calcium; Calcium/phospholipid-binding; Cell cycle; Cell division; Complete proteome; Cytoplasm; Cytoskeleton; Nucleus; Polymorphism; Reference proteome; Repeat	Alternative sequence (1); Chain (1); Modified residue (3); Natural variant (3); Repeat (4)
PSB3_HUMAN	P49720	PSB3_HUMAN	reviewed	Proteasome subunit beta type-3 (EC 3.4.25.1) (Proteasome chain 13) (Proteasome component C10-II) (Proteasome theta chain)	PSMB3	Homo sapiens (Human)	205	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; threonine-type endopeptidase activity [GO:0004298]; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	threonine-type endopeptidase activity [GO:0004298]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]	GO:0006977; GO:0000082; GO:0005794; GO:0015629; GO:0031145; GO:0042590; GO:0002479; GO:0002474; GO:0006915; GO:0034641; GO:0005737; GO:0005829; GO:0070062; GO:0010467; GO:0045087; GO:0005739; GO:0000278; GO:0043066; GO:0090090; GO:0051436; GO:0005654; GO:0005634; GO:0090263; GO:0051437; GO:0012501; GO:0000502; GO:0005839; GO:0000209; GO:0042981; GO:0006521; GO:0051439; GO:0044281; GO:0002223; GO:0004298; GO:0016032	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Host-virus interaction; Hydrolase; Nucleus; Polymorphism; Protease; Proteasome; Reference proteome; Threonine protease	Beta strand (14); Chain (1); Helix (4); Initiator methionine (1); Modified residue (2); Natural variant (1); Turn (2)
H4_HUMAN	P62805	H4_HUMAN	reviewed	Histone H4	HIST1H4A H4/A H4FA; HIST1H4B H4/I H4FI; HIST1H4C H4/G H4FG; HIST1H4D H4/B H4FB; HIST1H4E H4/J H4FJ; HIST1H4F H4/C H4FC; HIST1H4H H4/H H4FH; HIST1H4I H4/M H4FM; HIST1H4J H4/E H4FE; HIST1H4K H4/D H4FD; HIST1H4L H4/K H4FK; HIST2H4A H4/N H4F2 H4FN HIST2H4; HIST2H4B H4/O H4FO; HIST4H4	Homo sapiens (Human)	103	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; protein complex [GO:0043234]; DNA binding [GO:0003677]; histone binding [GO:0042393]; histone demethylase activity (H4-K20 specific) [GO:0035575]; poly(A) RNA binding [GO:0044822]; CENP-A containing nucleosome assembly [GO:0034080]; chromatin organization [GO:0006325]; chromatin silencing at rDNA [GO:0000183]; DNA methylation on cytosine [GO:0032776]; DNA replication-dependent nucleosome assembly [GO:0006335]; DNA replication-independent nucleosome assembly [GO:0006336]; gene expression [GO:0010467]; histone H4-K20 demethylation [GO:0035574]; mitotic cell cycle [GO:0000278]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of megakaryocyte differentiation [GO:0045653]; nucleosome assembly [GO:0006334]; protein heterotetramerization [GO:0051290]; regulation of gene expression, epigenetic [GO:0040029]; small GTPase mediated signal transduction [GO:0007264]; telomere maintenance [GO:0000723]	CENP-A containing nucleosome assembly [GO:0034080]; chromatin organization [GO:0006325]; chromatin silencing at rDNA [GO:0000183]; DNA methylation on cytosine [GO:0032776]; DNA replication-dependent nucleosome assembly [GO:0006335]; DNA replication-independent nucleosome assembly [GO:0006336]; gene expression [GO:0010467]; histone H4-K20 demethylation [GO:0035574]; mitotic cell cycle [GO:0000278]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of megakaryocyte differentiation [GO:0045653]; nucleosome assembly [GO:0006334]; protein heterotetramerization [GO:0051290]; regulation of gene expression, epigenetic [GO:0040029]; small GTPase mediated signal transduction [GO:0007264]; telomere maintenance [GO:0000723]	DNA binding [GO:0003677]; histone binding [GO:0042393]; histone demethylase activity (H4-K20 specific) [GO:0035575]; poly(A) RNA binding [GO:0044822]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; protein complex [GO:0043234]	GO:0034080; GO:0003677; GO:0032776; GO:0006335; GO:0006336; GO:0006325; GO:0000183; GO:0070062; GO:0005576; GO:0010467; GO:0035574; GO:0042393; GO:0035575; GO:0016020; GO:0000278; GO:0045814; GO:0045653; GO:0000228; GO:0005654; GO:0000786; GO:0006334; GO:0005634; GO:0044822; GO:0043234; GO:0051290; GO:0040029; GO:0007264; GO:0000723	SUBCELLULAR LOCATION: Nucleus. Chromosome.	3D-structure; Acetylation; Chromosomal rearrangement; Chromosome; Citrullination; Complete proteome; DNA-binding; Direct protein sequencing; Isopeptide bond; Methylation; Nucleosome core; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation	Beta strand (6); Chain (1); Cross-link (1); DNA binding (1); Frameshift (1); Helix (3); Initiator methionine (1); Modified residue (23); Natural variant (1); Sequence conflict (2); Turn (1)
SASH3_HUMAN	O75995	SASH3_HUMAN	reviewed	SAM and SH3 domain-containing protein 3 (SH3 protein expressed in lymphocytes homolog)	SASH3 CXorf9 SLY	Homo sapiens (Human)	380	cytoplasm [GO:0005737]; nucleus [GO:0005634]; homeostasis of number of cells within a tissue [GO:0048873]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043372]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interferon-gamma production [GO:0032729]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of organ growth [GO:0046622]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of tumor necrosis factor production [GO:0032760]	homeostasis of number of cells within a tissue [GO:0048873]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043372]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of interferon-gamma production [GO:0032729]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of organ growth [GO:0046622]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of tumor necrosis factor production [GO:0032760]		cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005737; GO:0048873; GO:0005634; GO:0030890; GO:0043372; GO:0002726; GO:0042102; GO:0002639; GO:0032729; GO:0032733; GO:0032743; GO:0032753; GO:0046622; GO:0032760		Complete proteome; Phosphoprotein; Reference proteome; SH3 domain	Chain (1); Domain (2); Modified residue (13); Sequence conflict (2)
ENPL_HUMAN	P14625	ENPL_HUMAN	reviewed	Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Tumor rejection antigen 1) (gp96 homolog)	HSP90B1 GRP94 TRA1	Homo sapiens (Human)	803	cytosol [GO:0005829]; endocytic vesicle lumen [GO:0071682]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; low-density lipoprotein particle receptor binding [GO:0050750]; protein phosphatase binding [GO:0019903]; RNA binding [GO:0003723]; virion binding [GO:0046790]; actin rod assembly [GO:0031247]; ATF6-mediated unfolded protein response [GO:0036500]; cellular protein metabolic process [GO:0044267]; cellular response to ATP [GO:0071318]; endoplasmic reticulum unfolded protein response [GO:0030968]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; innate immune response [GO:0045087]; negative regulation of apoptotic process [GO:0043066]; protein folding in endoplasmic reticulum [GO:0034975]; protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898]; regulation of phosphoprotein phosphatase activity [GO:0043666]; response to endoplasmic reticulum stress [GO:0034976]; response to hypoxia [GO:0001666]; retrograde protein transport, ER to cytosol [GO:0030970]; sequestering of calcium ion [GO:0051208]; toll-like receptor signaling pathway [GO:0002224]	actin rod assembly [GO:0031247]; ATF6-mediated unfolded protein response [GO:0036500]; cellular protein metabolic process [GO:0044267]; cellular response to ATP [GO:0071318]; endoplasmic reticulum unfolded protein response [GO:0030968]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; innate immune response [GO:0045087]; negative regulation of apoptotic process [GO:0043066]; protein folding in endoplasmic reticulum [GO:0034975]; protein transport [GO:0015031]; receptor-mediated endocytosis [GO:0006898]; regulation of phosphoprotein phosphatase activity [GO:0043666]; response to endoplasmic reticulum stress [GO:0034976]; response to hypoxia [GO:0001666]; retrograde protein transport, ER to cytosol [GO:0030970]; sequestering of calcium ion [GO:0051208]; toll-like receptor signaling pathway [GO:0002224]	ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; low-density lipoprotein particle receptor binding [GO:0050750]; protein phosphatase binding [GO:0019903]; RNA binding [GO:0003723]; virion binding [GO:0046790]	cytosol [GO:0005829]; endocytic vesicle lumen [GO:0071682]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]	GO:0036500; GO:0005524; GO:0030433; GO:0003723; GO:0031247; GO:0005509; GO:0044267; GO:0071318; GO:0005829; GO:0071682; GO:0005783; GO:0005788; GO:0005789; GO:0030968; GO:0070062; GO:0031012; GO:0005576; GO:0005925; GO:0045087; GO:0050750; GO:0042470; GO:0016020; GO:0030496; GO:0043066; GO:0005634; GO:0048471; GO:0005886; GO:0034975; GO:0019903; GO:0015031; GO:0006898; GO:0043666; GO:0034976; GO:0001666; GO:0030970; GO:0051208; GO:0002224; GO:0046790	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.	3D-structure; ATP-binding; Acetylation; Calcium; Chaperone; Complete proteome; Direct protein sequencing; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Nucleotide-binding; Phosphoprotein; Reference proteome; Signal	Beta strand (8); Binding site (6); Chain (1); Disulfide bond (1); Glycosylation (6); Helix (8); Modified residue (7); Motif (1); Sequence conflict (3); Signal peptide (1); Turn (3)
GNAI2_HUMAN	P04899	GNAI2_HUMAN	reviewed	Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)	GNAI2 GNAI2B	Homo sapiens (Human)	355	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; heterotrimeric G-protein complex [GO:0005834]; membrane [GO:0016020]; membrane raft [GO:0045121]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; G-protein beta/gamma-subunit complex binding [GO:0031683]; G-protein coupled receptor binding [GO:0001664]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; signal transducer activity [GO:0004871]; activation of MAPKK activity [GO:0000186]; adenosine receptor signaling pathway [GO:0001973]; adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [GO:0007193]; blood coagulation [GO:0007596]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell proliferation [GO:0008283]; G-protein coupled acetylcholine receptor signaling pathway [GO:0007213]; G-protein coupled receptor signaling pathway [GO:0007186]; gamma-aminobutyric acid signaling pathway [GO:0007214]; intracellular signal transduction [GO:0035556]; metabolic process [GO:0008152]; negative regulation of adenylate cyclase activity [GO:0007194]; negative regulation of synaptic transmission [GO:0050805]; platelet activation [GO:0030168]; positive regulation of cell proliferation [GO:0008284]; regulation of calcium ion transport [GO:0051924]; response to nutrient [GO:0007584]; signal transduction [GO:0007165]; synaptic transmission [GO:0007268]	activation of MAPKK activity [GO:0000186]; adenosine receptor signaling pathway [GO:0001973]; adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [GO:0007193]; blood coagulation [GO:0007596]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell proliferation [GO:0008283]; gamma-aminobutyric acid signaling pathway [GO:0007214]; G-protein coupled acetylcholine receptor signaling pathway [GO:0007213]; G-protein coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; metabolic process [GO:0008152]; negative regulation of adenylate cyclase activity [GO:0007194]; negative regulation of synaptic transmission [GO:0050805]; platelet activation [GO:0030168]; positive regulation of cell proliferation [GO:0008284]; regulation of calcium ion transport [GO:0051924]; response to nutrient [GO:0007584]; signal transduction [GO:0007165]; synaptic transmission [GO:0007268]	G-protein beta/gamma-subunit complex binding [GO:0031683]; G-protein coupled receptor binding [GO:0001664]; GTPase activity [GO:0003924]; GTP binding [GO:0005525]; metal ion binding [GO:0046872]; signal transducer activity [GO:0004871]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; heterotrimeric G-protein complex [GO:0005834]; membrane [GO:0016020]; membrane raft [GO:0045121]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	GO:0031683; GO:0007213; GO:0001664; GO:0007186; GO:0005525; GO:0003924; GO:0000186; GO:0001973; GO:0007193; GO:0007596; GO:0007049; GO:0051301; GO:0008283; GO:0005813; GO:0005737; GO:0005829; GO:0070062; GO:1903561; GO:0007214; GO:0005834; GO:0035556; GO:0016020; GO:0045121; GO:0008152; GO:0046872; GO:0030496; GO:0007194; GO:0050805; GO:0005654; GO:0005886; GO:0030168; GO:0008284; GO:0051924; GO:0007584; GO:0004871; GO:0007165; GO:0007268	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17635935}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17635935}. Cell membrane {ECO:0000269|PubMed:17635935}. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody.	ADP-ribosylation; Alternative splicing; Cell cycle; Cell division; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; GTP-binding; Lipoprotein; Magnesium; Membrane; Metal-binding; Myristate; Nucleotide-binding; Palmitate; Reference proteome; Transducer	Alternative sequence (5); Binding site (1); Chain (1); Initiator methionine (1); Lipidation (2); Metal binding (2); Modified residue (2); Nucleotide binding (4)
ODO2_HUMAN	P36957	ODO2_HUMAN	reviewed	Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) (E2K)	DLST DLTS	Homo sapiens (Human)	453	extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; nucleus [GO:0005634]; oxoglutarate dehydrogenase complex [GO:0045252]; dihydrolipoyllysine-residue succinyltransferase activity [GO:0004149]; cellular metabolic process [GO:0044237]; cellular nitrogen compound metabolic process [GO:0034641]; generation of precursor metabolites and energy [GO:0006091]; L-lysine catabolic process to acetyl-CoA via saccharopine [GO:0033512]; lysine catabolic process [GO:0006554]; small molecule metabolic process [GO:0044281]; tricarboxylic acid cycle [GO:0006099]	cellular metabolic process [GO:0044237]; cellular nitrogen compound metabolic process [GO:0034641]; generation of precursor metabolites and energy [GO:0006091]; L-lysine catabolic process to acetyl-CoA via saccharopine [GO:0033512]; lysine catabolic process [GO:0006554]; small molecule metabolic process [GO:0044281]; tricarboxylic acid cycle [GO:0006099]	dihydrolipoyllysine-residue succinyltransferase activity [GO:0004149]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; nucleus [GO:0005634]; oxoglutarate dehydrogenase complex [GO:0045252]	GO:0033512; GO:0044237; GO:0034641; GO:0004149; GO:0070062; GO:0006091; GO:0006554; GO:0016020; GO:0005759; GO:0005634; GO:0045252; GO:0044281; GO:0006099	SUBCELLULAR LOCATION: Mitochondrion.	Acetylation; Acyltransferase; Alternative splicing; Complete proteome; Direct protein sequencing; Lipoyl; Mitochondrion; Polymorphism; Reference proteome; Transferase; Transit peptide; Tricarboxylic acid cycle	Active site (2); Alternative sequence (2); Chain (1); Domain (1); Modified residue (7); Natural variant (2); Sequence conflict (7); Transit peptide (1)
CDC42_HUMAN	P60953	CDC42_HUMAN	reviewed	Cell division control protein 42 homolog (G25K GTP-binding protein)	CDC42	Homo sapiens (Human)	191	apical part of cell [GO:0045177]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; leading edge membrane [GO:0031256]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]; spindle midzone [GO:0051233]; apolipoprotein A-I receptor binding [GO:0034191]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; thioesterase binding [GO:0031996]; actin cytoskeleton organization [GO:0030036]; actin filament branching [GO:0090135]; actin filament bundle assembly [GO:0051017]; adherens junction organization [GO:0034332]; axon guidance [GO:0007411]; blood coagulation [GO:0007596]; canonical Wnt signaling pathway [GO:0060070]; cardiac conduction system development [GO:0003161]; cellular protein localization [GO:0034613]; dendritic cell migration [GO:0036336]; ephrin receptor signaling pathway [GO:0048013]; epidermal growth factor receptor signaling pathway [GO:0007173]; epithelial cell-cell adhesion [GO:0090136]; epithelial-mesenchymal cell signaling [GO:0060684]; establishment of Golgi localization [GO:0051683]; establishment or maintenance of apical/basal cell polarity [GO:0035088]; establishment or maintenance of cell polarity [GO:0007163]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; filopodium assembly [GO:0046847]; Golgi organization [GO:0007030]; hair follicle morphogenesis [GO:0031069]; hair follicle placode formation [GO:0060789]; heart contraction [GO:0060047]; innate immune response [GO:0045087]; keratinization [GO:0031424]; keratinocyte development [GO:0003334]; macrophage differentiation [GO:0030225]; metabolic process [GO:0008152]; multicellular organism growth [GO:0035264]; muscle cell differentiation [GO:0042692]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of gene expression [GO:0010629]; negative regulation of protein complex assembly [GO:0031333]; neuron fate determination [GO:0048664]; nuclear migration [GO:0007097]; organelle transport along microtubule [GO:0072384]; positive regulation of cytokinesis [GO:0032467]; positive regulation of DNA replication [GO:0045740]; positive regulation of gene expression [GO:0010628]; positive regulation of hair follicle cell proliferation [GO:0071338]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of JNK cascade [GO:0046330]; positive regulation of metalloenzyme activity [GO:0048554]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of pseudopodium assembly [GO:0031274]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of synapse structural plasticity [GO:0051835]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of filopodium assembly [GO:0051489]; regulation of mitotic nuclear division [GO:0007088]; regulation of protein catabolic process [GO:0042176]; regulation of protein heterodimerization activity [GO:0043497]; regulation of protein kinase activity [GO:0045859]; regulation of protein stability [GO:0031647]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]; sprouting angiogenesis [GO:0002040]; submandibular salivary gland formation [GO:0060661]; substantia nigra development [GO:0021762]; T cell costimulation [GO:0031295]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	actin cytoskeleton organization [GO:0030036]; actin filament branching [GO:0090135]; actin filament bundle assembly [GO:0051017]; adherens junction organization [GO:0034332]; axon guidance [GO:0007411]; blood coagulation [GO:0007596]; canonical Wnt signaling pathway [GO:0060070]; cardiac conduction system development [GO:0003161]; cellular protein localization [GO:0034613]; dendritic cell migration [GO:0036336]; ephrin receptor signaling pathway [GO:0048013]; epidermal growth factor receptor signaling pathway [GO:0007173]; epithelial cell-cell adhesion [GO:0090136]; epithelial-mesenchymal cell signaling [GO:0060684]; establishment of Golgi localization [GO:0051683]; establishment or maintenance of apical/basal cell polarity [GO:0035088]; establishment or maintenance of cell polarity [GO:0007163]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; filopodium assembly [GO:0046847]; Golgi organization [GO:0007030]; hair follicle morphogenesis [GO:0031069]; hair follicle placode formation [GO:0060789]; heart contraction [GO:0060047]; innate immune response [GO:0045087]; keratinization [GO:0031424]; keratinocyte development [GO:0003334]; macrophage differentiation [GO:0030225]; metabolic process [GO:0008152]; multicellular organism growth [GO:0035264]; muscle cell differentiation [GO:0042692]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of gene expression [GO:0010629]; negative regulation of protein complex assembly [GO:0031333]; neuron fate determination [GO:0048664]; nuclear migration [GO:0007097]; organelle transport along microtubule [GO:0072384]; positive regulation of cytokinesis [GO:0032467]; positive regulation of DNA replication [GO:0045740]; positive regulation of gene expression [GO:0010628]; positive regulation of hair follicle cell proliferation [GO:0071338]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of JNK cascade [GO:0046330]; positive regulation of metalloenzyme activity [GO:0048554]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of pseudopodium assembly [GO:0031274]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of synapse structural plasticity [GO:0051835]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of filopodium assembly [GO:0051489]; regulation of mitotic nuclear division [GO:0007088]; regulation of protein catabolic process [GO:0042176]; regulation of protein heterodimerization activity [GO:0043497]; regulation of protein kinase activity [GO:0045859]; regulation of protein stability [GO:0031647]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]; sprouting angiogenesis [GO:0002040]; submandibular salivary gland formation [GO:0060661]; substantia nigra development [GO:0021762]; T cell costimulation [GO:0031295]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	apolipoprotein A-I receptor binding [GO:0034191]; GTPase activity [GO:0003924]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; thioesterase binding [GO:0031996]	apical part of cell [GO:0045177]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; leading edge membrane [GO:0031256]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; neuronal cell body [GO:0043025]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]; spindle midzone [GO:0051233]	GO:0038096; GO:0005525; GO:0003924; GO:0000139; GO:0007030; GO:0031295; GO:0030036; GO:0090135; GO:0051017; GO:0034332; GO:0045177; GO:0034191; GO:0007411; GO:0007596; GO:0060070; GO:0003161; GO:0005911; GO:0034613; GO:0005737; GO:0036464; GO:0005829; GO:0036336; GO:0005789; GO:0048013; GO:0007173; GO:0090136; GO:0060684; GO:0051683; GO:0035088; GO:0007163; GO:0070062; GO:0030175; GO:0046847; GO:0005925; GO:0031069; GO:0060789; GO:0060047; GO:0042802; GO:0045087; GO:0031424; GO:0003334; GO:0031256; GO:0030225; GO:0016020; GO:0008152; GO:0005815; GO:0030496; GO:0072686; GO:0035264; GO:0042692; GO:0042059; GO:0010629; GO:0031333; GO:0048664; GO:0043005; GO:0043025; GO:0007097; GO:0072384; GO:0005886; GO:0045740; GO:0046330; GO:0032467; GO:0010628; GO:0071338; GO:0090316; GO:0048554; GO:0051149; GO:0043525; GO:0033138; GO:0043552; GO:0031274; GO:1900026; GO:0051835; GO:0019901; GO:0051988; GO:0051489; GO:0007088; GO:0042176; GO:0043497; GO:0045859; GO:0031647; GO:0051056; GO:0030141; GO:0007264; GO:0051233; GO:0002040; GO:0060661; GO:0021762; GO:0031996; GO:0048010	SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Localizes to spindle during prometaphase cells. Moves to the central spindle as cells progressed through anaphase to telophase. Localizes at the end of cytokinesis in the intercellular bridge formed between two daughter cells. Its localization is regulated by the activities of guanine nucleotide exchange factor ECT2 and GTPase activating protein RACGAP1. Colocalizes with NEK6 in the centrosome.	3D-structure; Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Differentiation; Direct protein sequencing; GTP-binding; Lipoprotein; Membrane; Methylation; Neurogenesis; Nucleotide-binding; Phosphoprotein; Prenylation; Reference proteome	Alternative sequence (2); Beta strand (9); Chain (1); Helix (10); Lipidation (1); Modified residue (4); Motif (1); Mutagenesis (4); Nucleotide binding (3); Propeptide (1); Turn (6)
GFPT1_HUMAN	Q06210	GFPT1_HUMAN	reviewed	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 1) (Glutamine:fructose-6-phosphate amidotransferase 1) (GFAT 1) (GFAT1) (Hexosephosphate aminotransferase 1)	GFPT1 GFAT GFPT	Homo sapiens (Human)	699	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; amino acid binding [GO:0016597]; carbohydrate binding [GO:0030246]; glutamine-fructose-6-phosphate transaminase (isomerizing) activity [GO:0004360]; cellular protein metabolic process [GO:0044267]; cellular response to insulin stimulus [GO:0032869]; circadian regulation of gene expression [GO:0032922]; dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; endoplasmic reticulum unfolded protein response [GO:0030968]; energy reserve metabolic process [GO:0006112]; fructose 6-phosphate metabolic process [GO:0006002]; glucosamine biosynthetic process [GO:0006042]; glutamine metabolic process [GO:0006541]; IRE1-mediated unfolded protein response [GO:0036498]; negative regulation of glycogen biosynthetic process [GO:0045719]; post-translational protein modification [GO:0043687]; protein homotetramerization [GO:0051289]; protein N-linked glycosylation via asparagine [GO:0018279]; response to sucrose [GO:0009744]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]	cellular protein metabolic process [GO:0044267]; cellular response to insulin stimulus [GO:0032869]; circadian regulation of gene expression [GO:0032922]; dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; endoplasmic reticulum unfolded protein response [GO:0030968]; energy reserve metabolic process [GO:0006112]; fructose 6-phosphate metabolic process [GO:0006002]; glucosamine biosynthetic process [GO:0006042]; glutamine metabolic process [GO:0006541]; IRE1-mediated unfolded protein response [GO:0036498]; negative regulation of glycogen biosynthetic process [GO:0045719]; post-translational protein modification [GO:0043687]; protein homotetramerization [GO:0051289]; protein N-linked glycosylation via asparagine [GO:0018279]; response to sucrose [GO:0009744]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]	amino acid binding [GO:0016597]; carbohydrate binding [GO:0030246]; glutamine-fructose-6-phosphate transaminase (isomerizing) activity [GO:0004360]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0036498; GO:0006048; GO:0016597; GO:0030246; GO:0044267; GO:0032869; GO:0032922; GO:0005829; GO:0006488; GO:0030968; GO:0006112; GO:0070062; GO:0006002; GO:0006042; GO:0006541; GO:0004360; GO:0045719; GO:0043687; GO:0018279; GO:0051289; GO:0009744		3D-structure; Alternative splicing; Aminotransferase; Biological rhythms; Complete proteome; Congenital myasthenic syndrome; Disease mutation; Glutamine amidotransferase; Phosphoprotein; Reference proteome; Repeat; Transferase	Active site (1); Alternative sequence (1); Beta strand (14); Binding site (2); Chain (1); Domain (3); Helix (20); Initiator methionine (1); Modified residue (1); Natural variant (13); Region (3); Turn (5)
PSME2_HUMAN	Q9UL46	PSME2_HUMAN	reviewed	Proteasome activator complex subunit 2 (11S regulator complex subunit beta) (REG-beta) (Activator of multicatalytic protease subunit 2) (Proteasome activator 28 subunit beta) (PA28b) (PA28beta)	PSME2	Homo sapiens (Human)	239	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; proteasome activator complex [GO:0008537]; proteasome complex [GO:0000502]; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]		cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; proteasome activator complex [GO:0008537]; proteasome complex [GO:0000502]	GO:0006977; GO:0000082; GO:0031145; GO:0042590; GO:0002479; GO:0002474; GO:0006915; GO:0034641; GO:0005829; GO:0070062; GO:0010467; GO:0045087; GO:0016020; GO:0000278; GO:0043066; GO:0090090; GO:0051436; GO:0005654; GO:0090263; GO:0051437; GO:0012501; GO:0008537; GO:0000502; GO:0000209; GO:0042981; GO:0006521; GO:0051439; GO:0044281; GO:0002223; GO:0016032		Acetylation; Complete proteome; Direct protein sequencing; Phosphoprotein; Polymorphism; Proteasome; Reference proteome	Chain (1); Initiator methionine (1); Modified residue (2); Natural variant (1); Sequence conflict (1)
EF1B_HUMAN	P24534	EF1B_HUMAN	reviewed	Elongation factor 1-beta (EF-1-beta)	EEF1B2 EEF1B EF1B	Homo sapiens (Human)	225	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation elongation factor 1 complex [GO:0005853]; translation elongation factor activity [GO:0003746]; cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; translation [GO:0006412]; translational elongation [GO:0006414]	cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; translation [GO:0006412]; translational elongation [GO:0006414]	translation elongation factor activity [GO:0003746]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation elongation factor 1 complex [GO:0005853]	GO:0044267; GO:0005737; GO:0005829; GO:0005853; GO:0010467; GO:0006412; GO:0003746; GO:0006414		3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Elongation factor; Phosphoprotein; Protein biosynthesis; Reference proteome	Beta strand (4); Chain (1); Domain (1); Helix (2); Initiator methionine (1); Modified residue (6); Turn (1)
MY18A_HUMAN	Q92614	MY18A_HUMAN	reviewed	Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain)	MYO18A KIAA0216 MYSPDZ	Homo sapiens (Human)	2054	actomyosin [GO:0042641]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; myosin complex [GO:0016459]; trans-Golgi network [GO:0005802]; actin filament binding [GO:0051015]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; motor activity [GO:0003774]; poly(A) RNA binding [GO:0044822]; actomyosin structure organization [GO:0031032]; asymmetric Golgi ribbon formation [GO:0090164]; cell migration [GO:0016477]; DNA metabolic process [GO:0006259]; Golgi organization [GO:0007030]; Golgi ribbon formation [GO:0090161]; Golgi vesicle budding [GO:0048194]; negative regulation of apoptotic process [GO:0043066]; positive regulation of protein secretion [GO:0050714]	actomyosin structure organization [GO:0031032]; asymmetric Golgi ribbon formation [GO:0090164]; cell migration [GO:0016477]; DNA metabolic process [GO:0006259]; Golgi organization [GO:0007030]; Golgi ribbon formation [GO:0090161]; Golgi vesicle budding [GO:0048194]; negative regulation of apoptotic process [GO:0043066]; positive regulation of protein secretion [GO:0050714]	actin filament binding [GO:0051015]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; motor activity [GO:0003774]; poly(A) RNA binding [GO:0044822]	actomyosin [GO:0042641]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; myosin complex [GO:0016459]; trans-Golgi network [GO:0005802]	GO:0043531; GO:0005524; GO:0003677; GO:0006259; GO:0000139; GO:0007030; GO:0090161; GO:0048194; GO:0051015; GO:0042641; GO:0031032; GO:0090164; GO:0016477; GO:0005793; GO:0016020; GO:0003774; GO:0016459; GO:0043066; GO:0044822; GO:0050714; GO:0005802	SUBCELLULAR LOCATION: Isoform 1: Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250}. Cytoplasm, cytoskeleton. Note=Colocalizes with actin.; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm. Note=Lacks the PDZ domain. Diffusely localized in the cytoplasm.; SUBCELLULAR LOCATION: Golgi apparatus. Golgi apparatus, trans-Golgi network. Note=Recruited to the Golgi apparatus by GOLPH3.	ATP-binding; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Golgi apparatus; Motor protein; Myosin; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome	Alternative sequence (5); Chain (1); Coiled coil (1); Compositional bias (1); Domain (3); Erroneous initiation (2); Modified residue (26); Motif (1); Mutagenesis (2); Natural variant (1); Nucleotide binding (1); Region (1); Sequence conflict (4)
U2AF2_HUMAN	P26368	U2AF2_HUMAN	reviewed	Splicing factor U2AF 65 kDa subunit (U2 auxiliary factor 65 kDa subunit) (hU2AF(65)) (hU2AF65) (U2 snRNP auxiliary factor large subunit)	U2AF2 U2AF65	Homo sapiens (Human)	475	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; enzyme binding [GO:0019899]; nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; gene expression [GO:0010467]; mRNA 3'-end processing [GO:0031124]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of RNA splicing [GO:0033120]; regulation of mitochondrion degradation [GO:1903146]; RNA splicing [GO:0008380]; termination of RNA polymerase II transcription [GO:0006369]; transcription from RNA polymerase II promoter [GO:0006366]	gene expression [GO:0010467]; mRNA 3'-end processing [GO:0031124]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of RNA splicing [GO:0033120]; regulation of mitochondrion degradation [GO:1903146]; RNA splicing [GO:0008380]; termination of RNA polymerase II transcription [GO:0006369]; transcription from RNA polymerase II promoter [GO:0006366]	enzyme binding [GO:0019899]; nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]	GO:0008380; GO:0019899; GO:0010467; GO:0031124; GO:0006406; GO:0006397; GO:0000398; GO:0048025; GO:0016607; GO:0005654; GO:0000166; GO:0044822; GO:0033120; GO:1903955; GO:1903146; GO:0005681; GO:0006369; GO:0006366	SUBCELLULAR LOCATION: Nucleus.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Hydroxylation; Nucleus; Phosphoprotein; RNA-binding; Reference proteome; Repeat; Repressor; Spliceosome; mRNA processing; mRNA splicing	Alternative sequence (1); Beta strand (19); Chain (1); Compositional bias (1); Domain (3); Helix (10); Initiator methionine (1); Modified residue (6); Mutagenesis (10); Region (1); Turn (4)
TYSY_HUMAN	P04818	TYSY_HUMAN	reviewed	Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)	TYMS TS OK/SW-cl.29	Homo sapiens (Human)	313	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cofactor binding [GO:0048037]; drug binding [GO:0008144]; folic acid binding [GO:0005542]; mRNA binding [GO:0003729]; nucleotide binding [GO:0000166]; thymidylate synthase activity [GO:0004799]; aging [GO:0007568]; cartilage development [GO:0051216]; circadian rhythm [GO:0007623]; deoxyribonucleoside monophosphate biosynthetic process [GO:0009157]; developmental growth [GO:0048589]; dTMP biosynthetic process [GO:0006231]; dTTP biosynthetic process [GO:0006235]; dUMP metabolic process [GO:0046078]; G1/S transition of mitotic cell cycle [GO:0000082]; immortalization of host cell by virus [GO:0019088]; intestinal epithelial cell maturation [GO:0060574]; mitotic cell cycle [GO:0000278]; nucleobase-containing compound metabolic process [GO:0006139]; nucleobase-containing small molecule metabolic process [GO:0055086]; organ regeneration [GO:0031100]; pyrimidine nucleobase metabolic process [GO:0006206]; pyrimidine nucleoside biosynthetic process [GO:0046134]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]; response to cytokine [GO:0034097]; response to drug [GO:0042493]; response to ethanol [GO:0045471]; response to folic acid [GO:0051593]; response to glucocorticoid [GO:0051384]; response to organophosphorus [GO:0046683]; response to progesterone [GO:0032570]; response to toxic substance [GO:0009636]; response to vitamin A [GO:0033189]; small molecule metabolic process [GO:0044281]; tetrahydrofolate metabolic process [GO:0046653]; uracil metabolic process [GO:0019860]	aging [GO:0007568]; cartilage development [GO:0051216]; circadian rhythm [GO:0007623]; deoxyribonucleoside monophosphate biosynthetic process [GO:0009157]; developmental growth [GO:0048589]; dTMP biosynthetic process [GO:0006231]; dTTP biosynthetic process [GO:0006235]; dUMP metabolic process [GO:0046078]; G1/S transition of mitotic cell cycle [GO:0000082]; immortalization of host cell by virus [GO:0019088]; intestinal epithelial cell maturation [GO:0060574]; mitotic cell cycle [GO:0000278]; nucleobase-containing compound metabolic process [GO:0006139]; nucleobase-containing small molecule metabolic process [GO:0055086]; organ regeneration [GO:0031100]; pyrimidine nucleobase metabolic process [GO:0006206]; pyrimidine nucleoside biosynthetic process [GO:0046134]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]; response to cytokine [GO:0034097]; response to drug [GO:0042493]; response to ethanol [GO:0045471]; response to folic acid [GO:0051593]; response to glucocorticoid [GO:0051384]; response to organophosphorus [GO:0046683]; response to progesterone [GO:0032570]; response to toxic substance [GO:0009636]; response to vitamin A [GO:0033189]; small molecule metabolic process [GO:0044281]; tetrahydrofolate metabolic process [GO:0046653]; uracil metabolic process [GO:0019860]	cofactor binding [GO:0048037]; drug binding [GO:0008144]; folic acid binding [GO:0005542]; mRNA binding [GO:0003729]; nucleotide binding [GO:0000166]; thymidylate synthase activity [GO:0004799]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000082; GO:0007568; GO:0051216; GO:0007623; GO:0048037; GO:0005737; GO:0005829; GO:0006231; GO:0006235; GO:0046078; GO:0009157; GO:0048589; GO:0008144; GO:0005542; GO:0019088; GO:0060574; GO:0003729; GO:0005743; GO:0005759; GO:0005739; GO:0000278; GO:0006139; GO:0055086; GO:0005730; GO:0005654; GO:0000166; GO:0005634; GO:0031100; GO:0006206; GO:0046134; GO:0000083; GO:0034097; GO:0042493; GO:0045471; GO:0051593; GO:0051384; GO:0046683; GO:0032570; GO:0009636; GO:0033189; GO:0044281; GO:0046653; GO:0004799; GO:0019860	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21876188}. Cytoplasm {ECO:0000269|PubMed:21876188}. Mitochondrion {ECO:0000269|PubMed:21876188}. Mitochondrion matrix {ECO:0000269|PubMed:21876188}. Mitochondrion inner membrane {ECO:0000269|PubMed:21876188}.	3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Membrane; Methyltransferase; Mitochondrion; Mitochondrion inner membrane; Nucleotide biosynthesis; Nucleus; Phosphoprotein; Reference proteome; Transferase	Active site (1); Alternative sequence (2); Beta strand (13); Chain (1); Helix (14); Initiator methionine (1); Modified residue (1); Turn (6)
SPEE_HUMAN	P19623	SPEE_HUMAN	reviewed	Spermidine synthase (SPDSY) (EC 2.5.1.16) (Putrescine aminopropyltransferase)	SRM SPS1 SRML1	Homo sapiens (Human)	302	cytosol [GO:0005829]; protein homodimerization activity [GO:0042803]; spermidine synthase activity [GO:0004766]; cellular nitrogen compound metabolic process [GO:0034641]; polyamine metabolic process [GO:0006595]; small molecule metabolic process [GO:0044281]; spermidine biosynthetic process [GO:0008295]	cellular nitrogen compound metabolic process [GO:0034641]; polyamine metabolic process [GO:0006595]; small molecule metabolic process [GO:0044281]; spermidine biosynthetic process [GO:0008295]	protein homodimerization activity [GO:0042803]; spermidine synthase activity [GO:0004766]	cytosol [GO:0005829]	GO:0034641; GO:0005829; GO:0006595; GO:0042803; GO:0044281; GO:0008295; GO:0004766		3D-structure; Acetylation; Complete proteome; Polyamine biosynthesis; Polymorphism; Reference proteome; Spermidine biosynthesis; Transferase	Active site (1); Beta strand (14); Binding site (7); Chain (1); Domain (1); Helix (13); Modified residue (1); Natural variant (1); Region (2); Sequence conflict (1); Turn (2)
ACOC_HUMAN	P21399	ACOC_HUMAN	reviewed	Cytoplasmic aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (Ferritin repressor protein) (Iron regulatory protein 1) (IRP1) (Iron-responsive element-binding protein 1) (IRE-BP 1)	ACO1 IREB1	Homo sapiens (Human)	889	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; 4 iron, 4 sulfur cluster binding [GO:0051539]; aconitate hydratase activity [GO:0003994]; iron-responsive element binding [GO:0030350]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; cellular iron ion homeostasis [GO:0006879]; citrate metabolic process [GO:0006101]; intestinal absorption [GO:0050892]; post-embryonic development [GO:0009791]; regulation of translation [GO:0006417]; response to iron(II) ion [GO:0010040]; tricarboxylic acid cycle [GO:0006099]	cellular iron ion homeostasis [GO:0006879]; citrate metabolic process [GO:0006101]; intestinal absorption [GO:0050892]; post-embryonic development [GO:0009791]; regulation of translation [GO:0006417]; response to iron(II) ion [GO:0010040]; tricarboxylic acid cycle [GO:0006099]	4 iron, 4 sulfur cluster binding [GO:0051539]; aconitate hydratase activity [GO:0003994]; iron-responsive element binding [GO:0030350]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]	GO:0051539; GO:0005794; GO:0003723; GO:0003994; GO:0006879; GO:0006101; GO:0005737; GO:0005829; GO:0005783; GO:0070062; GO:0050892; GO:0030350; GO:0046872; GO:0005739; GO:0009791; GO:0006417; GO:0010040; GO:0006099	SUBCELLULAR LOCATION: Cytoplasm.	3D-structure; 4Fe-4S; Complete proteome; Cytoplasm; Direct protein sequencing; Iron; Iron-sulfur; Lyase; Metal-binding; Phosphoprotein; Polymorphism; RNA-binding; Reference proteome; Tricarboxylic acid cycle	Beta strand (40); Binding site (4); Chain (1); Helix (46); Metal binding (3); Modified residue (1); Mutagenesis (9); Natural variant (3); Region (2); Turn (8)
PDC6I_HUMAN	Q8WUM4	PDC6I_HUMAN	reviewed	Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95)	PDCD6IP AIP1 ALIX KIAA1375	Homo sapiens (Human)	868	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; focal adhesion [GO:0005925]; immunological synapse [GO:0001772]; melanosome [GO:0042470]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; calcium-dependent protein binding [GO:0048306]; protein homodimerization activity [GO:0042803]; proteinase activated receptor binding [GO:0031871]; apoptotic process [GO:0006915]; cell cycle [GO:0007049]; cell separation after cytokinesis [GO:0000920]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of extracellular exosome assembly [GO:1903553]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of extracellular exosome assembly [GO:1903551]; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611]; viral budding via host ESCRT complex [GO:0039702]; viral life cycle [GO:0019058]; viral process [GO:0016032]	apoptotic process [GO:0006915]; cell cycle [GO:0007049]; cell separation after cytokinesis [GO:0000920]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of extracellular exosome assembly [GO:1903553]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of extracellular exosome assembly [GO:1903551]; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611]; viral budding via host ESCRT complex [GO:0039702]; viral life cycle [GO:0019058]; viral process [GO:0016032]	calcium-dependent protein binding [GO:0048306]; proteinase activated receptor binding [GO:0031871]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; focal adhesion [GO:0005925]; immunological synapse [GO:0001772]; melanosome [GO:0042470]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]	GO:0006915; GO:0048306; GO:0007049; GO:0000920; GO:0005737; GO:0005829; GO:0070971; GO:0070062; GO:1903561; GO:0005925; GO:0001772; GO:0042470; GO:0016020; GO:0005815; GO:1903543; GO:1903553; GO:0042803; GO:0015031; GO:0031871; GO:0010824; GO:1903551; GO:0090611; GO:0039702; GO:0019058; GO:0016032	SUBCELLULAR LOCATION: Cytoplasm, cytosol. Melanosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Colocalized with CEP55 in the midbody during cytokinesis. Colocalized with CEP55 at centrosomes of non-dividing cells.	3D-structure; Acetylation; Alternative splicing; Apoptosis; Cell cycle; Cell division; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Host-virus interaction; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport	Alternative sequence (3); Beta strand (11); Chain (1); Compositional bias (1); Domain (1); Erroneous initiation (1); Helix (23); Initiator methionine (1); Modified residue (5); Mutagenesis (21); Natural variant (7); Region (6); Sequence conflict (1); Turn (9)
PSMD6_HUMAN	Q15008	PSMD6_HUMAN	reviewed	26S proteasome non-ATPase regulatory subunit 6 (26S proteasome regulatory subunit RPN7) (26S proteasome regulatory subunit S10) (Breast cancer-associated protein SGA-113M) (Phosphonoformate immuno-associated protein 4) (Proteasome regulatory particle subunit p44S10) (p42A)	PSMD6 KIAA0107 PFAAP4	Homo sapiens (Human)	389	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; ATPase activity [GO:0016887]; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; proteolysis [GO:0006508]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	ATPase activity [GO:0016887]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]	GO:0016887; GO:0006977; GO:0000082; GO:0031145; GO:0042590; GO:0002479; GO:0002474; GO:0006915; GO:0034641; GO:0005829; GO:0070062; GO:0010467; GO:0045087; GO:0000278; GO:0043066; GO:0090090; GO:0051436; GO:0005654; GO:0090263; GO:0051437; GO:0012501; GO:0022624; GO:0000502; GO:0005838; GO:0043161; GO:0000209; GO:0006508; GO:0042981; GO:0006521; GO:0051439; GO:0044281; GO:0002223; GO:0016032		Alternative splicing; Complete proteome; Proteasome; Reference proteome	Alternative sequence (3); Chain (1); Domain (1)
OGFR_HUMAN	Q9NZT2	OGFR_HUMAN	reviewed	Opioid growth factor receptor (OGFr) (Protein 7-60) (Zeta-type opioid receptor)	OGFR	Homo sapiens (Human)	677	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]; opioid receptor activity [GO:0004985]; opioid receptor signaling pathway [GO:0038003]; regulation of cell growth [GO:0001558]	opioid receptor signaling pathway [GO:0038003]; regulation of cell growth [GO:0001558]	opioid receptor activity [GO:0004985]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]	GO:0005737; GO:0016020; GO:0005634; GO:0004985; GO:0038003; GO:0001558	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=The OGF/OGFR complex is probably translocated to the nucleus.	Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Growth regulation; Nucleus; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat	Alternative sequence (1); Chain (1); Erroneous gene model prediction (1); Frameshift (2); Modified residue (9); Motif (1); Natural variant (2); Region (1); Repeat (7); Sequence conflict (22)
PPCE_HUMAN	P48147	PPCE_HUMAN	reviewed	Prolyl endopeptidase (PE) (EC 3.4.21.26) (Post-proline cleaving enzyme)	PREP PEP	Homo sapiens (Human)	710	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]; serine-type endopeptidase activity [GO:0004252]; serine-type exopeptidase activity [GO:0070008]; serine-type peptidase activity [GO:0008236]; proteolysis [GO:0006508]	proteolysis [GO:0006508]	serine-type endopeptidase activity [GO:0004252]; serine-type exopeptidase activity [GO:0070008]; serine-type peptidase activity [GO:0008236]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]	GO:0005737; GO:0016020; GO:0005634; GO:0006508; GO:0004252; GO:0070008; GO:0008236	SUBCELLULAR LOCATION: Cytoplasm.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Polymorphism; Protease; Reference proteome; Serine protease	Active site (3); Beta strand (44); Chain (1); Helix (22); Modified residue (2); Natural variant (2); Sequence conflict (8); Turn (5)
C1TM_HUMAN	Q6UB35	C1TM_HUMAN	reviewed	Monofunctional C1-tetrahydrofolate synthase, mitochondrial (EC 6.3.4.3) (Formyltetrahydrofolate synthetase)	MTHFD1L FTHFSDC1	Homo sapiens (Human)	978	membrane [GO:0016020]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; formate-tetrahydrofolate ligase activity [GO:0004329]; protein homodimerization activity [GO:0042803]; folic acid-containing compound biosynthetic process [GO:0009396]; folic acid-containing compound metabolic process [GO:0006760]; formate metabolic process [GO:0015942]; one-carbon metabolic process [GO:0006730]; oxidation-reduction process [GO:0055114]; tetrahydrofolate interconversion [GO:0035999]; tetrahydrofolate metabolic process [GO:0046653]	folic acid-containing compound biosynthetic process [GO:0009396]; folic acid-containing compound metabolic process [GO:0006760]; formate metabolic process [GO:0015942]; one-carbon metabolic process [GO:0006730]; oxidation-reduction process [GO:0055114]; tetrahydrofolate interconversion [GO:0035999]; tetrahydrofolate metabolic process [GO:0046653]	ATP binding [GO:0005524]; formate-tetrahydrofolate ligase activity [GO:0004329]; protein homodimerization activity [GO:0042803]	membrane [GO:0016020]; mitochondrion [GO:0005739]	GO:0005524; GO:0009396; GO:0006760; GO:0015942; GO:0004329; GO:0016020; GO:0005739; GO:0006730; GO:0055114; GO:0042803; GO:0035999; GO:0046653	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:12937168}.	ATP-binding; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Ligase; Mitochondrion; Nucleotide-binding; One-carbon metabolism; Polymorphism; Reference proteome; Transit peptide	Alternative sequence (2); Chain (1); Compositional bias (1); Erroneous initiation (2); Modified residue (3); Natural variant (1); Nucleotide binding (1); Region (2); Sequence conflict (2); Transit peptide (1)
PRDX6_HUMAN	P30041	PRDX6_HUMAN	reviewed	Peroxiredoxin-6 (EC 1.11.1.15) (1-Cys peroxiredoxin) (1-Cys PRX) (24 kDa protein) (Acidic calcium-independent phospholipase A2) (aiPLA2) (EC 3.1.1.-) (Antioxidant protein 2) (Liver 2D page spot 40) (Non-selenium glutathione peroxidase) (NSGPx) (EC 1.11.1.9) (Red blood cells page spot 12)	PRDX6 AOP2 KIAA0106	Homo sapiens (Human)	224	cytoplasm [GO:0005737]; cytoplasmic membrane-bounded vesicle [GO:0016023]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; lysosome [GO:0005764]; membrane [GO:0016020]; antioxidant activity [GO:0016209]; glutathione peroxidase activity [GO:0004602]; peroxiredoxin activity [GO:0051920]; phospholipase A2 activity [GO:0004623]; ubiquitin protein ligase binding [GO:0031625]; hydrogen peroxide catabolic process [GO:0042744]; phospholipid catabolic process [GO:0009395]; response to oxidative stress [GO:0006979]; response to reactive oxygen species [GO:0000302]	hydrogen peroxide catabolic process [GO:0042744]; phospholipid catabolic process [GO:0009395]; response to oxidative stress [GO:0006979]; response to reactive oxygen species [GO:0000302]	antioxidant activity [GO:0016209]; glutathione peroxidase activity [GO:0004602]; peroxiredoxin activity [GO:0051920]; phospholipase A2 activity [GO:0004623]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytoplasmic membrane-bounded vesicle [GO:0016023]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; lysosome [GO:0005764]; membrane [GO:0016020]	GO:0016209; GO:0005737; GO:0016023; GO:0005829; GO:0070062; GO:0005615; GO:0004602; GO:0042744; GO:0005764; GO:0016020; GO:0051920; GO:0004623; GO:0009395; GO:0006979; GO:0000302; GO:0031625	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16186110, ECO:0000269|PubMed:19188445}. Lysosome {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Also found in lung secretory organelles. {ECO:0000250}.	3D-structure; Acetylation; Antioxidant; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Direct protein sequencing; Disulfide bond; Hydrolase; Lipid degradation; Lipid metabolism; Lysosome; Multifunctional enzyme; Oxidoreductase; Peroxidase; Phosphoprotein; Redox-active center; Reference proteome	Active site (2); Beta strand (11); Chain (1); Disulfide bond (1); Domain (1); Helix (6); Initiator methionine (1); Modified residue (5); Mutagenesis (2); Turn (1)
RBM10_HUMAN	P98175	RBM10_HUMAN	reviewed	RNA-binding protein 10 (G patch domain-containing protein 9) (RNA-binding motif protein 10) (RNA-binding protein S1-1) (S1-1)	RBM10 DXS8237E GPATC9 GPATCH9 KIAA0122	Homo sapiens (Human)	930	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; protein complex binding [GO:0032403]; zinc ion binding [GO:0008270]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]	mRNA processing [GO:0006397]; RNA splicing [GO:0008380]	identical protein binding [GO:0042802]; nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; protein complex binding [GO:0032403]; zinc ion binding [GO:0008270]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0008380; GO:0042802; GO:0006397; GO:0005654; GO:0000166; GO:0005634; GO:0044822; GO:0032403; GO:0008270	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18315527}. Note=In the extranucleolar nucleoplasm constitutes hundreds of nuclear domains, which dynamically change their structures in a reversible manner. Upon globally reducing RNA polymerase II transcription, the nuclear bodies enlarge and decrease in number. They occur closely adjacent to nuclear speckles or IGCs (interchromatin granule clusters) but coincide with TIDRs (transcription-inactivation-dependent RNA domains).	3D-structure; Acetylation; Alternative splicing; Complete proteome; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; RNA-binding; Reference proteome; Repeat; Zinc; Zinc-finger; mRNA processing; mRNA splicing	Alternative sequence (2); Beta strand (17); Chain (1); Compositional bias (3); Domain (3); Erroneous initiation (2); Frameshift (2); Helix (7); Modified residue (10); Natural variant (1); Sequence conflict (2); Turn (6); Zinc finger (2)
DSRAD_HUMAN	P55265	DSRAD_HUMAN	reviewed	Double-stranded RNA-specific adenosine deaminase (DRADA) (EC 3.5.4.37) (136 kDa double-stranded RNA-binding protein) (p136) (Interferon-inducible protein 4) (IFI-4) (K88DSRBP)	ADAR ADAR1 DSRAD G1P1 IFI4	Homo sapiens (Human)	1226	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; supraspliceosomal complex [GO:0044530]; DNA binding [GO:0003677]; double-stranded RNA adenosine deaminase activity [GO:0003726]; metal ion binding [GO:0046872]; poly(A) RNA binding [GO:0044822]; adenosine to inosine editing [GO:0006382]; base conversion or substitution editing [GO:0016553]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; definitive hemopoiesis [GO:0060216]; erythrocyte differentiation [GO:0030218]; gene expression [GO:0010467]; hematopoietic progenitor cell differentiation [GO:0002244]; hematopoietic stem cell homeostasis [GO:0061484]; in utero embryonic development [GO:0001701]; innate immune response [GO:0045087]; miRNA loading onto RISC involved in gene silencing by miRNA [GO:0035280]; mRNA modification [GO:0016556]; mRNA processing [GO:0006397]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; negative regulation of RNA interference [GO:1900369]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; negative regulation of viral genome replication [GO:0045071]; osteoblast differentiation [GO:0001649]; positive regulation of viral genome replication [GO:0045070]; pre-miRNA processing [GO:0031054]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]; response to interferon-alpha [GO:0035455]; response to virus [GO:0009615]; somatic diversification of immune receptors via somatic mutation [GO:0002566]; type I interferon signaling pathway [GO:0060337]	adenosine to inosine editing [GO:0006382]; base conversion or substitution editing [GO:0016553]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; definitive hemopoiesis [GO:0060216]; erythrocyte differentiation [GO:0030218]; gene expression [GO:0010467]; hematopoietic progenitor cell differentiation [GO:0002244]; hematopoietic stem cell homeostasis [GO:0061484]; innate immune response [GO:0045087]; in utero embryonic development [GO:0001701]; miRNA loading onto RISC involved in gene silencing by miRNA [GO:0035280]; mRNA modification [GO:0016556]; mRNA processing [GO:0006397]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; negative regulation of RNA interference [GO:1900369]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; negative regulation of viral genome replication [GO:0045071]; osteoblast differentiation [GO:0001649]; positive regulation of viral genome replication [GO:0045070]; pre-miRNA processing [GO:0031054]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]; response to interferon-alpha [GO:0035455]; response to virus [GO:0009615]; somatic diversification of immune receptors via somatic mutation [GO:0002566]; type I interferon signaling pathway [GO:0060337]	DNA binding [GO:0003677]; double-stranded RNA adenosine deaminase activity [GO:0003726]; metal ion binding [GO:0046872]; poly(A) RNA binding [GO:0044822]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; supraspliceosomal complex [GO:0044530]	GO:0003677; GO:0006382; GO:0016553; GO:0019221; GO:0005737; GO:0051607; GO:0060216; GO:0003726; GO:0030218; GO:0010467; GO:0002244; GO:0061484; GO:0001701; GO:0045087; GO:0016556; GO:0006397; GO:0016020; GO:0046872; GO:0035280; GO:1900369; GO:0043066; GO:0044387; GO:0060339; GO:0045071; GO:0005730; GO:0005654; GO:0005634; GO:0001649; GO:0044822; GO:0045070; GO:0031054; GO:0006611; GO:0006606; GO:0035455; GO:0009615; GO:0002566; GO:0044530; GO:0060337	SUBCELLULAR LOCATION: Isoform 1: Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and nucleus.; SUBCELLULAR LOCATION: Isoform 5: Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Predominantly nuclear but can shuttle between nucleus and cytoplasm. TNPO1 can mediate its nuclear import whereas XPO1 can mediate its nuclear export.	3D-structure; Aicardi-Goutieres syndrome; Alternative promoter usage; Alternative splicing; Antiviral defense; Complete proteome; Cytoplasm; DNA-binding; Direct protein sequencing; Disease mutation; Hydrolase; Immunity; Innate immunity; Isopeptide bond; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; RNA-binding; RNA-mediated gene silencing; Reference proteome; Repeat; Ubl conjugation; Zinc; mRNA processing	Active site (1); Alternative sequence (4); Beta strand (9); Chain (1); Cross-link (1); DNA binding (1); Domain (4); Erroneous termination (1); Helix (12); Metal binding (3); Modified residue (5); Mutagenesis (1); Natural variant (16); Repeat (2); Sequence conflict (10); Turn (1)
PNPH_HUMAN	P00491	PNPH_HUMAN	reviewed	Purine nucleoside phosphorylase (PNP) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase)	PNP NP	Homo sapiens (Human)	289	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular [GO:0005622]; drug binding [GO:0008144]; nucleoside binding [GO:0001882]; phosphate ion binding [GO:0042301]; purine nucleobase binding [GO:0002060]; purine-nucleoside phosphorylase activity [GO:0004731]; immune response [GO:0006955]; inosine catabolic process [GO:0006148]; interleukin-2 secretion [GO:0070970]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; nicotinamide riboside catabolic process [GO:0006738]; nucleobase-containing compound metabolic process [GO:0006139]; nucleobase-containing small molecule metabolic process [GO:0055086]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of T cell proliferation [GO:0042102]; purine nucleobase metabolic process [GO:0006144]; purine nucleotide catabolic process [GO:0006195]; purine-containing compound salvage [GO:0043101]; response to drug [GO:0042493]; small molecule metabolic process [GO:0044281]; urate biosynthetic process [GO:0034418]	immune response [GO:0006955]; inosine catabolic process [GO:0006148]; interleukin-2 secretion [GO:0070970]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; nicotinamide riboside catabolic process [GO:0006738]; nucleobase-containing compound metabolic process [GO:0006139]; nucleobase-containing small molecule metabolic process [GO:0055086]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of T cell proliferation [GO:0042102]; purine-containing compound salvage [GO:0043101]; purine nucleobase metabolic process [GO:0006144]; purine nucleotide catabolic process [GO:0006195]; response to drug [GO:0042493]; small molecule metabolic process [GO:0044281]; urate biosynthetic process [GO:0034418]	drug binding [GO:0008144]; nucleoside binding [GO:0001882]; phosphate ion binding [GO:0042301]; purine nucleobase binding [GO:0002060]; purine-nucleoside phosphorylase activity [GO:0004731]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular [GO:0005622]	GO:0034356; GO:0005737; GO:0005856; GO:0005829; GO:0008144; GO:0070062; GO:0006955; GO:0006148; GO:0070970; GO:0005622; GO:0006738; GO:0006139; GO:0055086; GO:0001882; GO:0042301; GO:0042102; GO:0046638; GO:0002060; GO:0006144; GO:0006195; GO:0043101; GO:0004731; GO:0042493; GO:0044281; GO:0034418	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:22509282}.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Disease mutation; Glycosyltransferase; Polymorphism; Reference proteome; Transferase	Beta strand (13); Chain (1); Helix (13); Modified residue (1); Natural variant (6); Turn (4)
LRRF1_HUMAN	Q32MZ4	LRRF1_HUMAN	reviewed	Leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1) (GC-binding factor 2) (TAR RNA-interacting protein)	LRRFIP1 GCF2 TRIP	Homo sapiens (Human)	808	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; protein homodimerization activity [GO:0042803]; innate immune response [GO:0045087]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of type I interferon production [GO:0032481]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]	innate immune response [GO:0045087]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of type I interferon production [GO:0032481]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]	DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0003677; GO:0005737; GO:0005856; GO:0005829; GO:0003725; GO:0045087; GO:0045892; GO:0005634; GO:0005886; GO:0032481; GO:0042803; GO:0006357; GO:0006351	SUBCELLULAR LOCATION: Nucleus. Cytoplasm.	3D-structure; Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; DNA-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repressor; Transcription; Transcription regulation	Alternative sequence (8); Chain (1); Coiled coil (1); Compositional bias (1); Erroneous gene model prediction (1); Helix (1); Initiator methionine (1); Modified residue (11); Natural variant (8); Region (1); Sequence caution (1); Sequence conflict (7); Turn (1)
TSSC4_HUMAN	Q9Y5U2	TSSC4_HUMAN	reviewed	Protein TSSC4 (Tumor-suppressing STF cDNA 4 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 4 protein)	TSSC4	Homo sapiens (Human)	329							Acetylation; Alternative splicing; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome	Alternative sequence (1); Chain (1); Modified residue (5); Natural variant (5); Sequence conflict (1)
B1AHC9_HUMAN	B1AHC9	B1AHC9_HUMAN	unreviewed	X-ray repair cross-complementing protein 6	XRCC6	Homo sapiens (Human)	559	Ku70:Ku80 complex [GO:0043564]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP-dependent DNA helicase activity [GO:0004003]; damaged DNA binding [GO:0003684]; telomeric DNA binding [GO:0042162]; double-strand break repair via nonhomologous end joining [GO:0006303]; telomere maintenance [GO:0000723]	double-strand break repair via nonhomologous end joining [GO:0006303]; telomere maintenance [GO:0000723]	ATP-dependent DNA helicase activity [GO:0004003]; damaged DNA binding [GO:0003684]; telomeric DNA binding [GO:0042162]	Ku70:Ku80 complex [GO:0043564]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0004003; GO:0043564; GO:0003684; GO:0006303; GO:0005654; GO:0005634; GO:0000723; GO:0042162		Complete proteome; Proteomics identification; Reference proteome	
DDX42_HUMAN	Q86XP3	DDX42_HUMAN	reviewed	ATP-dependent RNA helicase DDX42 (EC 3.6.4.13) (DEAD box protein 42) (RNA helicase-like protein) (RHELP) (RNA helicase-related protein) (RNAHP) (SF3b DEAD box protein) (Splicing factor 3B-associated 125 kDa protein) (SF3b125)	DDX42	Homo sapiens (Human)	938	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP-dependent RNA helicase activity [GO:0004004]; poly(A) RNA binding [GO:0044822]; protein localization [GO:0008104]; RNA secondary structure unwinding [GO:0010501]	protein localization [GO:0008104]; RNA secondary structure unwinding [GO:0010501]	ATP binding [GO:0005524]; ATP-dependent RNA helicase activity [GO:0004004]; poly(A) RNA binding [GO:0044822]	Cajal body [GO:0015030]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005524; GO:0004004; GO:0015030; GO:0010501; GO:0005737; GO:0016020; GO:0016607; GO:0005654; GO:0005634; GO:0044822; GO:0008104	SUBCELLULAR LOCATION: Cytoplasm. Nucleus speckle. Nucleus, Cajal body. Note=Isoform 2 is present in Cajal bodies (CBs) and nuclear speckles.	ATP-binding; Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Helicase; Hydrolase; Nucleotide-binding; Nucleus; Phosphoprotein; RNA-binding; Reference proteome	Alternative sequence (1); Chain (1); Coiled coil (1); Compositional bias (5); Domain (2); Frameshift (1); Modified residue (8); Motif (2); Nucleotide binding (1); Region (1)
PSA_HUMAN	P55786	PSA_HUMAN	reviewed	Puromycin-sensitive aminopeptidase (PSA) (EC 3.4.11.14) (Cytosol alanyl aminopeptidase) (AAP-S)	NPEPPS PSA	Homo sapiens (Human)	919	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; aminopeptidase activity [GO:0004177]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; cellular response to hypoxia [GO:0071456]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein polyubiquitination [GO:0000209]	antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; cellular response to hypoxia [GO:0071456]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein polyubiquitination [GO:0000209]	aminopeptidase activity [GO:0004177]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	GO:0004177; GO:0002474; GO:0071456; GO:0005829; GO:0070062; GO:0008237; GO:0005634; GO:1903955; GO:0000209; GO:0008270	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10978616}. Nucleus {ECO:0000305}.	Alternative splicing; Aminopeptidase; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Metal-binding; Metalloprotease; Nitration; Nucleus; Protease; Reference proteome; Zinc	Active site (1); Alternative sequence (2); Binding site (1); Chain (1); Erroneous initiation (2); Metal binding (3); Modified residue (1); Motif (1); Mutagenesis (4); Region (1); Sequence conflict (1); Site (1)
CAPZB_HUMAN	P47756	CAPZB_HUMAN	reviewed	F-actin-capping protein subunit beta (CapZ beta)	CAPZB	Homo sapiens (Human)	277	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; F-actin capping protein complex [GO:0008290]; sarcomere [GO:0030017]; WASH complex [GO:0071203]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; actin cytoskeleton organization [GO:0030036]; barbed-end actin filament capping [GO:0051016]; blood coagulation [GO:0007596]; cell morphogenesis [GO:0000902]; cytoskeleton organization [GO:0007010]; movement of cell or subcellular component [GO:0006928]; negative regulation of filopodium assembly [GO:0051490]; regulation of cell morphogenesis [GO:0022604]; regulation of lamellipodium assembly [GO:0010591]	actin cytoskeleton organization [GO:0030036]; barbed-end actin filament capping [GO:0051016]; blood coagulation [GO:0007596]; cell morphogenesis [GO:0000902]; cytoskeleton organization [GO:0007010]; movement of cell or subcellular component [GO:0006928]; negative regulation of filopodium assembly [GO:0051490]; regulation of cell morphogenesis [GO:0022604]; regulation of lamellipodium assembly [GO:0010591]	actin binding [GO:0003779]; actin filament binding [GO:0051015]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; F-actin capping protein complex [GO:0008290]; sarcomere [GO:0030017]; WASH complex [GO:0071203]	GO:0008290; GO:0071203; GO:0003779; GO:0015629; GO:0030036; GO:0005884; GO:0051015; GO:0051016; GO:0007596; GO:0000902; GO:0005856; GO:0007010; GO:0005829; GO:0070062; GO:0006928; GO:0051490; GO:0022604; GO:0010591; GO:0030017	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, myofibril, sarcomere {ECO:0000250}.	Acetylation; Actin capping; Actin-binding; Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Reference proteome	Alternative sequence (1); Chain (1); Initiator methionine (1); Modified residue (2)
TTL12_HUMAN	Q14166	TTL12_HUMAN	reviewed	Tubulin--tyrosine ligase-like protein 12	TTLL12 KIAA0153	Homo sapiens (Human)	644	cellular protein modification process [GO:0006464]	cellular protein modification process [GO:0006464]			GO:0006464		Complete proteome; Polymorphism; Reference proteome	Chain (1); Domain (1); Natural variant (4)
BOLA2_HUMAN	Q9H3K6	BOLA2_HUMAN	reviewed	BolA-like protein 2	BOLA2 BOLA2A My016; BOLA2B	Homo sapiens (Human)	86	extracellular exosome [GO:0070062]			extracellular exosome [GO:0070062]	GO:0070062		Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Reference proteome	Alternative sequence (2); Chain (1); Erroneous initiation (6); Modified residue (1)
E7EX90_HUMAN	E7EX90	E7EX90_HUMAN	unreviewed	Dynactin subunit 1	DCTN1	Homo sapiens (Human)	1256	dynactin complex [GO:0005869]; microtubule-based transport [GO:0010970]	microtubule-based transport [GO:0010970]		dynactin complex [GO:0005869]	GO:0005869; GO:0010970		Complete proteome; Proteomics identification; Reference proteome	
E9PQA1_HUMAN	E9PQA1	E9PQA1_HUMAN	unreviewed	Small acidic protein	C11orf58	Homo sapiens (Human)	86							Complete proteome; Proteomics identification; Reference proteome	
NSF1C_HUMAN	Q9UNZ2	NSF1C_HUMAN	reviewed	NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47)	NSFL1C UBXN2C	Homo sapiens (Human)	370	chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi stack [GO:0005795]; intermediate filament cytoskeleton [GO:0045111]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; VCP-NSFL1C complex [GO:1990730]; lipid binding [GO:0008289]; protein phosphatase type 1 regulator activity [GO:0008599]; ubiquitin binding [GO:0043130]; autophagic vacuole assembly [GO:0000045]; Golgi organization [GO:0007030]; membrane fusion [GO:0061025]; nuclear envelope reassembly [GO:0031468]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of catalytic activity [GO:0050790]	autophagic vacuole assembly [GO:0000045]; Golgi organization [GO:0007030]; membrane fusion [GO:0061025]; nuclear envelope reassembly [GO:0031468]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of catalytic activity [GO:0050790]	lipid binding [GO:0008289]; protein phosphatase type 1 regulator activity [GO:0008599]; ubiquitin binding [GO:0043130]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi stack [GO:0005795]; intermediate filament cytoskeleton [GO:0045111]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; VCP-NSFL1C complex [GO:1990730]	GO:0007030; GO:0005795; GO:1990730; GO:0000045; GO:0005694; GO:0005737; GO:0005829; GO:0045111; GO:0008289; GO:0061025; GO:0031468; GO:0005654; GO:0005634; GO:0005886; GO:0043161; GO:0008599; GO:0050790; GO:0043130	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Golgi apparatus, Golgi stack {ECO:0000250}. Chromosome {ECO:0000250}. Note=Predominantly nuclear in interphase cells. Bound to the axial elements of sex chromosomes in pachytene spermatocytes. A small proportion of the protein is cytoplasmic, associated with Golgi stacks (By similarity). {ECO:0000250}.	3D-structure; Alternative splicing; Chromosome; Complete proteome; Direct protein sequencing; Golgi apparatus; Lipid-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome	Alternative sequence (3); Beta strand (7); Chain (1); Compositional bias (1); Domain (2); Frameshift (1); Helix (3); Modified residue (5); Motif (2); Natural variant (1); Sequence caution (1); Sequence conflict (1); Turn (1)
NAMPT_HUMAN	P43490	NAMPT_HUMAN	reviewed	Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1) (Pre-B cell-enhancing factor) (Visfatin)	NAMPT PBEF PBEF1	Homo sapiens (Human)	491	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleus [GO:0005634]; cytokine activity [GO:0005125]; drug binding [GO:0008144]; nicotinamide phosphoribosyltransferase activity [GO:0047280]; nicotinate-nucleotide diphosphorylase (carboxylating) activity [GO:0004514]; cell-cell signaling [GO:0007267]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; female pregnancy [GO:0007565]; NAD biosynthetic process [GO:0009435]; NAD metabolic process [GO:0019674]; nicotinamide metabolic process [GO:0006769]; positive regulation of cell proliferation [GO:0008284]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; response to organic cyclic compound [GO:0014070]; signal transduction [GO:0007165]; small molecule metabolic process [GO:0044281]; vitamin metabolic process [GO:0006766]; water-soluble vitamin metabolic process [GO:0006767]	cell-cell signaling [GO:0007267]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; female pregnancy [GO:0007565]; NAD biosynthetic process [GO:0009435]; NAD metabolic process [GO:0019674]; nicotinamide metabolic process [GO:0006769]; positive regulation of cell proliferation [GO:0008284]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; response to organic cyclic compound [GO:0014070]; signal transduction [GO:0007165]; small molecule metabolic process [GO:0044281]; vitamin metabolic process [GO:0006766]; water-soluble vitamin metabolic process [GO:0006767]	cytokine activity [GO:0005125]; drug binding [GO:0008144]; nicotinamide phosphoribosyltransferase activity [GO:0047280]; nicotinate-nucleotide diphosphorylase (carboxylating) activity [GO:0004514]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleus [GO:0005634]	GO:0009435; GO:0019674; GO:0007267; GO:0032922; GO:0007623; GO:0005125; GO:0005829; GO:0008144; GO:0070062; GO:0005615; GO:0007565; GO:0006769; GO:0047280; GO:0004514; GO:0005634; GO:0008284; GO:0051770; GO:0048661; GO:0045944; GO:0014070; GO:0007165; GO:0044281; GO:0006766; GO:0006767	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24130902}. Cytoplasm {ECO:0000250|UniProtKB:Q99KQ4}. Secreted {ECO:0000269|PubMed:21741723}. Note=Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum. {ECO:0000269|PubMed:21741723, ECO:0000269|PubMed:24130902}.	3D-structure; Acetylation; Biological rhythms; Complete proteome; Cytokine; Cytoplasm; Glycosyltransferase; Nucleus; Phosphoprotein; Polymorphism; Pyridine nucleotide biosynthesis; Reference proteome; Secreted; Transferase	Beta strand (21); Binding site (6); Chain (1); Erroneous gene model prediction (2); Helix (26); Modified residue (2); Mutagenesis (3); Natural variant (1); Region (2); Turn (3)
E7EMW7_HUMAN	E7EMW7	E7EMW7_HUMAN	unreviewed	E3 ubiquitin-protein ligase UBR5	UBR5	Homo sapiens (Human)	2792	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; ligase activity [GO:0016874]; RNA binding [GO:0003723]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]	protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]	ligase activity [GO:0016874]; RNA binding [GO:0003723]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]	GO:0003723; GO:0005737; GO:0016874; GO:0005654; GO:0042787; GO:0004842; GO:0008270		Complete proteome; Ligase; Proteomics identification; Reference proteome; Ubl conjugation pathway	
UBR5_HUMAN	O95071	UBR5_HUMAN	reviewed	E3 ubiquitin-protein ligase UBR5 (EC 6.3.2.-) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)	UBR5 EDD EDD1 HYD KIAA0896	Homo sapiens (Human)	2799	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ligase activity [GO:0016874]; RNA binding [GO:0003723]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-ubiquitin ligase activity [GO:0034450]; zinc ion binding [GO:0008270]; cell proliferation [GO:0008283]; cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; negative regulation of double-strand break repair [GO:2000780]; negative regulation of histone H2A K63-linked ubiquitination [GO:1901315]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of catenin import into nucleus [GO:0035413]; positive regulation of protein import into nucleus, translocation [GO:0033160]; progesterone receptor signaling pathway [GO:0050847]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; ubiquitin-dependent protein catabolic process [GO:0006511]	cell proliferation [GO:0008283]; cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; negative regulation of double-strand break repair [GO:2000780]; negative regulation of histone H2A K63-linked ubiquitination [GO:1901315]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of catenin import into nucleus [GO:0035413]; positive regulation of protein import into nucleus, translocation [GO:0033160]; progesterone receptor signaling pathway [GO:0050847]; protein polyubiquitination [GO:0000209]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; ubiquitin-dependent protein catabolic process [GO:0006511]	ligase activity [GO:0016874]; RNA binding [GO:0003723]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-ubiquitin ligase activity [GO:0034450]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0006281; GO:0003723; GO:0008283; GO:0006974; GO:0005737; GO:0016874; GO:0016020; GO:2000780; GO:1901315; GO:0005654; GO:0005634; GO:0090263; GO:0035413; GO:0033160; GO:0050847; GO:0000209; GO:0042787; GO:0006511; GO:0004842; GO:0034450; GO:0008270	SUBCELLULAR LOCATION: Nucleus.	3D-structure; Acetylation; Alternative splicing; Complete proteome; DNA damage; DNA repair; Ligase; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation pathway; Zinc; Zinc-finger	Active site (1); Alternative sequence (1); Beta strand (4); Chain (1); Compositional bias (11); Domain (2); Erroneous initiation (1); Helix (13); Initiator methionine (1); Modified residue (32); Mutagenesis (1); Natural variant (1); Sequence conflict (11); Turn (2); Zinc finger (1)
NAA15_HUMAN	Q9BXJ9	NAA15_HUMAN	reviewed	N-alpha-acetyltransferase 15, NatA auxiliary subunit (Gastric cancer antigen Ga19) (N-terminal acetyltransferase) (NMDA receptor-regulated protein 1) (Protein tubedown-1) (Tbdn100)	NAA15 GA19 NARG1 NATH TBDN100	Homo sapiens (Human)	866	cytoplasm [GO:0005737]; membrane [GO:0016020]; NatA complex [GO:0031415]; nucleus [GO:0005634]; transcription factor complex [GO:0005667]; N-acetyltransferase activity [GO:0008080]; poly(A) RNA binding [GO:0044822]; ribosome binding [GO:0043022]; angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; N-terminal protein amino acid acetylation [GO:0006474]; negative regulation of apoptotic process [GO:0043066]; positive regulation of transcription, DNA-templated [GO:0045893]; protein stabilization [GO:0050821]; transcription, DNA-templated [GO:0006351]	angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; negative regulation of apoptotic process [GO:0043066]; N-terminal protein amino acid acetylation [GO:0006474]; positive regulation of transcription, DNA-templated [GO:0045893]; protein stabilization [GO:0050821]; transcription, DNA-templated [GO:0006351]	N-acetyltransferase activity [GO:0008080]; poly(A) RNA binding [GO:0044822]; ribosome binding [GO:0043022]	cytoplasm [GO:0005737]; membrane [GO:0016020]; NatA complex [GO:0031415]; nucleus [GO:0005634]; transcription factor complex [GO:0005667]	GO:0008080; GO:0006474; GO:0031415; GO:0001525; GO:0030154; GO:0005737; GO:0016020; GO:0043066; GO:0005634; GO:0044822; GO:0045893; GO:0050821; GO:0043022; GO:0005667; GO:0006351	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Mainly cytoplasmic, nuclear in some cases. Present in the free cytosolic and cytoskeleton-bound polysomes, but not in the membrane-bound polysomes.	Acetylation; Alternative splicing; Angiogenesis; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Nucleus; Phosphoprotein; Reference proteome; Repeat; TPR repeat; Transcription; Transcription regulation	Alternative sequence (2); Chain (1); Compositional bias (1); Modified residue (8); Motif (1); Region (1); Repeat (8); Sequence caution (1); Sequence conflict (1)
FTO_HUMAN	Q9C0B1	FTO_HUMAN	reviewed	Alpha-ketoglutarate-dependent dioxygenase FTO (EC 1.14.11.-) (Fat mass and obesity-associated protein)	FTO KIAA1752	Homo sapiens (Human)	505	nuclear speck [GO:0016607]; nucleus [GO:0005634]; DNA-N1-methyladenine dioxygenase activity [GO:0043734]; ferrous iron binding [GO:0008198]; oxidative DNA demethylase activity [GO:0035516]; oxidative RNA demethylase activity [GO:0035515]; adipose tissue development [GO:0060612]; DNA dealkylation involved in DNA repair [GO:0006307]; DNA demethylation [GO:0080111]; oxidative demethylation [GO:0070989]; oxidative single-stranded DNA demethylation [GO:0035552]; oxidative single-stranded RNA demethylation [GO:0035553]; regulation of lipid storage [GO:0010883]; regulation of multicellular organism growth [GO:0040014]; regulation of respiratory system process [GO:0044065]; regulation of white fat cell proliferation [GO:0070350]; RNA repair [GO:0042245]; temperature homeostasis [GO:0001659]	adipose tissue development [GO:0060612]; DNA dealkylation involved in DNA repair [GO:0006307]; DNA demethylation [GO:0080111]; oxidative demethylation [GO:0070989]; oxidative single-stranded DNA demethylation [GO:0035552]; oxidative single-stranded RNA demethylation [GO:0035553]; regulation of lipid storage [GO:0010883]; regulation of multicellular organism growth [GO:0040014]; regulation of respiratory system process [GO:0044065]; regulation of white fat cell proliferation [GO:0070350]; RNA repair [GO:0042245]; temperature homeostasis [GO:0001659]	DNA-N1-methyladenine dioxygenase activity [GO:0043734]; ferrous iron binding [GO:0008198]; oxidative DNA demethylase activity [GO:0035516]; oxidative RNA demethylase activity [GO:0035515]	nuclear speck [GO:0016607]; nucleus [GO:0005634]	GO:0006307; GO:0080111; GO:0043734; GO:0042245; GO:0060612; GO:0008198; GO:0016607; GO:0005634; GO:0035516; GO:0035515; GO:0070989; GO:0035552; GO:0035553; GO:0010883; GO:0040014; GO:0044065; GO:0070350; GO:0001659	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22002720}. Nucleus speckle {ECO:0000269|PubMed:22002720}.	3D-structure; Acetylation; Alternative splicing; Complete proteome; DNA damage; DNA repair; Dioxygenase; Disease mutation; Iron; Metal-binding; Nucleus; Obesity; Oxidoreductase; Polymorphism; RNA repair; Reference proteome	Alternative sequence (5); Beta strand (19); Binding site (6); Chain (1); Erroneous initiation (1); Helix (15); Metal binding (3); Modified residue (1); Mutagenesis (6); Natural variant (2); Region (4); Sequence conflict (4); Turn (3)
NAA10_HUMAN	P41227	NAA10_HUMAN	reviewed	N-alpha-acetyltransferase 10 (EC 2.3.1.-) (EC 2.3.1.88) (N-terminal acetyltransferase complex ARD1 subunit homolog A) (NatA catalytic subunit Naa10)	NAA10 ARD1 ARD1A TE2	Homo sapiens (Human)	235	cytoplasm [GO:0005737]; cytosolic ribosome [GO:0022626]; intracellular [GO:0005622]; membrane [GO:0016020]; NatA complex [GO:0031415]; nucleolus [GO:0005730]; nucleus [GO:0005634]; N-acetyltransferase activity [GO:0008080]; peptide-glutamate-N-acetyltransferase activity [GO:1990190]; peptide-serine-N-acetyltransferase activity [GO:1990189]; DNA packaging [GO:0006323]; internal protein amino acid acetylation [GO:0006475]; N-terminal peptidyl-glutamic acid acetylation [GO:0018002]; N-terminal peptidyl-serine acetylation [GO:0017198]; N-terminal protein amino acid acetylation [GO:0006474]	DNA packaging [GO:0006323]; internal protein amino acid acetylation [GO:0006475]; N-terminal peptidyl-glutamic acid acetylation [GO:0018002]; N-terminal peptidyl-serine acetylation [GO:0017198]; N-terminal protein amino acid acetylation [GO:0006474]	N-acetyltransferase activity [GO:0008080]; peptide-glutamate-N-acetyltransferase activity [GO:1990190]; peptide-serine-N-acetyltransferase activity [GO:1990189]	cytoplasm [GO:0005737]; cytosolic ribosome [GO:0022626]; intracellular [GO:0005622]; membrane [GO:0016020]; NatA complex [GO:0031415]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0006323; GO:0008080; GO:0018002; GO:0017198; GO:0006474; GO:0031415; GO:0005737; GO:0022626; GO:0006475; GO:0005622; GO:0016020; GO:0005730; GO:0005634; GO:1990190; GO:1990189	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=According to PubMed:12464182 it is cytoplasmic. According to PubMed:15496142, it is nuclear and cytoplasmic. Also present in the free cytosolic and cytoskeleton-bound polysomes.	Acetylation; Acyltransferase; Alternative splicing; Complete proteome; Cytoplasm; Disease mutation; Microphthalmia; Nucleus; Phosphoprotein; Reference proteome; Transferase	Alternative sequence (2); Chain (1); Domain (1); Modified residue (7); Mutagenesis (1); Natural variant (1); Region (1)
RL18A_HUMAN	Q02543	RL18A_HUMAN	reviewed	60S ribosomal protein L18a	RPL18A	Homo sapiens (Human)	176	cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; membrane [GO:0016020]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; membrane [GO:0016020]	GO:0003723; GO:0006614; GO:0044267; GO:0005829; GO:0022625; GO:0010467; GO:0016020; GO:0000184; GO:0044822; GO:0003735; GO:0006412; GO:0006414; GO:0006413; GO:0006415; GO:0019058; GO:0016032; GO:0019083		3D-structure; Complete proteome; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein	Chain (1); Frameshift (1); Modified residue (3); Sequence conflict (2)
OXSR1_HUMAN	O95747	OXSR1_HUMAN	reviewed	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein)	OXSR1 KIAA1101 OSR1	Homo sapiens (Human)	527	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine/threonine kinase activity [GO:0004674]; receptor signaling protein serine/threonine kinase activity [GO:0004702]; activation of protein kinase activity [GO:0032147]; cellular hypotonic response [GO:0071476]; intracellular signal transduction [GO:0035556]; negative regulation of potassium ion transmembrane transporter activity [GO:1901017]; negative regulation of rubidium ion transmembrane transporter activity [GO:2000687]; peptidyl-threonine phosphorylation [GO:0018107]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981]; regulation of mitotic cell cycle [GO:0007346]; response to oxidative stress [GO:0006979]; signal transduction by protein phosphorylation [GO:0023014]; stress-activated protein kinase signaling cascade [GO:0031098]	activation of protein kinase activity [GO:0032147]; cellular hypotonic response [GO:0071476]; intracellular signal transduction [GO:0035556]; negative regulation of potassium ion transmembrane transporter activity [GO:1901017]; negative regulation of rubidium ion transmembrane transporter activity [GO:2000687]; peptidyl-threonine phosphorylation [GO:0018107]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981]; regulation of mitotic cell cycle [GO:0007346]; response to oxidative stress [GO:0006979]; signal transduction by protein phosphorylation [GO:0023014]; stress-activated protein kinase signaling cascade [GO:0031098]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine/threonine kinase activity [GO:0004674]; receptor signaling protein serine/threonine kinase activity [GO:0004702]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]	GO:0005524; GO:0032147; GO:0071476; GO:0005737; GO:0070062; GO:0035556; GO:0000287; GO:1901017; GO:2000687; GO:0018107; GO:0006468; GO:0004674; GO:0004702; GO:0042981; GO:0007346; GO:0006979; GO:0023014; GO:0031098	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22361696}.	3D-structure; ATP-binding; Acetylation; Complete proteome; Cytoplasm; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase	Active site (1); Beta strand (12); Binding site (1); Chain (1); Domain (1); Erroneous initiation (1); Frameshift (1); Helix (20); Initiator methionine (1); Modified residue (4); Mutagenesis (2); Natural variant (3); Nucleotide binding (1); Sequence conflict (3); Turn (7)
SF3A3_HUMAN	Q12874	SF3A3_HUMAN	reviewed	Splicing factor 3A subunit 3 (SF3a60) (Spliceosome-associated protein 61) (SAP 61)	SF3A3 SAP61	Homo sapiens (Human)	501	catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; poly(A) RNA binding [GO:0044822]; zinc ion binding [GO:0008270]; gene expression [GO:0010467]; mRNA 3'-splice site recognition [GO:0000389]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]	gene expression [GO:0010467]; mRNA 3'-splice site recognition [GO:0000389]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]	poly(A) RNA binding [GO:0044822]; zinc ion binding [GO:0008270]	catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]	GO:0008380; GO:0000375; GO:0071013; GO:0010467; GO:0000389; GO:0006397; GO:0000398; GO:0016607; GO:0005654; GO:0044822; GO:0005681; GO:0008270	SUBCELLULAR LOCATION: Nucleus speckle.	3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Glycoprotein; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Spliceosome; Zinc; Zinc-finger; mRNA processing; mRNA splicing	Chain (1); Compositional bias (1); Glycosylation (1); Helix (1); Modified residue (5); Sequence conflict (1); Zinc finger (1)
PSMD1_HUMAN	Q99460	PSMD1_HUMAN	reviewed	26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (26S proteasome subunit p112)	PSMD1	Homo sapiens (Human)	953	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; enzyme regulator activity [GO:0030234]; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	enzyme regulator activity [GO:0030234]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]	GO:0006977; GO:0000082; GO:0031145; GO:0042590; GO:0002479; GO:0002474; GO:0006915; GO:0034641; GO:0005829; GO:0030234; GO:0070062; GO:0010467; GO:0045087; GO:0016020; GO:0000278; GO:0043066; GO:0090090; GO:0051436; GO:0005654; GO:0090263; GO:0051437; GO:0012501; GO:0022624; GO:0000502; GO:0005838; GO:0000209; GO:0042981; GO:0006521; GO:0051439; GO:0044281; GO:0002223; GO:0016032		Acetylation; Alternative splicing; Complete proteome; Phosphoprotein; Proteasome; Reference proteome; Repeat	Alternative sequence (1); Chain (1); Compositional bias (1); Modified residue (7); Repeat (10); Sequence caution (6); Sequence conflict (2)
ARPC2_HUMAN	O15144	ARPC2_HUMAN	reviewed	Actin-related protein 2/3 complex subunit 2 (Arp2/3 complex 34 kDa subunit) (p34-ARC)	ARPC2 ARC34 PRO2446	Homo sapiens (Human)	300	actin cytoskeleton [GO:0015629]; Arp2/3 protein complex [GO:0005885]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; synapse [GO:0045202]; structural constituent of cytoskeleton [GO:0005200]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; axon guidance [GO:0007411]; ephrin receptor signaling pathway [GO:0048013]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; innate immune response [GO:0045087]; movement of cell or subcellular component [GO:0006928]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; small GTPase mediated signal transduction [GO:0007264]	Arp2/3 complex-mediated actin nucleation [GO:0034314]; axon guidance [GO:0007411]; ephrin receptor signaling pathway [GO:0048013]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; innate immune response [GO:0045087]; movement of cell or subcellular component [GO:0006928]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; small GTPase mediated signal transduction [GO:0007264]	structural constituent of cytoskeleton [GO:0005200]	actin cytoskeleton [GO:0015629]; Arp2/3 protein complex [GO:0005885]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; synapse [GO:0045202]	GO:0034314; GO:0005885; GO:0038096; GO:0005794; GO:0015629; GO:0007411; GO:0031252; GO:0005737; GO:0005829; GO:0005768; GO:0048013; GO:0070062; GO:0005925; GO:0045087; GO:0006928; GO:0043005; GO:0005886; GO:0010592; GO:1900026; GO:0007264; GO:0005200; GO:0045202	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9230079}. Cell projection {ECO:0000269|PubMed:9230079}. Cell junction, synapse, synaptosome {ECO:0000250}.	Acetylation; Actin-binding; Cell junction; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Reference proteome; Synapse; Synaptosome	Chain (1); Erroneous initiation (1); Frameshift (1); Modified residue (2); Sequence conflict (2)
CLH1_HUMAN	Q00610	CLH1_HUMAN	reviewed	Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17)	CLTC CLH17 CLTCL2 KIAA0034	Homo sapiens (Human)	1675	clathrin coat [GO:0030118]; clathrin coat of coated pit [GO:0030132]; clathrin coat of trans-Golgi network vesicle [GO:0030130]; clathrin complex [GO:0071439]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein complex [GO:0043234]; spindle [GO:0005819]; trans-Golgi network membrane [GO:0032588]; clathrin light chain binding [GO:0032051]; double-stranded RNA binding [GO:0003725]; poly(A) RNA binding [GO:0044822]; protein kinase binding [GO:0019901]; structural molecule activity [GO:0005198]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; intracellular protein transport [GO:0006886]; membrane organization [GO:0061024]; mitotic nuclear division [GO:0007067]; negative regulation of hyaluronan biosynthetic process [GO:1900126]; negative regulation of protein localization to plasma membrane [GO:1903077]; osteoblast differentiation [GO:0001649]; post-Golgi vesicle-mediated transport [GO:0006892]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; transferrin transport [GO:0033572]	antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; intracellular protein transport [GO:0006886]; membrane organization [GO:0061024]; mitotic nuclear division [GO:0007067]; negative regulation of hyaluronan biosynthetic process [GO:1900126]; negative regulation of protein localization to plasma membrane [GO:1903077]; osteoblast differentiation [GO:0001649]; post-Golgi vesicle-mediated transport [GO:0006892]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; transferrin transport [GO:0033572]	clathrin light chain binding [GO:0032051]; double-stranded RNA binding [GO:0003725]; poly(A) RNA binding [GO:0044822]; protein kinase binding [GO:0019901]; structural molecule activity [GO:0005198]	clathrin coat [GO:0030118]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated vesicle [GO:0030136]; clathrin coat of coated pit [GO:0030132]; clathrin coat of trans-Golgi network vesicle [GO:0030130]; clathrin complex [GO:0071439]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; focal adhesion [GO:0005925]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein complex [GO:0043234]; spindle [GO:0005819]; trans-Golgi network membrane [GO:0032588]	GO:0019886; GO:0030118; GO:0030132; GO:0030130; GO:0071439; GO:0032051; GO:0030669; GO:0030136; GO:0005737; GO:0005829; GO:0003725; GO:0070062; GO:1903561; GO:0005925; GO:0043231; GO:0006886; GO:0042470; GO:0016020; GO:0061024; GO:0007067; GO:1900126; GO:1903077; GO:0001649; GO:0005886; GO:0044822; GO:0006892; GO:0043234; GO:0019901; GO:0031623; GO:0006898; GO:0005819; GO:0005198; GO:0032588; GO:0033572	SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:17081065}; Peripheral membrane protein {ECO:0000269|PubMed:17081065}; Cytoplasmic side {ECO:0000269|PubMed:17081065}. Membrane, coated pit {ECO:0000269|PubMed:17081065}; Peripheral membrane protein {ECO:0000269|PubMed:17081065}; Cytoplasmic side {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Cytoplasmic face of coated pits and vesicles. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.	3D-structure; Acetylation; Alternative splicing; Coated pit; Complete proteome; Cytoplasmic vesicle; Direct protein sequencing; Membrane; Phosphoprotein; Reference proteome; Repeat	Alternative sequence (2); Beta strand (27); Chain (1); Erroneous initiation (1); Helix (6); Initiator methionine (1); Modified residue (14); Region (15); Repeat (7); Sequence conflict (5); Turn (6)
HTSF1_HUMAN	O43719	HTSF1_HUMAN	reviewed	HIV Tat-specific factor 1 (Tat-SF1)	HTATSF1	Homo sapiens (Human)	755	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; regulation of DNA-templated transcription, elongation [GO:0032784]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]; viral genome replication [GO:0019079]	regulation of DNA-templated transcription, elongation [GO:0032784]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; transcription, DNA-templated [GO:0006351]; viral genome replication [GO:0019079]	nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005654; GO:0000166; GO:0005634; GO:0044822; GO:0032784; GO:0006357; GO:0006351; GO:0019079	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15485897, ECO:0000269|PubMed:8849451}.	3D-structure; Acetylation; Activator; Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein; Polymorphism; RNA-binding; Reference proteome; Repeat; Transcription; Transcription regulation	Beta strand (4); Chain (1); Compositional bias (2); Domain (2); Erroneous initiation (1); Frameshift (1); Helix (4); Initiator methionine (1); Modified residue (25); Mutagenesis (1); Natural variant (3); Region (1); Sequence conflict (2)
TFG_HUMAN	Q92734	TFG_HUMAN	reviewed	Protein TFG (TRK-fused gene protein)	TFG	Homo sapiens (Human)	400	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; signal transducer activity [GO:0004871]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; signal transduction [GO:0007165]	positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; signal transduction [GO:0007165]	signal transducer activity [GO:0004871]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]	GO:0005737; GO:0070062; GO:0043123; GO:0004871; GO:0007165		Acetylation; Alternative splicing; Chromosomal rearrangement; Coiled coil; Complete proteome; Direct protein sequencing; Disease mutation; Hereditary spastic paraplegia; Neurodegeneration; Neuropathy; Phosphoprotein; Polymorphism; Proto-oncogene; Reference proteome	Alternative sequence (3); Chain (1); Coiled coil (1); Domain (1); Modified residue (2); Natural variant (6); Sequence conflict (2); Site (1)
NUDC1_HUMAN	Q96RS6	NUDC1_HUMAN	reviewed	NudC domain-containing protein 1 (Chronic myelogenous leukemia tumor antigen 66) (Tumor antigen CML66)	NUDCD1 CML66	Homo sapiens (Human)	583	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; immune system process [GO:0002376]	immune system process [GO:0002376]		cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005737; GO:0002376; GO:0005654; GO:0005634	SUBCELLULAR LOCATION: Isoform 1: Cytoplasm. Nucleus.; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm.; SUBCELLULAR LOCATION: Isoform 3: Cytoplasm. Nucleus.	Alternative splicing; Complete proteome; Cytoplasm; Immunity; Nucleus; Polymorphism; Reference proteome; Tumor antigen	Alternative sequence (4); Chain (1); Domain (1); Natural variant (4); Sequence conflict (1)
E9PD53_HUMAN	E9PD53	E9PD53_HUMAN	unreviewed	Structural maintenance of chromosomes protein	SMC4	Homo sapiens (Human)	1263	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; chromosome organization [GO:0051276]	chromosome organization [GO:0051276]	ATP binding [GO:0005524]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]	GO:0005524; GO:0005694; GO:0051276; GO:0005737; GO:0005654	SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR005719}.	Complete proteome; Nucleus; Proteomics identification; Reference proteome	
SEC13_HUMAN	P55735	SEC13_HUMAN	reviewed	Protein SEC13 homolog (SEC13-like protein 1) (SEC13-related protein)	SEC13 D3S1231E SEC13L1 SEC13R	Homo sapiens (Human)	322	cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; nuclear envelope [GO:0005635]; nuclear pore outer ring [GO:0031080]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; cellular protein metabolic process [GO:0044267]; COPII vesicle coating [GO:0048208]; ER to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; membrane organization [GO:0061024]; mitotic cell cycle [GO:0000278]; mRNA transport [GO:0051028]; post-translational protein modification [GO:0043687]; protein N-linked glycosylation via asparagine [GO:0018279]; small GTPase mediated signal transduction [GO:0007264]	antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; cellular protein metabolic process [GO:0044267]; COPII vesicle coating [GO:0048208]; ER to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; membrane organization [GO:0061024]; mitotic cell cycle [GO:0000278]; mRNA transport [GO:0051028]; post-translational protein modification [GO:0043687]; protein N-linked glycosylation via asparagine [GO:0018279]; small GTPase mediated signal transduction [GO:0007264]		cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; nuclear envelope [GO:0005635]; nuclear pore outer ring [GO:0031080]	GO:0048208; GO:0012507; GO:0006888; GO:0000139; GO:0019886; GO:0002474; GO:0044267; GO:0005829; GO:0005789; GO:0070062; GO:0006886; GO:0051028; GO:0061024; GO:0000278; GO:0005635; GO:0031080; GO:0043687; GO:0018279; GO:0007264	SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex. Note=In interphase, localizes at both sides of the NPC.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasmic vesicle; Direct protein sequencing; ER-Golgi transport; Endoplasmic reticulum; Membrane; Nuclear pore complex; Nucleus; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Repeat; Translocation; Transport; WD repeat; mRNA transport	Alternative sequence (2); Beta strand (28); Chain (1); Erroneous initiation (1); Helix (2); Initiator methionine (1); Modified residue (2); Natural variant (1); Repeat (6); Sequence conflict (1); Turn (2)
ZC3HF_HUMAN	Q8WU90	ZC3HF_HUMAN	reviewed	Zinc finger CCCH domain-containing protein 15 (DRG family-regulatory protein 1) (Likely ortholog of mouse immediate early response erythropoietin 4)	ZC3H15 DFRP1 LEREPO4 HSPC303 HT010 MSTP012 PP730	Homo sapiens (Human)	426	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; metal ion binding [GO:0046872]; poly(A) RNA binding [GO:0044822]; cytokine-mediated signaling pathway [GO:0019221]	cytokine-mediated signaling pathway [GO:0019221]	metal ion binding [GO:0046872]; poly(A) RNA binding [GO:0044822]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]	GO:0019221; GO:0005737; GO:0046872; GO:0005730; GO:0044822	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15676025, ECO:0000269|PubMed:19819225}. Nucleus {ECO:0000250}. Note=The DRG1-DFRP2/ZC3H15 complex associates with polysomes.	Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Zinc; Zinc-finger	Alternative sequence (3); Chain (1); Coiled coil (2); Frameshift (4); Modified residue (2); Natural variant (2); Region (1); Sequence conflict (11); Zinc finger (2)
PDIA6_HUMAN	Q15084	PDIA6_HUMAN	reviewed	Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7)	PDIA6 ERP5 P5 TXNDC7	Homo sapiens (Human)	440	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum [GO:0005790]; protein disulfide isomerase activity [GO:0003756]; cell redox homeostasis [GO:0045454]; cellular protein metabolic process [GO:0044267]; endoplasmic reticulum unfolded protein response [GO:0030968]; IRE1-mediated unfolded protein response [GO:0036498]; protein folding [GO:0006457]; response to endoplasmic reticulum stress [GO:0034976]	cell redox homeostasis [GO:0045454]; cellular protein metabolic process [GO:0044267]; endoplasmic reticulum unfolded protein response [GO:0030968]; IRE1-mediated unfolded protein response [GO:0036498]; protein folding [GO:0006457]; response to endoplasmic reticulum stress [GO:0034976]	protein disulfide isomerase activity [GO:0003756]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum [GO:0005790]	GO:0036498; GO:0045454; GO:0044267; GO:0005783; GO:0034663; GO:0005788; GO:0005789; GO:0030968; GO:0005793; GO:0070062; GO:0042470; GO:0005886; GO:0003756; GO:0006457; GO:0034976; GO:0005790	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}. Cell membrane. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.	3D-structure; Alternative splicing; Cell membrane; Chaperone; Complete proteome; Direct protein sequencing; Disulfide bond; Endoplasmic reticulum; Isomerase; Membrane; Phosphoprotein; Polymorphism; Redox-active center; Reference proteome; Repeat; Signal	Active site (4); Alternative sequence (4); Beta strand (10); Chain (1); Compositional bias (1); Disulfide bond (2); Domain (2); Helix (9); Modified residue (2); Motif (1); Mutagenesis (4); Natural variant (1); Sequence conflict (2); Signal peptide (1); Site (6); Turn (6)
C9J286_HUMAN	C9J286	C9J286_HUMAN	unreviewed	Cleavage and polyadenylation-specificity factor subunit 7 (Fragment)	CPSF7	Homo sapiens (Human)	144	nucleic acid binding [GO:0003676]; nucleotide binding [GO:0000166]		nucleic acid binding [GO:0003676]; nucleotide binding [GO:0000166]		GO:0003676; GO:0000166		Complete proteome; Proteomics identification; Reference proteome	Non-terminal residue (1)
RS11_HUMAN	P62280	RS11_HUMAN	reviewed	40S ribosomal protein S11	RPS11	Homo sapiens (Human)	158	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; ribosome [GO:0005840]; poly(A) RNA binding [GO:0044822]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	poly(A) RNA binding [GO:0044822]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; ribosome [GO:0005840]	GO:0006614; GO:0044267; GO:0005737; GO:0005829; GO:0022627; GO:0070062; GO:0005925; GO:0010467; GO:0016020; GO:0000184; GO:0005730; GO:0044822; GO:0019843; GO:0005840; GO:0003735; GO:0006412; GO:0006414; GO:0006413; GO:0006415; GO:0019058; GO:0016032; GO:0019083		3D-structure; Acetylation; Citrullination; Complete proteome; Direct protein sequencing; Lipoprotein; Palmitate; RNA-binding; Reference proteome; Ribonucleoprotein; Ribosomal protein; rRNA-binding	Chain (1); Initiator methionine (1); Lipidation (1); Modified residue (5); Mutagenesis (1)
HNRPK_HUMAN	P61978	HNRPK_HUMAN	reviewed	Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP)	HNRNPK HNRPK	Homo sapiens (Human)	463	catalytic step 2 spliceosome [GO:0071013]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nuclear chromatin [GO:0000790]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; podosome [GO:0002102]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [GO:0001077]; single-stranded DNA binding [GO:0003697]; gene expression [GO:0010467]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of low-density lipoprotein particle receptor biosynthetic process [GO:0045716]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter [GO:0072369]; regulation of low-density lipoprotein particle clearance [GO:0010988]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]; signal transduction [GO:0007165]; viral process [GO:0016032]	gene expression [GO:0010467]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of low-density lipoprotein particle receptor biosynthetic process [GO:0045716]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter [GO:0072369]; regulation of low-density lipoprotein particle clearance [GO:0010988]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]; signal transduction [GO:0007165]; viral process [GO:0016032]	poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978]; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [GO:0001077]; single-stranded DNA binding [GO:0003697]	catalytic step 2 spliceosome [GO:0071013]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nuclear chromatin [GO:0000790]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; podosome [GO:0002102]	GO:0003723; GO:0000978; GO:0001077; GO:0006396; GO:0008380; GO:0071013; GO:0042995; GO:0005737; GO:0070062; GO:0005925; GO:0010467; GO:0000398; GO:0016020; GO:0000790; GO:0005654; GO:0005634; GO:0002102; GO:0044822; GO:0045716; GO:0048260; GO:0045944; GO:0072369; GO:0010988; GO:0007165; GO:0003697; GO:0016032	SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleoplasm. Cell projection, podosome. Note=Recruited to p53/TP53-responsive promoters, in the presence of functional p53/TP53. In case of ASFV infection, there is a shift in the localization which becomes predominantly nuclear.	3D-structure; Acetylation; Activator; Alternative splicing; Cell junction; Cell projection; Complete proteome; Cytoplasm; DNA-binding; Direct protein sequencing; Glycoprotein; Host-virus interaction; Isopeptide bond; Nucleus; Phosphoprotein; RNA-binding; Reference proteome; Repeat; Repressor; Ribonucleoprotein; Spliceosome; Transcription; Transcription regulation; Ubl conjugation; mRNA processing; mRNA splicing	Alternative sequence (2); Beta strand (3); Chain (1); Compositional bias (2); Cross-link (1); Domain (3); Erroneous initiation (1); Helix (5); Mass spectrometry (1); Modified residue (9); Mutagenesis (2); Region (7); Repeat (9); Sequence conflict (1); Turn (1)
PRDX3_HUMAN	P30048	PRDX3_HUMAN	reviewed	Thioredoxin-dependent peroxide reductase, mitochondrial (EC 1.11.1.15) (Antioxidant protein 1) (AOP-1) (HBC189) (Peroxiredoxin III) (Prx-III) (Peroxiredoxin-3) (Protein MER5 homolog)	PRDX3 AOP1	Homo sapiens (Human)	256	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; alkyl hydroperoxide reductase activity [GO:0008785]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; kinase binding [GO:0019900]; protein C-terminus binding [GO:0008022]; protein kinase binding [GO:0019901]; thioredoxin peroxidase activity [GO:0008379]; apoptotic process [GO:0006915]; cellular response to oxidative stress [GO:0034599]; cellular response to reactive oxygen species [GO:0034614]; hydrogen peroxide catabolic process [GO:0042744]; maternal placenta development [GO:0001893]; mitochondrion organization [GO:0007005]; myeloid cell differentiation [GO:0030099]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of kinase activity [GO:0033673]; peptidyl-cysteine oxidation [GO:0018171]; positive regulation of cell proliferation [GO:0008284]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; regulation of mitochondrial membrane potential [GO:0051881]; response to hydrogen peroxide [GO:0042542]; response to lipopolysaccharide [GO:0032496]; response to oxidative stress [GO:0006979]; response to reactive oxygen species [GO:0000302]	apoptotic process [GO:0006915]; cellular response to oxidative stress [GO:0034599]; cellular response to reactive oxygen species [GO:0034614]; hydrogen peroxide catabolic process [GO:0042744]; maternal placenta development [GO:0001893]; mitochondrion organization [GO:0007005]; myeloid cell differentiation [GO:0030099]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of kinase activity [GO:0033673]; peptidyl-cysteine oxidation [GO:0018171]; positive regulation of cell proliferation [GO:0008284]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; regulation of mitochondrial membrane potential [GO:0051881]; response to hydrogen peroxide [GO:0042542]; response to lipopolysaccharide [GO:0032496]; response to oxidative stress [GO:0006979]; response to reactive oxygen species [GO:0000302]	alkyl hydroperoxide reductase activity [GO:0008785]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; kinase binding [GO:0019900]; protein C-terminus binding [GO:0008022]; protein kinase binding [GO:0019901]; thioredoxin peroxidase activity [GO:0008379]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0008785; GO:0006915; GO:0034599; GO:0034614; GO:0043027; GO:0005737; GO:0005829; GO:0005769; GO:0070062; GO:0042744; GO:0019900; GO:0001893; GO:0005759; GO:0005739; GO:0007005; GO:0030099; GO:0043066; GO:0043154; GO:0033673; GO:0018171; GO:0051092; GO:0008284; GO:0008022; GO:0019901; GO:0051881; GO:0042542; GO:0032496; GO:0006979; GO:0000302; GO:0008379	SUBCELLULAR LOCATION: Mitochondrion.	Acetylation; Alternative splicing; Antioxidant; Complete proteome; Direct protein sequencing; Disulfide bond; Mitochondrion; Oxidoreductase; Peroxidase; Phosphoprotein; Polymorphism; Redox-active center; Reference proteome; Transit peptide	Active site (1); Alternative sequence (1); Chain (1); Disulfide bond (2); Domain (1); Modified residue (4); Mutagenesis (1); Natural variant (4); Sequence conflict (1); Transit peptide (1)
WDR1_HUMAN	O75083	WDR1_HUMAN	reviewed	WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1)	WDR1	Homo sapiens (Human)	606	actin filament [GO:0005884]; cell junction [GO:0030054]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; podosome [GO:0002102]; blood coagulation [GO:0007596]; platelet activation [GO:0030168]; platelet degranulation [GO:0002576]; regulation of oligodendrocyte differentiation [GO:0048713]; sensory perception of sound [GO:0007605]	blood coagulation [GO:0007596]; platelet activation [GO:0030168]; platelet degranulation [GO:0002576]; regulation of oligodendrocyte differentiation [GO:0048713]; sensory perception of sound [GO:0007605]		actin filament [GO:0005884]; cell junction [GO:0030054]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; podosome [GO:0002102]	GO:0005884; GO:0007596; GO:0030054; GO:0042995; GO:0005737; GO:0005829; GO:0070062; GO:0005576; GO:0030168; GO:0002576; GO:0002102; GO:0048713; GO:0007605	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, podosome {ECO:0000269|PubMed:22721921}.	Acetylation; Actin-binding; Alternative splicing; Cell junction; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Phosphoprotein; Polymorphism; Reference proteome; Repeat; WD repeat	Alternative sequence (1); Chain (1); Initiator methionine (1); Modified residue (6); Natural variant (1); Repeat (11); Sequence caution (1)
F120A_HUMAN	Q9NZB2	F120A_HUMAN	reviewed	Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated Src activator) (Protein FAM120A)	FAM120A C9orf10 KIAA0183 OSSA	Homo sapiens (Human)	1118	cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]; poly(A) RNA binding [GO:0044822]		poly(A) RNA binding [GO:0044822]	cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005737; GO:0016020; GO:0005886; GO:0044822	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19015244}. Cell membrane {ECO:0000269|PubMed:19015244}; Peripheral membrane protein {ECO:0000269|PubMed:19015244}; Cytoplasmic side {ECO:0000269|PubMed:19015244}. Note=Translocates to plasma membrane upon ultraviolet exposure.	Acetylation; Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Membrane; Phosphoprotein; Polymorphism; RNA-binding; Reference proteome; Tumor suppressor	Alternative sequence (6); Chain (1); Frameshift (1); Modified residue (6); Natural variant (1); Region (2); Sequence conflict (2)
EIF3A_HUMAN	Q14152	EIF3A_HUMAN	reviewed	Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) (eIF3 p167) (eIF3 p180) (eIF3 p185)	EIF3A EIF3S10 KIAA0139	Homo sapiens (Human)	1382	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; poly(A) RNA binding [GO:0044822]; structural molecule activity [GO:0005198]; translation initiation factor activity [GO:0003743]; cellular protein metabolic process [GO:0044267]; formation of cytoplasmic translation initiation complex [GO:0001732]; formation of translation preinitiation complex [GO:0001731]; gene expression [GO:0010467]; regulation of translational initiation [GO:0006446]; translation [GO:0006412]; translational initiation [GO:0006413]	cellular protein metabolic process [GO:0044267]; formation of cytoplasmic translation initiation complex [GO:0001732]; formation of translation preinitiation complex [GO:0001731]; gene expression [GO:0010467]; regulation of translational initiation [GO:0006446]; translation [GO:0006412]; translational initiation [GO:0006413]	poly(A) RNA binding [GO:0044822]; structural molecule activity [GO:0005198]; translation initiation factor activity [GO:0003743]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0044267; GO:0005737; GO:0005829; GO:0016282; GO:0033290; GO:0005852; GO:0071541; GO:0001732; GO:0001731; GO:0010467; GO:0016020; GO:0005730; GO:0005634; GO:0044822; GO:0006446; GO:0005198; GO:0006412; GO:0003743; GO:0006413	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03000, ECO:0000269|PubMed:9150439}.	3D-structure; Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Initiation factor; Phosphoprotein; Polymorphism; Protein biosynthesis; Reference proteome; Repeat	Alternative sequence (1); Chain (1); Coiled coil (1); Compositional bias (2); Domain (1); Erroneous initiation (1); Initiator methionine (1); Mass spectrometry (1); Modified residue (7); Natural variant (3); Region (2); Repeat (25); Sequence conflict (3)
C1QBP_HUMAN	Q07021	C1QBP_HUMAN	reviewed	Complement component 1 Q subcomponent-binding protein, mitochondrial (ASF/SF2-associated protein p32) (Glycoprotein gC1qBP) (C1qBP) (Hyaluronan-binding protein 1) (Mitochondrial matrix protein p32) (gC1q-R protein) (p33)	C1QBP GC1QBP HABP1 SF2P32	Homo sapiens (Human)	282	cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; adrenergic receptor binding [GO:0031690]; complement component C1q binding [GO:0001849]; hyaluronic acid binding [GO:0005540]; kininogen binding [GO:0030984]; mitochondrial ribosome binding [GO:0097177]; mRNA binding [GO:0003729]; transcription corepressor activity [GO:0003714]; transcription factor binding [GO:0008134]; apoptotic process [GO:0006915]; blood coagulation [GO:0007596]; blood coagulation, intrinsic pathway [GO:0007597]; complement activation, classical pathway [GO:0006958]; immune response [GO:0006955]; innate immune response [GO:0045087]; mature ribosome assembly [GO:0042256]; mRNA processing [GO:0006397]; negative regulation of defense response to virus [GO:0050687]; negative regulation of interferon-gamma production [GO:0032689]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of MDA-5 signaling pathway [GO:0039534]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of RIG-I signaling pathway [GO:0039536]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; phosphatidylinositol 3-kinase signaling [GO:0014065]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell adhesion [GO:0045785]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of mitochondrial translation [GO:0070131]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of trophoblast cell migration [GO:1901165]; regulation of complement activation [GO:0030449]; RNA splicing [GO:0008380]; transcription, DNA-templated [GO:0006351]; viral process [GO:0016032]	apoptotic process [GO:0006915]; blood coagulation [GO:0007596]; blood coagulation, intrinsic pathway [GO:0007597]; complement activation, classical pathway [GO:0006958]; immune response [GO:0006955]; innate immune response [GO:0045087]; mature ribosome assembly [GO:0042256]; mRNA processing [GO:0006397]; negative regulation of defense response to virus [GO:0050687]; negative regulation of interferon-gamma production [GO:0032689]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of MDA-5 signaling pathway [GO:0039534]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of RIG-I signaling pathway [GO:0039536]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; phosphatidylinositol 3-kinase signaling [GO:0014065]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell adhesion [GO:0045785]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of mitochondrial translation [GO:0070131]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; positive regulation of trophoblast cell migration [GO:1901165]; regulation of complement activation [GO:0030449]; RNA splicing [GO:0008380]; transcription, DNA-templated [GO:0006351]; viral process [GO:0016032]	adrenergic receptor binding [GO:0031690]; complement component C1q binding [GO:0001849]; hyaluronic acid binding [GO:0005540]; kininogen binding [GO:0030984]; mitochondrial ribosome binding [GO:0097177]; mRNA binding [GO:0003729]; transcription corepressor activity [GO:0003714]; transcription factor binding [GO:0008134]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0008380; GO:0031690; GO:0006915; GO:0007596; GO:0007597; GO:0009986; GO:0006958; GO:0001849; GO:0005737; GO:0005829; GO:0005615; GO:0005540; GO:0006955; GO:0045087; GO:0030984; GO:0003729; GO:0006397; GO:0042256; GO:0016020; GO:0005759; GO:0097177; GO:0005739; GO:0039534; GO:0039536; GO:0050687; GO:0032689; GO:0032695; GO:0048025; GO:0000122; GO:0005730; GO:0005634; GO:0014065; GO:0005886; GO:0043065; GO:0045785; GO:2000510; GO:0070131; GO:0090023; GO:0051897; GO:1900026; GO:1901165; GO:0030449; GO:0003714; GO:0008134; GO:0006351; GO:0016032	SUBCELLULAR LOCATION: Mitochondrion matrix. Nucleus. Cell membrane; Peripheral membrane protein; Extracellular side. Secreted. Cytoplasm. Nucleus, nucleolus. Note=Seems to be predominantly localized to mitochondria. Secreted by activated lymphocytes.	3D-structure; Acetylation; Adaptive immunity; Apoptosis; Cell membrane; Complement pathway; Complete proteome; Cytoplasm; Direct protein sequencing; Host-virus interaction; Immunity; Innate immunity; Membrane; Mitochondrion; Nucleus; Phosphoprotein; Reference proteome; Ribosome biogenesis; Secreted; Transcription; Transcription regulation; Transit peptide; mRNA processing; mRNA splicing	Beta strand (7); Chain (1); Helix (4); Modified residue (5); Mutagenesis (1); Region (2); Transit peptide (1); Turn (2)
RENT1_HUMAN	Q92900	RENT1_HUMAN	reviewed	Regulator of nonsense transcripts 1 (EC 3.6.4.-) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) (hUpf1)	UPF1 KIAA0221 RENT1	Homo sapiens (Human)	1129	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytoplasmic mRNA processing body [GO:0000932]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; supraspliceosomal complex [GO:0044530]; ATP binding [GO:0005524]; ATP-dependent RNA helicase activity [GO:0004004]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; dosage compensation by inactivation of X chromosome [GO:0009048]; gene expression [GO:0010467]; histone mRNA catabolic process [GO:0071044]; mRNA export from nucleus [GO:0006406]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of translational termination [GO:0006449]	DNA repair [GO:0006281]; DNA replication [GO:0006260]; dosage compensation by inactivation of X chromosome [GO:0009048]; gene expression [GO:0010467]; histone mRNA catabolic process [GO:0071044]; mRNA export from nucleus [GO:0006406]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of translational termination [GO:0006449]	ATP binding [GO:0005524]; ATP-dependent RNA helicase activity [GO:0004004]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytoplasmic mRNA processing body [GO:0000932]; cytosol [GO:0005829]; exon-exon junction complex [GO:0035145]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; supraspliceosomal complex [GO:0044530]	GO:0005524; GO:0004004; GO:0003677; GO:0006281; GO:0006260; GO:0003723; GO:0000785; GO:0003682; GO:0005737; GO:0000932; GO:0005829; GO:0009048; GO:0035145; GO:0010467; GO:0004386; GO:0071044; GO:0006406; GO:0000956; GO:0000184; GO:0005654; GO:0005634; GO:0044822; GO:0006449; GO:0044530; GO:0008270	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, P-body. Nucleus. Note=Hyperphosphorylated form is targeted to the P-body, while unphosphorylated protein is distributed throughout the cytoplasm.	3D-structure; ATP-binding; Alternative splicing; Complete proteome; Cytoplasm; Helicase; Hydrolase; Metal-binding; Nonsense-mediated mRNA decay; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; RNA-binding; Reference proteome; Repeat; Zinc; Zinc-finger	Alternative sequence (1); Beta strand (39); Binding site (4); Chain (1); Compositional bias (2); Erroneous initiation (1); Helix (34); Modified residue (6); Motif (2); Mutagenesis (18); Natural variant (1); Nucleotide binding (1); Region (1); Sequence conflict (6); Turn (13); Zinc finger (1)
NHRF1_HUMAN	O14745	NHRF1_HUMAN	reviewed	Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1)	SLC9A3R1 NHERF NHERF1	Homo sapiens (Human)	358	actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; cell periphery [GO:0071944]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; membrane raft [GO:0045121]; microvillus [GO:0005902]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; sperm midpiece [GO:0097225]; vesicle [GO:0031982]; beta-2 adrenergic receptor binding [GO:0031698]; beta-catenin binding [GO:0008013]; chloride channel regulator activity [GO:0017081]; growth factor receptor binding [GO:0070851]; PDZ domain binding [GO:0030165]; phosphatase binding [GO:0019902]; protein self-association [GO:0043621]; receptor binding [GO:0005102]; actin cytoskeleton organization [GO:0030036]; adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; bile acid secretion [GO:0032782]; cellular phosphate ion homeostasis [GO:0030643]; cellular protein localization [GO:0034613]; glutathione transport [GO:0034635]; microvillus assembly [GO:0030033]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of phosphatidylinositol 3-kinase signaling [GO:0014067]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of protein kinase B signaling [GO:0051898]; negative regulation of sodium:proton antiporter activity [GO:0032416]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; protein complex assembly [GO:0006461]; regulation of excretion [GO:0044062]; regulation of protein kinase activity [GO:0045859]; regulation of sodium:proton antiporter activity [GO:0032415]; renal absorption [GO:0070293]; renal phosphate ion absorption [GO:0097291]; renal sodium ion transport [GO:0003096]; Wnt signaling pathway [GO:0016055]	actin cytoskeleton organization [GO:0030036]; adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; bile acid secretion [GO:0032782]; cellular phosphate ion homeostasis [GO:0030643]; cellular protein localization [GO:0034613]; glutathione transport [GO:0034635]; microvillus assembly [GO:0030033]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of phosphatidylinositol 3-kinase signaling [GO:0014067]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of protein kinase B signaling [GO:0051898]; negative regulation of sodium:proton antiporter activity [GO:0032416]; phospholipase C-activating dopamine receptor signaling pathway [GO:0060158]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; protein complex assembly [GO:0006461]; regulation of excretion [GO:0044062]; regulation of protein kinase activity [GO:0045859]; regulation of sodium:proton antiporter activity [GO:0032415]; renal absorption [GO:0070293]; renal phosphate ion absorption [GO:0097291]; renal sodium ion transport [GO:0003096]; Wnt signaling pathway [GO:0016055]	beta-2 adrenergic receptor binding [GO:0031698]; beta-catenin binding [GO:0008013]; chloride channel regulator activity [GO:0017081]; growth factor receptor binding [GO:0070851]; PDZ domain binding [GO:0030165]; phosphatase binding [GO:0019902]; protein self-association [GO:0043621]; receptor binding [GO:0005102]	actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; cell periphery [GO:0071944]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; membrane raft [GO:0045121]; microvillus [GO:0005902]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; sperm midpiece [GO:0097225]; vesicle [GO:0031982]	GO:0030165; GO:0016055; GO:0015629; GO:0030036; GO:0007191; GO:0016324; GO:0031698; GO:0008013; GO:0032782; GO:0031526; GO:0071944; GO:0030643; GO:0034613; GO:0005813; GO:0017081; GO:0005737; GO:0012505; GO:0070062; GO:0030175; GO:0034635; GO:0070851; GO:0043231; GO:0016020; GO:0045121; GO:0005902; GO:0030033; GO:0031528; GO:0070373; GO:0030336; GO:0008285; GO:0014067; GO:0010642; GO:0051898; GO:0032416; GO:0019902; GO:0060158; GO:0005886; GO:2001244; GO:0006461; GO:0043621; GO:0005102; GO:0044062; GO:0045859; GO:0032415; GO:0070293; GO:0097291; GO:0003096; GO:0001726; GO:0097225; GO:0031982	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Apical cell membrane {ECO:0000250}. Endomembrane system; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Cell projection, microvillus. Note=Translocates from the cytoplasm to the apical cell membrane in a PODXL-dependent manner. Colocalizes with CFTR at the midpiece of sperm tail (By similarity). Colocalizes with actin in microvilli-rich apical regions of the syncytiotrophoblast. Found in microvilli, ruffling membrane and filopodia of HeLa cells. Present in lipid rafts of T-cells. {ECO:0000250}.	3D-structure; Acetylation; Alternative splicing; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Wnt signaling pathway	Alternative sequence (1); Beta strand (16); Chain (1); Domain (2); Erroneous initiation (1); Helix (11); Initiator methionine (1); Modified residue (10); Mutagenesis (2); Natural variant (4); Turn (5)
DNJB1_HUMAN	P25685	DNJB1_HUMAN	reviewed	DnaJ homolog subfamily B member 1 (DnaJ protein homolog 1) (Heat shock 40 kDa protein 1) (HSP40) (Heat shock protein 40) (Human DnaJ protein 1) (hDj-1)	DNAJB1 DNAJ1 HDJ1 HSPF1	Homo sapiens (Human)	340	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATPase activator activity [GO:0001671]; ATPase binding [GO:0051117]; chaperone binding [GO:0051087]; Hsp70 protein binding [GO:0030544]; unfolded protein binding [GO:0051082]; cellular response to heat [GO:0034605]; chaperone cofactor-dependent protein refolding [GO:0070389]; chaperone mediated protein folding requiring cofactor [GO:0051085]; negative regulation of inclusion body assembly [GO:0090084]; positive regulation of ATPase activity [GO:0032781]; regulation of cellular response to heat [GO:1900034]; response to unfolded protein [GO:0006986]	cellular response to heat [GO:0034605]; chaperone cofactor-dependent protein refolding [GO:0070389]; chaperone mediated protein folding requiring cofactor [GO:0051085]; negative regulation of inclusion body assembly [GO:0090084]; positive regulation of ATPase activity [GO:0032781]; regulation of cellular response to heat [GO:1900034]; response to unfolded protein [GO:0006986]	ATPase activator activity [GO:0001671]; ATPase binding [GO:0051117]; chaperone binding [GO:0051087]; Hsp70 protein binding [GO:0030544]; unfolded protein binding [GO:0051082]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0001671; GO:0051117; GO:0030544; GO:0034605; GO:0051087; GO:0070389; GO:0051085; GO:0005829; GO:0070062; GO:0090084; GO:0005730; GO:0005654; GO:0005634; GO:0032781; GO:1900034; GO:0006986; GO:0051082	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:1586970}. Nucleus {ECO:0000269|PubMed:1586970}. Nucleus, nucleolus {ECO:0000269|PubMed:1586970}. Note=Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock.	3D-structure; Alternative splicing; Chaperone; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Reference proteome; Stress response	Alternative sequence (1); Beta strand (13); Chain (1); Domain (1); Frameshift (1); Helix (7); Initiator methionine (1); Sequence conflict (4); Turn (2)
DLDH_HUMAN	P09622	DLDH_HUMAN	reviewed	Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein)	DLD GCSL LAD PHE3	Homo sapiens (Human)	509	acrosomal matrix [GO:0043159]; cilium [GO:0005929]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; dihydrolipoyl dehydrogenase activity [GO:0004148]; flavin adenine dinucleotide binding [GO:0050660]; branched-chain amino acid catabolic process [GO:0009083]; cell redox homeostasis [GO:0045454]; cellular metabolic process [GO:0044237]; cellular nitrogen compound metabolic process [GO:0034641]; gastrulation [GO:0007369]; lysine catabolic process [GO:0006554]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; proteolysis [GO:0006508]; pyruvate metabolic process [GO:0006090]; regulation of acetyl-CoA biosynthetic process from pyruvate [GO:0010510]; regulation of membrane potential [GO:0042391]; small molecule metabolic process [GO:0044281]; sperm capacitation [GO:0048240]; tricarboxylic acid cycle [GO:0006099]	branched-chain amino acid catabolic process [GO:0009083]; cell redox homeostasis [GO:0045454]; cellular metabolic process [GO:0044237]; cellular nitrogen compound metabolic process [GO:0034641]; gastrulation [GO:0007369]; lysine catabolic process [GO:0006554]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; proteolysis [GO:0006508]; pyruvate metabolic process [GO:0006090]; regulation of acetyl-CoA biosynthetic process from pyruvate [GO:0010510]; regulation of membrane potential [GO:0042391]; small molecule metabolic process [GO:0044281]; sperm capacitation [GO:0048240]; tricarboxylic acid cycle [GO:0006099]	dihydrolipoyl dehydrogenase activity [GO:0004148]; flavin adenine dinucleotide binding [GO:0050660]	acrosomal matrix [GO:0043159]; cilium [GO:0005929]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	GO:0043159; GO:0009083; GO:0045454; GO:0044237; GO:0034641; GO:0005929; GO:0004148; GO:0050660; GO:0007369; GO:0006554; GO:0006120; GO:0005759; GO:0005739; GO:0005654; GO:0006508; GO:0006090; GO:0010510; GO:0042391; GO:0044281; GO:0048240; GO:0006099	SUBCELLULAR LOCATION: Mitochondrion matrix.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Disease mutation; Disulfide bond; FAD; Flavoprotein; Mitochondrion; NAD; Oxidoreductase; Phosphoprotein; Polymorphism; Redox-active center; Reference proteome; Transit peptide	Active site (1); Alternative sequence (2); Beta strand (25); Binding site (6); Chain (1); Disulfide bond (1); Erroneous initiation (1); Helix (18); Modified residue (22); Natural variant (6); Nucleotide binding (4); Sequence conflict (3); Transit peptide (1); Turn (1)
EEA1_HUMAN	Q15075	EEA1_HUMAN	reviewed	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2)	EEA1 ZFYVE2	Homo sapiens (Human)	1411	axonal spine [GO:0044308]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]; extrinsic component of plasma membrane [GO:0019897]; membrane [GO:0016020]; recycling endosome [GO:0055037]; serine-pyruvate aminotransferase complex [GO:0005969]; 1-phosphatidylinositol binding [GO:0005545]; calmodulin binding [GO:0005516]; GTP-dependent protein binding [GO:0030742]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]; early endosome to late endosome transport [GO:0045022]; endocytosis [GO:0006897]; synaptic vesicle to endosome fusion [GO:0016189]; vesicle fusion [GO:0006906]	early endosome to late endosome transport [GO:0045022]; endocytosis [GO:0006897]; synaptic vesicle to endosome fusion [GO:0016189]; vesicle fusion [GO:0006906]	1-phosphatidylinositol binding [GO:0005545]; calmodulin binding [GO:0005516]; GTP-dependent protein binding [GO:0030742]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]	axonal spine [GO:0044308]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]; extrinsic component of plasma membrane [GO:0019897]; membrane [GO:0016020]; recycling endosome [GO:0055037]; serine-pyruvate aminotransferase complex [GO:0005969]	GO:0005545; GO:0030742; GO:0044308; GO:0005516; GO:0005737; GO:0031410; GO:0005829; GO:0005769; GO:0031901; GO:0045022; GO:0006897; GO:0070062; GO:0019897; GO:0016020; GO:0042803; GO:0055037; GO:0005969; GO:0016189; GO:0006906; GO:0008270	SUBCELLULAR LOCATION: Cytoplasm. Early endosome membrane; Peripheral membrane protein.	3D-structure; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Endosome; Membrane; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Zinc; Zinc-finger	Beta strand (8); Chain (1); Coiled coil (1); Compositional bias (3); Helix (6); Modified residue (1); Mutagenesis (23); Natural variant (1); Sequence conflict (9); Turn (4); Zinc finger (2)
DDB1_HUMAN	Q16531	DDB1_HUMAN	reviewed	DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe)	DDB1 XAP1	Homo sapiens (Human)	1140	Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; Cul4B-RING E3 ubiquitin ligase complex [GO:0031465]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA damage response, detection of DNA damage [GO:0042769]; DNA repair [GO:0006281]; histone H2A monoubiquitination [GO:0035518]; interaction with symbiont [GO:0051702]; negative regulation of apoptotic process [GO:0043066]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair, DNA damage removal [GO:0000718]; positive regulation by virus of viral protein levels in host cell [GO:0046726]; positive regulation of viral genome replication [GO:0045070]; positive regulation of viral release from host cell [GO:1902188]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of mitotic cell cycle phase transition [GO:1901990]; translesion synthesis [GO:0019985]; UV-damage excision repair [GO:0070914]; viral process [GO:0016032]; Wnt signaling pathway [GO:0016055]	DNA damage response, detection of DNA damage [GO:0042769]; DNA repair [GO:0006281]; histone H2A monoubiquitination [GO:0035518]; interaction with symbiont [GO:0051702]; negative regulation of apoptotic process [GO:0043066]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair, DNA damage removal [GO:0000718]; positive regulation by virus of viral protein levels in host cell [GO:0046726]; positive regulation of viral genome replication [GO:0045070]; positive regulation of viral release from host cell [GO:1902188]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of mitotic cell cycle phase transition [GO:1901990]; translesion synthesis [GO:0019985]; UV-damage excision repair [GO:0070914]; viral process [GO:0016032]; Wnt signaling pathway [GO:0016055]	damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]	Cul4A-RING E3 ubiquitin ligase complex [GO:0031464]; Cul4B-RING E3 ubiquitin ligase complex [GO:0031465]; Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0080008; GO:0031464; GO:0031465; GO:0003677; GO:0042769; GO:0006281; GO:0070914; GO:0016055; GO:0005737; GO:0003684; GO:0070062; GO:0005615; GO:0035518; GO:0051702; GO:0043066; GO:0005654; GO:0006289; GO:0000718; GO:0005634; GO:0046726; GO:0045070; GO:1902188; GO:0043161; GO:0042787; GO:1901990; GO:0019985; GO:0016032	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Primarily cytoplasmic. Translocates to the nucleus following UV irradiation and subsequently accumulates at sites of DNA damage.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; DNA damage; DNA repair; DNA-binding; Host-virus interaction; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Ubl conjugation; Ubl conjugation pathway	Alternative sequence (1); Beta strand (114); Chain (1); Helix (14); Initiator methionine (1); Modified residue (2); Mutagenesis (6); Natural variant (1); Region (5); Sequence conflict (5); Turn (12)
PPM1F_HUMAN	P49593	PPM1F_HUMAN	reviewed	Protein phosphatase 1F (EC 3.1.3.16) (Ca(2+)/calmodulin-dependent protein kinase phosphatase) (CaM-kinase phosphatase) (CaMKPase) (Partner of PIX 2) (Protein fem-2 homolog) (hFem-2)	PPM1F KIAA0015 POPX2	Homo sapiens (Human)	454	cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]; protein complex [GO:0043234]; calmodulin-dependent protein phosphatase activity [GO:0033192]; metal ion binding [GO:0046872]; phosphatase activity [GO:0016791]; protein serine/threonine phosphatase activity [GO:0004722]; cellular response to drug [GO:0035690]; histone dephosphorylation [GO:0016576]; intrinsic apoptotic signaling pathway [GO:0097193]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; negative regulation of transcription, DNA-templated [GO:0045892]; peptidyl-threonine dephosphorylation [GO:0035970]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of chemotaxis [GO:0050921]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of gene expression [GO:0010628]; positive regulation of growth [GO:0045927]; positive regulation of stress fiber assembly [GO:0051496]	cellular response to drug [GO:0035690]; histone dephosphorylation [GO:0016576]; intrinsic apoptotic signaling pathway [GO:0097193]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; negative regulation of transcription, DNA-templated [GO:0045892]; peptidyl-threonine dephosphorylation [GO:0035970]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of chemotaxis [GO:0050921]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of gene expression [GO:0010628]; positive regulation of growth [GO:0045927]; positive regulation of stress fiber assembly [GO:0051496]	calmodulin-dependent protein phosphatase activity [GO:0033192]; metal ion binding [GO:0046872]; phosphatase activity [GO:0016791]; protein serine/threonine phosphatase activity [GO:0004722]	cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]; protein complex [GO:0043234]	GO:0033192; GO:0035690; GO:0005829; GO:0016576; GO:0097193; GO:0046872; GO:0033137; GO:0006469; GO:0044387; GO:0045892; GO:0035970; GO:0048471; GO:0016791; GO:0010811; GO:0050921; GO:0043280; GO:0010634; GO:0051894; GO:0010628; GO:0045927; GO:0051496; GO:0043234; GO:0004722		Alternative splicing; Apoptosis; Complete proteome; Hydrolase; Magnesium; Manganese; Metal-binding; Polymorphism; Protein phosphatase; Reference proteome	Alternative sequence (2); Chain (1); Compositional bias (1); Domain (1); Erroneous initiation (1); Metal binding (5); Natural variant (4); Sequence conflict (1)
TSN_HUMAN	Q15631	TSN_HUMAN	reviewed	Translin (EC 3.1.-.-) (Component 3 of promoter of RISC) (C3PO)	TSN	Homo sapiens (Human)	228	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; DNA binding [GO:0003677]; endoribonuclease activity [GO:0004521]; mRNA binding [GO:0003729]; sequence-specific DNA binding [GO:0043565]; single-stranded DNA binding [GO:0003697]; DNA recombination [GO:0006310]; gene expression [GO:0010467]; RNA phosphodiester bond hydrolysis, endonucleolytic [GO:0090502]	DNA recombination [GO:0006310]; gene expression [GO:0010467]; RNA phosphodiester bond hydrolysis, endonucleolytic [GO:0090502]	DNA binding [GO:0003677]; endoribonuclease activity [GO:0004521]; mRNA binding [GO:0003729]; sequence-specific DNA binding [GO:0043565]; single-stranded DNA binding [GO:0003697]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0003677; GO:0006310; GO:0090502; GO:0005737; GO:0005829; GO:0004521; GO:0010467; GO:0003729; GO:0005634; GO:0043565; GO:0003697	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11801738}. Nucleus {ECO:0000269|PubMed:11801738}.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; DNA-binding; Endonuclease; Hydrolase; Nuclease; Nucleus; RNA-binding; Reference proteome	Alternative sequence (2); Beta strand (2); Chain (1); Helix (12); Modified residue (2); Region (2); Turn (1)
GUAA_HUMAN	P49915	GUAA_HUMAN	reviewed	GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (GMP synthetase) (Glutamine amidotransferase)	GMPS	Homo sapiens (Human)	693	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; GMP synthase (glutamine-hydrolyzing) activity [GO:0003922]; GMP synthase activity [GO:0003921]; pyrophosphatase activity [GO:0016462]; glutamine metabolic process [GO:0006541]; nucleobase-containing small molecule metabolic process [GO:0055086]; purine nucleobase biosynthetic process [GO:0009113]; purine nucleobase metabolic process [GO:0006144]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168]; response to drug [GO:0042493]; small molecule metabolic process [GO:0044281]	glutamine metabolic process [GO:0006541]; nucleobase-containing small molecule metabolic process [GO:0055086]; purine nucleobase biosynthetic process [GO:0009113]; purine nucleobase metabolic process [GO:0006144]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168]; response to drug [GO:0042493]; small molecule metabolic process [GO:0044281]	ATP binding [GO:0005524]; GMP synthase (glutamine-hydrolyzing) activity [GO:0003922]; GMP synthase activity [GO:0003921]; pyrophosphatase activity [GO:0016462]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0005524; GO:0003922; GO:0003921; GO:0005737; GO:0005829; GO:0006541; GO:0055086; GO:0009113; GO:0006144; GO:0009168; GO:0016462; GO:0042493; GO:0044281	SUBCELLULAR LOCATION: Cytoplasm.	3D-structure; ATP-binding; Acetylation; Alternative splicing; Chromosomal rearrangement; Complete proteome; Cytoplasm; Direct protein sequencing; GMP biosynthesis; Glutamine amidotransferase; Ligase; Nucleotide-binding; Phosphoprotein; Proto-oncogene; Purine biosynthesis; Reference proteome	Active site (3); Alternative sequence (1); Beta strand (24); Binding site (5); Chain (1); Domain (2); Helix (29); Initiator methionine (1); Modified residue (4); Nucleotide binding (1); Sequence conflict (2); Turn (4)
ILF3_HUMAN	Q12906	ILF3_HUMAN	reviewed	Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80)	ILF3 DRBF MPHOSPH4 NF90	Homo sapiens (Human)	894	cytoplasm [GO:0005737]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]; DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; defense response to virus [GO:0051607]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of translation [GO:0017148]; negative regulation of viral genome replication [GO:0045071]; positive regulation of transcription, DNA-templated [GO:0045893]; protein phosphorylation [GO:0006468]; transcription, DNA-templated [GO:0006351]	defense response to virus [GO:0051607]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of translation [GO:0017148]; negative regulation of viral genome replication [GO:0045071]; positive regulation of transcription, DNA-templated [GO:0045893]; protein phosphorylation [GO:0006468]; transcription, DNA-templated [GO:0006351]	DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]	GO:0003677; GO:0003723; GO:0005737; GO:0051607; GO:0003725; GO:0016020; GO:0005739; GO:0045892; GO:0017148; GO:0045071; GO:0005730; GO:0005654; GO:0005634; GO:0044822; GO:0045893; GO:0006468; GO:0030529; GO:0006351	SUBCELLULAR LOCATION: Nucleus, nucleolus. Cytoplasm. Nucleus. Note=Localizes in the cytoplasm in response to viral dsRNA. The unphosphorylated form is retained in the nucleus by ILF2. Phosphorylation at Thr-188 and Thr-315 causes the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.	3D-structure; Acetylation; Alternative splicing; Antiviral defense; Complete proteome; Cytoplasm; DNA-binding; Direct protein sequencing; Methylation; Nucleus; Phosphoprotein; Polymorphism; RNA-binding; Reference proteome; Repeat; Transcription; Transcription regulation	Alternative sequence (9); Beta strand (3); Chain (1); Compositional bias (5); Domain (3); Helix (2); Modified residue (15); Motif (1); Natural variant (2); Region (1); Sequence caution (2); Sequence conflict (15)
HN1_HUMAN	Q9UK76	HN1_HUMAN	reviewed	Hematological and neurological expressed 1 protein (Androgen-regulated protein 2) [Cleaved into: Hematological and neurological expressed 1 protein, N-terminally processed]	HN1 ARM2	Homo sapiens (Human)	154	nucleus [GO:0005634]; developmental process [GO:0032502]	developmental process [GO:0032502]		nucleus [GO:0005634]	GO:0032502; GO:0005634	SUBCELLULAR LOCATION: Nucleus.	Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome	Alternative sequence (2); Chain (2); Initiator methionine (1); Modified residue (8); Sequence conflict (1)
PREP_HUMAN	Q5JRX3	PREP_HUMAN	reviewed	Presequence protease, mitochondrial (hPreP) (EC 3.4.24.-) (Pitrilysin metalloproteinase 1) (Metalloprotease 1) (hMP1)	PITRM1 KIAA1104 MP1	Homo sapiens (Human)	1037	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; enzyme activator activity [GO:0008047]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; positive regulation of catalytic activity [GO:0043085]; proteolysis [GO:0006508]	positive regulation of catalytic activity [GO:0043085]; proteolysis [GO:0006508]	enzyme activator activity [GO:0008047]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0008047; GO:0046872; GO:0004222; GO:0005759; GO:0005739; GO:0043085; GO:0006508	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:16849325}.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Disulfide bond; Hydrolase; Metal-binding; Metalloprotease; Mitochondrion; Polymorphism; Protease; Reference proteome; Transit peptide; Zinc	Active site (1); Alternative sequence (3); Beta strand (33); Chain (1); Disulfide bond (1); Erroneous gene model prediction (1); Erroneous initiation (1); Helix (48); Metal binding (3); Modified residue (6); Mutagenesis (2); Natural variant (13); Sequence conflict (6); Transit peptide (1); Turn (10)
HNRL2_HUMAN	Q1KMD3	HNRL2_HUMAN	reviewed	Heterogeneous nuclear ribonucleoprotein U-like protein 2 (Scaffold-attachment factor A2) (SAF-A2)	HNRNPUL2 HNRPUL2	Homo sapiens (Human)	747	membrane [GO:0016020]; nucleus [GO:0005634]; poly(A) RNA binding [GO:0044822]		poly(A) RNA binding [GO:0044822]	membrane [GO:0016020]; nucleus [GO:0005634]	GO:0016020; GO:0005634; GO:0044822	SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q00PI9}.	Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome	Chain (1); Compositional bias (2); Domain (2); Modified residue (2)
SYF1_HUMAN	Q9HCS7	SYF1_HUMAN	reviewed	Pre-mRNA-splicing factor SYF1 (Protein HCNP) (XPA-binding protein 2)	XAB2 HCNP KIAA1177 SYF1 PP3898	Homo sapiens (Human)	855	catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; blastocyst development [GO:0001824]; DNA repair [GO:0006281]; mRNA splicing, via spliceosome [GO:0000398]; nucleotide-excision repair [GO:0006289]; transcription, DNA-templated [GO:0006351]; transcription-coupled nucleotide-excision repair [GO:0006283]	blastocyst development [GO:0001824]; DNA repair [GO:0006281]; mRNA splicing, via spliceosome [GO:0000398]; nucleotide-excision repair [GO:0006289]; transcription, DNA-templated [GO:0006351]; transcription-coupled nucleotide-excision repair [GO:0006283]		catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0006281; GO:0001824; GO:0071013; GO:0000398; GO:0016020; GO:0005654; GO:0006289; GO:0005634; GO:0006351; GO:0006283	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Detected in the splicing complex carrying pre-mRNA. {ECO:0000250}.	Acetylation; Complete proteome; DNA damage; DNA repair; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Spliceosome; Transcription; mRNA processing; mRNA splicing	Chain (1); Erroneous initiation (1); Frameshift (1); Modified residue (2); Natural variant (3); Repeat (14); Sequence caution (1); Sequence conflict (6)
SERB_HUMAN	P78330	SERB_HUMAN	reviewed	Phosphoserine phosphatase (PSP) (PSPase) (EC 3.1.3.3) (L-3-phosphoserine phosphatase) (O-phosphoserine phosphohydrolase)	PSPH	Homo sapiens (Human)	225	cytoplasm [GO:0005737]; cytosol [GO:0005829]; neuron projection [GO:0043005]; calcium ion binding [GO:0005509]; magnesium ion binding [GO:0000287]; phosphoserine phosphatase activity [GO:0004647]; protein homodimerization activity [GO:0042803]; cellular amino acid biosynthetic process [GO:0008652]; cellular nitrogen compound metabolic process [GO:0034641]; dephosphorylation [GO:0016311]; L-serine biosynthetic process [GO:0006564]; L-serine metabolic process [GO:0006563]; response to mechanical stimulus [GO:0009612]; response to nutrient levels [GO:0031667]; response to testosterone [GO:0033574]; small molecule metabolic process [GO:0044281]	cellular amino acid biosynthetic process [GO:0008652]; cellular nitrogen compound metabolic process [GO:0034641]; dephosphorylation [GO:0016311]; L-serine biosynthetic process [GO:0006564]; L-serine metabolic process [GO:0006563]; response to mechanical stimulus [GO:0009612]; response to nutrient levels [GO:0031667]; response to testosterone [GO:0033574]; small molecule metabolic process [GO:0044281]	calcium ion binding [GO:0005509]; magnesium ion binding [GO:0000287]; phosphoserine phosphatase activity [GO:0004647]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; neuron projection [GO:0043005]	GO:0006564; GO:0006563; GO:0005509; GO:0008652; GO:0034641; GO:0005737; GO:0005829; GO:0016311; GO:0000287; GO:0043005; GO:0004647; GO:0042803; GO:0009612; GO:0031667; GO:0033574; GO:0044281		3D-structure; Acetylation; Amino-acid biosynthesis; Complete proteome; Disease mutation; Hydrolase; Magnesium; Metal-binding; Phosphoprotein; Reference proteome; Serine biosynthesis	Active site (2); Beta strand (10); Binding site (3); Chain (1); Helix (13); Metal binding (3); Modified residue (1); Mutagenesis (10); Natural variant (2); Region (1); Sequence conflict (1); Turn (5)
IQGA1_HUMAN	P46940	IQGA1_HUMAN	reviewed	Ras GTPase-activating-like protein IQGAP1 (p195)	IQGAP1 KIAA0051	Homo sapiens (Human)	1657	actin filament [GO:0005884]; axon [GO:0030424]; cell junction [GO:0030054]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; focal adhesion [GO:0005925]; growth cone [GO:0030426]; lateral plasma membrane [GO:0016328]; microtubule [GO:0005874]; midbody [GO:0030496]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; slit diaphragm [GO:0036057]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; GTPase activator activity [GO:0005096]; GTPase inhibitor activity [GO:0005095]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein serine/threonine kinase activator activity [GO:0043539]; cellular response to calcium ion [GO:0071277]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; energy reserve metabolic process [GO:0006112]; epidermal growth factor receptor signaling pathway [GO:0007173]; fibroblast growth factor receptor signaling pathway [GO:0008543]; glomerular visceral epithelial cell development [GO:0072015]; negative regulation of dephosphorylation [GO:0035305]; negative regulation of GTPase activity [GO:0034260]; neuron projection extension [GO:1990138]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; regulation of cytokine production [GO:0001817]; regulation of insulin secretion [GO:0050796]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]; small molecule metabolic process [GO:0044281]	cellular response to calcium ion [GO:0071277]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; energy reserve metabolic process [GO:0006112]; epidermal growth factor receptor signaling pathway [GO:0007173]; fibroblast growth factor receptor signaling pathway [GO:0008543]; glomerular visceral epithelial cell development [GO:0072015]; negative regulation of dephosphorylation [GO:0035305]; negative regulation of GTPase activity [GO:0034260]; neuron projection extension [GO:1990138]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; regulation of cytokine production [GO:0001817]; regulation of insulin secretion [GO:0050796]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]; small molecule metabolic process [GO:0044281]	calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; GTPase activator activity [GO:0005096]; GTPase inhibitor activity [GO:0005095]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein serine/threonine kinase activator activity [GO:0043539]	actin filament [GO:0005884]; axon [GO:0030424]; cell junction [GO:0030054]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; focal adhesion [GO:0005925]; growth cone [GO:0030426]; lateral plasma membrane [GO:0016328]; microtubule [GO:0005874]; midbody [GO:0030496]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; slit diaphragm [GO:0036057]	GO:0005096; GO:0005095; GO:0005884; GO:0030424; GO:0005509; GO:0005516; GO:0030054; GO:0031252; GO:0071277; GO:0071364; GO:0036120; GO:0005737; GO:0036464; GO:0005829; GO:0006112; GO:0007173; GO:0070062; GO:0031234; GO:0008543; GO:0005925; GO:0072015; GO:0030426; GO:0016328; GO:0005874; GO:0030496; GO:0034260; GO:0035305; GO:0043005; GO:1990138; GO:0005654; GO:0005547; GO:0005886; GO:0048008; GO:0043547; GO:0045860; GO:0071902; GO:0019901; GO:0019903; GO:0043539; GO:0001817; GO:0050796; GO:0007165; GO:0036057; GO:0007264; GO:0044281	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15355962}.	3D-structure; Acetylation; Calmodulin-binding; Cell membrane; Complete proteome; Direct protein sequencing; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat	Beta strand (11); Chain (1); Domain (7); Erroneous initiation (1); Helix (39); Initiator methionine (1); Modified residue (6); Mutagenesis (4); Natural variant (1); Region (2); Turn (8)
2A5D_HUMAN	Q14738	2A5D_HUMAN	reviewed	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A B subunit isoform B'-delta) (PP2A B subunit isoform B56-delta) (PP2A B subunit isoform PR61-delta) (PP2A B subunit isoform R5-delta)	PPP2R5D	Homo sapiens (Human)	602	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159]; protein phosphatase type 2A regulator activity [GO:0008601]; protein serine/threonine phosphatase activity [GO:0004722]; canonical glycolysis [GO:0061621]; carbohydrate metabolic process [GO:0005975]; dephosphorylation [GO:0016311]; energy reserve metabolic process [GO:0006112]; glucose metabolic process [GO:0006006]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; MyD88-independent toll-like receptor signaling pathway [GO:0002756]; nervous system development [GO:0007399]; neurotrophin TRK receptor signaling pathway [GO:0048011]; regulation of protein phosphatase type 2A activity [GO:0034047]; small molecule metabolic process [GO:0044281]; stress-activated MAPK cascade [GO:0051403]; toll-like receptor 10 signaling pathway [GO:0034166]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 5 signaling pathway [GO:0034146]; toll-like receptor 9 signaling pathway [GO:0034162]; toll-like receptor signaling pathway [GO:0002224]; toll-like receptor TLR1:TLR2 signaling pathway [GO:0038123]; toll-like receptor TLR6:TLR2 signaling pathway [GO:0038124]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]	canonical glycolysis [GO:0061621]; carbohydrate metabolic process [GO:0005975]; dephosphorylation [GO:0016311]; energy reserve metabolic process [GO:0006112]; glucose metabolic process [GO:0006006]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; MyD88-independent toll-like receptor signaling pathway [GO:0002756]; nervous system development [GO:0007399]; neurotrophin TRK receptor signaling pathway [GO:0048011]; regulation of protein phosphatase type 2A activity [GO:0034047]; small molecule metabolic process [GO:0044281]; stress-activated MAPK cascade [GO:0051403]; toll-like receptor 10 signaling pathway [GO:0034166]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 5 signaling pathway [GO:0034146]; toll-like receptor 9 signaling pathway [GO:0034162]; toll-like receptor signaling pathway [GO:0002224]; toll-like receptor TLR1:TLR2 signaling pathway [GO:0038123]; toll-like receptor TLR6:TLR2 signaling pathway [GO:0038124]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]	protein phosphatase type 2A regulator activity [GO:0008601]; protein serine/threonine phosphatase activity [GO:0004722]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159]	GO:0002755; GO:0002756; GO:0035666; GO:0061621; GO:0005975; GO:0005829; GO:0016311; GO:0006112; GO:0006006; GO:0045087; GO:0007399; GO:0048011; GO:0005654; GO:0005634; GO:0000159; GO:0008601; GO:0004722; GO:0034047; GO:0044281; GO:0051403; GO:0034166; GO:0034134; GO:0034138; GO:0034142; GO:0034146; GO:0034162; GO:0038123; GO:0038124; GO:0002224	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Nuclear in interphase, nuclear during mitosis.	Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat	Alternative sequence (2); Chain (1); Modified residue (2); Motif (2); Natural variant (1); Region (1); Repeat (8)
G3V0E5_HUMAN	G3V0E5	G3V0E5_HUMAN	unreviewed	Transferrin receptor (P90, CD71), isoform CRA_c (Transferrin receptor protein 1)	TFRC hCG_22086	Homo sapiens (Human)	679	intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; transferrin receptor activity [GO:0004998]; cellular iron ion homeostasis [GO:0006879]; transferrin transport [GO:0033572]	cellular iron ion homeostasis [GO:0006879]; transferrin transport [GO:0033572]	transferrin receptor activity [GO:0004998]	intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]	GO:0006879; GO:0043231; GO:0005886; GO:0004998; GO:0033572		Complete proteome; Proteomics identification; Receptor; Reference proteome	
TFR1_HUMAN	P02786	TFR1_HUMAN	reviewed	Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (T9) (p90) (CD antigen CD71) [Cleaved into: Transferrin receptor protein 1, serum form (sTfR)]	TFRC	Homo sapiens (Human)	760	blood microparticle [GO:0072562]; cell surface [GO:0009986]; coated pit [GO:0005905]; cytoplasmic membrane-bounded vesicle [GO:0016023]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; HFE-transferrin receptor complex [GO:1990712]; integral component of plasma membrane [GO:0005887]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; double-stranded RNA binding [GO:0003725]; glycoprotein binding [GO:0001948]; identical protein binding [GO:0042802]; poly(A) RNA binding [GO:0044822]; transferrin receptor activity [GO:0004998]; cellular iron ion homeostasis [GO:0006879]; cellular response to drug [GO:0035690]; iron ion import [GO:0097286]; osteoclast differentiation [GO:0030316]; positive regulation of bone resorption [GO:0045780]; transferrin transport [GO:0033572]; transmembrane transport [GO:0055085]; viral process [GO:0016032]	cellular iron ion homeostasis [GO:0006879]; cellular response to drug [GO:0035690]; iron ion import [GO:0097286]; osteoclast differentiation [GO:0030316]; positive regulation of bone resorption [GO:0045780]; transferrin transport [GO:0033572]; transmembrane transport [GO:0055085]; viral process [GO:0016032]	double-stranded RNA binding [GO:0003725]; glycoprotein binding [GO:0001948]; identical protein binding [GO:0042802]; poly(A) RNA binding [GO:0044822]; transferrin receptor activity [GO:0004998]	blood microparticle [GO:0072562]; cell surface [GO:0009986]; coated pit [GO:0005905]; cytoplasmic membrane-bounded vesicle [GO:0016023]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; HFE-transferrin receptor complex [GO:1990712]; integral component of plasma membrane [GO:0005887]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]	GO:1990712; GO:0072562; GO:0009986; GO:0006879; GO:0035690; GO:0005905; GO:0016023; GO:0003725; GO:0005768; GO:0009897; GO:0070062; GO:0005576; GO:0005615; GO:1903561; GO:0001948; GO:0042802; GO:0005887; GO:0043231; GO:0097286; GO:0042470; GO:0016020; GO:0030316; GO:0048471; GO:0005886; GO:0044822; GO:0045780; GO:0055037; GO:0004998; GO:0033572; GO:0055085; GO:0016032	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17081065}; Single-pass type II membrane protein {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.; SUBCELLULAR LOCATION: Transferrin receptor protein 1, serum form: Secreted.	3D-structure; Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; Endocytosis; Glycoprotein; Host-virus interaction; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Secreted; Signal-anchor; Transmembrane; Transmembrane helix	Beta strand (27); Chain (2); Disulfide bond (2); Domain (1); Erroneous initiation (1); Glycosylation (4); Helix (26); Lipidation (2); Modified residue (3); Motif (3); Mutagenesis (25); Natural variant (4); Region (2); Sequence conflict (3); Site (1); Topological domain (2); Transmembrane (1); Turn (13)
ERO1A_HUMAN	Q96HE7	ERO1A_HUMAN	reviewed	ERO1-like protein alpha (ERO1-L) (ERO1-L-alpha) (EC 1.8.4.-) (Endoplasmic oxidoreductin-1-like protein) (Oxidoreductin-1-L-alpha)	ERO1L UNQ434/PRO865	Homo sapiens (Human)	468	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [GO:0016671]; protein disulfide isomerase activity [GO:0003756]; protein disulfide oxidoreductase activity [GO:0015035]; 4-hydroxyproline metabolic process [GO:0019471]; brown fat cell differentiation [GO:0050873]; cell redox homeostasis [GO:0045454]; cellular protein metabolic process [GO:0044267]; cellular protein modification process [GO:0006464]; chaperone mediated protein folding requiring cofactor [GO:0051085]; endoplasmic reticulum unfolded protein response [GO:0030968]; extracellular matrix organization [GO:0030198]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; protein folding [GO:0006457]; protein maturation by protein folding [GO:0022417]; release of sequestered calcium ion into cytosol [GO:0051209]; response to endoplasmic reticulum stress [GO:0034976]; response to reactive oxygen species [GO:0000302]; response to temperature stimulus [GO:0009266]	4-hydroxyproline metabolic process [GO:0019471]; brown fat cell differentiation [GO:0050873]; cell redox homeostasis [GO:0045454]; cellular protein metabolic process [GO:0044267]; cellular protein modification process [GO:0006464]; chaperone mediated protein folding requiring cofactor [GO:0051085]; endoplasmic reticulum unfolded protein response [GO:0030968]; extracellular matrix organization [GO:0030198]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; protein folding [GO:0006457]; protein maturation by protein folding [GO:0022417]; release of sequestered calcium ion into cytosol [GO:0051209]; response to endoplasmic reticulum stress [GO:0034976]; response to reactive oxygen species [GO:0000302]; response to temperature stimulus [GO:0009266]	oxidoreductase activity [GO:0016491]; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [GO:0016671]; protein disulfide isomerase activity [GO:0003756]; protein disulfide oxidoreductase activity [GO:0015035]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]	GO:0019471; GO:0050873; GO:0045454; GO:0044267; GO:0006464; GO:0051085; GO:0005783; GO:0005788; GO:0005789; GO:0030968; GO:0030198; GO:0043231; GO:0070059; GO:0016020; GO:0016491; GO:0016671; GO:0003756; GO:0015035; GO:0006457; GO:0022417; GO:0051209; GO:0034976; GO:0000302; GO:0009266	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10671517, ECO:0000269|PubMed:14517240}; Peripheral membrane protein {ECO:0000269|PubMed:10671517, ECO:0000269|PubMed:14517240}; Lumenal side {ECO:0000269|PubMed:10671517, ECO:0000269|PubMed:14517240}. Note=The association with ERP44 is essential for its retention in the endoplasmic reticulum.	3D-structure; Apoptosis; Complete proteome; Direct protein sequencing; Disulfide bond; Electron transport; Endoplasmic reticulum; FAD; Flavoprotein; Glycoprotein; Membrane; Oxidoreductase; Phosphoprotein; Redox-active center; Reference proteome; Signal; Transport	Beta strand (10); Binding site (7); Chain (1); Disulfide bond (8); Glycosylation (2); Helix (17); Modified residue (2); Mutagenesis (16); Sequence conflict (1); Signal peptide (1)
TYY1_HUMAN	P25490	TYY1_HUMAN	reviewed	Transcriptional repressor protein YY1 (Delta transcription factor) (INO80 complex subunit S) (NF-E1) (Yin and yang 1) (YY-1)	YY1 INO80S	Homo sapiens (Human)	414	Ino80 complex [GO:0031011]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; transcription factor complex [GO:0005667]; DNA binding [GO:0003677]; enhancer sequence-specific DNA binding [GO:0001158]; four-way junction DNA binding [GO:0000400]; RNA binding [GO:0003723]; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [GO:0001078]; sequence-specific DNA binding transcription factor activity [GO:0003700]; SMAD binding [GO:0046332]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; transcription regulatory region DNA binding [GO:0044212]; zinc ion binding [GO:0008270]; anterior/posterior pattern specification [GO:0009952]; camera-type eye morphogenesis [GO:0048593]; cell differentiation [GO:0030154]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to UV [GO:0034644]; chromosome organization [GO:0051276]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of gene expression [GO:0010628]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; response to prostaglandin F [GO:0034696]; response to UV-C [GO:0010225]; RNA localization [GO:0006403]; spermatogenesis [GO:0007283]	anterior/posterior pattern specification [GO:0009952]; camera-type eye morphogenesis [GO:0048593]; cell differentiation [GO:0030154]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to UV [GO:0034644]; chromosome organization [GO:0051276]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of gene expression [GO:0010628]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; response to prostaglandin F [GO:0034696]; response to UV-C [GO:0010225]; RNA localization [GO:0006403]; spermatogenesis [GO:0007283]	DNA binding [GO:0003677]; enhancer sequence-specific DNA binding [GO:0001158]; four-way junction DNA binding [GO:0000400]; RNA binding [GO:0003723]; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [GO:0001078]; sequence-specific DNA binding transcription factor activity [GO:0003700]; SMAD binding [GO:0046332]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; transcription regulatory region DNA binding [GO:0044212]; zinc ion binding [GO:0008270]	Ino80 complex [GO:0031011]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; transcription factor complex [GO:0005667]	GO:0003677; GO:0031011; GO:0031519; GO:0003723; GO:0006403; GO:0001078; GO:0046332; GO:0009952; GO:0048593; GO:0030154; GO:0006974; GO:0034644; GO:0051276; GO:0000724; GO:0001158; GO:0000400; GO:0010629; GO:0000122; GO:0016363; GO:0005634; GO:0010628; GO:0006357; GO:0010225; GO:0034696; GO:0003700; GO:0007283; GO:0003713; GO:0003714; GO:0005667; GO:0044212; GO:0008270	SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000269|PubMed:18026119, ECO:0000269|PubMed:23385818, ECO:0000269|PubMed:9493912}. Note=Associated with the nuclear matrix.	3D-structure; ADP-ribosylation; Activator; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA-binding; Differentiation; Direct protein sequencing; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Repressor; Spermatogenesis; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger	Beta strand (5); Chain (1); Compositional bias (4); Helix (6); Metal binding (16); Modified residue (3); Natural variant (1); Region (5); Sequence conflict (2); Turn (3); Zinc finger (4)
RPR1B_HUMAN	Q9NQG5	RPR1B_HUMAN	reviewed	Regulation of nuclear pre-mRNA domain-containing protein 1B (Cell cycle-related and expression-elevated protein in tumor)	RPRD1B C20orf77 CREPT	Homo sapiens (Human)	326	DNA-directed RNA polymerase II, holoenzyme [GO:0016591]; nucleus [GO:0005634]; RNA polymerase II core binding [GO:0000993]; dephosphorylation of RNA polymerase II C-terminal domain [GO:0070940]; positive regulation of cell proliferation [GO:0008284]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell cycle process [GO:0010564]; transcription, DNA-templated [GO:0006351]	dephosphorylation of RNA polymerase II C-terminal domain [GO:0070940]; positive regulation of cell proliferation [GO:0008284]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of cell cycle process [GO:0010564]; transcription, DNA-templated [GO:0006351]	RNA polymerase II core binding [GO:0000993]	DNA-directed RNA polymerase II, holoenzyme [GO:0016591]; nucleus [GO:0005634]	GO:0016591; GO:0000993; GO:0070940; GO:0005634; GO:0008284; GO:0045944; GO:0010564; GO:0006351	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22264791}.	3D-structure; Acetylation; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation	Chain (1); Domain (1); Helix (13); Initiator methionine (1); Modified residue (5); Sequence caution (1); Sequence conflict (1); Turn (1)
RS28_HUMAN	P62857	RS28_HUMAN	reviewed	40S ribosomal protein S28	RPS28	Homo sapiens (Human)	69	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; small ribosomal subunit [GO:0015935]; poly(A) RNA binding [GO:0044822]; structural constituent of ribosome [GO:0003735]; cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; ribosomal small subunit biogenesis [GO:0042274]; rRNA export from nucleus [GO:0006407]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; ribosomal small subunit biogenesis [GO:0042274]; rRNA export from nucleus [GO:0006407]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	poly(A) RNA binding [GO:0044822]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; small ribosomal subunit [GO:0015935]	GO:0006614; GO:0044267; GO:0005737; GO:0005829; GO:0022627; GO:0070062; GO:0010467; GO:0000184; GO:0044822; GO:0006407; GO:0006364; GO:0042274; GO:0015935; GO:0003735; GO:0006412; GO:0006414; GO:0006413; GO:0006415; GO:0019058; GO:0016032; GO:0019083		3D-structure; Complete proteome; Diamond-Blackfan anemia; Direct protein sequencing; Reference proteome; Ribonucleoprotein; Ribosomal protein	Chain (1); Sequence conflict (1)
U520_HUMAN	O75643	U520_HUMAN	reviewed	U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD)	SNRNP200 ASCC3L1 HELIC2 KIAA0788	Homo sapiens (Human)	2136	catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U5 snRNP [GO:0005682]; ATP binding [GO:0005524]; ATP-dependent helicase activity [GO:0008026]; ATP-dependent RNA helicase activity [GO:0004004]; identical protein binding [GO:0042802]; poly(A) RNA binding [GO:0044822]; cis assembly of pre-catalytic spliceosome [GO:0000354]; gene expression [GO:0010467]; mRNA splicing, via spliceosome [GO:0000398]; osteoblast differentiation [GO:0001649]; RNA splicing [GO:0008380]	cis assembly of pre-catalytic spliceosome [GO:0000354]; gene expression [GO:0010467]; mRNA splicing, via spliceosome [GO:0000398]; osteoblast differentiation [GO:0001649]; RNA splicing [GO:0008380]	ATP binding [GO:0005524]; ATP-dependent helicase activity [GO:0008026]; ATP-dependent RNA helicase activity [GO:0004004]; identical protein binding [GO:0042802]; poly(A) RNA binding [GO:0044822]	catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U5 snRNP [GO:0005682]	GO:0005524; GO:0004004; GO:0008026; GO:0008380; GO:0005682; GO:0071013; GO:0000354; GO:0010467; GO:0042802; GO:0000398; GO:0016020; GO:0005654; GO:0005634; GO:0001649; GO:0044822; GO:0005681	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9539711}.	3D-structure; ATP-binding; Acetylation; Alternative splicing; Coiled coil; Complete proteome; Direct protein sequencing; Disease mutation; Helicase; Hydrolase; Isopeptide bond; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Retinitis pigmentosa; Spliceosome; Ubl conjugation; mRNA processing; mRNA splicing	Alternative sequence (1); Beta strand (61); Chain (1); Coiled coil (1); Cross-link (5); Domain (6); Erroneous initiation (1); Helix (87); Modified residue (9); Motif (2); Mutagenesis (5); Natural variant (14); Nucleotide binding (2); Sequence conflict (16); Turn (21)
FKBP4_HUMAN	Q02790	FKBP4_HUMAN	reviewed	Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed]	FKBP4 FKBP52	Homo sapiens (Human)	459	axonal growth cone [GO:0044295]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; ATP binding [GO:0005524]; FK506 binding [GO:0005528]; GTP binding [GO:0005525]; heat shock protein binding [GO:0031072]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; poly(A) RNA binding [GO:0044822]; protein binding, bridging [GO:0030674]; androgen receptor signaling pathway [GO:0030521]; cellular response to heat [GO:0034605]; chaperone-mediated protein folding [GO:0061077]; copper ion transport [GO:0006825]; embryo implantation [GO:0007566]; male sex differentiation [GO:0046661]; negative regulation of microtubule polymerization [GO:0031115]; negative regulation of microtubule polymerization or depolymerization [GO:0031111]; negative regulation of neuron projection development [GO:0010977]; prostate gland development [GO:0030850]; protein complex localization [GO:0031503]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]; regulation of cellular response to heat [GO:1900034]; steroid hormone receptor complex assembly [GO:0006463]	androgen receptor signaling pathway [GO:0030521]; cellular response to heat [GO:0034605]; chaperone-mediated protein folding [GO:0061077]; copper ion transport [GO:0006825]; embryo implantation [GO:0007566]; male sex differentiation [GO:0046661]; negative regulation of microtubule polymerization [GO:0031115]; negative regulation of microtubule polymerization or depolymerization [GO:0031111]; negative regulation of neuron projection development [GO:0010977]; prostate gland development [GO:0030850]; protein complex localization [GO:0031503]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]; regulation of cellular response to heat [GO:1900034]; steroid hormone receptor complex assembly [GO:0006463]	ATP binding [GO:0005524]; FK506 binding [GO:0005528]; GTP binding [GO:0005525]; heat shock protein binding [GO:0031072]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; poly(A) RNA binding [GO:0044822]; protein binding, bridging [GO:0030674]	axonal growth cone [GO:0044295]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]	GO:0005524; GO:0005528; GO:0005525; GO:0030521; GO:0044295; GO:0034605; GO:0061077; GO:0006825; GO:0005737; GO:0005829; GO:0007566; GO:0005789; GO:0070062; GO:0031072; GO:0046661; GO:0005874; GO:0005739; GO:0031115; GO:0031111; GO:0010977; GO:0043025; GO:0005654; GO:0003755; GO:0048471; GO:0044822; GO:0030850; GO:0030674; GO:0031503; GO:0006457; GO:0000413; GO:1900034; GO:0006463	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Mitochondrion. Nucleus. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor.	3D-structure; Acetylation; Chaperone; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Isomerase; Microtubule; Mitochondrion; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Rotamase; TPR repeat	Beta strand (16); Chain (2); Domain (2); Helix (15); Initiator methionine (1); Modified residue (6); Mutagenesis (1); Natural variant (1); Region (1); Repeat (3); Turn (5)
TCTP_HUMAN	P13693	TCTP_HUMAN	reviewed	Translationally-controlled tumor protein (TCTP) (Fortilin) (Histamine-releasing factor) (HRF) (p23)	TPT1	Homo sapiens (Human)	172	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; multivesicular body [GO:0005771]; nucleus [GO:0005634]; calcium ion binding [GO:0005509]; poly(A) RNA binding [GO:0044822]; calcium ion transport [GO:0006816]; cellular calcium ion homeostasis [GO:0006874]; negative regulation of apoptotic process [GO:0043066]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; regulation of apoptotic process [GO:0042981]; response to virus [GO:0009615]	calcium ion transport [GO:0006816]; cellular calcium ion homeostasis [GO:0006874]; negative regulation of apoptotic process [GO:0043066]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; regulation of apoptotic process [GO:0042981]; response to virus [GO:0009615]	calcium ion binding [GO:0005509]; poly(A) RNA binding [GO:0044822]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; multivesicular body [GO:0005771]; nucleus [GO:0005634]	GO:0005509; GO:0006816; GO:0006874; GO:0005737; GO:0070062; GO:0005615; GO:0005771; GO:0043066; GO:1902230; GO:0005634; GO:0044822; GO:0042981; GO:0009615	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9059837}.	3D-structure; Alternative splicing; Calcium; Complete proteome; Cytoplasm; Direct protein sequencing; Phosphoprotein; Polymorphism; Reference proteome	Alternative sequence (1); Beta strand (9); Chain (1); Helix (7); Modified residue (3); Natural variant (1); Sequence conflict (2); Turn (1)
Q5W0H4_HUMAN	Q5W0H4	Q5W0H4_HUMAN	unreviewed	Translationally-controlled tumor protein	TPT1	Homo sapiens (Human)	188	cytoplasm [GO:0005737]			cytoplasm [GO:0005737]	GO:0005737		3D-structure; Complete proteome; Proteomics identification; Reference proteome	
H31_HUMAN	P68431	H31_HUMAN	reviewed	Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)	HIST1H3A H3FA; HIST1H3B H3FL; HIST1H3C H3FC; HIST1H3D H3FB; HIST1H3E H3FD; HIST1H3F H3FI; HIST1H3G H3FH; HIST1H3H H3FK; HIST1H3I H3FF; HIST1H3J H3FJ	Homo sapiens (Human)	136	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; nuclear chromosome [GO:0000228]; nuclear nucleosome [GO:0000788]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; protein complex [GO:0043234]; DNA binding [GO:0003677]; histone binding [GO:0042393]; blood coagulation [GO:0007596]; chromatin organization [GO:0006325]; chromatin silencing at rDNA [GO:0000183]; DNA methylation on cytosine [GO:0032776]; DNA replication-dependent nucleosome assembly [GO:0006335]; gene expression [GO:0010467]; negative regulation of gene expression, epigenetic [GO:0045814]; nucleosome assembly [GO:0006334]; positive regulation of defense response to virus by host [GO:0002230]; protein heterotetramerization [GO:0051290]; regulation of gene expression, epigenetic [GO:0040029]; regulation of gene silencing [GO:0060968]; small GTPase mediated signal transduction [GO:0007264]	blood coagulation [GO:0007596]; chromatin organization [GO:0006325]; chromatin silencing at rDNA [GO:0000183]; DNA methylation on cytosine [GO:0032776]; DNA replication-dependent nucleosome assembly [GO:0006335]; gene expression [GO:0010467]; negative regulation of gene expression, epigenetic [GO:0045814]; nucleosome assembly [GO:0006334]; positive regulation of defense response to virus by host [GO:0002230]; protein heterotetramerization [GO:0051290]; regulation of gene expression, epigenetic [GO:0040029]; regulation of gene silencing [GO:0060968]; small GTPase mediated signal transduction [GO:0007264]	DNA binding [GO:0003677]; histone binding [GO:0042393]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; nuclear chromosome [GO:0000228]; nuclear nucleosome [GO:0000788]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; protein complex [GO:0043234]	GO:0003677; GO:0032776; GO:0006335; GO:0007596; GO:0006325; GO:0000183; GO:0070062; GO:0005576; GO:0010467; GO:0042393; GO:0016020; GO:0045814; GO:0000228; GO:0000788; GO:0005654; GO:0000786; GO:0006334; GO:0005634; GO:0002230; GO:0043234; GO:0051290; GO:0040029; GO:0060968; GO:0007264	SUBCELLULAR LOCATION: Nucleus. Chromosome.	3D-structure; Acetylation; Chromosome; Citrullination; Complete proteome; DNA-binding; Direct protein sequencing; Methylation; Nucleosome core; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation	Beta strand (2); Chain (1); Helix (5); Initiator methionine (1); Modified residue (57); Sequence conflict (4); Turn (1)
H32_HUMAN	Q71DI3	H32_HUMAN	reviewed	Histone H3.2 (Histone H3/m) (Histone H3/o)	HIST2H3A; HIST2H3C H3F2 H3FM; HIST2H3D	Homo sapiens (Human)	136	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; histone binding [GO:0042393]; blood coagulation [GO:0007596]; chromatin silencing at rDNA [GO:0000183]; DNA methylation on cytosine [GO:0032776]; gene expression [GO:0010467]; negative regulation of gene expression, epigenetic [GO:0045814]; nucleosome assembly [GO:0006334]; regulation of gene expression, epigenetic [GO:0040029]; small GTPase mediated signal transduction [GO:0007264]	blood coagulation [GO:0007596]; chromatin silencing at rDNA [GO:0000183]; DNA methylation on cytosine [GO:0032776]; gene expression [GO:0010467]; negative regulation of gene expression, epigenetic [GO:0045814]; nucleosome assembly [GO:0006334]; regulation of gene expression, epigenetic [GO:0040029]; small GTPase mediated signal transduction [GO:0007264]	DNA binding [GO:0003677]; histone binding [GO:0042393]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nucleoplasm [GO:0005654]; nucleosome [GO:0000786]; nucleus [GO:0005634]	GO:0003677; GO:0032776; GO:0007596; GO:0000183; GO:0070062; GO:0005576; GO:0010467; GO:0042393; GO:0045814; GO:0005654; GO:0000786; GO:0006334; GO:0005634; GO:0040029; GO:0007264	SUBCELLULAR LOCATION: Nucleus. Chromosome.	3D-structure; Acetylation; Chromosome; Citrullination; Complete proteome; DNA-binding; Direct protein sequencing; Methylation; Nucleosome core; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation	Beta strand (2); Chain (1); Helix (5); Initiator methionine (1); Modified residue (57); Natural variant (2); Turn (1)
E2AK4_HUMAN	Q9P2K8	E2AK4_HUMAN	reviewed	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein)	EIF2AK4 GCN2 KIAA1338	Homo sapiens (Human)	1649	cytosolic ribosome [GO:0022626]; ATP binding [GO:0005524]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; protein serine/threonine kinase activity [GO:0004674]; cellular response to starvation [GO:0009267]; endoplasmic reticulum unfolded protein response [GO:0030968]; negative regulation of translation [GO:0017148]; protein phosphorylation [GO:0006468]; regulation of translational initiation [GO:0006446]; regulation of translational initiation by eIF2 alpha phosphorylation [GO:0010998]	cellular response to starvation [GO:0009267]; endoplasmic reticulum unfolded protein response [GO:0030968]; negative regulation of translation [GO:0017148]; protein phosphorylation [GO:0006468]; regulation of translational initiation [GO:0006446]; regulation of translational initiation by eIF2 alpha phosphorylation [GO:0010998]	ATP binding [GO:0005524]; eukaryotic translation initiation factor 2alpha kinase activity [GO:0004694]; protein serine/threonine kinase activity [GO:0004674]	cytosolic ribosome [GO:0022626]	GO:0005524; GO:0009267; GO:0022626; GO:0030968; GO:0004694; GO:0017148; GO:0006468; GO:0004674; GO:0006446; GO:0010998		ATP-binding; Acetylation; Alternative splicing; Complete proteome; Disease mutation; Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase	Active site (1); Alternative sequence (3); Binding site (1); Chain (1); Compositional bias (1); Domain (3); Erroneous initiation (1); Modified residue (5); Natural variant (11); Nucleotide binding (1); Region (1); Sequence caution (1); Sequence conflict (5)
MAST2_HUMAN	Q6P0Q8	MAST2_HUMAN	reviewed	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1)	MAST2 KIAA0807 MAST205	Homo sapiens (Human)	1798	cytoplasm [GO:0005737]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; phosphatase binding [GO:0019902]; protein serine/threonine kinase activity [GO:0004674]; protein phosphorylation [GO:0006468]; regulation of interleukin-12 biosynthetic process [GO:0045075]; spermatid differentiation [GO:0048515]	protein phosphorylation [GO:0006468]; regulation of interleukin-12 biosynthetic process [GO:0045075]; spermatid differentiation [GO:0048515]	ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; phosphatase binding [GO:0019902]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; microtubule cytoskeleton [GO:0015630]; plasma membrane [GO:0005886]	GO:0005524; GO:0005737; GO:0000287; GO:0015630; GO:0019902; GO:0005886; GO:0006468; GO:0004674; GO:0045075; GO:0048515	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12117771}. Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Recruited to the sub-membranous area on interaction with CDHR2.	3D-structure; ATP-binding; Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Kinase; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase; Ubl conjugation	Active site (1); Alternative sequence (3); Beta strand (7); Binding site (1); Chain (1); Domain (3); Erroneous gene model prediction (3); Erroneous initiation (1); Frameshift (2); Helix (2); Modified residue (8); Natural variant (16); Nucleotide binding (1); Sequence conflict (1)
KPRB_HUMAN	O60256	KPRB_HUMAN	reviewed	Phosphoribosyl pyrophosphate synthase-associated protein 2 (PRPP synthase-associated protein 2) (41 kDa phosphoribosypyrophosphate synthetase-associated protein) (PAP41)	PRPSAP2	Homo sapiens (Human)	369	ribose phosphate diphosphokinase complex [GO:0002189]; enzyme inhibitor activity [GO:0004857]; magnesium ion binding [GO:0000287]; ribose phosphate diphosphokinase activity [GO:0004749]; bone development [GO:0060348]; negative regulation of catalytic activity [GO:0043086]; nucleobase-containing compound metabolic process [GO:0006139]; nucleotide biosynthetic process [GO:0009165]	bone development [GO:0060348]; negative regulation of catalytic activity [GO:0043086]; nucleobase-containing compound metabolic process [GO:0006139]; nucleotide biosynthetic process [GO:0009165]	enzyme inhibitor activity [GO:0004857]; magnesium ion binding [GO:0000287]; ribose phosphate diphosphokinase activity [GO:0004749]	ribose phosphate diphosphokinase complex [GO:0002189]	GO:0060348; GO:0004857; GO:0000287; GO:0043086; GO:0006139; GO:0009165; GO:0004749; GO:0002189		3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Nucleotide biosynthesis; Phosphoprotein; Reference proteome	Alternative sequence (3); Beta strand (16); Chain (1); Helix (13); Modified residue (4); Sequence conflict (1)
SUCB2_HUMAN	Q96I99	SUCB2_HUMAN	reviewed	Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial (EC 6.2.1.4) (GTP-specific succinyl-CoA synthetase subunit beta) (Succinyl-CoA synthetase beta-G chain) (SCS-betaG)	SUCLG2	Homo sapiens (Human)	432	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; succinate-CoA ligase complex (GDP-forming) [GO:0045244]; ATP binding [GO:0005524]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; succinate-CoA ligase (GDP-forming) activity [GO:0004776]; cellular metabolic process [GO:0044237]; small molecule metabolic process [GO:0044281]; succinate metabolic process [GO:0006105]; succinyl-CoA metabolic process [GO:0006104]; tricarboxylic acid cycle [GO:0006099]	cellular metabolic process [GO:0044237]; small molecule metabolic process [GO:0044281]; succinate metabolic process [GO:0006105]; succinyl-CoA metabolic process [GO:0006104]; tricarboxylic acid cycle [GO:0006099]	ATP binding [GO:0005524]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; succinate-CoA ligase (GDP-forming) activity [GO:0004776]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; succinate-CoA ligase complex (GDP-forming) [GO:0045244]	GO:0005524; GO:0019003; GO:0005525; GO:0044237; GO:0005759; GO:0005739; GO:0005886; GO:0044281; GO:0006105; GO:0004776; GO:0045244; GO:0006104; GO:0006099	SUBCELLULAR LOCATION: Mitochondrion.	Acetylation; Alternative splicing; Complete proteome; GTP-binding; Ligase; Mitochondrion; Nucleotide-binding; Polymorphism; Reference proteome; Transit peptide; Tricarboxylic acid cycle	Alternative sequence (1); Chain (1); Domain (1); Erroneous initiation (2); Erroneous termination (1); Modified residue (13); Natural variant (2); Sequence conflict (2); Transit peptide (1)
ARP2_HUMAN	P61160	ARP2_HUMAN	reviewed	Actin-related protein 2 (Actin-like protein 2)	ACTR2 ARP2	Homo sapiens (Human)	394	actin cap [GO:0030478]; actin cytoskeleton [GO:0015629]; Arp2/3 protein complex [GO:0005885]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; ATP binding [GO:0005524]; structural constituent of cytoskeleton [GO:0005200]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; asymmetric cell division [GO:0008356]; axon guidance [GO:0007411]; cilium assembly [GO:0042384]; cytoplasmic transport [GO:0016482]; ephrin receptor signaling pathway [GO:0048013]; establishment or maintenance of cell polarity [GO:0007163]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; innate immune response [GO:0045087]; meiotic chromosome movement towards spindle pole [GO:0016344]; meiotic cytokinesis [GO:0033206]; movement of cell or subcellular component [GO:0006928]; small GTPase mediated signal transduction [GO:0007264]; spindle localization [GO:0051653]	Arp2/3 complex-mediated actin nucleation [GO:0034314]; asymmetric cell division [GO:0008356]; axon guidance [GO:0007411]; cilium assembly [GO:0042384]; cytoplasmic transport [GO:0016482]; ephrin receptor signaling pathway [GO:0048013]; establishment or maintenance of cell polarity [GO:0007163]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; innate immune response [GO:0045087]; meiotic chromosome movement towards spindle pole [GO:0016344]; meiotic cytokinesis [GO:0033206]; movement of cell or subcellular component [GO:0006928]; small GTPase mediated signal transduction [GO:0007264]; spindle localization [GO:0051653]	ATP binding [GO:0005524]; structural constituent of cytoskeleton [GO:0005200]	actin cap [GO:0030478]; actin cytoskeleton [GO:0015629]; Arp2/3 protein complex [GO:0005885]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]	GO:0005524; GO:0034314; GO:0005885; GO:0038096; GO:0030478; GO:0015629; GO:0008356; GO:0007411; GO:0042995; GO:0042384; GO:0005737; GO:0016482; GO:0005829; GO:0048013; GO:0007163; GO:0070062; GO:0005925; GO:0045087; GO:0016344; GO:0033206; GO:0016020; GO:0006928; GO:0007264; GO:0051653; GO:0005200	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9000076}. Cell projection {ECO:0000269|PubMed:9000076}.	ATP-binding; Acetylation; Actin-binding; Alternative splicing; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Nucleotide-binding; Reference proteome	Alternative sequence (1); Chain (1); Modified residue (2); Nucleotide binding (3); Sequence conflict (2)
CNDG2_HUMAN	Q86XI2	CNDG2_HUMAN	reviewed	Condensin-2 complex subunit G2 (Chromosome-associated protein G2) (CAP-G2) (hCAP-G2) (Leucine zipper protein 5) (Non-SMC condensin II complex subunit G2)	NCAPG2 LUZP5	Homo sapiens (Human)	1143	membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; methylated histone binding [GO:0035064]; cell division [GO:0051301]; chromosome condensation [GO:0030261]; inner cell mass cell proliferation [GO:0001833]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]	cell division [GO:0051301]; chromosome condensation [GO:0030261]; inner cell mass cell proliferation [GO:0001833]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]	methylated histone binding [GO:0035064]	membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0051301; GO:0030261; GO:0001833; GO:0016020; GO:0035064; GO:0000278; GO:0007067; GO:0005654; GO:0005634	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14532007}.	Alternative splicing; Cell cycle; Cell division; Complete proteome; DNA condensation; Mitosis; Nucleus; Phosphoprotein; Polymorphism; Reference proteome	Alternative sequence (1); Chain (1); Erroneous initiation (3); Modified residue (3); Natural variant (2); Repeat (1); Sequence conflict (1)
PML_HUMAN	P29590	PML_HUMAN	reviewed	Protein PML (Promyelocytic leukemia protein) (RING finger protein 71) (Tripartite motif-containing protein 19)	PML MYL PP8675 RNF71 TRIM19	Homo sapiens (Human)	882	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; extrinsic component of endoplasmic reticulum membrane [GO:0042406]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; cobalt ion binding [GO:0050897]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; SUMO binding [GO:0032183]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cell cycle arrest [GO:0007050]; cell fate commitment [GO:0045165]; cellular protein metabolic process [GO:0044267]; cellular response to interleukin-4 [GO:0071353]; cellular senescence [GO:0090398]; circadian regulation of gene expression [GO:0032922]; common-partner SMAD protein phosphorylation [GO:0007182]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; entrainment of circadian clock by photoperiod [GO:0043153]; extrinsic apoptotic signaling pathway [GO:0097191]; innate immune response [GO:0045087]; interferon-gamma-mediated signaling pathway [GO:0060333]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; maintenance of protein location in nucleus [GO:0051457]; myeloid cell differentiation [GO:0030099]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell growth [GO:0030308]; negative regulation of cell proliferation [GO:0008285]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000059]; negative regulation of telomerase activity [GO:0051974]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of translation in response to oxidative stress [GO:0032938]; negative regulation of viral release from host cell [GO:1902187]; PML body organization [GO:0030578]; positive regulation of apoptotic process involved in mammary gland involution [GO:0060058]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of histone deacetylation [GO:0031065]; post-translational protein modification [GO:0043687]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein complex assembly [GO:0006461]; protein stabilization [GO:0050821]; protein sumoylation [GO:0016925]; protein targeting [GO:0006605]; regulation of calcium ion transport into cytosol [GO:0010522]; regulation of circadian rhythm [GO:0042752]; regulation of double-strand break repair [GO:2000779]; regulation of MHC class I biosynthetic process [GO:0045343]; regulation of protein phosphorylation [GO:0001932]; regulation of transcription, DNA-templated [GO:0006355]; response to cytokine [GO:0034097]; response to gamma radiation [GO:0010332]; response to hypoxia [GO:0001666]; response to UV [GO:0009411]; retinoic acid receptor signaling pathway [GO:0048384]; SMAD protein import into nucleus [GO:0007184]; transcription, DNA-templated [GO:0006351]; transforming growth factor beta receptor signaling pathway [GO:0007179]; viral process [GO:0016032]	activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cell cycle arrest [GO:0007050]; cell fate commitment [GO:0045165]; cellular protein metabolic process [GO:0044267]; cellular response to interleukin-4 [GO:0071353]; cellular senescence [GO:0090398]; circadian regulation of gene expression [GO:0032922]; common-partner SMAD protein phosphorylation [GO:0007182]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; entrainment of circadian clock by photoperiod [GO:0043153]; extrinsic apoptotic signaling pathway [GO:0097191]; innate immune response [GO:0045087]; interferon-gamma-mediated signaling pathway [GO:0060333]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; maintenance of protein location in nucleus [GO:0051457]; myeloid cell differentiation [GO:0030099]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell growth [GO:0030308]; negative regulation of cell proliferation [GO:0008285]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000059]; negative regulation of telomerase activity [GO:0051974]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of translation in response to oxidative stress [GO:0032938]; negative regulation of viral release from host cell [GO:1902187]; PML body organization [GO:0030578]; positive regulation of apoptotic process involved in mammary gland involution [GO:0060058]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of histone deacetylation [GO:0031065]; post-translational protein modification [GO:0043687]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein complex assembly [GO:0006461]; protein stabilization [GO:0050821]; protein sumoylation [GO:0016925]; protein targeting [GO:0006605]; regulation of calcium ion transport into cytosol [GO:0010522]; regulation of circadian rhythm [GO:0042752]; regulation of double-strand break repair [GO:2000779]; regulation of MHC class I biosynthetic process [GO:0045343]; regulation of protein phosphorylation [GO:0001932]; regulation of transcription, DNA-templated [GO:0006355]; response to cytokine [GO:0034097]; response to gamma radiation [GO:0010332]; response to hypoxia [GO:0001666]; response to UV [GO:0009411]; retinoic acid receptor signaling pathway [GO:0048384]; SMAD protein import into nucleus [GO:0007184]; transcription, DNA-templated [GO:0006351]; transforming growth factor beta receptor signaling pathway [GO:0007179]; viral process [GO:0016032]	cobalt ion binding [GO:0050897]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; SUMO binding [GO:0032183]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; extrinsic component of endoplasmic reticulum membrane [GO:0042406]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	GO:0003677; GO:0006977; GO:0016605; GO:0030578; GO:0007184; GO:0032183; GO:0006919; GO:0006915; GO:0060444; GO:0007050; GO:0045165; GO:0044267; GO:0071353; GO:0090398; GO:0032922; GO:0050897; GO:0007182; GO:0019221; GO:0005737; GO:0005829; GO:0051607; GO:0031901; GO:0032469; GO:0043153; GO:0097191; GO:0042406; GO:0045087; GO:0060333; GO:0008630; GO:0042771; GO:0070059; GO:0008631; GO:0051457; GO:0030099; GO:0016525; GO:0030308; GO:0008285; GO:0045930; GO:2000059; GO:0051974; GO:0032211; GO:0045892; GO:0032938; GO:1902187; GO:0016363; GO:0031965; GO:0005730; GO:0005654; GO:0005634; GO:0060058; GO:0002230; GO:2001238; GO:0031065; GO:0043687; GO:0043161; GO:0006461; GO:0046982; GO:0042803; GO:0050821; GO:0016925; GO:0006605; GO:0045343; GO:0010522; GO:0042752; GO:2000779; GO:0001932; GO:0006355; GO:0009411; GO:0034097; GO:0010332; GO:0001666; GO:0048384; GO:0003713; GO:0006351; GO:0007179; GO:0031625; GO:0016032; GO:0008270	SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleoplasm. Cytoplasm. Nucleus, PML body. Nucleus, nucleolus. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Isoform PML-1 can shuttle between the nucleus and cytoplasm. Isoform PML-2, isoform PML-3, isoform PML-4, isoform PML-5 and isoform PML-6 are nuclear isoforms whereas isoform PML-7 and isoform PML-14 lacking the nuclear localization signal are cytoplasmic isoforms. Detected in the nucleolus after DNA damage. Acetylation at Lys-487 is essential for its nuclear localization. Within the nucleus, most of PML is expressed in the diffuse nuclear fraction of the nucleoplasm and only a small fraction is found in the matrix-associated nuclear bodies (PML-NBs). The transfer of PML from the nucleoplasm to PML-NBs depends on its phosphorylation and sumoylation. The B1 box and the RING finger are also required for the localization in PML-NBs. Also found in specific membrane structures termed mitochondria-associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria. Sequestered in the cytoplasm by interaction with rabies virus phosphoprotein.	3D-structure; Acetylation; Activator; Alternative splicing; Antiviral defense; Apoptosis; Biological rhythms; Chromosomal rearrangement; Coiled coil; Complete proteome; Cytoplasm; DNA-binding; Endoplasmic reticulum; Endosome; Host-virus interaction; Immunity; Innate immunity; Isopeptide bond; Membrane; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Proto-oncogene; Reference proteome; Repeat; Transcription; Transcription regulation; Tumor suppressor; Ubl conjugation; Zinc; Zinc-finger	Alternative sequence (15); Beta strand (7); Chain (1); Coiled coil (1); Compositional bias (1); Cross-link (8); Erroneous initiation (5); Helix (2); Metal binding (8); Modified residue (18); Motif (1); Mutagenesis (16); Natural variant (1); Region (2); Sequence caution (1); Sequence conflict (12); Site (2); Turn (2); Zinc finger (3)
LYAR_HUMAN	Q9NX58	LYAR_HUMAN	reviewed	Cell growth-regulating nucleolar protein	LYAR PNAS-5	Homo sapiens (Human)	379	nucleolus [GO:0005730]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; poly(A) RNA binding [GO:0044822]		metal ion binding [GO:0046872]; poly(A) RNA binding [GO:0044822]	nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0046872; GO:0005730; GO:0005634; GO:0044822	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.	Coiled coil; Complete proteome; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Zinc; Zinc-finger	Chain (1); Coiled coil (1); Compositional bias (1); Metal binding (8); Modified residue (2); Natural variant (2); Sequence conflict (1); Zinc finger (2)
ML12B_HUMAN	O14950	ML12B_HUMAN	reviewed	Myosin regulatory light chain 12B (MLC-2A) (MLC-2) (Myosin regulatory light chain 2-B, smooth muscle isoform) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2) (SHUJUN-1)	MYL12B MRLC2 MYLC2B	Homo sapiens (Human)	172	apical part of cell [GO:0045177]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; myosin II complex [GO:0016460]; stress fiber [GO:0001725]; Z disc [GO:0030018]; calcium ion binding [GO:0005509]; axon guidance [GO:0007411]; ephrin receptor signaling pathway [GO:0048013]; muscle contraction [GO:0006936]; regulation of cell shape [GO:0008360]; small GTPase mediated signal transduction [GO:0007264]	axon guidance [GO:0007411]; ephrin receptor signaling pathway [GO:0048013]; muscle contraction [GO:0006936]; regulation of cell shape [GO:0008360]; small GTPase mediated signal transduction [GO:0007264]	calcium ion binding [GO:0005509]	apical part of cell [GO:0045177]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; myosin II complex [GO:0016460]; stress fiber [GO:0001725]; Z disc [GO:0030018]	GO:0030018; GO:0045177; GO:0007411; GO:0005509; GO:0005829; GO:0048013; GO:0070062; GO:0006936; GO:0016460; GO:0008360; GO:0007264; GO:0001725		Calcium; Complete proteome; Metal-binding; Motor protein; Muscle protein; Myosin; Phosphoprotein; Polymorphism; Reference proteome; Repeat	Calcium binding (1); Chain (1); Domain (3); Frameshift (1); Modified residue (2); Mutagenesis (2); Natural variant (1); Sequence conflict (4)
SYSC_HUMAN	P49591	SYSC_HUMAN	reviewed	Serine--tRNA ligase, cytoplasmic (EC 6.1.1.11) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase)	SARS SERS	Homo sapiens (Human)	514	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; RNA binding [GO:0003723]; serine-tRNA ligase activity [GO:0004828]; gene expression [GO:0010467]; selenocysteinyl-tRNA(Sec) biosynthetic process [GO:0097056]; seryl-tRNA aminoacylation [GO:0006434]; translation [GO:0006412]; tRNA aminoacylation for protein translation [GO:0006418]; tRNA processing [GO:0008033]	gene expression [GO:0010467]; selenocysteinyl-tRNA(Sec) biosynthetic process [GO:0097056]; seryl-tRNA aminoacylation [GO:0006434]; translation [GO:0006412]; tRNA aminoacylation for protein translation [GO:0006418]; tRNA processing [GO:0008033]	ATP binding [GO:0005524]; RNA binding [GO:0003723]; serine-tRNA ligase activity [GO:0004828]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]	GO:0005524; GO:0003723; GO:0005737; GO:0005829; GO:0070062; GO:0010467; GO:0005739; GO:0097056; GO:0004828; GO:0006434; GO:0006418; GO:0008033; GO:0006412	SUBCELLULAR LOCATION: Cytoplasm.	3D-structure; ATP-binding; Acetylation; Aminoacyl-tRNA synthetase; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding; Phosphoprotein; Protein biosynthesis; Reference proteome	Beta strand (21); Binding site (3); Chain (1); Helix (21); Modified residue (3); Nucleotide binding (2); Region (1); Sequence conflict (2); Turn (3)
ASNS_HUMAN	P08243	ASNS_HUMAN	reviewed	Asparagine synthetase [glutamine-hydrolyzing] (EC 6.3.5.4) (Cell cycle control protein TS11) (Glutamine-dependent asparagine synthetase)	ASNS TS11	Homo sapiens (Human)	561	cytosol [GO:0005829]; asparagine synthase (glutamine-hydrolyzing) activity [GO:0004066]; ATP binding [GO:0005524]; cofactor binding [GO:0048037]; asparagine biosynthetic process [GO:0006529]; cellular amino acid biosynthetic process [GO:0008652]; cellular nitrogen compound metabolic process [GO:0034641]; cellular protein metabolic process [GO:0044267]; cellular response to glucose starvation [GO:0042149]; cellular response to hormone stimulus [GO:0032870]; endoplasmic reticulum unfolded protein response [GO:0030968]; glutamine metabolic process [GO:0006541]; L-asparagine biosynthetic process [GO:0070981]; liver development [GO:0001889]; negative regulation of apoptotic process [GO:0043066]; PERK-mediated unfolded protein response [GO:0036499]; positive regulation of mitotic cell cycle [GO:0045931]; response to amino acid [GO:0043200]; response to follicle-stimulating hormone [GO:0032354]; response to light stimulus [GO:0009416]; response to mechanical stimulus [GO:0009612]; response to methotrexate [GO:0031427]; response to toxic substance [GO:0009636]; small molecule metabolic process [GO:0044281]	asparagine biosynthetic process [GO:0006529]; cellular amino acid biosynthetic process [GO:0008652]; cellular nitrogen compound metabolic process [GO:0034641]; cellular protein metabolic process [GO:0044267]; cellular response to glucose starvation [GO:0042149]; cellular response to hormone stimulus [GO:0032870]; endoplasmic reticulum unfolded protein response [GO:0030968]; glutamine metabolic process [GO:0006541]; L-asparagine biosynthetic process [GO:0070981]; liver development [GO:0001889]; negative regulation of apoptotic process [GO:0043066]; PERK-mediated unfolded protein response [GO:0036499]; positive regulation of mitotic cell cycle [GO:0045931]; response to amino acid [GO:0043200]; response to follicle-stimulating hormone [GO:0032354]; response to light stimulus [GO:0009416]; response to mechanical stimulus [GO:0009612]; response to methotrexate [GO:0031427]; response to toxic substance [GO:0009636]; small molecule metabolic process [GO:0044281]	asparagine synthase (glutamine-hydrolyzing) activity [GO:0004066]; ATP binding [GO:0005524]; cofactor binding [GO:0048037]	cytosol [GO:0005829]	GO:0005524; GO:0070981; GO:0036499; GO:0006529; GO:0004066; GO:0008652; GO:0034641; GO:0044267; GO:0042149; GO:0032870; GO:0048037; GO:0005829; GO:0030968; GO:0006541; GO:0001889; GO:0043066; GO:0045931; GO:0043200; GO:0032354; GO:0009416; GO:0009612; GO:0031427; GO:0009636; GO:0044281		ATP-binding; Acetylation; Alternative splicing; Amino-acid biosynthesis; Asparagine biosynthesis; Complete proteome; Disease mutation; Glutamine amidotransferase; Ligase; Mental retardation; Nucleotide-binding; Polymorphism; Reference proteome	Active site (1); Alternative sequence (2); Binding site (3); Chain (1); Domain (2); Initiator methionine (1); Modified residue (1); Mutagenesis (1); Natural variant (4); Nucleotide binding (1); Region (2); Sequence conflict (5); Site (1)
DCD_HUMAN	P81605	DCD_HUMAN	reviewed	Dermcidin (EC 3.4.-.-) (Preproteolysin) [Cleaved into: Survival-promoting peptide; DCD-1]	DCD AIDD DSEP	Homo sapiens (Human)	110	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; peptidase activity [GO:0008233]; poly(A) RNA binding [GO:0044822]; defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; killing of cells of other organism [GO:0031640]	defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; killing of cells of other organism [GO:0031640]	peptidase activity [GO:0008233]; poly(A) RNA binding [GO:0044822]	extracellular exosome [GO:0070062]; extracellular region [GO:0005576]	GO:0042742; GO:0050832; GO:0070062; GO:0005576; GO:0031640; GO:0008233; GO:0044822	SUBCELLULAR LOCATION: Secreted.	3D-structure; Acetylation; Alternative splicing; Antibiotic; Antimicrobial; Complete proteome; Direct protein sequencing; Fungicide; Hydrolase; Manganese; Protease; Reference proteome; Secreted; Signal	Alternative sequence (3); Chain (1); Helix (1); Mass spectrometry (1); Modified residue (1); Peptide (2); Propeptide (2); Signal peptide (1)
CALR_HUMAN	P27797	CALR_HUMAN	reviewed	Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60)	CALR CRTC	Homo sapiens (Human)	417	acrosomal vesicle [GO:0001669]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle lumen [GO:0071682]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; integral component of lumenal side of endoplasmic reticulum membrane [GO:0071556]; intracellular [GO:0005622]; membrane [GO:0016020]; MHC class I peptide loading complex [GO:0042824]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; polysome [GO:0005844]; proteinaceous extracellular matrix [GO:0005578]; sarcoplasmic reticulum lumen [GO:0033018]; smooth endoplasmic reticulum [GO:0005790]; androgen receptor binding [GO:0050681]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; chaperone binding [GO:0051087]; complement component C1q binding [GO:0001849]; DNA binding [GO:0003677]; glycoprotein binding [GO:0001948]; hormone binding [GO:0042562]; integrin binding [GO:0005178]; iron ion binding [GO:0005506]; mRNA binding [GO:0003729]; peptide binding [GO:0042277]; poly(A) RNA binding [GO:0044822]; protein binding involved in protein folding [GO:0044183]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]; zinc ion binding [GO:0008270]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; ATF6-mediated unfolded protein response [GO:0036500]; cardiac muscle cell differentiation [GO:0055007]; cell cycle arrest [GO:0007050]; cellular calcium ion homeostasis [GO:0006874]; cellular protein metabolic process [GO:0044267]; cellular response to lithium ion [GO:0071285]; cellular senescence [GO:0090398]; chaperone-mediated protein folding [GO:0061077]; cortical actin cytoskeleton organization [GO:0030866]; endoplasmic reticulum unfolded protein response [GO:0030968]; glucocorticoid receptor signaling pathway [GO:0042921]; negative regulation of intracellular steroid hormone receptor signaling pathway [GO:0033144]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of translation [GO:0017148]; peptide antigen assembly with MHC class I protein complex [GO:0002502]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell proliferation [GO:0008284]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of DNA replication [GO:0045740]; positive regulation of gene expression [GO:0010628]; positive regulation of phagocytosis [GO:0050766]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; post-translational protein modification [GO:0043687]; protein export from nucleus [GO:0006611]; protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]; protein localization to nucleus [GO:0034504]; protein maturation by protein folding [GO:0022417]; protein N-linked glycosylation via asparagine [GO:0018279]; protein stabilization [GO:0050821]; receptor-mediated endocytosis [GO:0006898]; regulation of apoptotic process [GO:0042981]; regulation of meiotic nuclear division [GO:0040020]; regulation of transcription, DNA-templated [GO:0006355]; response to drug [GO:0042493]; response to estradiol [GO:0032355]; response to testosterone [GO:0033574]; sequestering of calcium ion [GO:0051208]; spermatogenesis [GO:0007283]	antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; ATF6-mediated unfolded protein response [GO:0036500]; cardiac muscle cell differentiation [GO:0055007]; cell cycle arrest [GO:0007050]; cellular calcium ion homeostasis [GO:0006874]; cellular protein metabolic process [GO:0044267]; cellular response to lithium ion [GO:0071285]; cellular senescence [GO:0090398]; chaperone-mediated protein folding [GO:0061077]; cortical actin cytoskeleton organization [GO:0030866]; endoplasmic reticulum unfolded protein response [GO:0030968]; glucocorticoid receptor signaling pathway [GO:0042921]; negative regulation of intracellular steroid hormone receptor signaling pathway [GO:0033144]; negative regulation of neuron differentiation [GO:0045665]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of translation [GO:0017148]; peptide antigen assembly with MHC class I protein complex [GO:0002502]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell proliferation [GO:0008284]; positive regulation of dendritic cell chemotaxis [GO:2000510]; positive regulation of DNA replication [GO:0045740]; positive regulation of gene expression [GO:0010628]; positive regulation of phagocytosis [GO:0050766]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; post-translational protein modification [GO:0043687]; protein export from nucleus [GO:0006611]; protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]; protein localization to nucleus [GO:0034504]; protein maturation by protein folding [GO:0022417]; protein N-linked glycosylation via asparagine [GO:0018279]; protein stabilization [GO:0050821]; receptor-mediated endocytosis [GO:0006898]; regulation of apoptotic process [GO:0042981]; regulation of meiotic nuclear division [GO:0040020]; regulation of transcription, DNA-templated [GO:0006355]; response to drug [GO:0042493]; response to estradiol [GO:0032355]; response to testosterone [GO:0033574]; sequestering of calcium ion [GO:0051208]; spermatogenesis [GO:0007283]	androgen receptor binding [GO:0050681]; calcium ion binding [GO:0005509]; carbohydrate binding [GO:0030246]; chaperone binding [GO:0051087]; complement component C1q binding [GO:0001849]; DNA binding [GO:0003677]; glycoprotein binding [GO:0001948]; hormone binding [GO:0042562]; integrin binding [GO:0005178]; iron ion binding [GO:0005506]; mRNA binding [GO:0003729]; peptide binding [GO:0042277]; poly(A) RNA binding [GO:0044822]; protein binding involved in protein folding [GO:0044183]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]; zinc ion binding [GO:0008270]	acrosomal vesicle [GO:0001669]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle lumen [GO:0071682]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; integral component of lumenal side of endoplasmic reticulum membrane [GO:0071556]; intracellular [GO:0005622]; membrane [GO:0016020]; MHC class I peptide loading complex [GO:0042824]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; polysome [GO:0005844]; proteinaceous extracellular matrix [GO:0005578]; sarcoplasmic reticulum lumen [GO:0033018]; smooth endoplasmic reticulum [GO:0005790]	GO:0036500; GO:0003677; GO:0005794; GO:0042824; GO:0001669; GO:0050681; GO:0042590; GO:0002479; GO:0002474; GO:0005509; GO:0030246; GO:0055007; GO:0007050; GO:0009986; GO:0006874; GO:0044267; GO:0071285; GO:0090398; GO:0051087; GO:0061077; GO:0001849; GO:0030866; GO:0005737; GO:0005829; GO:0071682; GO:0005783; GO:0005788; GO:0030968; GO:0009897; GO:0070062; GO:0005576; GO:0005615; GO:0005925; GO:0042921; GO:0001948; GO:0042562; GO:0071556; GO:0005178; GO:0005622; GO:0005506; GO:0003729; GO:0016020; GO:0033144; GO:0045665; GO:0048387; GO:0000122; GO:0045892; GO:0017148; GO:0005634; GO:0002502; GO:0042277; GO:0048471; GO:0044822; GO:0005844; GO:0045740; GO:0045787; GO:0008284; GO:2000510; GO:0010628; GO:0050766; GO:1900026; GO:0043687; GO:0018279; GO:0044183; GO:0006611; GO:0006457; GO:0034975; GO:0034504; GO:0022417; GO:0050821; GO:0005578; GO:0006898; GO:0042981; GO:0040020; GO:0006355; GO:0042493; GO:0032355; GO:0033574; GO:0033018; GO:0051208; GO:0005790; GO:0007283; GO:0031625; GO:0051082; GO:0008270	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen. Cytoplasm, cytosol. Secreted, extracellular space, extracellular matrix. Cell surface. Sarcoplasmic reticulum lumen {ECO:0000250}. Note=Also found in cell surface (T cells), cytosol and extracellular matrix. Associated with the lytic granules in the cytolytic T-lymphocytes.	3D-structure; Acetylation; Calcium; Chaperone; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; Endoplasmic reticulum; Extracellular matrix; Glycoprotein; Lectin; Metal-binding; Reference proteome; Repeat; Sarcoplasmic reticulum; Secreted; Signal; Zinc	Beta strand (18); Binding site (5); Chain (1); Compositional bias (1); Disulfide bond (1); Glycosylation (1); Helix (5); Mass spectrometry (1); Metal binding (4); Modified residue (3); Motif (1); Region (6); Repeat (7); Signal peptide (1); Turn (1)
B4DJV5_HUMAN	B4DJV5	B4DJV5_HUMAN	unreviewed	Periodic tryptophan protein 1 homolog (cDNA FLJ51513, highly similar to Periodic tryptophan protein 1 homolog)	PWP1	Homo sapiens (Human)	439	Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]			Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]	GO:0005794; GO:0005730		Complete proteome; Proteomics identification; Reference proteome; Repeat; WD repeat	
PWP1_HUMAN	Q13610	PWP1_HUMAN	reviewed	Periodic tryptophan protein 1 homolog (Keratinocyte protein IEF SSP 9502)	PWP1	Homo sapiens (Human)	501	Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleus [GO:0005634]; transcription, DNA-templated [GO:0006351]	transcription, DNA-templated [GO:0006351]		Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0005794; GO:0005730; GO:0005634; GO:0006351	SUBCELLULAR LOCATION: Nucleus.	Alternative splicing; Complete proteome; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; WD repeat	Alternative sequence (2); Chain (1); Modified residue (5); Natural variant (1); Repeat (7)
SMD1_HUMAN	P62314	SMD1_HUMAN	reviewed	Small nuclear ribonucleoprotein Sm D1 (Sm-D1) (Sm-D autoantigen) (snRNP core protein D1)	SNRPD1	Homo sapiens (Human)	119	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pICln-Sm protein complex [GO:0034715]; small nuclear ribonucleoprotein complex [GO:0030532]; SMN-Sm protein complex [GO:0034719]; U1 snRNP [GO:0005685]; U12-type spliceosomal complex [GO:0005689]; U4 snRNP [GO:0005687]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; activation of mitophagy in response to mitochondrial depolarization [GO:0098779]; gene expression [GO:0010467]; mRNA splicing, via spliceosome [GO:0000398]; ncRNA metabolic process [GO:0034660]; positive regulation of defense response to virus by host [GO:0002230]; RNA splicing [GO:0008380]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]	activation of mitophagy in response to mitochondrial depolarization [GO:0098779]; gene expression [GO:0010467]; mRNA splicing, via spliceosome [GO:0000398]; ncRNA metabolic process [GO:0034660]; positive regulation of defense response to virus by host [GO:0002230]; RNA splicing [GO:0008380]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]	poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pICln-Sm protein complex [GO:0034715]; small nuclear ribonucleoprotein complex [GO:0030532]; SMN-Sm protein complex [GO:0034719]; U12-type spliceosomal complex [GO:0005689]; U1 snRNP [GO:0005685]; U4 snRNP [GO:0005687]	GO:0003723; GO:0008380; GO:0034719; GO:0005685; GO:0005689; GO:0005687; GO:0098779; GO:0071013; GO:0005829; GO:0010467; GO:0000398; GO:0034709; GO:0034660; GO:0005654; GO:0005634; GO:0034715; GO:0044822; GO:0002230; GO:0030532; GO:0000245; GO:0000387	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:18984161}. Nucleus {ECO:0000269|PubMed:18984161}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.	3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Methylation; Nucleus; Reference proteome; Repeat; Ribonucleoprotein; Spliceosome; mRNA processing; mRNA splicing	Beta strand (5); Chain (1); Compositional bias (1); Helix (3); Mutagenesis (2); Region (1)
TCPA_HUMAN	P17987	TCPA_HUMAN	reviewed	T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha)	TCP1 CCT1 CCTA	Homo sapiens (Human)	556	acrosomal vesicle [GO:0001669]; cell body [GO:0044297]; centrosome [GO:0005813]; chaperonin-containing T-complex [GO:0005832]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; nuclear heterochromatin [GO:0005720]; pericentriolar material [GO:0000242]; zona pellucida receptor complex [GO:0002199]; ATP binding [GO:0005524]; poly(A) RNA binding [GO:0044822]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]; 'de novo' posttranslational protein folding [GO:0051084]; binding of sperm to zona pellucida [GO:0007339]; cellular protein metabolic process [GO:0044267]; protein folding [GO:0006457]; regulation of macrophage apoptotic process [GO:2000109]; toxin transport [GO:1901998]; translocation of peptides or proteins into host cell cytoplasm [GO:0044053]; tubulin complex assembly [GO:0007021]	'de novo' posttranslational protein folding [GO:0051084]; binding of sperm to zona pellucida [GO:0007339]; cellular protein metabolic process [GO:0044267]; protein folding [GO:0006457]; regulation of macrophage apoptotic process [GO:2000109]; toxin transport [GO:1901998]; translocation of peptides or proteins into host cell cytoplasm [GO:0044053]; tubulin complex assembly [GO:0007021]	ATP binding [GO:0005524]; poly(A) RNA binding [GO:0044822]; ubiquitin protein ligase binding [GO:0031625]; unfolded protein binding [GO:0051082]	acrosomal vesicle [GO:0001669]; cell body [GO:0044297]; centrosome [GO:0005813]; chaperonin-containing T-complex [GO:0005832]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; microtubule [GO:0005874]; nuclear heterochromatin [GO:0005720]; pericentriolar material [GO:0000242]; zona pellucida receptor complex [GO:0002199]	GO:0051084; GO:0005524; GO:0005794; GO:0001669; GO:0007339; GO:0044297; GO:0044267; GO:0005813; GO:0005832; GO:0005829; GO:0070062; GO:0005874; GO:0005720; GO:0000242; GO:0044822; GO:0006457; GO:2000109; GO:1901998; GO:0044053; GO:0007021; GO:0031625; GO:0051082; GO:0002199	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.	ATP-binding; Acetylation; Chaperone; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome	Chain (1); Modified residue (8); Natural variant (1); Sequence conflict (2)
K7ELL7_HUMAN	K7ELL7	K7ELL7_HUMAN	unreviewed	Glucosidase 2 subunit beta	PRKCSH	Homo sapiens (Human)	535	endoplasmic reticulum [GO:0005783]; calcium ion binding [GO:0005509]; RNA binding [GO:0003723]; in utero embryonic development [GO:0001701]; liver development [GO:0001889]; N-glycan processing [GO:0006491]; negative regulation of neuron projection development [GO:0010977]; nitrogen compound metabolic process [GO:0006807]; protein heterooligomerization [GO:0051291]; renal system development [GO:0072001]	in utero embryonic development [GO:0001701]; liver development [GO:0001889]; negative regulation of neuron projection development [GO:0010977]; N-glycan processing [GO:0006491]; nitrogen compound metabolic process [GO:0006807]; protein heterooligomerization [GO:0051291]; renal system development [GO:0072001]	calcium ion binding [GO:0005509]; RNA binding [GO:0003723]	endoplasmic reticulum [GO:0005783]	GO:0006491; GO:0003723; GO:0005509; GO:0005783; GO:0001701; GO:0001889; GO:0010977; GO:0006807; GO:0051291; GO:0072001		Calcium; Complete proteome; Proteomics identification; Reference proteome	
GNL1_HUMAN	P36915	GNL1_HUMAN	reviewed	Guanine nucleotide-binding protein-like 1 (GTP-binding protein HSR1)	GNL1 HSR1	Homo sapiens (Human)	607	extracellular space [GO:0005615]; nucleus [GO:0005634]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; structural molecule activity [GO:0005198]; cellular response to DNA damage stimulus [GO:0006974]; metabolic process [GO:0008152]; ribosome biogenesis [GO:0042254]; signal transduction [GO:0007165]; T cell mediated immunity [GO:0002456]	cellular response to DNA damage stimulus [GO:0006974]; metabolic process [GO:0008152]; ribosome biogenesis [GO:0042254]; signal transduction [GO:0007165]; T cell mediated immunity [GO:0002456]	GTPase activity [GO:0003924]; GTP binding [GO:0005525]; structural molecule activity [GO:0005198]	extracellular space [GO:0005615]; nucleus [GO:0005634]	GO:0005525; GO:0003924; GO:0002456; GO:0006974; GO:0005615; GO:0008152; GO:0005634; GO:0042254; GO:0007165; GO:0005198		Alternative splicing; Complete proteome; GTP-binding; Nucleotide-binding; Phosphoprotein; Reference proteome	Alternative sequence (2); Chain (1); Compositional bias (1); Domain (1); Modified residue (11); Nucleotide binding (3); Sequence conflict (4)
SSBP_HUMAN	Q04837	SSBP_HUMAN	reviewed	Single-stranded DNA-binding protein, mitochondrial (Mt-SSB) (MtSSB) (PWP1-interacting protein 17)	SSBP1 SSBP	Homo sapiens (Human)	148	extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; poly(A) RNA binding [GO:0044822]; single-stranded DNA binding [GO:0003697]; DNA replication [GO:0006260]; mitochondrion morphogenesis [GO:0070584]; mitochondrion organization [GO:0007005]; organelle organization [GO:0006996]; positive regulation of helicase activity [GO:0051096]	DNA replication [GO:0006260]; mitochondrion morphogenesis [GO:0070584]; mitochondrion organization [GO:0007005]; organelle organization [GO:0006996]; positive regulation of helicase activity [GO:0051096]	chromatin binding [GO:0003682]; poly(A) RNA binding [GO:0044822]; single-stranded DNA binding [GO:0003697]	extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleus [GO:0005634]	GO:0006260; GO:0003682; GO:0070062; GO:0005759; GO:0042645; GO:0005739; GO:0070584; GO:0007005; GO:0005634; GO:0006996; GO:0044822; GO:0051096; GO:0003697	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:18063578}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:18063578}.	3D-structure; Acetylation; Complete proteome; DNA replication; DNA-binding; Direct protein sequencing; Mitochondrion; Mitochondrion nucleoid; Phosphoprotein; Reference proteome; Transit peptide	Beta strand (8); Chain (1); Domain (1); Helix (1); Modified residue (3); Transit peptide (1)
HNRPM_HUMAN	P52272	HNRPM_HUMAN	reviewed	Heterogeneous nuclear ribonucleoprotein M (hnRNP M)	HNRNPM HNRPM NAGR1	Homo sapiens (Human)	730	catalytic step 2 spliceosome [GO:0071013]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; paraspeckles [GO:0042382]; spliceosomal complex [GO:0005681]; nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; alternative mRNA splicing, via spliceosome [GO:0000380]; gene expression [GO:0010467]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]	alternative mRNA splicing, via spliceosome [GO:0000380]; gene expression [GO:0010467]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]	nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; paraspeckles [GO:0042382]; spliceosomal complex [GO:0005681]	GO:0003723; GO:0008380; GO:0000380; GO:0071013; GO:0070062; GO:0031012; GO:0010467; GO:0005887; GO:0000398; GO:0016020; GO:0016363; GO:0005730; GO:0005654; GO:0000166; GO:0042382; GO:0044822; GO:0019904; GO:0005681	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|Ref.5}.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein; RNA-binding; Reference proteome; Repeat; Ribonucleoprotein; Spliceosome; Ubl conjugation; mRNA processing; mRNA splicing	Alternative sequence (1); Beta strand (8); Chain (1); Compositional bias (2); Domain (3); Helix (4); Initiator methionine (1); Modified residue (19); Region (1); Repeat (27); Sequence conflict (6); Turn (1)
B4DXP5_HUMAN	B4DXP5	B4DXP5_HUMAN		Merged into Q15366.											
EIF3G_HUMAN	O75821	EIF3G_HUMAN	reviewed	Eukaryotic translation initiation factor 3 subunit G (eIF3g) (Eukaryotic translation initiation factor 3 RNA-binding subunit) (eIF-3 RNA-binding subunit) (Eukaryotic translation initiation factor 3 subunit 4) (eIF-3-delta) (eIF3 p42) (eIF3 p44)	EIF3G EIF3S4	Homo sapiens (Human)	320	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; perinuclear region of cytoplasm [GO:0048471]; nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; translation initiation factor activity [GO:0003743]; cellular protein metabolic process [GO:0044267]; formation of translation preinitiation complex [GO:0001731]; gene expression [GO:0010467]; regulation of translational initiation [GO:0006446]; translation [GO:0006412]; translational initiation [GO:0006413]	cellular protein metabolic process [GO:0044267]; formation of translation preinitiation complex [GO:0001731]; gene expression [GO:0010467]; regulation of translational initiation [GO:0006446]; translation [GO:0006412]; translational initiation [GO:0006413]	nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; translation initiation factor activity [GO:0003743]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; perinuclear region of cytoplasm [GO:0048471]	GO:0044267; GO:0005737; GO:0005829; GO:0016282; GO:0033290; GO:0005852; GO:0001731; GO:0010467; GO:0000166; GO:0048471; GO:0044822; GO:0006446; GO:0006412; GO:0003743; GO:0006413	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03006}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03006, ECO:0000269|PubMed:17094969}. Cytoplasm, perinuclear region {ECO:0000255|HAMAP-Rule:MF_03006, ECO:0000269|PubMed:17094969}. Note=Colocalizes with AIFM1 in the nucleus and perinuclear region.	3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Initiation factor; Nucleus; Phosphoprotein; Protein biosynthesis; RNA-binding; Reference proteome	Beta strand (7); Chain (1); Domain (1); Helix (3); Initiator methionine (1); Mass spectrometry (2); Modified residue (5); Sequence conflict (1); Turn (2)
K7ENA8_HUMAN	K7ENA8	K7ENA8_HUMAN	unreviewed	Eukaryotic translation initiation factor 3 subunit G (Fragment)	EIF3G	Homo sapiens (Human)	289	cytoplasm [GO:0005737]; eukaryotic translation initiation factor 3 complex [GO:0005852]; nucleotide binding [GO:0000166]; translation initiation factor activity [GO:0003743]		nucleotide binding [GO:0000166]; translation initiation factor activity [GO:0003743]	cytoplasm [GO:0005737]; eukaryotic translation initiation factor 3 complex [GO:0005852]	GO:0005737; GO:0005852; GO:0000166; GO:0003743		Complete proteome; Cytoplasm; Initiation factor; Protein biosynthesis; Proteomics identification; RNA-binding; Reference proteome	Non-terminal residue (1)
EFGM_HUMAN	Q96RP9	EFGM_HUMAN	reviewed	Elongation factor G, mitochondrial (EF-Gmt) (Elongation factor G 1, mitochondrial) (mEF-G 1) (Elongation factor G1) (hEFG1)	GFM1 EFG EFG1 GFM	Homo sapiens (Human)	751	mitochondrial matrix [GO:0005759]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; poly(A) RNA binding [GO:0044822]; translation elongation factor activity [GO:0003746]; mitochondrial translation [GO:0032543]; mitochondrial translational elongation [GO:0070125]; organelle organization [GO:0006996]	mitochondrial translation [GO:0032543]; mitochondrial translational elongation [GO:0070125]; organelle organization [GO:0006996]	GTPase activity [GO:0003924]; GTP binding [GO:0005525]; poly(A) RNA binding [GO:0044822]; translation elongation factor activity [GO:0003746]	mitochondrial matrix [GO:0005759]	GO:0005525; GO:0003924; GO:0005759; GO:0032543; GO:0070125; GO:0006996; GO:0044822; GO:0003746	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03061}.	Acetylation; Alternative splicing; Complete proteome; Elongation factor; GTP-binding; Mitochondrion; Nucleotide-binding; Phosphoprotein; Polymorphism; Protein biosynthesis; Reference proteome; Transit peptide	Alternative sequence (1); Chain (1); Domain (1); Erroneous gene model prediction (1); Modified residue (2); Natural variant (3); Nucleotide binding (3); Sequence conflict (2); Transit peptide (1)
Q5T948_HUMAN	Q5T948	Q5T948_HUMAN	unreviewed	Serine/threonine-protein phosphatase 2A activator (EC 5.2.1.8) (Phosphotyrosyl phosphatase activator) (Fragment)	PPP2R4	Homo sapiens (Human)	254	cytoplasm [GO:0005737]; nucleus [GO:0005634]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; phosphatase activator activity [GO:0019211]; mitotic spindle organization in nucleus [GO:0030472]; protein peptidyl-prolyl isomerization [GO:0000413]	mitotic spindle organization in nucleus [GO:0030472]; protein peptidyl-prolyl isomerization [GO:0000413]	peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; phosphatase activator activity [GO:0019211]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005737; GO:0030472; GO:0005634; GO:0003755; GO:0019211; GO:0000413	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU361210}.	Complete proteome; Cytoplasm; Isomerase; Proteomics identification; Reference proteome; Rotamase	Non-terminal residue (1)
PLCG1_HUMAN	P19174	PLCG1_HUMAN	reviewed	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)	PLCG1 PLC1	Homo sapiens (Human)	1290	cell projection [GO:0042995]; cell-cell junction [GO:0005911]; COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; calcium ion binding [GO:0005509]; neurotrophin TRKA receptor binding [GO:0005168]; phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase C activity [GO:0004629]; protein kinase binding [GO:0019901]; receptor signaling protein activity [GO:0005057]; activation of MAPKK activity [GO:0000186]; activation of phospholipase C activity [GO:0007202]; axon guidance [GO:0007411]; blood coagulation [GO:0007596]; calcium-mediated signaling [GO:0019722]; cell migration [GO:0016477]; cellular response to epidermal growth factor stimulus [GO:0071364]; cytokine-mediated signaling pathway [GO:0019221]; epidermal growth factor receptor signaling pathway [GO:0007173]; Fc-epsilon receptor signaling pathway [GO:0038095]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; fibroblast growth factor receptor signaling pathway [GO:0008543]; in utero embryonic development [GO:0001701]; innate immune response [GO:0045087]; inositol phosphate metabolic process [GO:0043647]; leukocyte migration [GO:0050900]; neurotrophin TRK receptor signaling pathway [GO:0048011]; phospholipid catabolic process [GO:0009395]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; signal transduction [GO:0007165]; small molecule metabolic process [GO:0044281]; T cell receptor signaling pathway [GO:0050852]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; viral process [GO:0016032]	activation of MAPKK activity [GO:0000186]; activation of phospholipase C activity [GO:0007202]; axon guidance [GO:0007411]; blood coagulation [GO:0007596]; calcium-mediated signaling [GO:0019722]; cell migration [GO:0016477]; cellular response to epidermal growth factor stimulus [GO:0071364]; cytokine-mediated signaling pathway [GO:0019221]; epidermal growth factor receptor signaling pathway [GO:0007173]; Fc-epsilon receptor signaling pathway [GO:0038095]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; fibroblast growth factor receptor signaling pathway [GO:0008543]; innate immune response [GO:0045087]; inositol phosphate metabolic process [GO:0043647]; in utero embryonic development [GO:0001701]; leukocyte migration [GO:0050900]; neurotrophin TRK receptor signaling pathway [GO:0048011]; phospholipid catabolic process [GO:0009395]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; signal transduction [GO:0007165]; small molecule metabolic process [GO:0044281]; T cell receptor signaling pathway [GO:0050852]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; viral process [GO:0016032]	calcium ion binding [GO:0005509]; neurotrophin TRKA receptor binding [GO:0005168]; phosphatidylinositol phospholipase C activity [GO:0004435]; phospholipase C activity [GO:0004629]; protein kinase binding [GO:0019901]; receptor signaling protein activity [GO:0005057]	cell-cell junction [GO:0005911]; cell projection [GO:0042995]; COP9 signalosome [GO:0008180]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; ruffle [GO:0001726]	GO:0008180; GO:0038095; GO:0038096; GO:0050852; GO:0000186; GO:0007202; GO:0007411; GO:0007596; GO:0005509; GO:0019722; GO:0016477; GO:0042995; GO:0005911; GO:0071364; GO:0019221; GO:0005737; GO:0005829; GO:0007173; GO:0008543; GO:0001701; GO:0045087; GO:0043647; GO:0030027; GO:0050900; GO:0048011; GO:0005168; GO:0004435; GO:0004629; GO:0009395; GO:0005886; GO:0045766; GO:0043536; GO:0010634; GO:0051281; GO:0019901; GO:0005057; GO:0001726; GO:0007165; GO:0044281; GO:0048010; GO:0016032	SUBCELLULAR LOCATION: Cell projection, lamellipodium. Cell projection, ruffle. Note=Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment.	3D-structure; Acetylation; Alternative splicing; Calcium; Cell projection; Complete proteome; Host-virus interaction; Hydrolase; Lipid degradation; Lipid metabolism; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; SH2 domain; SH3 domain; Transducer; Ubl conjugation	Active site (2); Alternative sequence (1); Beta strand (20); Calcium binding (1); Chain (1); Domain (10); Helix (7); Initiator methionine (1); Modified residue (9); Natural variant (4); Turn (2)
SNUT2_HUMAN	Q53GS9	SNUT2_HUMAN	reviewed	U4/U6.U5 tri-snRNP-associated protein 2 (Inactive ubiquitin-specific peptidase 39) (SAD1 homolog) (U4/U6.U5 tri-snRNP-associated 65 kDa protein) (65K)	USP39 CGI-21 HSPC332 PRO2855	Homo sapiens (Human)	565	spliceosomal complex [GO:0005681]; ubiquitinyl hydrolase activity [GO:0036459]; zinc ion binding [GO:0008270]; cell cycle [GO:0007049]; cell division [GO:0051301]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]; spliceosomal complex assembly [GO:0000245]; ubiquitin-dependent protein catabolic process [GO:0006511]	cell cycle [GO:0007049]; cell division [GO:0051301]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]; spliceosomal complex assembly [GO:0000245]; ubiquitin-dependent protein catabolic process [GO:0006511]	ubiquitinyl hydrolase activity [GO:0036459]; zinc ion binding [GO:0008270]	spliceosomal complex [GO:0005681]	GO:0008380; GO:0007049; GO:0051301; GO:0006397; GO:0005681; GO:0000245; GO:0006511; GO:0036459; GO:0008270	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11350945}.	Alternative splicing; Cell cycle; Cell division; Complete proteome; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Spliceosome; Zinc; Zinc-finger; mRNA processing; mRNA splicing	Alternative sequence (3); Chain (1); Compositional bias (1); Domain (1); Erroneous initiation (1); Frameshift (1); Modified residue (1); Sequence conflict (7); Zinc finger (1)
B1AKJ5_HUMAN	B1AKJ5	B1AKJ5_HUMAN	unreviewed	Nardilysin (Nardilysin (N-arginine dibasic convertase), isoform CRA_d)	NRD1 hCG_40292	Homo sapiens (Human)	1219	mitochondrion [GO:0005739]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]		metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]	mitochondrion [GO:0005739]	GO:0046872; GO:0004222; GO:0005739		Complete proteome; Proteomics identification; Reference proteome	
NRDC_HUMAN	O43847	NRDC_HUMAN	reviewed	Nardilysin (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C)	NRD1	Homo sapiens (Human)	1150	cell surface [GO:0009986]; cytosol [GO:0005829]; epidermal growth factor binding [GO:0048408]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; cell migration [GO:0016477]; cell proliferation [GO:0008283]; neuromuscular junction development [GO:0007528]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; proteolysis [GO:0006508]; regulation of endopeptidase activity [GO:0052548]	cell migration [GO:0016477]; cell proliferation [GO:0008283]; neuromuscular junction development [GO:0007528]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; proteolysis [GO:0006508]; regulation of endopeptidase activity [GO:0052548]	epidermal growth factor binding [GO:0048408]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]	cell surface [GO:0009986]; cytosol [GO:0005829]	GO:0016477; GO:0008283; GO:0009986; GO:0005829; GO:0048408; GO:0046872; GO:0004222; GO:0007528; GO:0051044; GO:0006508; GO:0052548		Alternative splicing; Complete proteome; Hydrolase; Metal-binding; Metalloprotease; Phosphoprotein; Polymorphism; Protease; Reference proteome; Signal; Zinc	Active site (1); Alternative sequence (1); Chain (1); Compositional bias (2); Metal binding (3); Modified residue (2); Natural variant (2); Sequence conflict (11); Signal peptide (1)
PRS10_HUMAN	P62333	PRS10_HUMAN	reviewed	26S protease regulatory subunit 10B (26S proteasome AAA-ATPase subunit RPT4) (Proteasome 26S subunit ATPase 6) (Proteasome subunit p42)	PSMC6 SUG2	Homo sapiens (Human)	389	cytosol [GO:0005829]; cytosolic proteasome complex [GO:0031597]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear proteasome complex [GO:0031595]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; proteasome-activating ATPase activity [GO:0036402]; protein binding, bridging [GO:0030674]; TBP-class protein binding [GO:0017025]; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [GO:0045899]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; ubiquitin-dependent protein catabolic process [GO:0006511]; viral process [GO:0016032]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [GO:0045899]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; ubiquitin-dependent protein catabolic process [GO:0006511]; viral process [GO:0016032]	ATPase activity [GO:0016887]; ATP binding [GO:0005524]; proteasome-activating ATPase activity [GO:0036402]; protein binding, bridging [GO:0030674]; TBP-class protein binding [GO:0017025]	cytosol [GO:0005829]; cytosolic proteasome complex [GO:0031597]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear proteasome complex [GO:0031595]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]	GO:0005524; GO:0016887; GO:0006977; GO:0030433; GO:0000082; GO:0017025; GO:0031145; GO:0042590; GO:0002479; GO:0002474; GO:0006915; GO:0034641; GO:0005829; GO:0031597; GO:0070062; GO:0010467; GO:0045087; GO:0016020; GO:0000278; GO:0043066; GO:0090090; GO:0051436; GO:0031595; GO:0005654; GO:0005634; GO:0045899; GO:0090263; GO:1901800; GO:0051437; GO:0012501; GO:0022624; GO:0000502; GO:0008540; GO:0036402; GO:0030674; GO:0000209; GO:0042981; GO:0006521; GO:0051439; GO:0044281; GO:0002223; GO:0006511; GO:0016032	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.	ATP-binding; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleotide-binding; Nucleus; Proteasome; Reference proteome	Chain (1); Modified residue (2); Nucleotide binding (1); Sequence conflict (1)
ARP3_HUMAN	P61158	ARP3_HUMAN	reviewed	Actin-related protein 3 (Actin-like protein 3)	ACTR3 ARP3	Homo sapiens (Human)	418	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; Arp2/3 protein complex [GO:0005885]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; excitatory synapse [GO:0060076]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; hemidesmosome [GO:0030056]; lamellipodium [GO:0030027]; membrane [GO:0016020]; podosome [GO:0002102]; ATP binding [GO:0005524]; structural constituent of cytoskeleton [GO:0005200]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; asymmetric cell division [GO:0008356]; axon guidance [GO:0007411]; cilium morphogenesis [GO:0060271]; ephrin receptor signaling pathway [GO:0048013]; establishment or maintenance of cell polarity [GO:0007163]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; innate immune response [GO:0045087]; meiotic chromosome movement towards spindle pole [GO:0016344]; meiotic cytokinesis [GO:0033206]; movement of cell or subcellular component [GO:0006928]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of lamellipodium assembly [GO:0010592]; regulation of myosin II filament organization [GO:0043519]; response to antibiotic [GO:0046677]; response to carbohydrate [GO:0009743]; small GTPase mediated signal transduction [GO:0007264]; spindle localization [GO:0051653]	Arp2/3 complex-mediated actin nucleation [GO:0034314]; asymmetric cell division [GO:0008356]; axon guidance [GO:0007411]; cilium morphogenesis [GO:0060271]; ephrin receptor signaling pathway [GO:0048013]; establishment or maintenance of cell polarity [GO:0007163]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; innate immune response [GO:0045087]; meiotic chromosome movement towards spindle pole [GO:0016344]; meiotic cytokinesis [GO:0033206]; movement of cell or subcellular component [GO:0006928]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of lamellipodium assembly [GO:0010592]; regulation of myosin II filament organization [GO:0043519]; response to antibiotic [GO:0046677]; response to carbohydrate [GO:0009743]; small GTPase mediated signal transduction [GO:0007264]; spindle localization [GO:0051653]	ATP binding [GO:0005524]; structural constituent of cytoskeleton [GO:0005200]	actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; Arp2/3 protein complex [GO:0005885]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; excitatory synapse [GO:0060076]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; hemidesmosome [GO:0030056]; lamellipodium [GO:0030027]; membrane [GO:0016020]; podosome [GO:0002102]	GO:0005524; GO:0034314; GO:0005885; GO:0038096; GO:0000139; GO:0015629; GO:0005884; GO:0008356; GO:0007411; GO:0005911; GO:0060271; GO:0005829; GO:0048013; GO:0007163; GO:0060076; GO:0070062; GO:0005925; GO:0030056; GO:0045087; GO:0030027; GO:0016344; GO:0033206; GO:0016020; GO:0006928; GO:0002102; GO:0050775; GO:0051491; GO:0010592; GO:0043519; GO:0046677; GO:0009743; GO:0007264; GO:0051653; GO:0005200	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell projection. Note=In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes).	ATP-binding; Acetylation; Actin-binding; Cell projection; Cilium biogenesis/degradation; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Nucleotide-binding; Reference proteome	Chain (1); Initiator methionine (1); Modified residue (5)
PSB4_HUMAN	P28070	PSB4_HUMAN	reviewed	Proteasome subunit beta type-4 (EC 3.4.25.1) (26 kDa prosomal protein) (HsBPROS26) (PROS-26) (Macropain beta chain) (Multicatalytic endopeptidase complex beta chain) (Proteasome beta chain) (Proteasome chain 3) (HsN3)	PSMB4 PROS26	Homo sapiens (Human)	264	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; endopeptidase activity [GO:0004175]; lipopolysaccharide binding [GO:0001530]; threonine-type endopeptidase activity [GO:0004298]; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	endopeptidase activity [GO:0004175]; lipopolysaccharide binding [GO:0001530]; threonine-type endopeptidase activity [GO:0004298]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]	GO:0006977; GO:0000082; GO:0031145; GO:0042590; GO:0002479; GO:0002474; GO:0006915; GO:0034641; GO:0005737; GO:0005829; GO:0004175; GO:0070062; GO:0010467; GO:0045087; GO:0001530; GO:0000278; GO:0043066; GO:0090090; GO:0002862; GO:0051436; GO:0005654; GO:0005634; GO:0090263; GO:0051437; GO:0012501; GO:0010499; GO:0000502; GO:0005839; GO:0043161; GO:0000209; GO:0042981; GO:0006521; GO:0051439; GO:0044281; GO:0002223; GO:0004298; GO:0016032	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00809}. Nucleus {ECO:0000250}.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Host-virus interaction; Hydrolase; Nucleus; Phosphoprotein; Polymorphism; Protease; Proteasome; Reference proteome; Threonine protease; Zymogen	Active site (1); Beta strand (14); Chain (1); Helix (6); Modified residue (2); Natural variant (2); Propeptide (1); Sequence conflict (1); Turn (1)
PUR1_HUMAN	Q06203	PUR1_HUMAN	reviewed	Amidophosphoribosyltransferase (ATase) (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) (GPAT)	PPAT GPAT	Homo sapiens (Human)	517	cytosol [GO:0005829]; 4 iron, 4 sulfur cluster binding [GO:0051539]; amidophosphoribosyltransferase activity [GO:0004044]; metal ion binding [GO:0046872]; 'de novo' IMP biosynthetic process [GO:0006189]; cellular response to drug [GO:0035690]; cellular response to insulin stimulus [GO:0032869]; G1/S transition of mitotic cell cycle [GO:0000082]; glutamine catabolic process [GO:0006543]; kidney development [GO:0001822]; lactation [GO:0007595]; maternal process involved in female pregnancy [GO:0060135]; nucleobase-containing small molecule metabolic process [GO:0055086]; nucleoside metabolic process [GO:0009116]; organ regeneration [GO:0031100]; protein homotetramerization [GO:0051289]; purine nucleobase biosynthetic process [GO:0009113]; purine nucleobase metabolic process [GO:0006144]; purine nucleotide biosynthetic process [GO:0006164]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168]; small molecule metabolic process [GO:0044281]	'de novo' IMP biosynthetic process [GO:0006189]; cellular response to drug [GO:0035690]; cellular response to insulin stimulus [GO:0032869]; G1/S transition of mitotic cell cycle [GO:0000082]; glutamine catabolic process [GO:0006543]; kidney development [GO:0001822]; lactation [GO:0007595]; maternal process involved in female pregnancy [GO:0060135]; nucleobase-containing small molecule metabolic process [GO:0055086]; nucleoside metabolic process [GO:0009116]; organ regeneration [GO:0031100]; protein homotetramerization [GO:0051289]; purine nucleobase biosynthetic process [GO:0009113]; purine nucleobase metabolic process [GO:0006144]; purine nucleotide biosynthetic process [GO:0006164]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168]; small molecule metabolic process [GO:0044281]	4 iron, 4 sulfur cluster binding [GO:0051539]; amidophosphoribosyltransferase activity [GO:0004044]; metal ion binding [GO:0046872]	cytosol [GO:0005829]	GO:0006189; GO:0051539; GO:0000082; GO:0004044; GO:0035690; GO:0032869; GO:0005829; GO:0006543; GO:0001822; GO:0007595; GO:0060135; GO:0046872; GO:0055086; GO:0009116; GO:0031100; GO:0051289; GO:0009113; GO:0006144; GO:0006164; GO:0009168; GO:0044281		4Fe-4S; Acetylation; Allosteric enzyme; Complete proteome; Glutamine amidotransferase; Glycosyltransferase; Iron; Iron-sulfur; Magnesium; Metal-binding; Purine biosynthesis; Reference proteome; Transferase	Active site (1); Chain (1); Domain (1); Metal binding (7); Modified residue (1); Propeptide (1); Sequence conflict (1)
ADA_HUMAN	P00813	ADA_HUMAN	reviewed	Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase)	ADA ADA1	Homo sapiens (Human)	363	cell junction [GO:0030054]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic membrane-bounded vesicle lumen [GO:0060205]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; lysosome [GO:0005764]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; adenosine deaminase activity [GO:0004000]; purine nucleoside binding [GO:0001883]; zinc ion binding [GO:0008270]; adenosine catabolic process [GO:0006154]; aging [GO:0007568]; dATP catabolic process [GO:0046061]; deoxyadenosine catabolic process [GO:0006157]; embryonic digestive tract development [GO:0048566]; germinal center B cell differentiation [GO:0002314]; histamine secretion [GO:0001821]; hypoxanthine salvage [GO:0043103]; inosine biosynthetic process [GO:0046103]; liver development [GO:0001889]; lung alveolus development [GO:0048286]; negative regulation of adenosine receptor signaling pathway [GO:0060169]; negative regulation of circadian sleep/wake cycle, non-REM sleep [GO:0042323]; negative regulation of inflammatory response [GO:0050728]; negative regulation of leukocyte migration [GO:0002686]; negative regulation of mature B cell apoptotic process [GO:0002906]; negative regulation of mucus secretion [GO:0070256]; negative regulation of penile erection [GO:0060407]; negative regulation of thymocyte apoptotic process [GO:0070244]; nucleobase-containing small molecule metabolic process [GO:0055086]; Peyer's patch development [GO:0048541]; placenta development [GO:0001890]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of germinal center formation [GO:0002636]; positive regulation of heart rate [GO:0010460]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of T cell differentiation in thymus [GO:0033089]; positive regulation of T cell receptor signaling pathway [GO:0050862]; purine nucleobase metabolic process [GO:0006144]; purine nucleotide salvage [GO:0032261]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168]; purine-containing compound salvage [GO:0043101]; regulation of cell-cell adhesion mediated by integrin [GO:0033632]; response to drug [GO:0042493]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; response to morphine [GO:0043278]; response to vitamin E [GO:0033197]; small molecule metabolic process [GO:0044281]; T cell activation [GO:0042110]; trophectodermal cell differentiation [GO:0001829]; xanthine biosynthetic process [GO:0046111]	adenosine catabolic process [GO:0006154]; aging [GO:0007568]; dATP catabolic process [GO:0046061]; deoxyadenosine catabolic process [GO:0006157]; embryonic digestive tract development [GO:0048566]; germinal center B cell differentiation [GO:0002314]; histamine secretion [GO:0001821]; hypoxanthine salvage [GO:0043103]; inosine biosynthetic process [GO:0046103]; liver development [GO:0001889]; lung alveolus development [GO:0048286]; negative regulation of adenosine receptor signaling pathway [GO:0060169]; negative regulation of circadian sleep/wake cycle, non-REM sleep [GO:0042323]; negative regulation of inflammatory response [GO:0050728]; negative regulation of leukocyte migration [GO:0002686]; negative regulation of mature B cell apoptotic process [GO:0002906]; negative regulation of mucus secretion [GO:0070256]; negative regulation of penile erection [GO:0060407]; negative regulation of thymocyte apoptotic process [GO:0070244]; nucleobase-containing small molecule metabolic process [GO:0055086]; Peyer's patch development [GO:0048541]; placenta development [GO:0001890]; positive regulation of alpha-beta T cell differentiation [GO:0046638]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of germinal center formation [GO:0002636]; positive regulation of heart rate [GO:0010460]; positive regulation of smooth muscle contraction [GO:0045987]; positive regulation of T cell differentiation in thymus [GO:0033089]; positive regulation of T cell receptor signaling pathway [GO:0050862]; purine-containing compound salvage [GO:0043101]; purine nucleobase metabolic process [GO:0006144]; purine nucleotide salvage [GO:0032261]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168]; regulation of cell-cell adhesion mediated by integrin [GO:0033632]; response to drug [GO:0042493]; response to hydrogen peroxide [GO:0042542]; response to hypoxia [GO:0001666]; response to morphine [GO:0043278]; response to vitamin E [GO:0033197]; small molecule metabolic process [GO:0044281]; T cell activation [GO:0042110]; trophectodermal cell differentiation [GO:0001829]; xanthine biosynthetic process [GO:0046111]	adenosine deaminase activity [GO:0004000]; purine nucleoside binding [GO:0001883]; zinc ion binding [GO:0008270]	cell junction [GO:0030054]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic membrane-bounded vesicle lumen [GO:0060205]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; lysosome [GO:0005764]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]	GO:0048541; GO:0042110; GO:0006154; GO:0004000; GO:0007568; GO:0030054; GO:0009986; GO:0005737; GO:0060205; GO:0005829; GO:0046061; GO:0032839; GO:0006157; GO:0048566; GO:0009897; GO:0005615; GO:0002314; GO:0001821; GO:0043103; GO:0046103; GO:0001889; GO:0048286; GO:0005764; GO:0016020; GO:0060169; GO:0042323; GO:0050728; GO:0002686; GO:0002906; GO:0070256; GO:0060407; GO:0070244; GO:0043025; GO:0055086; GO:0001890; GO:0005886; GO:0030890; GO:0033089; GO:0050862; GO:0046638; GO:0050850; GO:0002636; GO:0010460; GO:0045987; GO:0006144; GO:0001883; GO:0032261; GO:0009168; GO:0043101; GO:0033632; GO:0042493; GO:0042542; GO:0001666; GO:0043278; GO:0033197; GO:0044281; GO:0001829; GO:0046111; GO:0008270	SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Extracellular side. Cell junction. Cytoplasmic vesicle lumen {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Colocalized with DPP4 at the cell junction in lymphocyte-epithelial cell adhesion.	3D-structure; Acetylation; Cell adhesion; Cell junction; Cell membrane; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Direct protein sequencing; Disease mutation; Hereditary hemolytic anemia; Hydrolase; Membrane; Metal-binding; Nucleotide metabolism; Polymorphism; Reference proteome; SCID; Zinc	Active site (1); Beta strand (11); Binding site (4); Chain (1); Helix (24); Initiator methionine (1); Metal binding (4); Modified residue (3); Natural variant (33); Sequence conflict (1); Site (1); Turn (2)
PRS7_HUMAN	P35998	PRS7_HUMAN	reviewed	26S protease regulatory subunit 7 (26S proteasome AAA-ATPase subunit RPT1) (Proteasome 26S subunit ATPase 2) (Protein MSS1)	PSMC2 MSS1	Homo sapiens (Human)	433	cytoplasm [GO:0005737]; cytoplasmic mRNA processing body [GO:0000932]; cytosol [GO:0005829]; cytosolic proteasome complex [GO:0031597]; membrane [GO:0016020]; nuclear proteasome complex [GO:0031595]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; proteasome-activating ATPase activity [GO:0036402]; TBP-class protein binding [GO:0017025]; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; osteoblast differentiation [GO:0001649]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [GO:0045899]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; ubiquitin-dependent protein catabolic process [GO:0006511]; viral process [GO:0016032]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; osteoblast differentiation [GO:0001649]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [GO:0045899]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; ubiquitin-dependent protein catabolic process [GO:0006511]; viral process [GO:0016032]	ATPase activity [GO:0016887]; ATP binding [GO:0005524]; proteasome-activating ATPase activity [GO:0036402]; TBP-class protein binding [GO:0017025]	cytoplasm [GO:0005737]; cytoplasmic mRNA processing body [GO:0000932]; cytosol [GO:0005829]; cytosolic proteasome complex [GO:0031597]; membrane [GO:0016020]; nuclear proteasome complex [GO:0031595]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]	GO:0005524; GO:0016887; GO:0006977; GO:0030433; GO:0000082; GO:0017025; GO:0031145; GO:0042590; GO:0002479; GO:0002474; GO:0006915; GO:0034641; GO:0005737; GO:0000932; GO:0005829; GO:0031597; GO:0010467; GO:0045087; GO:0016020; GO:0000278; GO:0043066; GO:0090090; GO:0051436; GO:0031595; GO:0005654; GO:0005634; GO:0001649; GO:0045899; GO:0090263; GO:1901800; GO:0051437; GO:0012501; GO:0022624; GO:0000502; GO:0008540; GO:0036402; GO:0000209; GO:0042981; GO:0006521; GO:0051439; GO:0044281; GO:0002223; GO:0006511; GO:0016032	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, P-body {ECO:0000250}. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250}.	ATP-binding; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Host-virus interaction; Nucleotide-binding; Nucleus; Proteasome; Reference proteome	Alternative sequence (1); Chain (1); Initiator methionine (1); Modified residue (2); Nucleotide binding (1); Sequence conflict (1)
X1WI28_HUMAN	X1WI28	X1WI28_HUMAN	unreviewed	60S ribosomal protein L10 (Fragment)	RPL10	Homo sapiens (Human)	201	ribosome [GO:0005840]; structural constituent of ribosome [GO:0003735]; translation [GO:0006412]	translation [GO:0006412]	structural constituent of ribosome [GO:0003735]	ribosome [GO:0005840]	GO:0005840; GO:0003735; GO:0006412		Complete proteome; Proteomics identification; Reference proteome	Non-terminal residue (1)
RL10_HUMAN	P27635	RL10_HUMAN	reviewed	60S ribosomal protein L10 (Laminin receptor homolog) (Protein QM) (Tumor suppressor QM)	RPL10 DXS648E QM	Homo sapiens (Human)	214	cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; poly(A) RNA binding [GO:0044822]; structural constituent of ribosome [GO:0003735]; cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	poly(A) RNA binding [GO:0044822]; structural constituent of ribosome [GO:0003735]	cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]	GO:0006614; GO:0044267; GO:0005829; GO:0022625; GO:0005783; GO:0010467; GO:0016020; GO:0000184; GO:0044822; GO:0003735; GO:0006412; GO:0006414; GO:0006413; GO:0006415; GO:0019058; GO:0016032; GO:0019083		3D-structure; Autism; Autism spectrum disorder; Citrullination; Complete proteome; Direct protein sequencing; Disease mutation; Isopeptide bond; Polymorphism; Reference proteome; Ribonucleoprotein; Ribosomal protein; Ubl conjugation	Beta strand (7); Chain (1); Cross-link (1); Erroneous gene model prediction (2); Frameshift (1); Helix (4); Initiator methionine (1); Modified residue (1); Natural variant (3); Sequence conflict (2); Turn (1)
STK39_HUMAN	Q9UEW8	STK39_HUMAN	reviewed	STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20-related kinase) (EC 2.7.11.1) (DCHT) (Serine/threonine-protein kinase 39)	STK39 SPAK	Homo sapiens (Human)	545	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]; ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; receptor signaling protein serine/threonine kinase activity [GO:0004702]; activation of protein kinase activity [GO:0032147]; cellular hypotonic response [GO:0071476]; intracellular signal transduction [GO:0035556]; negative regulation of potassium ion transmembrane transport [GO:1901380]; negative regulation of potassium ion transmembrane transporter activity [GO:1901017]; negative regulation of rubidium ion transmembrane transporter activity [GO:2000687]; negative regulation of rubidium ion transport [GO:2000681]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of potassium ion transport [GO:0043268]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981]; regulation of inflammatory response [GO:0050727]; regulation of mitotic cell cycle [GO:0007346]; response to stress [GO:0006950]; signal transduction by protein phosphorylation [GO:0023014]; stress-activated protein kinase signaling cascade [GO:0031098]	activation of protein kinase activity [GO:0032147]; cellular hypotonic response [GO:0071476]; intracellular signal transduction [GO:0035556]; negative regulation of potassium ion transmembrane transport [GO:1901380]; negative regulation of potassium ion transmembrane transporter activity [GO:1901017]; negative regulation of rubidium ion transmembrane transporter activity [GO:2000687]; negative regulation of rubidium ion transport [GO:2000681]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of potassium ion transport [GO:0043268]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981]; regulation of inflammatory response [GO:0050727]; regulation of mitotic cell cycle [GO:0007346]; response to stress [GO:0006950]; signal transduction by protein phosphorylation [GO:0023014]; stress-activated protein kinase signaling cascade [GO:0031098]	ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; receptor signaling protein serine/threonine kinase activity [GO:0004702]	apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]	GO:0005524; GO:0032147; GO:0016324; GO:0016323; GO:0071476; GO:0005737; GO:0005856; GO:0035556; GO:1901380; GO:1901017; GO:2000687; GO:2000681; GO:0005634; GO:0018105; GO:0018107; GO:0043268; GO:0006468; GO:0004674; GO:0004702; GO:0042981; GO:0050727; GO:0007346; GO:0006950; GO:0023014; GO:0031098	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}. Note=Nucleus when caspase-cleaved. {ECO:0000305}.	ATP-binding; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase	Active site (1); Alternative sequence (1); Binding site (1); Chain (1); Compositional bias (1); Domain (1); Modified residue (6); Motif (2); Nucleotide binding (1); Sequence conflict (4)
E5RFF9_HUMAN	E5RFF9	E5RFF9_HUMAN	unreviewed	DNA replication complex GINS protein SLD5	GINS4	Homo sapiens (Human)	192	GINS complex [GO:0000811]; replication fork protection complex [GO:0031298]; DNA duplex unwinding [GO:0032508]; DNA replication initiation [GO:0006270]; double-strand break repair via break-induced replication [GO:0000727]	DNA duplex unwinding [GO:0032508]; DNA replication initiation [GO:0006270]; double-strand break repair via break-induced replication [GO:0000727]		GINS complex [GO:0000811]; replication fork protection complex [GO:0031298]	GO:0032508; GO:0006270; GO:0000811; GO:0000727; GO:0031298	SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR007764}.	Complete proteome; DNA replication; Nucleus; Proteomics identification; Reference proteome	
PFD3_HUMAN	P61758	PFD3_HUMAN	reviewed	Prefoldin subunit 3 (HIBBJ46) (Von Hippel-Lindau-binding protein 1) (VBP-1) (VHL-binding protein 1)	VBP1 PFDN3	Homo sapiens (Human)	197	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; prefoldin complex [GO:0016272]; 'de novo' posttranslational protein folding [GO:0051084]; cellular protein metabolic process [GO:0044267]; protein folding [GO:0006457]	'de novo' posttranslational protein folding [GO:0051084]; cellular protein metabolic process [GO:0044267]; protein folding [GO:0006457]		cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; prefoldin complex [GO:0016272]	GO:0051084; GO:0044267; GO:0005737; GO:0043231; GO:0005634; GO:0016272; GO:0006457	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=In complex with VHL can translocate to the nucleus.	Acetylation; Chaperone; Complete proteome; Cytoplasm; Nucleus; Polymorphism; Reference proteome	Chain (1); Erroneous initiation (1); Initiator methionine (1); Modified residue (2); Natural variant (1)
J3QRS3_HUMAN	J3QRS3	J3QRS3_HUMAN	unreviewed	Myosin regulatory light chain 12A (Myosin regulatory light chain MRCL3, isoform CRA_b)	MYL12A MRCL3 hCG_2045956	Homo sapiens (Human)	177	calcium ion binding [GO:0005509]		calcium ion binding [GO:0005509]		GO:0005509		Calcium; Complete proteome; Proteomics identification; Reference proteome	
METK2_HUMAN	P31153	METK2_HUMAN	reviewed	S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) (Methionine adenosyltransferase II) (MAT-II)	MAT2A AMS2 MATA2	Homo sapiens (Human)	395	cytosol [GO:0005829]; methionine adenosyltransferase complex [GO:0048269]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; methionine adenosyltransferase activity [GO:0004478]; methylation [GO:0032259]; one-carbon metabolic process [GO:0006730]; S-adenosylmethionine biosynthetic process [GO:0006556]; small molecule metabolic process [GO:0044281]; xenobiotic metabolic process [GO:0006805]	methylation [GO:0032259]; one-carbon metabolic process [GO:0006730]; S-adenosylmethionine biosynthetic process [GO:0006556]; small molecule metabolic process [GO:0044281]; xenobiotic metabolic process [GO:0006805]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; methionine adenosyltransferase activity [GO:0004478]	cytosol [GO:0005829]; methionine adenosyltransferase complex [GO:0048269]	GO:0005524; GO:0006556; GO:0005829; GO:0046872; GO:0004478; GO:0048269; GO:0032259; GO:0006730; GO:0044281; GO:0006805		3D-structure; ATP-binding; Acetylation; Alternative splicing; Cobalt; Complete proteome; Magnesium; Metal-binding; Nucleotide-binding; One-carbon metabolism; Phosphoprotein; Potassium; Reference proteome; Transferase	Alternative sequence (2); Beta strand (15); Binding site (1); Chain (1); Helix (15); Metal binding (4); Modified residue (2); Nucleotide binding (1); Turn (4)
RBM7_HUMAN	Q9Y580	RBM7_HUMAN	reviewed	RNA-binding protein 7 (RNA-binding motif protein 7)	RBM7	Homo sapiens (Human)	266	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; meiotic cell cycle [GO:0051321]	meiotic cell cycle [GO:0051321]	nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0051321; GO:0005654; GO:0000166; GO:0005634; GO:0044822		3D-structure; Complete proteome; Meiosis; Phosphoprotein; RNA-binding; Reference proteome	Beta strand (6); Chain (1); Domain (1); Helix (2); Modified residue (1); Sequence conflict (2)
VP13C_HUMAN	Q709C8	VP13C_HUMAN	reviewed	Vacuolar protein sorting-associated protein 13C	VPS13C KIAA1421	Homo sapiens (Human)	3753	cell [GO:0005623]; extracellular exosome [GO:0070062]; extrinsic component of membrane [GO:0019898]; intracellular [GO:0005622]; protein retention in Golgi apparatus [GO:0045053]; protein targeting to vacuole [GO:0006623]	protein retention in Golgi apparatus [GO:0045053]; protein targeting to vacuole [GO:0006623]		cell [GO:0005623]; extracellular exosome [GO:0070062]; extrinsic component of membrane [GO:0019898]; intracellular [GO:0005622]	GO:0005623; GO:0070062; GO:0019898; GO:0005622; GO:0045053; GO:0006623		Acetylation; Alternative splicing; Complete proteome; Isopeptide bond; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation	Alternative sequence (3); Chain (1); Compositional bias (1); Cross-link (1); Erroneous initiation (2); Modified residue (7); Natural variant (10)
EI2BE_HUMAN	Q13144	EI2BE_HUMAN	reviewed	Translation initiation factor eIF-2B subunit epsilon (eIF-2B GDP-GTP exchange factor subunit epsilon)	EIF2B5 EIF2BE	Homo sapiens (Human)	721	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2B complex [GO:0005851]; nucleus [GO:0005634]; guanyl-nucleotide exchange factor activity [GO:0005085]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369]; astrocyte development [GO:0014002]; astrocyte differentiation [GO:0048708]; cellular protein metabolic process [GO:0044267]; cellular response to drug [GO:0035690]; gene expression [GO:0010467]; myelination [GO:0042552]; negative regulation of translational initiation in response to stress [GO:0032057]; oligodendrocyte development [GO:0014003]; ovarian follicle development [GO:0001541]; positive regulation of GTPase activity [GO:0043547]; positive regulation of translational initiation [GO:0045948]; response to endoplasmic reticulum stress [GO:0034976]; response to glucose [GO:0009749]; response to heat [GO:0009408]; response to peptide hormone [GO:0043434]; translation [GO:0006412]; translational initiation [GO:0006413]	astrocyte development [GO:0014002]; astrocyte differentiation [GO:0048708]; cellular protein metabolic process [GO:0044267]; cellular response to drug [GO:0035690]; gene expression [GO:0010467]; myelination [GO:0042552]; negative regulation of translational initiation in response to stress [GO:0032057]; oligodendrocyte development [GO:0014003]; ovarian follicle development [GO:0001541]; positive regulation of GTPase activity [GO:0043547]; positive regulation of translational initiation [GO:0045948]; response to endoplasmic reticulum stress [GO:0034976]; response to glucose [GO:0009749]; response to heat [GO:0009408]; response to peptide hormone [GO:0043434]; translation [GO:0006412]; translational initiation [GO:0006413]	guanyl-nucleotide exchange factor activity [GO:0005085]; translation initiation factor activity [GO:0003743]; translation initiation factor binding [GO:0031369]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2B complex [GO:0005851]; nucleus [GO:0005634]	GO:0014002; GO:0048708; GO:0044267; GO:0035690; GO:0005737; GO:0005829; GO:0005851; GO:0010467; GO:0005085; GO:0042552; GO:0032057; GO:0005634; GO:0014003; GO:0001541; GO:0043547; GO:0045948; GO:0034976; GO:0009749; GO:0009408; GO:0043434; GO:0006412; GO:0003743; GO:0031369; GO:0006413		3D-structure; Acetylation; Complete proteome; Disease mutation; Initiation factor; Isopeptide bond; Leukodystrophy; Phosphoprotein; Polymorphism; Protein biosynthesis; Reference proteome; Ubl conjugation	Chain (1); Compositional bias (1); Cross-link (4); Domain (1); Helix (11); Initiator methionine (1); Modified residue (10); Natural variant (31)
NSUN2_HUMAN	Q08J23	NSUN2_HUMAN	reviewed	tRNA (cytosine(34)-C(5))-methyltransferase (EC 2.1.1.203) (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) (Substrate of AIM1/Aurora kinase B) (tRNA (cytosine-5-)-methyltransferase) (tRNA methyltransferase 4 homolog) (hTrm4)	NSUN2 SAKI TRM4	Homo sapiens (Human)	767	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634]; spindle [GO:0005819]; poly(A) RNA binding [GO:0044822]; tRNA (cytosine-5-)-methyltransferase activity [GO:0016428]; tRNA binding [GO:0000049]; cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; tRNA methylation [GO:0030488]	cell division [GO:0051301]; mitotic nuclear division [GO:0007067]; tRNA methylation [GO:0030488]	poly(A) RNA binding [GO:0044822]; tRNA (cytosine-5-)-methyltransferase activity [GO:0016428]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634]; spindle [GO:0005819]	GO:0051301; GO:0005737; GO:0007067; GO:0005730; GO:0005634; GO:0044822; GO:0005819; GO:0016428; GO:0000049; GO:0030488	SUBCELLULAR LOCATION: Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Note=Concentrated in the nucleolus during interphase and translocates to the spindle during mitosis as an RNA-protein complex that includes 18S ribosomal RNA.	Acetylation; Alternative splicing; Cell cycle; Cell division; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Disease mutation; Mental retardation; Methyltransferase; Mitosis; Nucleus; Phosphoprotein; Polymorphism; RNA-binding; Reference proteome; S-adenosyl-L-methionine; Transferase; tRNA processing; tRNA-binding	Active site (1); Alternative sequence (2); Binding site (3); Chain (1); Erroneous initiation (2); Modified residue (9); Mutagenesis (2); Natural variant (2); Region (1); Sequence conflict (5)
FYB_HUMAN	O15117	FYB_HUMAN	reviewed	FYN-binding protein (Adhesion and degranulation promoting adaptor protein) (ADAP) (FYB-120/130) (p120/p130) (FYN-T-binding protein) (SLAP-130) (SLP-76-associated phosphoprotein)	FYB SLAP130	Homo sapiens (Human)	783	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; nucleus [GO:0005634]; receptor binding [GO:0005102]; immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; NLS-bearing protein import into nucleus [GO:0006607]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]; T cell receptor signaling pathway [GO:0050852]	immune response [GO:0006955]; intracellular signal transduction [GO:0035556]; NLS-bearing protein import into nucleus [GO:0006607]; protein phosphorylation [GO:0006468]; signal transduction [GO:0007165]; T cell receptor signaling pathway [GO:0050852]	receptor binding [GO:0005102]	actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0006607; GO:0050852; GO:0015629; GO:0005829; GO:0006955; GO:0035556; GO:0005634; GO:0006468; GO:0005102; GO:0007165	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9671755}. Nucleus {ECO:0000250}.	3D-structure; Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; SH3 domain	Alternative sequence (2); Beta strand (9); Chain (1); Coiled coil (1); Compositional bias (3); Domain (1); Helix (5); Initiator methionine (1); Modified residue (8); Motif (5); Natural variant (3); Region (1); Sequence conflict (6); Turn (1)
KTHY_HUMAN	P23919	KTHY_HUMAN	reviewed	Thymidylate kinase (EC 2.7.4.9) (dTMP kinase)	DTYMK CDC8 TMPK TYMK	Homo sapiens (Human)	212	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; ATP binding [GO:0005524]; nucleoside phosphate kinase activity [GO:0050145]; thymidylate kinase activity [GO:0004798]; uridylate kinase activity [GO:0009041]; cell cycle [GO:0007049]; cell proliferation [GO:0008283]; cellular response to growth factor stimulus [GO:0071363]; dTDP biosynthetic process [GO:0006233]; dTTP biosynthetic process [GO:0006235]; dUDP biosynthetic process [GO:0006227]; myoblast differentiation [GO:0045445]; nucleobase-containing small molecule interconversion [GO:0015949]; nucleobase-containing small molecule metabolic process [GO:0055086]; nucleoside monophosphate phosphorylation [GO:0046940]; nucleotide phosphorylation [GO:0046939]; response to cadmium ion [GO:0046686]; response to estrogen [GO:0043627]; small molecule metabolic process [GO:0044281]	cell cycle [GO:0007049]; cell proliferation [GO:0008283]; cellular response to growth factor stimulus [GO:0071363]; dTDP biosynthetic process [GO:0006233]; dTTP biosynthetic process [GO:0006235]; dUDP biosynthetic process [GO:0006227]; myoblast differentiation [GO:0045445]; nucleobase-containing small molecule interconversion [GO:0015949]; nucleobase-containing small molecule metabolic process [GO:0055086]; nucleoside monophosphate phosphorylation [GO:0046940]; nucleotide phosphorylation [GO:0046939]; response to cadmium ion [GO:0046686]; response to estrogen [GO:0043627]; small molecule metabolic process [GO:0044281]	ATP binding [GO:0005524]; nucleoside phosphate kinase activity [GO:0050145]; thymidylate kinase activity [GO:0004798]; uridylate kinase activity [GO:0009041]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]	GO:0005524; GO:0007049; GO:0008283; GO:0071363; GO:0005737; GO:0005829; GO:0006233; GO:0006235; GO:0006227; GO:0005758; GO:0005759; GO:0045445; GO:0015949; GO:0055086; GO:0046940; GO:0050145; GO:0046939; GO:0046686; GO:0043627; GO:0044281; GO:0004798; GO:0009041		3D-structure; ATP-binding; Acetylation; Alternative splicing; Complete proteome; Kinase; Nucleotide biosynthesis; Nucleotide-binding; Reference proteome; Transferase	Alternative sequence (1); Beta strand (7); Chain (1); Helix (12); Initiator methionine (1); Modified residue (2); Nucleotide binding (1); Sequence conflict (7)
PRS6A_HUMAN	P17980	PRS6A_HUMAN	reviewed	26S protease regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1)	PSMC3 TBP1	Homo sapiens (Human)	439	cytoplasmic mRNA processing body [GO:0000932]; cytosol [GO:0005829]; cytosolic proteasome complex [GO:0031597]; membrane [GO:0016020]; nuclear proteasome complex [GO:0031595]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; proteasome-activating ATPase activity [GO:0036402]; TBP-class protein binding [GO:0017025]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; blastocyst development [GO:0001824]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of nucleic acid-templated transcription [GO:1903507]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [GO:0045899]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; blastocyst development [GO:0001824]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of nucleic acid-templated transcription [GO:1903507]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [GO:0045899]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	ATPase activity [GO:0016887]; ATP binding [GO:0005524]; proteasome-activating ATPase activity [GO:0036402]; TBP-class protein binding [GO:0017025]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]	cytoplasmic mRNA processing body [GO:0000932]; cytosol [GO:0005829]; cytosolic proteasome complex [GO:0031597]; membrane [GO:0016020]; nuclear proteasome complex [GO:0031595]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]	GO:0005524; GO:0016887; GO:0006977; GO:0030433; GO:0000082; GO:0017025; GO:0031145; GO:0042590; GO:0002479; GO:0002474; GO:0006915; GO:0001824; GO:0034641; GO:0000932; GO:0005829; GO:0031597; GO:0010467; GO:0045087; GO:0016020; GO:0000278; GO:0043066; GO:0090090; GO:1903507; GO:0051436; GO:0031595; GO:0005654; GO:0005634; GO:0048471; GO:0045899; GO:0090263; GO:1901800; GO:0051437; GO:0012501; GO:0022624; GO:0000502; GO:0008540; GO:0036402; GO:0000209; GO:0042981; GO:0006521; GO:0051439; GO:0044281; GO:0002223; GO:0003713; GO:0003714; GO:0016032	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}. Cytoplasm, P-body {ECO:0000250}. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250}.	ATP-binding; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Host-virus interaction; Nucleotide-binding; Nucleus; Phosphoprotein; Proteasome; Reference proteome; Ubl conjugation	Chain (1); Erroneous initiation (1); Modified residue (2); Mutagenesis (2); Nucleotide binding (1); Sequence conflict (2)
H1X_HUMAN	Q92522	H1X_HUMAN	reviewed	Histone H1x	H1FX	Homo sapiens (Human)	213	nucleolus [GO:0005730]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; poly(A) RNA binding [GO:0044822]; nucleosome assembly [GO:0006334]	nucleosome assembly [GO:0006334]	DNA binding [GO:0003677]; poly(A) RNA binding [GO:0044822]	nucleolus [GO:0005730]; nucleosome [GO:0000786]; nucleus [GO:0005634]	GO:0003677; GO:0005730; GO:0000786; GO:0006334; GO:0005634; GO:0044822	SUBCELLULAR LOCATION: Nucleus. Chromosome.	3D-structure; Acetylation; Chromosome; Citrullination; Complete proteome; DNA-binding; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome	Beta strand (3); Chain (1); Domain (1); Helix (3); Initiator methionine (1); Modified residue (6); Turn (2)
GANAB_HUMAN	Q14697	GANAB_HUMAN	reviewed	Neutral alpha-glucosidase AB (EC 3.2.1.84) (Alpha-glucosidase 2) (Glucosidase II subunit alpha)	GANAB G2AN KIAA0088	Homo sapiens (Human)	944	endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; glucosidase II complex [GO:0017177]; Golgi apparatus [GO:0005794]; melanosome [GO:0042470]; membrane [GO:0016020]; carbohydrate binding [GO:0030246]; glucan 1,3-alpha-glucosidase activity [GO:0033919]; poly(A) RNA binding [GO:0044822]; cellular protein metabolic process [GO:0044267]; post-translational protein modification [GO:0043687]; protein folding [GO:0006457]; protein N-linked glycosylation via asparagine [GO:0018279]	cellular protein metabolic process [GO:0044267]; post-translational protein modification [GO:0043687]; protein folding [GO:0006457]; protein N-linked glycosylation via asparagine [GO:0018279]	carbohydrate binding [GO:0030246]; glucan 1,3-alpha-glucosidase activity [GO:0033919]; poly(A) RNA binding [GO:0044822]	endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; glucosidase II complex [GO:0017177]; Golgi apparatus [GO:0005794]; melanosome [GO:0042470]; membrane [GO:0016020]	GO:0005794; GO:0030246; GO:0044267; GO:0005788; GO:0070062; GO:0033919; GO:0017177; GO:0042470; GO:0016020; GO:0044822; GO:0043687; GO:0018279; GO:0006457	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250}. Golgi apparatus {ECO:0000250}. Melanosome {ECO:0000269|PubMed:10929008, ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.	Alternative splicing; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Glycoprotein; Glycosidase; Golgi apparatus; Hydrolase; Polymorphism; Reference proteome; Signal	Active site (3); Alternative sequence (3); Chain (1); Erroneous translation (1); Glycosylation (1); Mutagenesis (1); Natural variant (3); Sequence conflict (4); Signal peptide (1)
C9J3M0_HUMAN	C9J3M0	C9J3M0_HUMAN	unreviewed	UTP--glucose-1-phosphate uridylyltransferase (Fragment)	UGP2	Homo sapiens (Human)	38							Complete proteome; Proteomics identification; Reference proteome	Non-terminal residue (1)
CPNE1_HUMAN	Q99829	CPNE1_HUMAN	reviewed	Copine-1 (Copine I)	CPNE1 CPN1	Homo sapiens (Human)	537	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; endopeptidase activity [GO:0004175]; NF-kappaB binding [GO:0051059]; phosphatidylserine binding [GO:0001786]; protein homodimerization activity [GO:0042803]; transporter activity [GO:0005215]; cellular response to calcium ion [GO:0071277]; glycerophospholipid biosynthetic process [GO:0046474]; lipid metabolic process [GO:0006629]; negative regulation of DNA binding [GO:0043392]; negative regulation of gene expression [GO:0010629]; negative regulation of NIK/NF-kappaB signaling [GO:1901223]; neuron projection extension [GO:1990138]; phospholipid metabolic process [GO:0006644]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; proteolysis [GO:0006508]; regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122]; small molecule metabolic process [GO:0044281]; vesicle-mediated transport [GO:0016192]	cellular response to calcium ion [GO:0071277]; glycerophospholipid biosynthetic process [GO:0046474]; lipid metabolic process [GO:0006629]; negative regulation of DNA binding [GO:0043392]; negative regulation of gene expression [GO:0010629]; negative regulation of NIK/NF-kappaB signaling [GO:1901223]; neuron projection extension [GO:1990138]; phospholipid metabolic process [GO:0006644]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; proteolysis [GO:0006508]; regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122]; small molecule metabolic process [GO:0044281]; vesicle-mediated transport [GO:0016192]	calcium-dependent phospholipid binding [GO:0005544]; calcium ion binding [GO:0005509]; endopeptidase activity [GO:0004175]; NF-kappaB binding [GO:0051059]; phosphatidylserine binding [GO:0001786]; protein homodimerization activity [GO:0042803]; transporter activity [GO:0005215]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0051059; GO:0005509; GO:0005544; GO:0071277; GO:0005737; GO:0005829; GO:0004175; GO:0070062; GO:0046474; GO:0006629; GO:0016020; GO:0043392; GO:1901223; GO:0010629; GO:1990138; GO:0005634; GO:0001786; GO:0006644; GO:0005886; GO:0045666; GO:0051897; GO:1903265; GO:0042803; GO:0006508; GO:0043122; GO:0044281; GO:0005215; GO:0016192		Acetylation; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome; Repeat	Chain (1); Domain (3); Modified residue (2); Natural variant (3); Sequence conflict (2)
RL15_HUMAN	P61313	RL15_HUMAN	reviewed	60S ribosomal protein L15	RPL15 EC45 TCBAP0781	Homo sapiens (Human)	204	cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; ribosome [GO:0005840]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; ribosome [GO:0005840]	GO:0003723; GO:0006614; GO:0044267; GO:0005829; GO:0022625; GO:0070062; GO:0010467; GO:0000184; GO:0005634; GO:0044822; GO:0005840; GO:0003735; GO:0006412; GO:0006414; GO:0006413; GO:0006415; GO:0019058; GO:0016032; GO:0019083		3D-structure; Alternative splicing; Complete proteome; Diamond-Blackfan anemia; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein	Alternative sequence (1); Chain (1); Frameshift (1); Modified residue (2); Sequence conflict (5)
A8MSH5_HUMAN	A8MSH5	A8MSH5_HUMAN		Deleted.											
C19L1_HUMAN	Q69YN2	C19L1_HUMAN	reviewed	CWF19-like protein 1 (C19L1)	CWF19L1	Homo sapiens (Human)	538	catalytic activity [GO:0003824]		catalytic activity [GO:0003824]		GO:0003824		Alternative splicing; Complete proteome; Neurodegeneration; Polymorphism; Reference proteome	Alternative sequence (3); Chain (1); Erroneous gene model prediction (1); Natural variant (4); Sequence conflict (1)
PUR2_HUMAN	P22102	PUR2_HUMAN	reviewed	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)]	GART PGFT PRGS	Homo sapiens (Human)	1010	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; phosphoribosylamine-glycine ligase activity [GO:0004637]; phosphoribosylformylglycinamidine cyclo-ligase activity [GO:0004641]; phosphoribosylglycinamide formyltransferase activity [GO:0004644]; 'de novo' IMP biosynthetic process [GO:0006189]; brainstem development [GO:0003360]; cerebellum development [GO:0021549]; cerebral cortex development [GO:0021987]; glycine metabolic process [GO:0006544]; nucleobase-containing small molecule metabolic process [GO:0055086]; purine nucleobase biosynthetic process [GO:0009113]; purine nucleobase metabolic process [GO:0006144]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168]; response to inorganic substance [GO:0010035]; response to organic substance [GO:0010033]; small molecule metabolic process [GO:0044281]; tetrahydrofolate biosynthetic process [GO:0046654]	'de novo' IMP biosynthetic process [GO:0006189]; brainstem development [GO:0003360]; cerebellum development [GO:0021549]; cerebral cortex development [GO:0021987]; glycine metabolic process [GO:0006544]; nucleobase-containing small molecule metabolic process [GO:0055086]; purine nucleobase biosynthetic process [GO:0009113]; purine nucleobase metabolic process [GO:0006144]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168]; response to inorganic substance [GO:0010035]; response to organic substance [GO:0010033]; small molecule metabolic process [GO:0044281]; tetrahydrofolate biosynthetic process [GO:0046654]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; phosphoribosylamine-glycine ligase activity [GO:0004637]; phosphoribosylformylglycinamidine cyclo-ligase activity [GO:0004641]; phosphoribosylglycinamide formyltransferase activity [GO:0004644]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0006189; GO:0005524; GO:0003360; GO:0021549; GO:0021987; GO:0005829; GO:0070062; GO:0006544; GO:0046872; GO:0008168; GO:0055086; GO:0004637; GO:0004641; GO:0004644; GO:0009113; GO:0006144; GO:0009168; GO:0010035; GO:0010033; GO:0044281; GO:0046654		3D-structure; ATP-binding; Acetylation; Alternative splicing; Complete proteome; Ligase; Manganese; Metal-binding; Multifunctional enzyme; Nucleotide-binding; Polymorphism; Purine biosynthesis; Reference proteome; Transferase	Active site (1); Alternative sequence (1); Beta strand (41); Binding site (2); Chain (1); Domain (1); Helix (41); Initiator methionine (1); Metal binding (2); Modified residue (2); Natural variant (5); Nucleotide binding (1); Region (6); Site (1); Turn (8)
Q32Q12_HUMAN	Q32Q12	Q32Q12_HUMAN	unreviewed	Nucleoside diphosphate kinase (EC 2.7.4.6)	NME1-NME2 NME2 hCG_2001850	Homo sapiens (Human)	292	cytosol [GO:0005829]; intracellular [GO:0005622]; ATP binding [GO:0005524]; nucleoside diphosphate kinase activity [GO:0004550]; CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; purine nucleotide metabolic process [GO:0006163]; pyrimidine nucleotide metabolic process [GO:0006220]; UTP biosynthetic process [GO:0006228]	CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; purine nucleotide metabolic process [GO:0006163]; pyrimidine nucleotide metabolic process [GO:0006220]; UTP biosynthetic process [GO:0006228]	ATP binding [GO:0005524]; nucleoside diphosphate kinase activity [GO:0004550]	cytosol [GO:0005829]; intracellular [GO:0005622]	GO:0005524; GO:0006241; GO:0006183; GO:0006228; GO:0005829; GO:0005622; GO:0004550; GO:0006163; GO:0006220		ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Proteomics identification; Reference proteome; Transferase	
SPT5H_HUMAN	O00267	SPT5H_HUMAN	reviewed	Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein)	SUPT5H SPT5 SPT5H	Homo sapiens (Human)	1087	DSIF complex [GO:0032044]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; poly(A) RNA binding [GO:0044822]; protein heterodimerization activity [GO:0046982]; 7-methylguanosine mRNA capping [GO:0006370]; cell cycle [GO:0007049]; chromatin remodeling [GO:0006338]; DNA-templated transcription, elongation [GO:0006354]; gene expression [GO:0010467]; negative regulation of DNA-templated transcription, elongation [GO:0032785]; negative regulation of mRNA polyadenylation [GO:1900364]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of macroautophagy [GO:0016239]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of viral transcription [GO:0050434]; response to organic substance [GO:0010033]; single stranded viral RNA replication via double stranded DNA intermediate [GO:0039692]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]; viral process [GO:0016032]	7-methylguanosine mRNA capping [GO:0006370]; cell cycle [GO:0007049]; chromatin remodeling [GO:0006338]; DNA-templated transcription, elongation [GO:0006354]; gene expression [GO:0010467]; negative regulation of DNA-templated transcription, elongation [GO:0032785]; negative regulation of mRNA polyadenylation [GO:1900364]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of macroautophagy [GO:0016239]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of viral transcription [GO:0050434]; response to organic substance [GO:0010033]; single stranded viral RNA replication via double stranded DNA intermediate [GO:0039692]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]; viral process [GO:0016032]	chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; poly(A) RNA binding [GO:0044822]; protein heterodimerization activity [GO:0046982]	DSIF complex [GO:0032044]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0006370; GO:0006354; GO:0032044; GO:0007049; GO:0003682; GO:0006338; GO:0019899; GO:0010467; GO:0032785; GO:1900364; GO:0000122; GO:0005654; GO:0005634; GO:0044822; GO:0032786; GO:0016239; GO:0045944; GO:0050434; GO:0046982; GO:0010033; GO:0039692; GO:0006368; GO:0006366; GO:0016032	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10075709}.	3D-structure; Acetylation; Activator; Alternative splicing; Complete proteome; Direct protein sequencing; Methylation; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation	Alternative sequence (1); Beta strand (19); Chain (1); Compositional bias (2); Domain (5); Erroneous initiation (1); Helix (5); Modified residue (12); Mutagenesis (7); Region (4); Repeat (19); Sequence conflict (4); Turn (5)
DCTP1_HUMAN	Q9H773	DCTP1_HUMAN	reviewed	dCTP pyrophosphatase 1 (EC 3.6.1.12) (Deoxycytidine-triphosphatase 1) (dCTPase 1) (RS21C6) (XTP3-transactivated gene A protein)	DCTPP1 XTP3TPA CDA03	Homo sapiens (Human)	170	cytosol [GO:0005829]; dCTP diphosphatase activity [GO:0047840]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; nucleoside-triphosphate diphosphatase activity [GO:0047429]; pyrimidine deoxyribonucleotide binding [GO:0032556]; nucleoside triphosphate catabolic process [GO:0009143]; protein homotetramerization [GO:0051289]	nucleoside triphosphate catabolic process [GO:0009143]; protein homotetramerization [GO:0051289]	dCTP diphosphatase activity [GO:0047840]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; nucleoside-triphosphate diphosphatase activity [GO:0047429]; pyrimidine deoxyribonucleotide binding [GO:0032556]	cytosol [GO:0005829]	GO:0005829; GO:0047840; GO:0042802; GO:0000287; GO:0009143; GO:0047429; GO:0051289; GO:0032556	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.	Acetylation; Complete proteome; Cytoplasm; Hydrolase; Magnesium; Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome	Binding site (3); Chain (1); Initiator methionine (1); Metal binding (4); Modified residue (4); Region (1); Repeat (1)
PRP16_HUMAN	Q92620	PRP16_HUMAN	reviewed	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (EC 3.6.4.13) (ATP-dependent RNA helicase DHX38) (DEAH box protein 38)	DHX38 DDX38 KIAA0224 PRP16	Homo sapiens (Human)	1227	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP-dependent RNA helicase activity [GO:0004004]; poly(A) RNA binding [GO:0044822]; gene expression [GO:0010467]; mRNA 3'-end processing [GO:0031124]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; termination of RNA polymerase II transcription [GO:0006369]; transcription from RNA polymerase II promoter [GO:0006366]	gene expression [GO:0010467]; mRNA 3'-end processing [GO:0031124]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; termination of RNA polymerase II transcription [GO:0006369]; transcription from RNA polymerase II promoter [GO:0006366]	ATP binding [GO:0005524]; ATP-dependent RNA helicase activity [GO:0004004]; poly(A) RNA binding [GO:0044822]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005524; GO:0004004; GO:0008380; GO:0071013; GO:0005737; GO:0010467; GO:0031124; GO:0006406; GO:0000398; GO:0016020; GO:0005654; GO:0005634; GO:0044822; GO:0006369; GO:0006366	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.	ATP-binding; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Helicase; Hydrolase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Spliceosome; mRNA processing; mRNA splicing	Alternative sequence (1); Chain (1); Domain (2); Erroneous initiation (1); Initiator methionine (1); Modified residue (4); Motif (1); Natural variant (1); Nucleotide binding (1)
B1AVU8_HUMAN	B1AVU8	B1AVU8_HUMAN		Deleted.											
KPTN_HUMAN	Q9Y664	KPTN_HUMAN	reviewed	Kaptin (Actin-associated protein 2E4)	KPTN	Homo sapiens (Human)	436	actin cytoskeleton [GO:0015629]; growth cone [GO:0030426]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; stereocilium [GO:0032420]; actin binding [GO:0003779]; actin filament organization [GO:0007015]; movement of cell or subcellular component [GO:0006928]; sensory perception of sound [GO:0007605]	actin filament organization [GO:0007015]; movement of cell or subcellular component [GO:0006928]; sensory perception of sound [GO:0007605]	actin binding [GO:0003779]	actin cytoskeleton [GO:0015629]; growth cone [GO:0030426]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; stereocilium [GO:0032420]	GO:0003779; GO:0015629; GO:0007015; GO:0030426; GO:0005815; GO:0006928; GO:0005634; GO:0048471; GO:0007605; GO:0032420	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, perinuclear region. Cell projection, stereocilium. Cell projection, growth cone. Note=Perinuclear at the tips of stereocilium in the inner ear. Localized at sites of actin polymerization in motile fibroblasts and neuronal growth cones.	Acetylation; Actin-binding; Alternative splicing; Cell projection; Complete proteome; Cytoplasm; Disease mutation; Mental retardation; Reference proteome	Alternative sequence (1); Chain (1); Frameshift (1); Modified residue (1); Natural variant (1); Sequence conflict (8)
ANFY1_HUMAN	Q9P2R3	ANFY1_HUMAN	reviewed	Rabankyrin-5 (Rank-5) (Ankyrin repeat and FYVE domain-containing protein 1) (Ankyrin repeats hooked to a zinc finger motif)	ANKFY1 ANKHZN KIAA1255	Homo sapiens (Human)	1169	early endosome [GO:0005769]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; macropinosome [GO:0044354]; membrane [GO:0016020]; metal ion binding [GO:0046872]; phosphatidylinositol phosphate binding [GO:1901981]; Rab GTPase binding [GO:0017137]; endocytosis [GO:0006897]; endosomal vesicle fusion [GO:0034058]; endosome localization [GO:0032439]; Golgi to lysosome transport [GO:0090160]; positive regulation of pinocytosis [GO:0048549]; retrograde transport, endosome to Golgi [GO:0042147]	endocytosis [GO:0006897]; endosomal vesicle fusion [GO:0034058]; endosome localization [GO:0032439]; Golgi to lysosome transport [GO:0090160]; positive regulation of pinocytosis [GO:0048549]; retrograde transport, endosome to Golgi [GO:0042147]	metal ion binding [GO:0046872]; phosphatidylinositol phosphate binding [GO:1901981]; Rab GTPase binding [GO:0017137]	early endosome [GO:0005769]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; macropinosome [GO:0044354]; membrane [GO:0016020]	GO:0090160; GO:0017137; GO:0005769; GO:0006897; GO:0034058; GO:0032439; GO:0010008; GO:0070062; GO:0005765; GO:0044354; GO:0016020; GO:0046872; GO:1901981; GO:0048549; GO:0042147	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10940552}. Endosome membrane {ECO:0000269|PubMed:10940552}; Peripheral membrane protein {ECO:0000269|PubMed:10940552}. Early endosome {ECO:0000269|PubMed:15328530}. Note=Also associated with endosomal membranes. Localizes to macropinosomes. {ECO:0000269|PubMed:15328530}.	ANK repeat; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Endocytosis; Endosome; Membrane; Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger	Alternative sequence (2); Chain (1); Domain (1); Erroneous initiation (1); Initiator methionine (1); Modified residue (1); Motif (1); Mutagenesis (2); Region (1); Repeat (21); Sequence caution (1); Sequence conflict (35); Zinc finger (1)
GSHR_HUMAN	P00390	GSHR_HUMAN	reviewed	Glutathione reductase, mitochondrial (GR) (GRase) (EC 1.8.1.7)	GSR GLUR GRD1	Homo sapiens (Human)	522	cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; electron carrier activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660]; glutathione-disulfide reductase activity [GO:0004362]; NADP binding [GO:0050661]; cell redox homeostasis [GO:0045454]; gene expression [GO:0010467]; glutathione metabolic process [GO:0006749]; nucleobase-containing small molecule interconversion [GO:0015949]; nucleobase-containing small molecule metabolic process [GO:0055086]; response to reactive oxygen species [GO:0000302]; small molecule metabolic process [GO:0044281]; transcription initiation from RNA polymerase II promoter [GO:0006367]	cell redox homeostasis [GO:0045454]; gene expression [GO:0010467]; glutathione metabolic process [GO:0006749]; nucleobase-containing small molecule interconversion [GO:0015949]; nucleobase-containing small molecule metabolic process [GO:0055086]; response to reactive oxygen species [GO:0000302]; small molecule metabolic process [GO:0044281]; transcription initiation from RNA polymerase II promoter [GO:0006367]	electron carrier activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660]; glutathione-disulfide reductase activity [GO:0004362]; NADP binding [GO:0050661]	cytosol [GO:0005829]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]	GO:0050661; GO:0045454; GO:0005829; GO:0009055; GO:0009897; GO:0070062; GO:0050660; GO:0010467; GO:0006749; GO:0004362; GO:0005759; GO:0015949; GO:0055086; GO:0000302; GO:0044281; GO:0006367	SUBCELLULAR LOCATION: Isoform Mitochondrial: Mitochondrion.; SUBCELLULAR LOCATION: Isoform Cytoplasmic: Cytoplasm.	3D-structure; Acetylation; Alternative initiation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; FAD; Flavoprotein; Mitochondrion; NADP; Oxidoreductase; Polymorphism; Redox-active center; Reference proteome; Transit peptide	Active site (1); Alternative sequence (3); Beta strand (25); Chain (1); Disulfide bond (2); Erroneous initiation (1); Helix (17); Modified residue (1); Natural variant (6); Nucleotide binding (1); Transit peptide (1); Turn (4)
ROA2_HUMAN	P22626	ROA2_HUMAN	reviewed	Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1)	HNRNPA2B1 HNRPA2B1	Homo sapiens (Human)	353	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]; spliceosomal complex [GO:0005681]; nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; pre-mRNA intronic binding [GO:0097157]; RNA binding [GO:0003723]; single-stranded telomeric DNA binding [GO:0043047]; gene expression [GO:0010467]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; RNA splicing [GO:0008380]; RNA transport [GO:0050658]	gene expression [GO:0010467]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; RNA splicing [GO:0008380]; RNA transport [GO:0050658]	nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; pre-mRNA intronic binding [GO:0097157]; RNA binding [GO:0003723]; single-stranded telomeric DNA binding [GO:0043047]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]; spliceosomal complex [GO:0005681]	GO:0003723; GO:0008380; GO:0050658; GO:0071013; GO:0005737; GO:0010467; GO:0006397; GO:0000398; GO:0016020; GO:0048025; GO:0000122; GO:0005654; GO:0000166; GO:0005634; GO:0044822; GO:0097157; GO:0030529; GO:0043047; GO:0005681	SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:17289661}. Cytoplasm {ECO:0000269|PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Predominantly nucleoplasmic, however isoform A2 is also found in the cytoplasm of cells in some tissues. Not found in the nucleolus.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Methylation; Nucleus; Phosphoprotein; RNA-binding; Reference proteome; Repeat; Ribonucleoprotein; Spliceosome; mRNA processing; mRNA splicing	Alternative sequence (1); Beta strand (5); Chain (1); Compositional bias (1); Domain (2); Helix (3); Modified residue (21); Motif (1); Natural variant (1); Region (1); Sequence conflict (1); Turn (1)
RL13_HUMAN	P26373	RL13_HUMAN	reviewed	60S ribosomal protein L13 (Breast basic conserved protein 1)	RPL13 BBC1 OK/SW-cl.46	Homo sapiens (Human)	211	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0003723; GO:0006614; GO:0044267; GO:0005737; GO:0005829; GO:0022625; GO:0022626; GO:0010467; GO:0016020; GO:0000184; GO:0005730; GO:0005634; GO:0044822; GO:0003735; GO:0006412; GO:0006414; GO:0006413; GO:0006415; GO:0019058; GO:0016032; GO:0019083		3D-structure; Acetylation; Alternative splicing; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome; Ribonucleoprotein; Ribosomal protein	Alternative sequence (1); Chain (1); Modified residue (4); Natural variant (2); Sequence conflict (1)
SYMC_HUMAN	P56192	SYMC_HUMAN	reviewed	Methionine--tRNA ligase, cytoplasmic (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS)	MARS	Homo sapiens (Human)	900	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; methionine-tRNA ligase activity [GO:0004825]; tRNA binding [GO:0000049]; gene expression [GO:0010467]; methionyl-tRNA aminoacylation [GO:0006431]; tRNA aminoacylation for protein translation [GO:0006418]	gene expression [GO:0010467]; methionyl-tRNA aminoacylation [GO:0006431]; tRNA aminoacylation for protein translation [GO:0006418]	ATP binding [GO:0005524]; methionine-tRNA ligase activity [GO:0004825]; tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrion [GO:0005739]	GO:0005524; GO:0005737; GO:0005829; GO:0070062; GO:0010467; GO:0016020; GO:0004825; GO:0006431; GO:0005739; GO:0006418; GO:0000049	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.	3D-structure; ATP-binding; Alternative splicing; Aminoacyl-tRNA synthetase; Charcot-Marie-Tooth disease; Complete proteome; Cytoplasm; Disease mutation; Ligase; Neurodegeneration; Neuropathy; Nucleotide-binding; Polymorphism; Protein biosynthesis; RNA-binding; Reference proteome; tRNA-binding	Alternative sequence (2); Beta strand (6); Binding site (1); Chain (1); Domain (2); Helix (16); Motif (2); Natural variant (5); Sequence conflict (7); Turn (1)
E9PMD5_HUMAN	E9PMD5	E9PMD5_HUMAN	unreviewed	Transcription factor p65 (Fragment)	RELA	Homo sapiens (Human)	161	cytoplasm [GO:0005737]; I-kappaB/NF-kappaB complex [GO:0033256]; NF-kappaB complex [GO:0071159]; nucleoplasm [GO:0005654]; sequence-specific DNA binding transcription factor activity [GO:0003700]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; innate immune response [GO:0045087]; NIK/NF-kappaB signaling [GO:0038061]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]	I-kappaB kinase/NF-kappaB signaling [GO:0007249]; innate immune response [GO:0045087]; NIK/NF-kappaB signaling [GO:0038061]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]	sequence-specific DNA binding transcription factor activity [GO:0003700]	cytoplasm [GO:0005737]; I-kappaB/NF-kappaB complex [GO:0033256]; NF-kappaB complex [GO:0071159]; nucleoplasm [GO:0005654]	GO:0007249; GO:0033256; GO:0071159; GO:0038061; GO:0005737; GO:0045087; GO:0005654; GO:0051092; GO:0003700		Complete proteome; Proteomics identification; Reference proteome	Non-terminal residue (1)
ARPC5_HUMAN	O15511	ARPC5_HUMAN	reviewed	Actin-related protein 2/3 complex subunit 5 (Arp2/3 complex 16 kDa subunit) (p16-ARC)	ARPC5 ARC16	Homo sapiens (Human)	151	actin cytoskeleton [GO:0015629]; Arp2/3 protein complex [GO:0005885]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; structural constituent of cytoskeleton [GO:0005200]; actin cytoskeleton organization [GO:0030036]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; axon guidance [GO:0007411]; cell migration [GO:0016477]; ephrin receptor signaling pathway [GO:0048013]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; innate immune response [GO:0045087]; movement of cell or subcellular component [GO:0006928]; small GTPase mediated signal transduction [GO:0007264]	actin cytoskeleton organization [GO:0030036]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; axon guidance [GO:0007411]; cell migration [GO:0016477]; ephrin receptor signaling pathway [GO:0048013]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; innate immune response [GO:0045087]; movement of cell or subcellular component [GO:0006928]; small GTPase mediated signal transduction [GO:0007264]	structural constituent of cytoskeleton [GO:0005200]	actin cytoskeleton [GO:0015629]; Arp2/3 protein complex [GO:0005885]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]	GO:0034314; GO:0005885; GO:0038096; GO:0015629; GO:0030036; GO:0007411; GO:0016477; GO:0042995; GO:0005737; GO:0005829; GO:0048013; GO:0070062; GO:0005925; GO:0045087; GO:0006928; GO:0007264; GO:0005200	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9230079}. Cell projection {ECO:0000269|PubMed:9230079}.	Acetylation; Actin-binding; Alternative splicing; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Reference proteome; Ubl conjugation	Alternative sequence (1); Chain (1); Initiator methionine (1); Modified residue (1)
K1C9_HUMAN	P35527	K1C9_HUMAN	reviewed	Keratin, type I cytoskeletal 9 (Cytokeratin-9) (CK-9) (Keratin-9) (K9)	KRT9	Homo sapiens (Human)	623	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; intermediate filament [GO:0005882]; membrane [GO:0016020]; nucleus [GO:0005634]; structural constituent of cytoskeleton [GO:0005200]; epidermis development [GO:0008544]; intermediate filament organization [GO:0045109]; skin development [GO:0043588]; spermatogenesis [GO:0007283]	epidermis development [GO:0008544]; intermediate filament organization [GO:0045109]; skin development [GO:0043588]; spermatogenesis [GO:0007283]	structural constituent of cytoskeleton [GO:0005200]	extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; intermediate filament [GO:0005882]; membrane [GO:0016020]; nucleus [GO:0005634]	GO:0008544; GO:0070062; GO:0005615; GO:0005882; GO:0045109; GO:0016020; GO:0005634; GO:0043588; GO:0007283; GO:0005200		Coiled coil; Complete proteome; Direct protein sequencing; Disease mutation; Intermediate filament; Keratin; Palmoplantar keratoderma; Phosphoprotein; Reference proteome	Chain (1); Compositional bias (1); Modified residue (1); Mutagenesis (1); Natural variant (22); Region (8); Sequence conflict (9)
FAS_HUMAN	P49327	FAS_HUMAN	reviewed	Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)]	FASN FAS	Homo sapiens (Human)	2511	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glycogen granule [GO:0042587]; Golgi apparatus [GO:0005794]; melanosome [GO:0042470]; membrane [GO:0016020]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity [GO:0047451]; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity [GO:0004317]; 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity [GO:0004316]; 3-oxoacyl-[acyl-carrier-protein] synthase activity [GO:0004315]; [acyl-carrier-protein] S-acetyltransferase activity [GO:0004313]; [acyl-carrier-protein] S-malonyltransferase activity [GO:0004314]; drug binding [GO:0008144]; enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity [GO:0047117]; enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity [GO:0004319]; fatty acid synthase activity [GO:0004312]; myristoyl-[acyl-carrier-protein] hydrolase activity [GO:0016295]; NADPH binding [GO:0070402]; oleoyl-[acyl-carrier-protein] hydrolase activity [GO:0004320]; palmitoyl-[acyl-carrier-protein] hydrolase activity [GO:0016296]; poly(A) RNA binding [GO:0044822]; zinc ion binding [GO:0008270]; acetyl-CoA metabolic process [GO:0006084]; cellular lipid metabolic process [GO:0044255]; cellular response to interleukin-4 [GO:0071353]; energy reserve metabolic process [GO:0006112]; fatty acid biosynthetic process [GO:0006633]; fatty acid metabolic process [GO:0006631]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; osteoblast differentiation [GO:0001649]; pantothenate metabolic process [GO:0015939]; positive regulation of cellular metabolic process [GO:0031325]; small molecule metabolic process [GO:0044281]; triglyceride biosynthetic process [GO:0019432]; vitamin metabolic process [GO:0006766]; water-soluble vitamin metabolic process [GO:0006767]	acetyl-CoA metabolic process [GO:0006084]; cellular lipid metabolic process [GO:0044255]; cellular response to interleukin-4 [GO:0071353]; energy reserve metabolic process [GO:0006112]; fatty acid biosynthetic process [GO:0006633]; fatty acid metabolic process [GO:0006631]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; osteoblast differentiation [GO:0001649]; pantothenate metabolic process [GO:0015939]; positive regulation of cellular metabolic process [GO:0031325]; small molecule metabolic process [GO:0044281]; triglyceride biosynthetic process [GO:0019432]; vitamin metabolic process [GO:0006766]; water-soluble vitamin metabolic process [GO:0006767]	[acyl-carrier-protein] S-acetyltransferase activity [GO:0004313]; [acyl-carrier-protein] S-malonyltransferase activity [GO:0004314]; 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity [GO:0047451]; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity [GO:0004317]; 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity [GO:0004316]; 3-oxoacyl-[acyl-carrier-protein] synthase activity [GO:0004315]; drug binding [GO:0008144]; enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity [GO:0047117]; enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity [GO:0004319]; fatty acid synthase activity [GO:0004312]; myristoyl-[acyl-carrier-protein] hydrolase activity [GO:0016295]; NADPH binding [GO:0070402]; oleoyl-[acyl-carrier-protein] hydrolase activity [GO:0004320]; palmitoyl-[acyl-carrier-protein] hydrolase activity [GO:0016296]; poly(A) RNA binding [GO:0044822]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glycogen granule [GO:0042587]; Golgi apparatus [GO:0005794]; melanosome [GO:0042470]; membrane [GO:0016020]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]	GO:0047451; GO:0004317; GO:0004316; GO:0004315; GO:0005794; GO:0070402; GO:0004313; GO:0004314; GO:0006084; GO:0044255; GO:0071353; GO:0005737; GO:0005829; GO:0008144; GO:0006112; GO:0047117; GO:0004319; GO:0070062; GO:0006633; GO:0006631; GO:0004312; GO:0042587; GO:0035338; GO:0042470; GO:0016020; GO:0005739; GO:0016295; GO:0004320; GO:0001649; GO:0016296; GO:0015939; GO:0005886; GO:0044822; GO:0031325; GO:0044281; GO:0019432; GO:0006766; GO:0006767; GO:0008270	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Fatty acid biosynthesis; Fatty acid metabolism; Hydrolase; Lipid biosynthesis; Lipid metabolism; Lyase; Multifunctional enzyme; NAD; NADP; Oxidoreductase; Phosphopantetheine; Phosphoprotein; Polymorphism; Pyridoxal phosphate; Reference proteome; Transferase	Active site (5); Beta strand (73); Chain (1); Domain (1); Erroneous initiation (2); Helix (102); Modified residue (21); Natural variant (3); Nucleotide binding (2); Region (5); Sequence caution (1); Sequence conflict (20); Turn (18)
PSB6_HUMAN	P28072	PSB6_HUMAN	reviewed	Proteasome subunit beta type-6 (EC 3.4.25.1) (Macropain delta chain) (Multicatalytic endopeptidase complex delta chain) (Proteasome delta chain) (Proteasome subunit Y)	PSMB6 LMPY Y	Homo sapiens (Human)	239	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298]; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]	GO:0006977; GO:0000082; GO:0005794; GO:0031145; GO:0042590; GO:0002479; GO:0002474; GO:0006915; GO:0034641; GO:0005737; GO:0005829; GO:0004175; GO:0070062; GO:0010467; GO:0045087; GO:0000278; GO:0043066; GO:0090090; GO:0051436; GO:0005654; GO:0005634; GO:0090263; GO:0051437; GO:0012501; GO:0010499; GO:0000502; GO:0005839; GO:0043161; GO:0000209; GO:0042981; GO:0006521; GO:0051439; GO:0044281; GO:0002223; GO:0004298; GO:0016032	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Host-virus interaction; Hydrolase; Nucleus; Polymorphism; Protease; Proteasome; Reference proteome; Threonine protease; Zymogen	Active site (1); Beta strand (12); Chain (1); Helix (6); Initiator methionine (1); Modified residue (1); Natural variant (1); Propeptide (1); Sequence conflict (1); Turn (2)
E9PEX6_HUMAN	E9PEX6	E9PEX6_HUMAN	unreviewed	Dihydrolipoyl dehydrogenase (EC 1.8.1.4)	DLD	Homo sapiens (Human)	486	mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; dihydrolipoyl dehydrogenase activity [GO:0004148]; flavin adenine dinucleotide binding [GO:0050660]; cell redox homeostasis [GO:0045454]	cell redox homeostasis [GO:0045454]	dihydrolipoyl dehydrogenase activity [GO:0004148]; flavin adenine dinucleotide binding [GO:0050660]	mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	GO:0045454; GO:0004148; GO:0050660; GO:0005739; GO:0005654		Complete proteome; FAD; Flavoprotein; NAD; Oxidoreductase; Proteomics identification; Redox-active center; Reference proteome	
PUR6_HUMAN	P22234	PUR6_HUMAN	reviewed	Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6) (SAICAR synthetase); Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC)]	PAICS ADE2 AIRC PAIS	Homo sapiens (Human)	425	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; phosphoribosylaminoimidazole carboxylase activity [GO:0004638]; phosphoribosylaminoimidazolesuccinocarboxamide synthase activity [GO:0004639]; 'de novo' IMP biosynthetic process [GO:0006189]; nucleobase-containing small molecule metabolic process [GO:0055086]; purine nucleobase biosynthetic process [GO:0009113]; purine nucleobase metabolic process [GO:0006144]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168]; small molecule metabolic process [GO:0044281]	'de novo' IMP biosynthetic process [GO:0006189]; nucleobase-containing small molecule metabolic process [GO:0055086]; purine nucleobase biosynthetic process [GO:0009113]; purine nucleobase metabolic process [GO:0006144]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168]; small molecule metabolic process [GO:0044281]	ATP binding [GO:0005524]; identical protein binding [GO:0042802]; phosphoribosylaminoimidazole carboxylase activity [GO:0004638]; phosphoribosylaminoimidazolesuccinocarboxamide synthase activity [GO:0004639]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]	GO:0006189; GO:0005524; GO:0005829; GO:0070062; GO:0042802; GO:0016020; GO:0055086; GO:0004638; GO:0004639; GO:0009113; GO:0006144; GO:0009168; GO:0044281		3D-structure; ATP-binding; Acetylation; Alternative splicing; Complete proteome; Decarboxylase; Direct protein sequencing; Ligase; Lyase; Multifunctional enzyme; Nucleotide-binding; Phosphoprotein; Polymorphism; Purine biosynthesis; Reference proteome	Active site (5); Alternative sequence (1); Beta strand (15); Chain (1); Helix (15); Initiator methionine (1); Modified residue (8); Mutagenesis (4); Natural variant (1); Region (3); Sequence conflict (2); Site (1); Turn (4)
IF2B_HUMAN	P20042	IF2B_HUMAN	reviewed	Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF-2-beta)	EIF2S2 EIF2B	Homo sapiens (Human)	333	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2 complex [GO:0005850]; metal ion binding [GO:0046872]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]; cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; in utero embryonic development [GO:0001701]; male germ cell proliferation [GO:0002176]; male gonad development [GO:0008584]; translation [GO:0006412]; translational initiation [GO:0006413]; transmembrane transport [GO:0055085]	cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; in utero embryonic development [GO:0001701]; male germ cell proliferation [GO:0002176]; male gonad development [GO:0008584]; translation [GO:0006412]; translational initiation [GO:0006413]; transmembrane transport [GO:0055085]	metal ion binding [GO:0046872]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2 complex [GO:0005850]	GO:0003723; GO:0044267; GO:0005737; GO:0005829; GO:0005850; GO:0010467; GO:0001701; GO:0002176; GO:0008584; GO:0046872; GO:0044822; GO:0006412; GO:0008135; GO:0003743; GO:0006413; GO:0055085		Acetylation; Complete proteome; Initiation factor; Metal-binding; Phosphoprotein; Polymorphism; Protein biosynthesis; Reference proteome; Zinc; Zinc-finger	Chain (1); Compositional bias (3); Initiator methionine (1); Modified residue (10); Natural variant (1); Sequence conflict (1); Zinc finger (1)
RHG05_HUMAN	Q13017	RHG05_HUMAN	reviewed	Rho GTPase-activating protein 5 (Rho-type GTPase-activating protein 5) (p190-B)	ARHGAP5 RHOGAP5	Homo sapiens (Human)	1502	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; SH2 domain binding [GO:0042169]; cell adhesion [GO:0007155]; mammary gland development [GO:0030879]; metabolic process [GO:0008152]; positive regulation of cell migration [GO:0030335]; positive regulation of GTPase activity [GO:0043547]; positive regulation of mesenchymal cell proliferation [GO:0002053]; regulation of cell size [GO:0008361]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]; small GTPase mediated signal transduction [GO:0007264]	cell adhesion [GO:0007155]; mammary gland development [GO:0030879]; metabolic process [GO:0008152]; positive regulation of cell migration [GO:0030335]; positive regulation of GTPase activity [GO:0043547]; positive regulation of mesenchymal cell proliferation [GO:0002053]; regulation of cell size [GO:0008361]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]; small GTPase mediated signal transduction [GO:0007264]	GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; GTP binding [GO:0005525]; SH2 domain binding [GO:0042169]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]	GO:0005525; GO:0005096; GO:0003924; GO:0007266; GO:0042169; GO:0007155; GO:0005737; GO:0005829; GO:0030879; GO:0016020; GO:0008152; GO:0043547; GO:0030335; GO:0002053; GO:0008361; GO:0051056; GO:0007264	SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Note=Also membrane-associated when found in fibrillar patterns that colocalize with the alpha5-beta1 integrin receptor (ITGA5/ITGB1) for fibronectin.	3D-structure; Alternative splicing; Complete proteome; Cytoplasm; GTPase activation; Membrane; Nitration; Phosphoprotein; Polymorphism; Reference proteome; Repeat	Alternative sequence (4); Beta strand (3); Chain (1); Compositional bias (1); Domain (5); Frameshift (1); Helix (12); Modified residue (10); Natural variant (1); Sequence caution (1); Sequence conflict (5); Turn (3)
H3BMX9_HUMAN	H3BMX9	H3BMX9_HUMAN	unreviewed	Protein FAM192A (Fragment)	FAM192A	Homo sapiens (Human)	165							Complete proteome; Proteomics identification; Reference proteome	Non-terminal residue (1)
PRDX2_HUMAN	P32119	PRDX2_HUMAN	reviewed	Peroxiredoxin-2 (EC 1.11.1.15) (Natural killer cell-enhancing factor B) (NKEF-B) (PRP) (Thiol-specific antioxidant protein) (TSA) (Thioredoxin peroxidase 1) (Thioredoxin-dependent peroxide reductase 1)	PRDX2 NKEFB TDPX1	Homo sapiens (Human)	198	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; antioxidant activity [GO:0016209]; thioredoxin peroxidase activity [GO:0008379]; cellular response to oxidative stress [GO:0034599]; gene expression [GO:0010467]; hydrogen peroxide catabolic process [GO:0042744]; negative regulation of apoptotic process [GO:0043066]; negative regulation of neuron apoptotic process [GO:0043524]; regulation of apoptotic process [GO:0042981]; removal of superoxide radicals [GO:0019430]; response to oxidative stress [GO:0006979]; response to reactive oxygen species [GO:0000302]; transcription initiation from RNA polymerase II promoter [GO:0006367]	cellular response to oxidative stress [GO:0034599]; gene expression [GO:0010467]; hydrogen peroxide catabolic process [GO:0042744]; negative regulation of apoptotic process [GO:0043066]; negative regulation of neuron apoptotic process [GO:0043524]; regulation of apoptotic process [GO:0042981]; removal of superoxide radicals [GO:0019430]; response to oxidative stress [GO:0006979]; response to reactive oxygen species [GO:0000302]; transcription initiation from RNA polymerase II promoter [GO:0006367]	antioxidant activity [GO:0016209]; thioredoxin peroxidase activity [GO:0008379]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0016209; GO:0034599; GO:0005737; GO:0005829; GO:0070062; GO:0010467; GO:0042744; GO:0043066; GO:0043524; GO:0042981; GO:0019430; GO:0006979; GO:0000302; GO:0008379; GO:0006367	SUBCELLULAR LOCATION: Cytoplasm.	3D-structure; Acetylation; Alternative splicing; Antioxidant; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; Oxidoreductase; Peroxidase; Phosphoprotein; Polymorphism; Redox-active center; Reference proteome	Active site (1); Alternative sequence (1); Beta strand (7); Chain (1); Disulfide bond (2); Domain (1); Helix (8); Initiator methionine (1); Modified residue (3); Natural variant (1); Sequence conflict (7); Turn (2)
DNJC9_HUMAN	Q8WXX5	DNJC9_HUMAN	reviewed	DnaJ homolog subfamily C member 9 (DnaJ protein SB73)	DNAJC9	Homo sapiens (Human)	260	nucleus [GO:0005634]; social behavior [GO:0035176]	social behavior [GO:0035176]		nucleus [GO:0005634]	GO:0005634; GO:0035176		Chaperone; Complete proteome; Phosphoprotein; Reference proteome	Chain (1); Domain (1); Modified residue (1)
GSH1_HUMAN	P48506	GSH1_HUMAN	reviewed	Glutamate--cysteine ligase catalytic subunit (EC 6.3.2.2) (GCS heavy chain) (Gamma-ECS) (Gamma-glutamylcysteine synthetase)	GCLC GLCL GLCLC	Homo sapiens (Human)	637	cytosol [GO:0005829]; glutamate-cysteine ligase complex [GO:0017109]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; coenzyme binding [GO:0050662]; glutamate binding [GO:0016595]; glutamate-cysteine ligase activity [GO:0004357]; magnesium ion binding [GO:0000287]; apoptotic mitochondrial changes [GO:0008637]; cell redox homeostasis [GO:0045454]; cellular nitrogen compound metabolic process [GO:0034641]; cysteine metabolic process [GO:0006534]; glutamate metabolic process [GO:0006536]; glutathione biosynthetic process [GO:0006750]; glutathione derivative biosynthetic process [GO:1901687]; L-ascorbic acid metabolic process [GO:0019852]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; regulation of blood vessel size [GO:0050880]; regulation of mitochondrial depolarization [GO:0051900]; response to arsenic-containing substance [GO:0046685]; response to heat [GO:0009408]; response to hormone [GO:0009725]; response to nitrosative stress [GO:0051409]; response to oxidative stress [GO:0006979]; small molecule metabolic process [GO:0044281]; sulfur amino acid metabolic process [GO:0000096]; xenobiotic metabolic process [GO:0006805]	apoptotic mitochondrial changes [GO:0008637]; cell redox homeostasis [GO:0045454]; cellular nitrogen compound metabolic process [GO:0034641]; cysteine metabolic process [GO:0006534]; glutamate metabolic process [GO:0006536]; glutathione biosynthetic process [GO:0006750]; glutathione derivative biosynthetic process [GO:1901687]; L-ascorbic acid metabolic process [GO:0019852]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; regulation of blood vessel size [GO:0050880]; regulation of mitochondrial depolarization [GO:0051900]; response to arsenic-containing substance [GO:0046685]; response to heat [GO:0009408]; response to hormone [GO:0009725]; response to nitrosative stress [GO:0051409]; response to oxidative stress [GO:0006979]; small molecule metabolic process [GO:0044281]; sulfur amino acid metabolic process [GO:0000096]; xenobiotic metabolic process [GO:0006805]	ADP binding [GO:0043531]; ATP binding [GO:0005524]; coenzyme binding [GO:0050662]; glutamate binding [GO:0016595]; glutamate-cysteine ligase activity [GO:0004357]; magnesium ion binding [GO:0000287]	cytosol [GO:0005829]; glutamate-cysteine ligase complex [GO:0017109]	GO:0043531; GO:0005524; GO:0019852; GO:0008637; GO:0045454; GO:0034641; GO:0050662; GO:0006534; GO:0005829; GO:0016595; GO:0006536; GO:0004357; GO:0017109; GO:0006750; GO:1901687; GO:0000287; GO:0043066; GO:2001237; GO:0043524; GO:0031397; GO:0045892; GO:0032436; GO:0050880; GO:0051900; GO:0046685; GO:0009408; GO:0009725; GO:0051409; GO:0006979; GO:0044281; GO:0000096; GO:0006805		ATP-binding; Acetylation; Complete proteome; Disease mutation; Glutathione biosynthesis; Hereditary hemolytic anemia; Ligase; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome	Chain (1); Modified residue (3); Natural variant (5)
NP1L1_HUMAN	P55209	NP1L1_HUMAN	reviewed	Nucleosome assembly protein 1-like 1 (NAP-1-related protein) (hNRP)	NAP1L1 NRP	Homo sapiens (Human)	391	melanosome [GO:0042470]; membrane [GO:0016020]; nucleus [GO:0005634]; poly(A) RNA binding [GO:0044822]; DNA replication [GO:0006260]; nucleosome assembly [GO:0006334]; positive regulation of cell proliferation [GO:0008284]	DNA replication [GO:0006260]; nucleosome assembly [GO:0006334]; positive regulation of cell proliferation [GO:0008284]	poly(A) RNA binding [GO:0044822]	melanosome [GO:0042470]; membrane [GO:0016020]; nucleus [GO:0005634]	GO:0006260; GO:0042470; GO:0016020; GO:0006334; GO:0005634; GO:0044822; GO:0008284	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.	Acetylation; Alternative splicing; Complete proteome; Lipoprotein; Methylation; Nucleus; Phosphoprotein; Prenylation; Reference proteome	Alternative sequence (3); Chain (1); Compositional bias (3); Initiator methionine (1); Lipidation (1); Modified residue (7); Motif (1); Propeptide (1)
NDKB_HUMAN	P22392	NDKB_HUMAN	reviewed	Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (C-myc purine-binding transcription factor PUF) (Histidine protein kinase NDKB) (EC 2.7.13.3) (nm23-H2)	NME2 NM23B	Homo sapiens (Human)	152	cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular [GO:0005622]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; ruffle [GO:0001726]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; nucleoside diphosphate kinase activity [GO:0004550]; protein histidine kinase activity [GO:0004673]; sequence-specific DNA binding transcription factor activity [GO:0003700]; activation of mitophagy in response to mitochondrial depolarization [GO:0098779]; cell adhesion [GO:0007155]; CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of apoptotic process [GO:0043066]; nucleobase-containing small molecule interconversion [GO:0015949]; nucleobase-containing small molecule metabolic process [GO:0055086]; nucleoside triphosphate biosynthetic process [GO:0009142]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; purine nucleotide metabolic process [GO:0006163]; pyrimidine nucleotide metabolic process [GO:0006220]; regulation of epidermis development [GO:0045682]; regulation of transcription, DNA-templated [GO:0006355]; small molecule metabolic process [GO:0044281]; transcription, DNA-templated [GO:0006351]; UTP biosynthetic process [GO:0006228]	activation of mitophagy in response to mitochondrial depolarization [GO:0098779]; cell adhesion [GO:0007155]; CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of apoptotic process [GO:0043066]; nucleobase-containing small molecule interconversion [GO:0015949]; nucleobase-containing small molecule metabolic process [GO:0055086]; nucleoside triphosphate biosynthetic process [GO:0009142]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; purine nucleotide metabolic process [GO:0006163]; pyrimidine nucleotide metabolic process [GO:0006220]; regulation of epidermis development [GO:0045682]; regulation of transcription, DNA-templated [GO:0006355]; small molecule metabolic process [GO:0044281]; transcription, DNA-templated [GO:0006351]; UTP biosynthetic process [GO:0006228]	ATP binding [GO:0005524]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; nucleoside diphosphate kinase activity [GO:0004550]; protein histidine kinase activity [GO:0004673]; sequence-specific DNA binding transcription factor activity [GO:0003700]	cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular [GO:0005622]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; ruffle [GO:0001726]	GO:0005524; GO:0006241; GO:0003677; GO:0006183; GO:0006228; GO:0098779; GO:0007155; GO:0071944; GO:0005737; GO:0005829; GO:0070062; GO:0007229; GO:0005622; GO:0030027; GO:0046872; GO:0043066; GO:0015949; GO:0055086; GO:0004550; GO:0009142; GO:0005634; GO:0050679; GO:0045618; GO:0045944; GO:0004673; GO:0006163; GO:0006220; GO:0045682; GO:0006355; GO:0001726; GO:0003700; GO:0044281; GO:0006351	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell projection, lamellipodium. Cell projection, ruffle. Note=Isoform 2 is mainly cytoplasmic and isoform 1 and isoform 2 are excluded from the nucleolus. Colocalizes with ITGB1 and ITGB1BP1 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen but not on vitronectin or laminin substrates.	3D-structure; ATP-binding; Acetylation; Activator; Alternative splicing; Cell projection; Complete proteome; Cytoplasm; DNA-binding; Direct protein sequencing; Kinase; Magnesium; Metal-binding; Nucleotide metabolism; Nucleotide-binding; Nucleus; Reference proteome; Transcription; Transcription regulation; Transferase	Active site (1); Alternative sequence (1); Beta strand (4); Binding site (6); Chain (1); Helix (12); Modified residue (1); Region (1)
NSUN5_HUMAN	Q96P11	NSUN5_HUMAN	reviewed	Probable 28S rRNA (cytosine-C(5))-methyltransferase (EC 2.1.1.-) (NOL1-related protein) (NOL1R) (NOL1/NOP2/Sun domain family member 5) (Williams-Beuren syndrome chromosomal region 20A protein)	NSUN5 NSUN5A WBSCR20 WBSCR20A	Homo sapiens (Human)	429	nucleolus [GO:0005730]; nucleus [GO:0005634]; methyltransferase activity [GO:0008168]; poly(A) RNA binding [GO:0044822]; rRNA processing [GO:0006364]	rRNA processing [GO:0006364]	methyltransferase activity [GO:0008168]; poly(A) RNA binding [GO:0044822]	nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0008168; GO:0005730; GO:0005634; GO:0044822; GO:0006364		3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Methyltransferase; Phosphoprotein; Polymorphism; RNA-binding; Reference proteome; S-adenosyl-L-methionine; Transferase; Williams-Beuren syndrome; rRNA processing	Active site (1); Alternative sequence (7); Beta strand (15); Binding site (3); Chain (1); Helix (14); Initiator methionine (1); Modified residue (2); Natural variant (1); Region (1); Sequence conflict (3); Turn (2)
WDR26_HUMAN	Q9H7D7	WDR26_HUMAN	reviewed	WD repeat-containing protein 26 (CUL4- and DDB1-associated WDR protein 2) (Myocardial ischemic preconditioning up-regulated protein 2)	WDR26 CDW2 MIP2 PRO0852	Homo sapiens (Human)	661	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]			cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]	GO:0005737; GO:0005654	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15378603}.	Alternative splicing; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome; Repeat; WD repeat	Alternative sequence (5); Chain (1); Domain (2); Erroneous initiation (7); Erroneous termination (1); Modified residue (2); Repeat (6); Sequence conflict (1)
RUXGL_HUMAN	A8MWD9	RUXGL_HUMAN	reviewed	Putative small nuclear ribonucleoprotein G-like protein 15	SNRPGP15	Homo sapiens (Human)	76	small nucleolar ribonucleoprotein complex [GO:0005732]; spliceosomal complex [GO:0005681]; RNA binding [GO:0003723]; mRNA splicing, via spliceosome [GO:0000398]	mRNA splicing, via spliceosome [GO:0000398]	RNA binding [GO:0003723]	small nucleolar ribonucleoprotein complex [GO:0005732]; spliceosomal complex [GO:0005681]	GO:0003723; GO:0000398; GO:0005732; GO:0005681	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.	Complete proteome; Nucleus; RNA-binding; Reference proteome; Ribonucleoprotein; Spliceosome; mRNA processing; mRNA splicing	Chain (1); Sequence conflict (3)
G3V5X9_HUMAN	G3V5X9	G3V5X9_HUMAN	unreviewed	Sorting nexin-6 (Fragment)	SNX6	Homo sapiens (Human)	239	endosome [GO:0005768]; extrinsic component of membrane [GO:0019898]; intracellular membrane-bounded organelle [GO:0043231]; phosphatidylinositol binding [GO:0035091]; endocytosis [GO:0006897]; intracellular protein transport [GO:0006886]; vesicle organization [GO:0016050]	endocytosis [GO:0006897]; intracellular protein transport [GO:0006886]; vesicle organization [GO:0016050]	phosphatidylinositol binding [GO:0035091]	endosome [GO:0005768]; extrinsic component of membrane [GO:0019898]; intracellular membrane-bounded organelle [GO:0043231]	GO:0006897; GO:0005768; GO:0019898; GO:0043231; GO:0006886; GO:0035091; GO:0016050		Complete proteome; Proteomics identification; Reference proteome	Non-terminal residue (1)
SORCN_HUMAN	P30626	SORCN_HUMAN	reviewed	Sorcin (22 kDa protein) (CP-22) (CP22) (V19)	SRI	Homo sapiens (Human)	198	axon terminus [GO:0043679]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine neck [GO:0044326]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; smooth endoplasmic reticulum [GO:0005790]; T-tubule [GO:0030315]; Z disc [GO:0030018]; calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; ion channel binding [GO:0044325]; protease binding [GO:0002020]; protein heterodimerization activity [GO:0046982]; receptor binding [GO:0005102]; action potential [GO:0001508]; calcium ion transport [GO:0006816]; cytoplasmic sequestering of transcription factor [GO:0042994]; heart development [GO:0007507]; intracellular sequestering of iron ion [GO:0006880]; muscle organ development [GO:0007517]; negative regulation of heart rate [GO:0010459]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; negative regulation of transcription regulatory region DNA binding [GO:2000678]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; proteolysis [GO:0006508]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cell communication by electrical coupling [GO:0010649]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of heart contraction [GO:0008016]; regulation of high voltage-gated calcium channel activity [GO:1901841]; regulation of relaxation of muscle [GO:1901077]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of striated muscle contraction [GO:0006942]; signal transduction [GO:0007165]; transport [GO:0006810]	action potential [GO:0001508]; calcium ion transport [GO:0006816]; cytoplasmic sequestering of transcription factor [GO:0042994]; heart development [GO:0007507]; intracellular sequestering of iron ion [GO:0006880]; muscle organ development [GO:0007517]; negative regulation of heart rate [GO:0010459]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; negative regulation of transcription regulatory region DNA binding [GO:2000678]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; proteolysis [GO:0006508]; regulation of calcium ion transport [GO:0051924]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of cell communication by electrical coupling [GO:0010649]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of heart contraction [GO:0008016]; regulation of high voltage-gated calcium channel activity [GO:1901841]; regulation of relaxation of muscle [GO:1901077]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of striated muscle contraction [GO:0006942]; signal transduction [GO:0007165]; transport [GO:0006810]	calcium channel regulator activity [GO:0005246]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; calcium ion binding [GO:0005509]; ion channel binding [GO:0044325]; protease binding [GO:0002020]; protein heterodimerization activity [GO:0046982]; receptor binding [GO:0005102]	axon terminus [GO:0043679]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine neck [GO:0044326]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; smooth endoplasmic reticulum [GO:0005790]; T-tubule [GO:0030315]; Z disc [GO:0030018]	GO:0030315; GO:0030018; GO:0001508; GO:0043679; GO:0005246; GO:0005509; GO:0006816; GO:0004198; GO:0005737; GO:0042994; GO:0005829; GO:0044326; GO:0005789; GO:0070062; GO:0007507; GO:0006880; GO:0044325; GO:0016020; GO:0005739; GO:0007517; GO:0010459; GO:0060315; GO:2000678; GO:0005654; GO:0035774; GO:0051281; GO:0002020; GO:0046982; GO:0006508; GO:0005102; GO:0051924; GO:0086004; GO:0010649; GO:1901844; GO:0008016; GO:1901841; GO:1901077; GO:0010880; GO:0006942; GO:0016529; GO:0033017; GO:0007165; GO:0005790; GO:0006810	SUBCELLULAR LOCATION: Cytoplasm. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=Relocates to the sarcoplasmic reticulum membrane in response to elevated calcium levels.	3D-structure; Alternative splicing; Calcium; Complete proteome; Cytoplasm; Direct protein sequencing; Membrane; Metal-binding; Reference proteome; Repeat; Sarcoplasmic reticulum	Alternative sequence (2); Beta strand (4); Calcium binding (2); Chain (1); Domain (4); Helix (9); Mutagenesis (1); Turn (2)
C9J0K6_HUMAN	C9J0K6	C9J0K6_HUMAN	unreviewed	Sorcin	SRI	Homo sapiens (Human)	155	calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; proteolysis [GO:0006508]	proteolysis [GO:0006508]	calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; calcium ion binding [GO:0005509]		GO:0005509; GO:0004198; GO:0006508		Calcium; Complete proteome; Proteomics identification; Reference proteome	
SURF4_HUMAN	O15260	SURF4_HUMAN	reviewed	Surfeit locus protein 4	SURF4 SURF-4	Homo sapiens (Human)	269	endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; Golgi organization [GO:0007030]; positive regulation of organelle organization [GO:0010638]	Golgi organization [GO:0007030]; positive regulation of organelle organization [GO:0010638]		endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]	GO:0000139; GO:0007030; GO:0005789; GO:0005793; GO:0033116; GO:0016021; GO:0010638	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Cycles between the endoplasmic reticulum and the Golgi.	Alternative splicing; Complete proteome; Endoplasmic reticulum; Golgi apparatus; Membrane; Reference proteome; Transmembrane; Transmembrane helix	Alternative sequence (4); Chain (1); Motif (1); Mutagenesis (1); Sequence conflict (1); Transmembrane (5)
PTBP1_HUMAN	P26599	PTBP1_HUMAN	reviewed	Polypyrimidine tract-binding protein 1 (PTB) (57 kDa RNA-binding protein PPTB-1) (Heterogeneous nuclear ribonucleoprotein I) (hnRNP I)	PTBP1 PTB	Homo sapiens (Human)	531	extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; poly-pyrimidine tract binding [GO:0008187]; pre-mRNA binding [GO:0036002]; RNA binding [GO:0003723]; alternative mRNA splicing, via spliceosome [GO:0000380]; gene expression [GO:0010467]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of muscle cell differentiation [GO:0051148]; negative regulation of RNA splicing [GO:0033119]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]	alternative mRNA splicing, via spliceosome [GO:0000380]; gene expression [GO:0010467]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of muscle cell differentiation [GO:0051148]; negative regulation of RNA splicing [GO:0033119]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]	nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; poly-pyrimidine tract binding [GO:0008187]; pre-mRNA binding [GO:0036002]; RNA binding [GO:0003723]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]	GO:0003723; GO:0008380; GO:0000380; GO:0070062; GO:0010467; GO:0006397; GO:0000398; GO:0016020; GO:0033119; GO:0048025; GO:0051148; GO:0005730; GO:0005654; GO:0000166; GO:0044822; GO:0008187; GO:0036002; GO:0000381	SUBCELLULAR LOCATION: Nucleus.	3D-structure; Acetylation; Activator; Alternative splicing; Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein; RNA-binding; Reference proteome; Repeat; Repressor; mRNA processing; mRNA splicing	Alternative sequence (2); Beta strand (26); Chain (1); Compositional bias (1); Domain (4); Helix (11); Modified residue (5); Turn (6)
RL5_HUMAN	P46777	RL5_HUMAN	reviewed	60S ribosomal protein L5	RPL5 MSTP030	Homo sapiens (Human)	297	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]; 5S rRNA binding [GO:0008097]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	5S rRNA binding [GO:0008097]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]	GO:0008097; GO:0003723; GO:0006614; GO:0044267; GO:0005737; GO:0005829; GO:0022625; GO:0070062; GO:0005925; GO:0010467; GO:0016020; GO:0000184; GO:0005730; GO:0005634; GO:0044822; GO:0006364; GO:0030529; GO:0042273; GO:0003735; GO:0006412; GO:0006414; GO:0006413; GO:0006415; GO:0019058; GO:0016032; GO:0019083	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|Ref.7}. Nucleus, nucleolus {ECO:0000269|Ref.7}.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Diamond-Blackfan anemia; Direct protein sequencing; Disease mutation; Nucleus; Phosphoprotein; Polymorphism; RNA-binding; Reference proteome; Ribonucleoprotein; Ribosomal protein; rRNA-binding	Chain (1); Initiator methionine (1); Modified residue (5); Natural variant (3); Sequence conflict (3)
H0YCK3_HUMAN	H0YCK3	H0YCK3_HUMAN	unreviewed	Double-stranded RNA-specific adenosine deaminase (Fragment)	ADAR	Homo sapiens (Human)	1195	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; double-stranded RNA adenosine deaminase activity [GO:0003726]; RNA binding [GO:0003723]; RNA processing [GO:0006396]	RNA processing [GO:0006396]	double-stranded RNA adenosine deaminase activity [GO:0003726]; RNA binding [GO:0003723]	nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003723; GO:0006396; GO:0003726; GO:0005730; GO:0005654; GO:0005634		Complete proteome; Proteomics identification; Reference proteome	Non-terminal residue (2)
ATIF1_HUMAN	Q9UII2	ATIF1_HUMAN	reviewed	ATPase inhibitor, mitochondrial (Inhibitor of F(1)F(o)-ATPase) (IF(1)) (IF1)	ATPIF1 ATPI	Homo sapiens (Human)	106	cell surface [GO:0009986]; mitochondrion [GO:0005739]; angiostatin binding [GO:0043532]; ATPase binding [GO:0051117]; ATPase inhibitor activity [GO:0042030]; calmodulin binding [GO:0005516]; enzyme inhibitor activity [GO:0004857]; protein homodimerization activity [GO:0042803]; activation of mitophagy in response to mitochondrial depolarization [GO:0098779]; angiogenesis [GO:0001525]; erythrocyte differentiation [GO:0030218]; generation of precursor metabolites and energy [GO:0006091]; heme biosynthetic process [GO:0006783]; mitochondrial depolarization [GO:0051882]; negative regulation of ATPase activity [GO:0032780]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of hydrolase activity [GO:0051346]; negative regulation of nucleotide metabolic process [GO:0045980]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of proteolysis involved in cellular protein catabolic process [GO:1903052]; protein homooligomerization [GO:0051260]; protein homotetramerization [GO:0051289]; reactive oxygen species metabolic process [GO:0072593]; regulation of ATP metabolic process [GO:1903578]; regulation of protein targeting to mitochondrion [GO:1903214]	activation of mitophagy in response to mitochondrial depolarization [GO:0098779]; angiogenesis [GO:0001525]; erythrocyte differentiation [GO:0030218]; generation of precursor metabolites and energy [GO:0006091]; heme biosynthetic process [GO:0006783]; mitochondrial depolarization [GO:0051882]; negative regulation of ATPase activity [GO:0032780]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of hydrolase activity [GO:0051346]; negative regulation of nucleotide metabolic process [GO:0045980]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of proteolysis involved in cellular protein catabolic process [GO:1903052]; protein homooligomerization [GO:0051260]; protein homotetramerization [GO:0051289]; reactive oxygen species metabolic process [GO:0072593]; regulation of ATP metabolic process [GO:1903578]; regulation of protein targeting to mitochondrion [GO:1903214]	angiostatin binding [GO:0043532]; ATPase binding [GO:0051117]; ATPase inhibitor activity [GO:0042030]; calmodulin binding [GO:0005516]; enzyme inhibitor activity [GO:0004857]; protein homodimerization activity [GO:0042803]	cell surface [GO:0009986]; mitochondrion [GO:0005739]	GO:0051117; GO:0042030; GO:0098779; GO:0001525; GO:0043532; GO:0005516; GO:0009986; GO:0004857; GO:0030218; GO:0006091; GO:0006783; GO:0051882; GO:0005739; GO:0032780; GO:0001937; GO:0051346; GO:0045980; GO:1901030; GO:1903052; GO:0042803; GO:0051260; GO:0051289; GO:0072593; GO:1903578; GO:1903214	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:12110673}.	Alternative splicing; Coiled coil; Complete proteome; Direct protein sequencing; Mitochondrion; Reference proteome; Transit peptide	Alternative sequence (2); Chain (1); Coiled coil (1); Erroneous initiation (1); Modified residue (1); Region (2); Sequence conflict (1); Transit peptide (1)
MESH1_HUMAN	Q8N4P3	MESH1_HUMAN	reviewed	Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (HD domain-containing protein 3) (Metazoan SpoT homolog 1) (MESH1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) ((ppGpp)ase)	HDDC3 MESH1	Homo sapiens (Human)	179	guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity [GO:0008893]; metal ion binding [GO:0046872]		guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity [GO:0008893]; metal ion binding [GO:0046872]		GO:0008893; GO:0046872		3D-structure; Acetylation; Alternative splicing; Complete proteome; Hydrolase; Manganese; Metal-binding; Reference proteome	Active site (2); Alternative sequence (2); Chain (1); Domain (1); Helix (10); Initiator methionine (1); Metal binding (4); Modified residue (4); Mutagenesis (3); Turn (2)
H0YNP9_HUMAN	H0YNP9	H0YNP9_HUMAN	unreviewed	Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1	HDDC3	Homo sapiens (Human)	143							Complete proteome; Proteomics identification; Reference proteome	
RRP12_HUMAN	Q5JTH9	RRP12_HUMAN	reviewed	RRP12-like protein	RRP12 KIAA0690	Homo sapiens (Human)	1297	integral component of membrane [GO:0016021]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; poly(A) RNA binding [GO:0044822]		poly(A) RNA binding [GO:0044822]	integral component of membrane [GO:0016021]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]	GO:0016021; GO:0031965; GO:0005730; GO:0044822	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}. Nucleus membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.	Alternative splicing; Complete proteome; Membrane; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix	Alternative sequence (2); Chain (1); Compositional bias (1); Erroneous initiation (1); Modified residue (5); Natural variant (2); Sequence conflict (3); Transmembrane (1)
RPRD2_HUMAN	Q5VT52	RPRD2_HUMAN	reviewed	Regulation of nuclear pre-mRNA domain-containing protein 2	RPRD2 KIAA0460 HSPC099	Homo sapiens (Human)	1461	DNA-directed RNA polymerase II, holoenzyme [GO:0016591]			DNA-directed RNA polymerase II, holoenzyme [GO:0016591]	GO:0016591		3D-structure; Alternative splicing; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome	Alternative sequence (6); Chain (1); Compositional bias (5); Domain (1); Erroneous initiation (2); Helix (9); Modified residue (24); Natural variant (1); Sequence conflict (4); Turn (2)
NEUL_HUMAN	Q9BYT8	NEUL_HUMAN	reviewed	Neurolysin, mitochondrial (EC 3.4.24.16) (Angiotensin-binding protein) (Microsomal endopeptidase) (MEP) (Mitochondrial oligopeptidase M) (Neurotensin endopeptidase)	NLN AGTBP KIAA1226	Homo sapiens (Human)	704	mitochondrial intermembrane space [GO:0005758]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; peptide binding [GO:0042277]		metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; peptide binding [GO:0042277]	mitochondrial intermembrane space [GO:0005758]; plasma membrane [GO:0005886]	GO:0046872; GO:0004222; GO:0005758; GO:0042277; GO:0005886	SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000250}. Cytoplasm {ECO:0000250}.	Acetylation; Complete proteome; Cytoplasm; Hydrolase; Metal-binding; Metalloprotease; Mitochondrion; Polymorphism; Protease; Reference proteome; Transit peptide; Zinc	Active site (1); Chain (1); Metal binding (3); Modified residue (1); Natural variant (5); Transit peptide (1)
SCOT1_HUMAN	P55809	SCOT1_HUMAN	reviewed	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (EC 2.8.3.5) (3-oxoacid CoA-transferase 1) (Somatic-type succinyl-CoA:3-oxoacid CoA-transferase) (SCOT-s)	OXCT1 OXCT SCOT	Homo sapiens (Human)	520	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; 3-oxoacid CoA-transferase activity [GO:0008260]; protein homodimerization activity [GO:0042803]; adipose tissue development [GO:0060612]; brain development [GO:0007420]; cellular ketone body metabolic process [GO:0046950]; cellular lipid metabolic process [GO:0044255]; heart development [GO:0007507]; ketone body catabolic process [GO:0046952]; ketone catabolic process [GO:0042182]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; response to activity [GO:0014823]; response to drug [GO:0042493]; response to ethanol [GO:0045471]; response to hormone [GO:0009725]; response to nutrient [GO:0007584]; response to starvation [GO:0042594]; small molecule metabolic process [GO:0044281]	adipose tissue development [GO:0060612]; brain development [GO:0007420]; cellular ketone body metabolic process [GO:0046950]; cellular lipid metabolic process [GO:0044255]; heart development [GO:0007507]; ketone body catabolic process [GO:0046952]; ketone catabolic process [GO:0042182]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; response to activity [GO:0014823]; response to drug [GO:0042493]; response to ethanol [GO:0045471]; response to hormone [GO:0009725]; response to nutrient [GO:0007584]; response to starvation [GO:0042594]; small molecule metabolic process [GO:0044281]	3-oxoacid CoA-transferase activity [GO:0008260]; protein homodimerization activity [GO:0042803]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0008260; GO:0060612; GO:0007420; GO:0046950; GO:0044255; GO:0007507; GO:0046952; GO:0042182; GO:0005759; GO:0005739; GO:0035774; GO:0042803; GO:0014823; GO:0042493; GO:0045471; GO:0009725; GO:0007584; GO:0042594; GO:0044281	SUBCELLULAR LOCATION: Mitochondrion matrix.	3D-structure; Alternative splicing; Complete proteome; Direct protein sequencing; Disease mutation; Mitochondrion; Phosphoprotein; Polymorphism; Reference proteome; Transferase; Transit peptide	Active site (1); Alternative sequence (1); Beta strand (30); Chain (1); Helix (19); Modified residue (5); Natural variant (12); Sequence conflict (1); Transit peptide (1); Turn (4)
ANXA2_HUMAN	P07355	ANXA2_HUMAN	reviewed	Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36)	ANXA2 ANX2 ANX2L4 CAL1H LPC2D	Homo sapiens (Human)	339	basement membrane [GO:0005604]; basolateral plasma membrane [GO:0016323]; cell cortex [GO:0005938]; cell surface [GO:0009986]; early endosome [GO:0005769]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; extrinsic component of plasma membrane [GO:0019897]; late endosome membrane [GO:0031902]; lipid particle [GO:0005811]; lysosomal membrane [GO:0005765]; macropinosome [GO:0044354]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; myelin sheath adaxonal region [GO:0035749]; nucleus [GO:0005634]; PCSK9-AnxA2 complex [GO:1990667]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; sarcolemma [GO:0042383]; Schmidt-Lanterman incisure [GO:0043220]; vesicle [GO:0031982]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phospholipase A2 inhibitor activity [GO:0019834]; poly(A) RNA binding [GO:0044822]; S100 protein binding [GO:0044548]; angiogenesis [GO:0001525]; body fluid secretion [GO:0007589]; collagen fibril organization [GO:0030199]; fibrinolysis [GO:0042730]; membrane budding [GO:0006900]; membrane raft assembly [GO:0001765]; negative regulation of catalytic activity [GO:0043086]; negative regulation of low-density lipoprotein particle receptor catabolic process [GO:0032804]; negative regulation of receptor binding [GO:1900121]; negative regulation of receptor internalization [GO:0002091]; osteoclast development [GO:0036035]; positive regulation of binding [GO:0051099]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor activity [GO:2000273]; positive regulation of vesicle fusion [GO:0031340]; protein heterotetramerization [GO:0051290]; protein targeting to plasma membrane [GO:0072661]	angiogenesis [GO:0001525]; body fluid secretion [GO:0007589]; collagen fibril organization [GO:0030199]; fibrinolysis [GO:0042730]; membrane budding [GO:0006900]; membrane raft assembly [GO:0001765]; negative regulation of catalytic activity [GO:0043086]; negative regulation of low-density lipoprotein particle receptor catabolic process [GO:0032804]; negative regulation of receptor binding [GO:1900121]; negative regulation of receptor internalization [GO:0002091]; osteoclast development [GO:0036035]; positive regulation of binding [GO:0051099]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor activity [GO:2000273]; positive regulation of vesicle fusion [GO:0031340]; protein heterotetramerization [GO:0051290]; protein targeting to plasma membrane [GO:0072661]	calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; calcium ion binding [GO:0005509]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phospholipase A2 inhibitor activity [GO:0019834]; poly(A) RNA binding [GO:0044822]; S100 protein binding [GO:0044548]	basement membrane [GO:0005604]; basolateral plasma membrane [GO:0016323]; cell cortex [GO:0005938]; cell surface [GO:0009986]; early endosome [GO:0005769]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; extrinsic component of plasma membrane [GO:0019897]; late endosome membrane [GO:0031902]; lipid particle [GO:0005811]; lysosomal membrane [GO:0005765]; macropinosome [GO:0044354]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; myelin sheath adaxonal region [GO:0035749]; nucleus [GO:0005634]; PCSK9-AnxA2 complex [GO:1990667]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; sarcolemma [GO:0042383]; Schmidt-Lanterman incisure [GO:0043220]; vesicle [GO:0031982]	GO:1990667; GO:0044548; GO:0043220; GO:0001525; GO:0005604; GO:0016323; GO:0007589; GO:0005509; GO:0005544; GO:0048306; GO:0005938; GO:0009986; GO:0030199; GO:0005769; GO:0005768; GO:0070062; GO:0005615; GO:0019897; GO:0042730; GO:0031902; GO:0005811; GO:0005765; GO:0044354; GO:0042470; GO:0016020; GO:0006900; GO:0001765; GO:0030496; GO:0035749; GO:0043086; GO:0032804; GO:1900121; GO:0002091; GO:0005634; GO:0036035; GO:0048471; GO:0005546; GO:0019834; GO:0005886; GO:0044822; GO:0051099; GO:0048146; GO:0001934; GO:2000273; GO:0031340; GO:0051290; GO:0072661; GO:0001726; GO:0042383; GO:0031982	SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism.	3D-structure; Acetylation; Alternative splicing; Annexin; Basement membrane; Calcium; Calcium/phospholipid-binding; Complete proteome; Direct protein sequencing; Extracellular matrix; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Secreted; Ubl conjugation	Alternative sequence (1); Beta strand (3); Chain (1); Erroneous initiation (1); Helix (21); Initiator methionine (1); Modified residue (7); Mutagenesis (1); Natural variant (1); Region (1); Repeat (4); Sequence conflict (3); Turn (3)
NCOR1_HUMAN	O75376	NCOR1_HUMAN	reviewed	Nuclear receptor corepressor 1 (N-CoR) (N-CoR1)	NCOR1 KIAA1047	Homo sapiens (Human)	2440	cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear chromatin [GO:0000790]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle microtubule [GO:0005876]; transcription factor complex [GO:0005667]; transcriptional repressor complex [GO:0017053]; chromatin binding [GO:0003682]; histone deacetylase binding [GO:0042826]; histone deacetylase regulator activity [GO:0035033]; nuclear hormone receptor binding [GO:0035257]; RNA polymerase II activating transcription factor binding [GO:0001102]; sequence-specific DNA binding [GO:0043565]; sequence-specific DNA binding transcription factor activity [GO:0003700]; transcription corepressor activity [GO:0003714]; transcription regulatory region DNA binding [GO:0044212]; CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0002361]; cellular lipid metabolic process [GO:0044255]; cholesterol homeostasis [GO:0042632]; chromatin modification [GO:0016568]; chromatin organization [GO:0006325]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; definitive erythrocyte differentiation [GO:0060318]; gene expression [GO:0010467]; negative regulation of JNK cascade [GO:0046329]; negative regulation of phosphatidylinositol 3-kinase signaling [GO:0014067]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; Notch signaling pathway [GO:0007219]; positive regulation of histone deacetylation [GO:0031065]; regulation of fatty acid transport [GO:2000191]; regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter [GO:0072362]; regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter [GO:0072368]; regulation of multicellular organism growth [GO:0040014]; small molecule metabolic process [GO:0044281]; spindle assembly [GO:0051225]; thalamus development [GO:0021794]; transcription from RNA polymerase II promoter [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]; transcription, DNA-templated [GO:0006351]; transforming growth factor beta receptor signaling pathway [GO:0007179]	CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [GO:0002361]; cellular lipid metabolic process [GO:0044255]; cholesterol homeostasis [GO:0042632]; chromatin modification [GO:0016568]; chromatin organization [GO:0006325]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; definitive erythrocyte differentiation [GO:0060318]; gene expression [GO:0010467]; negative regulation of JNK cascade [GO:0046329]; negative regulation of phosphatidylinositol 3-kinase signaling [GO:0014067]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; Notch signaling pathway [GO:0007219]; positive regulation of histone deacetylation [GO:0031065]; regulation of fatty acid transport [GO:2000191]; regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter [GO:0072362]; regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter [GO:0072368]; regulation of multicellular organism growth [GO:0040014]; small molecule metabolic process [GO:0044281]; spindle assembly [GO:0051225]; thalamus development [GO:0021794]; transcription, DNA-templated [GO:0006351]; transcription from RNA polymerase II promoter [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]; transforming growth factor beta receptor signaling pathway [GO:0007179]	chromatin binding [GO:0003682]; histone deacetylase binding [GO:0042826]; histone deacetylase regulator activity [GO:0035033]; nuclear hormone receptor binding [GO:0035257]; RNA polymerase II activating transcription factor binding [GO:0001102]; sequence-specific DNA binding [GO:0043565]; sequence-specific DNA binding transcription factor activity [GO:0003700]; transcription corepressor activity [GO:0003714]; transcription regulatory region DNA binding [GO:0044212]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear chromatin [GO:0000790]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle microtubule [GO:0005876]; transcriptional repressor complex [GO:0017053]; transcription factor complex [GO:0005667]	GO:0002361; GO:0007219; GO:0001102; GO:0044255; GO:0042632; GO:0003682; GO:0016568; GO:0006325; GO:0032922; GO:0007623; GO:0005737; GO:0060318; GO:0010467; GO:0042826; GO:0035033; GO:0016020; GO:0046329; GO:0014067; GO:0000122; GO:0000790; GO:0035257; GO:0005654; GO:0005634; GO:0031065; GO:2000191; GO:0072362; GO:0072368; GO:0040014; GO:0043565; GO:0003700; GO:0044281; GO:0051225; GO:0005876; GO:0021794; GO:0003714; GO:0005667; GO:0006366; GO:0006367; GO:0044212; GO:0006351; GO:0017053; GO:0007179	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624}.	3D-structure; Acetylation; Alternative splicing; Chromatin regulator; Coiled coil; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Ubl conjugation	Alternative sequence (5); Beta strand (1); Chain (1); Coiled coil (3); Compositional bias (6); Domain (2); Erroneous initiation (1); Helix (5); Modified residue (15); Motif (3); Region (7); Sequence conflict (10)
RUVB1_HUMAN	Q9Y265	RUVB1_HUMAN	reviewed	RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha)	RUVBL1 INO80H NMP238 TIP49 TIP49A	Homo sapiens (Human)	456	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Ino80 complex [GO:0031011]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; MLL1 complex [GO:0071339]; NuA4 histone acetyltransferase complex [GO:0035267]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Swr1 complex [GO:0000812]; ATP binding [GO:0005524]; DNA helicase activity [GO:0003678]; cell division [GO:0051301]; CENP-A containing nucleosome assembly [GO:0034080]; chromatin organization [GO:0006325]; DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; histone H2A acetylation [GO:0043968]; histone H4 acetylation [GO:0043967]; mitotic nuclear division [GO:0007067]; nucleosome assembly [GO:0006334]; positive regulation of protein targeting to mitochondrion [GO:1903955]; regulation of growth [GO:0040008]; regulation of mitochondrion degradation [GO:1903146]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; spermatogenesis [GO:0007283]; transcription, DNA-templated [GO:0006351]	cell division [GO:0051301]; CENP-A containing nucleosome assembly [GO:0034080]; chromatin organization [GO:0006325]; DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; histone H2A acetylation [GO:0043968]; histone H4 acetylation [GO:0043967]; mitotic nuclear division [GO:0007067]; nucleosome assembly [GO:0006334]; positive regulation of protein targeting to mitochondrion [GO:1903955]; regulation of growth [GO:0040008]; regulation of mitochondrion degradation [GO:1903146]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; spermatogenesis [GO:0007283]; transcription, DNA-templated [GO:0006351]	ATP binding [GO:0005524]; DNA helicase activity [GO:0003678]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Ino80 complex [GO:0031011]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; MLL1 complex [GO:0071339]; NuA4 histone acetyltransferase complex [GO:0035267]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Swr1 complex [GO:0000812]	GO:0005524; GO:0034080; GO:0032508; GO:0003678; GO:0006310; GO:0006281; GO:0005794; GO:0031011; GO:0071339; GO:0035267; GO:0000812; GO:0051301; GO:0006325; GO:0005737; GO:0070062; GO:0043968; GO:0043967; GO:0043231; GO:0016020; GO:0005815; GO:0007067; GO:0016363; GO:0005654; GO:0006334; GO:0005634; GO:1903955; GO:0040008; GO:1903146; GO:0006357; GO:0007283; GO:0006351	SUBCELLULAR LOCATION: Nucleus matrix. Nucleus, nucleoplasm. Cytoplasm. Membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Mainly localized in the nucleus, associated with nuclear matrix or in the nuclear cytosol, although it is also present in the cytoplasm and associated with the cell membranes. In prophase and prometaphase it is located at the centrosome and the branching microtubule spindles. After mitotic nuclear membrane disintigration it accumulates at the centrosome and sites of tubulin polymerization. As cells pass through metaphase and into telophase it is located close to the centrosome at the early phase of tubulin polymerization. In anaphase it accumulates at the zone of tubule interdigitation. In telophase it is found at polar tubule overlap, and it reappears at the site of chromosomal decondensation in the daughter cells.	3D-structure; ATP-binding; Acetylation; Activator; Alternative splicing; Cell cycle; Cell division; Chromatin regulator; Complete proteome; Cytoplasm; Cytoskeleton; DNA damage; DNA recombination; DNA repair; Direct protein sequencing; Growth regulation; Helicase; Hydrolase; Membrane; Mitosis; Nucleotide-binding; Nucleus; Reference proteome; Transcription; Transcription regulation	Alternative sequence (2); Beta strand (21); Chain (1); Helix (17); Modified residue (1); Mutagenesis (1); Nucleotide binding (1); Sequence conflict (4); Turn (2)
C9JEH3_HUMAN	C9JEH3	C9JEH3_HUMAN	unreviewed	Angio-associated migratory cell protein (Angio-associated, migratory cell protein, isoform CRA_a)	AAMP hCG_16292	Homo sapiens (Human)	435							Complete proteome; Proteomics identification; Reference proteome; Repeat; WD repeat	
LIS1_HUMAN	P43034	LIS1_HUMAN	reviewed	Platelet-activating factor acetylhydrolase IB subunit alpha (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha)	PAFAH1B1 LIS1 MDCR MDS PAFAHA	Homo sapiens (Human)	410	astral microtubule [GO:0000235]; axon [GO:0030424]; cell cortex [GO:0005938]; cell leading edge [GO:0031252]; centrosome [GO:0005813]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; growth cone [GO:0030426]; kinesin complex [GO:0005871]; kinetochore [GO:0000776]; microtubule associated complex [GO:0005875]; motile primary cilium [GO:0031512]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; perinuclear region of cytoplasm [GO:0048471]; dynactin binding [GO:0034452]; dynein binding [GO:0045502]; heparin binding [GO:0008201]; microtubule binding [GO:0008017]; phospholipase binding [GO:0043274]; phosphoprotein binding [GO:0051219]; protein homodimerization activity [GO:0042803]; acrosome assembly [GO:0001675]; actin cytoskeleton organization [GO:0030036]; adult locomotory behavior [GO:0008344]; ameboidal-type cell migration [GO:0001667]; brain morphogenesis [GO:0048854]; cerebral cortex development [GO:0021987]; cerebral cortex neuron differentiation [GO:0021895]; corpus callosum morphogenesis [GO:0021540]; establishment of centrosome localization [GO:0051660]; establishment of mitotic spindle orientation [GO:0000132]; G2/M transition of mitotic cell cycle [GO:0000086]; hippocampus development [GO:0021766]; layer formation in cerebral cortex [GO:0021819]; learning or memory [GO:0007611]; lipid catabolic process [GO:0016042]; microtubule cytoskeleton organization [GO:0000226]; microtubule organizing center organization [GO:0031023]; microtubule-based process [GO:0007017]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; negative regulation of JNK cascade [GO:0046329]; negative regulation of neuron projection development [GO:0010977]; neuroblast proliferation [GO:0007405]; neuromuscular process controlling balance [GO:0050885]; neuron migration [GO:0001764]; nuclear envelope disassembly [GO:0051081]; nuclear migration [GO:0007097]; organelle organization [GO:0006996]; osteoclast development [GO:0036035]; platelet activating factor metabolic process [GO:0046469]; positive regulation of axon extension [GO:0045773]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of mitotic cell cycle [GO:0045931]; protein secretion [GO:0009306]; retrograde axon cargo transport [GO:0008090]; small GTPase mediated signal transduction [GO:0007264]; stem cell division [GO:0017145]; synaptic transmission [GO:0007268]; transmission of nerve impulse [GO:0019226]; vesicle transport along microtubule [GO:0047496]	acrosome assembly [GO:0001675]; actin cytoskeleton organization [GO:0030036]; adult locomotory behavior [GO:0008344]; ameboidal-type cell migration [GO:0001667]; brain morphogenesis [GO:0048854]; cerebral cortex development [GO:0021987]; cerebral cortex neuron differentiation [GO:0021895]; corpus callosum morphogenesis [GO:0021540]; establishment of centrosome localization [GO:0051660]; establishment of mitotic spindle orientation [GO:0000132]; G2/M transition of mitotic cell cycle [GO:0000086]; hippocampus development [GO:0021766]; layer formation in cerebral cortex [GO:0021819]; learning or memory [GO:0007611]; lipid catabolic process [GO:0016042]; microtubule-based process [GO:0007017]; microtubule cytoskeleton organization [GO:0000226]; microtubule organizing center organization [GO:0031023]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; negative regulation of JNK cascade [GO:0046329]; negative regulation of neuron projection development [GO:0010977]; neuroblast proliferation [GO:0007405]; neuromuscular process controlling balance [GO:0050885]; neuron migration [GO:0001764]; nuclear envelope disassembly [GO:0051081]; nuclear migration [GO:0007097]; organelle organization [GO:0006996]; osteoclast development [GO:0036035]; platelet activating factor metabolic process [GO:0046469]; positive regulation of axon extension [GO:0045773]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of mitotic cell cycle [GO:0045931]; protein secretion [GO:0009306]; retrograde axon cargo transport [GO:0008090]; small GTPase mediated signal transduction [GO:0007264]; stem cell division [GO:0017145]; synaptic transmission [GO:0007268]; transmission of nerve impulse [GO:0019226]; vesicle transport along microtubule [GO:0047496]	dynactin binding [GO:0034452]; dynein binding [GO:0045502]; heparin binding [GO:0008201]; microtubule binding [GO:0008017]; phospholipase binding [GO:0043274]; phosphoprotein binding [GO:0051219]; protein homodimerization activity [GO:0042803]	astral microtubule [GO:0000235]; axon [GO:0030424]; cell cortex [GO:0005938]; cell leading edge [GO:0031252]; centrosome [GO:0005813]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; growth cone [GO:0030426]; kinesin complex [GO:0005871]; kinetochore [GO:0000776]; microtubule associated complex [GO:0005875]; motile primary cilium [GO:0031512]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; perinuclear region of cytoplasm [GO:0048471]	GO:0000086; GO:0001675; GO:0030036; GO:0008344; GO:0001667; GO:0000235; GO:0030424; GO:0048854; GO:0005938; GO:0031252; GO:0005813; GO:0021987; GO:0021895; GO:0021540; GO:0005829; GO:0034452; GO:0045502; GO:0051660; GO:0000132; GO:0070062; GO:0030426; GO:0008201; GO:0021766; GO:0005871; GO:0000776; GO:0021819; GO:0007611; GO:0016042; GO:0005875; GO:0008017; GO:0000226; GO:0031023; GO:0007017; GO:0000278; GO:0007067; GO:0031512; GO:0046329; GO:0010977; GO:0007405; GO:0050885; GO:0001764; GO:0043025; GO:0005635; GO:0051081; GO:0031965; GO:0007097; GO:0006996; GO:0036035; GO:0048471; GO:0043274; GO:0051219; GO:0046469; GO:0045773; GO:0001961; GO:0045931; GO:0042803; GO:0009306; GO:0008090; GO:0007264; GO:0017145; GO:0007268; GO:0019226; GO:0047496	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle {ECO:0000255|HAMAP-Rule:MF_03141}. Nucleus membrane {ECO:0000255|HAMAP-Rule:MF_03141}. Note=Redistributes to axons during neuronal development. Also localizes to the microtubules of the manchette in elongating spermatids and to the meiotic spindle in spermatocytes (By similarity). Localizes to the plus end of microtubules and to the centrosome. May localize to the nuclear membrane. {ECO:0000250}.	Acetylation; Alternative splicing; Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Differentiation; Disease mutation; Lipid degradation; Lipid metabolism; Lissencephaly; Membrane; Microtubule; Mitosis; Neurogenesis; Nucleus; Reference proteome; Repeat; Transport; WD repeat	Alternative sequence (4); Chain (1); Coiled coil (1); Domain (1); Modified residue (1); Natural variant (7); Region (6); Repeat (7); Sequence caution (1); Sequence conflict (4)
MBD4_HUMAN	O95243	MBD4_HUMAN	reviewed	Methyl-CpG-binding domain protein 4 (EC 3.2.2.-) (Methyl-CpG-binding endonuclease 1) (Methyl-CpG-binding protein MBD4) (Mismatch-specific DNA N-glycosylase)	MBD4 MED1	Homo sapiens (Human)	580	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; endodeoxyribonuclease activity [GO:0004520]; pyrimidine-specific mismatch base pair DNA N-glycosylase activity [GO:0008263]; satellite DNA binding [GO:0003696]; base-excision repair [GO:0006284]; base-excision repair, AP site formation [GO:0006285]; depyrimidination [GO:0045008]; DNA repair [GO:0006281]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mitotic G2 DNA damage checkpoint [GO:0007095]; response to radiation [GO:0009314]	base-excision repair [GO:0006284]; base-excision repair, AP site formation [GO:0006285]; depyrimidination [GO:0045008]; DNA repair [GO:0006281]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; mitotic G2 DNA damage checkpoint [GO:0007095]; response to radiation [GO:0009314]	endodeoxyribonuclease activity [GO:0004520]; pyrimidine-specific mismatch base pair DNA N-glycosylase activity [GO:0008263]; satellite DNA binding [GO:0003696]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0006281; GO:0006284; GO:0006285; GO:0000785; GO:0005737; GO:0045008; GO:0004520; GO:0008630; GO:0007095; GO:0005654; GO:0005634; GO:0008263; GO:0009314; GO:0003696	SUBCELLULAR LOCATION: Nucleus.	3D-structure; Alternative splicing; Complete proteome; DNA damage; DNA repair; DNA-binding; Hydrolase; Nucleus; Polymorphism; Reference proteome	Active site (1); Alternative sequence (5); Beta strand (2); Chain (1); Domain (1); Helix (13); Natural variant (7); Sequence conflict (3); Turn (3)
SODC_HUMAN	P00441	SODC_HUMAN	reviewed	Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) (Superoxide dismutase 1) (hSod1)	SOD1	Homo sapiens (Human)	154	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; dense core granule [GO:0031045]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; peroxisome [GO:0005777]; protein complex [GO:0043234]; chaperone binding [GO:0051087]; copper ion binding [GO:0005507]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein phosphatase 2B binding [GO:0030346]; Rac GTPase binding [GO:0048365]; superoxide dismutase activity [GO:0004784]; zinc ion binding [GO:0008270]; activation of MAPK activity [GO:0000187]; anterograde axon cargo transport [GO:0008089]; auditory receptor cell stereocilium organization [GO:0060088]; blood coagulation [GO:0007596]; cell aging [GO:0007569]; cellular iron ion homeostasis [GO:0006879]; cellular response to ATP [GO:0071318]; cellular response to cadmium ion [GO:0071276]; cellular response to potassium ion [GO:0035865]; embryo implantation [GO:0007566]; glutathione metabolic process [GO:0006749]; heart contraction [GO:0060047]; hydrogen peroxide biosynthetic process [GO:0050665]; locomotory behavior [GO:0007626]; muscle cell cellular homeostasis [GO:0046716]; myeloid cell homeostasis [GO:0002262]; negative regulation of cholesterol biosynthetic process [GO:0045541]; negative regulation of neuron apoptotic process [GO:0043524]; neurofilament cytoskeleton organization [GO:0060052]; ovarian follicle development [GO:0001541]; peripheral nervous system myelin maintenance [GO:0032287]; placenta development [GO:0001890]; platelet activation [GO:0030168]; platelet degranulation [GO:0002576]; positive regulation of apoptotic process [GO:0043065]; positive regulation of catalytic activity [GO:0043085]; positive regulation of cytokine production [GO:0001819]; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902177]; positive regulation of superoxide anion generation [GO:0032930]; reactive oxygen species metabolic process [GO:0072593]; regulation of blood pressure [GO:0008217]; regulation of GTPase activity [GO:0043087]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of multicellular organism growth [GO:0040014]; regulation of organ growth [GO:0046620]; regulation of protein kinase activity [GO:0045859]; regulation of T cell differentiation in thymus [GO:0033081]; relaxation of vascular smooth muscle [GO:0060087]; removal of superoxide radicals [GO:0019430]; response to amphetamine [GO:0001975]; response to antibiotic [GO:0046677]; response to antipsychotic drug [GO:0097332]; response to axon injury [GO:0048678]; response to carbon monoxide [GO:0034465]; response to copper ion [GO:0046688]; response to drug [GO:0042493]; response to ethanol [GO:0045471]; response to heat [GO:0009408]; response to hydrogen peroxide [GO:0042542]; response to nutrient levels [GO:0031667]; response to organic substance [GO:0010033]; response to reactive oxygen species [GO:0000302]; response to superoxide [GO:0000303]; retina homeostasis [GO:0001895]; retrograde axon cargo transport [GO:0008090]; sensory perception of sound [GO:0007605]; spermatogenesis [GO:0007283]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801]; thymus development [GO:0048538]; transmission of nerve impulse [GO:0019226]	activation of MAPK activity [GO:0000187]; anterograde axon cargo transport [GO:0008089]; auditory receptor cell stereocilium organization [GO:0060088]; blood coagulation [GO:0007596]; cell aging [GO:0007569]; cellular iron ion homeostasis [GO:0006879]; cellular response to ATP [GO:0071318]; cellular response to cadmium ion [GO:0071276]; cellular response to potassium ion [GO:0035865]; embryo implantation [GO:0007566]; glutathione metabolic process [GO:0006749]; heart contraction [GO:0060047]; hydrogen peroxide biosynthetic process [GO:0050665]; locomotory behavior [GO:0007626]; muscle cell cellular homeostasis [GO:0046716]; myeloid cell homeostasis [GO:0002262]; negative regulation of cholesterol biosynthetic process [GO:0045541]; negative regulation of neuron apoptotic process [GO:0043524]; neurofilament cytoskeleton organization [GO:0060052]; ovarian follicle development [GO:0001541]; peripheral nervous system myelin maintenance [GO:0032287]; placenta development [GO:0001890]; platelet activation [GO:0030168]; platelet degranulation [GO:0002576]; positive regulation of apoptotic process [GO:0043065]; positive regulation of catalytic activity [GO:0043085]; positive regulation of cytokine production [GO:0001819]; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902177]; positive regulation of superoxide anion generation [GO:0032930]; reactive oxygen species metabolic process [GO:0072593]; regulation of blood pressure [GO:0008217]; regulation of GTPase activity [GO:0043087]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of multicellular organism growth [GO:0040014]; regulation of organ growth [GO:0046620]; regulation of protein kinase activity [GO:0045859]; regulation of T cell differentiation in thymus [GO:0033081]; relaxation of vascular smooth muscle [GO:0060087]; removal of superoxide radicals [GO:0019430]; response to amphetamine [GO:0001975]; response to antibiotic [GO:0046677]; response to antipsychotic drug [GO:0097332]; response to axon injury [GO:0048678]; response to carbon monoxide [GO:0034465]; response to copper ion [GO:0046688]; response to drug [GO:0042493]; response to ethanol [GO:0045471]; response to heat [GO:0009408]; response to hydrogen peroxide [GO:0042542]; response to nutrient levels [GO:0031667]; response to organic substance [GO:0010033]; response to reactive oxygen species [GO:0000302]; response to superoxide [GO:0000303]; retina homeostasis [GO:0001895]; retrograde axon cargo transport [GO:0008090]; sensory perception of sound [GO:0007605]; spermatogenesis [GO:0007283]; superoxide anion generation [GO:0042554]; superoxide metabolic process [GO:0006801]; thymus development [GO:0048538]; transmission of nerve impulse [GO:0019226]	chaperone binding [GO:0051087]; copper ion binding [GO:0005507]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein phosphatase 2B binding [GO:0030346]; Rac GTPase binding [GO:0048365]; superoxide dismutase activity [GO:0004784]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite cytoplasm [GO:0032839]; dense core granule [GO:0031045]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; peroxisome [GO:0005777]; protein complex [GO:0043234]	GO:0048365; GO:0000187; GO:0008089; GO:0060088; GO:0007596; GO:0007569; GO:0006879; GO:0071318; GO:0071276; GO:0035865; GO:0051087; GO:0005507; GO:0005737; GO:0031410; GO:0005829; GO:0032839; GO:0031045; GO:0007566; GO:0070062; GO:0031012; GO:0005576; GO:0005615; GO:0006749; GO:0060047; GO:0050665; GO:0042802; GO:0007626; GO:0005758; GO:0005759; GO:0005739; GO:0046716; GO:0002262; GO:0045541; GO:0043524; GO:0060052; GO:0043025; GO:0005654; GO:0005634; GO:0001541; GO:0032287; GO:0005777; GO:0001890; GO:0030168; GO:0002576; GO:0043065; GO:0043085; GO:0001819; GO:1902177; GO:0032930; GO:0043234; GO:0042803; GO:0030346; GO:0072593; GO:0043087; GO:0033081; GO:0008217; GO:0051881; GO:0040014; GO:0046620; GO:0045859; GO:0060087; GO:0019430; GO:0001975; GO:0046677; GO:0097332; GO:0048678; GO:0034465; GO:0046688; GO:0042493; GO:0045471; GO:0009408; GO:0042542; GO:0031667; GO:0010033; GO:0000302; GO:0000303; GO:0001895; GO:0008090; GO:0007605; GO:0007283; GO:0042554; GO:0004784; GO:0006801; GO:0048538; GO:0019226; GO:0008270	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic; the pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria.	3D-structure; Acetylation; Amyotrophic lateral sclerosis; Antioxidant; Complete proteome; Copper; Cytoplasm; Direct protein sequencing; Disease mutation; Disulfide bond; Lipoprotein; Metal-binding; Neurodegeneration; Nucleus; Oxidoreductase; Palmitate; Phosphoprotein; Reference proteome; Ubl conjugation; Zinc	Beta strand (19); Chain (1); Cross-link (1); Disulfide bond (1); Helix (5); Initiator methionine (1); Lipidation (1); Metal binding (8); Modified residue (10); Mutagenesis (15); Natural variant (80); Sequence conflict (2); Turn (1)
HDAC1_HUMAN	Q13547	HDAC1_HUMAN	reviewed	Histone deacetylase 1 (HD1) (EC 3.5.1.98)	HDAC1 RPD3L1	Homo sapiens (Human)	482	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone deacetylase complex [GO:0000118]; nuclear chromatin [GO:0000790]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; protein complex [GO:0043234]; Sin3 complex [GO:0016580]; activating transcription factor binding [GO:0033613]; core promoter binding [GO:0001047]; deacetylase activity [GO:0019213]; enzyme binding [GO:0019899]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; NAD-dependent histone deacetylase activity (H3-K14 specific) [GO:0032041]; NAD-dependent histone deacetylase activity (H3-K18 specific) [GO:0097372]; NAD-dependent histone deacetylase activity (H3-K9 specific) [GO:0046969]; NAD-dependent histone deacetylase activity (H4-K16 specific) [GO:0046970]; NF-kappaB binding [GO:0051059]; protein deacetylase activity [GO:0033558]; protein N-terminus binding [GO:0047485]; repressing transcription factor binding [GO:0070491]; RNA polymerase II repressing transcription factor binding [GO:0001103]; RNA polymerase II transcription corepressor activity [GO:0001106]; sequence-specific DNA binding transcription factor activity [GO:0003700]; transcription factor binding [GO:0008134]; transcription regulatory region DNA binding [GO:0044212]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; ATP-dependent chromatin remodeling [GO:0043044]; blood coagulation [GO:0007596]; chromatin modification [GO:0016568]; chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; embryonic digit morphogenesis [GO:0042733]; epidermal cell differentiation [GO:0009913]; eyelid development in camera-type eye [GO:0061029]; fungiform papilla formation [GO:0061198]; gene expression [GO:0010467]; hair follicle placode formation [GO:0060789]; histone deacetylation [GO:0016575]; histone H3 deacetylation [GO:0070932]; histone H4 deacetylation [GO:0070933]; mitotic cell cycle [GO:0000278]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell cycle [GO:0045786]; negative regulation of gene expression [GO:0010629]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; neurotrophin TRK receptor signaling pathway [GO:0048011]; Notch signaling pathway [GO:0007219]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of cell proliferation [GO:0008284]; positive regulation of receptor biosynthetic process [GO:0010870]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]; protein deacetylation [GO:0006476]; regulation of gene expression, epigenetic [GO:0040029]; transcription initiation from RNA polymerase II promoter [GO:0006367]; transcription, DNA-templated [GO:0006351]; transforming growth factor beta receptor signaling pathway [GO:0007179]; viral process [GO:0016032]	ATP-dependent chromatin remodeling [GO:0043044]; blood coagulation [GO:0007596]; chromatin modification [GO:0016568]; chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; circadian regulation of gene expression [GO:0032922]; embryonic digit morphogenesis [GO:0042733]; epidermal cell differentiation [GO:0009913]; eyelid development in camera-type eye [GO:0061029]; fungiform papilla formation [GO:0061198]; gene expression [GO:0010467]; hair follicle placode formation [GO:0060789]; histone deacetylation [GO:0016575]; histone H3 deacetylation [GO:0070932]; histone H4 deacetylation [GO:0070933]; mitotic cell cycle [GO:0000278]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell cycle [GO:0045786]; negative regulation of gene expression [GO:0010629]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; neurotrophin TRK receptor signaling pathway [GO:0048011]; Notch signaling pathway [GO:0007219]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of cell proliferation [GO:0008284]; positive regulation of receptor biosynthetic process [GO:0010870]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein deacetylation [GO:0006476]; regulation of gene expression, epigenetic [GO:0040029]; transcription, DNA-templated [GO:0006351]; transcription initiation from RNA polymerase II promoter [GO:0006367]; transforming growth factor beta receptor signaling pathway [GO:0007179]; viral process [GO:0016032]	activating transcription factor binding [GO:0033613]; core promoter binding [GO:0001047]; deacetylase activity [GO:0019213]; enzyme binding [GO:0019899]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; NAD-dependent histone deacetylase activity (H3-K14 specific) [GO:0032041]; NAD-dependent histone deacetylase activity (H3-K18 specific) [GO:0097372]; NAD-dependent histone deacetylase activity (H3-K9 specific) [GO:0046969]; NAD-dependent histone deacetylase activity (H4-K16 specific) [GO:0046970]; NF-kappaB binding [GO:0051059]; protein deacetylase activity [GO:0033558]; protein N-terminus binding [GO:0047485]; repressing transcription factor binding [GO:0070491]; RNA polymerase II repressing transcription factor binding [GO:0001103]; RNA polymerase II transcription corepressor activity [GO:0001106]; sequence-specific DNA binding transcription factor activity [GO:0003700]; transcription factor binding [GO:0008134]; transcription regulatory region DNA binding [GO:0044212]; transcription regulatory region sequence-specific DNA binding [GO:0000976]	chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; histone deacetylase complex [GO:0000118]; nuclear chromatin [GO:0000790]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; protein complex [GO:0043234]; Sin3 complex [GO:0016580]	GO:0043044; GO:0032041; GO:0097372; GO:0046969; GO:0046970; GO:0051059; GO:0007219; GO:0016581; GO:0001103; GO:0001106; GO:0016580; GO:0033613; GO:0007596; GO:0000785; GO:0016568; GO:0006325; GO:0006338; GO:0032922; GO:0001047; GO:0005737; GO:0005829; GO:0019213; GO:0042733; GO:0019899; GO:0009913; GO:0061029; GO:0061198; GO:0010467; GO:0060789; GO:0070932; GO:0070933; GO:0004407; GO:0042826; GO:0000118; GO:0016575; GO:0000278; GO:0043922; GO:0060766; GO:0043066; GO:0045786; GO:0010629; GO:0045814; GO:0000122; GO:0045892; GO:0048011; GO:0000790; GO:0005654; GO:0005634; GO:0042475; GO:0008284; GO:0010870; GO:0045944; GO:0045893; GO:0047485; GO:0043234; GO:0033558; GO:0006476; GO:0040029; GO:0070491; GO:0003700; GO:0008134; GO:0006367; GO:0044212; GO:0000976; GO:0006351; GO:0007179; GO:0016032	SUBCELLULAR LOCATION: Nucleus.	3D-structure; Acetylation; Biological rhythms; Chromatin regulator; Complete proteome; Host-virus interaction; Hydrolase; Isopeptide bond; Methylation; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation; Ubl conjugation	Active site (1); Beta strand (11); Chain (1); Cross-link (2); Helix (16); Modified residue (6); Mutagenesis (11); Region (1); Sequence conflict (1); Turn (6)
RUXF_HUMAN	P62306	RUXF_HUMAN	reviewed	Small nuclear ribonucleoprotein F (snRNP-F) (Sm protein F) (Sm-F) (SmF)	SNRPF PBSCF	Homo sapiens (Human)	86	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; pICln-Sm protein complex [GO:0034715]; small nuclear ribonucleoprotein complex [GO:0030532]; small nucleolar ribonucleoprotein complex [GO:0005732]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681]; U1 snRNP [GO:0005685]; U12-type spliceosomal complex [GO:0005689]; U4 snRNP [GO:0005687]; U7 snRNP [GO:0005683]; RNA binding [GO:0003723]; activation of mitophagy in response to mitochondrial depolarization [GO:0098779]; gene expression [GO:0010467]; histone mRNA metabolic process [GO:0008334]; mRNA 3'-end processing [GO:0031124]; mRNA splicing, via spliceosome [GO:0000398]; ncRNA metabolic process [GO:0034660]; RNA splicing [GO:0008380]; spliceosomal snRNP assembly [GO:0000387]; termination of RNA polymerase II transcription [GO:0006369]; transcription from RNA polymerase II promoter [GO:0006366]	activation of mitophagy in response to mitochondrial depolarization [GO:0098779]; gene expression [GO:0010467]; histone mRNA metabolic process [GO:0008334]; mRNA 3'-end processing [GO:0031124]; mRNA splicing, via spliceosome [GO:0000398]; ncRNA metabolic process [GO:0034660]; RNA splicing [GO:0008380]; spliceosomal snRNP assembly [GO:0000387]; termination of RNA polymerase II transcription [GO:0006369]; transcription from RNA polymerase II promoter [GO:0006366]	RNA binding [GO:0003723]	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; pICln-Sm protein complex [GO:0034715]; small nuclear ribonucleoprotein complex [GO:0030532]; small nucleolar ribonucleoprotein complex [GO:0005732]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]; U1 snRNP [GO:0005685]; U4 snRNP [GO:0005687]; U7 snRNP [GO:0005683]	GO:0003723; GO:0008380; GO:0034719; GO:0005685; GO:0005689; GO:0005687; GO:0005683; GO:0098779; GO:0071013; GO:0005829; GO:0010467; GO:0008334; GO:0031124; GO:0000398; GO:0034709; GO:0034660; GO:0005654; GO:0034715; GO:0030532; GO:0005732; GO:0005681; GO:0000387; GO:0006369; GO:0006366	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:18984161}. Nucleus {ECO:0000269|PubMed:18984161}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; RNA-binding; Reference proteome; Ribonucleoprotein; Spliceosome; mRNA processing; mRNA splicing	Beta strand (5); Chain (1); Helix (2); Initiator methionine (1); Modified residue (1); Sequence conflict (1)
NCBP1_HUMAN	Q09161	NCBP1_HUMAN	reviewed	Nuclear cap-binding protein subunit 1 (80 kDa nuclear cap-binding protein) (CBP80) (NCBP 80 kDa subunit)	NCBP1 CBP80 NCBP	Homo sapiens (Human)	790	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; mRNA cap binding complex [GO:0005845]; nuclear cap binding complex [GO:0005846]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339]; 7-methylguanosine mRNA capping [GO:0006370]; gene expression [GO:0010467]; gene silencing by RNA [GO:0031047]; histone mRNA metabolic process [GO:0008334]; mRNA 3'-end processing [GO:0031124]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA cleavage [GO:0006379]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; ncRNA metabolic process [GO:0034660]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of mRNA 3'-end processing [GO:0031442]; positive regulation of viral transcription [GO:0050434]; regulation of translational initiation [GO:0006446]; RNA splicing [GO:0008380]; spliceosomal snRNP assembly [GO:0000387]; termination of RNA polymerase II transcription [GO:0006369]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]; viral process [GO:0016032]	7-methylguanosine mRNA capping [GO:0006370]; gene expression [GO:0010467]; gene silencing by RNA [GO:0031047]; histone mRNA metabolic process [GO:0008334]; mRNA 3'-end processing [GO:0031124]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA cleavage [GO:0006379]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; ncRNA metabolic process [GO:0034660]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of mRNA 3'-end processing [GO:0031442]; positive regulation of viral transcription [GO:0050434]; regulation of translational initiation [GO:0006446]; RNA splicing [GO:0008380]; spliceosomal snRNP assembly [GO:0000387]; termination of RNA polymerase II transcription [GO:0006369]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]; viral process [GO:0016032]	poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; RNA cap binding [GO:0000339]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; mRNA cap binding complex [GO:0005845]; nuclear cap binding complex [GO:0005846]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]	GO:0006370; GO:0003723; GO:0000339; GO:0008380; GO:0005737; GO:0005829; GO:0010467; GO:0031047; GO:0008334; GO:0031124; GO:0005845; GO:0045292; GO:0006379; GO:0006406; GO:0000398; GO:0005739; GO:0034660; GO:0005846; GO:0000184; GO:0005654; GO:0005634; GO:0044822; GO:0031442; GO:0050434; GO:0006446; GO:0030529; GO:0000387; GO:0006369; GO:0006368; GO:0006366; GO:0016032	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.	3D-structure; Acetylation; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Nonsense-mediated mRNA decay; Nucleus; Phosphoprotein; RNA-mediated gene silencing; Reference proteome; Translation regulation; Transport; mRNA capping; mRNA processing; mRNA splicing; mRNA transport	Beta strand (7); Chain (1); Coiled coil (1); Domain (1); Erroneous gene model prediction (1); Erroneous initiation (1); Helix (44); Modified residue (5); Motif (1); Mutagenesis (3); Sequence conflict (3); Turn (7)
PSA5_HUMAN	P28066	PSA5_HUMAN	reviewed	Proteasome subunit alpha type-5 (EC 3.4.25.1) (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome zeta chain)	PSMA5	Homo sapiens (Human)	241	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]; endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298]; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]	GO:0006977; GO:0000082; GO:0031145; GO:0042590; GO:0002479; GO:0002474; GO:0006915; GO:0034641; GO:0005737; GO:0005829; GO:0004175; GO:0070062; GO:0010467; GO:0045087; GO:0000278; GO:0043066; GO:0090090; GO:0051436; GO:0005654; GO:0005634; GO:0090263; GO:0051437; GO:0012501; GO:0010499; GO:0000502; GO:0005839; GO:0019773; GO:0043161; GO:0000209; GO:0042981; GO:0006521; GO:0051439; GO:0044281; GO:0002223; GO:0004298; GO:0016032	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Glycoprotein; Hydrolase; Nucleus; Phosphoprotein; Protease; Proteasome; Reference proteome; Threonine protease	Alternative sequence (1); Beta strand (11); Chain (1); Glycosylation (1); Helix (7); Modified residue (4); Sequence conflict (2); Turn (2)
FKB1A_HUMAN	P62942	FKB1A_HUMAN	reviewed	Peptidyl-prolyl cis-trans isomerase FKBP1A (PPIase FKBP1A) (EC 5.2.1.8) (12 kDa FK506-binding protein) (12 kDa FKBP) (FKBP-12) (Calstabin-1) (FK506-binding protein 1A) (FKBP-1A) (Immunophilin FKBP12) (Rotamase)	FKBP1A FKBP1 FKBP12	Homo sapiens (Human)	108	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; membrane [GO:0016020]; terminal cisterna [GO:0014802]; Z disc [GO:0030018]; activin binding [GO:0048185]; FK506 binding [GO:0005528]; ion channel binding [GO:0044325]; macrolide binding [GO:0005527]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; signal transducer activity [GO:0004871]; SMAD binding [GO:0046332]; transforming growth factor beta receptor binding [GO:0005160]; type I transforming growth factor beta receptor binding [GO:0034713]; 'de novo' protein folding [GO:0006458]; amyloid fibril formation [GO:1990000]; calcium ion transmembrane transport [GO:0070588]; chaperone-mediated protein folding [GO:0061077]; extracellular fibril organization [GO:0043206]; heart morphogenesis [GO:0003007]; heart trabecula formation [GO:0060347]; negative regulation of protein phosphatase type 2B activity [GO:0032513]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of protein binding [GO:0032092]; positive regulation of protein ubiquitination [GO:0031398]; protein folding [GO:0006457]; protein maturation by protein folding [GO:0022417]; protein peptidyl-prolyl isomerization [GO:0000413]; protein refolding [GO:0042026]; regulation of activin receptor signaling pathway [GO:0032925]; regulation of amyloid precursor protein catabolic process [GO:1902991]; regulation of immune response [GO:0050776]; regulation of protein localization [GO:0032880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; SMAD protein complex assembly [GO:0007183]; T cell activation [GO:0042110]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]	'de novo' protein folding [GO:0006458]; amyloid fibril formation [GO:1990000]; calcium ion transmembrane transport [GO:0070588]; chaperone-mediated protein folding [GO:0061077]; extracellular fibril organization [GO:0043206]; heart morphogenesis [GO:0003007]; heart trabecula formation [GO:0060347]; negative regulation of protein phosphatase type 2B activity [GO:0032513]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of protein binding [GO:0032092]; positive regulation of protein ubiquitination [GO:0031398]; protein folding [GO:0006457]; protein maturation by protein folding [GO:0022417]; protein peptidyl-prolyl isomerization [GO:0000413]; protein refolding [GO:0042026]; regulation of activin receptor signaling pathway [GO:0032925]; regulation of amyloid precursor protein catabolic process [GO:1902991]; regulation of immune response [GO:0050776]; regulation of protein localization [GO:0032880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; SMAD protein complex assembly [GO:0007183]; T cell activation [GO:0042110]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]	activin binding [GO:0048185]; FK506 binding [GO:0005528]; ion channel binding [GO:0044325]; macrolide binding [GO:0005527]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; signal transducer activity [GO:0004871]; SMAD binding [GO:0046332]; transforming growth factor beta receptor binding [GO:0005160]; type I transforming growth factor beta receptor binding [GO:0034713]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; membrane [GO:0016020]; terminal cisterna [GO:0014802]; Z disc [GO:0030018]	GO:0006458; GO:0005528; GO:0046332; GO:0007183; GO:0042110; GO:0030018; GO:0048185; GO:1990000; GO:0070588; GO:0061077; GO:0005737; GO:0005829; GO:0005789; GO:0070062; GO:0043206; GO:0031012; GO:0003007; GO:0060347; GO:0044325; GO:0005527; GO:0016020; GO:0032513; GO:0003755; GO:0043123; GO:0032092; GO:0031398; GO:0006457; GO:0022417; GO:0000413; GO:0042026; GO:0032925; GO:1902991; GO:0050776; GO:0032880; GO:0060314; GO:0004871; GO:0014802; GO:0005160; GO:0007179; GO:0034713; GO:0055010	SUBCELLULAR LOCATION: Cytoplasm.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Isomerase; Reference proteome; Rotamase	Beta strand (6); Chain (1); Domain (1); Helix (3); Initiator methionine (1); Modified residue (2); Sequence conflict (2); Turn (3)
E9PPJ0_HUMAN	E9PPJ0	E9PPJ0_HUMAN	unreviewed	Splicing factor 3B subunit 2	SF3B2	Homo sapiens (Human)	878	nucleoplasm [GO:0005654]			nucleoplasm [GO:0005654]	GO:0005654		Complete proteome; Proteomics identification; Reference proteome	
ACLY_HUMAN	P53396	ACLY_HUMAN	reviewed	ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (ACL) (Citrate cleavage enzyme)	ACLY	Homo sapiens (Human)	1101	citrate lyase complex [GO:0009346]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATP citrate synthase activity [GO:0003878]; cofactor binding [GO:0048037]; metal ion binding [GO:0046872]; succinate-CoA ligase (ADP-forming) activity [GO:0004775]; cellular carbohydrate metabolic process [GO:0044262]; cellular lipid metabolic process [GO:0044255]; citrate metabolic process [GO:0006101]; coenzyme A metabolic process [GO:0015936]; energy reserve metabolic process [GO:0006112]; lipid biosynthetic process [GO:0008610]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; positive regulation of cellular metabolic process [GO:0031325]; small molecule metabolic process [GO:0044281]; triglyceride biosynthetic process [GO:0019432]	cellular carbohydrate metabolic process [GO:0044262]; cellular lipid metabolic process [GO:0044255]; citrate metabolic process [GO:0006101]; coenzyme A metabolic process [GO:0015936]; energy reserve metabolic process [GO:0006112]; lipid biosynthetic process [GO:0008610]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; positive regulation of cellular metabolic process [GO:0031325]; small molecule metabolic process [GO:0044281]; triglyceride biosynthetic process [GO:0019432]	ATP binding [GO:0005524]; ATP citrate synthase activity [GO:0003878]; cofactor binding [GO:0048037]; metal ion binding [GO:0046872]; succinate-CoA ligase (ADP-forming) activity [GO:0004775]	citrate lyase complex [GO:0009346]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	GO:0005524; GO:0003878; GO:0044262; GO:0044255; GO:0009346; GO:0006101; GO:0015936; GO:0048037; GO:0005737; GO:0005829; GO:0006112; GO:0070062; GO:0008610; GO:0035338; GO:0016020; GO:0046872; GO:0005739; GO:0005654; GO:0005886; GO:0031325; GO:0044281; GO:0004775; GO:0019432	SUBCELLULAR LOCATION: Cytoplasm.	3D-structure; ATP-binding; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Isopeptide bond; Lipid biosynthesis; Lipid metabolism; Magnesium; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Transferase; Ubl conjugation	Active site (1); Alternative sequence (2); Beta strand (34); Binding site (5); Chain (1); Cross-link (3); Domain (1); Helix (31); Metal binding (3); Modified residue (17); Mutagenesis (3); Natural variant (1); Nucleotide binding (4); Region (1); Sequence conflict (10); Turn (8)
PAF1_HUMAN	Q8N7H5	PAF1_HUMAN	reviewed	RNA polymerase II-associated factor 1 homolog (hPAF1) (Pancreatic differentiation protein 2)	PAF1 PD2	Homo sapiens (Human)	531	Cdc73/Paf1 complex [GO:0016593]; cytoplasm [GO:0005737]; membrane [GO:0016020]; chromatin binding [GO:0003682]; RNA polymerase II core binding [GO:0000993]; cellular response to lipopolysaccharide [GO:0071222]; endodermal cell fate commitment [GO:0001711]; histone H2B ubiquitination [GO:0033523]; histone monoubiquitination [GO:0010390]; mRNA polyadenylation [GO:0006378]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; nucleosome positioning [GO:0016584]; positive regulation of histone methylation [GO:0031062]; positive regulation of mRNA 3'-end processing [GO:0031442]; positive regulation of transcription elongation from RNA polymerase II promoter [GO:0032968]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein localization to nucleus [GO:0034504]; stem cell maintenance [GO:0019827]; transcription, DNA-templated [GO:0006351]; Wnt signaling pathway [GO:0016055]	cellular response to lipopolysaccharide [GO:0071222]; endodermal cell fate commitment [GO:0001711]; histone H2B ubiquitination [GO:0033523]; histone monoubiquitination [GO:0010390]; mRNA polyadenylation [GO:0006378]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; nucleosome positioning [GO:0016584]; positive regulation of histone methylation [GO:0031062]; positive regulation of mRNA 3'-end processing [GO:0031442]; positive regulation of transcription elongation from RNA polymerase II promoter [GO:0032968]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein localization to nucleus [GO:0034504]; stem cell maintenance [GO:0019827]; transcription, DNA-templated [GO:0006351]; Wnt signaling pathway [GO:0016055]	chromatin binding [GO:0003682]; RNA polymerase II core binding [GO:0000993]	Cdc73/Paf1 complex [GO:0016593]; cytoplasm [GO:0005737]; membrane [GO:0016020]	GO:0016593; GO:0000993; GO:0016055; GO:0071222; GO:0003682; GO:0005737; GO:0001711; GO:0033523; GO:0010390; GO:0006378; GO:0016020; GO:0045638; GO:0000122; GO:0016584; GO:0031062; GO:0031442; GO:0032968; GO:0045944; GO:0034504; GO:0019827; GO:0006351	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16491129}. Note=Punctuate distribution throughout the nucleus except in nucleoli and the perinuclear chromatin.	3D-structure; Alternative splicing; Coiled coil; Complete proteome; Nucleus; Reference proteome; Transcription; Transcription regulation; Tumor suppressor; Wnt signaling pathway	Alternative sequence (5); Beta strand (4); Chain (1); Coiled coil (1); Compositional bias (1); Erroneous gene model prediction (3); Helix (2); Sequence conflict (4)
HNRPF_HUMAN	P52597	HNRPF_HUMAN	reviewed	Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed]	HNRNPF HNRPF	Homo sapiens (Human)	415	catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]; gene expression [GO:0010467]; mRNA splicing, via spliceosome [GO:0000398]; regulation of RNA splicing [GO:0043484]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]	gene expression [GO:0010467]; mRNA splicing, via spliceosome [GO:0000398]; regulation of RNA splicing [GO:0043484]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]	nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]	catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003723; GO:0006396; GO:0008380; GO:0071013; GO:0010467; GO:0000398; GO:0016020; GO:0005654; GO:0000166; GO:0005634; GO:0044822; GO:0043484; GO:0003727	SUBCELLULAR LOCATION: Nucleus, nucleoplasm.	3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Isopeptide bond; Nucleus; Phosphoprotein; Polymorphism; RNA-binding; Reference proteome; Repeat; Ribonucleoprotein; Spliceosome; Ubl conjugation; mRNA processing; mRNA splicing	Beta strand (21); Chain (2); Cross-link (1); Domain (3); Helix (8); Initiator methionine (1); Modified residue (7); Mutagenesis (12); Natural variant (1); Region (3); Site (12); Turn (4)
MPPB_HUMAN	O75439	MPPB_HUMAN	reviewed	Mitochondrial-processing peptidase subunit beta (EC 3.4.24.64) (Beta-MPP) (P-52)	PMPCB MPPB	Homo sapiens (Human)	489	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; cellular protein metabolic process [GO:0044267]; protein targeting to mitochondrion [GO:0006626]	cellular protein metabolic process [GO:0044267]; protein targeting to mitochondrion [GO:0006626]	metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]	GO:0044267; GO:0046872; GO:0004222; GO:0005743; GO:0005759; GO:0006626	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}.	Complete proteome; Direct protein sequencing; Hydrolase; Metal-binding; Metalloprotease; Mitochondrion; Polymorphism; Protease; Reference proteome; Transit peptide; Zinc	Active site (1); Chain (1); Metal binding (3); Natural variant (1); Sequence conflict (1); Transit peptide (1)
EIF3M_HUMAN	Q7L2H7	EIF3M_HUMAN	reviewed	Eukaryotic translation initiation factor 3 subunit M (eIF3m) (Fetal lung protein B5) (hFL-B5) (PCI domain-containing protein 1)	EIF3M HFLB5 PCID1 GA17 PNAS-125	Homo sapiens (Human)	374	eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; translation initiation factor activity [GO:0003743]; cytoplasmic translational initiation [GO:0002183]; formation of translation preinitiation complex [GO:0001731]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413]	cytoplasmic translational initiation [GO:0002183]; formation of translation preinitiation complex [GO:0001731]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413]	translation initiation factor activity [GO:0003743]	eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]	GO:0002183; GO:0016282; GO:0033290; GO:0005852; GO:0071541; GO:0001731; GO:0006446; GO:0003743; GO:0006413	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03012}.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Initiation factor; Phosphoprotein; Polymorphism; Protein biosynthesis; Reference proteome	Alternative sequence (1); Chain (1); Domain (1); Erroneous initiation (1); Frameshift (1); Initiator methionine (1); Mass spectrometry (2); Modified residue (3); Mutagenesis (4); Natural variant (3); Region (1); Sequence conflict (7)
RL4_HUMAN	P36578	RL4_HUMAN	reviewed	60S ribosomal protein L4 (60S ribosomal protein L1)	RPL4 RPL1	Homo sapiens (Human)	427	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]	GO:0003723; GO:0006614; GO:0044267; GO:0005737; GO:0005829; GO:0022625; GO:0070062; GO:0005925; GO:0010467; GO:0016020; GO:0000184; GO:0005730; GO:0005634; GO:0044822; GO:0030529; GO:0003735; GO:0006412; GO:0006414; GO:0006413; GO:0006415; GO:0019058; GO:0016032; GO:0019083		3D-structure; Acetylation; Citrullination; Complete proteome; Direct protein sequencing; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein	Chain (1); Compositional bias (1); Initiator methionine (1); Modified residue (10); Sequence conflict (5)
RS15A_HUMAN	P62244	RS15A_HUMAN	reviewed	40S ribosomal protein S15a	RPS15A OK/SW-cl.82	Homo sapiens (Human)	130	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell proliferation [GO:0008284]; response to virus [GO:0009615]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell proliferation [GO:0008284]; response to virus [GO:0009615]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; membrane [GO:0016020]	GO:0003723; GO:0006614; GO:0044267; GO:0005737; GO:0005829; GO:0022627; GO:0070062; GO:0010467; GO:0016020; GO:0000184; GO:0044822; GO:0045787; GO:0008284; GO:0009615; GO:0003735; GO:0006412; GO:0006414; GO:0006413; GO:0006415; GO:0019058; GO:0016032; GO:0019083		3D-structure; Complete proteome; Direct protein sequencing; Reference proteome; Ribonucleoprotein; Ribosomal protein	Chain (1); Frameshift (1); Initiator methionine (1); Modified residue (1); Sequence conflict (3)
PPIA_HUMAN	P62937	PPIA_HUMAN	reviewed	Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed]	PPIA CYPA	Homo sapiens (Human)	165	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; peptide binding [GO:0042277]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; poly(A) RNA binding [GO:0044822]; unfolded protein binding [GO:0051082]; virion binding [GO:0046790]; blood coagulation [GO:0007596]; entry into host cell [GO:0030260]; establishment of integrated proviral latency [GO:0075713]; leukocyte migration [GO:0050900]; lipid particle organization [GO:0034389]; platelet activation [GO:0030168]; platelet degranulation [GO:0002576]; positive regulation of protein secretion [GO:0050714]; positive regulation of viral genome replication [GO:0045070]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]; regulation of viral genome replication [GO:0045069]; RNA-dependent DNA replication [GO:0006278]; uncoating of virus [GO:0019061]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral release from host cell [GO:0019076]; virion assembly [GO:0019068]	blood coagulation [GO:0007596]; entry into host cell [GO:0030260]; establishment of integrated proviral latency [GO:0075713]; leukocyte migration [GO:0050900]; lipid particle organization [GO:0034389]; platelet activation [GO:0030168]; platelet degranulation [GO:0002576]; positive regulation of protein secretion [GO:0050714]; positive regulation of viral genome replication [GO:0045070]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]; regulation of viral genome replication [GO:0045069]; RNA-dependent DNA replication [GO:0006278]; uncoating of virus [GO:0019061]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral release from host cell [GO:0019076]; virion assembly [GO:0019068]	peptide binding [GO:0042277]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; poly(A) RNA binding [GO:0044822]; unfolded protein binding [GO:0051082]; virion binding [GO:0046790]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]	GO:0006278; GO:0007596; GO:0005829; GO:0030260; GO:0075713; GO:0070062; GO:0005576; GO:0005615; GO:0005925; GO:0050900; GO:0034389; GO:0016020; GO:0005634; GO:0042277; GO:0003755; GO:0030168; GO:0002576; GO:0044822; GO:0050714; GO:0045070; GO:0006457; GO:0000413; GO:0045069; GO:0019061; GO:0051082; GO:0019058; GO:0016032; GO:0019076; GO:0019068; GO:0046790	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16527992}. Secreted {ECO:0000269|PubMed:16527992}. Note=Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that involves actin remodeling and myosin II activation, and mediates ERK1/2 activation.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cyclosporin; Cytoplasm; Direct protein sequencing; Glycoprotein; Host-virus interaction; Isomerase; Isopeptide bond; Phosphoprotein; Reference proteome; Rotamase; Secreted; Ubl conjugation	Alternative sequence (1); Beta strand (12); Chain (2); Cross-link (1); Domain (1); Glycosylation (1); Helix (4); Initiator methionine (1); Modified residue (10); Mutagenesis (2); Sequence conflict (3); Turn (6)
AL9A1_HUMAN	P49189	AL9A1_HUMAN	reviewed	4-trimethylaminobutyraldehyde dehydrogenase (TMABADH) (EC 1.2.1.47) (Aldehyde dehydrogenase E3 isozyme) (Aldehyde dehydrogenase family 9 member A1) (EC 1.2.1.3) (Gamma-aminobutyraldehyde dehydrogenase) (EC 1.2.1.19) (R-aminobutyraldehyde dehydrogenase)	ALDH9A1 ALDH4 ALDH7 ALDH9	Homo sapiens (Human)	494	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; 1-pyrroline dehydrogenase activity [GO:0033737]; 3-chloroallyl aldehyde dehydrogenase activity [GO:0004028]; 4-trimethylammoniobutyraldehyde dehydrogenase activity [GO:0047105]; aldehyde dehydrogenase (NAD) activity [GO:0004029]; amine binding [GO:0043176]; aminobutyraldehyde dehydrogenase activity [GO:0019145]; NAD binding [GO:0051287]; carnitine biosynthetic process [GO:0045329]; cellular aldehyde metabolic process [GO:0006081]; cellular nitrogen compound metabolic process [GO:0034641]; hormone metabolic process [GO:0042445]; kidney development [GO:0001822]; liver development [GO:0001889]; neurotransmitter biosynthetic process [GO:0042136]; oxidation-reduction process [GO:0055114]; small molecule metabolic process [GO:0044281]	carnitine biosynthetic process [GO:0045329]; cellular aldehyde metabolic process [GO:0006081]; cellular nitrogen compound metabolic process [GO:0034641]; hormone metabolic process [GO:0042445]; kidney development [GO:0001822]; liver development [GO:0001889]; neurotransmitter biosynthetic process [GO:0042136]; oxidation-reduction process [GO:0055114]; small molecule metabolic process [GO:0044281]	1-pyrroline dehydrogenase activity [GO:0033737]; 3-chloroallyl aldehyde dehydrogenase activity [GO:0004028]; 4-trimethylammoniobutyraldehyde dehydrogenase activity [GO:0047105]; aldehyde dehydrogenase (NAD) activity [GO:0004029]; amine binding [GO:0043176]; aminobutyraldehyde dehydrogenase activity [GO:0019145]; NAD binding [GO:0051287]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]	GO:0033737; GO:0004028; GO:0047105; GO:0051287; GO:0004029; GO:0043176; GO:0019145; GO:0045329; GO:0006081; GO:0034641; GO:0005737; GO:0005829; GO:0070062; GO:0042445; GO:0001822; GO:0001889; GO:0005739; GO:0042136; GO:0055114; GO:0044281	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.	Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; NAD; Oxidoreductase; Polymorphism; Reference proteome	Active site (2); Alternative sequence (1); Chain (1); Erroneous initiation (1); Initiator methionine (1); Modified residue (8); Natural variant (1); Nucleotide binding (1); Sequence conflict (4); Site (1)
SKP1_HUMAN	P63208	SKP1_HUMAN	reviewed	S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (p19A) (Organ of Corti protein 2) (OCP-2) (Organ of Corti protein II) (OCP-II) (RNA polymerase II elongation factor-like protein) (SIII) (Transcription elongation factor B polypeptide 1-like) (p19skp1)	SKP1 EMC19 OCP2 SKP1A TCEB1L	Homo sapiens (Human)	163	Cul7-RING ubiquitin ligase complex [GO:0031467]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin-protein transferase activity [GO:0004842]; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; circadian rhythm [GO:0007623]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; histone H2A monoubiquitination [GO:0035518]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; Notch signaling pathway [GO:0007219]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; protein ubiquitination [GO:0016567]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; circadian rhythm [GO:0007623]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; histone H2A monoubiquitination [GO:0035518]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; Notch signaling pathway [GO:0007219]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; protein ubiquitination [GO:0016567]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	ubiquitin-protein transferase activity [GO:0004842]	Cul7-RING ubiquitin ligase complex [GO:0031467]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; SCF ubiquitin ligase complex [GO:0019005]	GO:0031467; GO:0000082; GO:0000086; GO:0007219; GO:0019005; GO:0031146; GO:0031145; GO:0007623; GO:0005829; GO:0070062; GO:0035518; GO:0045087; GO:0000278; GO:0005654; GO:0051437; GO:0016567; GO:0051439; GO:0002223; GO:0004842; GO:0016032		3D-structure; Alternative splicing; Complete proteome; Direct protein sequencing; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation pathway	Alternative sequence (1); Beta strand (6); Chain (1); Helix (8); Initiator methionine (1); Modified residue (1); Natural variant (1); Region (1); Turn (1)
ERAP1_HUMAN	Q9NZ08	ERAP1_HUMAN	reviewed	Endoplasmic reticulum aminopeptidase 1 (EC 3.4.11.-) (ARTS-1) (Adipocyte-derived leucine aminopeptidase) (A-LAP) (Aminopeptidase PILS) (Puromycin-insensitive leucyl-specific aminopeptidase) (PILS-AP) (Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator)	ERAP1 APPILS ARTS1 KIAA0525 UNQ584/PRO1154	Homo sapiens (Human)	941	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; aminopeptidase activity [GO:0004177]; interleukin-1, Type II receptor binding [GO:0005151]; interleukin-6 receptor binding [GO:0005138]; metalloexopeptidase activity [GO:0008235]; zinc ion binding [GO:0008270]; angiogenesis [GO:0001525]; antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; fat cell differentiation [GO:0045444]; membrane protein ectodomain proteolysis [GO:0006509]; positive regulation of angiogenesis [GO:0045766]; regulation of blood pressure [GO:0008217]; regulation of innate immune response [GO:0045088]; response to bacterium [GO:0009617]	angiogenesis [GO:0001525]; antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; fat cell differentiation [GO:0045444]; membrane protein ectodomain proteolysis [GO:0006509]; positive regulation of angiogenesis [GO:0045766]; regulation of blood pressure [GO:0008217]; regulation of innate immune response [GO:0045088]; response to bacterium [GO:0009617]	aminopeptidase activity [GO:0004177]; interleukin-1, Type II receptor binding [GO:0005151]; interleukin-6 receptor binding [GO:0005138]; metalloexopeptidase activity [GO:0008235]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; integral component of membrane [GO:0016021]; membrane [GO:0016020]	GO:0004177; GO:0001525; GO:0019885; GO:0002474; GO:0005829; GO:0005783; GO:0005788; GO:0005789; GO:0070062; GO:0005576; GO:0005615; GO:0045444; GO:0016021; GO:0005151; GO:0005138; GO:0016020; GO:0006509; GO:0008235; GO:0045766; GO:0008217; GO:0045088; GO:0009617; GO:0008270	SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:15908954}; Single-pass type II membrane protein {ECO:0000305|PubMed:15908954}.	3D-structure; Adaptive immunity; Alternative splicing; Aminopeptidase; Complete proteome; Direct protein sequencing; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Hydrolase; Immunity; Membrane; Metal-binding; Metalloprotease; Polymorphism; Protease; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix; Zinc	Active site (1); Alternative sequence (1); Beta strand (31); Binding site (1); Chain (1); Disulfide bond (2); Erroneous initiation (1); Glycosylation (5); Helix (36); Metal binding (3); Mutagenesis (1); Natural variant (10); Region (1); Sequence conflict (4); Site (1); Topological domain (2); Transmembrane (1); Turn (12)
RMD5A_HUMAN	Q9H871	RMD5A_HUMAN	reviewed	Protein RMD5 homolog A	RMND5A	Homo sapiens (Human)	391							Acetylation; Alternative splicing; Complete proteome; Reference proteome	Alternative sequence (2); Chain (1); Domain (2); Modified residue (1); Sequence conflict (2)
ATPA_HUMAN	P25705	ATPA_HUMAN	reviewed	ATP synthase subunit alpha, mitochondrial	ATP5A1 ATP5A ATP5AL2 ATPM	Homo sapiens (Human)	553	extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; proton-transporting ATP synthase complex, catalytic core F(1) [GO:0045261]; ATP binding [GO:0005524]; MHC class I protein binding [GO:0042288]; poly(A) RNA binding [GO:0044822]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; transmembrane transporter activity [GO:0022857]; ATP biosynthetic process [GO:0006754]; ATP hydrolysis coupled proton transport [GO:0015991]; cellular metabolic process [GO:0044237]; embryo development [GO:0009790]; lipid metabolic process [GO:0006629]; mitochondrial ATP synthesis coupled proton transport [GO:0042776]; negative regulation of endothelial cell proliferation [GO:0001937]; respiratory electron transport chain [GO:0022904]; small molecule metabolic process [GO:0044281]	ATP biosynthetic process [GO:0006754]; ATP hydrolysis coupled proton transport [GO:0015991]; cellular metabolic process [GO:0044237]; embryo development [GO:0009790]; lipid metabolic process [GO:0006629]; mitochondrial ATP synthesis coupled proton transport [GO:0042776]; negative regulation of endothelial cell proliferation [GO:0001937]; respiratory electron transport chain [GO:0022904]; small molecule metabolic process [GO:0044281]	ATP binding [GO:0005524]; MHC class I protein binding [GO:0042288]; poly(A) RNA binding [GO:0044822]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; transmembrane transporter activity [GO:0022857]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; proton-transporting ATP synthase complex, catalytic core F(1) [GO:0045261]	GO:0005524; GO:0006754; GO:0015991; GO:0042288; GO:0044237; GO:0009790; GO:0070062; GO:0006629; GO:0016020; GO:0042776; GO:0005743; GO:0005759; GO:0005753; GO:0005739; GO:0001937; GO:0005886; GO:0044822; GO:0046933; GO:0045261; GO:0046961; GO:0022904; GO:0044281; GO:0022857	SUBCELLULAR LOCATION: Mitochondrion inner membrane. Cell membrane; Peripheral membrane protein; Extracellular side. Note=Colocalizes with HRG on the cell surface of T-cells.	ATP synthesis; ATP-binding; Acetylation; Alternative splicing; CF(1); Cell membrane; Complete proteome; Direct protein sequencing; Disease mutation; Glycoprotein; Hydrogen ion transport; Ion transport; Membrane; Mitochondrion; Mitochondrion inner membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Pyrrolidone carboxylic acid; Reference proteome; Transit peptide; Transport	Alternative sequence (2); Chain (1); Glycosylation (1); Modified residue (31); Natural variant (4); Nucleotide binding (1); Sequence conflict (6); Site (1); Transit peptide (1)
G3V5Z7_HUMAN	G3V5Z7	G3V5Z7_HUMAN	unreviewed	Proteasome subunit alpha type (EC 3.4.25.1)	PSMA6	Homo sapiens (Human)	252	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]; endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]	endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]	GO:0005737; GO:0004175; GO:0005654; GO:0005634; GO:0010499; GO:0005839; GO:0019773; GO:0043161; GO:0004298	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU000551}. Nucleus {ECO:0000256|RuleBase:RU000551}.	Complete proteome; Cytoplasm; Hydrolase; Nucleus; Protease; Proteasome; Proteomics identification; Reference proteome; Threonine protease	
PSA6_HUMAN	P60900	PSA6_HUMAN	reviewed	Proteasome subunit alpha type-6 (EC 3.4.25.1) (27 kDa prosomal protein) (PROS-27) (p27K) (Macropain iota chain) (Multicatalytic endopeptidase complex iota chain) (Proteasome iota chain)	PSMA6 PROS27	Homo sapiens (Human)	246	cytoplasm [GO:0005737]; cytoplasmic mRNA processing body [GO:0000932]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; myofibril [GO:0030016]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; polysome [GO:0005844]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]; sarcomere [GO:0030017]; endopeptidase activity [GO:0004175]; NF-kappaB binding [GO:0051059]; purine ribonucleoside triphosphate binding [GO:0035639]; RNA binding [GO:0003723]; threonine-type endopeptidase activity [GO:0004298]; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; proteolysis involved in cellular protein catabolic process [GO:0051603]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of inflammatory response [GO:0050727]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; proteolysis involved in cellular protein catabolic process [GO:0051603]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of inflammatory response [GO:0050727]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	endopeptidase activity [GO:0004175]; NF-kappaB binding [GO:0051059]; purine ribonucleoside triphosphate binding [GO:0035639]; RNA binding [GO:0003723]; threonine-type endopeptidase activity [GO:0004298]	cytoplasm [GO:0005737]; cytoplasmic mRNA processing body [GO:0000932]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; myofibril [GO:0030016]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; polysome [GO:0005844]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]; sarcomere [GO:0030017]	GO:0006977; GO:0000082; GO:0051059; GO:0003723; GO:0031145; GO:0042590; GO:0002479; GO:0002474; GO:0006915; GO:0034641; GO:0005737; GO:0000932; GO:0005829; GO:0004175; GO:0070062; GO:0010467; GO:0045087; GO:0000278; GO:0030016; GO:0043066; GO:0090090; GO:0051436; GO:0016363; GO:0005654; GO:0005634; GO:0005844; GO:0051092; GO:0090263; GO:0051437; GO:0012501; GO:0010499; GO:0000502; GO:0005839; GO:0019773; GO:0043161; GO:0000209; GO:0051603; GO:0035639; GO:0042981; GO:0006521; GO:0050727; GO:0051439; GO:0030017; GO:0044281; GO:0002223; GO:0004298; GO:0016032	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, P-body {ECO:0000250}. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250}.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Glycoprotein; Hydrolase; Isopeptide bond; Nucleus; Phosphoprotein; Polymorphism; Protease; Proteasome; Reference proteome; Threonine protease; Ubl conjugation	Alternative sequence (2); Beta strand (11); Chain (1); Cross-link (1); Glycosylation (1); Helix (7); Modified residue (3); Natural variant (1); Sequence conflict (1); Turn (1)
Q5T123_HUMAN	Q5T123	Q5T123_HUMAN	unreviewed	SH3 domain-binding glutamic acid-rich-like protein 3	SH3BGRL3	Homo sapiens (Human)	88							Complete proteome; Proteomics identification; Reference proteome	
SH3L3_HUMAN	Q9H299	SH3L3_HUMAN	reviewed	SH3 domain-binding glutamic acid-rich-like protein 3 (SH3 domain-binding protein 1) (SH3BP-1)	SH3BGRL3 P1725	Homo sapiens (Human)	93	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; electron carrier activity [GO:0009055]; GTPase activator activity [GO:0005096]; protein disulfide oxidoreductase activity [GO:0015035]; semaphorin receptor binding [GO:0030215]; cell redox homeostasis [GO:0045454]; positive regulation of GTPase activity [GO:0043547]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of actin filament depolymerization [GO:0030834]; regulation of blood vessel endothelial cell migration [GO:0043535]	cell redox homeostasis [GO:0045454]; positive regulation of GTPase activity [GO:0043547]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of actin filament depolymerization [GO:0030834]; regulation of blood vessel endothelial cell migration [GO:0043535]	electron carrier activity [GO:0009055]; GTPase activator activity [GO:0005096]; protein disulfide oxidoreductase activity [GO:0015035]; semaphorin receptor binding [GO:0030215]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; lamellipodium [GO:0030027]; nucleus [GO:0005634]	GO:0005096; GO:0045454; GO:0005737; GO:0009055; GO:0070062; GO:0030027; GO:0005634; GO:0043547; GO:0015035; GO:0032956; GO:0030834; GO:0043535; GO:0030215	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Nucleus; Reference proteome	Beta strand (4); Chain (1); Domain (1); Helix (4); Initiator methionine (1); Modified residue (1); Turn (1)
RS7_HUMAN	P62081	RS7_HUMAN	reviewed	40S ribosomal protein S7	RPS7	Homo sapiens (Human)	194	90S preribosome [GO:0030686]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]; ribosome [GO:0005840]; small-subunit processome [GO:0032040]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	90S preribosome [GO:0030686]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]; ribosome [GO:0005840]; small-subunit processome [GO:0032040]	GO:0030686; GO:0003723; GO:0006614; GO:0044267; GO:0005737; GO:0005829; GO:0022627; GO:0070062; GO:0005925; GO:0010467; GO:0016020; GO:0005815; GO:0000184; GO:0005730; GO:0005634; GO:0044822; GO:0006364; GO:0030529; GO:0042274; GO:0005840; GO:0032040; GO:0003735; GO:0006412; GO:0006414; GO:0006413; GO:0006415; GO:0019058; GO:0016032; GO:0019083	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20873783}. Note=Colocalizes with NEK6 in the centrosome.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Cytoskeleton; Diamond-Blackfan anemia; Direct protein sequencing; Reference proteome; Ribonucleoprotein; Ribosomal protein	Chain (1); Compositional bias (1); Modified residue (2)
DDX47_HUMAN	Q9H0S4	DDX47_HUMAN	reviewed	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.4.13) (DEAD box protein 47)	DDX47	Homo sapiens (Human)	455	membrane [GO:0016020]; nucleolus [GO:0005730]; ATP binding [GO:0005524]; ATP-dependent RNA helicase activity [GO:0004004]; poly(A) RNA binding [GO:0044822]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; mRNA processing [GO:0006397]; RNA secondary structure unwinding [GO:0010501]; RNA splicing [GO:0008380]; rRNA processing [GO:0006364]	extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; mRNA processing [GO:0006397]; RNA secondary structure unwinding [GO:0010501]; RNA splicing [GO:0008380]; rRNA processing [GO:0006364]	ATP binding [GO:0005524]; ATP-dependent RNA helicase activity [GO:0004004]; poly(A) RNA binding [GO:0044822]	membrane [GO:0016020]; nucleolus [GO:0005730]	GO:0005524; GO:0004004; GO:0010501; GO:0008380; GO:0008625; GO:0006397; GO:0016020; GO:0005730; GO:0044822; GO:0006364	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:16963496}. Note=Localizes in the nucleolar-organizing region during ribosome biogenesis.	3D-structure; ATP-binding; Acetylation; Alternative splicing; Apoptosis; Complete proteome; Direct protein sequencing; Helicase; Hydrolase; Nucleotide-binding; Nucleus; Phosphoprotein; RNA-binding; Reference proteome; mRNA processing; mRNA splicing; rRNA processing	Alternative sequence (1); Beta strand (7); Chain (1); Domain (2); Erroneous initiation (1); Helix (12); Initiator methionine (1); Modified residue (3); Motif (2); Nucleotide binding (1); Sequence conflict (1)
TALDO_HUMAN	P37837	TALDO_HUMAN	reviewed	Transaldolase (EC 2.2.1.2)	TALDO1 TAL TALDO TALDOR	Homo sapiens (Human)	337	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity [GO:0004801]; carbohydrate metabolic process [GO:0005975]; energy reserve metabolic process [GO:0006112]; pentose-phosphate shunt [GO:0006098]; small molecule metabolic process [GO:0044281]; xylulose biosynthetic process [GO:0005999]	carbohydrate metabolic process [GO:0005975]; energy reserve metabolic process [GO:0006112]; pentose-phosphate shunt [GO:0006098]; small molecule metabolic process [GO:0044281]; xylulose biosynthetic process [GO:0005999]	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity [GO:0004801]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	GO:0005975; GO:0005737; GO:0005829; GO:0006112; GO:0070062; GO:0005634; GO:0006098; GO:0004801; GO:0044281; GO:0005999	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Disease mutation; Pentose shunt; Phosphoprotein; Reference proteome; Schiff base; Transferase	Active site (1); Beta strand (8); Chain (1); Helix (19); Modified residue (6); Natural variant (1); Turn (2)
FAAA_HUMAN	P16930	FAAA_HUMAN	reviewed	Fumarylacetoacetase (FAA) (EC 3.7.1.2) (Beta-diketonase) (Fumarylacetoacetate hydrolase)	FAH	Homo sapiens (Human)	419	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; fumarylacetoacetase activity [GO:0004334]; metal ion binding [GO:0046872]; arginine catabolic process [GO:0006527]; cellular nitrogen compound metabolic process [GO:0034641]; L-phenylalanine catabolic process [GO:0006559]; small molecule metabolic process [GO:0044281]; tyrosine catabolic process [GO:0006572]	arginine catabolic process [GO:0006527]; cellular nitrogen compound metabolic process [GO:0034641]; L-phenylalanine catabolic process [GO:0006559]; small molecule metabolic process [GO:0044281]; tyrosine catabolic process [GO:0006572]	fumarylacetoacetase activity [GO:0004334]; metal ion binding [GO:0046872]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0006559; GO:0006527; GO:0034641; GO:0005829; GO:0070062; GO:0004334; GO:0046872; GO:0044281; GO:0006572		Acetylation; Alternative splicing; Calcium; Complete proteome; Direct protein sequencing; Disease mutation; Hydrolase; Magnesium; Metal-binding; Phenylalanine catabolism; Phosphoprotein; Reference proteome; Tyrosine catabolism	Active site (1); Alternative sequence (1); Binding site (5); Chain (1); Initiator methionine (1); Metal binding (7); Modified residue (3); Natural variant (22)
CH10_HUMAN	P61604	CH10_HUMAN	reviewed	10 kDa heat shock protein, mitochondrial (Hsp10) (10 kDa chaperonin) (Chaperonin 10) (CPN10) (Early-pregnancy factor) (EPF)	HSPE1	Homo sapiens (Human)	102	extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; chaperone binding [GO:0051087]; poly(A) RNA binding [GO:0044822]; unfolded protein binding [GO:0051082]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; osteoblast differentiation [GO:0001649]; protein folding [GO:0006457]; response to unfolded protein [GO:0006986]	activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; osteoblast differentiation [GO:0001649]; protein folding [GO:0006457]; response to unfolded protein [GO:0006986]	ATP binding [GO:0005524]; chaperone binding [GO:0051087]; poly(A) RNA binding [GO:0044822]; unfolded protein binding [GO:0051082]	extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0005524; GO:0006919; GO:0051087; GO:0070062; GO:0016020; GO:0005759; GO:0005739; GO:0001649; GO:0044822; GO:0006457; GO:0006986; GO:0051082	SUBCELLULAR LOCATION: Mitochondrion matrix.	3D-structure; Acetylation; Chaperone; Complete proteome; Direct protein sequencing; Mitochondrion; Phosphoprotein; Reference proteome; Stress response	Chain (1); Initiator methionine (1); Mass spectrometry (1); Modified residue (21)
OGFD1_HUMAN	Q8N543	OGFD1_HUMAN	reviewed	Prolyl 3-hydroxylase OGFOD1 (EC 1.14.11.-) (2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1) (Termination and polyadenylation 1 homolog)	OGFOD1 KIAA1612 TPA1	Homo sapiens (Human)	542	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nucleus [GO:0005634]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; peptidyl-proline 3-dioxygenase activity [GO:0031544]; peptidyl-proline dioxygenase activity [GO:0031543]; cell proliferation [GO:0008283]; peptidyl-proline hydroxylation [GO:0019511]; protein hydroxylation [GO:0018126]; regulation of translational termination [GO:0006449]; stress granule assembly [GO:0034063]	cell proliferation [GO:0008283]; peptidyl-proline hydroxylation [GO:0019511]; protein hydroxylation [GO:0018126]; regulation of translational termination [GO:0006449]; stress granule assembly [GO:0034063]	iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; peptidyl-proline 3-dioxygenase activity [GO:0031544]; peptidyl-proline dioxygenase activity [GO:0031543]	cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; nucleus [GO:0005634]	GO:0031418; GO:0008283; GO:0005737; GO:0010494; GO:0005506; GO:0005634; GO:0031544; GO:0031543; GO:0019511; GO:0018126; GO:0006449; GO:0034063	SUBCELLULAR LOCATION: Isoform 1: Cytoplasm. Nucleus. Note=Mainly nuclear. A portion relocalizes to cytoplasmic stress granules upon stress.; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm.	3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Dioxygenase; Iron; Metal-binding; Nucleus; Oxidoreductase; Polymorphism; Reference proteome; Vitamin C	Alternative sequence (1); Beta strand (22); Binding site (1); Chain (1); Domain (1); Erroneous initiation (2); Helix (16); Metal binding (3); Motif (1); Mutagenesis (2); Natural variant (1); Sequence conflict (3); Turn (1)
APEX1_HUMAN	P27695	APEX1_HUMAN	reviewed	DNA-(apurinic or apyrimidinic site) lyase (EC 3.1.-.-) (EC 4.2.99.18) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (APE-1) (REF-1) (Redox factor-1) [Cleaved into: DNA-(apurinic or apyrimidinic site) lyase, mitochondrial]	APEX1 APE APE1 APEX APX HAP1 REF1	Homo sapiens (Human)	318	centrosome [GO:0005813]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ribosome [GO:0005840]; transcription factor complex [GO:0005667]; 3'-5' exonuclease activity [GO:0008408]; chromatin DNA binding [GO:0031490]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA-(apurinic or apyrimidinic site) lyase activity [GO:0003906]; double-stranded DNA 3'-5' exodeoxyribonuclease activity [GO:0008311]; endodeoxyribonuclease activity [GO:0004520]; endonuclease activity [GO:0004519]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; phosphodiesterase I activity [GO:0004528]; phosphoric diester hydrolase activity [GO:0008081]; poly(A) RNA binding [GO:0044822]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; site-specific endodeoxyribonuclease activity, specific for altered base [GO:0016890]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; uracil DNA N-glycosylase activity [GO:0004844]; aging [GO:0007568]; base-excision repair [GO:0006284]; cell redox homeostasis [GO:0045454]; cellular response to cAMP [GO:0071320]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to peptide hormone stimulus [GO:0071375]; DNA demethylation [GO:0080111]; DNA repair [GO:0006281]; DNA strand elongation involved in DNA replication [GO:0006271]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; mismatch repair [GO:0006298]; mitotic cell cycle [GO:0000278]; negative regulation of nucleic acid-templated transcription [GO:1903507]; negative regulation of smooth muscle cell migration [GO:0014912]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair, DNA gap filling [GO:0006297]; oxidation-reduction process [GO:0055114]; positive regulation of DNA repair [GO:0045739]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; regulation of mRNA stability [GO:0043488]; regulation of transcription, DNA-templated [GO:0006355]; response to drug [GO:0042493]; telomere maintenance [GO:0000723]; telomere maintenance via recombination [GO:0000722]; telomere maintenance via semi-conservative replication [GO:0032201]; transcription, DNA-templated [GO:0006351]; transcription-coupled nucleotide-excision repair [GO:0006283]	aging [GO:0007568]; base-excision repair [GO:0006284]; cell redox homeostasis [GO:0045454]; cellular response to cAMP [GO:0071320]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to peptide hormone stimulus [GO:0071375]; DNA demethylation [GO:0080111]; DNA repair [GO:0006281]; DNA strand elongation involved in DNA replication [GO:0006271]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; mismatch repair [GO:0006298]; mitotic cell cycle [GO:0000278]; negative regulation of nucleic acid-templated transcription [GO:1903507]; negative regulation of smooth muscle cell migration [GO:0014912]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair, DNA gap filling [GO:0006297]; oxidation-reduction process [GO:0055114]; positive regulation of DNA repair [GO:0045739]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; regulation of mRNA stability [GO:0043488]; regulation of transcription, DNA-templated [GO:0006355]; response to drug [GO:0042493]; telomere maintenance [GO:0000723]; telomere maintenance via recombination [GO:0000722]; telomere maintenance via semi-conservative replication [GO:0032201]; transcription, DNA-templated [GO:0006351]; transcription-coupled nucleotide-excision repair [GO:0006283]	3'-5' exonuclease activity [GO:0008408]; chromatin DNA binding [GO:0031490]; damaged DNA binding [GO:0003684]; DNA-(apurinic or apyrimidinic site) lyase activity [GO:0003906]; DNA binding [GO:0003677]; double-stranded DNA 3'-5' exodeoxyribonuclease activity [GO:0008311]; endodeoxyribonuclease activity [GO:0004520]; endonuclease activity [GO:0004519]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; phosphodiesterase I activity [GO:0004528]; phosphoric diester hydrolase activity [GO:0008081]; poly(A) RNA binding [GO:0044822]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; site-specific endodeoxyribonuclease activity, specific for altered base [GO:0016890]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; uracil DNA N-glycosylase activity [GO:0004844]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ribosome [GO:0005840]; transcription factor complex [GO:0005667]	GO:0008408; GO:0003677; GO:0080111; GO:0006281; GO:0006271; GO:0003906; GO:0004523; GO:0007568; GO:0006284; GO:0045454; GO:0071320; GO:0070301; GO:0071375; GO:0005813; GO:0031490; GO:0005737; GO:0003684; GO:0006302; GO:0000724; GO:0008311; GO:0004520; GO:0004519; GO:0005783; GO:0046872; GO:0006298; GO:0005739; GO:0000278; GO:1903507; GO:0014912; GO:0016607; GO:0005730; GO:0005654; GO:0006289; GO:0006297; GO:0005634; GO:0055114; GO:0016491; GO:0048471; GO:0004528; GO:0008081; GO:0044822; GO:0045739; GO:1900087; GO:0043488; GO:0006355; GO:0042493; GO:0005840; GO:0016890; GO:0000723; GO:0000722; GO:0032201; GO:0003713; GO:0003714; GO:0005667; GO:0006351; GO:0006283; GO:0004844	SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus. Nucleus speckle. Endoplasmic reticulum. Cytoplasm. Note=Detected in the cytoplasm of B-cells stimulated to switch (By similarity). Colocalized with SIRT1 in the nucleus. Colocalized with YBX1 in nuclear speckles after genotoxic stress. Together with OGG1 is recruited to nuclear speckles in UVA-irradiated cells. Colocalized with nucleolin and NPM1 in the nucleolus. Its nucleolar localization is cell cycle dependent and requires active rRNA transcription. Colocalized with calreticulin in the endoplasmic reticulum. Translocation from the nucleus to the cytoplasm is stimulated in presence of nitric oxide (NO) and function in a CRM1-dependent manner, possibly as a consequence of demasking a nuclear export signal (amino acid position 64-80). S-nitrosylation at Cys-93 and Cys-310 regulates its nuclear-cytosolic shuttling. Ubiquitinated form is localized predominantly in the cytoplasm. {ECO:0000250}.; SUBCELLULAR LOCATION: DNA-(apurinic or apyrimidinic site) lyase, mitochondrial: Mitochondrion. Note=The cleaved APEX2 is only detected in mitochondria (By similarity). Translocation from the cytoplasm to the mitochondria is mediated by ROS signaling and cleavage mediated by granzyme A. Tom20-dependent translocated mitochondrial APEX1 level is significantly increased after genotoxic stress. {ECO:0000250}.	3D-structure; Acetylation; Activator; Cleavage on pair of basic residues; Complete proteome; Cytoplasm; DNA damage; DNA recombination; DNA repair; DNA-binding; Direct protein sequencing; Disulfide bond; Endonuclease; Endoplasmic reticulum; Exonuclease; Hydrolase; Lyase; Magnesium; Metal-binding; Mitochondrion; Nuclease; Nucleus; Phosphoprotein; Polymorphism; RNA-binding; Reference proteome; Repressor; S-nitrosylation; Transcription; Transcription regulation; Ubl conjugation	Active site (2); Beta strand (17); Chain (2); Disulfide bond (1); Helix (14); Initiator methionine (1); Metal binding (5); Modified residue (11); Motif (2); Mutagenesis (33); Natural variant (3); Region (3); Sequence conflict (2); Site (4); Turn (2)
SAHH_HUMAN	P23526	SAHH_HUMAN	reviewed	Adenosylhomocysteinase (AdoHcyase) (EC 3.3.1.1) (S-adenosyl-L-homocysteine hydrolase)	AHCY SAHH	Homo sapiens (Human)	432	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; adenosylhomocysteinase activity [GO:0004013]; cellular nitrogen compound metabolic process [GO:0034641]; methylation [GO:0032259]; one-carbon metabolic process [GO:0006730]; S-adenosylmethionine cycle [GO:0033353]; small molecule metabolic process [GO:0044281]; sulfur amino acid metabolic process [GO:0000096]; xenobiotic metabolic process [GO:0006805]	cellular nitrogen compound metabolic process [GO:0034641]; methylation [GO:0032259]; one-carbon metabolic process [GO:0006730]; S-adenosylmethionine cycle [GO:0033353]; small molecule metabolic process [GO:0044281]; sulfur amino acid metabolic process [GO:0000096]; xenobiotic metabolic process [GO:0006805]	adenosylhomocysteinase activity [GO:0004013]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]	GO:0033353; GO:0004013; GO:0034641; GO:0005737; GO:0005829; GO:0070062; GO:0042470; GO:0032259; GO:0006730; GO:0044281; GO:0000096; GO:0006805	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Hydrolase; NAD; One-carbon metabolism; Polymorphism; Reference proteome	Alternative sequence (1); Beta strand (20); Binding site (9); Chain (1); Helix (22); Initiator methionine (1); Modified residue (1); Natural variant (6); Nucleotide binding (3); Sequence conflict (1); Turn (4)
I3L2T8_HUMAN	I3L2T8	I3L2T8_HUMAN	unreviewed	Nuclear distribution protein nudE homolog 1 (Fragment)	NDE1	Homo sapiens (Human)	139	kinesin complex [GO:0005871]; microtubule binding [GO:0008017]; cell migration [GO:0016477]; centrosome localization [GO:0051642]; chromosome segregation [GO:0007059]; microtubule nucleation [GO:0007020]; mitotic centrosome separation [GO:0007100]; vesicle transport along microtubule [GO:0047496]	cell migration [GO:0016477]; centrosome localization [GO:0051642]; chromosome segregation [GO:0007059]; microtubule nucleation [GO:0007020]; mitotic centrosome separation [GO:0007100]; vesicle transport along microtubule [GO:0047496]	microtubule binding [GO:0008017]	kinesin complex [GO:0005871]	GO:0016477; GO:0051642; GO:0007059; GO:0005871; GO:0008017; GO:0007020; GO:0007100; GO:0047496		Complete proteome; Proteomics identification; Reference proteome	Non-terminal residue (1)
MCM6_HUMAN	Q14566	MCM6_HUMAN	reviewed	DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM)	MCM6	Homo sapiens (Human)	821	MCM complex [GO:0042555]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; DNA helicase activity [GO:0003678]; identical protein binding [GO:0042802]; single-stranded DNA binding [GO:0003697]; DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA unwinding involved in DNA replication [GO:0006268]; G1/S transition of mitotic cell cycle [GO:0000082]; mitotic cell cycle [GO:0000278]	DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA unwinding involved in DNA replication [GO:0006268]; G1/S transition of mitotic cell cycle [GO:0000082]; mitotic cell cycle [GO:0000278]	ATP binding [GO:0005524]; DNA helicase activity [GO:0003678]; identical protein binding [GO:0042802]; single-stranded DNA binding [GO:0003697]	MCM complex [GO:0042555]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005524; GO:0003678; GO:0006260; GO:0006270; GO:0006271; GO:0006268; GO:0000082; GO:0042555; GO:0042802; GO:0000278; GO:0005654; GO:0005634; GO:0003697	SUBCELLULAR LOCATION: Nucleus. Note=Binds to chromatin during G1 and detach from it during S phase.	3D-structure; ATP-binding; Acetylation; Cell cycle; Complete proteome; DNA replication; DNA-binding; Glycoprotein; Helicase; Hydrolase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome	Beta strand (2); Chain (1); Domain (1); Helix (5); Modified residue (6); Motif (1); Mutagenesis (3); Natural variant (2); Nucleotide binding (1); Sequence conflict (4); Turn (1)
AHSA1_HUMAN	O95433	AHSA1_HUMAN	reviewed	Activator of 90 kDa heat shock protein ATPase homolog 1 (AHA1) (p38)	AHSA1 C14orf3 HSPC322	Homo sapiens (Human)	338	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; ATPase activator activity [GO:0001671]; chaperone binding [GO:0051087]; positive regulation of ATPase activity [GO:0032781]; response to stress [GO:0006950]	positive regulation of ATPase activity [GO:0032781]; response to stress [GO:0006950]	ATPase activator activity [GO:0001671]; chaperone binding [GO:0051087]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]	GO:0001671; GO:0051087; GO:0005737; GO:0005829; GO:0005783; GO:0070062; GO:0032781; GO:0006950	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:11554768}. Endoplasmic reticulum {ECO:0000269|PubMed:11554768}. Note=May transiently interact with the endoplasmic reticulum.	3D-structure; Acetylation; Alternative splicing; Chaperone; Complete proteome; Cytoplasm; Endoplasmic reticulum; Phosphoprotein; Reference proteome; Stress response	Alternative sequence (1); Beta strand (5); Chain (1); Helix (4); Initiator methionine (1); Modified residue (4); Sequence conflict (1); Turn (3)
CAN1_HUMAN	P07384	CAN1_HUMAN	reviewed	Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP)	CAPN1 CANPL1 PIG30	Homo sapiens (Human)	714	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; positive regulation of cell proliferation [GO:0008284]; proteolysis [GO:0006508]; receptor catabolic process [GO:0032801]	extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; positive regulation of cell proliferation [GO:0008284]; proteolysis [GO:0006508]; receptor catabolic process [GO:0032801]	calcium-dependent cysteine-type endopeptidase activity [GO:0004198]; calcium ion binding [GO:0005509]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0005509; GO:0004198; GO:0005737; GO:0005829; GO:0070062; GO:0022617; GO:0030198; GO:0005925; GO:0016020; GO:0005886; GO:0008284; GO:0006508; GO:0032801	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8769305}. Cell membrane {ECO:0000269|PubMed:8769305}. Note=Translocates to the plasma membrane upon Ca(2+) binding.	3D-structure; Acetylation; Autocatalytic cleavage; Calcium; Cell membrane; Complete proteome; Cytoplasm; Hydrolase; Membrane; Metal-binding; Polymorphism; Protease; Reference proteome; Repeat; Thiol protease	Active site (3); Beta strand (15); Calcium binding (4); Chain (1); Domain (5); Helix (16); Initiator methionine (1); Modified residue (1); Natural variant (4); Region (3); Sequence conflict (1); Site (2)
RL36L_HUMAN	Q969Q0	RL36L_HUMAN	reviewed	60S ribosomal protein L36a-like	RPL36AL	Homo sapiens (Human)	106	cytosolic large ribosomal subunit [GO:0022625]; structural constituent of ribosome [GO:0003735]; translation [GO:0006412]	translation [GO:0006412]	structural constituent of ribosome [GO:0003735]	cytosolic large ribosomal subunit [GO:0022625]	GO:0022625; GO:0003735; GO:0006412	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.	Complete proteome; Cytoplasm; Direct protein sequencing; Methylation; Polymorphism; Reference proteome; Ribonucleoprotein; Ribosomal protein	Chain (1); Modified residue (1); Natural variant (1)
K7EK43_HUMAN	K7EK43	K7EK43_HUMAN	unreviewed	Tubulin beta-6 chain (Fragment)	TUBB6	Homo sapiens (Human)	31	microtubule [GO:0005874]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; microtubule-based process [GO:0007017]	microtubule-based process [GO:0007017]	GTPase activity [GO:0003924]; GTP binding [GO:0005525]	microtubule [GO:0005874]	GO:0005525; GO:0003924; GO:0005874; GO:0007017		Complete proteome; GTP-binding; Microtubule; Nucleotide-binding; Proteomics identification; Reference proteome	Non-terminal residue (1)
PLAP_HUMAN	Q9Y263	PLAP_HUMAN	reviewed	Phospholipase A-2-activating protein (PLA2P) (PLAP)	PLAA PLAP	Homo sapiens (Human)	795	extracellular exosome [GO:0070062]; phospholipase A2 activator activity [GO:0016005]; inflammatory response [GO:0006954]; phospholipid metabolic process [GO:0006644]; signal transduction [GO:0007165]	inflammatory response [GO:0006954]; phospholipid metabolic process [GO:0006644]; signal transduction [GO:0007165]	phospholipase A2 activator activity [GO:0016005]	extracellular exosome [GO:0070062]	GO:0070062; GO:0006954; GO:0016005; GO:0006644; GO:0007165		3D-structure; Acetylation; Complete proteome; Reference proteome; Repeat; WD repeat	Beta strand (5); Chain (1); Domain (2); Erroneous gene model prediction (1); Erroneous initiation (4); Erroneous termination (1); Frameshift (1); Helix (21); Modified residue (1); Repeat (13); Sequence conflict (11); Turn (3)
XPOT_HUMAN	O43592	XPOT_HUMAN	reviewed	Exportin-T (Exportin(tRNA)) (tRNA exportin)	XPOT	Homo sapiens (Human)	962	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; tRNA binding [GO:0000049]; intracellular protein transport [GO:0006886]; tRNA export from nucleus [GO:0006409]	intracellular protein transport [GO:0006886]; tRNA export from nucleus [GO:0006409]	tRNA binding [GO:0000049]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]	GO:0005737; GO:0006886; GO:0005654; GO:0000049; GO:0006409	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Nuclear, once bound to tRNA and Ran the complex translocates to the cytoplasm. Shuttles between the nucleus and the cytoplasm.	Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Polymorphism; RNA-binding; Reference proteome; Transport; tRNA-binding	Chain (1); Modified residue (2); Mutagenesis (5); Natural variant (2); Region (2); Sequence conflict (1)
J3QLE5_HUMAN	J3QLE5	J3QLE5_HUMAN	unreviewed	Small nuclear ribonucleoprotein-associated protein N (Fragment)	SNRPN	Homo sapiens (Human)	169	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; U1 snRNP [GO:0005685]; U2 snRNP [GO:0005686]; U2-type prespliceosome [GO:0071004]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; poly(A) RNA binding [GO:0044822]; mRNA splicing, via spliceosome [GO:0000398]	mRNA splicing, via spliceosome [GO:0000398]	poly(A) RNA binding [GO:0044822]	catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; U1 snRNP [GO:0005685]; U2 snRNP [GO:0005686]; U2-type prespliceosome [GO:0071004]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U4 snRNP [GO:0005687]; U5 snRNP [GO:0005682]	GO:0005685; GO:0005686; GO:0071004; GO:0005687; GO:0046540; GO:0005682; GO:0071013; GO:0005737; GO:0000398; GO:0044822		Complete proteome; Reference proteome	Non-terminal residue (1)
X6RK58_HUMAN	X6RK58	X6RK58_HUMAN	unreviewed	Leucine-rich repeat-containing protein 20 (Fragment)	LRRC20	Homo sapiens (Human)	175							Complete proteome; Leucine-rich repeat; Proteomics identification; Reference proteome; Repeat	Non-terminal residue (1)
PA1B3_HUMAN	Q15102	PA1B3_HUMAN	reviewed	Platelet-activating factor acetylhydrolase IB subunit gamma (EC 3.1.1.47) (PAF acetylhydrolase 29 kDa subunit) (PAF-AH 29 kDa subunit) (PAF-AH subunit gamma) (PAFAH subunit gamma)	PAFAH1B3 PAFAHG	Homo sapiens (Human)	231	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; 1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; identical protein binding [GO:0042802]; platelet-activating factor acetyltransferase activity [GO:0047179]; brain development [GO:0007420]; lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629]; nervous system development [GO:0007399]; spermatogenesis [GO:0007283]	brain development [GO:0007420]; lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629]; nervous system development [GO:0007399]; spermatogenesis [GO:0007283]	1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; identical protein binding [GO:0042802]; platelet-activating factor acetyltransferase activity [GO:0047179]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]	GO:0003847; GO:0007420; GO:0005737; GO:0005829; GO:0070062; GO:0042802; GO:0016042; GO:0006629; GO:0016020; GO:0007399; GO:0047179; GO:0007283	SUBCELLULAR LOCATION: Cytoplasm.	Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Lipid degradation; Lipid metabolism; Polymorphism; Reference proteome	Active site (3); Chain (1); Initiator methionine (1); Modified residue (1); Natural variant (1)
PTER_HUMAN	Q96BW5	PTER_HUMAN	reviewed	Phosphotriesterase-related protein (EC 3.1.-.-) (Parathion hydrolase-related protein) (hPHRP)	PTER	Homo sapiens (Human)	349	extracellular exosome [GO:0070062]; hydrolase activity, acting on ester bonds [GO:0016788]; zinc ion binding [GO:0008270]; catabolic process [GO:0009056]; epithelial cell differentiation [GO:0030855]	catabolic process [GO:0009056]; epithelial cell differentiation [GO:0030855]	hydrolase activity, acting on ester bonds [GO:0016788]; zinc ion binding [GO:0008270]	extracellular exosome [GO:0070062]	GO:0009056; GO:0030855; GO:0070062; GO:0016788; GO:0008270		Alternative splicing; Complete proteome; Hydrolase; Metal-binding; Polymorphism; Reference proteome	Alternative sequence (1); Chain (1); Metal binding (7); Natural variant (1); Sequence conflict (2)
PLSI_HUMAN	Q14651	PLSI_HUMAN	reviewed	Plastin-1 (Intestine-specific plastin) (I-plastin)	PLS1	Homo sapiens (Human)	629	brush border [GO:0005903]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; structural constituent of cytoskeleton [GO:0005200]; positive regulation of establishment of protein localization to plasma membrane [GO:0090004]	positive regulation of establishment of protein localization to plasma membrane [GO:0090004]	actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; structural constituent of cytoskeleton [GO:0005200]	brush border [GO:0005903]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]	GO:0051015; GO:0005903; GO:0005509; GO:0005737; GO:0070062; GO:0090004; GO:0005200	SUBCELLULAR LOCATION: Cytoplasm.	Acetylation; Actin-binding; Calcium; Complete proteome; Cytoplasm; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat	Calcium binding (2); Chain (1); Domain (8); Modified residue (13); Natural variant (2); Sequence conflict (3)
SYIC_HUMAN	P41252	SYIC_HUMAN	reviewed	Isoleucine--tRNA ligase, cytoplasmic (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IRS) (IleRS)	IARS	Homo sapiens (Human)	1262	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; GTPase binding [GO:0051020]; isoleucine-tRNA ligase activity [GO:0004822]; gene expression [GO:0010467]; isoleucyl-tRNA aminoacylation [GO:0006428]; osteoblast differentiation [GO:0001649]; tRNA aminoacylation for protein translation [GO:0006418]	gene expression [GO:0010467]; isoleucyl-tRNA aminoacylation [GO:0006428]; osteoblast differentiation [GO:0001649]; tRNA aminoacylation for protein translation [GO:0006418]	aminoacyl-tRNA editing activity [GO:0002161]; ATP binding [GO:0005524]; GTPase binding [GO:0051020]; isoleucine-tRNA ligase activity [GO:0004822]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]	GO:0005524; GO:0051020; GO:0002161; GO:0005737; GO:0005829; GO:0070062; GO:0010467; GO:0004822; GO:0006428; GO:0016020; GO:0005654; GO:0001649; GO:0006418	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:7721108}.	ATP-binding; Acetylation; Aminoacyl-tRNA synthetase; Complete proteome; Cytoplasm; Direct protein sequencing; Ligase; Nucleotide-binding; Phosphoprotein; Polymorphism; Protein biosynthesis; Reference proteome	Binding site (1); Chain (1); Erroneous initiation (1); Modified residue (3); Motif (2); Natural variant (5); Sequence conflict (1)
ELOC_HUMAN	Q15369	ELOC_HUMAN	reviewed	Transcription elongation factor B polypeptide 1 (Elongin 15 kDa subunit) (Elongin-C) (EloC) (RNA polymerase II transcription factor SIII subunit C) (SIII p15)	TCEB1	Homo sapiens (Human)	112	cytosol [GO:0005829]; elongin complex [GO:0070449]; nucleoplasm [GO:0005654]; cellular response to hypoxia [GO:0071456]; gene expression [GO:0010467]; positive regulation of transcription elongation from RNA polymerase II promoter [GO:0032968]; positive regulation of viral transcription [GO:0050434]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061418]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]; viral process [GO:0016032]	cellular response to hypoxia [GO:0071456]; gene expression [GO:0010467]; positive regulation of transcription elongation from RNA polymerase II promoter [GO:0032968]; positive regulation of viral transcription [GO:0050434]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061418]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]; viral process [GO:0016032]		cytosol [GO:0005829]; elongin complex [GO:0070449]; nucleoplasm [GO:0005654]	GO:0071456; GO:0005829; GO:0070449; GO:0010467; GO:0005654; GO:0032968; GO:0050434; GO:0042787; GO:0006357; GO:0061418; GO:0006368; GO:0006366; GO:0016032	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.	3D-structure; Alternative splicing; Complete proteome; Host-virus interaction; Nucleus; Reference proteome; Transcription; Transcription regulation; Ubl conjugation pathway	Alternative sequence (1); Beta strand (5); Chain (1); Helix (5); Turn (2)
ICLN_HUMAN	P54105	ICLN_HUMAN	reviewed	Methylosome subunit pICln (Chloride channel, nucleotide sensitive 1A) (Chloride conductance regulatory protein ICln) (I(Cln)) (Chloride ion current inducer protein) (ClCI) (Reticulocyte pICln)	CLNS1A CLCI ICLN	Homo sapiens (Human)	237	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pICln-Sm protein complex [GO:0034715]; plasma membrane [GO:0005886]; poly(A) RNA binding [GO:0044822]; protein heterodimerization activity [GO:0046982]; cell volume homeostasis [GO:0006884]; chloride transport [GO:0006821]; gene expression [GO:0010467]; ncRNA metabolic process [GO:0034660]; spliceosomal snRNP assembly [GO:0000387]	cell volume homeostasis [GO:0006884]; chloride transport [GO:0006821]; gene expression [GO:0010467]; ncRNA metabolic process [GO:0034660]; spliceosomal snRNP assembly [GO:0000387]	poly(A) RNA binding [GO:0044822]; protein heterodimerization activity [GO:0046982]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pICln-Sm protein complex [GO:0034715]; plasma membrane [GO:0005886]	GO:0006884; GO:0006821; GO:0005737; GO:0005856; GO:0005829; GO:0010467; GO:0034709; GO:0034660; GO:0005654; GO:0005634; GO:0034715; GO:0005886; GO:0044822; GO:0046982; GO:0000387	SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:18984161}. Nucleus {ECO:0000269|PubMed:18984161}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18984161}. Note=A small fraction is also associated with the cytoskeleton.	Acetylation; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome	Chain (1); Initiator methionine (1); Modified residue (4); Natural variant (2)
UBE2K_HUMAN	P61086	UBE2K_HUMAN	reviewed	Ubiquitin-conjugating enzyme E2 K (EC 6.3.2.19) (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase)	UBE2K HIP2 LIG	Homo sapiens (Human)	200	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intermediate filament cytoskeleton [GO:0045111]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ligase activity [GO:0016874]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-ubiquitin ligase activity [GO:0034450]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; ubiquitin-dependent protein catabolic process [GO:0006511]	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; ubiquitin-dependent protein catabolic process [GO:0006511]	ATP binding [GO:0005524]; ligase activity [GO:0016874]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-ubiquitin ligase activity [GO:0034450]	actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intermediate filament cytoskeleton [GO:0045111]; nucleus [GO:0005634]	GO:0005524; GO:0015629; GO:0005737; GO:0070062; GO:0045111; GO:0070059; GO:0016874; GO:0005634; GO:0043161; GO:0070936; GO:0032434; GO:0031625; GO:0006511; GO:0004842; GO:0034450	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.	3D-structure; ATP-binding; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Isopeptide bond; Ligase; Nucleotide-binding; Reference proteome; Ubl conjugation; Ubl conjugation pathway	Active site (1); Alternative sequence (2); Beta strand (6); Chain (1); Cross-link (1); Domain (1); Helix (9); Initiator methionine (1); Modified residue (2); Mutagenesis (1); Turn (6)
ELOB_HUMAN	Q15370	ELOB_HUMAN	reviewed	Transcription elongation factor B polypeptide 2 (Elongin 18 kDa subunit) (Elongin-B) (EloB) (RNA polymerase II transcription factor SIII subunit B) (SIII p18)	TCEB2	Homo sapiens (Human)	118	Cul2-RING ubiquitin ligase complex [GO:0031462]; Cul5-RING ubiquitin ligase complex [GO:0031466]; cytosol [GO:0005829]; elongin complex [GO:0070449]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; VCB complex [GO:0030891]; ubiquitin protein ligase binding [GO:0031625]; cellular response to hypoxia [GO:0071456]; gene expression [GO:0010467]; positive regulation of viral transcription [GO:0050434]; protein complex assembly [GO:0006461]; protein ubiquitination [GO:0016567]; regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061418]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]; viral process [GO:0016032]	cellular response to hypoxia [GO:0071456]; gene expression [GO:0010467]; positive regulation of viral transcription [GO:0050434]; protein complex assembly [GO:0006461]; protein ubiquitination [GO:0016567]; regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061418]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]; viral process [GO:0016032]	ubiquitin protein ligase binding [GO:0031625]	Cul2-RING ubiquitin ligase complex [GO:0031462]; Cul5-RING ubiquitin ligase complex [GO:0031466]; cytosol [GO:0005829]; elongin complex [GO:0070449]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; VCB complex [GO:0030891]	GO:0031462; GO:0031466; GO:0030891; GO:0071456; GO:0005829; GO:0070449; GO:0070062; GO:0010467; GO:0005654; GO:0050434; GO:0006461; GO:0016567; GO:0061418; GO:0006368; GO:0006366; GO:0031625; GO:0016032	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Nucleus; Reference proteome; Transcription; Transcription regulation; Ubl conjugation pathway	Alternative sequence (1); Beta strand (9); Chain (1); Domain (1); Erroneous gene model prediction (1); Helix (5); Modified residue (1); Turn (2)
RS6_HUMAN	P62753	RS6_HUMAN	reviewed	40S ribosomal protein S6 (Phosphoprotein NP33)	RPS6 OK/SW-cl.2	Homo sapiens (Human)	249	cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; dendrite [GO:0030425]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; polysome [GO:0005844]; ribonucleoprotein complex [GO:0030529]; small ribosomal subunit [GO:0015935]; poly(A) RNA binding [GO:0044822]; protein kinase binding [GO:0019901]; structural constituent of ribosome [GO:0003735]; activation-induced cell death of T cells [GO:0006924]; cellular protein metabolic process [GO:0044267]; erythrocyte development [GO:0048821]; G1/S transition of mitotic cell cycle [GO:0000082]; gastrulation [GO:0007369]; gene expression [GO:0010467]; glucose homeostasis [GO:0042593]; insulin receptor signaling pathway [GO:0008286]; mitotic cell cycle checkpoint [GO:0007093]; mitotic nuclear division [GO:0007067]; negative regulation of apoptotic process [GO:0043066]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; oogenesis stage [GO:0022605]; placenta development [GO:0001890]; positive regulation of apoptotic process [GO:0043065]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; T cell differentiation in thymus [GO:0033077]; T cell proliferation involved in immune response [GO:0002309]; TOR signaling [GO:0031929]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	activation-induced cell death of T cells [GO:0006924]; cellular protein metabolic process [GO:0044267]; erythrocyte development [GO:0048821]; G1/S transition of mitotic cell cycle [GO:0000082]; gastrulation [GO:0007369]; gene expression [GO:0010467]; glucose homeostasis [GO:0042593]; insulin receptor signaling pathway [GO:0008286]; mitotic cell cycle checkpoint [GO:0007093]; mitotic nuclear division [GO:0007067]; negative regulation of apoptotic process [GO:0043066]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; oogenesis stage [GO:0022605]; placenta development [GO:0001890]; positive regulation of apoptotic process [GO:0043065]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; T cell differentiation in thymus [GO:0033077]; T cell proliferation involved in immune response [GO:0002309]; TOR signaling [GO:0031929]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	poly(A) RNA binding [GO:0044822]; protein kinase binding [GO:0019901]; structural constituent of ribosome [GO:0003735]	cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; dendrite [GO:0030425]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; polysome [GO:0005844]; ribonucleoprotein complex [GO:0030529]; small ribosomal subunit [GO:0015935]	GO:0000082; GO:0006614; GO:0033077; GO:0002309; GO:0031929; GO:0006924; GO:0044297; GO:0044267; GO:0005737; GO:0036464; GO:0005829; GO:0022627; GO:0030425; GO:0048821; GO:0007369; GO:0010467; GO:0042593; GO:0008286; GO:0016020; GO:0007093; GO:0007067; GO:0043066; GO:0000184; GO:0005730; GO:0005634; GO:0022605; GO:0048471; GO:0001890; GO:0044822; GO:0005844; GO:0043065; GO:0019901; GO:0006364; GO:0030529; GO:0000028; GO:0042274; GO:0015935; GO:0003735; GO:0006412; GO:0006414; GO:0006413; GO:0006415; GO:0019058; GO:0016032; GO:0019083		3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Phosphoprotein; Polymorphism; Reference proteome; Ribonucleoprotein; Ribosomal protein	Chain (1); Modified residue (7); Mutagenesis (1); Natural variant (1); Sequence conflict (6)
MCM4_HUMAN	P33991	MCM4_HUMAN	reviewed	DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21)	MCM4 CDC21	Homo sapiens (Human)	863	MCM complex [GO:0042555]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; DNA helicase activity [GO:0003678]; single-stranded DNA binding [GO:0003697]; DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA unwinding involved in DNA replication [GO:0006268]; G1/S transition of mitotic cell cycle [GO:0000082]; mitotic cell cycle [GO:0000278]	DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA unwinding involved in DNA replication [GO:0006268]; G1/S transition of mitotic cell cycle [GO:0000082]; mitotic cell cycle [GO:0000278]	ATP binding [GO:0005524]; DNA helicase activity [GO:0003678]; single-stranded DNA binding [GO:0003697]	MCM complex [GO:0042555]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005524; GO:0003678; GO:0006260; GO:0006270; GO:0006271; GO:0006268; GO:0000082; GO:0042555; GO:0016020; GO:0000278; GO:0005654; GO:0005634; GO:0003697	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.	ATP-binding; Acetylation; Cell cycle; Complete proteome; DNA replication; DNA-binding; Helicase; Hydrolase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome	Chain (1); Domain (1); Initiator methionine (1); Modified residue (12); Motif (1); Natural variant (2); Nucleotide binding (1); Sequence conflict (2)
C9K020_HUMAN	C9K020	C9K020_HUMAN	unreviewed	WD repeat-containing protein 6 (Fragment)	WDR6	Homo sapiens (Human)	271	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]			cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0005737; GO:0005886		Complete proteome; Proteomics identification; Reference proteome; Repeat; WD repeat	Non-terminal residue (1)
OTU7A_HUMAN	Q8TE49	OTU7A_HUMAN	reviewed	OTU domain-containing protein 7A (EC 3.4.19.12) (Zinc finger protein Cezanne 2)	OTUD7A C15orf16 CEZANNE2 OTUD7	Homo sapiens (Human)	926	cytoplasm [GO:0005737]; nucleus [GO:0005634]; DNA binding [GO:0003677]; ubiquitin-specific protease activity [GO:0004843]; zinc ion binding [GO:0008270]; protein K11-linked deubiquitination [GO:0035871]	protein K11-linked deubiquitination [GO:0035871]	DNA binding [GO:0003677]; ubiquitin-specific protease activity [GO:0004843]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0003677; GO:0005737; GO:0005634; GO:0035871; GO:0004843; GO:0008270	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.	3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Metal-binding; Nucleus; Protease; Reference proteome; Thiol protease; Ubl conjugation pathway; Zinc; Zinc-finger	Active site (3); Alternative sequence (1); Beta strand (3); Chain (1); Domain (1); Helix (3); Motif (1); Region (2); Turn (1); Zinc finger (1)
BID_HUMAN	P55957	BID_HUMAN	reviewed	BH3-interacting domain death agonist (p22 BID) (BID) [Cleaved into: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domain death agonist p13 (p13 BID); BH3-interacting domain death agonist p11 (p11 BID)]	BID	Homo sapiens (Human)	195	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; integral component of mitochondrial membrane [GO:0032592]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; death receptor binding [GO:0005123]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic mitochondrial changes [GO:0008637]; apoptotic process [GO:0006915]; brain development [GO:0007420]; establishment of protein localization to membrane [GO:0090150]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; glial cell apoptotic process [GO:0034349]; hepatocyte apoptotic process [GO:0097284]; intrinsic apoptotic signaling pathway [GO:0097193]; mitochondrial outer membrane permeabilization [GO:0097345]; neuron apoptotic process [GO:0051402]; positive regulation of apoptotic process [GO:0043065]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of protein homooligomerization [GO:0032464]; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [GO:1900740]; positive regulation of protein oligomerization [GO:0032461]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; programmed cell death [GO:0012501]; protein homooligomerization [GO:0051260]; protein targeting to mitochondrion [GO:0006626]; regulation of cell proliferation [GO:0042127]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; release of cytochrome c from mitochondria [GO:0001836]; response to estradiol [GO:0032355]; signal transduction in response to DNA damage [GO:0042770]	activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic mitochondrial changes [GO:0008637]; apoptotic process [GO:0006915]; brain development [GO:0007420]; establishment of protein localization to membrane [GO:0090150]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; glial cell apoptotic process [GO:0034349]; hepatocyte apoptotic process [GO:0097284]; intrinsic apoptotic signaling pathway [GO:0097193]; mitochondrial outer membrane permeabilization [GO:0097345]; neuron apoptotic process [GO:0051402]; positive regulation of apoptotic process [GO:0043065]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of protein homooligomerization [GO:0032464]; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [GO:1900740]; positive regulation of protein oligomerization [GO:0032461]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; programmed cell death [GO:0012501]; protein homooligomerization [GO:0051260]; protein targeting to mitochondrion [GO:0006626]; regulation of cell proliferation [GO:0042127]; regulation of G1/S transition of mitotic cell cycle [GO:2000045]; release of cytochrome c from mitochondria [GO:0001836]; response to estradiol [GO:0032355]; signal transduction in response to DNA damage [GO:0042770]	death receptor binding [GO:0005123]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; integral component of mitochondrial membrane [GO:0032592]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]	GO:0006919; GO:0008637; GO:0006915; GO:0007420; GO:0005829; GO:0005123; GO:0090150; GO:0070062; GO:0008625; GO:0034349; GO:0097284; GO:0032592; GO:0097193; GO:0016020; GO:0005741; GO:0097345; GO:0005739; GO:0051402; GO:0043065; GO:2001238; GO:2001244; GO:1901030; GO:0032464; GO:1900740; GO:0032461; GO:0090200; GO:0012501; GO:0051260; GO:0006626; GO:2000045; GO:0042127; GO:0001836; GO:0032355; GO:0042770	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Mitochondrion membrane {ECO:0000250}. Note=When uncleaved, it is predominantly cytoplasmic. {ECO:0000269|PubMed:14583606}.; SUBCELLULAR LOCATION: BH3-interacting domain death agonist p15: Mitochondrion membrane {ECO:0000250}. Note=Translocates to mitochondria as an integral membrane protein. {ECO:0000250}.; SUBCELLULAR LOCATION: BH3-interacting domain death agonist p13: Mitochondrion membrane {ECO:0000250}. Note=Associated with the mitochondrial membrane. {ECO:0000250}.; SUBCELLULAR LOCATION: Isoform 1: Cytoplasm.; SUBCELLULAR LOCATION: Isoform 3: Cytoplasm.; SUBCELLULAR LOCATION: Isoform 2: Mitochondrion membrane. Note=A significant proportion of isoform 2 localizes to mitochondria, it may be cleaved constitutively.	3D-structure; Acetylation; Alternative splicing; Apoptosis; Complete proteome; Cytoplasm; Membrane; Mitochondrion; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation	Alternative sequence (4); Beta strand (1); Chain (4); Erroneous initiation (1); Helix (10); Modified residue (3); Motif (1); Natural variant (3); Site (3); Turn (2)
EI2BA_HUMAN	Q14232	EI2BA_HUMAN	reviewed	Translation initiation factor eIF-2B subunit alpha (eIF-2B GDP-GTP exchange factor subunit alpha)	EIF2B1 EIF2BA	Homo sapiens (Human)	305	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2B complex [GO:0005851]; membrane [GO:0016020]; plasma membrane [GO:0005886]; enzyme regulator activity [GO:0030234]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; translation initiation factor activity [GO:0003743]; cellular protein metabolic process [GO:0044267]; cellular response to stimulus [GO:0051716]; gene expression [GO:0010467]; negative regulation of translational initiation in response to stress [GO:0032057]; oligodendrocyte development [GO:0014003]; positive regulation of GTPase activity [GO:0043547]; regulation of translational initiation [GO:0006446]; response to glucose [GO:0009749]; response to heat [GO:0009408]; response to peptide hormone [GO:0043434]; translation [GO:0006412]; translational initiation [GO:0006413]	cellular protein metabolic process [GO:0044267]; cellular response to stimulus [GO:0051716]; gene expression [GO:0010467]; negative regulation of translational initiation in response to stress [GO:0032057]; oligodendrocyte development [GO:0014003]; positive regulation of GTPase activity [GO:0043547]; regulation of translational initiation [GO:0006446]; response to glucose [GO:0009749]; response to heat [GO:0009408]; response to peptide hormone [GO:0043434]; translation [GO:0006412]; translational initiation [GO:0006413]	enzyme regulator activity [GO:0030234]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; translation initiation factor activity [GO:0003743]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; eukaryotic translation initiation factor 2B complex [GO:0005851]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0019003; GO:0005525; GO:0044267; GO:0051716; GO:0005737; GO:0005829; GO:0030234; GO:0005851; GO:0010467; GO:0016020; GO:0032057; GO:0014003; GO:0005886; GO:0043547; GO:0006446; GO:0009749; GO:0009408; GO:0043434; GO:0006412; GO:0003743; GO:0006413		3D-structure; Acetylation; Alternative splicing; Complete proteome; Disease mutation; Initiation factor; Leukodystrophy; Protein biosynthesis; Reference proteome	Alternative sequence (2); Beta strand (10); Chain (1); Helix (19); Modified residue (1); Natural variant (2); Turn (4)
ZN326_HUMAN	Q5BKZ1	ZN326_HUMAN	reviewed	DBIRD complex subunit ZNF326 (Zinc finger protein 326) (Zinc finger protein interacting with mRNPs and DBC1)	ZNF326 ZIRD	Homo sapiens (Human)	582	DBIRD complex [GO:0044609]; intracellular membrane-bounded organelle [GO:0043231]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; poly(A) RNA binding [GO:0044822]; RNA polymerase II core binding [GO:0000993]; zinc ion binding [GO:0008270]; mRNA processing [GO:0006397]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of DNA-templated transcription, elongation [GO:0032784]; RNA splicing [GO:0008380]; transcription, DNA-templated [GO:0006351]	mRNA processing [GO:0006397]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of DNA-templated transcription, elongation [GO:0032784]; RNA splicing [GO:0008380]; transcription, DNA-templated [GO:0006351]	DNA binding [GO:0003677]; poly(A) RNA binding [GO:0044822]; RNA polymerase II core binding [GO:0000993]; zinc ion binding [GO:0008270]	DBIRD complex [GO:0044609]; intracellular membrane-bounded organelle [GO:0043231]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]	GO:0044609; GO:0003677; GO:0000993; GO:0008380; GO:0043231; GO:0006397; GO:0016363; GO:0005654; GO:0044822; GO:0045893; GO:0032784; GO:0006351; GO:0008270	SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000250}.	Acetylation; Activator; Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger; mRNA processing; mRNA splicing	Alternative sequence (2); Chain (1); Compositional bias (2); Erroneous gene model prediction (2); Modified residue (7); Motif (1); Region (1); Sequence caution (2); Sequence conflict (1); Zinc finger (2)
TOM1_HUMAN	O60784	TOM1_HUMAN	reviewed	Target of Myb protein 1	TOM1	Homo sapiens (Human)	492	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; clathrin binding [GO:0030276]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; intracellular protein transport [GO:0006886]; protein transport [GO:0015031]	endocytosis [GO:0006897]; endosomal transport [GO:0016197]; intracellular protein transport [GO:0006886]; protein transport [GO:0015031]	clathrin binding [GO:0030276]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; membrane [GO:0016020]	GO:0030276; GO:0005737; GO:0005829; GO:0005769; GO:0006897; GO:0016197; GO:0005768; GO:0070062; GO:0006886; GO:0016020; GO:0015031	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Membrane; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport	Alternative sequence (3); Beta strand (1); Chain (1); Domain (2); Helix (13); Modified residue (9); Natural variant (2); Sequence conflict (3); Turn (2)
VATA_HUMAN	P38606	VATA_HUMAN	reviewed	V-type proton ATPase catalytic subunit A (V-ATPase subunit A) (EC 3.6.3.14) (V-ATPase 69 kDa subunit) (Vacuolar ATPase isoform VA68) (Vacuolar proton pump subunit alpha)	ATP6V1A ATP6A1 ATP6V1A1 VPP2	Homo sapiens (Human)	617	apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; integral component of plasma membrane [GO:0005887]; lysosomal membrane [GO:0005765]; microvillus [GO:0005902]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; proton-transporting two-sector ATPase complex [GO:0016469]; proton-transporting V-type ATPase, V1 domain [GO:0033180]; ATP binding [GO:0005524]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; ATP hydrolysis coupled proton transport [GO:0015991]; ATP metabolic process [GO:0046034]; cellular iron ion homeostasis [GO:0006879]; insulin receptor signaling pathway [GO:0008286]; interaction with host [GO:0051701]; ion transmembrane transport [GO:0034220]; phagosome maturation [GO:0090382]; transferrin transport [GO:0033572]; transmembrane transport [GO:0055085]; transport [GO:0006810]	ATP hydrolysis coupled proton transport [GO:0015991]; ATP metabolic process [GO:0046034]; cellular iron ion homeostasis [GO:0006879]; insulin receptor signaling pathway [GO:0008286]; interaction with host [GO:0051701]; ion transmembrane transport [GO:0034220]; phagosome maturation [GO:0090382]; transferrin transport [GO:0033572]; transmembrane transport [GO:0055085]; transport [GO:0006810]	ATP binding [GO:0005524]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]	apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; integral component of plasma membrane [GO:0005887]; lysosomal membrane [GO:0005765]; microvillus [GO:0005902]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; proton-transporting two-sector ATPase complex [GO:0016469]; proton-transporting V-type ATPase, V1 domain [GO:0033180]	GO:0005524; GO:0015991; GO:0046034; GO:0016324; GO:0006879; GO:0005829; GO:0070062; GO:0008286; GO:0005887; GO:0051701; GO:0034220; GO:0005765; GO:0005902; GO:0005739; GO:0090382; GO:0005886; GO:0046961; GO:0033180; GO:0016469; GO:0033572; GO:0055085; GO:0006810		ATP-binding; Acetylation; Alternative splicing; Complete proteome; Hydrogen ion transport; Hydrolase; Ion transport; Nucleotide-binding; Reference proteome; Transport	Alternative sequence (1); Chain (1); Nucleotide binding (1); Sequence conflict (4)
ILKAP_HUMAN	Q9H0C8	ILKAP_HUMAN	reviewed	Integrin-linked kinase-associated serine/threonine phosphatase 2C (ILKAP) (EC 3.1.3.16)	ILKAP	Homo sapiens (Human)	392	cytoplasm [GO:0005737]; metal ion binding [GO:0046872]; protein serine/threonine phosphatase activity [GO:0004722]; protein dephosphorylation [GO:0006470]; regulation of nuclear cell cycle DNA replication [GO:0033262]	protein dephosphorylation [GO:0006470]; regulation of nuclear cell cycle DNA replication [GO:0033262]	metal ion binding [GO:0046872]; protein serine/threonine phosphatase activity [GO:0004722]	cytoplasm [GO:0005737]	GO:0005737; GO:0046872; GO:0006470; GO:0004722; GO:0033262	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11331582}.	Acetylation; Complete proteome; Cytoplasm; Hydrolase; Magnesium; Manganese; Metal-binding; Phosphoprotein; Polymorphism; Protein phosphatase; Reference proteome	Chain (1); Domain (1); Metal binding (5); Modified residue (3); Mutagenesis (3); Natural variant (1)
AGM1_HUMAN	O95394	AGM1_HUMAN	reviewed	Phosphoacetylglucosamine mutase (PAGM) (EC 5.4.2.3) (Acetylglucosamine phosphomutase) (N-acetylglucosamine-phosphate mutase) (Phosphoglucomutase-3) (PGM 3)	PGM3 AGM1	Homo sapiens (Human)	542	cytosol [GO:0005829]; magnesium ion binding [GO:0000287]; phosphoacetylglucosamine mutase activity [GO:0004610]; phosphoglucomutase activity [GO:0004614]; cellular protein metabolic process [GO:0044267]; dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; glucosamine metabolic process [GO:0006041]; glucose 1-phosphate metabolic process [GO:0019255]; hemopoiesis [GO:0030097]; post-translational protein modification [GO:0043687]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; protein O-linked glycosylation [GO:0006493]; spermatogenesis [GO:0007283]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]	cellular protein metabolic process [GO:0044267]; dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; glucosamine metabolic process [GO:0006041]; glucose 1-phosphate metabolic process [GO:0019255]; hemopoiesis [GO:0030097]; post-translational protein modification [GO:0043687]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; protein O-linked glycosylation [GO:0006493]; spermatogenesis [GO:0007283]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]	magnesium ion binding [GO:0000287]; phosphoacetylglucosamine mutase activity [GO:0004610]; phosphoglucomutase activity [GO:0004614]	cytosol [GO:0005829]	GO:0006048; GO:0044267; GO:0005829; GO:0006488; GO:0006041; GO:0019255; GO:0030097; GO:0000287; GO:0004610; GO:0004614; GO:0043687; GO:0006487; GO:0018279; GO:0006493; GO:0007283		Acetylation; Alternative splicing; Carbohydrate metabolism; Complete proteome; Disease mutation; Isomerase; Magnesium; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome	Active site (1); Alternative sequence (2); Binding site (1); Chain (1); Erroneous initiation (1); Metal binding (4); Modified residue (3); Mutagenesis (4); Natural variant (9); Region (2); Sequence conflict (2)
RNH2A_HUMAN	O75792	RNH2A_HUMAN	reviewed	Ribonuclease H2 subunit A (RNase H2 subunit A) (EC 3.1.26.4) (Aicardi-Goutieres syndrome 4 protein) (AGS4) (RNase H(35)) (Ribonuclease HI large subunit) (RNase HI large subunit) (Ribonuclease HI subunit A)	RNASEH2A RNASEHI RNHIA	Homo sapiens (Human)	299	nucleus [GO:0005634]; ribonuclease H2 complex [GO:0032299]; metal ion binding [GO:0046872]; ribonuclease activity [GO:0004540]; RNA binding [GO:0003723]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; DNA replication [GO:0006260]; DNA replication, removal of RNA primer [GO:0043137]; mismatch repair [GO:0006298]; RNA catabolic process [GO:0006401]; RNA phosphodiester bond hydrolysis [GO:0090501]; RNA phosphodiester bond hydrolysis, endonucleolytic [GO:0090502]	DNA replication [GO:0006260]; DNA replication, removal of RNA primer [GO:0043137]; mismatch repair [GO:0006298]; RNA catabolic process [GO:0006401]; RNA phosphodiester bond hydrolysis [GO:0090501]; RNA phosphodiester bond hydrolysis, endonucleolytic [GO:0090502]	metal ion binding [GO:0046872]; ribonuclease activity [GO:0004540]; RNA binding [GO:0003723]; RNA-DNA hybrid ribonuclease activity [GO:0004523]	nucleus [GO:0005634]; ribonuclease H2 complex [GO:0032299]	GO:0006260; GO:0043137; GO:0003723; GO:0006401; GO:0090501; GO:0090502; GO:0004523; GO:0046872; GO:0006298; GO:0005634; GO:0032299; GO:0004540	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.	3D-structure; Acetylation; Aicardi-Goutieres syndrome; Complete proteome; Disease mutation; Endonuclease; Hydrolase; Metal-binding; Nuclease; Nucleus; Phosphoprotein; Polymorphism; Reference proteome	Beta strand (10); Chain (1); Helix (12); Metal binding (3); Modified residue (4); Mutagenesis (6); Natural variant (13); Sequence conflict (1); Turn (1)
CTBL1_HUMAN	Q8WYA6	CTBL1_HUMAN	reviewed	Beta-catenin-like protein 1 (Nuclear-associated protein) (NAP) (Testis development protein NYD-SP19)	CTNNBL1 C20orf33 PP8304	Homo sapiens (Human)	563	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Prp19 complex [GO:0000974]; spliceosomal complex [GO:0005681]; enzyme binding [GO:0019899]; apoptotic process [GO:0006915]; gene expression [GO:0010467]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of apoptotic process [GO:0043065]; RNA splicing [GO:0008380]; somatic diversification of immunoglobulins [GO:0016445]	apoptotic process [GO:0006915]; gene expression [GO:0010467]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of apoptotic process [GO:0043065]; RNA splicing [GO:0008380]; somatic diversification of immunoglobulins [GO:0016445]	enzyme binding [GO:0019899]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Prp19 complex [GO:0000974]; spliceosomal complex [GO:0005681]	GO:0000974; GO:0008380; GO:0006915; GO:0005737; GO:0019899; GO:0010467; GO:0000398; GO:0016020; GO:0005654; GO:0005634; GO:0043065; GO:0016445; GO:0005681	SUBCELLULAR LOCATION: Isoform 1: Nucleus.; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm {ECO:0000305}.	3D-structure; Acetylation; Alternative splicing; Apoptosis; Coiled coil; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Spliceosome; mRNA processing; mRNA splicing	Alternative sequence (4); Beta strand (4); Chain (1); Coiled coil (1); Compositional bias (2); Erroneous initiation (1); Frameshift (1); Helix (32); Modified residue (4); Motif (2); Mutagenesis (2); Natural variant (1); Repeat (7); Sequence conflict (6); Turn (4)
NUBP2_HUMAN	Q9Y5Y2	NUBP2_HUMAN	reviewed	Cytosolic Fe-S cluster assembly factor NUBP2 (Nucleotide-binding protein 2) (NBP 2)	NUBP2	Homo sapiens (Human)	271	cytoplasm [GO:0005737]; nucleus [GO:0005634]; spindle pole centrosome [GO:0031616]; 4 iron, 4 sulfur cluster binding [GO:0051539]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]; iron-sulfur cluster assembly [GO:0016226]; small molecule metabolic process [GO:0044281]	iron-sulfur cluster assembly [GO:0016226]; small molecule metabolic process [GO:0044281]	4 iron, 4 sulfur cluster binding [GO:0051539]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; spindle pole centrosome [GO:0031616]	GO:0051539; GO:0005524; GO:0005737; GO:0016226; GO:0046872; GO:0000166; GO:0005634; GO:0044281; GO:0031616	SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03039}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP-Rule:MF_03039}. Note=Enriched at the centrosomes during mitosis. {ECO:0000255|HAMAP-Rule:MF_03039}.	4Fe-4S; ATP-binding; Acetylation; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Iron; Iron-sulfur; Metal-binding; Nucleotide-binding; Nucleus; Polymorphism; Reference proteome	Chain (1); Metal binding (2); Modified residue (1); Natural variant (3); Nucleotide binding (1); Sequence conflict (1)
D6RDK5_HUMAN	D6RDK5	D6RDK5_HUMAN	unreviewed	Protein Spindly	SPDL1	Homo sapiens (Human)	44							Complete proteome; Proteomics identification; Reference proteome	
DCUP_HUMAN	P06132	DCUP_HUMAN	reviewed	Uroporphyrinogen decarboxylase (UPD) (URO-D) (EC 4.1.1.37)	UROD	Homo sapiens (Human)	367	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; uroporphyrinogen decarboxylase activity [GO:0004853]; heme biosynthetic process [GO:0006783]; porphyrin-containing compound metabolic process [GO:0006778]; protoporphyrinogen IX biosynthetic process [GO:0006782]; small molecule metabolic process [GO:0044281]	heme biosynthetic process [GO:0006783]; porphyrin-containing compound metabolic process [GO:0006778]; protoporphyrinogen IX biosynthetic process [GO:0006782]; small molecule metabolic process [GO:0044281]	uroporphyrinogen decarboxylase activity [GO:0004853]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	GO:0005737; GO:0005829; GO:0006783; GO:0005654; GO:0006778; GO:0006782; GO:0044281; GO:0004853	SUBCELLULAR LOCATION: Cytoplasm.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Decarboxylase; Direct protein sequencing; Disease mutation; Heme biosynthesis; Lyase; Porphyrin biosynthesis; Reference proteome	Beta strand (9); Binding site (6); Chain (1); Helix (21); Modified residue (1); Mutagenesis (4); Natural variant (41); Region (1); Sequence conflict (5); Site (1); Turn (2)
FLII_HUMAN	Q13045	FLII_HUMAN	reviewed	Protein flightless-1 homolog	FLII FLIL	Homo sapiens (Human)	1269	cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; actin binding [GO:0003779]; actin cytoskeleton organization [GO:0030036]; actin filament severing [GO:0051014]; multicellular organismal development [GO:0007275]; muscle contraction [GO:0006936]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]	actin cytoskeleton organization [GO:0030036]; actin filament severing [GO:0051014]; multicellular organismal development [GO:0007275]; muscle contraction [GO:0006936]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]	actin binding [GO:0003779]	cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]	GO:0003779; GO:0030036; GO:0051014; GO:0005737; GO:0005925; GO:0005815; GO:0007275; GO:0006936; GO:0005654; GO:0006355; GO:0006351	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Note=Colocalizes to actin-rich structures in blastocysts and, together with HRAS, RHOA and CDC42, in migrating fibroblasts. Localizes to centrosomes (By similarity). {ECO:0000250}.	Acetylation; Actin-binding; Activator; Alternative splicing; Cell junction; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Direct protein sequencing; Leucine-rich repeat; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation	Alternative sequence (3); Chain (1); Compositional bias (2); Erroneous initiation (1); Modified residue (6); Mutagenesis (2); Natural variant (1); Region (2); Repeat (20); Sequence conflict (2)
OTU6B_HUMAN	Q8N6M0	OTU6B_HUMAN	reviewed	OTU domain-containing protein 6B (EC 3.4.19.12) (DUBA-5)	OTUD6B DUBA5 CGI-77	Homo sapiens (Human)	293	cysteine-type peptidase activity [GO:0008234]		cysteine-type peptidase activity [GO:0008234]		GO:0008234		Acetylation; Alternative splicing; Complete proteome; Hydrolase; Polymorphism; Protease; Reference proteome; Thiol protease; Ubl conjugation pathway	Active site (3); Alternative sequence (1); Chain (1); Domain (1); Modified residue (1); Natural variant (1); Region (3); Sequence conflict (1)
J3QSV6_HUMAN	J3QSV6	J3QSV6_HUMAN	unreviewed	Ribosomal L1 domain-containing protein 1 (Fragment)	RSL1D1	Homo sapiens (Human)	430	nucleolus [GO:0005730]; RNA binding [GO:0003723]		RNA binding [GO:0003723]	nucleolus [GO:0005730]	GO:0003723; GO:0005730		Complete proteome; Proteomics identification; Reference proteome	Non-terminal residue (1)
NPM_HUMAN	P06748	NPM_HUMAN	reviewed	Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin)	NPM1 NPM	Homo sapiens (Human)	294	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]; spindle pole centrosome [GO:0031616]; histone binding [GO:0042393]; NF-kappaB binding [GO:0051059]; poly(A) RNA binding [GO:0044822]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]; ribosomal large subunit binding [GO:0043023]; ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; Tat protein binding [GO:0030957]; transcription coactivator activity [GO:0003713]; unfolded protein binding [GO:0051082]; cell aging [GO:0007569]; CENP-A containing nucleosome assembly [GO:0034080]; centrosome cycle [GO:0007098]; DNA repair [GO:0006281]; intracellular protein transport [GO:0006886]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell proliferation [GO:0008285]; negative regulation of centrosome duplication [GO:0010826]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; nucleocytoplasmic transport [GO:0006913]; nucleosome assembly [GO:0006334]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of translation [GO:0045727]; protein localization [GO:0008104]; protein oligomerization [GO:0051259]; regulation of centriole replication [GO:0046599]; regulation of eIF2 alpha phosphorylation by dsRNA [GO:0060735]; regulation of endodeoxyribonuclease activity [GO:0032071]; regulation of endoribonuclease activity [GO:0060699]; response to stress [GO:0006950]; ribosome assembly [GO:0042255]; signal transduction [GO:0007165]; viral process [GO:0016032]	cell aging [GO:0007569]; CENP-A containing nucleosome assembly [GO:0034080]; centrosome cycle [GO:0007098]; DNA repair [GO:0006281]; intracellular protein transport [GO:0006886]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell proliferation [GO:0008285]; negative regulation of centrosome duplication [GO:0010826]; negative regulation of protein kinase activity by regulation of protein phosphorylation [GO:0044387]; nucleocytoplasmic transport [GO:0006913]; nucleosome assembly [GO:0006334]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of translation [GO:0045727]; protein localization [GO:0008104]; protein oligomerization [GO:0051259]; regulation of centriole replication [GO:0046599]; regulation of eIF2 alpha phosphorylation by dsRNA [GO:0060735]; regulation of endodeoxyribonuclease activity [GO:0032071]; regulation of endoribonuclease activity [GO:0060699]; response to stress [GO:0006950]; ribosome assembly [GO:0042255]; signal transduction [GO:0007165]; viral process [GO:0016032]	histone binding [GO:0042393]; NF-kappaB binding [GO:0051059]; poly(A) RNA binding [GO:0044822]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]; ribosomal large subunit binding [GO:0043023]; ribosomal small subunit binding [GO:0043024]; RNA binding [GO:0003723]; Tat protein binding [GO:0030957]; transcription coactivator activity [GO:0003713]; unfolded protein binding [GO:0051082]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]; spindle pole centrosome [GO:0031616]	GO:0034080; GO:0006281; GO:0051059; GO:0003723; GO:0030957; GO:0007569; GO:0005813; GO:0007098; GO:0005737; GO:0005829; GO:0005925; GO:0042393; GO:0006886; GO:0016020; GO:0043066; GO:0008285; GO:0010826; GO:0044387; GO:0006913; GO:0005730; GO:0005654; GO:0006334; GO:0005634; GO:0044822; GO:0051092; GO:0045727; GO:0046982; GO:0042803; GO:0019901; GO:0004860; GO:0008104; GO:0051259; GO:0046599; GO:0060735; GO:0032071; GO:0060699; GO:0006950; GO:0030529; GO:0043023; GO:0043024; GO:0042255; GO:0007165; GO:0031616; GO:0003713; GO:0051082; GO:0016032	SUBCELLULAR LOCATION: Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Generally nucleolar, but is translocated to the nucleoplasm in case of serum starvation or treatment with anticancer drugs. Has been found in the cytoplasm in patients with primary acute myelogenous leukemia (AML), but not with secondary AML. Can shuttle between cytoplasm and nucleus. Co- localizes with the methylated form of RPS10 in the granular component (GC) region of the nucleolus. Colocalized with nucleolin and APEX1 in nucleoli. Isoform 1 of NEK2 is required for its localization to the centrosome during mitosis.	3D-structure; ADP-ribosylation; Acetylation; Alternative splicing; Chaperone; Chromosomal rearrangement; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Disulfide bond; Host-virus interaction; Isopeptide bond; Nucleus; Phosphoprotein; Proto-oncogene; RNA-binding; Reference proteome; Ubl conjugation	Alternative sequence (2); Beta strand (8); Chain (1); Compositional bias (3); Cross-link (2); Helix (3); Modified residue (30); Motif (2); Mutagenesis (17); Region (3); Sequence conflict (21); Site (3); Turn (1)
CDK1_HUMAN	P06493	CDK1_HUMAN	reviewed	Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)	CDK1 CDC2 CDC28A CDKN1 P34CDC2	Homo sapiens (Human)	297	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; midbody [GO:0030496]; mitochondrion [GO:0005739]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle microtubule [GO:0005876]; ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; histone kinase activity [GO:0035173]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II carboxy-terminal domain kinase activity [GO:0008353]; activation of MAPK activity [GO:0000187]; activation of MAPKK activity [GO:0000186]; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; apoptotic process [GO:0006915]; axon guidance [GO:0007411]; cell aging [GO:0007569]; cell division [GO:0051301]; cell migration [GO:0016477]; cellular response to hydrogen peroxide [GO:0070301]; centrosome cycle [GO:0007098]; chromosome condensation [GO:0030261]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; epidermal growth factor receptor signaling pathway [GO:0007173]; epithelial cell differentiation [GO:0030855]; Fc-epsilon receptor signaling pathway [GO:0038095]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; innate immune response [GO:0045087]; insulin receptor signaling pathway [GO:0008286]; MAPK cascade [GO:0000165]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]; mitotic G2 DNA damage checkpoint [GO:0007095]; mitotic nuclear division [GO:0007067]; mitotic nuclear envelope disassembly [GO:0007077]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; MyD88-independent toll-like receptor signaling pathway [GO:0002756]; negative regulation of apoptotic process [GO:0043066]; neurotrophin TRK receptor signaling pathway [GO:0048011]; organ regeneration [GO:0031100]; organelle organization [GO:0006996]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of DNA replication [GO:0045740]; positive regulation of gene expression [GO:0010628]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of protein import into nucleus, translocation [GO:0033160]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; pronuclear fusion [GO:0007344]; protein complex assembly [GO:0006461]; protein localization to kinetochore [GO:0034501]; Ras protein signal transduction [GO:0007265]; regulation of embryonic development [GO:0045995]; regulation of Schwann cell differentiation [GO:0014038]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; response to activity [GO:0014823]; response to amine [GO:0014075]; response to axon injury [GO:0048678]; response to cadmium ion [GO:0046686]; response to copper ion [GO:0046688]; response to drug [GO:0042493]; response to ethanol [GO:0045471]; response to organic cyclic compound [GO:0014070]; response to toxic substance [GO:0009636]; small GTPase mediated signal transduction [GO:0007264]; stress-activated MAPK cascade [GO:0051403]; toll-like receptor 10 signaling pathway [GO:0034166]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 5 signaling pathway [GO:0034146]; toll-like receptor 9 signaling pathway [GO:0034162]; toll-like receptor signaling pathway [GO:0002224]; toll-like receptor TLR1:TLR2 signaling pathway [GO:0038123]; toll-like receptor TLR6:TLR2 signaling pathway [GO:0038124]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; ventricular cardiac muscle cell development [GO:0055015]	activation of MAPK activity [GO:0000187]; activation of MAPKK activity [GO:0000186]; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; apoptotic process [GO:0006915]; axon guidance [GO:0007411]; cell aging [GO:0007569]; cell division [GO:0051301]; cell migration [GO:0016477]; cellular response to hydrogen peroxide [GO:0070301]; centrosome cycle [GO:0007098]; chromosome condensation [GO:0030261]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; epidermal growth factor receptor signaling pathway [GO:0007173]; epithelial cell differentiation [GO:0030855]; Fc-epsilon receptor signaling pathway [GO:0038095]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; innate immune response [GO:0045087]; insulin receptor signaling pathway [GO:0008286]; MAPK cascade [GO:0000165]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle [GO:0000278]; mitotic G2 DNA damage checkpoint [GO:0007095]; mitotic nuclear division [GO:0007067]; mitotic nuclear envelope disassembly [GO:0007077]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; MyD88-independent toll-like receptor signaling pathway [GO:0002756]; negative regulation of apoptotic process [GO:0043066]; neurotrophin TRK receptor signaling pathway [GO:0048011]; organelle organization [GO:0006996]; organ regeneration [GO:0031100]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of DNA replication [GO:0045740]; positive regulation of gene expression [GO:0010628]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of protein import into nucleus, translocation [GO:0033160]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; pronuclear fusion [GO:0007344]; protein complex assembly [GO:0006461]; protein localization to kinetochore [GO:0034501]; Ras protein signal transduction [GO:0007265]; regulation of embryonic development [GO:0045995]; regulation of Schwann cell differentiation [GO:0014038]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; response to activity [GO:0014823]; response to amine [GO:0014075]; response to axon injury [GO:0048678]; response to cadmium ion [GO:0046686]; response to copper ion [GO:0046688]; response to drug [GO:0042493]; response to ethanol [GO:0045471]; response to organic cyclic compound [GO:0014070]; response to toxic substance [GO:0009636]; small GTPase mediated signal transduction [GO:0007264]; stress-activated MAPK cascade [GO:0051403]; toll-like receptor 10 signaling pathway [GO:0034166]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 5 signaling pathway [GO:0034146]; toll-like receptor 9 signaling pathway [GO:0034162]; toll-like receptor signaling pathway [GO:0002224]; toll-like receptor TLR1:TLR2 signaling pathway [GO:0038123]; toll-like receptor TLR6:TLR2 signaling pathway [GO:0038124]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; ventricular cardiac muscle cell development [GO:0055015]	ATP binding [GO:0005524]; cyclin-dependent protein serine/threonine kinase activity [GO:0004693]; histone kinase activity [GO:0035173]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; RNA polymerase II carboxy-terminal domain kinase activity [GO:0008353]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; midbody [GO:0030496]; mitochondrion [GO:0005739]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle microtubule [GO:0005876]	GO:0005524; GO:0006281; GO:0006260; GO:0038095; GO:0000082; GO:0000086; GO:0000165; GO:0002755; GO:0002756; GO:0008353; GO:0007265; GO:0035666; GO:0000187; GO:0000186; GO:0031145; GO:0006915; GO:0007411; GO:0007569; GO:0051301; GO:0016477; GO:0070301; GO:0005813; GO:0007098; GO:0030261; GO:0004693; GO:0005737; GO:0005829; GO:0007173; GO:0030855; GO:0070062; GO:0008543; GO:0035173; GO:0045087; GO:0008286; GO:0016020; GO:0000226; GO:0030496; GO:0005739; GO:0007095; GO:0000278; GO:0007067; GO:0007077; GO:0072686; GO:0043066; GO:0048011; GO:0005654; GO:0005634; GO:0031100; GO:0006996; GO:0018105; GO:0018107; GO:0045740; GO:0060045; GO:0010628; GO:0045931; GO:0033160; GO:0051437; GO:0007344; GO:0006461; GO:0004672; GO:0034501; GO:0004674; GO:0014038; GO:0045995; GO:0000083; GO:0051439; GO:0014823; GO:0014075; GO:0048678; GO:0046686; GO:0046688; GO:0042493; GO:0045471; GO:0014070; GO:0009636; GO:0007264; GO:0005876; GO:0051403; GO:0034166; GO:0034134; GO:0034138; GO:0034142; GO:0034146; GO:0034162; GO:0038123; GO:0038124; GO:0002224; GO:0048010; GO:0055015	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Mitochondrion. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Cytoplasmic during the interphase. Colocalizes with SIRT2 on centrosome during prophase and on splindle fibers during metaphase of the mitotic cell cycle. Reversibly translocated from cytoplasm to nucleus when phosphorylated before G2-M transition when associated with cyclin-B1. Accumulates in mitochondria in G2-arrested cells upon DNA-damage.	3D-structure; ATP-binding; Acetylation; Alternative splicing; Apoptosis; Cell cycle; Cell division; Complete proteome; Cytoplasm; Cytoskeleton; Isopeptide bond; Kinase; Mitochondrion; Mitosis; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Ubl conjugation	Active site (1); Alternative sequence (1); Binding site (1); Chain (1); Cross-link (1); Domain (1); Erroneous gene model prediction (1); Modified residue (14); Mutagenesis (2); Nucleotide binding (1)
FA96A_HUMAN	Q9H5X1	FA96A_HUMAN	reviewed	MIP18 family protein FAM96A	FAM96A	Homo sapiens (Human)	160	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; metal ion binding [GO:0046872]; chromosome segregation [GO:0007059]; iron-sulfur cluster assembly [GO:0016226]	chromosome segregation [GO:0007059]; iron-sulfur cluster assembly [GO:0016226]	metal ion binding [GO:0046872]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]	GO:0007059; GO:0005737; GO:0016226; GO:0046872; GO:0005654	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22683786}.	3D-structure; Alternative splicing; Chromosome partition; Complete proteome; Cytoplasm; Metal-binding; Reference proteome; Zinc	Alternative sequence (1); Beta strand (6); Chain (1); Helix (6); Metal binding (8); Turn (1)
E9PNX9_HUMAN	E9PNX9	E9PNX9_HUMAN	unreviewed	Leupaxin	LPXN	Homo sapiens (Human)	106							Complete proteome; Proteomics identification; Reference proteome	
UBE4B_HUMAN	O95155	UBE4B_HUMAN	reviewed	Ubiquitin conjugation factor E4 B (EC 6.3.2.-) (Homozygously deleted in neuroblastoma 1) (Ubiquitin fusion degradation protein 2)	UBE4B HDNB1 KIAA0684 UFD2	Homo sapiens (Human)	1302	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; enzyme binding [GO:0019899]; ligase activity [GO:0016874]; ubiquitin-ubiquitin ligase activity [GO:0034450]; granzyme-mediated apoptotic signaling pathway [GO:0008626]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; response to UV [GO:0009411]	granzyme-mediated apoptotic signaling pathway [GO:0008626]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; response to UV [GO:0009411]	enzyme binding [GO:0019899]; ligase activity [GO:0016874]; ubiquitin-ubiquitin ligase activity [GO:0034450]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	GO:0005737; GO:0019899; GO:0008626; GO:0016874; GO:0005634; GO:0043161; GO:0042787; GO:0009411; GO:0000151; GO:0034450	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9ES00}. Nucleus {ECO:0000250|UniProtKB:Q9ES00}.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Ligase; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation pathway	Alternative sequence (4); Beta strand (2); Chain (1); Domain (1); Erroneous initiation (1); Helix (4); Modified residue (9); Mutagenesis (3); Natural variant (1); Site (2); Turn (3)
G3V0J0_HUMAN	G3V0J0	G3V0J0_HUMAN	unreviewed	Fragile X mental retardation 1, isoform CRA_e (Fragile X mental retardation protein 1)	FMR1 hCG_18633	Homo sapiens (Human)	592	cytoplasm [GO:0005737]; nucleus [GO:0005634]; polysome [GO:0005844]; RNA binding [GO:0003723]; negative regulation of translation [GO:0017148]	negative regulation of translation [GO:0017148]	RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nucleus [GO:0005634]; polysome [GO:0005844]	GO:0003723; GO:0005737; GO:0017148; GO:0005634; GO:0005844		Complete proteome; Proteomics identification; Reference proteome	
CPZIP_HUMAN	Q6JBY9	CPZIP_HUMAN	reviewed	CapZ-interacting protein (Protein kinase substrate CapZIP) (RCSD domain-containing protein 1)	RCSD1 CAPZIP	Homo sapiens (Human)	416	actin filament [GO:0005884]; actin filament binding [GO:0051015]; cellular hyperosmotic response [GO:0071474]; skeletal muscle contraction [GO:0003009]	cellular hyperosmotic response [GO:0071474]; skeletal muscle contraction [GO:0003009]	actin filament binding [GO:0051015]	actin filament [GO:0005884]	GO:0005884; GO:0051015; GO:0071474; GO:0003009		Alternative splicing; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome	Alternative sequence (1); Chain (1); Domain (1); Erroneous initiation (1); Modified residue (17); Natural variant (1); Sequence conflict (3)
BCD1_HUMAN	Q9NWK9	BCD1_HUMAN	reviewed	Box C/D snoRNA protein 1 (Serologically defined breast cancer antigen NY-BR-75) (Zinc finger HIT domain-containing protein 6)	ZNHIT6 BCD1 C1orf181	Homo sapiens (Human)	470	extracellular exosome [GO:0070062]; pre-snoRNP complex [GO:0070761]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; box C/D snoRNP assembly [GO:0000492]; ribosome biogenesis [GO:0042254]	box C/D snoRNP assembly [GO:0000492]; ribosome biogenesis [GO:0042254]	enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]	extracellular exosome [GO:0070062]; pre-snoRNP complex [GO:0070761]	GO:0000492; GO:0019899; GO:0070062; GO:0042802; GO:0046872; GO:0070761; GO:0042254		Alternative splicing; Complete proteome; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Ribosome biogenesis; Zinc; Zinc-finger	Alternative sequence (1); Chain (1); Compositional bias (1); Erroneous initiation (1); Frameshift (1); Modified residue (1); Natural variant (2); Sequence conflict (1); Zinc finger (1)
MTMR9_HUMAN	Q96QG7	MTMR9_HUMAN	reviewed	Myotubularin-related protein 9	MTMR9 C8orf9 MTMR8	Homo sapiens (Human)	549	cytoplasm [GO:0005737]; enzyme regulator activity [GO:0030234]		enzyme regulator activity [GO:0030234]	cytoplasm [GO:0005737]	GO:0005737; GO:0030234	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16787938}.	Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome	Alternative sequence (1); Chain (1); Domain (1); Modified residue (2); Sequence conflict (2)
UBA6_HUMAN	A0AVT1	UBA6_HUMAN	reviewed	Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (Monocyte protein 4) (MOP-4) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2)	UBA6 MOP4 UBE1L2	Homo sapiens (Human)	1052	cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; FAT10 activating enzyme activity [GO:0019780]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]	ATP binding [GO:0005524]; FAT10 activating enzyme activity [GO:0019780]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0005524; GO:0019780; GO:0005737; GO:0005829; GO:0016567; GO:0006511		ATP-binding; Acetylation; Alternative splicing; Complete proteome; Ligase; Nucleotide-binding; Polymorphism; Reference proteome; Ubl conjugation pathway	Active site (1); Alternative sequence (5); Chain (1); Erroneous initiation (1); Modified residue (3); Mutagenesis (1); Natural variant (1); Nucleotide binding (1); Sequence conflict (12)
CRLF3_HUMAN	Q8IUI8	CRLF3_HUMAN	reviewed	Cytokine receptor-like factor 3 (Cytokine receptor-like molecule 9) (CREME-9) (Cytokine receptor-related protein 4) (Type I cytokine receptor-like factor p48)	CRLF3 CREME9 CRLM9 CYTOR4 P48	Homo sapiens (Human)	442	cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of cell growth [GO:0030308]; positive regulation of cell cycle arrest [GO:0071158]; positive regulation of JAK-STAT cascade [GO:0046427]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]	G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of cell growth [GO:0030308]; positive regulation of cell cycle arrest [GO:0071158]; positive regulation of JAK-STAT cascade [GO:0046427]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]		cytoplasm [GO:0005737]; plasma membrane [GO:0005886]	GO:0000082; GO:0005737; GO:0030308; GO:0005886; GO:0046427; GO:0071158; GO:0045944; GO:0045893	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19427400}. Note=The EGFP- and MYC-tagged protein has been shown to be cytoplasmic. {ECO:0000269|PubMed:19427400}.	Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Polymorphism; Reference proteome	Alternative sequence (1); Chain (1); Coiled coil (1); Domain (1); Natural variant (2); Sequence conflict (3)
TYDP2_HUMAN	O95551	TYDP2_HUMAN	reviewed	Tyrosyl-DNA phosphodiesterase 2 (Tyr-DNA phosphodiesterase 2) (hTDP2) (EC 3.1.4.-) (5'-tyrosyl-DNA phosphodiesterase) (5'-Tyr-DNA phosphodiesterase) (ETS1-associated protein 2) (ETS1-associated protein II) (EAPII) (TRAF and TNF receptor-associated protein) (Tyrosyl-RNA phosphodiesterase) (VPg unlinkase)	TDP2 EAP2 TTRAP AD-022	Homo sapiens (Human)	362	cytoplasm [GO:0005737]; intercellular bridge [GO:0045171]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; 5'-tyrosyl-DNA phosphodiesterase activity [GO:0070260]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; nuclease activity [GO:0004518]; single-stranded DNA binding [GO:0003697]; transcription corepressor activity [GO:0003714]; tyrosyl-RNA phosphodiesterase activity [GO:0036317]; cell surface receptor signaling pathway [GO:0007166]; double-strand break repair [GO:0006302]; negative regulation of nucleic acid-templated transcription [GO:1903507]	cell surface receptor signaling pathway [GO:0007166]; double-strand break repair [GO:0006302]; negative regulation of nucleic acid-templated transcription [GO:1903507]	5'-tyrosyl-DNA phosphodiesterase activity [GO:0070260]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; nuclease activity [GO:0004518]; single-stranded DNA binding [GO:0003697]; transcription corepressor activity [GO:0003714]; tyrosyl-RNA phosphodiesterase activity [GO:0036317]	cytoplasm [GO:0005737]; intercellular bridge [GO:0045171]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	GO:0070260; GO:0016605; GO:0007166; GO:0005737; GO:0006302; GO:0045171; GO:0000287; GO:0030145; GO:1903507; GO:0004518; GO:0005730; GO:0005654; GO:0005634; GO:0003697; GO:0003714; GO:0036317	SUBCELLULAR LOCATION: Nucleus. Nucleus, PML body. Nucleus, nucleolus. Cytoplasm. Note=Localizes to nucleolar cavities following stress; localization to nucleolus is dependent on PML protein. In case of infection by picornavirus, relocalizes to cytoplasmic sites distinct from those containing viral proteins associated with RNA replication or encapsidation.	Acetylation; Alternative splicing; Complete proteome; Cytoplasm; DNA damage; DNA repair; Hydrolase; Magnesium; Metal-binding; Nuclease; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation	Active site (1); Alternative sequence (2); Chain (1); Erroneous gene model prediction (1); Erroneous initiation (1); Metal binding (6); Modified residue (3); Mutagenesis (6); Natural variant (3); Sequence conflict (3)
IMB1_HUMAN	Q14974	IMB1_HUMAN	reviewed	Importin subunit beta-1 (Importin-90) (Karyopherin subunit beta-1) (Nuclear factor p97) (Pore targeting complex 97 kDa subunit) (PTAC97)	KPNB1 NTF97	Homo sapiens (Human)	876	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum tubular network [GO:0071782]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; enzyme binding [GO:0019899]; nuclear localization sequence binding [GO:0008139]; poly(A) RNA binding [GO:0044822]; protein domain specific binding [GO:0019904]; protein transporter activity [GO:0008565]; zinc ion binding [GO:0008270]; apoptotic DNA fragmentation [GO:0006309]; apoptotic process [GO:0006915]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; cytokine-mediated signaling pathway [GO:0019221]; intracellular transport of virus [GO:0075733]; NLS-bearing protein import into nucleus [GO:0006607]; programmed cell death [GO:0012501]; protein import into nucleus [GO:0006606]; protein import into nucleus, translocation [GO:0000060]; ribosomal protein import into nucleus [GO:0006610]; small molecule metabolic process [GO:0044281]; viral life cycle [GO:0019058]; viral process [GO:0016032]	apoptotic DNA fragmentation [GO:0006309]; apoptotic process [GO:0006915]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; cytokine-mediated signaling pathway [GO:0019221]; intracellular transport of virus [GO:0075733]; NLS-bearing protein import into nucleus [GO:0006607]; programmed cell death [GO:0012501]; protein import into nucleus [GO:0006606]; protein import into nucleus, translocation [GO:0000060]; ribosomal protein import into nucleus [GO:0006610]; small molecule metabolic process [GO:0044281]; viral life cycle [GO:0019058]; viral process [GO:0016032]	enzyme binding [GO:0019899]; nuclear localization sequence binding [GO:0008139]; poly(A) RNA binding [GO:0044822]; protein domain specific binding [GO:0019904]; protein transporter activity [GO:0008565]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum tubular network [GO:0071782]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]	GO:0006607; GO:0006309; GO:0006915; GO:0006921; GO:0019221; GO:0005737; GO:0005829; GO:0071782; GO:0019899; GO:0070062; GO:0075733; GO:0016020; GO:0005635; GO:0008139; GO:0031965; GO:0005643; GO:0005654; GO:0044822; GO:0012501; GO:0019904; GO:0006606; GO:0000060; GO:0008565; GO:0006610; GO:0044281; GO:0019058; GO:0016032; GO:0008270	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11891849}. Nucleus envelope {ECO:0000269|PubMed:11891849}.	3D-structure; ADP-ribosylation; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Host-virus interaction; Isopeptide bond; Nucleus; Phosphoprotein; Protein transport; Reference proteome; Repeat; Transport; Ubl conjugation	Alternative sequence (1); Beta strand (10); Chain (1); Compositional bias (1); Cross-link (2); Domain (1); Helix (56); Modified residue (5); Mutagenesis (2); Region (2); Repeat (19); Sequence conflict (3); Turn (10)
B0QXZ6_HUMAN	B0QXZ6	B0QXZ6_HUMAN	unreviewed	Chromobox protein homolog 6	CBX6	Homo sapiens (Human)	394	nucleus [GO:0005634]			nucleus [GO:0005634]	GO:0005634		Complete proteome; Nucleus; Proteomics identification; Reference proteome	
C9JXR7_HUMAN	C9JXR7	C9JXR7_HUMAN	unreviewed	Caspase-3 (Fragment)	CASP3	Homo sapiens (Human)	117	cytoplasm [GO:0005737]; cysteine-type endopeptidase activity [GO:0004197]; apoptotic process [GO:0006915]; keratinocyte differentiation [GO:0030216]; neuron differentiation [GO:0030182]	apoptotic process [GO:0006915]; keratinocyte differentiation [GO:0030216]; neuron differentiation [GO:0030182]	cysteine-type endopeptidase activity [GO:0004197]	cytoplasm [GO:0005737]	GO:0006915; GO:0004197; GO:0005737; GO:0030216; GO:0030182		Complete proteome; Proteomics identification; Reference proteome	Non-terminal residue (1)
A8MVM1_HUMAN	A8MVM1	A8MVM1_HUMAN	unreviewed	Caspase-3	CASP3	Homo sapiens (Human)	182	cytoplasm [GO:0005737]; cysteine-type endopeptidase activity [GO:0004197]; apoptotic process [GO:0006915]; keratinocyte differentiation [GO:0030216]; neuron differentiation [GO:0030182]	apoptotic process [GO:0006915]; keratinocyte differentiation [GO:0030216]; neuron differentiation [GO:0030182]	cysteine-type endopeptidase activity [GO:0004197]	cytoplasm [GO:0005737]	GO:0006915; GO:0004197; GO:0005737; GO:0030216; GO:0030182		Complete proteome; Proteomics identification; Reference proteome	
MSS4_HUMAN	P47224	MSS4_HUMAN	reviewed	Guanine nucleotide exchange factor MSS4 (Rab-interacting factor)	RABIF MSS4 RASGRF3	Homo sapiens (Human)	123	intracellular [GO:0005622]; guanyl-nucleotide exchange factor activity [GO:0005085]; zinc ion binding [GO:0008270]; membrane fusion [GO:0061025]; positive regulation of GTPase activity [GO:0043547]; protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264]	membrane fusion [GO:0061025]; positive regulation of GTPase activity [GO:0043547]; protein transport [GO:0015031]; small GTPase mediated signal transduction [GO:0007264]	guanyl-nucleotide exchange factor activity [GO:0005085]; zinc ion binding [GO:0008270]	intracellular [GO:0005622]	GO:0005085; GO:0005622; GO:0061025; GO:0043547; GO:0015031; GO:0007264; GO:0008270		3D-structure; Acetylation; Complete proteome; Guanine-nucleotide releasing factor; Metal-binding; Protein transport; Reference proteome; Transport; Zinc	Beta strand (11); Chain (1); Helix (2); Metal binding (4); Modified residue (1); Sequence conflict (1); Turn (2)
RPB9_HUMAN	P36954	RPB9_HUMAN	reviewed	DNA-directed RNA polymerase II subunit RPB9 (RNA polymerase II subunit B9) (DNA-directed RNA polymerase II subunit I) (RNA polymerase II 14.5 kDa subunit) (RPB14.5)	POLR2I	Homo sapiens (Human)	125	DNA-directed RNA polymerase II, core complex [GO:0005665]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-directed RNA polymerase activity [GO:0003899]; zinc ion binding [GO:0008270]; 7-methylguanosine mRNA capping [GO:0006370]; DNA repair [GO:0006281]; gene expression [GO:0010467]; maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter [GO:0001193]; mRNA splicing, via spliceosome [GO:0000398]; nucleotide-excision repair [GO:0006289]; piRNA metabolic process [GO:0034587]; positive regulation of viral transcription [GO:0050434]; RNA splicing [GO:0008380]; somatic stem cell maintenance [GO:0035019]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]; transcription-coupled nucleotide-excision repair [GO:0006283]; viral process [GO:0016032]	7-methylguanosine mRNA capping [GO:0006370]; DNA repair [GO:0006281]; gene expression [GO:0010467]; maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter [GO:0001193]; mRNA splicing, via spliceosome [GO:0000398]; nucleotide-excision repair [GO:0006289]; piRNA metabolic process [GO:0034587]; positive regulation of viral transcription [GO:0050434]; RNA splicing [GO:0008380]; somatic stem cell maintenance [GO:0035019]; transcription-coupled nucleotide-excision repair [GO:0006283]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription from RNA polymerase II promoter [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]; viral process [GO:0016032]	DNA binding [GO:0003677]; DNA-directed RNA polymerase activity [GO:0003899]; zinc ion binding [GO:0008270]	DNA-directed RNA polymerase II, core complex [GO:0005665]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0006370; GO:0003677; GO:0006281; GO:0005665; GO:0003899; GO:0008380; GO:0010467; GO:0000398; GO:0001193; GO:0005730; GO:0005654; GO:0006289; GO:0005634; GO:0034587; GO:0050434; GO:0035019; GO:0006368; GO:0006366; GO:0006367; GO:0006283; GO:0016032; GO:0008270	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:9852112}.	Acetylation; Complete proteome; DNA-directed RNA polymerase; Metal-binding; Nucleus; Reference proteome; Transcription; Zinc; Zinc-finger	Chain (1); Metal binding (8); Modified residue (1); Zinc finger (2)
K7EKS1_HUMAN	K7EKS1	K7EKS1_HUMAN	unreviewed	DNA-directed RNA polymerase II subunit RPB9	POLR2I	Homo sapiens (Human)	88	nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; DNA-directed RNA polymerase activity [GO:0003899]; maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter [GO:0001193]; transcription initiation from RNA polymerase II promoter [GO:0006367]; transcription-coupled nucleotide-excision repair [GO:0006283]	maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter [GO:0001193]; transcription-coupled nucleotide-excision repair [GO:0006283]; transcription initiation from RNA polymerase II promoter [GO:0006367]	DNA binding [GO:0003677]; DNA-directed RNA polymerase activity [GO:0003899]	nucleoplasm [GO:0005654]	GO:0003677; GO:0003899; GO:0001193; GO:0005654; GO:0006367; GO:0006283		Complete proteome; Proteomics identification; Reference proteome	
GGA1_HUMAN	Q9UJY5	GGA1_HUMAN	reviewed	ADP-ribosylation factor-binding protein GGA1 (Gamma-adaptin-related protein 1) (Golgi-localized, gamma ear-containing, ARF-binding protein 1)	GGA1	Homo sapiens (Human)	639	clathrin adaptor complex [GO:0030131]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; intracellular protein transport [GO:0006886]; positive regulation of protein catabolic process [GO:0045732]; vesicle-mediated transport [GO:0016192]	intracellular protein transport [GO:0006886]; positive regulation of protein catabolic process [GO:0045732]; vesicle-mediated transport [GO:0016192]		clathrin adaptor complex [GO:0030131]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]	GO:0005794; GO:0030131; GO:0010008; GO:0043231; GO:0006886; GO:0016020; GO:0005654; GO:0045732; GO:0016192	SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Endosome; Golgi apparatus; Membrane; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport; Ubl conjugation	Alternative sequence (6); Beta strand (10); Chain (1); Domain (3); Helix (19); Modified residue (3); Motif (1); Mutagenesis (25); Natural variant (2); Region (2); Turn (3)
E9PEZ3_HUMAN	E9PEZ3	E9PEZ3_HUMAN		Deleted.											
STIP1_HUMAN	P31948	STIP1_HUMAN	reviewed	Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521)	STIP1	Homo sapiens (Human)	543	Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; poly(A) RNA binding [GO:0044822]; response to stress [GO:0006950]	response to stress [GO:0006950]	poly(A) RNA binding [GO:0044822]	Golgi apparatus [GO:0005794]; nucleus [GO:0005634]	GO:0005794; GO:0005634; GO:0044822; GO:0006950	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome; Repeat; TPR repeat	Alternative sequence (2); Chain (1); Domain (2); Helix (22); Modified residue (11); Motif (1); Repeat (9); Sequence conflict (3); Turn (1)
IPO4_HUMAN	Q8TEX9	IPO4_HUMAN	reviewed	Importin-4 (Imp4) (Importin-4b) (Imp4b) (Ran-binding protein 4) (RanBP4)	IPO4 IMP4B RANBP4	Homo sapiens (Human)	1081	cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear chromatin [GO:0000790]; protein complex [GO:0043234]; DNA replication-dependent nucleosome assembly [GO:0006335]; DNA replication-independent nucleosome assembly [GO:0006336]; intracellular protein transport [GO:0006886]; protein transport [GO:0015031]	DNA replication-dependent nucleosome assembly [GO:0006335]; DNA replication-independent nucleosome assembly [GO:0006336]; intracellular protein transport [GO:0006886]; protein transport [GO:0015031]		cytoplasm [GO:0005737]; membrane [GO:0016020]; nuclear chromatin [GO:0000790]; protein complex [GO:0043234]	GO:0006335; GO:0006336; GO:0005737; GO:0006886; GO:0016020; GO:0000790; GO:0043234; GO:0015031	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.	Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Polymorphism; Protein transport; Reference proteome; Repeat; Transport	Alternative sequence (1); Chain (1); Domain (1); Erroneous initiation (3); Frameshift (1); Modified residue (1); Natural variant (2); Repeat (6); Sequence conflict (2)
IF4G2_HUMAN	P78344	IF4G2_HUMAN	reviewed	Eukaryotic translation initiation factor 4 gamma 2 (eIF-4-gamma 2) (eIF-4G 2) (eIF4G 2) (Death-associated protein 5) (DAP-5) (p97)	EIF4G2 DAP5 OK/SW-cl.75	Homo sapiens (Human)	907	cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; membrane [GO:0016020]; poly(A) RNA binding [GO:0044822]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]; cell cycle arrest [GO:0007050]; cell death [GO:0008219]; cytokine-mediated signaling pathway [GO:0019221]; regulation of translational initiation [GO:0006446]	cell cycle arrest [GO:0007050]; cell death [GO:0008219]; cytokine-mediated signaling pathway [GO:0019221]; regulation of translational initiation [GO:0006446]	poly(A) RNA binding [GO:0044822]; translation factor activity, RNA binding [GO:0008135]; translation initiation factor activity [GO:0003743]	cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; membrane [GO:0016020]	GO:0007050; GO:0008219; GO:0019221; GO:0005829; GO:0016281; GO:0016020; GO:0044822; GO:0006446; GO:0008135; GO:0003743		3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Initiation factor; Phosphoprotein; Polymorphism; Protein biosynthesis; Reference proteome; Repressor; Translation regulation	Alternative sequence (1); Beta strand (2); Chain (1); Domain (3); Erroneous initiation (1); Helix (38); Modified residue (5); Natural variant (1); Sequence caution (2); Sequence conflict (10); Turn (6)
PNO1_HUMAN	Q9NRX1	PNO1_HUMAN	reviewed	RNA-binding protein PNO1	PNO1	Homo sapiens (Human)	252	nucleolus [GO:0005730]; nucleus [GO:0005634]; poly(A) RNA binding [GO:0044822]		poly(A) RNA binding [GO:0044822]	nucleolus [GO:0005730]; nucleus [GO:0005634]	GO:0005730; GO:0005634; GO:0044822	SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:15497447}.	Acetylation; Complete proteome; Nucleus; Polymorphism; RNA-binding; Reference proteome	Chain (1); Domain (1); Modified residue (1); Natural variant (2)
KAP0_HUMAN	P10644	KAP0_HUMAN	reviewed	cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1) (TSE1) [Cleaved into: cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed]	PRKAR1A PKR1 PRKAR1 TSE1	Homo sapiens (Human)	381	AMP-activated protein kinase complex [GO:0031588]; cAMP-dependent protein kinase complex [GO:0005952]; ciliary base [GO:0097546]; cytosol [GO:0005829]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; protein complex [GO:0043234]; cAMP binding [GO:0030552]; cAMP-dependent protein kinase inhibitor activity [GO:0004862]; cAMP-dependent protein kinase regulator activity [GO:0008603]; protein kinase A catalytic subunit binding [GO:0034236]; ubiquitin protein ligase binding [GO:0031625]; activation of phospholipase C activity [GO:0007202]; activation of protein kinase A activity [GO:0034199]; blood coagulation [GO:0007596]; cardiac muscle cell proliferation [GO:0060038]; cellular response to glucagon stimulus [GO:0071377]; energy reserve metabolic process [GO:0006112]; epidermal growth factor receptor signaling pathway [GO:0007173]; female meiotic division [GO:0007143]; fibroblast growth factor receptor signaling pathway [GO:0008543]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; mesoderm formation [GO:0001707]; negative regulation of cAMP-dependent protein kinase activity [GO:2000480]; negative regulation of meiotic nuclear division [GO:0045835]; neurotrophin TRK receptor signaling pathway [GO:0048011]; regulation of insulin secretion [GO:0050796]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; renal water homeostasis [GO:0003091]; sarcomere organization [GO:0045214]; signal transduction [GO:0007165]; small molecule metabolic process [GO:0044281]; transmembrane transport [GO:0055085]; water transport [GO:0006833]	activation of phospholipase C activity [GO:0007202]; activation of protein kinase A activity [GO:0034199]; blood coagulation [GO:0007596]; cardiac muscle cell proliferation [GO:0060038]; cellular response to glucagon stimulus [GO:0071377]; energy reserve metabolic process [GO:0006112]; epidermal growth factor receptor signaling pathway [GO:0007173]; female meiotic division [GO:0007143]; fibroblast growth factor receptor signaling pathway [GO:0008543]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; mesoderm formation [GO:0001707]; negative regulation of cAMP-dependent protein kinase activity [GO:2000480]; negative regulation of meiotic nuclear division [GO:0045835]; neurotrophin TRK receptor signaling pathway [GO:0048011]; regulation of insulin secretion [GO:0050796]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; renal water homeostasis [GO:0003091]; sarcomere organization [GO:0045214]; signal transduction [GO:0007165]; small molecule metabolic process [GO:0044281]; transmembrane transport [GO:0055085]; water transport [GO:0006833]	cAMP binding [GO:0030552]; cAMP-dependent protein kinase inhibitor activity [GO:0004862]; cAMP-dependent protein kinase regulator activity [GO:0008603]; protein kinase A catalytic subunit binding [GO:0034236]; ubiquitin protein ligase binding [GO:0031625]	AMP-activated protein kinase complex [GO:0031588]; cAMP-dependent protein kinase complex [GO:0005952]; ciliary base [GO:0097546]; cytosol [GO:0005829]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; protein complex [GO:0043234]	GO:0031588; GO:0007202; GO:0034199; GO:0007596; GO:0030552; GO:0005952; GO:0004862; GO:0008603; GO:0060038; GO:0071377; GO:0097546; GO:0005829; GO:0006112; GO:0007173; GO:0007143; GO:0008543; GO:0045087; GO:0035556; GO:0016020; GO:0001707; GO:2000480; GO:0045835; GO:0031594; GO:0048011; GO:0005886; GO:0043234; GO:0034236; GO:0050796; GO:0006357; GO:0003091; GO:0045214; GO:0007165; GO:0044281; GO:0055085; GO:0031625; GO:0006833	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23115245}.	Acetylation; Alternative splicing; Cell membrane; Complete proteome; Cushing syndrome; Direct protein sequencing; Disease mutation; Disulfide bond; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; cAMP; cAMP-binding	Alternative sequence (2); Binding site (4); Chain (2); Disulfide bond (2); Initiator methionine (1); Modified residue (5); Motif (1); Mutagenesis (1); Natural variant (17); Nucleotide binding (2); Region (1)
D6REE2_HUMAN	D6REE2	D6REE2_HUMAN	unreviewed	DTW domain-containing protein 2	DTWD2	Homo sapiens (Human)	137							Complete proteome; Proteomics identification; Reference proteome	
DFFA_HUMAN	O00273	DFFA_HUMAN	reviewed	DNA fragmentation factor subunit alpha (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) (ICAD)	DFFA DFF1 DFF45 H13	Homo sapiens (Human)	331	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear chromatin [GO:0000790]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; apoptotic DNA fragmentation [GO:0006309]; apoptotic process [GO:0006915]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; negative regulation of apoptotic DNA fragmentation [GO:1902511]; negative regulation of execution phase of apoptosis [GO:1900118]; positive regulation of apoptotic process [GO:0043065]; programmed cell death [GO:0012501]; thymocyte apoptotic process [GO:0070242]	apoptotic DNA fragmentation [GO:0006309]; apoptotic process [GO:0006915]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; negative regulation of apoptotic DNA fragmentation [GO:1902511]; negative regulation of execution phase of apoptosis [GO:1900118]; positive regulation of apoptotic process [GO:0043065]; programmed cell death [GO:0012501]; thymocyte apoptotic process [GO:0070242]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear chromatin [GO:0000790]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0006309; GO:0006915; GO:0006921; GO:0005737; GO:0005829; GO:1902511; GO:1900118; GO:0000790; GO:0005654; GO:0005634; GO:0043065; GO:0012501; GO:0070242	SUBCELLULAR LOCATION: Cytoplasm.	3D-structure; Acetylation; Alternative splicing; Apoptosis; Complete proteome; Cytoplasm; Direct protein sequencing; Phosphoprotein; Reference proteome	Alternative sequence (2); Beta strand (2); Chain (1); Domain (1); Helix (7); Modified residue (2); Sequence conflict (1); Site (2); Turn (2)
PSB2_HUMAN	P49721	PSB2_HUMAN	reviewed	Proteasome subunit beta type-2 (EC 3.4.25.1) (Macropain subunit C7-I) (Multicatalytic endopeptidase complex subunit C7-I) (Proteasome component C7-I)	PSMB2	Homo sapiens (Human)	201	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298]; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; response to organic cyclic compound [GO:0014070]; response to organonitrogen compound [GO:0010243]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; response to organic cyclic compound [GO:0014070]; response to organonitrogen compound [GO:0010243]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]	GO:0006977; GO:0000082; GO:0031145; GO:0042590; GO:0002479; GO:0002474; GO:0006915; GO:0034641; GO:0005737; GO:0005829; GO:0004175; GO:0070062; GO:0010467; GO:0045087; GO:0016020; GO:0000278; GO:0043066; GO:0090090; GO:0051436; GO:0005654; GO:0005634; GO:0090263; GO:0051437; GO:0012501; GO:0010499; GO:0000502; GO:0005839; GO:0043161; GO:0000209; GO:0042981; GO:0006521; GO:0051439; GO:0014070; GO:0010243; GO:0044281; GO:0002223; GO:0004298; GO:0016032	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Host-virus interaction; Hydrolase; Nucleus; Protease; Proteasome; Reference proteome; Threonine protease	Beta strand (14); Chain (1); Helix (4); Modified residue (1); Turn (2)
PSF1_HUMAN	Q14691	PSF1_HUMAN	reviewed	DNA replication complex GINS protein PSF1 (GINS complex subunit 1)	GINS1 KIAA0186 PSF1	Homo sapiens (Human)	196	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA strand elongation involved in DNA replication [GO:0006271]; inner cell mass cell proliferation [GO:0001833]; mitotic cell cycle [GO:0000278]	DNA strand elongation involved in DNA replication [GO:0006271]; inner cell mass cell proliferation [GO:0001833]; mitotic cell cycle [GO:0000278]		cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0006271; GO:0005737; GO:0001833; GO:0000278; GO:0005654; GO:0005634	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.	3D-structure; Complete proteome; DNA replication; Nucleus; Polymorphism; Reference proteome	Beta strand (2); Chain (1); Erroneous initiation (1); Helix (6); Mass spectrometry (1); Natural variant (1)
E9PPG8_HUMAN	E9PPG8	E9PPG8_HUMAN	unreviewed	Protein Hikeshi	C11orf73	Homo sapiens (Human)	194	cell junction [GO:0030054]; nucleus [GO:0005634]			cell junction [GO:0030054]; nucleus [GO:0005634]	GO:0030054; GO:0005634		Complete proteome; Proteomics identification; Reference proteome	
C9J8Z7_HUMAN	C9J8Z7	C9J8Z7_HUMAN	unreviewed	DNA polymerase delta subunit 2 (Fragment)	POLD2	Homo sapiens (Human)	155							Complete proteome; Proteomics identification; Reference proteome	Non-terminal residue (1)
C9IZD2_HUMAN	C9IZD2	C9IZD2_HUMAN	unreviewed	DNA polymerase delta subunit 2 (Fragment)	POLD2	Homo sapiens (Human)	148							Complete proteome; Proteomics identification; Reference proteome	Non-terminal residue (1)
NUDC_HUMAN	Q9Y266	NUDC_HUMAN	reviewed	Nuclear migration protein nudC (Nuclear distribution protein C homolog)	NUDC	Homo sapiens (Human)	331	cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]; cell division [GO:0051301]; cell proliferation [GO:0008283]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; multicellular organismal development [GO:0007275]; small GTPase mediated signal transduction [GO:0007264]	cell division [GO:0051301]; cell proliferation [GO:0008283]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; multicellular organismal development [GO:0007275]; small GTPase mediated signal transduction [GO:0007264]		cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule [GO:0005874]; nucleoplasm [GO:0005654]	GO:0051301; GO:0008283; GO:0005737; GO:0005829; GO:0005874; GO:0000278; GO:0007067; GO:0007275; GO:0005654; GO:0007264	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Nucleus. Note=In a filamentous pattern adjacent to the nucleus of migrating cerebellar granule cells. Colocalizes with tubulin and dynein and with the microtubule organizing center. Distributed throughout the cytoplasm of non-migrating cells. A small proportion is nuclear, in a punctate pattern.	3D-structure; Acetylation; Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Mitosis; Nucleus; Phosphoprotein; Reference proteome	Beta strand (7); Chain (1); Coiled coil (1); Domain (1); Erroneous gene model prediction (2); Frameshift (1); Helix (3); Modified residue (6); Motif (1); Mutagenesis (2); Sequence conflict (8); Turn (1)
LC7L3_HUMAN	O95232	LC7L3_HUMAN	reviewed	Luc7-like protein 3 (Cisplatin resistance-associated-overexpressed protein) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18) (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1)	LUC7L3 CREAP1 CROP O48	Homo sapiens (Human)	432	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U1 snRNP [GO:0005685]; DNA binding [GO:0003677]; mRNA binding [GO:0003729]; poly(A) RNA binding [GO:0044822]; mRNA splice site selection [GO:0006376]; RNA splicing [GO:0008380]	mRNA splice site selection [GO:0006376]; RNA splicing [GO:0008380]	DNA binding [GO:0003677]; mRNA binding [GO:0003729]; poly(A) RNA binding [GO:0044822]	nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U1 snRNP [GO:0005685]	GO:0003677; GO:0008380; GO:0005685; GO:0003729; GO:0006376; GO:0016607; GO:0005654; GO:0005634; GO:0044822	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:10631324, ECO:0000269|PubMed:12565863}. Note=The subnuclear localization is affected by cisplatin.	Acetylation; Alternative splicing; Coiled coil; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; mRNA processing; mRNA splicing	Alternative sequence (2); Chain (1); Coiled coil (1); Compositional bias (2); Erroneous translation (1); Modified residue (7); Sequence conflict (2)
F5H423_HUMAN	F5H423	F5H423_HUMAN	unreviewed	Uncharacterized protein		Homo sapiens (Human)	210	intracellular [GO:0005622]; GTP binding [GO:0005525]; small GTPase mediated signal transduction [GO:0007264]	small GTPase mediated signal transduction [GO:0007264]	GTP binding [GO:0005525]	intracellular [GO:0005622]	GO:0005525; GO:0005622; GO:0007264		Complete proteome; GTP-binding; Nucleotide-binding; Reference proteome	
H3BRA5_HUMAN	H3BRA5	H3BRA5_HUMAN	unreviewed	UPF0183 protein C16orf70 (Fragment)	C16orf70	Homo sapiens (Human)	165							Complete proteome; Proteomics identification; Reference proteome	Non-terminal residue (1)
C9JCG1_HUMAN	C9JCG1	C9JCG1_HUMAN	unreviewed	Zinc finger protein 143 (Fragment)	ZNF143	Homo sapiens (Human)	84							Complete proteome; Proteomics identification; Reference proteome	Non-terminal residue (1)
CYTB_HUMAN	P04080	CYTB_HUMAN	reviewed	Cystatin-B (CPI-B) (Liver thiol proteinase inhibitor) (Stefin-B)	CSTB CST6 STFB	Homo sapiens (Human)	98	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleolus [GO:0005730]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; endopeptidase inhibitor activity [GO:0004866]; poly(A) RNA binding [GO:0044822]; protease binding [GO:0002020]; adult locomotory behavior [GO:0008344]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of peptidase activity [GO:0010466]; negative regulation of proteolysis [GO:0045861]; regulation of apoptotic process [GO:0042981]	adult locomotory behavior [GO:0008344]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of peptidase activity [GO:0010466]; negative regulation of proteolysis [GO:0045861]; regulation of apoptotic process [GO:0042981]	cysteine-type endopeptidase inhibitor activity [GO:0004869]; endopeptidase inhibitor activity [GO:0004866]; poly(A) RNA binding [GO:0044822]; protease binding [GO:0002020]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleolus [GO:0005730]	GO:0008344; GO:0004869; GO:0005737; GO:0004866; GO:0070062; GO:0005615; GO:0010951; GO:0010466; GO:0045861; GO:0005730; GO:0044822; GO:0002020; GO:0042981	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11139332}. Nucleus {ECO:0000269|PubMed:11139332}.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Epilepsy; Nucleus; Protease inhibitor; Reference proteome; Thiol protease inhibitor	Beta strand (4); Chain (1); Helix (1); Modified residue (1); Motif (1); Natural variant (1); Sequence conflict (1); Site (1)
RS24_HUMAN	P62847	RS24_HUMAN	reviewed	40S ribosomal protein S24	RPS24	Homo sapiens (Human)	133	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; membrane [GO:0016020]; nucleus [GO:0005634]; small ribosomal subunit [GO:0015935]; nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; structural constituent of ribosome [GO:0003735]; translation initiation factor binding [GO:0031369]; cellular protein metabolic process [GO:0044267]; erythrocyte homeostasis [GO:0034101]; gene expression [GO:0010467]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	cellular protein metabolic process [GO:0044267]; erythrocyte homeostasis [GO:0034101]; gene expression [GO:0010467]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; structural constituent of ribosome [GO:0003735]; translation initiation factor binding [GO:0031369]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; membrane [GO:0016020]; nucleus [GO:0005634]; small ribosomal subunit [GO:0015935]	GO:0006614; GO:0044267; GO:0005737; GO:0005829; GO:0022627; GO:0034101; GO:0010467; GO:0000462; GO:0016020; GO:0000184; GO:0000166; GO:0005634; GO:0044822; GO:0006364; GO:0042274; GO:0015935; GO:0003735; GO:0006412; GO:0031369; GO:0006414; GO:0006413; GO:0006415; GO:0019058; GO:0016032; GO:0019083		3D-structure; Acetylation; Alternative splicing; Complete proteome; Diamond-Blackfan anemia; Direct protein sequencing; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein	Alternative sequence (3); Chain (1); Modified residue (2)
FPPS_HUMAN	P14324	FPPS_HUMAN	reviewed	Farnesyl pyrophosphate synthase (FPP synthase) (FPS) (EC 2.5.1.10) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Geranyltranstransferase)	FDPS FPS KIAA1293	Homo sapiens (Human)	419	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; dimethylallyltranstransferase activity [GO:0004161]; geranyltranstransferase activity [GO:0004337]; metal ion binding [GO:0046872]; poly(A) RNA binding [GO:0044822]; cholesterol biosynthetic process [GO:0006695]; farnesyl diphosphate biosynthetic process [GO:0045337]; geranyl diphosphate biosynthetic process [GO:0033384]; small molecule metabolic process [GO:0044281]; viral process [GO:0016032]	cholesterol biosynthetic process [GO:0006695]; farnesyl diphosphate biosynthetic process [GO:0045337]; geranyl diphosphate biosynthetic process [GO:0033384]; small molecule metabolic process [GO:0044281]; viral process [GO:0016032]	dimethylallyltranstransferase activity [GO:0004161]; geranyltranstransferase activity [GO:0004337]; metal ion binding [GO:0046872]; poly(A) RNA binding [GO:0044822]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	GO:0006695; GO:0005737; GO:0005829; GO:0004161; GO:0045337; GO:0033384; GO:0004337; GO:0046872; GO:0005739; GO:0005654; GO:0044822; GO:0044281; GO:0016032	SUBCELLULAR LOCATION: Cytoplasm.	3D-structure; Acetylation; Alternative splicing; Cholesterol biosynthesis; Cholesterol metabolism; Complete proteome; Cytoplasm; Host-virus interaction; Isoprene biosynthesis; Lipid biosynthesis; Lipid metabolism; Magnesium; Metal-binding; Polymorphism; Reference proteome; Steroid biosynthesis; Steroid metabolism; Sterol biosynthesis; Sterol metabolism; Transferase	Alternative sequence (1); Beta strand (3); Binding site (10); Chain (1); Erroneous initiation (1); Helix (23); Metal binding (5); Modified residue (3); Natural variant (2); Sequence conflict (3); Site (2); Turn (2)
SMRCD_HUMAN	Q9H4L7	SMRCD_HUMAN	reviewed	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1)	SMARCAD1 KIAA1122	Homo sapiens (Human)	1026	heterochromatin [GO:0000792]; nuclear matrix [GO:0016363]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; nucleic acid binding [GO:0003676]; ATP-dependent chromatin remodeling [GO:0043044]; chromatin modification [GO:0016568]; chromatin remodeling [GO:0006338]; chromosome separation [GO:0051304]; DNA double-strand break processing [GO:0000729]; histone H3 deacetylation [GO:0070932]; histone H4 deacetylation [GO:0070933]; nucleotide metabolic process [GO:0009117]; positive regulation of transcription, DNA-templated [GO:0045893]; protein homooligomerization [GO:0051260]; regulation of DNA recombination [GO:0000018]	ATP-dependent chromatin remodeling [GO:0043044]; chromatin modification [GO:0016568]; chromatin remodeling [GO:0006338]; chromosome separation [GO:0051304]; DNA double-strand break processing [GO:0000729]; histone H3 deacetylation [GO:0070932]; histone H4 deacetylation [GO:0070933]; nucleotide metabolic process [GO:0009117]; positive regulation of transcription, DNA-templated [GO:0045893]; protein homooligomerization [GO:0051260]; regulation of DNA recombination [GO:0000018]	ATP binding [GO:0005524]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; nucleic acid binding [GO:0003676]	heterochromatin [GO:0000792]; nuclear matrix [GO:0016363]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861]	GO:0005524; GO:0043044; GO:0003677; GO:0000729; GO:0016568; GO:0006338; GO:0051304; GO:0004386; GO:0000792; GO:0070932; GO:0070933; GO:0016363; GO:0043596; GO:0003676; GO:0005654; GO:0009117; GO:0045893; GO:0051260; GO:0000018; GO:0035861	SUBCELLULAR LOCATION: Nucleus. Chromosome. Note=Colocalizes with PCNA at replication forks during S phase. Recruited to double-strand breaks (DSBs) sites of DNA damage.	ATP-binding; Acetylation; Alternative splicing; Chromatin regulator; Chromosome; Complete proteome; DNA damage; DNA repair; DNA-binding; Helicase; Hydrolase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat	Alternative sequence (2); Chain (1); Domain (4); Erroneous initiation (2); Modified residue (15); Motif (3); Mutagenesis (1); Natural variant (8); Nucleotide binding (2); Sequence caution (1); Sequence conflict (2)
K7EQ02_HUMAN	K7EQ02	K7EQ02_HUMAN	unreviewed	DAZ-associated protein 1 (Fragment)	DAZAP1	Homo sapiens (Human)	327	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleic acid binding [GO:0003676]; nucleotide binding [GO:0000166]		nucleic acid binding [GO:0003676]; nucleotide binding [GO:0000166]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]	GO:0005737; GO:0003676; GO:0005654; GO:0000166		Complete proteome; Proteomics identification; Reference proteome	Non-terminal residue (1)
DAZP1_HUMAN	Q96EP5	DAZP1_HUMAN	reviewed	DAZ-associated protein 1 (Deleted in azoospermia-associated protein 1)	DAZAP1	Homo sapiens (Human)	407	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; RNA stem-loop binding [GO:0035613]; cell differentiation [GO:0030154]; cell proliferation [GO:0008283]; maternal placenta development [GO:0001893]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; spermatogenesis [GO:0007283]	cell differentiation [GO:0030154]; cell proliferation [GO:0008283]; maternal placenta development [GO:0001893]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; spermatogenesis [GO:0007283]	nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; RNA stem-loop binding [GO:0035613]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]	GO:0003723; GO:0035613; GO:0030154; GO:0008283; GO:0005737; GO:0001893; GO:0005654; GO:0000166; GO:0044822; GO:0048026; GO:0007283	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22001406}. Nucleus {ECO:0000269|PubMed:22001406}. Note=Predominantly cytoplasmic (By similarity). Nuclear at some stages of spermatozoides development. In midpachytene spermatocytes, it is localized in both the cytoplasm and the nuclei and is clearly excluded from the sex vesicles. In round spermatids, it localizes mainly in the nuclei, whereas in elongated spermatids, it localizes to the cytoplasm (By similarity). {ECO:0000250}.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Direct protein sequencing; Nucleus; Polymorphism; RNA-binding; Reference proteome; Repeat; Spermatogenesis	Alternative sequence (1); Beta strand (12); Chain (1); Compositional bias (1); Domain (2); Erroneous initiation (1); Helix (4); Modified residue (2); Natural variant (1); Sequence conflict (1); Turn (1)
TF3C4_HUMAN	Q9UKN8	TF3C4_HUMAN	reviewed	General transcription factor 3C polypeptide 4 (EC 2.3.1.48) (TF3C-delta) (Transcription factor IIIC 90 kDa subunit) (TFIIIC 90 kDa subunit) (TFIIIC90) (Transcription factor IIIC subunit delta)	GTF3C4	Homo sapiens (Human)	822	nucleoplasm [GO:0005654]; transcription factor TFIIIC complex [GO:0000127]; DNA binding [GO:0003677]; enzyme activator activity [GO:0008047]; histone acetyltransferase activity [GO:0004402]; 5S class rRNA transcription from RNA polymerase III type 1 promoter [GO:0042791]; gene expression [GO:0010467]; histone acetylation [GO:0016573]; positive regulation of catalytic activity [GO:0043085]; transcription from RNA polymerase III promoter [GO:0006383]; transcription initiation from RNA polymerase III promoter [GO:0006384]; transcription, DNA-templated [GO:0006351]; tRNA transcription from RNA polymerase III promoter [GO:0042797]	5S class rRNA transcription from RNA polymerase III type 1 promoter [GO:0042791]; gene expression [GO:0010467]; histone acetylation [GO:0016573]; positive regulation of catalytic activity [GO:0043085]; transcription, DNA-templated [GO:0006351]; transcription from RNA polymerase III promoter [GO:0006383]; transcription initiation from RNA polymerase III promoter [GO:0006384]; tRNA transcription from RNA polymerase III promoter [GO:0042797]	DNA binding [GO:0003677]; enzyme activator activity [GO:0008047]; histone acetyltransferase activity [GO:0004402]	nucleoplasm [GO:0005654]; transcription factor TFIIIC complex [GO:0000127]	GO:0042791; GO:0003677; GO:0008047; GO:0010467; GO:0016573; GO:0004402; GO:0005654; GO:0043085; GO:0042797; GO:0000127; GO:0006383; GO:0006384; GO:0006351	SUBCELLULAR LOCATION: Nucleus.	Acetylation; Acyltransferase; Complete proteome; DNA-binding; Direct protein sequencing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transferase	Chain (1); Modified residue (2); Natural variant (1); Sequence caution (1); Sequence conflict (6)
Q5SZC9_HUMAN	Q5SZC9	Q5SZC9_HUMAN	unreviewed	Costars family protein ABRACL	ABRACL	Homo sapiens (Human)	67							Complete proteome; Proteomics identification; Reference proteome	
PDCL3_HUMAN	Q9H2J4	PDCL3_HUMAN	reviewed	Phosducin-like protein 3 (HTPHLP) (PhPL3) (Viral IAP-associated factor 1) (VIAF-1)	PDCL3 PhLP2A VIAF1	Homo sapiens (Human)	239	cytoplasm [GO:0005737]; protein binding involved in protein folding [GO:0044183]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell proliferation [GO:0001938]; protein folding [GO:0006457]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; viral process [GO:0016032]	angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell proliferation [GO:0001938]; protein folding [GO:0006457]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; viral process [GO:0016032]	protein binding involved in protein folding [GO:0044183]	cytoplasm [GO:0005737]	GO:0001525; GO:0006915; GO:0005737; GO:2000059; GO:0045766; GO:0001938; GO:0044183; GO:0006457; GO:0050730; GO:0016032	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15371430}.	Angiogenesis; Apoptosis; Complete proteome; Cytoplasm; Host-virus interaction; Phosphoprotein; Reference proteome	Chain (1); Modified residue (2); Region (1)
ATG3_HUMAN	Q9NT62	ATG3_HUMAN	reviewed	Ubiquitin-like-conjugating enzyme ATG3 (EC 6.3.2.-) (Autophagy-related protein 3) (APG3-like) (hApg3) (Protein PC3-96)	ATG3 APG3 APG3L	Homo sapiens (Human)	314	cytoplasmic ubiquitin ligase complex [GO:0000153]; cytosol [GO:0005829]; Atg12 transferase activity [GO:0019777]; Atg8 ligase activity [GO:0019776]; enzyme binding [GO:0019899]; ligase activity [GO:0016874]; ubiquitin-like protein transferase activity [GO:0019787]; autophagic vacuole assembly [GO:0000045]; cellular protein modification process [GO:0006464]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrion degradation [GO:0000422]; nucleophagy [GO:0044804]; protein targeting to membrane [GO:0006612]; protein ubiquitination [GO:0016567]; regulation of cilium assembly [GO:1902017]	autophagic vacuole assembly [GO:0000045]; cellular protein modification process [GO:0006464]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrion degradation [GO:0000422]; nucleophagy [GO:0044804]; protein targeting to membrane [GO:0006612]; protein ubiquitination [GO:0016567]; regulation of cilium assembly [GO:1902017]	Atg12 transferase activity [GO:0019777]; Atg8 ligase activity [GO:0019776]; enzyme binding [GO:0019899]; ligase activity [GO:0016874]; ubiquitin-like protein transferase activity [GO:0019787]	cytoplasmic ubiquitin ligase complex [GO:0000153]; cytosol [GO:0005829]	GO:0019777; GO:0019776; GO:0000045; GO:0006464; GO:0000153; GO:0005829; GO:0019899; GO:0016874; GO:0043653; GO:0000422; GO:0044804; GO:0006612; GO:0016567; GO:1902017; GO:0019787	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11825910}.	3D-structure; Acetylation; Alternative splicing; Autophagy; Complete proteome; Cytoplasm; Isopeptide bond; Ligase; Protein transport; Reference proteome; Transport; Ubl conjugation; Ubl conjugation pathway	Active site (1); Alternative sequence (1); Chain (1); Cross-link (1); Erroneous initiation (1); Frameshift (2); Helix (1); Modified residue (1); Motif (1); Mutagenesis (1); Site (1)
TEBP_HUMAN	Q15185	TEBP_HUMAN	reviewed	Prostaglandin E synthase 3 (EC 5.3.99.3) (Cytosolic prostaglandin E2 synthase) (cPGES) (Hsp90 co-chaperone) (Progesterone receptor complex p23) (Telomerase-binding protein p23)	PTGES3 P23 TEBP	Homo sapiens (Human)	160	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; telomerase holoenzyme complex [GO:0005697]; prostaglandin-E synthase activity [GO:0050220]; telomerase activity [GO:0003720]; unfolded protein binding [GO:0051082]; arachidonic acid metabolic process [GO:0019369]; cellular response to heat [GO:0034605]; chaperone cofactor-dependent protein refolding [GO:0070389]; cyclooxygenase pathway [GO:0019371]; prostaglandin biosynthetic process [GO:0001516]; regulation of cellular response to heat [GO:1900034]; RNA-dependent DNA replication [GO:0006278]; signal transduction [GO:0007165]; small molecule metabolic process [GO:0044281]; telomere maintenance [GO:0000723]	arachidonic acid metabolic process [GO:0019369]; cellular response to heat [GO:0034605]; chaperone cofactor-dependent protein refolding [GO:0070389]; cyclooxygenase pathway [GO:0019371]; prostaglandin biosynthetic process [GO:0001516]; regulation of cellular response to heat [GO:1900034]; RNA-dependent DNA replication [GO:0006278]; signal transduction [GO:0007165]; small molecule metabolic process [GO:0044281]; telomere maintenance [GO:0000723]	prostaglandin-E synthase activity [GO:0050220]; telomerase activity [GO:0003720]; unfolded protein binding [GO:0051082]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; telomerase holoenzyme complex [GO:0005697]	GO:0006278; GO:0019369; GO:0034605; GO:0070389; GO:0000781; GO:0019371; GO:0005737; GO:0005829; GO:0070062; GO:0005654; GO:0005634; GO:0001516; GO:0050220; GO:1900034; GO:0007165; GO:0044281; GO:0003720; GO:0005697; GO:0000723; GO:0051082	SUBCELLULAR LOCATION: Cytoplasm.	3D-structure; Acetylation; Alternative splicing; Chaperone; Complete proteome; Cytoplasm; Direct protein sequencing; Fatty acid biosynthesis; Fatty acid metabolism; Isomerase; Lipid biosynthesis; Lipid metabolism; Phosphoprotein; Prostaglandin biosynthesis; Prostaglandin metabolism; Reference proteome	Alternative sequence (3); Beta strand (9); Chain (1); Compositional bias (1); Domain (1); Modified residue (6); Motif (1); Turn (2)
C2AIL_HUMAN	Q96HQ2	C2AIL_HUMAN	reviewed	CDKN2AIP N-terminal-like protein (CDKN2A-interacting protein N-terminal-like protein)	CDKN2AIPNL	Homo sapiens (Human)	116							Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Reference proteome	Alternative sequence (1); Chain (1); Modified residue (1)
PRPS1_HUMAN	P60891	PRPS1_HUMAN	reviewed	Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase I) (PRS-I)	PRPS1	Homo sapiens (Human)	318	cytosol [GO:0005829]; ribose phosphate diphosphokinase complex [GO:0002189]; ADP binding [GO:0043531]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; carbohydrate binding [GO:0030246]; GDP binding [GO:0019003]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; ribose phosphate diphosphokinase activity [GO:0004749]; 5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; AMP biosynthetic process [GO:0006167]; carbohydrate metabolic process [GO:0005975]; hypoxanthine biosynthetic process [GO:0046101]; nervous system development [GO:0007399]; organ regeneration [GO:0031100]; purine nucleobase metabolic process [GO:0006144]; purine nucleotide biosynthetic process [GO:0006164]; pyrimidine nucleotide biosynthetic process [GO:0006221]; small molecule metabolic process [GO:0044281]; urate biosynthetic process [GO:0034418]	5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; AMP biosynthetic process [GO:0006167]; carbohydrate metabolic process [GO:0005975]; hypoxanthine biosynthetic process [GO:0046101]; nervous system development [GO:0007399]; organ regeneration [GO:0031100]; purine nucleobase metabolic process [GO:0006144]; purine nucleotide biosynthetic process [GO:0006164]; pyrimidine nucleotide biosynthetic process [GO:0006221]; small molecule metabolic process [GO:0044281]; urate biosynthetic process [GO:0034418]	ADP binding [GO:0043531]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; carbohydrate binding [GO:0030246]; GDP binding [GO:0019003]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; ribose phosphate diphosphokinase activity [GO:0004749]	cytosol [GO:0005829]; ribose phosphate diphosphokinase complex [GO:0002189]	GO:0006015; GO:0043531; GO:0016208; GO:0006167; GO:0005524; GO:0019003; GO:0030246; GO:0005975; GO:0005829; GO:0046101; GO:0016301; GO:0000287; GO:0007399; GO:0031100; GO:0042803; GO:0006144; GO:0006164; GO:0006221; GO:0004749; GO:0002189; GO:0044281; GO:0034418		3D-structure; ATP-binding; Alternative splicing; Charcot-Marie-Tooth disease; Complete proteome; Deafness; Direct protein sequencing; Disease mutation; Gout; Kinase; Magnesium; Mental retardation; Metal-binding; Neurodegeneration; Neuropathy; Non-syndromic deafness; Nucleotide biosynthesis; Nucleotide-binding; Polymorphism; Reference proteome; Retinitis pigmentosa; Transferase	Alternative sequence (1); Beta strand (16); Binding site (1); Chain (1); Helix (13); Initiator methionine (1); Metal binding (4); Mutagenesis (5); Natural variant (18); Nucleotide binding (1); Region (1); Sequence conflict (3); Turn (2)
KCAB2_HUMAN	Q13303	KCAB2_HUMAN	reviewed	Voltage-gated potassium channel subunit beta-2 (EC 1.1.1.-) (K(+) channel subunit beta-2) (Kv-beta-2) (hKvbeta2)	KCNAB2 KCNA2B KCNK2	Homo sapiens (Human)	367	cell junction [GO:0030054]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; juxtaparanode region of axon [GO:0044224]; membrane [GO:0016020]; pinceau fiber [GO:1990031]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated potassium channel complex [GO:0008076]; aldo-keto reductase (NADP) activity [GO:0004033]; potassium channel regulator activity [GO:0015459]; voltage-gated potassium channel activity [GO:0005249]; hematopoietic progenitor cell differentiation [GO:0002244]; NADPH oxidation [GO:0070995]; oxidation-reduction process [GO:0055114]; protein heterooligomerization [GO:0051291]; regulation of potassium ion transmembrane transport [GO:1901379]; regulation of protein localization to cell surface [GO:2000008]; synaptic transmission [GO:0007268]	hematopoietic progenitor cell differentiation [GO:0002244]; NADPH oxidation [GO:0070995]; oxidation-reduction process [GO:0055114]; protein heterooligomerization [GO:0051291]; regulation of potassium ion transmembrane transport [GO:1901379]; regulation of protein localization to cell surface [GO:2000008]; synaptic transmission [GO:0007268]	aldo-keto reductase (NADP) activity [GO:0004033]; potassium channel regulator activity [GO:0015459]; voltage-gated potassium channel activity [GO:0005249]	cell junction [GO:0030054]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; juxtaparanode region of axon [GO:0044224]; membrane [GO:0016020]; pinceau fiber [GO:1990031]; plasma membrane [GO:0005886]; synapse [GO:0045202]; voltage-gated potassium channel complex [GO:0008076]	GO:0070995; GO:0004033; GO:0030054; GO:0005856; GO:0005829; GO:0031234; GO:0002244; GO:0044224; GO:0016020; GO:0055114; GO:1990031; GO:0005886; GO:0015459; GO:0051291; GO:1901379; GO:2000008; GO:0045202; GO:0007268; GO:0005249; GO:0008076	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P62483}. Membrane {ECO:0000269|PubMed:11086297, ECO:0000269|PubMed:21357749}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:P62483}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell projection, axon {ECO:0000269|PubMed:11086297}. Cell junction, synapse, synaptosome {ECO:0000269|PubMed:21357749}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P62483}. Note=Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits. Associates with microtubules when unphosphorylated. {ECO:0000250|UniProtKB:P62483}.	3D-structure; Acetylation; Alternative splicing; Cell junction; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Ion channel; Ion transport; Membrane; NADP; Oxidoreductase; Phosphoprotein; Polymorphism; Potassium; Potassium transport; Reference proteome; Synapse; Synaptosome; Transport; Voltage-gated channel	Active site (1); Alternative sequence (5); Beta strand (10); Binding site (5); Chain (1); Helix (20); Modified residue (5); Mutagenesis (1); Natural variant (1); Nucleotide binding (4); Turn (1)
AP2A1_HUMAN	O95782	AP2A1_HUMAN	reviewed	AP-2 complex subunit alpha-1 (100 kDa coated vesicle protein A) (Adaptor protein complex AP-2 subunit alpha-1) (Adaptor-related protein complex 2 subunit alpha-1) (Alpha-adaptin A) (Alpha1-adaptin) (Clathrin assembly protein complex 2 alpha-A large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit)	AP2A1 ADTAA CLAPA1	Homo sapiens (Human)	977	AP-2 adaptor complex [GO:0030122]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; clathrin coat of trans-Golgi network vesicle [GO:0030130]; clathrin-coated endocytic vesicle membrane [GO:0030669]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; membrane [GO:0016020]; plasma membrane [GO:0005886]; protein kinase binding [GO:0019901]; protein transporter activity [GO:0008565]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; axon guidance [GO:0007411]; clathrin-mediated endocytosis [GO:0072583]; endocytosis [GO:0006897]; ephrin receptor signaling pathway [GO:0048013]; epidermal growth factor receptor signaling pathway [GO:0007173]; Golgi to endosome transport [GO:0006895]; intracellular protein transport [GO:0006886]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of hyaluronan biosynthetic process [GO:1900126]; neurotrophin TRK receptor signaling pathway [GO:0048011]; regulation of defense response to virus by virus [GO:0050690]; synaptic transmission [GO:0007268]; viral process [GO:0016032]	antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; axon guidance [GO:0007411]; clathrin-mediated endocytosis [GO:0072583]; endocytosis [GO:0006897]; ephrin receptor signaling pathway [GO:0048013]; epidermal growth factor receptor signaling pathway [GO:0007173]; Golgi to endosome transport [GO:0006895]; intracellular protein transport [GO:0006886]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of hyaluronan biosynthetic process [GO:1900126]; neurotrophin TRK receptor signaling pathway [GO:0048011]; regulation of defense response to virus by virus [GO:0050690]; synaptic transmission [GO:0007268]; viral process [GO:0016032]	protein kinase binding [GO:0019901]; protein transporter activity [GO:0008565]	AP-2 adaptor complex [GO:0030122]; apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin coat of trans-Golgi network vesicle [GO:0030130]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; membrane [GO:0016020]; plasma membrane [GO:0005886]	GO:0030122; GO:0006895; GO:0019886; GO:0016324; GO:0007411; GO:0016323; GO:0030130; GO:0030669; GO:0072583; GO:0005829; GO:0030666; GO:0006897; GO:0048013; GO:0007173; GO:0006886; GO:0016020; GO:0042059; GO:1900126; GO:0048011; GO:0005886; GO:0019901; GO:0008565; GO:0050690; GO:0007268; GO:0016032	SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}. Membrane, coated pit {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV. {ECO:0000250}.	Alternative splicing; Cell membrane; Coated pit; Complete proteome; Endocytosis; Membrane; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport	Alternative sequence (1); Chain (1); Erroneous gene model prediction (1); Initiator methionine (1); Modified residue (4); Natural variant (1); Sequence conflict (3)
BLVRB_HUMAN	P30043	BLVRB_HUMAN	reviewed	Flavin reductase (NADPH) (FR) (EC 1.5.1.30) (Biliverdin reductase B) (BVR-B) (EC 1.3.1.24) (Biliverdin-IX beta-reductase) (Green heme-binding protein) (GHBP) (NADPH-dependent diaphorase) (NADPH-flavin reductase) (FLR)	BLVRB FLR	Homo sapiens (Human)	206	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; biliverdin reductase activity [GO:0004074]; riboflavin reductase (NADPH) activity [GO:0042602]; heme catabolic process [GO:0042167]; porphyrin-containing compound metabolic process [GO:0006778]; small molecule metabolic process [GO:0044281]	heme catabolic process [GO:0042167]; porphyrin-containing compound metabolic process [GO:0006778]; small molecule metabolic process [GO:0044281]	biliverdin reductase activity [GO:0004074]; riboflavin reductase (NADPH) activity [GO:0042602]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	GO:0004074; GO:0005737; GO:0005829; GO:0070062; GO:0042167; GO:0005654; GO:0005886; GO:0006778; GO:0042602; GO:0044281	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:7929092}.	3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; NADP; Oxidoreductase; Phosphoprotein; Polymorphism; Reference proteome	Beta strand (11); Binding site (4); Chain (1); Helix (10); Initiator methionine (1); Modified residue (1); Mutagenesis (1); Natural variant (1); Nucleotide binding (3); Sequence conflict (1); Turn (1)
RL31_HUMAN	P62899	RL31_HUMAN	reviewed	60S ribosomal protein L31	RPL31	Homo sapiens (Human)	125	cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]	GO:0003723; GO:0006614; GO:0044267; GO:0005829; GO:0022625; GO:0070062; GO:0005925; GO:0010467; GO:0016020; GO:0000184; GO:0044822; GO:0003735; GO:0006412; GO:0006414; GO:0006413; GO:0006415; GO:0019058; GO:0016032; GO:0019083		3D-structure; Acetylation; Alternative splicing; Complete proteome; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein	Alternative sequence (2); Chain (1); Modified residue (6)
PRUN2_HUMAN	Q8WUY3	PRUN2_HUMAN	reviewed	Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1)	PRUNE2 BMCC1 BNIPXL C9orf65 KIAA0367	Homo sapiens (Human)	3088	cytoplasm [GO:0005737]; metal ion binding [GO:0046872]; pyrophosphatase activity [GO:0016462]; apoptotic process [GO:0006915]	apoptotic process [GO:0006915]	metal ion binding [GO:0046872]; pyrophosphatase activity [GO:0016462]	cytoplasm [GO:0005737]	GO:0006915; GO:0005737; GO:0046872; GO:0016462	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16288218}.	Acetylation; Alternative splicing; Apoptosis; Complete proteome; Cytoplasm; Manganese; Metal-binding; Polymorphism; Reference proteome	Alternative sequence (5); Chain (1); Compositional bias (1); Domain (1); Erroneous gene model prediction (3); Erroneous initiation (4); Modified residue (1); Motif (1); Natural variant (1); Sequence caution (1); Sequence conflict (19)
RS26_HUMAN	P62854	RS26_HUMAN	reviewed	40S ribosomal protein S26	RPS26	Homo sapiens (Human)	115	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730]; small ribosomal subunit [GO:0015935]; mRNA binding [GO:0003729]; poly(A) RNA binding [GO:0044822]; structural constituent of ribosome [GO:0003735]; cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; negative regulation of RNA splicing [GO:0033119]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; negative regulation of RNA splicing [GO:0033119]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	mRNA binding [GO:0003729]; poly(A) RNA binding [GO:0044822]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730]; small ribosomal subunit [GO:0015935]	GO:0006614; GO:0044267; GO:0005737; GO:0005829; GO:0022627; GO:0070062; GO:0010467; GO:0003729; GO:0016020; GO:0033119; GO:0000184; GO:0005730; GO:0044822; GO:0015935; GO:0003735; GO:0006412; GO:0006414; GO:0006413; GO:0006415; GO:0019058; GO:0016032; GO:0019083		3D-structure; Complete proteome; Diamond-Blackfan anemia; Direct protein sequencing; Disease mutation; Reference proteome; Ribonucleoprotein; Ribosomal protein	Chain (1); Initiator methionine (1); Natural variant (2); Sequence conflict (2)
KAPCA_HUMAN	P17612	KAPCA_HUMAN	reviewed	cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11)	PRKACA PKACA	Homo sapiens (Human)	351	AMP-activated protein kinase complex [GO:0031588]; calcium channel complex [GO:0034704]; cAMP-dependent protein kinase complex [GO:0005952]; centrosome [GO:0005813]; ciliary base [GO:0097546]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; motile cilium [GO:0031514]; neuromuscular junction [GO:0031594]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; sperm midpiece [GO:0097225]; ATP binding [GO:0005524]; cAMP-dependent protein kinase activity [GO:0004691]; protein kinase A regulatory subunit binding [GO:0034237]; protein kinase binding [GO:0019901]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; ubiquitin protein ligase binding [GO:0031625]; activation of phospholipase C activity [GO:0007202]; activation of protein kinase A activity [GO:0034199]; blood coagulation [GO:0007596]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; carbohydrate metabolic process [GO:0005975]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cellular response to epinephrine stimulus [GO:0071872]; cellular response to glucagon stimulus [GO:0071377]; cellular response to glucose stimulus [GO:0071333]; cellular response to parathyroid hormone stimulus [GO:0071374]; cytosolic calcium ion homeostasis [GO:0051480]; energy reserve metabolic process [GO:0006112]; epidermal growth factor receptor signaling pathway [GO:0007173]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G2/M transition of mitotic cell cycle [GO:0000086]; gluconeogenesis [GO:0006094]; glucose metabolic process [GO:0006006]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; mesoderm formation [GO:0001707]; mitotic cell cycle [GO:0000278]; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901621]; neural tube closure [GO:0001843]; neurotrophin TRK receptor signaling pathway [GO:0048011]; organelle organization [GO:0006996]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of cell cycle arrest [GO:0071158]; positive regulation of protein export from nucleus [GO:0046827]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of bicellular tight junction assembly [GO:2000810]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of insulin secretion [GO:0050796]; regulation of osteoblast differentiation [GO:0045667]; regulation of proteasomal protein catabolic process [GO:0061136]; regulation of protein binding [GO:0043393]; regulation of protein processing [GO:0070613]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; regulation of synaptic transmission [GO:0050804]; renal water homeostasis [GO:0003091]; signal transduction [GO:0007165]; small molecule metabolic process [GO:0044281]; sperm capacitation [GO:0048240]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; transmembrane transport [GO:0055085]; triglyceride catabolic process [GO:0019433]; water transport [GO:0006833]	activation of phospholipase C activity [GO:0007202]; activation of protein kinase A activity [GO:0034199]; blood coagulation [GO:0007596]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; carbohydrate metabolic process [GO:0005975]; cell communication by electrical coupling involved in cardiac conduction [GO:0086064]; cellular response to epinephrine stimulus [GO:0071872]; cellular response to glucagon stimulus [GO:0071377]; cellular response to glucose stimulus [GO:0071333]; cellular response to parathyroid hormone stimulus [GO:0071374]; cytosolic calcium ion homeostasis [GO:0051480]; energy reserve metabolic process [GO:0006112]; epidermal growth factor receptor signaling pathway [GO:0007173]; fibroblast growth factor receptor signaling pathway [GO:0008543]; G2/M transition of mitotic cell cycle [GO:0000086]; gluconeogenesis [GO:0006094]; glucose metabolic process [GO:0006006]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; mesoderm formation [GO:0001707]; mitotic cell cycle [GO:0000278]; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901621]; neural tube closure [GO:0001843]; neurotrophin TRK receptor signaling pathway [GO:0048011]; organelle organization [GO:0006996]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of cell cycle arrest [GO:0071158]; positive regulation of protein export from nucleus [GO:0046827]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of bicellular tight junction assembly [GO:2000810]; regulation of cardiac muscle contraction [GO:0055117]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of heart rate [GO:0002027]; regulation of insulin secretion [GO:0050796]; regulation of osteoblast differentiation [GO:0045667]; regulation of proteasomal protein catabolic process [GO:0061136]; regulation of protein binding [GO:0043393]; regulation of protein processing [GO:0070613]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]; regulation of synaptic transmission [GO:0050804]; renal water homeostasis [GO:0003091]; signal transduction [GO:0007165]; small molecule metabolic process [GO:0044281]; sperm capacitation [GO:0048240]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; transmembrane transport [GO:0055085]; triglyceride catabolic process [GO:0019433]; water transport [GO:0006833]	ATP binding [GO:0005524]; cAMP-dependent protein kinase activity [GO:0004691]; protein kinase A regulatory subunit binding [GO:0034237]; protein kinase binding [GO:0019901]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; ubiquitin protein ligase binding [GO:0031625]	AMP-activated protein kinase complex [GO:0031588]; calcium channel complex [GO:0034704]; cAMP-dependent protein kinase complex [GO:0005952]; centrosome [GO:0005813]; ciliary base [GO:0097546]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; motile cilium [GO:0031514]; neuromuscular junction [GO:0031594]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; sperm midpiece [GO:0097225]	GO:0031588; GO:0005524; GO:0000086; GO:0007202; GO:0034199; GO:0007596; GO:0004691; GO:0005952; GO:0034704; GO:0035584; GO:0005975; GO:0086064; GO:0071872; GO:0071377; GO:0071333; GO:0071374; GO:0005813; GO:0097546; GO:0005829; GO:0051480; GO:0006112; GO:0007173; GO:0070062; GO:0008543; GO:0006094; GO:0006006; GO:0045087; GO:0035556; GO:0001707; GO:0005739; GO:0000278; GO:0031514; GO:1901621; GO:0001843; GO:0031594; GO:0048011; GO:0005654; GO:0005634; GO:0006996; GO:0018105; GO:0018107; GO:0005886; GO:0071158; GO:0046827; GO:0046777; GO:0034237; GO:0019901; GO:0006468; GO:0004712; GO:2000810; GO:0055117; GO:0010881; GO:0002027; GO:0050796; GO:0045667; GO:0061136; GO:0043393; GO:0070613; GO:0060314; GO:0050804; GO:0003091; GO:0007165; GO:0044281; GO:0048240; GO:0097225; GO:0002223; GO:0055085; GO:0019433; GO:0031625; GO:0006833	SUBCELLULAR LOCATION: Cytoplasm. Cell membrane. Nucleus {ECO:0000250}. Mitochondrion {ECO:0000250}. Note=Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm. Distributed throughout the cytoplasm in meiotically incompetent oocytes. Associated to mitochondrion as meiotic competence is acquired. Aggregates around the germinal vesicles (GV) at the immature GV stage oocytes (By similarity). {ECO:0000250}.; SUBCELLULAR LOCATION: Isoform 2: Cell projection, cilium, flagellum. Note=Expressed in the midpiece region of the sperm flagellum.	3D-structure; ATP-binding; Alternative splicing; Cell membrane; Cell projection; Cilium; Complete proteome; Cushing syndrome; Cytoplasm; Disease mutation; Flagellum; Kinase; Lipoprotein; Membrane; Mitochondrion; Myristate; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase; cAMP	Active site (1); Alternative sequence (1); Beta strand (8); Binding site (1); Chain (1); Domain (2); Helix (16); Initiator methionine (1); Lipidation (1); Modified residue (9); Mutagenesis (10); Natural variant (4); Nucleotide binding (3); Turn (5)
IF6_HUMAN	P56537	IF6_HUMAN	reviewed	Eukaryotic translation initiation factor 6 (eIF-6) (B(2)GCN homolog) (B4 integrin interactor) (CAB) (p27(BBP))	EIF6 EIF3A ITGB4BP OK/SW-cl.27	Homo sapiens (Human)	245	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; lamin filament [GO:0005638]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribosomal large subunit binding [GO:0043023]; ribosome binding [GO:0043022]; translation initiation factor activity [GO:0003743]; mature ribosome assembly [GO:0042256]; ribosomal large subunit biogenesis [GO:0042273]; ribosomal subunit export from nucleus [GO:0000054]	mature ribosome assembly [GO:0042256]; ribosomal large subunit biogenesis [GO:0042273]; ribosomal subunit export from nucleus [GO:0000054]	ribosomal large subunit binding [GO:0043023]; ribosome binding [GO:0043022]; translation initiation factor activity [GO:0003743]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; lamin filament [GO:0005638]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005737; GO:0070062; GO:0005638; GO:0042256; GO:0005730; GO:0005654; GO:0005634; GO:0043023; GO:0042273; GO:0000054; GO:0043022; GO:0003743	SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleolus. Note=Shuttles between cytoplasm and nucleus/nucleolus.	Alternative splicing; Complete proteome; Cytoplasm; Initiation factor; Nucleus; Phosphoprotein; Protein biosynthesis; Reference proteome; Ribosome biogenesis	Alternative sequence (1); Chain (1); Modified residue (8); Sequence conflict (1)
G3V4P8_HUMAN	G3V4P8	G3V4P8_HUMAN	unreviewed	Glia maturation factor beta (Fragment)	GMFB	Homo sapiens (Human)	150	intracellular [GO:0005622]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]	negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]		intracellular [GO:0005622]	GO:0005622; GO:0034316		Complete proteome; Proteomics identification; Reference proteome	Non-terminal residue (1)
DDTL_HUMAN	A6NHG4	DDTL_HUMAN	reviewed	D-dopachrome decarboxylase-like protein (EC 4.1.1.-) (D-dopachrome tautomerase-like protein)	DDTL	Homo sapiens (Human)	134	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; lyase activity [GO:0016829]		lyase activity [GO:0016829]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]	GO:0005737; GO:0070062; GO:0016829	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.	Complete proteome; Cytoplasm; Lyase; Reference proteome	Chain (1)
MIF_HUMAN	P14174	MIF_HUMAN	reviewed	Macrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (Glycosylation-inhibiting factor) (GIF) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase)	MIF GLIF MMIF	Homo sapiens (Human)	115	cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; vesicle [GO:0031982]; chemoattractant activity [GO:0042056]; cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126]; dopachrome isomerase activity [GO:0004167]; phenylpyruvate tautomerase activity [GO:0050178]; receptor binding [GO:0005102]; carboxylic acid metabolic process [GO:0019752]; cell aging [GO:0007569]; cell proliferation [GO:0008283]; cell surface receptor signaling pathway [GO:0007166]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell aging [GO:0090344]; negative regulation of cell cycle arrest [GO:0071157]; negative regulation of cellular protein metabolic process [GO:0032269]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of gene expression [GO:0010629]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of mature B cell apoptotic process [GO:0002906]; negative regulation of myeloid cell apoptotic process [GO:0033033]; positive chemotaxis [GO:0050918]; positive regulation of arachidonic acid secretion [GO:0090238]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of cytokine secretion [GO:0050715]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of myeloid leukocyte cytokine production involved in immune response [GO:0061081]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphorylation [GO:0042327]; positive regulation of prostaglandin secretion involved in immune response [GO:0061078]; positive regulation of protein kinase A signaling [GO:0010739]; prostaglandin biosynthetic process [GO:0001516]; protein homotrimerization [GO:0070207]; regulation of macrophage activation [GO:0043030]	carboxylic acid metabolic process [GO:0019752]; cell aging [GO:0007569]; cell proliferation [GO:0008283]; cell surface receptor signaling pathway [GO:0007166]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell aging [GO:0090344]; negative regulation of cell cycle arrest [GO:0071157]; negative regulation of cellular protein metabolic process [GO:0032269]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of gene expression [GO:0010629]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of mature B cell apoptotic process [GO:0002906]; negative regulation of myeloid cell apoptotic process [GO:0033033]; positive chemotaxis [GO:0050918]; positive regulation of arachidonic acid secretion [GO:0090238]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of cytokine secretion [GO:0050715]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of myeloid leukocyte cytokine production involved in immune response [GO:0061081]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphorylation [GO:0042327]; positive regulation of prostaglandin secretion involved in immune response [GO:0061078]; positive regulation of protein kinase A signaling [GO:0010739]; prostaglandin biosynthetic process [GO:0001516]; protein homotrimerization [GO:0070207]; regulation of macrophage activation [GO:0043030]	chemoattractant activity [GO:0042056]; cytokine activity [GO:0005125]; cytokine receptor binding [GO:0005126]; dopachrome isomerase activity [GO:0004167]; phenylpyruvate tautomerase activity [GO:0050178]; receptor binding [GO:0005102]	cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; vesicle [GO:0031982]	GO:0030330; GO:0019752; GO:0007569; GO:0008283; GO:0009986; GO:0007166; GO:0042056; GO:0005125; GO:0005126; GO:0005737; GO:0004167; GO:0070062; GO:0005576; GO:0005615; GO:0006954; GO:0045087; GO:0043518; GO:0043066; GO:0090344; GO:0071157; GO:0032269; GO:0010629; GO:1902166; GO:0002906; GO:0033033; GO:0005654; GO:0050178; GO:0050918; GO:0030890; GO:0070374; GO:0043406; GO:0090238; GO:2000343; GO:0050715; GO:0048146; GO:0031666; GO:0061081; GO:0033138; GO:0050731; GO:0042327; GO:0061078; GO:0010739; GO:0001516; GO:0070207; GO:0005102; GO:0043030; GO:0031982	SUBCELLULAR LOCATION: Secreted. Cytoplasm. Note=Does not have a cleavable signal sequence and is secreted via a specialized, non-classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens.	3D-structure; Acetylation; Complete proteome; Cytokine; Cytoplasm; Direct protein sequencing; Immunity; Inflammatory response; Innate immunity; Isomerase; Reference proteome; Secreted	Active site (1); Beta strand (7); Binding site (3); Chain (1); Helix (6); Initiator methionine (1); Modified residue (2); Mutagenesis (1); Sequence conflict (6)
UBR4_HUMAN	Q5T4S7	UBR4_HUMAN	reviewed	E3 ubiquitin-protein ligase UBR4 (EC 6.3.2.-) (600 kDa retinoblastoma protein-associated factor) (N-recognin-4) (Retinoblastoma-associated factor of 600 kDa) (RBAF600) (p600) (Zinc finger UBR1-type protein 1)	UBR4 KIAA0462 KIAA1307 RBAF600 ZUBR1	Homo sapiens (Human)	5183	centrosome [GO:0005813]; cytoplasm [GO:0005737]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; ligase activity [GO:0016874]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; viral process [GO:0016032]	protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; viral process [GO:0016032]	ligase activity [GO:0016874]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]	centrosome [GO:0005813]; cytoplasm [GO:0005737]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; nucleoplasm [GO:0005654]	GO:0005813; GO:0005737; GO:0016021; GO:0016874; GO:0016020; GO:0005654; GO:0042787; GO:0004842; GO:0016032; GO:0008270	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Concentrates at the leading edge of membrane structures involved in actin motility.	Acetylation; Alternative splicing; Calmodulin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Host-virus interaction; Ligase; Membrane; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Ubl conjugation pathway; Zinc; Zinc-finger	Alternative sequence (10); Chain (1); Compositional bias (4); Erroneous gene model prediction (1); Erroneous initiation (1); Modified residue (11); Natural variant (5); Sequence conflict (4); Transmembrane (2); Zinc finger (1)
UBP10_HUMAN	Q14694	UBP10_HUMAN	reviewed	Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10)	USP10 KIAA0190	Homo sapiens (Human)	798	cytoplasm [GO:0005737]; early endosome [GO:0005769]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cysteine-type endopeptidase activity [GO:0004197]; ion channel binding [GO:0044325]; p53 binding [GO:0002039]; poly(A) RNA binding [GO:0044822]; ubiquitin-specific protease activity [GO:0004843]; autophagy [GO:0006914]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; DNA repair [GO:0006281]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; regulation of autophagy [GO:0010506]; regulation of proteasomal protein catabolic process [GO:0061136]; translesion synthesis [GO:0019985]	autophagy [GO:0006914]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; DNA repair [GO:0006281]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; regulation of autophagy [GO:0010506]; regulation of proteasomal protein catabolic process [GO:0061136]; translesion synthesis [GO:0019985]	cysteine-type endopeptidase activity [GO:0004197]; ion channel binding [GO:0044325]; p53 binding [GO:0002039]; poly(A) RNA binding [GO:0044822]; ubiquitin-specific protease activity [GO:0004843]	cytoplasm [GO:0005737]; early endosome [GO:0005769]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0030330; GO:0006281; GO:0006914; GO:0004197; GO:0005737; GO:0005769; GO:0044325; GO:0005654; GO:0005634; GO:0002039; GO:0044822; GO:0043161; GO:0016579; GO:0010506; GO:0061136; GO:0019985; GO:0004843	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Early endosome. Note=Cytoplasmic in normal conditions. After DNA damage, translocates to the nucleus following phosphorylation by ATM.	Acetylation; Alternative splicing; Autophagy; Complete proteome; Cytoplasm; DNA damage; DNA repair; Endosome; Hydrolase; Nucleus; Phosphoprotein; Polymorphism; Protease; Reference proteome; Thiol protease; Ubl conjugation; Ubl conjugation pathway	Active site (2); Alternative sequence (2); Chain (1); Domain (1); Erroneous initiation (1); Initiator methionine (1); Modified residue (11); Mutagenesis (5); Natural variant (3); Region (1); Sequence conflict (2)
PRP4_HUMAN	O43172	PRP4_HUMAN	reviewed	U4/U6 small nuclear ribonucleoprotein Prp4 (PRP4 homolog) (hPrp4) (U4/U6 snRNP 60 kDa protein) (WD splicing factor Prp4)	PRPF4 PRP4	Homo sapiens (Human)	522	Cajal body [GO:0015030]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U4/U6 snRNP [GO:0071001]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U4 snRNA binding [GO:0030621]; U6 snRNA binding [GO:0017070]; gene expression [GO:0010467]; mRNA splicing, via spliceosome [GO:0000398]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]	gene expression [GO:0010467]; mRNA splicing, via spliceosome [GO:0000398]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]	U4 snRNA binding [GO:0030621]; U6 snRNA binding [GO:0017070]	Cajal body [GO:0015030]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U4/U6 snRNP [GO:0071001]; U4/U6 x U5 tri-snRNP complex [GO:0046540]	GO:0015030; GO:0006396; GO:0008380; GO:0000375; GO:0030621; GO:0071001; GO:0046540; GO:0017070; GO:0010467; GO:0000398; GO:0016607; GO:0005654; GO:0005634; GO:0005681	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250}. Note=Colocalizes with spliceosomal snRNPs. {ECO:0000250}.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Disease mutation; Nucleus; Reference proteome; Repeat; Retinitis pigmentosa; Spliceosome; WD repeat; mRNA processing; mRNA splicing	Alternative sequence (1); Beta strand (1); Chain (1); Helix (2); Modified residue (1); Natural variant (1); Repeat (7); Sequence conflict (11)
SUMF2_HUMAN	Q8NBJ7	SUMF2_HUMAN	reviewed	Sulfatase-modifying factor 2 (C-alpha-formylglycine-generating enzyme 2)	SUMF2 PSEC0171 UNQ1968/PRO4500	Homo sapiens (Human)	301	endoplasmic reticulum lumen [GO:0005788]; metal ion binding [GO:0046872]; cellular protein metabolic process [GO:0044267]; post-translational protein modification [GO:0043687]	cellular protein metabolic process [GO:0044267]; post-translational protein modification [GO:0043687]	metal ion binding [GO:0046872]	endoplasmic reticulum lumen [GO:0005788]	GO:0044267; GO:0005788; GO:0046872; GO:0043687	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:15708861, ECO:0000269|PubMed:15962010}.	3D-structure; Alternative splicing; Calcium; Complete proteome; Direct protein sequencing; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Metal-binding; Polymorphism; Reference proteome; Signal	Alternative sequence (4); Beta strand (12); Chain (1); Disulfide bond (1); Erroneous initiation (2); Frameshift (1); Glycosylation (1); Helix (7); Metal binding (8); Mutagenesis (2); Natural variant (1); Signal peptide (1); Turn (1)
M0R0R2_HUMAN	M0R0R2	M0R0R2_HUMAN	unreviewed	40S ribosomal protein S5	RPS5	Homo sapiens (Human)	225	small ribosomal subunit [GO:0015935]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; translation [GO:0006412]	translation [GO:0006412]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	small ribosomal subunit [GO:0015935]	GO:0003723; GO:0015935; GO:0003735; GO:0006412		Complete proteome; Proteomics identification; Reference proteome; Ribonucleoprotein; Ribosomal protein	
M0R0F0_HUMAN	M0R0F0	M0R0F0_HUMAN	unreviewed	40S ribosomal protein S5 (Fragment)	RPS5	Homo sapiens (Human)	200	small ribosomal subunit [GO:0015935]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; translation [GO:0006412]	translation [GO:0006412]	RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	small ribosomal subunit [GO:0015935]	GO:0003723; GO:0015935; GO:0003735; GO:0006412		Complete proteome; Proteomics identification; Reference proteome; Ribonucleoprotein; Ribosomal protein	Non-terminal residue (1)
TE2IP_HUMAN	Q9NYB0	TE2IP_HUMAN	reviewed	Telomeric repeat-binding factor 2-interacting protein 1 (TERF2-interacting telomeric protein 1) (TRF2-interacting telomeric protein 1) (Dopamine receptor-interacting protein 5) (Repressor/activator protein 1 homolog) (RAP1 homolog) (hRap1)	TERF2IP DRIP5 RAP1 PP8000	Homo sapiens (Human)	399	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nuclear chromosome [GO:0000228]; nuclear chromosome, telomeric region [GO:0000784]; nuclear envelope [GO:0005635]; nuclear telomere cap complex [GO:0000783]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; negative regulation of DNA recombination at telomere [GO:0048239]; negative regulation of telomere maintenance [GO:0032205]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein acetylation [GO:1901985]; protection from non-homologous end joining at telomere [GO:0031848]; protein localization to chromosome, telomeric region [GO:0070198]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of transcription, DNA-templated [GO:0006355]; telomere maintenance [GO:0000723]; telomere maintenance via telomerase [GO:0007004]; telomere maintenance via telomere lengthening [GO:0010833]; transcription, DNA-templated [GO:0006351]	negative regulation of DNA recombination at telomere [GO:0048239]; negative regulation of telomere maintenance [GO:0032205]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein acetylation [GO:1901985]; protection from non-homologous end joining at telomere [GO:0031848]; protein localization to chromosome, telomeric region [GO:0070198]; regulation of double-strand break repair via homologous recombination [GO:0010569]; regulation of transcription, DNA-templated [GO:0006355]; telomere maintenance [GO:0000723]; telomere maintenance via telomerase [GO:0007004]; telomere maintenance via telomere lengthening [GO:0010833]; transcription, DNA-templated [GO:0006351]	DNA binding [GO:0003677]	chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nuclear chromosome [GO:0000228]; nuclear chromosome, telomeric region [GO:0000784]; nuclear envelope [GO:0005635]; nuclear telomere cap complex [GO:0000783]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003677; GO:0000781; GO:0005737; GO:0048239; GO:0032205; GO:0000228; GO:0000784; GO:0005635; GO:0000783; GO:0005654; GO:0005634; GO:0043123; GO:0051092; GO:0033138; GO:1901985; GO:0031848; GO:0070198; GO:0010569; GO:0006355; GO:0000723; GO:0007004; GO:0010833; GO:0006351	SUBCELLULAR LOCATION: Nucleus. Cytoplasm {ECO:0000250}. Chromosome. Chromosome, telomere. Note=Associates with chromosomes, both at telomeres and in extratelomeric sites. Also exists as a cytoplasmic form, where it associates with the IKK complex (By similarity). {ECO:0000250}.	3D-structure; Acetylation; Activator; Chromosome; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Telomere; Transcription; Transcription regulation	Beta strand (1); Chain (1); Compositional bias (1); Domain (2); Erroneous initiation (1); Erroneous termination (1); Frameshift (1); Helix (9); Initiator methionine (1); Modified residue (5); Motif (1); Natural variant (1); Sequence conflict (1); Turn (2)
H7BXH2_HUMAN	H7BXH2	H7BXH2_HUMAN	unreviewed	Serine/threonine-protein phosphatase 6 regulatory subunit 3	PPP6R3	Homo sapiens (Human)	827	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]			cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	GO:0005737; GO:0005654; GO:0005886		Complete proteome; Proteomics identification; Reference proteome	
PRP8_HUMAN	Q6P2Q9	PRP8_HUMAN	reviewed	Pre-mRNA-processing-splicing factor 8 (220 kDa U5 snRNP-specific protein) (PRP8 homolog) (Splicing factor Prp8) (p220)	PRPF8 PRPC8	Homo sapiens (Human)	2335	catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U5 snRNP [GO:0005682]; K63-linked polyubiquitin binding [GO:0070530]; poly(A) RNA binding [GO:0044822]; pre-mRNA intronic binding [GO:0097157]; second spliceosomal transesterification activity [GO:0000386]; U1 snRNA binding [GO:0030619]; U2 snRNA binding [GO:0030620]; U5 snRNA binding [GO:0030623]; U6 snRNA binding [GO:0017070]; gene expression [GO:0010467]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal tri-snRNP complex assembly [GO:0000244]	gene expression [GO:0010467]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal tri-snRNP complex assembly [GO:0000244]	K63-linked polyubiquitin binding [GO:0070530]; poly(A) RNA binding [GO:0044822]; pre-mRNA intronic binding [GO:0097157]; second spliceosomal transesterification activity [GO:0000386]; U1 snRNA binding [GO:0030619]; U2 snRNA binding [GO:0030620]; U5 snRNA binding [GO:0030623]; U6 snRNA binding [GO:0017070]	catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U5 snRNP [GO:0005682]	GO:0070530; GO:0008380; GO:0000375; GO:0030619; GO:0030620; GO:0030623; GO:0005682; GO:0017070; GO:0071013; GO:0010467; GO:0006397; GO:0000398; GO:0016020; GO:0016607; GO:0005654; GO:0005634; GO:0044822; GO:0097157; GO:0000386; GO:0000244	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250}.	3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Disease mutation; Nucleus; Phosphoprotein; Polymorphism; RNA-binding; Reference proteome; Retinitis pigmentosa; Ribonucleoprotein; Spliceosome; mRNA processing; mRNA splicing	Beta strand (11); Chain (1); Domain (1); Helix (14); Initiator methionine (1); Modified residue (3); Mutagenesis (2); Natural variant (12); Region (7); Sequence conflict (7); Turn (4)
DYN2_HUMAN	P50570	DYN2_HUMAN	reviewed	Dynamin-2 (EC 3.6.5.5)	DNM2 DYN2	Homo sapiens (Human)	870	coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; microtubule [GO:0005874]; midbody [GO:0030496]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; enzyme binding [GO:0019899]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; microtubule binding [GO:0008017]; SH3 domain binding [GO:0017124]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; endocytosis [GO:0006897]; G2/M transition of mitotic cell cycle [GO:0000086]; membrane organization [GO:0061024]; negative regulation of membrane tubulation [GO:1903526]; neuron projection morphogenesis [GO:0048812]; nitric oxide metabolic process [GO:0046209]; positive regulation of apoptotic process [GO:0043065]; positive regulation of transcription, DNA-templated [GO:0045893]; post-Golgi vesicle-mediated transport [GO:0006892]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of axon extension [GO:0030516]; regulation of nitric-oxide synthase activity [GO:0050999]; regulation of transcription, DNA-templated [GO:0006355]; signal transduction [GO:0007165]; small molecule metabolic process [GO:0044281]; synaptic vesicle transport [GO:0048489]; transferrin transport [GO:0033572]	antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; endocytosis [GO:0006897]; G2/M transition of mitotic cell cycle [GO:0000086]; membrane organization [GO:0061024]; negative regulation of membrane tubulation [GO:1903526]; neuron projection morphogenesis [GO:0048812]; nitric oxide metabolic process [GO:0046209]; positive regulation of apoptotic process [GO:0043065]; positive regulation of transcription, DNA-templated [GO:0045893]; post-Golgi vesicle-mediated transport [GO:0006892]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of axon extension [GO:0030516]; regulation of nitric-oxide synthase activity [GO:0050999]; regulation of transcription, DNA-templated [GO:0006355]; signal transduction [GO:0007165]; small molecule metabolic process [GO:0044281]; synaptic vesicle transport [GO:0048489]; transferrin transport [GO:0033572]	enzyme binding [GO:0019899]; GTPase activity [GO:0003924]; GTP binding [GO:0005525]; microtubule binding [GO:0008017]; SH3 domain binding [GO:0017124]	coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; microtubule [GO:0005874]; midbody [GO:0030496]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]	GO:0000086; GO:0005525; GO:0003924; GO:0005794; GO:0000139; GO:0017124; GO:0019886; GO:0005905; GO:0005737; GO:0005829; GO:0030666; GO:0006897; GO:0019899; GO:0070062; GO:0005925; GO:0061024; GO:0005874; GO:0008017; GO:0030496; GO:1903526; GO:0048812; GO:0046209; GO:0005886; GO:0043065; GO:0045893; GO:0006892; GO:0014069; GO:0045211; GO:0031623; GO:0006898; GO:0030516; GO:0050999; GO:0006355; GO:0007165; GO:0044281; GO:0048489; GO:0033572	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. Cell junction {ECO:0000250|UniProtKB:P39052}. Membrane, clathrin-coated pit {ECO:0000250|UniProtKB:P39052}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Midbody. Note=Colocalizes with CTTN at the basis of filopodia in hippocampus neuron growth zones (By similarity). Microtubule-associated. Also found in the postsynaptic density of neuronal cells. {ECO:0000250|UniProtKB:P39052}.	3D-structure; Acetylation; Alternative splicing; Cell junction; Cell membrane; Charcot-Marie-Tooth disease; Coated pit; Complete proteome; Cytoplasm; Cytoskeleton; Disease mutation; Endocytosis; GTP-binding; Hydrolase; Membrane; Microtubule; Motor protein; Neurodegeneration; Neuropathy; Nucleotide-binding; Phosphoprotein; Polymorphism; Postsynaptic cell membrane; Reference proteome; Synapse	Alternative sequence (3); Beta strand (9); Chain (1); Compositional bias (1); Domain (3); Helix (1); Modified residue (6); Natural variant (26); Nucleotide binding (3); Sequence conflict (5)
DNM1L_HUMAN	O00429	DNM1L_HUMAN	reviewed	Dynamin-1-like protein (EC 3.6.5.5) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-like protein) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV) (Dynamin-related protein 1)	DNM1L DLP1 DRP1	Homo sapiens (Human)	736	cell junction [GO:0030054]; coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule [GO:0005874]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; peroxisome [GO:0005777]; protein complex [GO:0043234]; synaptic vesicle membrane [GO:0030672]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; protein homodimerization activity [GO:0042803]; ubiquitin protein ligase binding [GO:0031625]; apoptotic process [GO:0006915]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; dynamin polymerization involved in mitochondrial fission [GO:0003374]; endocytosis [GO:0006897]; membrane fusion [GO:0061025]; metabolic process [GO:0008152]; mitochondrial fission [GO:0000266]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrial membrane fission [GO:0090149]; mitochondrion morphogenesis [GO:0070584]; necroptotic process [GO:0070266]; peroxisome fission [GO:0016559]; positive regulation of apoptotic process [GO:0043065]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of protein secretion [GO:0050714]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; programmed cell death [GO:0012501]; protein homotetramerization [GO:0051289]; protein localization to mitochondrion [GO:0070585]; regulation of mitochondrion degradation [GO:1903146]; regulation of mitochondrion organization [GO:0010821]; regulation of peroxisome organization [GO:1900063]; regulation of protein oligomerization [GO:0032459]; release of cytochrome c from mitochondria [GO:0001836]	apoptotic process [GO:0006915]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; dynamin polymerization involved in mitochondrial fission [GO:0003374]; endocytosis [GO:0006897]; membrane fusion [GO:0061025]; metabolic process [GO:0008152]; mitochondrial fission [GO:0000266]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrial membrane fission [GO:0090149]; mitochondrion morphogenesis [GO:0070584]; necroptotic process [GO:0070266]; peroxisome fission [GO:0016559]; positive regulation of apoptotic process [GO:0043065]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of protein secretion [GO:0050714]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; programmed cell death [GO:0012501]; protein homotetramerization [GO:0051289]; protein localization to mitochondrion [GO:0070585]; regulation of mitochondrion degradation [GO:1903146]; regulation of mitochondrion organization [GO:0010821]; regulation of peroxisome organization [GO:1900063]; regulation of protein oligomerization [GO:0032459]; release of cytochrome c from mitochondria [GO:0001836]	GTPase activity [GO:0003924]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; protein homodimerization activity [GO:0042803]; ubiquitin protein ligase binding [GO:0031625]	cell junction [GO:0030054]; coated pit [GO:0005905]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule [GO:0005874]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; peroxisome [GO:0005777]; protein complex [GO:0043234]; synaptic vesicle membrane [GO:0030672]	GO:0005525; GO:0003924; GO:0005794; GO:0006915; GO:0030054; GO:0006921; GO:0005905; GO:0005737; GO:0005829; GO:0003374; GO:0006897; GO:0042802; GO:0043231; GO:0008289; GO:0016020; GO:0061025; GO:0008152; GO:0005874; GO:0000266; GO:0043653; GO:0090149; GO:0005741; GO:0005739; GO:0070584; GO:0070266; GO:0048471; GO:0005777; GO:0016559; GO:0043065; GO:2001244; GO:0090141; GO:0050714; GO:0090200; GO:0012501; GO:0043234; GO:0042803; GO:0051289; GO:0070585; GO:1903146; GO:0010821; GO:1900063; GO:0032459; GO:0001836; GO:0030672; GO:0031625	SUBCELLULAR LOCATION: Cytoplasm, cytosol. Golgi apparatus. Endomembrane system; Peripheral membrane protein. Mitochondrion outer membrane; Peripheral membrane protein. Peroxisome. Membrane, clathrin-coated pit {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}. Note=Mainly cytosolic. Translocated to the mitochondrial membrane through O-GlcNAcylation and interaction with FIS1. Recruited to the mitochondrial outer membrane by interaction with MIEF1. Colocalized with MARCH5 at mitochondrial membrane. Localizes to mitochondria at sites of division. Localizes to mitochondria following necrosis induction. Associated with peroxisomal membranes, partly recruited there by PEX11B. May also be associated with endoplasmic reticulum tubules and cytoplasmic vesicles and found to be perinuclear. In some cell types, localizes to the Golgi complex. Binds to phospholipid membranes.	3D-structure; Acetylation; Alternative splicing; Cell junction; Coated pit; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Disease mutation; Endocytosis; GTP-binding; Glycoprotein; Golgi apparatus; Hydrolase; Isopeptide bond; Lipid-binding; Membrane; Mitochondrion; Mitochondrion outer membrane; Necrosis; Nucleotide-binding; Peroxisome; Phosphoprotein; Polymorphism; Reference proteome; S-nitrosylation; Synapse; Ubl conjugation	Alternative sequence (7); Beta strand (15); Chain (1); Cross-link (8); Domain (2); Erroneous initiation (1); Glycosylation (2); Helix (29); Modified residue (7); Mutagenesis (38); Natural variant (3); Nucleotide binding (4); Region (5); Sequence conflict (2); Turn (3)
COPG1_HUMAN	Q9Y678	COPG1_HUMAN	reviewed	Coatomer subunit gamma-1 (Gamma-1-coat protein) (Gamma-1-COP)	COPG1 COPG	Homo sapiens (Human)	874	COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; structural molecule activity [GO:0005198]; COPI coating of Golgi vesicle [GO:0048205]; establishment of Golgi localization [GO:0051683]; intracellular protein transport [GO:0006886]; membrane organization [GO:0061024]; organelle transport along microtubule [GO:0072384]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]	COPI coating of Golgi vesicle [GO:0048205]; establishment of Golgi localization [GO:0051683]; intracellular protein transport [GO:0006886]; membrane organization [GO:0061024]; organelle transport along microtubule [GO:0072384]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]	structural molecule activity [GO:0005198]	COPI vesicle coat [GO:0030126]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]	GO:0048205; GO:0030126; GO:0000139; GO:0005829; GO:0051683; GO:0006886; GO:0061024; GO:0072384; GO:0006890; GO:0005198	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11056392}. Golgi apparatus membrane {ECO:0000269|PubMed:11056392}; Peripheral membrane protein {ECO:0000269|PubMed:11056392}; Cytoplasmic side {ECO:0000269|PubMed:11056392}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Predominantly located in the cis-Golgi apparatus. {ECO:0000250}.	3D-structure; Complete proteome; Cytoplasm; Cytoplasmic vesicle; ER-Golgi transport; Golgi apparatus; Membrane; Polymorphism; Protein transport; Reference proteome; Repeat; Transport	Beta strand (14); Chain (1); Helix (6); Mutagenesis (1); Natural variant (1); Region (1); Repeat (4); Sequence conflict (5); Turn (3)
COPA_HUMAN	P53621	COPA_HUMAN	reviewed	Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEP-COP) (HEPCOP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin]	COPA	Homo sapiens (Human)	1224	COPI vesicle coat [GO:0030126]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; structural molecule activity [GO:0005198]; COPI coating of Golgi vesicle [GO:0048205]; intracellular protein transport [GO:0006886]; membrane organization [GO:0061024]; pancreatic juice secretion [GO:0030157]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]	COPI coating of Golgi vesicle [GO:0048205]; intracellular protein transport [GO:0006886]; membrane organization [GO:0061024]; pancreatic juice secretion [GO:0030157]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]	structural molecule activity [GO:0005198]	COPI vesicle coat [GO:0030126]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]	GO:0048205; GO:0030126; GO:0005737; GO:0005829; GO:0070062; GO:0005615; GO:0006886; GO:0016020; GO:0061024; GO:0030157; GO:0006890; GO:0005198	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}.; SUBCELLULAR LOCATION: Xenin: Secreted {ECO:0000250}.	Alternative splicing; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Direct protein sequencing; ER-Golgi transport; Golgi apparatus; Hormone; Membrane; Phosphoprotein; Polymorphism; Protein transport; RNA editing; Reference proteome; Repeat; Secreted; Transport; WD repeat	Alternative sequence (1); Chain (1); Modified residue (4); Natural variant (2); Peptide (2); Repeat (7); Sequence conflict (1)
CHERP_HUMAN	Q8IWX8	CHERP_HUMAN	reviewed	Calcium homeostasis endoplasmic reticulum protein (ERPROT 213-21) (SR-related CTD-associated factor 6)	CHERP DAN26 SCAF6	Homo sapiens (Human)	916	cytoplasm [GO:0005737]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; sarcoplasmic reticulum membrane [GO:0033017]; ion channel binding [GO:0044325]; poly(A) RNA binding [GO:0044822]; cellular calcium ion homeostasis [GO:0006874]; negative regulation of cell proliferation [GO:0008285]; nervous system development [GO:0007399]; positive regulation of NFAT protein import into nucleus [GO:0051533]; release of sequestered calcium ion into cytosol [GO:0051209]; RNA processing [GO:0006396]	cellular calcium ion homeostasis [GO:0006874]; negative regulation of cell proliferation [GO:0008285]; nervous system development [GO:0007399]; positive regulation of NFAT protein import into nucleus [GO:0051533]; release of sequestered calcium ion into cytosol [GO:0051209]; RNA processing [GO:0006396]	ion channel binding [GO:0044325]; poly(A) RNA binding [GO:0044822]	cytoplasm [GO:0005737]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; sarcoplasmic reticulum membrane [GO:0033017]	GO:0006396; GO:0006874; GO:0005737; GO:0044325; GO:0016020; GO:0008285; GO:0007399; GO:0048471; GO:0044822; GO:0051533; GO:0051209; GO:0033017	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10794731, ECO:0000269|PubMed:12656674, ECO:0000269|PubMed:8010949}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10794731, ECO:0000269|PubMed:12656674, ECO:0000269|PubMed:8010949}. Endoplasmic reticulum {ECO:0000269|PubMed:10794731, ECO:0000269|PubMed:12656674, ECO:0000269|PubMed:8010949}. Note=Distributed throughout the cytoplasm and also localizes to the perinuclear region of both human erythroleukemia (HEL) cells and Jurkat cells. Colocalizes with ITPR1. {ECO:0000269|PubMed:10794731, ECO:0000269|PubMed:12656674, ECO:0000269|PubMed:8010949}.	Acetylation; Complete proteome; Cytoplasm; Endoplasmic reticulum; Phosphoprotein; Polymorphism; Reference proteome	Chain (1); Compositional bias (3); Domain (2); Erroneous initiation (3); Frameshift (1); Modified residue (10); Natural variant (1); Repeat (1); Sequence conflict (9)
ANKH1_HUMAN	Q8IWZ3	ANKH1_HUMAN	reviewed	Ankyrin repeat and KH domain-containing protein 1 (HIV-1 Vpr-binding ankyrin repeat protein) (Multiple ankyrin repeats single KH domain) (hMASK)	ANKHD1 KIAA1085 MASK VBARP PP2500	Homo sapiens (Human)	2542	cytoplasm [GO:0005737]; poly(A) RNA binding [GO:0044822]		poly(A) RNA binding [GO:0044822]	cytoplasm [GO:0005737]	GO:0005737; GO:0044822	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16098192, ECO:0000269|PubMed:16956752}.	ANK repeat; Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Phosphoprotein; Polymorphism; RNA-binding; Reference proteome; Repeat	Alternative sequence (8); Chain (1); Coiled coil (2); Compositional bias (3); Domain (1); Erroneous initiation (2); Modified residue (4); Natural variant (4); Repeat (25)
H0YM23_HUMAN	H0YM23	H0YM23_HUMAN	unreviewed	Ankyrin repeat domain-containing protein 17 (Fragment)	ANKRD17	Homo sapiens (Human)	2487	RNA binding [GO:0003723]		RNA binding [GO:0003723]		GO:0003723		ANK repeat; Complete proteome; Proteomics identification; Reference proteome; Repeat	Non-terminal residue (1)
B0QZ40_HUMAN	B0QZ40	B0QZ40_HUMAN	unreviewed	COMM domain-containing protein 6	COMMD6	Homo sapiens (Human)	100							Complete proteome; Proteomics identification; Reference proteome	
A16A1_HUMAN	Q8IZ83	A16A1_HUMAN	reviewed	Aldehyde dehydrogenase family 16 member A1	ALDH16A1	Homo sapiens (Human)	802	extracellular exosome [GO:0070062]; membrane [GO:0016020]; aldehyde dehydrogenase (NAD) activity [GO:0004029]		aldehyde dehydrogenase (NAD) activity [GO:0004029]	extracellular exosome [GO:0070062]; membrane [GO:0016020]	GO:0004029; GO:0070062; GO:0016020		Alternative splicing; Complete proteome; Polymorphism; Reference proteome	Alternative sequence (3); Chain (1); Erroneous initiation (1); Erroneous translation (1); Natural variant (2)
CTBP1_HUMAN	Q13363	CTBP1_HUMAN	reviewed	C-terminal-binding protein 1 (CtBP1) (EC 1.1.1.-)	CTBP1 CTBP	Homo sapiens (Human)	440	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor complex [GO:0005667]; transcriptional repressor complex [GO:0017053]; NAD binding [GO:0051287]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; protein C-terminus binding [GO:0008022]; protein domain specific binding [GO:0019904]; repressing transcription factor binding [GO:0070491]; RNA polymerase II transcription corepressor activity [GO:0001106]; sequence-specific DNA binding transcription factor activity [GO:0003700]; transcription factor binding [GO:0008134]; Golgi organization [GO:0007030]; negative regulation of cell proliferation [GO:0008285]; negative regulation of histone acetylation [GO:0035067]; negative regulation of histone H4 acetylation [GO:0090241]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of transcription from RNA polymerase II promoter by histone modification [GO:1903758]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of histone deacetylation [GO:0031065]; protein phosphorylation [GO:0006468]; regulation of cell cycle [GO:0051726]; viral genome replication [GO:0019079]; white fat cell differentiation [GO:0050872]	Golgi organization [GO:0007030]; negative regulation of cell proliferation [GO:0008285]; negative regulation of histone acetylation [GO:0035067]; negative regulation of histone H4 acetylation [GO:0090241]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of transcription from RNA polymerase II promoter by histone modification [GO:1903758]; positive regulation of histone deacetylation [GO:0031065]; protein phosphorylation [GO:0006468]; regulation of cell cycle [GO:0051726]; viral genome replication [GO:0019079]; white fat cell differentiation [GO:0050872]	NAD binding [GO:0051287]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; protein C-terminus binding [GO:0008022]; protein domain specific binding [GO:0019904]; repressing transcription factor binding [GO:0070491]; RNA polymerase II transcription corepressor activity [GO:0001106]; sequence-specific DNA binding transcription factor activity [GO:0003700]; transcription factor binding [GO:0008134]	cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcriptional repressor complex [GO:0017053]; transcription factor complex [GO:0005667]	GO:0007030; GO:0051287; GO:0001106; GO:0005829; GO:0008285; GO:0090241; GO:0035067; GO:0000122; GO:1903758; GO:0045892; GO:0005654; GO:0005634; GO:0016616; GO:0031065; GO:0008022; GO:0019904; GO:0006468; GO:0051726; GO:0070491; GO:0003700; GO:0008134; GO:0005667; GO:0017053; GO:0019079; GO:0050872	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12679040}. Nucleus {ECO:0000269|PubMed:12679040}.	3D-structure; ADP-ribosylation; Alternative splicing; Complete proteome; Cytoplasm; Differentiation; Direct protein sequencing; Host-virus interaction; Isopeptide bond; NAD; Nucleus; Oxidoreductase; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation; Ubl conjugation	Active site (3); Alternative sequence (1); Beta strand (15); Binding site (3); Chain (1); Cross-link (1); Helix (15); Modified residue (2); Mutagenesis (15); Nucleotide binding (4); Region (2); Turn (7)
B4DNJ6_HUMAN	B4DNJ6	B4DNJ6_HUMAN		Merged into Q9Y3F4.											
ACTN4_HUMAN	O43707	ACTN4_HUMAN	reviewed	Alpha-actinin-4 (Non-muscle alpha-actinin 4)	ACTN4	Homo sapiens (Human)	911	cell-cell junction [GO:0005911]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; neuron projection [GO:0043005]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; platelet alpha granule lumen [GO:0031093]; protein complex [GO:0043234]; pseudopodium [GO:0031143]; ribonucleoprotein complex [GO:0030529]; stress fiber [GO:0001725]; Z disc [GO:0030018]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; integrin binding [GO:0005178]; ligand-dependent nuclear receptor transcription coactivator activity [GO:0030374]; nuclear hormone receptor binding [GO:0035257]; nucleoside binding [GO:0001882]; poly(A) RNA binding [GO:0044822]; protein homodimerization activity [GO:0042803]; retinoic acid receptor binding [GO:0042974]; actin filament bundle assembly [GO:0051017]; bicellular tight junction assembly [GO:0070830]; blood coagulation [GO:0007596]; negative regulation of cellular component movement [GO:0051271]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; platelet activation [GO:0030168]; platelet degranulation [GO:0002576]; positive regulation of cellular component movement [GO:0051272]; positive regulation of pinocytosis [GO:0048549]; positive regulation of sodium:proton antiporter activity [GO:0032417]; protein localization to bicellular tight junction [GO:1902396]; protein transport [GO:0015031]; regulation of apoptotic process [GO:0042981]; regulation of nucleic acid-templated transcription [GO:1903506]; response to hypoxia [GO:0001666]; retinoic acid receptor signaling pathway [GO:0048384]	actin filament bundle assembly [GO:0051017]; bicellular tight junction assembly [GO:0070830]; blood coagulation [GO:0007596]; negative regulation of cellular component movement [GO:0051271]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; platelet activation [GO:0030168]; platelet degranulation [GO:0002576]; positive regulation of cellular component movement [GO:0051272]; positive regulation of pinocytosis [GO:0048549]; positive regulation of sodium:proton antiporter activity [GO:0032417]; protein localization to bicellular tight junction [GO:1902396]; protein transport [GO:0015031]; regulation of apoptotic process [GO:0042981]; regulation of nucleic acid-templated transcription [GO:1903506]; response to hypoxia [GO:0001666]; retinoic acid receptor signaling pathway [GO:0048384]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; integrin binding [GO:0005178]; ligand-dependent nuclear receptor transcription coactivator activity [GO:0030374]; nuclear hormone receptor binding [GO:0035257]; nucleoside binding [GO:0001882]; poly(A) RNA binding [GO:0044822]; protein homodimerization activity [GO:0042803]; retinoic acid receptor binding [GO:0042974]	cell-cell junction [GO:0005911]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; neuron projection [GO:0043005]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; platelet alpha granule lumen [GO:0031093]; protein complex [GO:0043234]; pseudopodium [GO:0031143]; ribonucleoprotein complex [GO:0030529]; stress fiber [GO:0001725]; Z disc [GO:0030018]	GO:0030018; GO:0003779; GO:0051015; GO:0051017; GO:0070830; GO:0007596; GO:0005509; GO:0005911; GO:0030863; GO:0005737; GO:0070062; GO:0005576; GO:0005615; GO:0005925; GO:0005178; GO:0030374; GO:0051271; GO:0043005; GO:0035257; GO:0001882; GO:0005634; GO:0048471; GO:0035357; GO:0030168; GO:0031093; GO:0002576; GO:0044822; GO:0051272; GO:0048549; GO:0032417; GO:0043234; GO:0042803; GO:1902396; GO:0015031; GO:0031143; GO:0042981; GO:1903506; GO:0001666; GO:0042974; GO:0048384; GO:0030529; GO:0001725	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:9508771}. Cytoplasm {ECO:0000269|PubMed:22351778, ECO:0000269|PubMed:9508771}. Cell junction {ECO:0000250|UniProtKB:P57780}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Colocalizes with actin stress fibers. Nuclear translocation can be induced by the PI3 kinase inhibitor wortmannin or by cytochalasin D. Exclusively localized in the nucleus in a limited number of cell lines (breast cancer cell line MCF-7, oral floor cancer IMC-2, and bladder cancer KU-7). {ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:9508771}.	3D-structure; Acetylation; Actin-binding; Alternative splicing; Calcium; Cell junction; Complete proteome; Cytoplasm; Disease mutation; Isopeptide bond; Metal-binding; Nucleus; Phosphoprotein; Protein transport; Reference proteome; Repeat; Transport; Ubl conjugation	Alternative sequence (2); Beta strand (3); Calcium binding (2); Chain (1); Compositional bias (1); Cross-link (1); Domain (5); Erroneous initiation (1); Frameshift (1); Helix (18); Modified residue (9); Motif (1); Mutagenesis (1); Natural variant (13); Region (2); Repeat (4); Sequence conflict (13); Turn (3)
G3V3M6_HUMAN	G3V3M6	G3V3M6_HUMAN	unreviewed	DNA-(apurinic or apyrimidinic site) lyase (Fragment)	APEX1	Homo sapiens (Human)	263	centrosome [GO:0005813]; nucleus [GO:0005634]; DNA binding [GO:0003677]; double-stranded DNA 3'-5' exodeoxyribonuclease activity [GO:0008311]; endonuclease activity [GO:0004519]; base-excision repair [GO:0006284]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]	base-excision repair [GO:0006284]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]	DNA binding [GO:0003677]; double-stranded DNA 3'-5' exodeoxyribonuclease activity [GO:0008311]; endonuclease activity [GO:0004519]	centrosome [GO:0005813]; nucleus [GO:0005634]	GO:0003677; GO:0006284; GO:0005813; GO:0008311; GO:0004519; GO:0090305; GO:0005634		Complete proteome; Proteomics identification; Reference proteome	Non-terminal residue (1)
HAT1_HUMAN	O14929	HAT1_HUMAN	reviewed	Histone acetyltransferase type B catalytic subunit (EC 2.3.1.48) (Histone acetyltransferase 1)	HAT1 KAT1	Homo sapiens (Human)	419	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nuclear chromatin [GO:0000790]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein complex [GO:0043234]; H4 histone acetyltransferase activity [GO:0010485]; histone acetyltransferase activity [GO:0004402]; chromatin organization [GO:0006325]; chromatin silencing at telomere [GO:0006348]; DNA packaging [GO:0006323]; DNA replication-dependent nucleosome assembly [GO:0006335]; DNA replication-independent nucleosome assembly [GO:0006336]; histone H4 acetylation [GO:0043967]; internal protein amino acid acetylation [GO:0006475]; response to nutrient [GO:0007584]	chromatin organization [GO:0006325]; chromatin silencing at telomere [GO:0006348]; DNA packaging [GO:0006323]; DNA replication-dependent nucleosome assembly [GO:0006335]; DNA replication-independent nucleosome assembly [GO:0006336]; histone H4 acetylation [GO:0043967]; internal protein amino acid acetylation [GO:0006475]; response to nutrient [GO:0007584]	H4 histone acetyltransferase activity [GO:0010485]; histone acetyltransferase activity [GO:0004402]	cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nuclear chromatin [GO:0000790]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein complex [GO:0043234]	GO:0006323; GO:0006335; GO:0006336; GO:0010485; GO:0006325; GO:0006348; GO:0005737; GO:0043967; GO:0004402; GO:0006475; GO:0043231; GO:0000790; GO:0016363; GO:0005654; GO:0005634; GO:0043234; GO:0007584	SUBCELLULAR LOCATION: Isoform A: Nucleus matrix.; SUBCELLULAR LOCATION: Isoform B: Cytoplasm. Nucleus. Nucleus matrix. Nucleus, nucleoplasm. Note=Localization is predominantly nuclear in normal cells. Treatment with hydrogen peroxide or ionizing radiation enhances nuclear localization through redistribution of existing protein.	3D-structure; Acetylation; Acyltransferase; Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Polymorphism; Reference proteome; Transferase	Active site (1); Alternative sequence (1); Beta strand (13); Chain (1); Erroneous initiation (1); Helix (15); Initiator methionine (1); Modified residue (3); Mutagenesis (6); Natural variant (1); Region (4); Site (1); Turn (4)
H0YEG8_HUMAN	H0YEG8	H0YEG8_HUMAN	unreviewed	Nucleobindin-2 (Fragment)	NUCB2	Homo sapiens (Human)	198	calcium ion binding [GO:0005509]		calcium ion binding [GO:0005509]		GO:0005509		Calcium; Complete proteome; Proteomics identification; Reference proteome	Non-terminal residue (1)
GLYM_HUMAN	P34897	GLYM_HUMAN	reviewed	Serine hydroxymethyltransferase, mitochondrial (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase)	SHMT2	Homo sapiens (Human)	504	extracellular exosome [GO:0070062]; microtubule cytoskeleton [GO:0015630]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; amino acid binding [GO:0016597]; chromatin binding [GO:0003682]; glycine hydroxymethyltransferase activity [GO:0004372]; L-allo-threonine aldolase activity [GO:0008732]; pyridoxal phosphate binding [GO:0030170]; glycine biosynthetic process from serine [GO:0019264]; L-serine biosynthetic process [GO:0006564]; one-carbon metabolic process [GO:0006730]; positive regulation of cell proliferation [GO:0008284]; protein homotetramerization [GO:0051289]; tetrahydrofolate interconversion [GO:0035999]	glycine biosynthetic process from serine [GO:0019264]; L-serine biosynthetic process [GO:0006564]; one-carbon metabolic process [GO:0006730]; positive regulation of cell proliferation [GO:0008284]; protein homotetramerization [GO:0051289]; tetrahydrofolate interconversion [GO:0035999]	amino acid binding [GO:0016597]; chromatin binding [GO:0003682]; glycine hydroxymethyltransferase activity [GO:0004372]; L-allo-threonine aldolase activity [GO:0008732]; pyridoxal phosphate binding [GO:0030170]	extracellular exosome [GO:0070062]; microtubule cytoskeleton [GO:0015630]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]	GO:0008732; GO:0006564; GO:0016597; GO:0003682; GO:0070062; GO:0019264; GO:0004372; GO:0015630; GO:0005743; GO:0005758; GO:0005759; GO:0042645; GO:0005739; GO:0006730; GO:0008284; GO:0051289; GO:0030170; GO:0035999	SUBCELLULAR LOCATION: Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid. Mitochondrion inner membrane.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Membrane; Mitochondrion; Mitochondrion inner membrane; Mitochondrion nucleoid; One-carbon metabolism; Pyridoxal phosphate; Reference proteome; Transferase; Transit peptide	Alternative sequence (2); Beta strand (16); Chain (1); Helix (24); Modified residue (9); Sequence conflict (1); Transit peptide (1); Turn (3)
PP1R7_HUMAN	Q15435	PP1R7_HUMAN	reviewed	Protein phosphatase 1 regulatory subunit 7 (Protein phosphatase 1 regulatory subunit 22)	PPP1R7 SDS22	Homo sapiens (Human)	360	chromosome [GO:0005694]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; enzyme regulator activity [GO:0030234]; protein phosphatase type 1 regulator activity [GO:0008599]; chromosome segregation [GO:0007059]; positive regulation of protein dephosphorylation [GO:0035307]; regulation of catalytic activity [GO:0050790]	chromosome segregation [GO:0007059]; positive regulation of protein dephosphorylation [GO:0035307]; regulation of catalytic activity [GO:0050790]	enzyme regulator activity [GO:0030234]; protein phosphatase type 1 regulator activity [GO:0008599]	chromosome [GO:0005694]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	GO:0005694; GO:0007059; GO:0005737; GO:0030234; GO:0070062; GO:0005634; GO:0035307; GO:0008599; GO:0050790	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.	Acetylation; Alternative splicing; Complete proteome; Leucine-rich repeat; Nucleus; Phosphoprotein; Reference proteome; Repeat	Alternative sequence (4); Chain (1); Domain (1); Initiator methionine (1); Modified residue (6); Mutagenesis (8); Repeat (11)
SRS10_HUMAN	O75494	SRS10_HUMAN	reviewed	Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein)	SRSF10 FUSIP1 FUSIP2 SFRS13A TASR	Homo sapiens (Human)	262	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; RS domain binding [GO:0050733]; unfolded protein binding [GO:0051082]; cytoplasmic transport [GO:0016482]; mRNA export from nucleus [GO:0006406]; mRNA splice site selection [GO:0006376]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; regulation of transcription, DNA-templated [GO:0006355]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal tri-snRNP complex assembly [GO:0000244]	cytoplasmic transport [GO:0016482]; mRNA export from nucleus [GO:0006406]; mRNA splice site selection [GO:0006376]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; regulation of transcription, DNA-templated [GO:0006355]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal tri-snRNP complex assembly [GO:0000244]	nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; RS domain binding [GO:0050733]; unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0003723; GO:0000375; GO:0050733; GO:0005737; GO:0016482; GO:0006406; GO:0006376; GO:0000398; GO:0048025; GO:0016607; GO:0005654; GO:0000166; GO:0005634; GO:0044822; GO:0006355; GO:0000244; GO:0051082	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:11684676}. Cytoplasm {ECO:0000269|PubMed:11684676}.	Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; RNA-binding; Reference proteome; mRNA processing; mRNA splicing	Alternative sequence (7); Chain (1); Compositional bias (1); Domain (1); Modified residue (7)
RN114_HUMAN	Q9Y508	RN114_HUMAN	reviewed	E3 ubiquitin-protein ligase RNF114 (EC 6.3.2.-) (RING finger protein 114) (Zinc finger protein 228) (Zinc finger protein 313)	RNF114 ZNF228 ZNF313	Homo sapiens (Human)	228	cytoplasm [GO:0005737]; intracellular [GO:0005622]; nucleus [GO:0005634]; ligase activity [GO:0016874]; zinc ion binding [GO:0008270]; cell differentiation [GO:0030154]; multicellular organismal development [GO:0007275]; protein ubiquitination [GO:0016567]; spermatogenesis [GO:0007283]	cell differentiation [GO:0030154]; multicellular organismal development [GO:0007275]; protein ubiquitination [GO:0016567]; spermatogenesis [GO:0007283]	ligase activity [GO:0016874]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; intracellular [GO:0005622]; nucleus [GO:0005634]	GO:0030154; GO:0005737; GO:0005622; GO:0016874; GO:0007275; GO:0005634; GO:0016567; GO:0007283; GO:0008270	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23645206}. Nucleus {ECO:0000269|PubMed:23645206}.	Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Ligase; Metal-binding; Nucleus; Reference proteome; Spermatogenesis; Ubl conjugation; Ubl conjugation pathway; Zinc; Zinc-finger	Alternative sequence (2); Chain (1); Erroneous initiation (1); Modified residue (2); Sequence conflict (4); Zinc finger (1)
ERC6L_HUMAN	Q2NKX8	ERC6L_HUMAN	reviewed	DNA excision repair protein ERCC-6-like (EC 3.6.4.12) (ATP-dependent helicase ERCC6-like) (PLK1-interacting checkpoint helicase) (Tumor antigen BJ-HCC-15)	ERCC6L PICH	Homo sapiens (Human)	1250	centrosome [GO:0005813]; condensed chromosome kinetochore [GO:0000777]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; cell division [GO:0051301]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; small GTPase mediated signal transduction [GO:0007264]	cell division [GO:0051301]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; small GTPase mediated signal transduction [GO:0007264]	ATP binding [GO:0005524]; DNA binding [GO:0003677]; helicase activity [GO:0004386]	centrosome [GO:0005813]; condensed chromosome kinetochore [GO:0000777]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]	GO:0005524; GO:0003677; GO:0051301; GO:0005813; GO:0000777; GO:0005737; GO:0005829; GO:0004386; GO:0016020; GO:0000278; GO:0007067; GO:0005654; GO:0005886; GO:0007264	SUBCELLULAR LOCATION: Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores, inner centromeres and thin threads connecting separating chromosomes even during anaphase. In prometaphase cells, it mostly concentrates in between kinetochores. In metaphase, it localizes to numerous thin threads that stretch between sister kinetochores of the aligned chromosomes and are composed of catenated centromeric DNA. Evolution from inner centromeres to thin threads takes place in response to tension. Resolution of thin threads requires topoisomerase 2-alpha (TOP2A) after anaphase onset.	ATP-binding; Cell cycle; Cell division; Centromere; Chromosome; Complete proteome; DNA-binding; Helicase; Hydrolase; Kinetochore; Mitosis; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; TPR repeat	Chain (1); Domain (2); Erroneous termination (2); Modified residue (14); Motif (1); Mutagenesis (2); Nucleotide binding (1); Repeat (2); Sequence conflict (7)
EIF3I_HUMAN	Q13347	EIF3I_HUMAN	reviewed	Eukaryotic translation initiation factor 3 subunit I (eIF3i) (Eukaryotic translation initiation factor 3 subunit 2) (TGF-beta receptor-interacting protein 1) (TRIP-1) (eIF-3-beta) (eIF3 p36)	EIF3I EIF3S2 TRIP1	Homo sapiens (Human)	325	cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; extracellular exosome [GO:0070062]; translation initiation factor activity [GO:0003743]; cellular protein metabolic process [GO:0044267]; formation of translation preinitiation complex [GO:0001731]; gene expression [GO:0010467]; regulation of translational initiation [GO:0006446]; translation [GO:0006412]; translational initiation [GO:0006413]	cellular protein metabolic process [GO:0044267]; formation of translation preinitiation complex [GO:0001731]; gene expression [GO:0010467]; regulation of translational initiation [GO:0006446]; translation [GO:0006412]; translational initiation [GO:0006413]	translation initiation factor activity [GO:0003743]	cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; eukaryotic translation initiation factor 3 complex, eIF3m [GO:0071541]; extracellular exosome [GO:0070062]	GO:0044267; GO:0005829; GO:0016282; GO:0033290; GO:0005852; GO:0071541; GO:0070062; GO:0001731; GO:0010467; GO:0006446; GO:0006412; GO:0003743; GO:0006413	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03008}.	Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Initiation factor; Isopeptide bond; Phosphoprotein; Protein biosynthesis; Reference proteome; Repeat; Ubl conjugation; WD repeat	Chain (1); Cross-link (1); Mass spectrometry (2); Modified residue (2); Repeat (7)
DHX37_HUMAN	Q8IY37	DHX37_HUMAN	reviewed	Probable ATP-dependent RNA helicase DHX37 (EC 3.6.4.13) (DEAH box protein 37)	DHX37 DDX37 KIAA1517	Homo sapiens (Human)	1157	cytoplasm [GO:0005737]; nucleolus [GO:0005730]; ATP binding [GO:0005524]; ATP-dependent RNA helicase activity [GO:0004004]; poly(A) RNA binding [GO:0044822]; RNA processing [GO:0006396]	RNA processing [GO:0006396]	ATP binding [GO:0005524]; ATP-dependent RNA helicase activity [GO:0004004]; poly(A) RNA binding [GO:0044822]	cytoplasm [GO:0005737]; nucleolus [GO:0005730]	GO:0005524; GO:0004004; GO:0006396; GO:0005737; GO:0005730; GO:0044822		ATP-binding; Complete proteome; Helicase; Hydrolase; Nucleotide-binding; Polymorphism; Reference proteome	Chain (1); Domain (2); Motif (1); Natural variant (6); Nucleotide binding (1); Sequence conflict (3)
ACTN1_HUMAN	P12814	ACTN1_HUMAN	reviewed	Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1)	ACTN1	Homo sapiens (Human)	892	cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fascia adherens [GO:0005916]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]; pseudopodium [GO:0031143]; ruffle [GO:0001726]; stress fiber [GO:0001725]; Z disc [GO:0030018]; calcium ion binding [GO:0005509]; double-stranded RNA binding [GO:0003725]; integrin binding [GO:0005178]; ion channel binding [GO:0044325]; ligand-dependent nuclear receptor transcription coactivator activity [GO:0030374]; vinculin binding [GO:0017166]; actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; actin filament network formation [GO:0051639]; actin filament organization [GO:0007015]; blood coagulation [GO:0007596]; cell junction assembly [GO:0034329]; extracellular matrix organization [GO:0030198]; focal adhesion assembly [GO:0048041]; negative regulation of cellular component movement [GO:0051271]; platelet activation [GO:0030168]; platelet degranulation [GO:0002576]; platelet formation [GO:0030220]; platelet morphogenesis [GO:0036344]; regulation of apoptotic process [GO:0042981]; regulation of nucleic acid-templated transcription [GO:1903506]	actin crosslink formation [GO:0051764]; actin filament bundle assembly [GO:0051017]; actin filament network formation [GO:0051639]; actin filament organization [GO:0007015]; blood coagulation [GO:0007596]; cell junction assembly [GO:0034329]; extracellular matrix organization [GO:0030198]; focal adhesion assembly [GO:0048041]; negative regulation of cellular component movement [GO:0051271]; platelet activation [GO:0030168]; platelet degranulation [GO:0002576]; platelet formation [GO:0030220]; platelet morphogenesis [GO:0036344]; regulation of apoptotic process [GO:0042981]; regulation of nucleic acid-templated transcription [GO:1903506]	calcium ion binding [GO:0005509]; double-stranded RNA binding [GO:0003725]; integrin binding [GO:0005178]; ion channel binding [GO:0044325]; ligand-dependent nuclear receptor transcription coactivator activity [GO:0030374]; vinculin binding [GO:0017166]	cell projection [GO:0042995]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; fascia adherens [GO:0005916]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]; pseudopodium [GO:0031143]; ruffle [GO:0001726]; stress fiber [GO:0001725]; Z disc [GO:0030018]	GO:0030018; GO:0051764; GO:0051017; GO:0051639; GO:0007015; GO:0007596; GO:0005509; GO:0034329; GO:0042995; GO:0030864; GO:0005737; GO:0005829; GO:0043197; GO:0003725; GO:0070062; GO:0030198; GO:0005576; GO:0005615; GO:0005916; GO:0005925; GO:0048041; GO:0005178; GO:0044325; GO:0030374; GO:0051271; GO:0005634; GO:0005886; GO:0030168; GO:0031093; GO:0002576; GO:0030220; GO:0036344; GO:0031143; GO:0042981; GO:1903506; GO:0001726; GO:0001725; GO:0017166	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:24069336, ECO:0000269|PubMed:7750553}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:7750553}. Cell membrane {ECO:0000250}. Cell junction {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Note=Colocalizes with MYOZ2 and PPP3CA at the Z-line of heart and skeletal muscle. Colocalizes with PSD in membrane ruffles and central reticular structures (By similarity). {ECO:0000250}.	3D-structure; Acetylation; Actin-binding; Alternative splicing; Calcium; Cell junction; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Disease mutation; Membrane; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat	Alternative sequence (3); Beta strand (2); Calcium binding (2); Chain (1); Domain (5); Helix (14); Modified residue (10); Natural variant (9); Region (1); Repeat (4); Sequence conflict (8); Turn (2)
DBLOH_HUMAN	Q9NR28	DBLOH_HUMAN	reviewed	Diablo homolog, mitochondrial (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac)	DIABLO SMAC	Homo sapiens (Human)	239	CD40 receptor complex [GO:0035631]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635]; apoptotic process [GO:0006915]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; neuron apoptotic process [GO:0051402]; positive regulation of apoptotic process [GO:0043065]; programmed cell death [GO:0012501]	activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635]; apoptotic process [GO:0006915]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; neuron apoptotic process [GO:0051402]; positive regulation of apoptotic process [GO:0043065]; programmed cell death [GO:0012501]		CD40 receptor complex [GO:0035631]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]	GO:0035631; GO:0006919; GO:0008635; GO:0006915; GO:0009898; GO:0005829; GO:0008625; GO:0097193; GO:0008631; GO:0005758; GO:0005739; GO:0051402; GO:0043065; GO:0012501	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:14523016}. Note=Released into the cytosol when cells undergo apoptosis.	3D-structure; Alternative splicing; Apoptosis; Complete proteome; Deafness; Direct protein sequencing; Disease mutation; Mitochondrion; Non-syndromic deafness; Reference proteome; Transit peptide; Ubl conjugation	Alternative sequence (2); Beta strand (1); Chain (1); Helix (3); Motif (1); Natural variant (1); Sequence conflict (3); Transit peptide (1); Turn (1)
RANB9_HUMAN	Q96S59	RANB9_HUMAN	reviewed	Ran-binding protein 9 (RanBP9) (BPM-L) (BPM90) (Ran-binding protein M) (RanBPM) (RanBP7)	RANBP9 RANBPM	Homo sapiens (Human)	729	cytosol [GO:0005829]; microtubule associated complex [GO:0005875]; nucleus [GO:0005634]; enzyme binding [GO:0019899]; Ran GTPase binding [GO:0008536]; axon guidance [GO:0007411]; microtubule nucleation [GO:0007020]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; protein complex assembly [GO:0006461]	axon guidance [GO:0007411]; microtubule nucleation [GO:0007020]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; protein complex assembly [GO:0006461]	enzyme binding [GO:0019899]; Ran GTPase binding [GO:0008536]	cytosol [GO:0005829]; microtubule associated complex [GO:0005875]; nucleus [GO:0005634]	GO:0008536; GO:0007411; GO:0005829; GO:0019899; GO:0005875; GO:0007020; GO:0070373; GO:0005634; GO:0006461	SUBCELLULAR LOCATION: Cytoplasm, cytosol. Nucleus. Note==Predominantly cytoplasmic. A phosphorylated form is associated with the plasma membrane.	Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation	Alternative sequence (2); Chain (1); Compositional bias (7); Domain (3); Erroneous initiation (2); Frameshift (1); Modified residue (2); Region (2); Sequence caution (1); Sequence conflict (1)
BICD2_HUMAN	Q8TD16	BICD2_HUMAN	reviewed	Protein bicaudal D homolog 2 (Bic-D 2)	BICD2 KIAA0699	Homo sapiens (Human)	824	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; Rab GTPase binding [GO:0017137]; microtubule anchoring at microtubule organizing center [GO:0072393]; minus-end-directed organelle transport along microtubule [GO:0072385]	microtubule anchoring at microtubule organizing center [GO:0072393]; minus-end-directed organelle transport along microtubule [GO:0072385]	Rab GTPase binding [GO:0017137]	cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]	GO:0005794; GO:0017137; GO:0005737; GO:0031410; GO:0005856; GO:0072393; GO:0072385; GO:0005886	SUBCELLULAR LOCATION: Golgi apparatus. Cytoplasm, cytoskeleton. Note=In interphase cells mainly localizes to the Golgi complex and colocalizes with dynactin at microtubule plus ends (By similarity). Its localization is dependent on microtubule morphology. {ECO:0000250}.	Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Disease mutation; Golgi apparatus; Neurodegeneration; Phosphoprotein; Reference proteome	Alternative sequence (1); Chain (1); Coiled coil (3); Erroneous initiation (1); Initiator methionine (1); Modified residue (8); Natural variant (8); Region (1)
EIF3L_HUMAN	Q9Y262	EIF3L_HUMAN	reviewed	Eukaryotic translation initiation factor 3 subunit L (eIF3l) (Eukaryotic translation initiation factor 3 subunit 6-interacting protein) (Eukaryotic translation initiation factor 3 subunit E-interacting protein)	EIF3L EIF3EIP EIF3S6IP HSPC021 HSPC025 MSTP005	Homo sapiens (Human)	564	eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; poly(A) RNA binding [GO:0044822]; translation initiation factor activity [GO:0003743]; formation of translation preinitiation complex [GO:0001731]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413]	formation of translation preinitiation complex [GO:0001731]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413]	poly(A) RNA binding [GO:0044822]; translation initiation factor activity [GO:0003743]	eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; fibrillar center [GO:0001650]; membrane [GO:0016020]; nucleoplasm [GO:0005654]	GO:0016282; GO:0033290; GO:0005852; GO:0001650; GO:0001731; GO:0016020; GO:0005654; GO:0044822; GO:0006446; GO:0003743; GO:0006413	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03011}.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Initiation factor; Phosphoprotein; Polymorphism; Protein biosynthesis; Reference proteome	Alternative sequence (1); Chain (1); Erroneous initiation (2); Initiator methionine (1); Mass spectrometry (2); Modified residue (4); Natural variant (1); Sequence conflict (7)
RFC1_HUMAN	P35251	RFC1_HUMAN	reviewed	Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit)	RFC1 RFC140	Homo sapiens (Human)	1148	cell junction [GO:0030054]; DNA replication factor C complex [GO:0005663]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; double-stranded DNA binding [GO:0003690]; enzyme activator activity [GO:0008047]; sequence-specific DNA binding [GO:0043565]; base-excision repair [GO:0006284]; DNA damage response, detection of DNA damage [GO:0042769]; DNA repair [GO:0006281]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA-dependent DNA replication [GO:0006261]; error-free translesion synthesis [GO:0070987]; error-prone translesion synthesis [GO:0042276]; mitotic cell cycle [GO:0000278]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair, DNA gap filling [GO:0006297]; positive regulation of catalytic activity [GO:0043085]; positive regulation of transcription, DNA-templated [GO:0045893]; telomere maintenance [GO:0000723]; telomere maintenance via recombination [GO:0000722]; telomere maintenance via semi-conservative replication [GO:0032201]; telomere maintenance via telomerase [GO:0007004]; transcription, DNA-templated [GO:0006351]; transcription-coupled nucleotide-excision repair [GO:0006283]; translesion synthesis [GO:0019985]	base-excision repair [GO:0006284]; DNA damage response, detection of DNA damage [GO:0042769]; DNA-dependent DNA replication [GO:0006261]; DNA repair [GO:0006281]; DNA strand elongation involved in DNA replication [GO:0006271]; error-free translesion synthesis [GO:0070987]; error-prone translesion synthesis [GO:0042276]; mitotic cell cycle [GO:0000278]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair, DNA gap filling [GO:0006297]; positive regulation of catalytic activity [GO:0043085]; positive regulation of transcription, DNA-templated [GO:0045893]; telomere maintenance [GO:0000723]; telomere maintenance via recombination [GO:0000722]; telomere maintenance via semi-conservative replication [GO:0032201]; telomere maintenance via telomerase [GO:0007004]; transcription, DNA-templated [GO:0006351]; transcription-coupled nucleotide-excision repair [GO:0006283]; translesion synthesis [GO:0019985]	ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA clamp loader activity [GO:0003689]; double-stranded DNA binding [GO:0003690]; enzyme activator activity [GO:0008047]; sequence-specific DNA binding [GO:0043565]	cell junction [GO:0030054]; DNA replication factor C complex [GO:0005663]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005524; GO:0003677; GO:0003689; GO:0042769; GO:0006281; GO:0005663; GO:0006271; GO:0006261; GO:0005794; GO:0006284; GO:0030054; GO:0003690; GO:0008047; GO:0070987; GO:0042276; GO:0070062; GO:0000278; GO:0000122; GO:0005730; GO:0005654; GO:0006289; GO:0006297; GO:0005634; GO:0043085; GO:0045893; GO:0043565; GO:0000723; GO:0000722; GO:0032201; GO:0007004; GO:0006351; GO:0006283; GO:0019985	SUBCELLULAR LOCATION: Nucleus.	3D-structure; ATP-binding; Activator; Alternative splicing; Complete proteome; DNA replication; DNA-binding; Direct protein sequencing; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation	Alternative sequence (1); Beta strand (6); Chain (1); Domain (1); Helix (4); Modified residue (18); Motif (1); Natural variant (5); Nucleotide binding (1); Sequence conflict (14); Turn (1)
PSME1_HUMAN	Q06323	PSME1_HUMAN	reviewed	Proteasome activator complex subunit 1 (11S regulator complex subunit alpha) (REG-alpha) (Activator of multicatalytic protease subunit 1) (Interferon gamma up-regulated I-5111 protein) (IGUP I-5111) (Proteasome activator 28 subunit alpha) (PA28a) (PA28alpha)	PSME1 IFI5111	Homo sapiens (Human)	249	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; proteasome activator complex [GO:0008537]; proteasome complex [GO:0000502]; endopeptidase activator activity [GO:0061133]; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	endopeptidase activator activity [GO:0061133]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; proteasome activator complex [GO:0008537]; proteasome complex [GO:0000502]	GO:0006977; GO:0000082; GO:0031145; GO:0042590; GO:0002479; GO:0002474; GO:0006915; GO:0034641; GO:0005737; GO:0005829; GO:0061133; GO:0070062; GO:0010467; GO:0045087; GO:0000278; GO:0043066; GO:0090090; GO:0051436; GO:0005654; GO:0090263; GO:0051437; GO:0012501; GO:0008537; GO:0000502; GO:0000209; GO:0042981; GO:0006521; GO:0051439; GO:0044281; GO:0002223; GO:0016032		3D-structure; Alternative splicing; Complete proteome; Direct protein sequencing; Polymorphism; Proteasome; Reference proteome	Alternative sequence (3); Chain (1); Helix (7); Natural variant (2)
Q5VZU9_HUMAN	Q5VZU9	Q5VZU9_HUMAN	unreviewed	Tripeptidyl-peptidase 2	TPP2	Homo sapiens (Human)	1262	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; serine-type endopeptidase activity [GO:0004252]		serine-type endopeptidase activity [GO:0004252]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005737; GO:0005654; GO:0005634; GO:0004252		Complete proteome; Proteomics identification; Reference proteome	
SATB1_HUMAN	Q01826	SATB1_HUMAN	reviewed	DNA-binding protein SATB1 (Special AT-rich sequence-binding protein 1)	SATB1	Homo sapiens (Human)	763	nuclear heterochromatin [GO:0005720]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; chromatin binding [GO:0003682]; double-stranded DNA binding [GO:0003690]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [GO:0001227]; activated T cell proliferation [GO:0050798]; apoptotic process [GO:0006915]; CD4-positive, alpha-beta T cell differentiation [GO:0043367]; CD8-positive, alpha-beta T cell differentiation [GO:0043374]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; epidermis development [GO:0008544]; histone methylation [GO:0016571]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; programmed cell death [GO:0012501]; reflex [GO:0060004]; viral process [GO:0016032]	activated T cell proliferation [GO:0050798]; apoptotic process [GO:0006915]; CD4-positive, alpha-beta T cell differentiation [GO:0043367]; CD8-positive, alpha-beta T cell differentiation [GO:0043374]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; epidermis development [GO:0008544]; histone methylation [GO:0016571]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; programmed cell death [GO:0012501]; reflex [GO:0060004]; viral process [GO:0016032]	chromatin binding [GO:0003682]; double-stranded DNA binding [GO:0003690]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [GO:0001227]	nuclear heterochromatin [GO:0005720]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	GO:0043367; GO:0043374; GO:0016605; GO:0000977; GO:0001227; GO:0050798; GO:0006915; GO:0006921; GO:0003682; GO:0006325; GO:0006338; GO:0003690; GO:0008544; GO:0016571; GO:0000122; GO:0005720; GO:0016363; GO:0005654; GO:0005634; GO:0012501; GO:0060004; GO:0016032	SUBCELLULAR LOCATION: Nucleus matrix. Nucleus, PML body. Note=Organized into a cage-like network anchoring loops of heterochromatin and tethering specialized DNA sequences. When sumoylated, localized in promyelocytic leukemia nuclear bodies (PML NBs).	3D-structure; Acetylation; Alternative splicing; Chromatin regulator; Chromosomal rearrangement; Complete proteome; DNA-binding; Homeobox; Host-virus interaction; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Ubl conjugation	Alternative sequence (1); Beta strand (5); Binding site (2); Chain (1); Compositional bias (2); Cross-link (1); DNA binding (3); Erroneous initiation (1); Helix (16); Modified residue (2); Motif (2); Mutagenesis (27); Region (3); Site (1); Turn (2)
RFA1_HUMAN	P27694	RFA1_HUMAN	reviewed	Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]	RPA1 REPA1 RPA70	Homo sapiens (Human)	616	DNA replication factor A complex [GO:0005662]; lateral element [GO:0000800]; male germ cell nucleus [GO:0001673]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; metal ion binding [GO:0046872]; single-stranded DNA binding [GO:0003697]; base-excision repair [GO:0006284]; cell cycle checkpoint [GO:0000075]; cellular protein metabolic process [GO:0044267]; cellular response to heat [GO:0034605]; DNA damage response, detection of DNA damage [GO:0042769]; DNA recombinase assembly [GO:0000730]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA-dependent DNA replication [GO:0006261]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; error-free translesion synthesis [GO:0070987]; error-prone translesion synthesis [GO:0042276]; G1/S transition of mitotic cell cycle [GO:0000082]; hemopoiesis [GO:0030097]; homeostasis of number of cells within a tissue [GO:0048873]; in utero embryonic development [GO:0001701]; meiotic nuclear division [GO:0007126]; mismatch repair [GO:0006298]; mitotic cell cycle [GO:0000278]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair, DNA damage removal [GO:0000718]; nucleotide-excision repair, DNA gap filling [GO:0006297]; positive regulation of cell proliferation [GO:0008284]; post-translational protein modification [GO:0043687]; protein sumoylation [GO:0016925]; regulation of cellular response to heat [GO:1900034]; telomere maintenance [GO:0000723]; telomere maintenance via recombination [GO:0000722]; telomere maintenance via semi-conservative replication [GO:0032201]; transcription-coupled nucleotide-excision repair [GO:0006283]; translesion synthesis [GO:0019985]	base-excision repair [GO:0006284]; cell cycle checkpoint [GO:0000075]; cellular protein metabolic process [GO:0044267]; cellular response to heat [GO:0034605]; DNA damage response, detection of DNA damage [GO:0042769]; DNA-dependent DNA replication [GO:0006261]; DNA recombinase assembly [GO:0000730]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA strand elongation involved in DNA replication [GO:0006271]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; error-free translesion synthesis [GO:0070987]; error-prone translesion synthesis [GO:0042276]; G1/S transition of mitotic cell cycle [GO:0000082]; hemopoiesis [GO:0030097]; homeostasis of number of cells within a tissue [GO:0048873]; in utero embryonic development [GO:0001701]; meiotic nuclear division [GO:0007126]; mismatch repair [GO:0006298]; mitotic cell cycle [GO:0000278]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair, DNA damage removal [GO:0000718]; nucleotide-excision repair, DNA gap filling [GO:0006297]; positive regulation of cell proliferation [GO:0008284]; post-translational protein modification [GO:0043687]; protein sumoylation [GO:0016925]; regulation of cellular response to heat [GO:1900034]; telomere maintenance [GO:0000723]; telomere maintenance via recombination [GO:0000722]; telomere maintenance via semi-conservative replication [GO:0032201]; transcription-coupled nucleotide-excision repair [GO:0006283]; translesion synthesis [GO:0019985]	chromatin binding [GO:0003682]; damaged DNA binding [GO:0003684]; metal ion binding [GO:0046872]; single-stranded DNA binding [GO:0003697]	DNA replication factor A complex [GO:0005662]; lateral element [GO:0000800]; male germ cell nucleus [GO:0001673]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]	GO:0042769; GO:0000730; GO:0006310; GO:0006281; GO:0006260; GO:0005662; GO:0006271; GO:0006261; GO:0000082; GO:0016605; GO:0006284; GO:0000075; GO:0044267; GO:0034605; GO:0003682; GO:0003684; GO:0006302; GO:0000724; GO:0070987; GO:0042276; GO:0030097; GO:0048873; GO:0001701; GO:0000800; GO:0001673; GO:0007126; GO:0046872; GO:0006298; GO:0000278; GO:0005654; GO:0006289; GO:0000718; GO:0006297; GO:0005634; GO:0008284; GO:0043687; GO:0016925; GO:1900034; GO:0003697; GO:0000723; GO:0000722; GO:0032201; GO:0006283; GO:0019985	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17959650}. Nucleus, PML body {ECO:0000269|PubMed:17959650}. Note=Enriched in PML bodies in cells displaying alternative lengthening of their telomeres. {ECO:0000269|PubMed:17959650}.	3D-structure; Acetylation; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA replication; DNA-binding; Direct protein sequencing; Isopeptide bond; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation; Zinc; Zinc-finger	Beta strand (34); Chain (2); Cross-link (2); DNA binding (1); Erroneous initiation (1); Helix (17); Initiator methionine (1); Modified residue (7); Mutagenesis (6); Natural variant (1); Turn (7); Zinc finger (1)
ARGL1_HUMAN	Q9NWB6	ARGL1_HUMAN	reviewed	Arginine and glutamate-rich protein 1	ARGLU1	Homo sapiens (Human)	273	mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]	regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]		mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	GO:0005739; GO:0005654; GO:0006355; GO:0006351	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21454576}. Note=Recruited, in an estrogen-dependent manner, to ESR1 target gene promoters. Colocalizes with MED1.	Alternative splicing; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation	Alternative sequence (2); Chain (1); Compositional bias (2); Erroneous gene model prediction (1); Modified residue (4)
PRC2C_HUMAN	Q9Y520	PRC2C_HUMAN	reviewed	Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C)	PRRC2C BAT2D1 BAT2L2 KIAA1096 XTP2	Homo sapiens (Human)	2896	membrane [GO:0016020]; poly(A) RNA binding [GO:0044822]; protein C-terminus binding [GO:0008022]; hematopoietic progenitor cell differentiation [GO:0002244]	hematopoietic progenitor cell differentiation [GO:0002244]	poly(A) RNA binding [GO:0044822]; protein C-terminus binding [GO:0008022]	membrane [GO:0016020]	GO:0002244; GO:0016020; GO:0044822; GO:0008022		Acetylation; Alternative splicing; Coiled coil; Complete proteome; Direct protein sequencing; Phosphoprotein; Polymorphism; Reference proteome	Alternative sequence (7); Chain (1); Coiled coil (2); Compositional bias (8); Modified residue (22); Natural variant (11); Sequence caution (4); Sequence conflict (5)
I2BPL_HUMAN	Q9H1B7	I2BPL_HUMAN	reviewed	Interferon regulatory factor 2-binding protein-like (Enhanced at puberty protein 1)	IRF2BPL C14orf4 EAP1 KIAA1865 My039	Homo sapiens (Human)	796	extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; development of secondary female sexual characteristics [GO:0046543]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]	development of secondary female sexual characteristics [GO:0046543]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]	metal ion binding [GO:0046872]	extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0046543; GO:0005615; GO:0046872; GO:0000122; GO:0005654; GO:0005634; GO:0045944	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.	3D-structure; Coiled coil; Complete proteome; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Triplet repeat expansion; Zinc; Zinc-finger	Beta strand (4); Chain (1); Coiled coil (2); Compositional bias (5); Helix (2); Modified residue (7); Mutagenesis (1); Sequence caution (1); Zinc finger (1)
B3KSI3_HUMAN	B3KSI3	B3KSI3_HUMAN	unreviewed	Branched-chain-amino-acid aminotransferase (EC 2.6.1.42)	BCAT2	Homo sapiens (Human)	352	L-isoleucine transaminase activity [GO:0052656]; L-leucine transaminase activity [GO:0052654]; L-valine transaminase activity [GO:0052655]; branched-chain amino acid biosynthetic process [GO:0009082]	branched-chain amino acid biosynthetic process [GO:0009082]	L-isoleucine transaminase activity [GO:0052656]; L-leucine transaminase activity [GO:0052654]; L-valine transaminase activity [GO:0052655]		GO:0052656; GO:0052654; GO:0052655; GO:0009082		Amino-acid biosynthesis; Aminotransferase; Branched-chain amino acid biosynthesis; Complete proteome; Proteomics identification; Pyridoxal phosphate; Reference proteome; Transferase	Modified residue (1)
M0QZP4_HUMAN	M0QZP4	M0QZP4_HUMAN	unreviewed	Branched-chain-amino-acid aminotransferase (EC 2.6.1.42)	BCAT2	Homo sapiens (Human)	313	L-isoleucine transaminase activity [GO:0052656]; L-leucine transaminase activity [GO:0052654]; L-valine transaminase activity [GO:0052655]; branched-chain amino acid biosynthetic process [GO:0009082]	branched-chain amino acid biosynthetic process [GO:0009082]	L-isoleucine transaminase activity [GO:0052656]; L-leucine transaminase activity [GO:0052654]; L-valine transaminase activity [GO:0052655]		GO:0052656; GO:0052654; GO:0052655; GO:0009082		Amino-acid biosynthesis; Aminotransferase; Branched-chain amino acid biosynthesis; Complete proteome; Proteomics identification; Pyridoxal phosphate; Reference proteome; Transferase	Modified residue (1)
TNPO1_HUMAN	Q92973	TNPO1_HUMAN	reviewed	Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP)	TNPO1 KPNB2 MIP1 TRN	Homo sapiens (Human)	898	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; primary cilium [GO:0072372]; nuclear localization sequence binding [GO:0008139]; poly(A) RNA binding [GO:0044822]; gene expression [GO:0010467]; organelle organization [GO:0006996]; protein import into nucleus, translocation [GO:0000060]; viral process [GO:0016032]	gene expression [GO:0010467]; organelle organization [GO:0006996]; protein import into nucleus, translocation [GO:0000060]; viral process [GO:0016032]	nuclear localization sequence binding [GO:0008139]; poly(A) RNA binding [GO:0044822]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; primary cilium [GO:0072372]	GO:0005737; GO:0005829; GO:0070062; GO:0010467; GO:0008139; GO:0005634; GO:0006996; GO:0044822; GO:0072372; GO:0000060; GO:0016032	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Host-virus interaction; Nucleus; Polymorphism; Protein transport; Reference proteome; Repeat; Transport	Alternative sequence (2); Beta strand (9); Chain (1); Compositional bias (1); Domain (1); Erroneous initiation (2); Helix (67); Natural variant (1); Repeat (20); Sequence conflict (4); Turn (9)
PP2BB_HUMAN	P16298	PP2BB_HUMAN	reviewed	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit beta isoform)	PPP3CB CALNA2 CALNB CNA2	Homo sapiens (Human)	524	calcineurin complex [GO:0005955]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]; Z disc [GO:0030018]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; calmodulin-dependent protein phosphatase activity [GO:0033192]; drug binding [GO:0008144]; enzyme binding [GO:0019899]; protein dimerization activity [GO:0046983]; protein phosphatase 2B binding [GO:0030346]; protein serine/threonine phosphatase activity [GO:0004722]; axon extension [GO:0048675]; calcineurin-NFAT signaling cascade [GO:0033173]; calcium ion-dependent exocytosis [GO:0017156]; cellular response to drug [GO:0035690]; dephosphorylation [GO:0016311]; Fc-epsilon receptor signaling pathway [GO:0038095]; heart development [GO:0007507]; innate immune response [GO:0045087]; learning [GO:0007612]; locomotion involved in locomotory behavior [GO:0031987]; memory [GO:0007613]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of NFAT protein import into nucleus [GO:0051533]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]; protein dephosphorylation [GO:0006470]; protein phosphorylation [GO:0006468]; regulation of insulin secretion [GO:0050796]; regulation of synaptic plasticity [GO:0048167]; response to cytokine [GO:0034097]; signal transduction [GO:0007165]; social behavior [GO:0035176]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell activation [GO:0042110]; T cell differentiation [GO:0030217]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098]	axon extension [GO:0048675]; calcineurin-NFAT signaling cascade [GO:0033173]; calcium ion-dependent exocytosis [GO:0017156]; cellular response to drug [GO:0035690]; dephosphorylation [GO:0016311]; Fc-epsilon receptor signaling pathway [GO:0038095]; heart development [GO:0007507]; innate immune response [GO:0045087]; learning [GO:0007612]; locomotion involved in locomotory behavior [GO:0031987]; memory [GO:0007613]; negative regulation of T cell mediated cytotoxicity [GO:0001915]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of NFAT protein import into nucleus [GO:0051533]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; protein dephosphorylation [GO:0006470]; protein phosphorylation [GO:0006468]; regulation of insulin secretion [GO:0050796]; regulation of synaptic plasticity [GO:0048167]; response to cytokine [GO:0034097]; signal transduction [GO:0007165]; social behavior [GO:0035176]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell activation [GO:0042110]; T cell differentiation [GO:0030217]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098]	calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; calmodulin-dependent protein phosphatase activity [GO:0033192]; drug binding [GO:0008144]; enzyme binding [GO:0019899]; protein dimerization activity [GO:0046983]; protein phosphatase 2B binding [GO:0030346]; protein serine/threonine phosphatase activity [GO:0004722]	calcineurin complex [GO:0005955]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]; Z disc [GO:0030018]	GO:0038095; GO:0042110; GO:0030217; GO:0043029; GO:0042098; GO:0030315; GO:0030018; GO:0048675; GO:0005955; GO:0033173; GO:0005509; GO:0017156; GO:0005516; GO:0033192; GO:0035690; GO:0005829; GO:0016311; GO:0008144; GO:0019899; GO:0007507; GO:0045087; GO:0007612; GO:0031987; GO:0007613; GO:0001915; GO:0005654; GO:0005886; GO:0051533; GO:0035774; GO:0045944; GO:0045893; GO:0006470; GO:0046983; GO:0030346; GO:0006468; GO:0004722; GO:0050796; GO:0048167; GO:0034097; GO:0007165; GO:0035176; GO:0002223		Acetylation; Alternative splicing; Calmodulin-binding; Complete proteome; Hydrolase; Iron; Metal-binding; Protein phosphatase; Reference proteome; Zinc	Active site (1); Alternative sequence (4); Chain (1); Compositional bias (1); Initiator methionine (1); Metal binding (7); Modified residue (1); Region (5)
PRP31_HUMAN	Q8WWY3	PRP31_HUMAN	reviewed	U4/U6 small nuclear ribonucleoprotein Prp31 (Pre-mRNA-processing factor 31) (Serologically defined breast cancer antigen NY-BR-99) (U4/U6 snRNP 61 kDa protein) (Protein 61K) (hPrp31)	PRPF31 PRP31	Homo sapiens (Human)	499	Cajal body [GO:0015030]; MLL1 complex [GO:0071339]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; U2-type spliceosomal complex [GO:0005684]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U4atac snRNP [GO:0005690]; poly(A) RNA binding [GO:0044822]; ribonucleoprotein complex binding [GO:0043021]; snRNP binding [GO:0070990]; mRNA splicing, via spliceosome [GO:0000398]; spliceosomal tri-snRNP complex assembly [GO:0000244]	mRNA splicing, via spliceosome [GO:0000398]; spliceosomal tri-snRNP complex assembly [GO:0000244]	poly(A) RNA binding [GO:0044822]; ribonucleoprotein complex binding [GO:0043021]; snRNP binding [GO:0070990]	Cajal body [GO:0015030]; MLL1 complex [GO:0071339]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; U2-type spliceosomal complex [GO:0005684]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U4atac snRNP [GO:0005690]; U4 snRNP [GO:0005687]	GO:0015030; GO:0071339; GO:0005684; GO:0005687; GO:0046540; GO:0005690; GO:0000398; GO:0016607; GO:0005634; GO:0044822; GO:0043021; GO:0070990; GO:0000244	SUBCELLULAR LOCATION: Nucleus speckle. Nucleus, Cajal body. Note=Predominantly found in speckles and in Cajal bodies.	3D-structure; Acetylation; Alternative splicing; Coiled coil; Complete proteome; Disease mutation; Nucleus; Phosphoprotein; RNA-binding; Reference proteome; Retinitis pigmentosa; Ribonucleoprotein; Spliceosome; mRNA processing; mRNA splicing	Alternative sequence (5); Chain (1); Coiled coil (2); Compositional bias (2); Domain (1); Helix (15); Modified residue (5); Motif (1); Mutagenesis (2); Natural variant (3); Sequence conflict (3); Site (2); Turn (3)
ACPH_HUMAN	P13798	ACPH_HUMAN	reviewed	Acylamino-acid-releasing enzyme (AARE) (EC 3.4.19.1) (Acyl-peptide hydrolase) (APH) (Acylaminoacyl-peptidase) (Oxidized protein hydrolase) (OPH)	APEH D3F15S2 D3S48E DNF15S2	Homo sapiens (Human)	732	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nuclear membrane [GO:0031965]; omega peptidase activity [GO:0008242]; poly(A) RNA binding [GO:0044822]; serine-type endopeptidase activity [GO:0004252]; beta-amyloid metabolic process [GO:0050435]; proteolysis [GO:0006508]	beta-amyloid metabolic process [GO:0050435]; proteolysis [GO:0006508]	omega peptidase activity [GO:0008242]; poly(A) RNA binding [GO:0044822]; serine-type endopeptidase activity [GO:0004252]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nuclear membrane [GO:0031965]	GO:0050435; GO:0005737; GO:0070062; GO:0031965; GO:0008242; GO:0044822; GO:0006508; GO:0004252	SUBCELLULAR LOCATION: Cytoplasm.	Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Phosphoprotein; Polymorphism; Reference proteome	Active site (3); Chain (1); Frameshift (1); Mass spectrometry (1); Modified residue (3); Natural variant (1); Sequence conflict (5)
C9JIF9_HUMAN	C9JIF9	C9JIF9_HUMAN	unreviewed	Acylamino-acid-releasing enzyme	APEH	Homo sapiens (Human)	737	cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; serine-type endopeptidase activity [GO:0004252]		serine-type endopeptidase activity [GO:0004252]	cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]	GO:0005737; GO:0031965; GO:0004252		Complete proteome; Proteomics identification; Reference proteome	
CUTA_HUMAN	O60888	CUTA_HUMAN	reviewed	Protein CutA (Acetylcholinesterase-associated protein) (Brain acetylcholinesterase putative membrane anchor)	CUTA ACHAP C6orf82	Homo sapiens (Human)	179	extracellular exosome [GO:0070062]; membrane [GO:0016020]; enzyme binding [GO:0019899]; protein localization [GO:0008104]; response to metal ion [GO:0010038]	protein localization [GO:0008104]; response to metal ion [GO:0010038]	enzyme binding [GO:0019899]	extracellular exosome [GO:0070062]; membrane [GO:0016020]	GO:0019899; GO:0070062; GO:0016020; GO:0008104; GO:0010038		3D-structure; Alternative splicing; Complete proteome; Direct protein sequencing; Glycoprotein; Reference proteome; Signal	Alternative sequence (2); Beta strand (5); Chain (1); Compositional bias (1); Erroneous initiation (1); Helix (4); Region (1); Signal peptide (1)
AMPL_HUMAN	P28838	AMPL_HUMAN	reviewed	Cytosol aminopeptidase (EC 3.4.11.1) (Leucine aminopeptidase 3) (LAP-3) (Leucyl aminopeptidase) (Peptidase S) (Proline aminopeptidase) (EC 3.4.11.5) (Prolyl aminopeptidase)	LAP3 LAPEP PEPS	Homo sapiens (Human)	519	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; trans-Golgi network [GO:0005802]; aminopeptidase activity [GO:0004177]; manganese ion binding [GO:0030145]; metalloexopeptidase activity [GO:0008235]; proteolysis [GO:0006508]	proteolysis [GO:0006508]	aminopeptidase activity [GO:0004177]; manganese ion binding [GO:0030145]; metalloexopeptidase activity [GO:0008235]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; trans-Golgi network [GO:0005802]	GO:0004177; GO:0005737; GO:0070062; GO:0005925; GO:0030145; GO:0008235; GO:0005739; GO:0005654; GO:0005634; GO:0006508; GO:0005802	SUBCELLULAR LOCATION: Cytoplasm.	Acetylation; Alternative initiation; Aminopeptidase; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Magnesium; Manganese; Metal-binding; Phosphoprotein; Protease; Reference proteome; Zinc	Active site (2); Alternative sequence (1); Chain (1); Metal binding (7); Modified residue (13); Sequence conflict (3)
CDC37_HUMAN	Q16543	CDC37_HUMAN	reviewed	Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]	CDC37 CDC37A	Homo sapiens (Human)	378	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; protein complex [GO:0043234]; ruffle membrane [GO:0032587]; chaperone binding [GO:0051087]; heat shock protein binding [GO:0031072]; kinase binding [GO:0019900]; unfolded protein binding [GO:0051082]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; protein targeting [GO:0006605]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of interferon-gamma-mediated signaling pathway [GO:0060334]; regulation of type I interferon-mediated signaling pathway [GO:0060338]	protein folding [GO:0006457]; protein stabilization [GO:0050821]; protein targeting [GO:0006605]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of interferon-gamma-mediated signaling pathway [GO:0060334]; regulation of type I interferon-mediated signaling pathway [GO:0060338]	chaperone binding [GO:0051087]; heat shock protein binding [GO:0031072]; kinase binding [GO:0019900]; unfolded protein binding [GO:0051082]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; protein complex [GO:0043234]; ruffle membrane [GO:0032587]	GO:0051087; GO:0005737; GO:0005829; GO:0070062; GO:0031072; GO:0019900; GO:0043234; GO:0006457; GO:0050821; GO:0006605; GO:0000079; GO:0060334; GO:0060338; GO:0032587; GO:0051082	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9482106}.	3D-structure; Acetylation; Chaperone; Complete proteome; Cytoplasm; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation	Beta strand (1); Chain (2); Helix (10); Initiator methionine (1); Modified residue (6); Natural variant (1)
P20D2_HUMAN	Q8IYS1	P20D2_HUMAN	reviewed	Peptidase M20 domain-containing protein 2 (Aminoacylase-1-like protein 2)	PM20D2 ACY1L2	Homo sapiens (Human)	436	extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; hydrolase activity [GO:0016787]		hydrolase activity [GO:0016787]	extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]	GO:0070062; GO:0016787; GO:0005654		Complete proteome; Polymorphism; Reference proteome	Chain (1); Natural variant (1); Sequence conflict (3)
PROSC_HUMAN	O94903	PROSC_HUMAN	reviewed	Proline synthase co-transcribed bacterial homolog protein	PROSC	Homo sapiens (Human)	275	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intracellular [GO:0005622]; mitochondrion [GO:0005739]; pyridoxal phosphate binding [GO:0030170]		pyridoxal phosphate binding [GO:0030170]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intracellular [GO:0005622]; mitochondrion [GO:0005739]	GO:0005737; GO:0070062; GO:0005622; GO:0005739; GO:0030170		Complete proteome; Phosphoprotein; Polymorphism; Pyridoxal phosphate; Reference proteome	Chain (1); Modified residue (5); Natural variant (1)
K0907_HUMAN	Q7Z7F0	K0907_HUMAN	reviewed	UPF0469 protein KIAA0907	KIAA0907 BLOM7	Homo sapiens (Human)	614	RNA binding [GO:0003723]		RNA binding [GO:0003723]		GO:0003723		3D-structure; Alternative splicing; Complete proteome; Phosphoprotein; Reference proteome	Alternative sequence (6); Beta strand (4); Chain (1); Compositional bias (1); Erroneous initiation (1); Helix (4); Modified residue (2); Turn (2)
CPSF3_HUMAN	Q9UKF6	CPSF3_HUMAN	reviewed	Cleavage and polyadenylation specificity factor subunit 3 (EC 3.1.27.-) (Cleavage and polyadenylation specificity factor 73 kDa subunit) (CPSF 73 kDa subunit) (mRNA 3'-end-processing endonuclease CPSF-73)	CPSF3 CPSF73	Homo sapiens (Human)	684	mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:0030529]; 5'-3' exonuclease activity [GO:0008409]; endoribonuclease activity [GO:0004521]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; gene expression [GO:0010467]; histone mRNA 3'-end processing [GO:0006398]; mRNA 3'-end processing [GO:0031124]; mRNA cleavage [GO:0006379]; mRNA export from nucleus [GO:0006406]; mRNA polyadenylation [GO:0006378]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; termination of RNA polymerase II transcription [GO:0006369]; transcription from RNA polymerase II promoter [GO:0006366]	gene expression [GO:0010467]; histone mRNA 3'-end processing [GO:0006398]; mRNA 3'-end processing [GO:0031124]; mRNA cleavage [GO:0006379]; mRNA export from nucleus [GO:0006406]; mRNA polyadenylation [GO:0006378]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; termination of RNA polymerase II transcription [GO:0006369]; transcription from RNA polymerase II promoter [GO:0006366]	5'-3' exonuclease activity [GO:0008409]; endoribonuclease activity [GO:0004521]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]	mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:0030529]	GO:0008409; GO:0003723; GO:0008380; GO:0004521; GO:0010467; GO:0006398; GO:0031124; GO:0006379; GO:0005847; GO:0006406; GO:0006378; GO:0000398; GO:0046872; GO:0005654; GO:0030529; GO:0006369; GO:0006366	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15037765}.	3D-structure; Acetylation; Complete proteome; Endonuclease; Hydrolase; Isopeptide bond; Metal-binding; Nuclease; Nucleus; Phosphoprotein; Polymorphism; RNA-binding; Reference proteome; Ribonucleoprotein; Ubl conjugation; Zinc; mRNA processing	Active site (1); Beta strand (24); Chain (1); Cross-link (3); Helix (17); Initiator methionine (1); Metal binding (8); Modified residue (2); Mutagenesis (9); Natural variant (2); Turn (2)
LIMK2_HUMAN	P53671	LIMK2_HUMAN	reviewed	LIM domain kinase 2 (LIMK-2) (EC 2.7.11.1)	LIMK2	Homo sapiens (Human)	638	cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; zinc ion binding [GO:0008270]; phosphorylation [GO:0016310]; spermatogenesis [GO:0007283]	phosphorylation [GO:0016310]; spermatogenesis [GO:0007283]	ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; zinc ion binding [GO:0008270]	cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005524; GO:0005801; GO:0005737; GO:0005634; GO:0016310; GO:0004674; GO:0007283; GO:0008270	SUBCELLULAR LOCATION: Isoform LIMK2a: Cytoplasm. Nucleus. Note=Isoform LIMK2a is distributed in the cytoplasm and the nucleus.; SUBCELLULAR LOCATION: Isoform LIMK2b: Cytoplasm. Nucleus. Note=Isoform LIMK2b occurs mainly in the cytoplasm and is scarcely translocated to the nucleus.	3D-structure; ATP-binding; Alternative splicing; Complete proteome; Cytoplasm; Kinase; LIM domain; Metal-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc	Active site (1); Alternative sequence (2); Beta strand (13); Binding site (1); Chain (1); Domain (4); Erroneous gene model prediction (1); Helix (12); Modified residue (4); Mutagenesis (2); Natural variant (6); Nucleotide binding (1); Turn (6)
D6RCM5_HUMAN	D6RCM5	D6RCM5_HUMAN	unreviewed	RWD domain-containing protein 4	RWDD4	Homo sapiens (Human)	44							Complete proteome; Proteomics identification; Reference proteome	
D6RDH6_HUMAN	D6RDH6	D6RDH6_HUMAN	unreviewed	RWD domain-containing protein 4	RWDD4	Homo sapiens (Human)	53							Complete proteome; Proteomics identification; Reference proteome	
SC24B_HUMAN	O95487	SC24B_HUMAN	reviewed	Protein transport protein Sec24B (SEC24-related protein B)	SEC24B	Homo sapiens (Human)	1268	COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; transporter activity [GO:0005215]; zinc ion binding [GO:0008270]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; aorta morphogenesis [GO:0035909]; auditory receptor cell stereocilium organization [GO:0060088]; cellular protein metabolic process [GO:0044267]; cochlear nucleus development [GO:0021747]; COPII vesicle coating [GO:0048208]; coronary artery morphogenesis [GO:0060982]; ER to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; lung lobe morphogenesis [GO:0060463]; membrane organization [GO:0061024]; neural tube closure [GO:0001843]; outflow tract morphogenesis [GO:0003151]; post-translational protein modification [GO:0043687]; protein N-linked glycosylation via asparagine [GO:0018279]; pulmonary artery morphogenesis [GO:0061156]; regulation of cargo loading into COPII-coated vesicle [GO:1901301]; regulation of establishment of planar polarity involved in neural tube closure [GO:0090178]; small molecule metabolic process [GO:0044281]; vesicle-mediated transport [GO:0016192]	antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; aorta morphogenesis [GO:0035909]; auditory receptor cell stereocilium organization [GO:0060088]; cellular protein metabolic process [GO:0044267]; cochlear nucleus development [GO:0021747]; COPII vesicle coating [GO:0048208]; coronary artery morphogenesis [GO:0060982]; ER to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; lung lobe morphogenesis [GO:0060463]; membrane organization [GO:0061024]; neural tube closure [GO:0001843]; outflow tract morphogenesis [GO:0003151]; post-translational protein modification [GO:0043687]; protein N-linked glycosylation via asparagine [GO:0018279]; pulmonary artery morphogenesis [GO:0061156]; regulation of cargo loading into COPII-coated vesicle [GO:1901301]; regulation of establishment of planar polarity involved in neural tube closure [GO:0090178]; small molecule metabolic process [GO:0044281]; vesicle-mediated transport [GO:0016192]	transporter activity [GO:0005215]; zinc ion binding [GO:0008270]	COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]	GO:0030127; GO:0048208; GO:0012507; GO:0006888; GO:0000139; GO:0019886; GO:0002474; GO:0035909; GO:0060088; GO:0044267; GO:0021747; GO:0060982; GO:0005829; GO:0005789; GO:0006886; GO:0060463; GO:0016020; GO:0061024; GO:0001843; GO:0003151; GO:0048471; GO:0043687; GO:0018279; GO:0061156; GO:1901301; GO:0090178; GO:0044281; GO:0005215; GO:0016192; GO:0008270	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum membrane {ECO:0000305}. Golgi apparatus membrane {ECO:0000250}.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; ER-Golgi transport; Endoplasmic reticulum; Golgi apparatus; Membrane; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport	Alternative sequence (3); Beta strand (30); Chain (1); Compositional bias (1); Frameshift (1); Helix (31); Initiator methionine (1); Modified residue (2); Natural variant (1); Region (1); Sequence conflict (1); Turn (10)
SORT_HUMAN	Q99523	SORT_HUMAN	reviewed	Sortilin (100 kDa NT receptor) (Glycoprotein 95) (Gp95) (Neurotensin receptor 3) (NT3) (NTR3)	SORT1	Homo sapiens (Human)	831	cell surface [GO:0009986]; clathrin-coated vesicle [GO:0030136]; coated pit [GO:0005905]; cytoplasmic membrane-bounded vesicle [GO:0016023]; early endosome [GO:0005769]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; integral component of membrane [GO:0016021]; lysosomal membrane [GO:0005765]; nuclear membrane [GO:0031965]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network transport vesicle [GO:0030140]; enzyme binding [GO:0019899]; nerve growth factor binding [GO:0048406]; nerve growth factor receptor activity [GO:0010465]; neurotensin receptor activity, non-G-protein coupled [GO:0030379]; endocytosis [GO:0006897]; endosome to lysosome transport [GO:0008333]; endosome transport via multivesicular body sorting pathway [GO:0032509]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; G-protein coupled receptor signaling pathway [GO:0007186]; glucose import [GO:0046323]; Golgi to endosome transport [GO:0006895]; multicellular organismal development [GO:0007275]; myotube differentiation [GO:0014902]; negative regulation of lipoprotein lipase activity [GO:0051005]; nerve growth factor signaling pathway [GO:0038180]; neuropeptide signaling pathway [GO:0007218]; neurotrophin TRK receptor signaling pathway [GO:0048011]; ossification [GO:0001503]; plasma membrane to endosome transport [GO:0048227]; regulation of gene expression [GO:0010468]; response to insulin [GO:0032868]; vesicle organization [GO:0016050]	endocytosis [GO:0006897]; endosome to lysosome transport [GO:0008333]; endosome transport via multivesicular body sorting pathway [GO:0032509]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; glucose import [GO:0046323]; Golgi to endosome transport [GO:0006895]; G-protein coupled receptor signaling pathway [GO:0007186]; multicellular organismal development [GO:0007275]; myotube differentiation [GO:0014902]; negative regulation of lipoprotein lipase activity [GO:0051005]; nerve growth factor signaling pathway [GO:0038180]; neuropeptide signaling pathway [GO:0007218]; neurotrophin TRK receptor signaling pathway [GO:0048011]; ossification [GO:0001503]; plasma membrane to endosome transport [GO:0048227]; regulation of gene expression [GO:0010468]; response to insulin [GO:0032868]; vesicle organization [GO:0016050]	enzyme binding [GO:0019899]; nerve growth factor binding [GO:0048406]; nerve growth factor receptor activity [GO:0010465]; neurotensin receptor activity, non-G-protein coupled [GO:0030379]	cell surface [GO:0009986]; clathrin-coated vesicle [GO:0030136]; coated pit [GO:0005905]; cytoplasmic membrane-bounded vesicle [GO:0016023]; early endosome [GO:0005769]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; integral component of membrane [GO:0016021]; lysosomal membrane [GO:0005765]; nuclear membrane [GO:0031965]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; trans-Golgi network transport vesicle [GO:0030140]	GO:0007186; GO:0005794; GO:0032580; GO:0006895; GO:0009986; GO:0030136; GO:0005905; GO:0016023; GO:0005769; GO:0006897; GO:0005789; GO:0010008; GO:0008333; GO:0032509; GO:0019899; GO:0008625; GO:0046323; GO:0016021; GO:0005765; GO:0007275; GO:0014902; GO:0051005; GO:0048406; GO:0010465; GO:0038180; GO:0007218; GO:0030379; GO:0048011; GO:0031965; GO:0001503; GO:0048471; GO:0005886; GO:0048227; GO:0010468; GO:0032868; GO:0030140; GO:0016050	SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Endosome membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Golgi apparatus, Golgi stack membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Nucleus membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell membrane; Single-pass type I membrane protein; Extracellular side. Lysosome membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Localized to membranes of the endoplasmic reticulum, endosomes, Golgi stack, lysosomes and nucleus. A small fraction of the protein is also localized to the plasma membrane. May also be found in SLC2A4/GLUT4 storage vesicles (GSVs) in adipocytes. Localization to the plasma membrane in adipocytes may be enhanced by insulin.	3D-structure; Alternative splicing; Cell membrane; Cleavage on pair of basic residues; Complete proteome; Developmental protein; Differentiation; Direct protein sequencing; Disulfide bond; Endocytosis; Endoplasmic reticulum; Endosome; Glycoprotein; Golgi apparatus; Lysosome; Membrane; Nucleus; Osteogenesis; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix; Transport	Alternative sequence (2); Beta strand (51); Chain (1); Disulfide bond (8); Glycosylation (7); Helix (13); Modified residue (2); Motif (1); Mutagenesis (9); Natural variant (1); Propeptide (1); Region (3); Repeat (9); Sequence conflict (1); Signal peptide (1); Topological domain (2); Transmembrane (1); Turn (3)
IN35_HUMAN	P80217	IN35_HUMAN	reviewed	Interferon-induced 35 kDa protein (IFP 35) (Ifi-35)	IFI35 IFP35	Homo sapiens (Human)	286	cytosol [GO:0005829]; nucleus [GO:0005634]; cytokine-mediated signaling pathway [GO:0019221]; type I interferon signaling pathway [GO:0060337]	cytokine-mediated signaling pathway [GO:0019221]; type I interferon signaling pathway [GO:0060337]		cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0019221; GO:0005829; GO:0005634; GO:0060337	SUBCELLULAR LOCATION: Nucleus. Note=Nuclear following IFN treatment.	Alternative splicing; Complete proteome; Direct protein sequencing; Nucleus; Polymorphism; Reference proteome	Alternative sequence (1); Chain (1); Initiator methionine (1); Natural variant (2); Region (1); Sequence caution (1); Sequence conflict (1)
YTHD2_HUMAN	Q9Y5A9	YTHD2_HUMAN	reviewed	YTH domain-containing family protein 2 (CLL-associated antigen KW-14) (High-glucose-regulated protein 8) (Renal carcinoma antigen NY-REN-2)	YTHDF2 HGRG8	Homo sapiens (Human)	579	cytoplasmic mRNA processing body [GO:0000932]; N6-methyladenosine-containing RNA binding [GO:1990247]; poly(A) RNA binding [GO:0044822]; humoral immune response [GO:0006959]; regulation of mRNA stability [GO:0043488]	humoral immune response [GO:0006959]; regulation of mRNA stability [GO:0043488]	N6-methyladenosine-containing RNA binding [GO:1990247]; poly(A) RNA binding [GO:0044822]	cytoplasmic mRNA processing body [GO:0000932]	GO:1990247; GO:0000932; GO:0006959; GO:0044822; GO:0043488	SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000269|PubMed:24284625}.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Phosphoprotein; Polymorphism; RNA-binding; Reference proteome	Alternative sequence (1); Beta strand (7); Binding site (4); Chain (1); Domain (1); Frameshift (2); Helix (5); Initiator methionine (1); Modified residue (4); Mutagenesis (7); Natural variant (2); Region (4); Sequence caution (1); Turn (2)
R4GN55_HUMAN	R4GN55	R4GN55_HUMAN		Deleted.											
GSTM3_HUMAN	P21266	GSTM3_HUMAN	reviewed	Glutathione S-transferase Mu 3 (EC 2.5.1.18) (GST class-mu 3) (GSTM3-3) (hGSTM3-3)	GSTM3 GST5	Homo sapiens (Human)	225	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; sperm fibrous sheath [GO:0035686]; enzyme binding [GO:0019899]; glutathione binding [GO:0043295]; glutathione transferase activity [GO:0004364]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; cellular detoxification of nitrogen compound [GO:0070458]; establishment of blood-nerve barrier [GO:0008065]; glutathione derivative biosynthetic process [GO:1901687]; glutathione metabolic process [GO:0006749]; nitrobenzene metabolic process [GO:0018916]; response to estrogen [GO:0043627]; small molecule metabolic process [GO:0044281]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805]	cellular detoxification of nitrogen compound [GO:0070458]; establishment of blood-nerve barrier [GO:0008065]; glutathione derivative biosynthetic process [GO:1901687]; glutathione metabolic process [GO:0006749]; nitrobenzene metabolic process [GO:0018916]; response to estrogen [GO:0043627]; small molecule metabolic process [GO:0044281]; xenobiotic catabolic process [GO:0042178]; xenobiotic metabolic process [GO:0006805]	enzyme binding [GO:0019899]; glutathione binding [GO:0043295]; glutathione transferase activity [GO:0004364]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; sperm fibrous sheath [GO:0035686]	GO:0070458; GO:0005737; GO:0005829; GO:0019899; GO:0008065; GO:0070062; GO:0043295; GO:1901687; GO:0006749; GO:0004364; GO:0042802; GO:0018916; GO:0005634; GO:0042803; GO:0043627; GO:0044281; GO:0035686; GO:0042178; GO:0006805	SUBCELLULAR LOCATION: Cytoplasm.	3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Polymorphism; Reference proteome; Transferase	Beta strand (8); Binding site (1); Chain (1); Domain (2); Helix (11); Mutagenesis (4); Natural variant (1); Region (4); Sequence conflict (1)
STABP_HUMAN	O95630	STABP_HUMAN	reviewed	STAM-binding protein (EC 3.4.19.-) (Associated molecule with the SH3 domain of STAM) (Endosome-associated ubiquitin isopeptidase)	STAMBP AMSH	Homo sapiens (Human)	424	cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237]; protein domain specific binding [GO:0019904]; ubiquitin-specific protease activity [GO:0004843]; JAK-STAT cascade [GO:0007259]; mitotic cytokinesis [GO:0000281]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of phosphatidylinositol 3-kinase signaling [GO:0014067]; negative regulation of Ras protein signal transduction [GO:0046580]; positive regulation of cell proliferation [GO:0008284]; protein deubiquitination [GO:0016579]	JAK-STAT cascade [GO:0007259]; mitotic cytokinesis [GO:0000281]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of phosphatidylinositol 3-kinase signaling [GO:0014067]; negative regulation of Ras protein signal transduction [GO:0046580]; positive regulation of cell proliferation [GO:0008284]; protein deubiquitination [GO:0016579]	metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237]; protein domain specific binding [GO:0019904]; ubiquitin-specific protease activity [GO:0004843]	cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0007259; GO:0032154; GO:0005737; GO:0005769; GO:0070062; GO:0046872; GO:0008237; GO:0000281; GO:0046580; GO:0043524; GO:0014067; GO:0005654; GO:0005634; GO:0005886; GO:0008284; GO:0016579; GO:0019904; GO:0004843	SUBCELLULAR LOCATION: Nucleus. Membrane; Peripheral membrane protein. Cytoplasm. Early endosome.	3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Disease mutation; Endosome; Hydrolase; Membrane; Metal-binding; Metalloprotease; Nucleus; Phosphoprotein; Protease; Reference proteome; Ubl conjugation; Ubl conjugation pathway; Zinc	Alternative sequence (1); Beta strand (12); Chain (1); Compositional bias (1); Domain (1); Helix (10); Metal binding (7); Modified residue (5); Motif (1); Mutagenesis (1); Natural variant (6); Region (2); Site (1); Turn (2)
ACPM_HUMAN	O14561	ACPM_HUMAN	reviewed	Acyl carrier protein, mitochondrial (ACP) (CI-SDAP) (NADH-ubiquinone oxidoreductase 9.6 kDa subunit)	NDUFAB1	Homo sapiens (Human)	156	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex I [GO:0005747]; ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process [GO:0000036]; calcium ion binding [GO:0005509]; fatty acid binding [GO:0005504]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; cellular metabolic process [GO:0044237]; fatty acid biosynthetic process [GO:0006633]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; protein lipoylation [GO:0009249]; respiratory electron transport chain [GO:0022904]; small molecule metabolic process [GO:0044281]	cellular metabolic process [GO:0044237]; fatty acid biosynthetic process [GO:0006633]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; protein lipoylation [GO:0009249]; respiratory electron transport chain [GO:0022904]; small molecule metabolic process [GO:0044281]	ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process [GO:0000036]; calcium ion binding [GO:0005509]; fatty acid binding [GO:0005504]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]	mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial membrane [GO:0031966]; mitochondrial respiratory chain complex I [GO:0005747]	GO:0000036; GO:0008137; GO:0005509; GO:0044237; GO:0005504; GO:0006633; GO:0006120; GO:0005743; GO:0005759; GO:0031966; GO:0005747; GO:0009249; GO:0022904; GO:0044281	SUBCELLULAR LOCATION: Mitochondrion.	3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Electron transport; Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism; Mitochondrion; Phosphopantetheine; Phosphoprotein; Reference proteome; Respiratory chain; Transit peptide; Transport	Chain (1); Erroneous initiation (1); Helix (5); Modified residue (2); Sequence conflict (1); Transit peptide (1); Turn (1)
I3L3U9_HUMAN	I3L3U9	I3L3U9_HUMAN	unreviewed	Ribosomal L1 domain-containing protein 1 (Fragment)	RSL1D1	Homo sapiens (Human)	296	RNA binding [GO:0003723]		RNA binding [GO:0003723]		GO:0003723		Complete proteome; Proteomics identification; Reference proteome	Non-terminal residue (1)
PP1A_HUMAN	P62136	PP1A_HUMAN	reviewed	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)	PPP1CA PPP1A	Homo sapiens (Human)	330	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glycogen granule [GO:0042587]; MLL5-L complex [GO:0070688]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; protein phosphatase type 1 complex [GO:0000164]; PTW/PP1 phosphatase complex [GO:0072357]; metal ion binding [GO:0046872]; phosphatase activity [GO:0016791]; protein serine/threonine phosphatase activity [GO:0004722]; ribonucleoprotein complex binding [GO:0043021]; branching morphogenesis of an epithelial tube [GO:0048754]; cell cycle [GO:0007049]; cell division [GO:0051301]; circadian regulation of gene expression [GO:0032922]; dephosphorylation [GO:0016311]; entrainment of circadian clock by photoperiod [GO:0043153]; glycogen metabolic process [GO:0005977]; lung development [GO:0030324]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; protein dephosphorylation [GO:0006470]; regulation of circadian rhythm [GO:0042752]; regulation of glycogen biosynthetic process [GO:0005979]; regulation of glycogen catabolic process [GO:0005981]; regulation of translational initiation by eIF2 alpha dephosphorylation [GO:0036496]; small molecule metabolic process [GO:0044281]; transforming growth factor beta receptor signaling pathway [GO:0007179]; triglyceride catabolic process [GO:0019433]	branching morphogenesis of an epithelial tube [GO:0048754]; cell cycle [GO:0007049]; cell division [GO:0051301]; circadian regulation of gene expression [GO:0032922]; dephosphorylation [GO:0016311]; entrainment of circadian clock by photoperiod [GO:0043153]; glycogen metabolic process [GO:0005977]; lung development [GO:0030324]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; protein dephosphorylation [GO:0006470]; regulation of circadian rhythm [GO:0042752]; regulation of glycogen biosynthetic process [GO:0005979]; regulation of glycogen catabolic process [GO:0005981]; regulation of translational initiation by eIF2 alpha dephosphorylation [GO:0036496]; small molecule metabolic process [GO:0044281]; transforming growth factor beta receptor signaling pathway [GO:0007179]; triglyceride catabolic process [GO:0019433]	metal ion binding [GO:0046872]; phosphatase activity [GO:0016791]; protein serine/threonine phosphatase activity [GO:0004722]; ribonucleoprotein complex binding [GO:0043021]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; glycogen granule [GO:0042587]; MLL5-L complex [GO:0070688]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; protein phosphatase type 1 complex [GO:0000164]; PTW/PP1 phosphatase complex [GO:0072357]	GO:0070688; GO:0072357; GO:0048754; GO:0007049; GO:0051301; GO:0032922; GO:0005737; GO:0005829; GO:0043197; GO:0016311; GO:0043153; GO:0070062; GO:0042587; GO:0005977; GO:0030324; GO:0046872; GO:0030512; GO:0005730; GO:0005654; GO:0005634; GO:0043204; GO:0016791; GO:0005886; GO:2001241; GO:0006470; GO:0000164; GO:0004722; GO:0042752; GO:0005979; GO:0005981; GO:0036496; GO:0043021; GO:0044281; GO:0007179; GO:0019433	SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting this protein to the nucleolus. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles.	3D-structure; Acetylation; Alternative splicing; Carbohydrate metabolism; Cell cycle; Cell division; Complete proteome; Cytoplasm; Direct protein sequencing; Glycogen metabolism; Hydrolase; Manganese; Metal-binding; Nucleus; Phosphoprotein; Protein phosphatase; Reference proteome	Active site (1); Alternative sequence (2); Beta strand (15); Chain (1); Helix (11); Initiator methionine (1); Metal binding (11); Modified residue (4); Turn (4)
TRA2B_HUMAN	P62995	TRA2B_HUMAN	reviewed	Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B)	TRA2B SFRS10	Homo sapiens (Human)	288	nucleus [GO:0005634]; mRNA binding [GO:0003729]; nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; response to reactive oxygen species [GO:0000302]; RNA splicing, via transesterification reactions [GO:0000375]	mRNA splicing, via spliceosome [GO:0000398]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; response to reactive oxygen species [GO:0000302]; RNA splicing, via transesterification reactions [GO:0000375]	mRNA binding [GO:0003729]; nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]	nucleus [GO:0005634]	GO:0000375; GO:0003729; GO:0000398; GO:0000166; GO:0005634; GO:0044822; GO:0048026; GO:0000381; GO:0000302	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9212162, ECO:0000269|PubMed:9546399}.	3D-structure; Acetylation; Activator; Alternative splicing; Complete proteome; Direct protein sequencing; Methylation; Nucleus; Phosphoprotein; RNA-binding; Reference proteome; Repressor; mRNA processing; mRNA splicing	Alternative sequence (3); Beta strand (6); Chain (1); Compositional bias (2); Domain (1); Helix (3); Initiator methionine (1); Modified residue (12); Region (1)
SNX12_HUMAN	Q9UMY4	SNX12_HUMAN	reviewed	Sorting nexin-12	SNX12	Homo sapiens (Human)	172	early endosome [GO:0005769]; extracellular exosome [GO:0070062]; extrinsic component of membrane [GO:0019898]; enzyme binding [GO:0019899]; phosphatidylinositol binding [GO:0035091]; endocytosis [GO:0006897]; negative regulation of early endosome to late endosome transport [GO:2000642]; negative regulation of gene expression [GO:0010629]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein processing [GO:0010955]; negative regulation of protein transport [GO:0051224]; protein transport [GO:0015031]; regulation of endocytosis [GO:0030100]; vesicle organization [GO:0016050]	endocytosis [GO:0006897]; negative regulation of early endosome to late endosome transport [GO:2000642]; negative regulation of gene expression [GO:0010629]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein processing [GO:0010955]; negative regulation of protein transport [GO:0051224]; protein transport [GO:0015031]; regulation of endocytosis [GO:0030100]; vesicle organization [GO:0016050]	enzyme binding [GO:0019899]; phosphatidylinositol binding [GO:0035091]	early endosome [GO:0005769]; extracellular exosome [GO:0070062]; extrinsic component of membrane [GO:0019898]	GO:0005769; GO:0006897; GO:0019899; GO:0070062; GO:0019898; GO:2000642; GO:0010629; GO:0042177; GO:0010955; GO:0051224; GO:0035091; GO:0015031; GO:0030100; GO:0016050	SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Lipid-binding; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transport	Alternative sequence (2); Beta strand (5); Binding site (4); Chain (1); Domain (1); Helix (4); Initiator methionine (1); Modified residue (3); Sequence conflict (1)
TBCE_HUMAN	Q15813	TBCE_HUMAN	reviewed	Tubulin-specific chaperone E (Tubulin-folding cofactor E)	TBCE	Homo sapiens (Human)	527	cytoplasm [GO:0005737]; microtubule [GO:0005874]; chaperone binding [GO:0051087]; 'de novo' posttranslational protein folding [GO:0051084]; adult locomotory behavior [GO:0008344]; cellular protein metabolic process [GO:0044267]; developmental growth [GO:0048589]; microtubule cytoskeleton organization [GO:0000226]; muscle atrophy [GO:0014889]; peripheral nervous system neuron axonogenesis [GO:0048936]; post-chaperonin tubulin folding pathway [GO:0007023]; post-embryonic development [GO:0009791]; protein folding [GO:0006457]	'de novo' posttranslational protein folding [GO:0051084]; adult locomotory behavior [GO:0008344]; cellular protein metabolic process [GO:0044267]; developmental growth [GO:0048589]; microtubule cytoskeleton organization [GO:0000226]; muscle atrophy [GO:0014889]; peripheral nervous system neuron axonogenesis [GO:0048936]; post-chaperonin tubulin folding pathway [GO:0007023]; post-embryonic development [GO:0009791]; protein folding [GO:0006457]	chaperone binding [GO:0051087]	cytoplasm [GO:0005737]; microtubule [GO:0005874]	GO:0051084; GO:0008344; GO:0044267; GO:0051087; GO:0005737; GO:0048589; GO:0005874; GO:0000226; GO:0014889; GO:0048936; GO:0007023; GO:0009791; GO:0006457	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.	3D-structure; Acetylation; Alternative splicing; Chaperone; Complete proteome; Cytoplasm; Cytoskeleton; Disease mutation; Dwarfism; Leucine-rich repeat; Mental retardation; Phosphoprotein; Polymorphism; Reference proteome; Repeat	Alternative sequence (1); Beta strand (4); Chain (1); Domain (2); Helix (4); Initiator methionine (1); Modified residue (3); Natural variant (4); Repeat (7); Sequence conflict (1); Turn (1)
Q5H907_HUMAN	Q5H907	Q5H907_HUMAN	unreviewed	Melanoma antigen family D, 2, isoform CRA_d (Melanoma-associated antigen D2)	MAGED2 hCG_18665	Homo sapiens (Human)	521							Complete proteome; Proteomics identification; Reference proteome	
TXND5_HUMAN	Q8NBS9	TXND5_HUMAN	reviewed	Thioredoxin domain-containing protein 5 (Endoplasmic reticulum resident protein 46) (ER protein 46) (ERp46) (Thioredoxin-like protein p46)	TXNDC5 TLP46 UNQ364/PRO700	Homo sapiens (Human)	432	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; lysosomal lumen [GO:0043202]; protein disulfide isomerase activity [GO:0003756]; apoptotic cell clearance [GO:0043277]; cell redox homeostasis [GO:0045454]; membrane organization [GO:0061024]; negative regulation of apoptotic process [GO:0043066]; post-Golgi vesicle-mediated transport [GO:0006892]; protein folding [GO:0006457]; response to endoplasmic reticulum stress [GO:0034976]	apoptotic cell clearance [GO:0043277]; cell redox homeostasis [GO:0045454]; membrane organization [GO:0061024]; negative regulation of apoptotic process [GO:0043066]; post-Golgi vesicle-mediated transport [GO:0006892]; protein folding [GO:0006457]; response to endoplasmic reticulum stress [GO:0034976]	protein disulfide isomerase activity [GO:0003756]	endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; lysosomal lumen [GO:0043202]	GO:0043277; GO:0045454; GO:0005783; GO:0005788; GO:0070062; GO:0043202; GO:0061024; GO:0043066; GO:0006892; GO:0003756; GO:0006457; GO:0034976	SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}.	3D-structure; Alternative splicing; Complete proteome; Disulfide bond; Endoplasmic reticulum; Redox-active center; Reference proteome; Repeat; Signal	Alternative sequence (1); Beta strand (14); Chain (1); Disulfide bond (3); Domain (3); Erroneous initiation (1); Helix (12); Motif (1); Sequence conflict (1); Signal peptide (1); Turn (6)
ANXA1_HUMAN	P04083	ANXA1_HUMAN	reviewed	Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Phospholipase A2 inhibitory protein) (p35)	ANXA1 ANX1 LPC1	Homo sapiens (Human)	346	basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; cilium [GO:0005929]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; mast cell granule [GO:0042629]; mitochondrial membrane [GO:0031966]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein complex [GO:0043234]; sarcolemma [GO:0042383]; vesicle [GO:0031982]; annealing helicase activity [GO:0036310]; calcium ion binding [GO:0005509]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; double-stranded DNA-dependent ATPase activity [GO:0033676]; helicase activity [GO:0004386]; phospholipase A2 inhibitor activity [GO:0019834]; phospholipid binding [GO:0005543]; protein binding, bridging [GO:0030674]; receptor binding [GO:0005102]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; structural molecule activity [GO:0005198]; alpha-beta T cell differentiation [GO:0046632]; arachidonic acid secretion [GO:0050482]; cell surface receptor signaling pathway [GO:0007166]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to hydrogen peroxide [GO:0070301]; DNA duplex unwinding [GO:0032508]; DNA rewinding [GO:0036292]; endocrine pancreas development [GO:0031018]; gliogenesis [GO:0042063]; hepatocyte differentiation [GO:0070365]; inflammatory response [GO:0006954]; insulin secretion [GO:0030073]; keratinocyte differentiation [GO:0030216]; movement of cell or subcellular component [GO:0006928]; negative regulation of apoptotic process [GO:0043066]; negative regulation of interleukin-8 secretion [GO:2000483]; negative regulation of phospholipase A2 activity [GO:1900138]; neutrophil clearance [GO:0097350]; neutrophil homeostasis [GO:0001780]; peptide cross-linking [GO:0018149]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of neutrophil apoptotic process [GO:0033031]; positive regulation of prostaglandin biosynthetic process [GO:0031394]; positive regulation of vesicle fusion [GO:0031340]; prolactin secretion [GO:0070459]; prostate gland development [GO:0030850]; regulation of cell proliferation [GO:0042127]; response to drug [GO:0042493]; response to estradiol [GO:0032355]; response to interleukin-1 [GO:0070555]; response to peptide hormone [GO:0043434]; response to X-ray [GO:0010165]; signal transduction [GO:0007165]	alpha-beta T cell differentiation [GO:0046632]; arachidonic acid secretion [GO:0050482]; cell surface receptor signaling pathway [GO:0007166]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to hydrogen peroxide [GO:0070301]; DNA duplex unwinding [GO:0032508]; DNA rewinding [GO:0036292]; endocrine pancreas development [GO:0031018]; gliogenesis [GO:0042063]; hepatocyte differentiation [GO:0070365]; inflammatory response [GO:0006954]; insulin secretion [GO:0030073]; keratinocyte differentiation [GO:0030216]; movement of cell or subcellular component [GO:0006928]; negative regulation of apoptotic process [GO:0043066]; negative regulation of interleukin-8 secretion [GO:2000483]; negative regulation of phospholipase A2 activity [GO:1900138]; neutrophil clearance [GO:0097350]; neutrophil homeostasis [GO:0001780]; peptide cross-linking [GO:0018149]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of neutrophil apoptotic process [GO:0033031]; positive regulation of prostaglandin biosynthetic process [GO:0031394]; positive regulation of vesicle fusion [GO:0031340]; prolactin secretion [GO:0070459]; prostate gland development [GO:0030850]; regulation of cell proliferation [GO:0042127]; response to drug [GO:0042493]; response to estradiol [GO:0032355]; response to interleukin-1 [GO:0070555]; response to peptide hormone [GO:0043434]; response to X-ray [GO:0010165]; signal transduction [GO:0007165]	annealing helicase activity [GO:0036310]; calcium-dependent phospholipid binding [GO:0005544]; calcium-dependent protein binding [GO:0048306]; calcium ion binding [GO:0005509]; double-stranded DNA-dependent ATPase activity [GO:0033676]; helicase activity [GO:0004386]; phospholipase A2 inhibitor activity [GO:0019834]; phospholipid binding [GO:0005543]; protein binding, bridging [GO:0030674]; receptor binding [GO:0005102]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; structural molecule activity [GO:0005198]	basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; cilium [GO:0005929]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; mast cell granule [GO:0042629]; mitochondrial membrane [GO:0031966]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein complex [GO:0043234]; sarcolemma [GO:0042383]; vesicle [GO:0031982]	GO:0032508; GO:0036292; GO:0046632; GO:0036310; GO:0050482; GO:0016323; GO:0005509; GO:0005544; GO:0048306; GO:0009986; GO:0007166; GO:0071385; GO:0070301; GO:0005929; GO:0001533; GO:0005737; GO:0033676; GO:0031018; GO:0005768; GO:0070062; GO:0005576; GO:0005615; GO:0005925; GO:0042063; GO:0004386; GO:0070365; GO:0006954; GO:0030073; GO:0030216; GO:0042629; GO:0031966; GO:0006928; GO:0043066; GO:2000483; GO:1900138; GO:0097350; GO:0001780; GO:0005634; GO:0018149; GO:0019834; GO:0005543; GO:0005886; GO:1900087; GO:0033031; GO:0031394; GO:0031340; GO:0070459; GO:0030850; GO:0030674; GO:0043234; GO:0005102; GO:0042127; GO:0010165; GO:0042493; GO:0032355; GO:0070555; GO:0043434; GO:0042383; GO:0007165; GO:0003697; GO:0003727; GO:0005198; GO:0031982	SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell projection, cilium {ECO:0000250}. Basolateral cell membrane {ECO:0000250}. Note=Found in the cilium, nucleus and basolateral cell membrane of ciliated cells in the tracheal endothelium. Found in the cytoplasm of type II pneumocytes and alveolar macrophages. {ECO:0000250}.	3D-structure; Acetylation; Annexin; Calcium; Calcium/phospholipid-binding; Cell membrane; Cell projection; Cilium; Complete proteome; Cytoplasm; Direct protein sequencing; Isopeptide bond; Membrane; Nucleus; Phospholipase A2 inhibitor; Phosphoprotein; Reference proteome; Repeat	Beta strand (1); Chain (1); Cross-link (1); Helix (7); Initiator methionine (1); Modified residue (9); Repeat (4)
NUDT3_HUMAN	O95989	NUDT3_HUMAN	reviewed	Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP-1) (EC 3.6.1.52) (Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1) (EC 3.6.1.-) (Nucleoside diphosphate-linked moiety X motif 3) (Nudix motif 3)	NUDT3 DIPP DIPP1	Homo sapiens (Human)	172	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; diphosphoinositol-polyphosphate diphosphatase activity [GO:0008486]; inositol diphosphate tetrakisphosphate diphosphatase activity [GO:0052840]; inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity [GO:0052846]; inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity [GO:0052847]; inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity [GO:0052843]; inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity [GO:0052848]; inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity [GO:0052844]; inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity [GO:0052845]; magnesium ion binding [GO:0000287]; cell-cell signaling [GO:0007267]; diadenosine polyphosphate catabolic process [GO:0015961]; diphosphoinositol polyphosphate catabolic process [GO:0071544]; inositol phosphate metabolic process [GO:0043647]; small molecule metabolic process [GO:0044281]	cell-cell signaling [GO:0007267]; diadenosine polyphosphate catabolic process [GO:0015961]; diphosphoinositol polyphosphate catabolic process [GO:0071544]; inositol phosphate metabolic process [GO:0043647]; small molecule metabolic process [GO:0044281]	diphosphoinositol-polyphosphate diphosphatase activity [GO:0008486]; inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity [GO:0052846]; inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity [GO:0052847]; inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity [GO:0052843]; inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity [GO:0052848]; inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity [GO:0052844]; inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity [GO:0052845]; inositol diphosphate tetrakisphosphate diphosphatase activity [GO:0052840]; magnesium ion binding [GO:0000287]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0007267; GO:0005829; GO:0015961; GO:0071544; GO:0008486; GO:0070062; GO:0052840; GO:0043647; GO:0052846; GO:0052847; GO:0052843; GO:0052848; GO:0052844; GO:0052845; GO:0000287; GO:0044281	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Hydrolase; Magnesium; Metal-binding; Reference proteome	Active site (1); Beta strand (7); Binding site (2); Chain (1); Domain (1); Helix (4); Metal binding (4); Modified residue (1); Motif (1); Mutagenesis (12); Region (2); Turn (2)
VASP_HUMAN	P50552	VASP_HUMAN	reviewed	Vasodilator-stimulated phosphoprotein (VASP)	VASP	Homo sapiens (Human)	380	actin cytoskeleton [GO:0015629]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filopodium membrane [GO:0031527]; focal adhesion [GO:0005925]; lamellipodium membrane [GO:0031258]; plasma membrane [GO:0005886]; profilin binding [GO:0005522]; actin polymerization or depolymerization [GO:0008154]; axon guidance [GO:0007411]; cell junction assembly [GO:0034329]; neural tube closure [GO:0001843]; positive regulation of actin filament polymerization [GO:0030838]; protein homotetramerization [GO:0051289]; T cell receptor signaling pathway [GO:0050852]	actin polymerization or depolymerization [GO:0008154]; axon guidance [GO:0007411]; cell junction assembly [GO:0034329]; neural tube closure [GO:0001843]; positive regulation of actin filament polymerization [GO:0030838]; protein homotetramerization [GO:0051289]; T cell receptor signaling pathway [GO:0050852]	profilin binding [GO:0005522]	actin cytoskeleton [GO:0015629]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filopodium membrane [GO:0031527]; focal adhesion [GO:0005925]; lamellipodium membrane [GO:0031258]; plasma membrane [GO:0005886]	GO:0050852; GO:0015629; GO:0008154; GO:0007411; GO:0005923; GO:0034329; GO:0005737; GO:0005829; GO:0070062; GO:0031527; GO:0005925; GO:0031258; GO:0001843; GO:0005886; GO:0030838; GO:0005522; GO:0051289	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell junction, tight junction {ECO:0000250}. Cell projection, lamellipodium membrane. Cell projection, filopodium membrane. Note=Targeted to stress fibers and focal adhesions through interaction with a number of proteins including MRL family members. Localizes to the plasma membrane in protruding lamellipodia and filopodial tips. Stimulation by thrombin or PMA, also translocates VASP to focal adhesions. Localized along the sides of actin filaments throughout the peripheral cytoplasm under basal conditions. In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes).	3D-structure; Acetylation; Actin-binding; Cell junction; Cell membrane; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; SH3-binding; Tight junction	Beta strand (8); Chain (1); Coiled coil (1); Compositional bias (4); Domain (1); Helix (3); Initiator methionine (1); Modified residue (9); Motif (1); Mutagenesis (6); Natural variant (2); Region (5); Repeat (2); Sequence conflict (2); Turn (2)
IPYR_HUMAN	Q15181	IPYR_HUMAN	reviewed	Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase)	PPA1 IOPPP PP	Homo sapiens (Human)	289	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; inorganic diphosphatase activity [GO:0004427]; magnesium ion binding [GO:0000287]; diphosphate metabolic process [GO:0071344]; gene expression [GO:0010467]; phosphate-containing compound metabolic process [GO:0006796]; tRNA aminoacylation for protein translation [GO:0006418]	diphosphate metabolic process [GO:0071344]; gene expression [GO:0010467]; phosphate-containing compound metabolic process [GO:0006796]; tRNA aminoacylation for protein translation [GO:0006418]	inorganic diphosphatase activity [GO:0004427]; magnesium ion binding [GO:0000287]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0005737; GO:0005829; GO:0071344; GO:0070062; GO:0010467; GO:0004427; GO:0000287; GO:0006796; GO:0006418	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.	Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Magnesium; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome	Chain (1); Initiator methionine (1); Metal binding (4); Modified residue (4); Natural variant (1); Sequence conflict (12)
GSK3A_HUMAN	P49840	GSK3A_HUMAN	reviewed	Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1)	GSK3A	Homo sapiens (Human)	483	beta-catenin destruction complex [GO:0030877]; cytosol [GO:0005829]; ATP binding [GO:0005524]; protein kinase A catalytic subunit binding [GO:0034236]; protein serine/threonine kinase activity [GO:0004674]; tau-protein kinase activity [GO:0050321]; cardiac left ventricle morphogenesis [GO:0003214]; cellular protein metabolic process [GO:0044267]; cellular response to insulin stimulus [GO:0032869]; cellular response to interleukin-3 [GO:0036016]; endoplasmic reticulum unfolded protein response [GO:0030968]; epidermal growth factor receptor signaling pathway [GO:0007173]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; Fc-epsilon receptor signaling pathway [GO:0038095]; fibroblast growth factor receptor signaling pathway [GO:0008543]; glycogen metabolic process [GO:0005977]; innate immune response [GO:0045087]; insulin receptor signaling pathway [GO:0008286]; IRE1-mediated unfolded protein response [GO:0036498]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; negative regulation of glucose import [GO:0046325]; negative regulation of glycogen (starch) synthase activity [GO:2000466]; negative regulation of glycogen biosynthetic process [GO:0045719]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of TOR signaling [GO:0032007]; negative regulation of transferase activity [GO:0051348]; negative regulation of type B pancreatic cell development [GO:2000077]; negative regulation of UDP-glucose catabolic process [GO:0010905]; nervous system development [GO:0007399]; neurotrophin TRK receptor signaling pathway [GO:0048011]; phosphatidylinositol-mediated signaling [GO:0048015]; positive regulation of adrenergic receptor signaling pathway [GO:0071879]; positive regulation of cAMP biosynthetic process [GO:0030819]; positive regulation of glycogen (starch) synthase activity [GO:2000467]; positive regulation of heart contraction [GO:0045823]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein targeting to mitochondrion [GO:1903955]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein phosphorylation [GO:0006468]; regulation of mitochondrion degradation [GO:1903146]; regulation of systemic arterial blood pressure [GO:0003073]; Wnt signaling pathway [GO:0016055]	cardiac left ventricle morphogenesis [GO:0003214]; cellular protein metabolic process [GO:0044267]; cellular response to insulin stimulus [GO:0032869]; cellular response to interleukin-3 [GO:0036016]; endoplasmic reticulum unfolded protein response [GO:0030968]; epidermal growth factor receptor signaling pathway [GO:0007173]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; Fc-epsilon receptor signaling pathway [GO:0038095]; fibroblast growth factor receptor signaling pathway [GO:0008543]; glycogen metabolic process [GO:0005977]; innate immune response [GO:0045087]; insulin receptor signaling pathway [GO:0008286]; IRE1-mediated unfolded protein response [GO:0036498]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; negative regulation of glucose import [GO:0046325]; negative regulation of glycogen (starch) synthase activity [GO:2000466]; negative regulation of glycogen biosynthetic process [GO:0045719]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of TOR signaling [GO:0032007]; negative regulation of transferase activity [GO:0051348]; negative regulation of type B pancreatic cell development [GO:2000077]; negative regulation of UDP-glucose catabolic process [GO:0010905]; nervous system development [GO:0007399]; neurotrophin TRK receptor signaling pathway [GO:0048011]; phosphatidylinositol-mediated signaling [GO:0048015]; positive regulation of adrenergic receptor signaling pathway [GO:0071879]; positive regulation of cAMP biosynthetic process [GO:0030819]; positive regulation of glycogen (starch) synthase activity [GO:2000467]; positive regulation of heart contraction [GO:0045823]; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein targeting to mitochondrion [GO:1903955]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein phosphorylation [GO:0006468]; regulation of mitochondrion degradation [GO:1903146]; regulation of systemic arterial blood pressure [GO:0003073]; Wnt signaling pathway [GO:0016055]	ATP binding [GO:0005524]; protein kinase A catalytic subunit binding [GO:0034236]; protein serine/threonine kinase activity [GO:0004674]; tau-protein kinase activity [GO:0050321]	beta-catenin destruction complex [GO:0030877]; cytosol [GO:0005829]	GO:0005524; GO:0038095; GO:0036498; GO:0016055; GO:0030877; GO:0003214; GO:0044267; GO:0032869; GO:0036016; GO:0005829; GO:0030968; GO:0007173; GO:0097192; GO:0008543; GO:0005977; GO:0045087; GO:0008286; GO:0032007; GO:0010905; GO:0090090; GO:0061052; GO:0046325; GO:2000466; GO:0045719; GO:0046627; GO:0051348; GO:2000077; GO:0007399; GO:0048011; GO:0048015; GO:0071879; GO:0030819; GO:2000467; GO:0045823; GO:1901030; GO:0045732; GO:1903955; GO:0043161; GO:0034236; GO:0006468; GO:0004674; GO:1903146; GO:0003073; GO:0050321		3D-structure; ATP-binding; Acetylation; Alzheimer disease; Carbohydrate metabolism; Complete proteome; Diabetes mellitus; Glycogen metabolism; Kinase; Neurogenesis; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Signal transduction inhibitor; Transferase; Wnt signaling pathway	Active site (1); Binding site (1); Chain (1); Compositional bias (1); Domain (1); Initiator methionine (1); Modified residue (9); Natural variant (2); Nucleotide binding (1); Sequence conflict (1)
4EBP1_HUMAN	Q13541	4EBP1_HUMAN	reviewed	Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I)	EIF4EBP1	Homo sapiens (Human)	118	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; protein complex [GO:0043234]; translation repressor activity [GO:0030371]; cellular protein metabolic process [GO:0044267]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; insulin receptor signaling pathway [GO:0008286]; IRES-dependent translational initiation [GO:0002192]; lung development [GO:0030324]; negative regulation of protein complex assembly [GO:0031333]; negative regulation of translational initiation [GO:0045947]; positive regulation of mitotic cell cycle [GO:0045931]; response to ethanol [GO:0045471]; response to ischemia [GO:0002931]; TOR signaling [GO:0031929]; translation [GO:0006412]; translational initiation [GO:0006413]	cellular protein metabolic process [GO:0044267]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; insulin receptor signaling pathway [GO:0008286]; IRES-dependent translational initiation [GO:0002192]; lung development [GO:0030324]; negative regulation of protein complex assembly [GO:0031333]; negative regulation of translational initiation [GO:0045947]; positive regulation of mitotic cell cycle [GO:0045931]; response to ethanol [GO:0045471]; response to ischemia [GO:0002931]; TOR signaling [GO:0031929]; translation [GO:0006412]; translational initiation [GO:0006413]	translation repressor activity [GO:0030371]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; protein complex [GO:0043234]	GO:0000082; GO:0002192; GO:0031929; GO:0044267; GO:0005737; GO:0005829; GO:0010467; GO:0008286; GO:0030324; GO:0031333; GO:0045947; GO:0005654; GO:0045931; GO:0043234; GO:0045471; GO:0002931; GO:0006412; GO:0030371; GO:0006413		3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Isopeptide bond; Phosphoprotein; Protein synthesis inhibitor; Reference proteome; Translation regulation; Ubl conjugation	Chain (1); Cross-link (1); Helix (3); Initiator methionine (1); Modified residue (12); Motif (2); Mutagenesis (8); Turn (1)
OFUT2_HUMAN	Q9Y2G5	OFUT2_HUMAN	reviewed	GDP-fucose protein O-fucosyltransferase 2 (EC 2.4.1.221) (Peptide-O-fucosyltransferase 2) (O-FucT-2)	POFUT2 C21orf80 FUT13 KIAA0958	Homo sapiens (Human)	429	endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; peptide-O-fucosyltransferase activity [GO:0046922]; cellular protein metabolic process [GO:0044267]; fucose metabolic process [GO:0006004]; mesoderm formation [GO:0001707]; post-translational protein modification [GO:0043687]; protein O-linked fucosylation [GO:0036066]; protein O-linked glycosylation [GO:0006493]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gene expression [GO:0010468]; regulation of secretion [GO:0051046]	cellular protein metabolic process [GO:0044267]; fucose metabolic process [GO:0006004]; mesoderm formation [GO:0001707]; post-translational protein modification [GO:0043687]; protein O-linked fucosylation [GO:0036066]; protein O-linked glycosylation [GO:0006493]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gene expression [GO:0010468]; regulation of secretion [GO:0051046]	peptide-O-fucosyltransferase activity [GO:0046922]	endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]	GO:0005794; GO:0044267; GO:0005789; GO:0006004; GO:0001707; GO:0046922; GO:0043687; GO:0036066; GO:0006493; GO:0010717; GO:0010468; GO:0051046	SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:15233996}. Golgi apparatus {ECO:0000269|PubMed:15233996}. Note=Mainly located in the endoplasmic reticulum.	3D-structure; Alternative splicing; Carbohydrate metabolism; Complete proteome; Disulfide bond; Endoplasmic reticulum; Fucose metabolism; Glycoprotein; Glycosyltransferase; Golgi apparatus; Reference proteome; Signal; Transferase	Active site (1); Alternative sequence (3); Beta strand (12); Binding site (1); Chain (1); Disulfide bond (2); Erroneous initiation (2); Glycosylation (3); Helix (17); Mutagenesis (8); Region (2); Signal peptide (1); Site (1); Turn (2)
E9PJT1_HUMAN	E9PJT1	E9PJT1_HUMAN	unreviewed	Phosphatidylinositol-binding clathrin assembly protein	PICALM	Homo sapiens (Human)	48							Complete proteome; Proteomics identification; Reference proteome	
COX5A_HUMAN	P20674	COX5A_HUMAN	reviewed	Cytochrome c oxidase subunit 5A, mitochondrial (Cytochrome c oxidase polypeptide Va)	COX5A	Homo sapiens (Human)	150	extracellular exosome [GO:0070062]; mitochondrial inner membrane [GO:0005743]; cytochrome-c oxidase activity [GO:0004129]; electron carrier activity [GO:0009055]; metal ion binding [GO:0046872]; cellular metabolic process [GO:0044237]; gene expression [GO:0010467]; hydrogen ion transmembrane transport [GO:1902600]; respiratory electron transport chain [GO:0022904]; small molecule metabolic process [GO:0044281]; transcription initiation from RNA polymerase II promoter [GO:0006367]	cellular metabolic process [GO:0044237]; gene expression [GO:0010467]; hydrogen ion transmembrane transport [GO:1902600]; respiratory electron transport chain [GO:0022904]; small molecule metabolic process [GO:0044281]; transcription initiation from RNA polymerase II promoter [GO:0006367]	cytochrome-c oxidase activity [GO:0004129]; electron carrier activity [GO:0009055]; metal ion binding [GO:0046872]	extracellular exosome [GO:0070062]; mitochondrial inner membrane [GO:0005743]	GO:0044237; GO:0004129; GO:0009055; GO:0070062; GO:0010467; GO:1902600; GO:0046872; GO:0005743; GO:0022904; GO:0044281; GO:0006367	SUBCELLULAR LOCATION: Mitochondrion inner membrane.	Acetylation; Complete proteome; Direct protein sequencing; Heme; Iron; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Phosphoprotein; Reference proteome; Transit peptide	Chain (1); Modified residue (3); Sequence conflict (1); Transit peptide (1)
TWF1_HUMAN	Q12792	TWF1_HUMAN	reviewed	Twinfilin-1 (Protein A6) (Protein tyrosine kinase 9)	TWF1 PTK9	Homo sapiens (Human)	350	actin cytoskeleton [GO:0015629]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; myofibril [GO:0030016]; perinuclear region of cytoplasm [GO:0048471]; actin monomer binding [GO:0003785]; ATP binding [GO:0005524]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; negative regulation of actin filament polymerization [GO:0030837]; regulation of actin phosphorylation [GO:0043538]; sequestering of actin monomers [GO:0042989]	negative regulation of actin filament polymerization [GO:0030837]; regulation of actin phosphorylation [GO:0043538]; sequestering of actin monomers [GO:0042989]	actin monomer binding [GO:0003785]; ATP binding [GO:0005524]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]	actin cytoskeleton [GO:0015629]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; myofibril [GO:0030016]; perinuclear region of cytoplasm [GO:0048471]	GO:0005524; GO:0015629; GO:0003785; GO:0005911; GO:0005737; GO:0030175; GO:0005925; GO:0030016; GO:0030837; GO:0048471; GO:0005546; GO:0043538; GO:0042989	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts (By similarity). {ECO:0000250}.	Acetylation; Actin-binding; Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Phosphoprotein; Reference proteome; Repeat	Alternative sequence (2); Chain (1); Domain (2); Erroneous initiation (3); Initiator methionine (1); Modified residue (4); Sequence conflict (5)
ERH_HUMAN	P84090	ERH_HUMAN	reviewed	Enhancer of rudimentary homolog	ERH	Homo sapiens (Human)	104	membrane [GO:0016020]; midbody [GO:0030496]; poly(A) RNA binding [GO:0044822]; cell cycle [GO:0007049]; nucleobase-containing compound metabolic process [GO:0006139]; osteoblast differentiation [GO:0001649]; positive regulation of Notch signaling pathway [GO:0045747]; pyrimidine nucleoside metabolic process [GO:0006213]; pyrimidine nucleotide biosynthetic process [GO:0006221]	cell cycle [GO:0007049]; nucleobase-containing compound metabolic process [GO:0006139]; osteoblast differentiation [GO:0001649]; positive regulation of Notch signaling pathway [GO:0045747]; pyrimidine nucleoside metabolic process [GO:0006213]; pyrimidine nucleotide biosynthetic process [GO:0006221]	poly(A) RNA binding [GO:0044822]	membrane [GO:0016020]; midbody [GO:0030496]	GO:0007049; GO:0016020; GO:0030496; GO:0006139; GO:0001649; GO:0044822; GO:0045747; GO:0006213; GO:0006221		3D-structure; Acetylation; Cell cycle; Complete proteome; Direct protein sequencing; Reference proteome	Beta strand (4); Chain (1); Helix (4); Initiator methionine (1); Modified residue (1); Turn (1)
SMU1_HUMAN	Q2TAY7	SMU1_HUMAN	reviewed	WD40 repeat-containing protein SMU1 (Smu-1 suppressor of mec-8 and unc-52 protein homolog) [Cleaved into: WD40 repeat-containing protein SMU1, N-terminally processed]	SMU1	Homo sapiens (Human)	513	cytoplasm [GO:0005737]; nucleus [GO:0005634]			cytoplasm [GO:0005737]; nucleus [GO:0005634]	GO:0005737; GO:0005634	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.	Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Reference proteome; Repeat; WD repeat	Alternative sequence (1); Chain (2); Domain (2); Initiator methionine (1); Modified residue (2); Repeat (6); Sequence conflict (5)
MNT_HUMAN	Q99583	MNT_HUMAN	reviewed	Max-binding protein MNT (Class D basic helix-loop-helix protein 3) (bHLHd3) (Myc antagonist MNT) (Protein ROX)	MNT BHLHD3 ROX	Homo sapiens (Human)	582	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [GO:0001227]; sequence-specific DNA binding transcription factor activity [GO:0003700]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; cell aging [GO:0007569]; multicellular organismal development [GO:0007275]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of cell proliferation [GO:0008285]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; regulation of cell cycle [GO:0051726]; transcription from RNA polymerase II promoter [GO:0006366]	cell aging [GO:0007569]; multicellular organismal development [GO:0007275]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of cell proliferation [GO:0008285]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; regulation of cell cycle [GO:0051726]; transcription from RNA polymerase II promoter [GO:0006366]	chromatin binding [GO:0003682]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [GO:0001227]; sequence-specific DNA binding transcription factor activity [GO:0003700]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0000977; GO:0001227; GO:0007569; GO:0003682; GO:0007275; GO:2001234; GO:0008285; GO:0000122; GO:0005654; GO:0005634; GO:0051726; GO:0003700; GO:0003713; GO:0003714; GO:0006366	SUBCELLULAR LOCATION: Nucleus.	Acetylation; Complete proteome; DNA-binding; Nucleus; Polymorphism; Reference proteome; Repressor; Transcription; Transcription regulation	Chain (1); Domain (1); Initiator methionine (1); Modified residue (1); Natural variant (1); Region (1)
ENOPH_HUMAN	Q9UHY7	ENOPH_HUMAN	reviewed	Enolase-phosphatase E1 (EC 3.1.3.77) (2,3-diketo-5-methylthio-1-phosphopentane phosphatase) (MASA homolog)	ENOPH1 MASA MSTP145	Homo sapiens (Human)	261	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; acireductone synthase activity [GO:0043874]; magnesium ion binding [GO:0000287]; cellular nitrogen compound metabolic process [GO:0034641]; dephosphorylation [GO:0016311]; L-methionine biosynthetic process from methylthioadenosine [GO:0019509]; polyamine metabolic process [GO:0006595]; small molecule metabolic process [GO:0044281]; sulfur amino acid metabolic process [GO:0000096]	cellular nitrogen compound metabolic process [GO:0034641]; dephosphorylation [GO:0016311]; L-methionine biosynthetic process from methylthioadenosine [GO:0019509]; polyamine metabolic process [GO:0006595]; small molecule metabolic process [GO:0044281]; sulfur amino acid metabolic process [GO:0000096]	acireductone synthase activity [GO:0043874]; magnesium ion binding [GO:0000287]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	GO:0019509; GO:0043874; GO:0034641; GO:0005829; GO:0016311; GO:0070062; GO:0000287; GO:0005634; GO:0006595; GO:0044281; GO:0000096	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03117}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03117}.	3D-structure; Alternative splicing; Amino-acid biosynthesis; Complete proteome; Cytoplasm; Hydrolase; Magnesium; Metal-binding; Methionine biosynthesis; Nucleus; Reference proteome	Alternative sequence (1); Beta strand (6); Binding site (1); Chain (1); Frameshift (1); Helix (14); Metal binding (3); Region (1); Turn (2)
TBL1R_HUMAN	Q9BZK7	TBL1R_HUMAN	reviewed	F-box-like/WD repeat-containing protein TBL1XR1 (Nuclear receptor corepressor/HDAC3 complex subunit TBLR1) (TBL1-related protein 1) (Transducin beta-like 1X-related protein 1)	TBL1XR1 IRA1 TBLR1	Homo sapiens (Human)	514	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle microtubule [GO:0005876]; transcriptional repressor complex [GO:0017053]; beta-catenin binding [GO:0008013]; histone binding [GO:0042393]; protein N-terminus binding [GO:0047485]; transcription corepressor activity [GO:0003714]; transcription regulatory region DNA binding [GO:0044212]; canonical Wnt signaling pathway [GO:0060070]; cellular lipid metabolic process [GO:0044255]; chromatin organization [GO:0006325]; histone deacetylation [GO:0016575]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; Notch signaling pathway [GO:0007219]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; small molecule metabolic process [GO:0044281]; transcription, DNA-templated [GO:0006351]	canonical Wnt signaling pathway [GO:0060070]; cellular lipid metabolic process [GO:0044255]; chromatin organization [GO:0006325]; histone deacetylation [GO:0016575]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; Notch signaling pathway [GO:0007219]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; small molecule metabolic process [GO:0044281]; transcription, DNA-templated [GO:0006351]	beta-catenin binding [GO:0008013]; histone binding [GO:0042393]; protein N-terminus binding [GO:0047485]; transcription corepressor activity [GO:0003714]; transcription regulatory region DNA binding [GO:0044212]	nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle microtubule [GO:0005876]; transcriptional repressor complex [GO:0017053]	GO:0007219; GO:0008013; GO:0060070; GO:0044255; GO:0006325; GO:0042393; GO:0016575; GO:0000122; GO:0005654; GO:0005634; GO:0045944; GO:0045893; GO:0043161; GO:0047485; GO:0044281; GO:0005876; GO:0003714; GO:0044212; GO:0006351; GO:0017053	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.	3D-structure; Acetylation; Activator; Chromatin regulator; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Ubl conjugation pathway; WD repeat	Beta strand (32); Chain (1); Compositional bias (1); Domain (2); Helix (1); Initiator methionine (1); Modified residue (3); Repeat (8); Sequence caution (1); Sequence conflict (3); Turn (3)
SEPT3_HUMAN	Q9UH03	SEPT3_HUMAN	reviewed	Neuronal-specific septin-3	SEPT3 SEP3	Homo sapiens (Human)	358	cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; synapse [GO:0045202]; GTP binding [GO:0005525]; cell cycle [GO:0007049]; cell division [GO:0051301]	cell cycle [GO:0007049]; cell division [GO:0051301]	GTP binding [GO:0005525]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; synapse [GO:0045202]	GO:0005525; GO:0007049; GO:0051301; GO:0030054; GO:0005737; GO:0005856; GO:0045202	SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Cell junction, synapse {ECO:0000250}.	3D-structure; Alternative splicing; Cell cycle; Cell division; Cell junction; Complete proteome; Cytoplasm; Cytoskeleton; GTP-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Synapse	Alternative sequence (3); Beta strand (10); Binding site (3); Chain (1); Domain (1); Erroneous initiation (6); Helix (9); Modified residue (1); Nucleotide binding (2); Turn (2)
A8MXP9_HUMAN	A8MXP9	A8MXP9_HUMAN	unreviewed	Matrin-3	MATR3	Homo sapiens (Human)	895	nucleoplasm [GO:0005654]; nucleic acid binding [GO:0003676]; nucleotide binding [GO:0000166]; zinc ion binding [GO:0008270]		nucleic acid binding [GO:0003676]; nucleotide binding [GO:0000166]; zinc ion binding [GO:0008270]	nucleoplasm [GO:0005654]	GO:0003676; GO:0005654; GO:0000166; GO:0008270		Complete proteome; Nucleus; Proteomics identification; Reference proteome	
MATR3_HUMAN	P43243	MATR3_HUMAN	reviewed	Matrin-3	MATR3 KIAA0723	Homo sapiens (Human)	847	membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; structural molecule activity [GO:0005198]; zinc ion binding [GO:0008270]; posttranscriptional regulation of gene expression [GO:0010608]	posttranscriptional regulation of gene expression [GO:0010608]	nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; structural molecule activity [GO:0005198]; zinc ion binding [GO:0008270]	membrane [GO:0016020]; nuclear inner membrane [GO:0005637]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]	GO:0016020; GO:0005637; GO:0016363; GO:0005654; GO:0000166; GO:0044822; GO:0010608; GO:0005198; GO:0008270	SUBCELLULAR LOCATION: Nucleus matrix.	Acetylation; Alternative splicing; Amyotrophic lateral sclerosis; Complete proteome; Direct protein sequencing; Disease mutation; Metal-binding; Neurodegeneration; Nucleus; Phosphoprotein; RNA-binding; Reference proteome; Repeat; Zinc; Zinc-finger	Alternative sequence (1); Chain (1); Domain (2); Erroneous initiation (1); Frameshift (1); Initiator methionine (1); Modified residue (31); Motif (1); Natural variant (4); Sequence conflict (6); Zinc finger (1)
IF2A_HUMAN	P05198	IF2A_HUMAN	reviewed	Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha)	EIF2S1 EIF2A	Homo sapiens (Human)	315	cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 2 complex [GO:0005850]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; multi-eIF complex [GO:0043614]; nucleus [GO:0005634]; polysome [GO:0005844]; ribosome [GO:0005840]; poly(A) RNA binding [GO:0044822]; ribosome binding [GO:0043022]; translation initiation factor activity [GO:0003743]; activation of mitophagy in response to mitochondrial depolarization [GO:0098779]; cellular protein metabolic process [GO:0044267]; endoplasmic reticulum unfolded protein response [GO:0030968]; gene expression [GO:0010467]; PERK-mediated unfolded protein response [GO:0036499]; positive regulation of defense response to virus by host [GO:0002230]; protein autophosphorylation [GO:0046777]; regulation of translational initiation in response to stress [GO:0043558]; translation [GO:0006412]; translational initiation [GO:0006413]; transmembrane transport [GO:0055085]	activation of mitophagy in response to mitochondrial depolarization [GO:0098779]; cellular protein metabolic process [GO:0044267]; endoplasmic reticulum unfolded protein response [GO:0030968]; gene expression [GO:0010467]; PERK-mediated unfolded protein response [GO:0036499]; positive regulation of defense response to virus by host [GO:0002230]; protein autophosphorylation [GO:0046777]; regulation of translational initiation in response to stress [GO:0043558]; translation [GO:0006412]; translational initiation [GO:0006413]; transmembrane transport [GO:0055085]	poly(A) RNA binding [GO:0044822]; ribosome binding [GO:0043022]; translation initiation factor activity [GO:0003743]	cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 2 complex [GO:0005850]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; multi-eIF complex [GO:0043614]; nucleus [GO:0005634]; polysome [GO:0005844]; ribosome [GO:0005840]	GO:0036499; GO:0098779; GO:0044267; GO:0010494; GO:0005829; GO:0030968; GO:0033290; GO:0005850; GO:0070062; GO:0010467; GO:0016020; GO:0043614; GO:0005634; GO:0044822; GO:0005844; GO:0002230; GO:0046777; GO:0043558; GO:0005840; GO:0043022; GO:0006412; GO:0003743; GO:0006413; GO:0055085	SUBCELLULAR LOCATION: Cytoplasmic granule {ECO:0000250}. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity). {ECO:0000250}.	3D-structure; Acetylation; Complete proteome; Initiation factor; Phosphoprotein; Protein biosynthesis; RNA-binding; Reference proteome; Translation regulation	Beta strand (11); Chain (1); Domain (1); Helix (11); Modified residue (3); Turn (4)
SMC2_HUMAN	O95347	SMC2_HUMAN	reviewed	Structural maintenance of chromosomes protein 2 (SMC protein 2) (SMC-2) (Chromosome-associated protein E) (hCAP-E) (XCAP-E homolog)	SMC2 CAPE SMC2L1 PRO0324	Homo sapiens (Human)	1197	condensed chromosome [GO:0000793]; condensin complex [GO:0000796]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; protein heterodimerization activity [GO:0046982]; cell division [GO:0051301]; kinetochore organization [GO:0051383]; meiotic chromosome condensation [GO:0010032]; meiotic chromosome segregation [GO:0045132]; mitotic cell cycle [GO:0000278]; mitotic chromosome condensation [GO:0007076]	cell division [GO:0051301]; kinetochore organization [GO:0051383]; meiotic chromosome condensation [GO:0010032]; meiotic chromosome segregation [GO:0045132]; mitotic cell cycle [GO:0000278]; mitotic chromosome condensation [GO:0007076]	ATP binding [GO:0005524]; protein heterodimerization activity [GO:0046982]	condensed chromosome [GO:0000793]; condensin complex [GO:0000796]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005524; GO:0051301; GO:0000793; GO:0000796; GO:0005737; GO:0005829; GO:0070062; GO:0051383; GO:0010032; GO:0045132; GO:0000278; GO:0007076; GO:0000228; GO:0005654; GO:0005634; GO:0046982	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958694}. Cytoplasm {ECO:0000269|PubMed:10958694}. Chromosome {ECO:0000269|PubMed:10958694}. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.	ATP-binding; Acetylation; Alternative splicing; Cell cycle; Cell division; Chromosome; Coiled coil; Complete proteome; Cytoplasm; DNA condensation; Mitosis; Nucleotide-binding; Nucleus; Polymorphism; Reference proteome	Alternative sequence (2); Chain (1); Coiled coil (3); Compositional bias (1); Erroneous initiation (1); Frameshift (1); Modified residue (5); Natural variant (1); Nucleotide binding (1); Region (1); Sequence conflict (3)
ARC1A_HUMAN	Q92747	ARC1A_HUMAN	reviewed	Actin-related protein 2/3 complex subunit 1A (SOP2-like protein)	ARPC1A SOP2L	Homo sapiens (Human)	370	actin cytoskeleton [GO:0015629]; Arp2/3 protein complex [GO:0005885]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; actin cytoskeleton organization [GO:0030036]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; axon guidance [GO:0007411]; ephrin receptor signaling pathway [GO:0048013]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; innate immune response [GO:0045087]; small GTPase mediated signal transduction [GO:0007264]	actin cytoskeleton organization [GO:0030036]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; axon guidance [GO:0007411]; ephrin receptor signaling pathway [GO:0048013]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; innate immune response [GO:0045087]; small GTPase mediated signal transduction [GO:0007264]	actin binding [GO:0003779]; actin filament binding [GO:0051015]	actin cytoskeleton [GO:0015629]; Arp2/3 protein complex [GO:0005885]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0034314; GO:0005885; GO:0038096; GO:0003779; GO:0015629; GO:0030036; GO:0051015; GO:0007411; GO:0005829; GO:0048013; GO:0070062; GO:0045087; GO:0007264	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.	Acetylation; Actin-binding; Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Reference proteome; Repeat; WD repeat	Alternative sequence (2); Chain (1); Initiator methionine (1); Modified residue (1); Repeat (6); Sequence conflict (3)
J3KNF4_HUMAN	J3KNF4	J3KNF4_HUMAN	unreviewed	Copper chaperone for superoxide dismutase	CCS	Homo sapiens (Human)	255	superoxide dismutase activity [GO:0004784]; zinc ion binding [GO:0008270]; metal ion transport [GO:0030001]; removal of superoxide radicals [GO:0019430]	metal ion transport [GO:0030001]; removal of superoxide radicals [GO:0019430]	superoxide dismutase activity [GO:0004784]; zinc ion binding [GO:0008270]		GO:0030001; GO:0019430; GO:0004784; GO:0008270		Complete proteome; Proteomics identification; Reference proteome	
CCS_HUMAN	O14618	CCS_HUMAN	reviewed	Copper chaperone for superoxide dismutase (Superoxide dismutase copper chaperone)	CCS	Homo sapiens (Human)	274	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; copper ion binding [GO:0005507]; copper ion transmembrane transporter activity [GO:0005375]; protein disulfide oxidoreductase activity [GO:0015035]; superoxide dismutase activity [GO:0004784]; zinc ion binding [GO:0008270]; copper ion transmembrane transport [GO:0035434]; intracellular copper ion transport [GO:0015680]; positive regulation of oxidoreductase activity [GO:0051353]; removal of superoxide radicals [GO:0019430]; response to reactive oxygen species [GO:0000302]; superoxide metabolic process [GO:0006801]	copper ion transmembrane transport [GO:0035434]; intracellular copper ion transport [GO:0015680]; positive regulation of oxidoreductase activity [GO:0051353]; removal of superoxide radicals [GO:0019430]; response to reactive oxygen species [GO:0000302]; superoxide metabolic process [GO:0006801]	copper ion binding [GO:0005507]; copper ion transmembrane transporter activity [GO:0005375]; protein disulfide oxidoreductase activity [GO:0015035]; superoxide dismutase activity [GO:0004784]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]	GO:0005507; GO:0035434; GO:0005375; GO:0005737; GO:0005829; GO:0015680; GO:0005634; GO:0051353; GO:0015035; GO:0019430; GO:0000302; GO:0004784; GO:0006801; GO:0008270	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9726962}.	3D-structure; Chaperone; Complete proteome; Copper; Cytoplasm; Disulfide bond; Isopeptide bond; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation; Zinc	Beta strand (15); Chain (1); Cross-link (4); Disulfide bond (1); Domain (1); Helix (4); Metal binding (8); Modified residue (1); Mutagenesis (4); Natural variant (1); Region (1); Sequence conflict (1); Turn (4)
D6RA00_HUMAN	D6RA00	D6RA00_HUMAN	unreviewed	Enolase-phosphatase E1	ENOPH1	Homo sapiens (Human)	173	acireductone synthase activity [GO:0043874]; magnesium ion binding [GO:0000287]; L-methionine biosynthetic process from methylthioadenosine [GO:0019509]	L-methionine biosynthetic process from methylthioadenosine [GO:0019509]	acireductone synthase activity [GO:0043874]; magnesium ion binding [GO:0000287]		GO:0019509; GO:0043874; GO:0000287		Complete proteome; Proteomics identification; Reference proteome	
IF4B_HUMAN	P23588	IF4B_HUMAN	reviewed	Eukaryotic translation initiation factor 4B (eIF-4B)	EIF4B	Homo sapiens (Human)	611	cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]; nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]; cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; insulin receptor signaling pathway [GO:0008286]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; regulation of translational initiation [GO:0006446]; translation [GO:0006412]; translational initiation [GO:0006413]	cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; insulin receptor signaling pathway [GO:0008286]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; regulation of translational initiation [GO:0006446]; translation [GO:0006412]; translational initiation [GO:0006413]	nucleotide binding [GO:0000166]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; translation initiation factor activity [GO:0003743]	cytosol [GO:0005829]; eukaryotic translation initiation factor 4F complex [GO:0016281]	GO:0003723; GO:0044267; GO:0005829; GO:0016281; GO:0010467; GO:0008286; GO:0000288; GO:0000289; GO:0000166; GO:0044822; GO:0006446; GO:0006412; GO:0003743; GO:0006413		3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Initiation factor; Phosphoprotein; Polymorphism; Protein biosynthesis; RNA-binding; Reference proteome	Alternative sequence (1); Beta strand (5); Chain (1); Compositional bias (2); Domain (1); Helix (3); Modified residue (17); Natural variant (1); Sequence conflict (7); Turn (2)
CAPR1_HUMAN	Q14444	CAPR1_HUMAN	reviewed	Caprin-1 (Cell cycle-associated protein 1) (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (Membrane component chromosome 11 surface marker 1) (RNA granule protein 105)	CAPRIN1 GPIAP1 GPIP137 M11S1 RNG105	Homo sapiens (Human)	709	cytoplasm [GO:0005737]; cytoplasmic mRNA processing body [GO:0000932]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; negative regulation of translation [GO:0017148]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]	negative regulation of translation [GO:0017148]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of dendritic spine morphogenesis [GO:0061003]	poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytoplasmic mRNA processing body [GO:0000932]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]	GO:0003723; GO:0005737; GO:0000932; GO:0010494; GO:0005829; GO:0030425; GO:0005887; GO:0016020; GO:0017148; GO:0044822; GO:0050775; GO:0061003	SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cell projection, dendrite. Note=Associated with RNA granules. {ECO:0000250}.	Acetylation; Alternative splicing; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Differentiation; Direct protein sequencing; Glycoprotein; Phosphoprotein; Polymorphism; Protein synthesis inhibitor; RNA-binding; Reference proteome	Alternative sequence (1); Chain (1); Coiled coil (2); Erroneous gene model prediction (1); Frameshift (1); Initiator methionine (1); Modified residue (4); Mutagenesis (3); Natural variant (3); Region (1); Sequence conflict (1)
H9ZYI9_HUMAN	H9ZYI9	H9ZYI9_HUMAN	unreviewed	GA binding protein transcription factor beta subunit 1 transcript variant gamma-2 (GA binding protein transcription factor, beta subunit 2, isoform CRA_c) (GA-binding protein subunit beta-1)	GABPB1 GABPB2 hCG_2002404	Homo sapiens (Human)	347							ANK repeat; Complete proteome; Proteomics identification; Reference proteome; Repeat	
RFC3_HUMAN	P40938	RFC3_HUMAN	reviewed	Replication factor C subunit 3 (Activator 1 38 kDa subunit) (A1 38 kDa subunit) (Activator 1 subunit 3) (Replication factor C 38 kDa subunit) (RF-C 38 kDa subunit) (RFC38)	RFC3	Homo sapiens (Human)	356	DNA replication factor C complex [GO:0005663]; nucleoplasm [GO:0005654]; DNA clamp loader activity [GO:0003689]; base-excision repair [GO:0006284]; DNA damage response, detection of DNA damage [GO:0042769]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA synthesis involved in DNA repair [GO:0000731]; DNA-dependent DNA replication [GO:0006261]; error-free translesion synthesis [GO:0070987]; error-prone translesion synthesis [GO:0042276]; mitotic cell cycle [GO:0000278]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair, DNA gap filling [GO:0006297]; response to organophosphorus [GO:0046683]; telomere maintenance [GO:0000723]; telomere maintenance via recombination [GO:0000722]; telomere maintenance via semi-conservative replication [GO:0032201]; transcription-coupled nucleotide-excision repair [GO:0006283]; translesion synthesis [GO:0019985]	base-excision repair [GO:0006284]; DNA damage response, detection of DNA damage [GO:0042769]; DNA-dependent DNA replication [GO:0006261]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA synthesis involved in DNA repair [GO:0000731]; error-free translesion synthesis [GO:0070987]; error-prone translesion synthesis [GO:0042276]; mitotic cell cycle [GO:0000278]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair, DNA gap filling [GO:0006297]; response to organophosphorus [GO:0046683]; telomere maintenance [GO:0000723]; telomere maintenance via recombination [GO:0000722]; telomere maintenance via semi-conservative replication [GO:0032201]; transcription-coupled nucleotide-excision repair [GO:0006283]; translesion synthesis [GO:0019985]	DNA clamp loader activity [GO:0003689]	DNA replication factor C complex [GO:0005663]; nucleoplasm [GO:0005654]	GO:0003689; GO:0042769; GO:0006281; GO:0006260; GO:0005663; GO:0006271; GO:0000731; GO:0006261; GO:0006284; GO:0070987; GO:0042276; GO:0000278; GO:0005654; GO:0006289; GO:0006297; GO:0046683; GO:0000723; GO:0000722; GO:0032201; GO:0006283; GO:0019985	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.	Acetylation; Alternative splicing; Complete proteome; DNA replication; DNA-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome	Alternative sequence (1); Chain (1); Modified residue (2); Natural variant (1)
TXNL1_HUMAN	O43396	TXNL1_HUMAN	reviewed	Thioredoxin-like protein 1 (32 kDa thioredoxin-related protein)	TXNL1 TRP32 TXL TXNL	Homo sapiens (Human)	289	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; disulfide oxidoreductase activity [GO:0015036]; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [GO:0016671]; protein disulfide oxidoreductase activity [GO:0015035]; cell redox homeostasis [GO:0045454]; cellular response to oxidative stress [GO:0034599]; glycerol ether metabolic process [GO:0006662]; oxidation-reduction process [GO:0055114]; protein folding [GO:0006457]; sulfate assimilation [GO:0000103]	cell redox homeostasis [GO:0045454]; cellular response to oxidative stress [GO:0034599]; glycerol ether metabolic process [GO:0006662]; oxidation-reduction process [GO:0055114]; protein folding [GO:0006457]; sulfate assimilation [GO:0000103]	disulfide oxidoreductase activity [GO:0015036]; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [GO:0016671]; protein disulfide oxidoreductase activity [GO:0015035]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; proteasome complex [GO:0000502]	GO:0045454; GO:0034599; GO:0005737; GO:0015036; GO:0070062; GO:0006662; GO:0005634; GO:0055114; GO:0016671; GO:0000502; GO:0015035; GO:0006457; GO:0000103	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19349277}. Nucleus {ECO:0000269|PubMed:19349277}. Note=At least 85% of the cellular TXNL1 is proteasome-associated.	3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; Electron transport; Nucleus; Proteasome; Redox-active center; Reference proteome; Transport	Beta strand (13); Chain (1); Disulfide bond (1); Domain (2); Helix (7); Initiator methionine (1); Turn (5)
P5CS_HUMAN	P54886	P5CS_HUMAN	reviewed	Delta-1-pyrroline-5-carboxylate synthase (P5CS) (Aldehyde dehydrogenase family 18 member A1) [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)]	ALDH18A1 GSAS P5CS PYCS	Homo sapiens (Human)	795	cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; glutamate 5-kinase activity [GO:0004349]; glutamate-5-semialdehyde dehydrogenase activity [GO:0004350]; poly(A) RNA binding [GO:0044822]; cellular amino acid biosynthetic process [GO:0008652]; cellular nitrogen compound metabolic process [GO:0034641]; citrulline biosynthetic process [GO:0019240]; glutamate metabolic process [GO:0006536]; L-proline biosynthetic process [GO:0055129]; ornithine biosynthetic process [GO:0006592]; proline biosynthetic process [GO:0006561]; small molecule metabolic process [GO:0044281]	cellular amino acid biosynthetic process [GO:0008652]; cellular nitrogen compound metabolic process [GO:0034641]; citrulline biosynthetic process [GO:0019240]; glutamate metabolic process [GO:0006536]; L-proline biosynthetic process [GO:0055129]; ornithine biosynthetic process [GO:0006592]; proline biosynthetic process [GO:0006561]; small molecule metabolic process [GO:0044281]	ATP binding [GO:0005524]; glutamate 5-kinase activity [GO:0004349]; glutamate-5-semialdehyde dehydrogenase activity [GO:0004350]; poly(A) RNA binding [GO:0044822]	cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]	GO:0005524; GO:0055129; GO:0008652; GO:0034641; GO:0019240; GO:0005737; GO:0004349; GO:0006536; GO:0004350; GO:0005743; GO:0005739; GO:0006592; GO:0044822; GO:0006561; GO:0044281	SUBCELLULAR LOCATION: Mitochondrion inner membrane.	3D-structure; ATP-binding; Alternative splicing; Amino-acid biosynthesis; Complete proteome; Disease mutation; Kinase; Membrane; Mental retardation; Mitochondrion; Mitochondrion inner membrane; Multifunctional enzyme; NADP; Nucleotide-binding; Oxidoreductase; Polymorphism; Proline biosynthesis; Reference proteome; Transferase	Alternative sequence (1); Beta strand (15); Binding site (3); Chain (1); Erroneous initiation (2); Helix (19); Modified residue (3); Natural variant (4); Nucleotide binding (2); Region (2); Sequence conflict (7); Turn (4)
CUL3_HUMAN	Q13618	CUL3_HUMAN	reviewed	Cullin-3 (CUL-3)	CUL3 KIAA0617	Homo sapiens (Human)	768	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; polar microtubule [GO:0005827]; POZ domain binding [GO:0031208]; cell cycle arrest [GO:0007050]; cell migration [GO:0016477]; COPII vesicle coating [GO:0048208]; embryonic cleavage [GO:0040016]; ER to Golgi vesicle-mediated transport [GO:0006888]; G1/S transition of mitotic cell cycle [GO:0000082]; gastrulation [GO:0007369]; integrin-mediated signaling pathway [GO:0007229]; intrinsic apoptotic signaling pathway [GO:0097193]; mitotic metaphase plate congression [GO:0007080]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation [GO:0008054]; negative regulation of Rho protein signal transduction [GO:0035024]; positive regulation of cell proliferation [GO:0008284]; positive regulation of cytokinesis [GO:0032467]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; stem cell division [GO:0017145]; stress fiber assembly [GO:0043149]; trophectodermal cellular morphogenesis [GO:0001831]; Wnt signaling pathway [GO:0016055]	cell cycle arrest [GO:0007050]; cell migration [GO:0016477]; COPII vesicle coating [GO:0048208]; embryonic cleavage [GO:0040016]; ER to Golgi vesicle-mediated transport [GO:0006888]; G1/S transition of mitotic cell cycle [GO:0000082]; gastrulation [GO:0007369]; integrin-mediated signaling pathway [GO:0007229]; intrinsic apoptotic signaling pathway [GO:0097193]; mitotic metaphase plate congression [GO:0007080]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation [GO:0008054]; negative regulation of Rho protein signal transduction [GO:0035024]; positive regulation of cell proliferation [GO:0008284]; positive regulation of cytokinesis [GO:0032467]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0042787]; stem cell division [GO:0017145]; stress fiber assembly [GO:0043149]; trophectodermal cellular morphogenesis [GO:0001831]; Wnt signaling pathway [GO:0016055]	POZ domain binding [GO:0031208]	Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; polar microtubule [GO:0005827]	GO:0048208; GO:0031463; GO:0006888; GO:0000082; GO:0000139; GO:0031208; GO:0016055; GO:0007050; GO:0016477; GO:0005829; GO:0040016; GO:0070062; GO:0007369; GO:0007229; GO:0097193; GO:0016020; GO:0007080; GO:0035024; GO:0090090; GO:0008054; GO:0005654; GO:0005827; GO:0008284; GO:0032467; GO:0045842; GO:0043161; GO:0006513; GO:0000209; GO:0016567; GO:0042787; GO:0017145; GO:0043149; GO:0001831	SUBCELLULAR LOCATION: Nucleus. Golgi apparatus.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Disease mutation; ER-Golgi transport; Golgi apparatus; Isopeptide bond; Nucleus; Polymorphism; Reference proteome; Transport; Ubl conjugation; Ubl conjugation pathway	Alternative sequence (2); Beta strand (1); Chain (1); Cross-link (1); Erroneous initiation (1); Frameshift (2); Helix (22); Initiator methionine (1); Modified residue (1); Natural variant (5); Sequence conflict (5); Turn (5)
MA2B1_HUMAN	O00754	MA2B1_HUMAN	reviewed	Lysosomal alpha-mannosidase (Laman) (EC 3.2.1.24) (Lysosomal acid alpha-mannosidase) (Mannosidase alpha class 2B member 1) (Mannosidase alpha-B) [Cleaved into: Lysosomal alpha-mannosidase A peptide; Lysosomal alpha-mannosidase B peptide; Lysosomal alpha-mannosidase C peptide; Lysosomal alpha-mannosidase D peptide; Lysosomal alpha-mannosidase E peptide]	MAN2B1 LAMAN MANB	Homo sapiens (Human)	1011	extracellular exosome [GO:0070062]; lysosome [GO:0005764]; alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; zinc ion binding [GO:0008270]; cellular protein modification process [GO:0006464]; mannose metabolic process [GO:0006013]; protein deglycosylation [GO:0006517]	cellular protein modification process [GO:0006464]; mannose metabolic process [GO:0006013]; protein deglycosylation [GO:0006517]	alpha-mannosidase activity [GO:0004559]; carbohydrate binding [GO:0030246]; zinc ion binding [GO:0008270]	extracellular exosome [GO:0070062]; lysosome [GO:0005764]	GO:0004559; GO:0030246; GO:0006464; GO:0070062; GO:0005764; GO:0006013; GO:0006517; GO:0008270	SUBCELLULAR LOCATION: Lysosome.	Alternative splicing; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Glycosidase; Hydrolase; Lysosome; Metal-binding; Polymorphism; Reference proteome; Signal; Zinc; Zymogen	Active site (1); Alternative sequence (1); Chain (6); Disulfide bond (4); Erroneous initiation (2); Glycosylation (11); Metal binding (4); Natural variant (52); Sequence conflict (3); Signal peptide (1)
HPRT_HUMAN	P00492	HPRT_HUMAN	reviewed	Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase) (EC 2.4.2.8)	HPRT1 HPRT	Homo sapiens (Human)	218	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; guanine phosphoribosyltransferase activity [GO:0052657]; hypoxanthine phosphoribosyltransferase activity [GO:0004422]; magnesium ion binding [GO:0000287]; nucleotide binding [GO:0000166]; protein homodimerization activity [GO:0042803]; adenine salvage [GO:0006168]; central nervous system neuron development [GO:0021954]; cerebral cortex neuron differentiation [GO:0021895]; cytolysis [GO:0019835]; dendrite morphogenesis [GO:0048813]; dopamine metabolic process [GO:0042417]; GMP catabolic process [GO:0046038]; GMP salvage [GO:0032263]; grooming behavior [GO:0007625]; guanine salvage [GO:0006178]; hypoxanthine metabolic process [GO:0046100]; hypoxanthine salvage [GO:0043103]; IMP metabolic process [GO:0046040]; IMP salvage [GO:0032264]; locomotory behavior [GO:0007626]; lymphocyte proliferation [GO:0046651]; nucleobase-containing small molecule metabolic process [GO:0055086]; positive regulation of dopamine metabolic process [GO:0045964]; protein homotetramerization [GO:0051289]; purine nucleobase metabolic process [GO:0006144]; purine nucleotide biosynthetic process [GO:0006164]; purine ribonucleoside salvage [GO:0006166]; purine-containing compound salvage [GO:0043101]; response to amphetamine [GO:0001975]; small molecule metabolic process [GO:0044281]; striatum development [GO:0021756]	adenine salvage [GO:0006168]; central nervous system neuron development [GO:0021954]; cerebral cortex neuron differentiation [GO:0021895]; cytolysis [GO:0019835]; dendrite morphogenesis [GO:0048813]; dopamine metabolic process [GO:0042417]; GMP catabolic process [GO:0046038]; GMP salvage [GO:0032263]; grooming behavior [GO:0007625]; guanine salvage [GO:0006178]; hypoxanthine metabolic process [GO:0046100]; hypoxanthine salvage [GO:0043103]; IMP metabolic process [GO:0046040]; IMP salvage [GO:0032264]; locomotory behavior [GO:0007626]; lymphocyte proliferation [GO:0046651]; nucleobase-containing small molecule metabolic process [GO:0055086]; positive regulation of dopamine metabolic process [GO:0045964]; protein homotetramerization [GO:0051289]; purine-containing compound salvage [GO:0043101]; purine nucleobase metabolic process [GO:0006144]; purine nucleotide biosynthetic process [GO:0006164]; purine ribonucleoside salvage [GO:0006166]; response to amphetamine [GO:0001975]; small molecule metabolic process [GO:0044281]; striatum development [GO:0021756]	guanine phosphoribosyltransferase activity [GO:0052657]; hypoxanthine phosphoribosyltransferase activity [GO:0004422]; magnesium ion binding [GO:0000287]; nucleotide binding [GO:0000166]; protein homodimerization activity [GO:0042803]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0046038; GO:0032263; GO:0046040; GO:0032264; GO:0006168; GO:0021954; GO:0021895; GO:0019835; GO:0005737; GO:0005829; GO:0048813; GO:0042417; GO:0070062; GO:0007625; GO:0052657; GO:0006178; GO:0046100; GO:0004422; GO:0043103; GO:0007626; GO:0046651; GO:0000287; GO:0055086; GO:0000166; GO:0045964; GO:0042803; GO:0051289; GO:0006144; GO:0006164; GO:0006166; GO:0043101; GO:0001975; GO:0044281; GO:0021756	SUBCELLULAR LOCATION: Cytoplasm.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Glycosyltransferase; Gout; Magnesium; Metal-binding; Nucleotide-binding; Purine salvage; Reference proteome; Transferase	Active site (1); Beta strand (15); Binding site (3); Chain (1); Helix (9); Initiator methionine (1); Metal binding (1); Modified residue (2); Mutagenesis (1); Natural variant (73); Nucleotide binding (2); Turn (2)
TPC11_HUMAN	Q7Z392	TPC11_HUMAN	reviewed	Trafficking protein particle complex subunit 11	TRAPPC11 C4orf41	Homo sapiens (Human)	1133	Golgi apparatus [GO:0005794]; vesicle-mediated transport [GO:0016192]	vesicle-mediated transport [GO:0016192]		Golgi apparatus [GO:0005794]	GO:0005794; GO:0016192	SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network {ECO:0000250}.	Acetylation; Alternative splicing; Complete proteome; Disease mutation; ER-Golgi transport; Golgi apparatus; Limb-girdle muscular dystrophy; Reference proteome; Transport	Alternative sequence (5); Chain (1); Erroneous initiation (6); Erroneous termination (1); Modified residue (1); Natural variant (1); Sequence conflict (19)
ACBP_HUMAN	P07108	ACBP_HUMAN	reviewed	Acyl-CoA-binding protein (ACBP) (Diazepam-binding inhibitor) (DBI) (Endozepine) (EP)	DBI	Homo sapiens (Human)	87	endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; perinuclear endoplasmic reticulum [GO:0097038]; benzodiazepine receptor binding [GO:0030156]; lipid binding [GO:0008289]; long-chain fatty acyl-CoA binding [GO:0036042]; protein dimerization activity [GO:0046983]; behavioral fear response [GO:0001662]; hair follicle development [GO:0001942]; lateral ventricle development [GO:0021670]; learning or memory [GO:0007611]; long-term synaptic potentiation [GO:0060291]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; transport [GO:0006810]; triglyceride metabolic process [GO:0006641]	behavioral fear response [GO:0001662]; hair follicle development [GO:0001942]; lateral ventricle development [GO:0021670]; learning or memory [GO:0007611]; long-term synaptic potentiation [GO:0060291]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; transport [GO:0006810]; triglyceride metabolic process [GO:0006641]	benzodiazepine receptor binding [GO:0030156]; lipid binding [GO:0008289]; long-chain fatty acyl-CoA binding [GO:0036042]; protein dimerization activity [GO:0046983]	endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; perinuclear endoplasmic reticulum [GO:0097038]	GO:0005794; GO:0001662; GO:0030156; GO:0005783; GO:0070062; GO:0001942; GO:0021670; GO:0007611; GO:0008289; GO:0036042; GO:0060291; GO:0005739; GO:0097038; GO:0036151; GO:0046983; GO:0006810; GO:0006641	SUBCELLULAR LOCATION: Endoplasmic reticulum. Golgi apparatus. Note=Golgi localization is dependent on ligand binding.	3D-structure; Acetylation; Alternative promoter usage; Alternative splicing; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Golgi apparatus; Lipid-binding; Phosphoprotein; Polymorphism; Reference proteome; Transport	Alternative sequence (5); Binding site (3); Chain (1); Domain (1); Helix (5); Initiator methionine (1); Modified residue (11); Natural variant (3); Region (1); Turn (1)
ADRM1_HUMAN	Q16186	ADRM1_HUMAN	reviewed	Proteasomal ubiquitin receptor ADRM1 (110 kDa cell membrane glycoprotein) (Gp110) (Adhesion-regulating molecule 1) (ARM-1) (Proteasome regulatory particle non-ATPase 13) (hRpn13) (Rpn13 homolog)	ADRM1 GP110	Homo sapiens (Human)	407	cytoplasm [GO:0005737]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; proteasome complex [GO:0000502]; endopeptidase activator activity [GO:0061133]; protease binding [GO:0002020]; proteasome binding [GO:0070628]; positive regulation of endopeptidase activity [GO:0010950]; proteasome assembly [GO:0043248]; transcription elongation from RNA polymerase II promoter [GO:0006368]	positive regulation of endopeptidase activity [GO:0010950]; proteasome assembly [GO:0043248]; transcription elongation from RNA polymerase II promoter [GO:0006368]	endopeptidase activator activity [GO:0061133]; protease binding [GO:0002020]; proteasome binding [GO:0070628]	cytoplasm [GO:0005737]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; proteasome complex [GO:0000502]	GO:0005737; GO:0061133; GO:0005887; GO:0016020; GO:0005654; GO:0005886; GO:0010950; GO:0002020; GO:0043248; GO:0070628; GO:0000502; GO:0006368	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Isopeptide bond; Nucleus; Phosphoprotein; Proteasome; Reference proteome; Ubl conjugation	Beta strand (15); Chain (1); Compositional bias (3); Cross-link (1); Domain (1); Helix (14); Initiator methionine (1); Modified residue (5); Region (2); Sequence conflict (1); Turn (4)
H3BNU9_HUMAN	H3BNU9	H3BNU9_HUMAN	unreviewed	Calcium-regulated heat stable protein 1 (Fragment)	CARHSP1	Homo sapiens (Human)	131	DNA binding [GO:0003677]; regulation of transcription, DNA-templated [GO:0006355]	regulation of transcription, DNA-templated [GO:0006355]	DNA binding [GO:0003677]		GO:0003677; GO:0006355		Complete proteome; Proteomics identification; Reference proteome	Non-terminal residue (1)
MET10_HUMAN	Q5JPI9	MET10_HUMAN	reviewed	Protein-lysine N-methyltransferase METTL10 (EC 2.1.1.-) (Methyltransferase-like protein 10)	METTL10 C10orf138	Homo sapiens (Human)	291	cytoplasm [GO:0005737]; methyltransferase activity [GO:0008168]		methyltransferase activity [GO:0008168]	cytoplasm [GO:0005737]	GO:0005737; GO:0008168	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03188}.	Acetylation; Complete proteome; Cytoplasm; Methyltransferase; Phosphoprotein; Polymorphism; Reference proteome; S-adenosyl-L-methionine; Transferase	Chain (1); Initiator methionine (1); Modified residue (2); Natural variant (1); Sequence conflict (2)
G3V238_HUMAN	G3V238	G3V238_HUMAN	unreviewed	Protein-lysine N-methyltransferase METTL10	METTL10	Homo sapiens (Human)	104	methyltransferase activity [GO:0008168]		methyltransferase activity [GO:0008168]		GO:0008168		Complete proteome; Proteomics identification; Reference proteome	
CNBP_HUMAN	P62633	CNBP_HUMAN	reviewed	Cellular nucleic acid-binding protein (CNBP) (Zinc finger protein 9)	CNBP RNF163 ZNF9	Homo sapiens (Human)	177	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; poly(A) RNA binding [GO:0044822]; sequence-specific DNA binding transcription factor activity [GO:0003700]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270]; cholesterol biosynthetic process [GO:0006695]; positive regulation of cell proliferation [GO:0008284]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]	cholesterol biosynthetic process [GO:0006695]; positive regulation of cell proliferation [GO:0008284]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]	poly(A) RNA binding [GO:0044822]; sequence-specific DNA binding transcription factor activity [GO:0003700]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270]	cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]	GO:0006695; GO:0005829; GO:0005783; GO:0005634; GO:0044822; GO:0008284; GO:0045944; GO:0045893; GO:0006355; GO:0003700; GO:0003697; GO:0003727; GO:0006351; GO:0008270	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.	Acetylation; Alternative splicing; Complete proteome; Cytoplasm; DNA-binding; Endoplasmic reticulum; Metal-binding; Methylation; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger	Alternative sequence (5); Chain (1); Compositional bias (1); Initiator methionine (1); Modified residue (4); Mutagenesis (2); Sequence conflict (1); Zinc finger (7)
4EBP2_HUMAN	Q13542	4EBP2_HUMAN	reviewed	Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2)	EIF4EBP2	Homo sapiens (Human)	120	intracellular [GO:0005622]; eukaryotic initiation factor 4E binding [GO:0008190]; translation repressor activity [GO:0030371]; cAMP-mediated signaling [GO:0019933]; insulin receptor signaling pathway [GO:0008286]; memory [GO:0007613]; negative regulation of translational initiation [GO:0045947]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic transmission [GO:0050804]; social behavior [GO:0035176]; TOR signaling [GO:0031929]; translation [GO:0006412]	cAMP-mediated signaling [GO:0019933]; insulin receptor signaling pathway [GO:0008286]; memory [GO:0007613]; negative regulation of translational initiation [GO:0045947]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic transmission [GO:0050804]; social behavior [GO:0035176]; TOR signaling [GO:0031929]; translation [GO:0006412]	eukaryotic initiation factor 4E binding [GO:0008190]; translation repressor activity [GO:0030371]	intracellular [GO:0005622]	GO:0031929; GO:0019933; GO:0008190; GO:0008286; GO:0005622; GO:0007613; GO:0045947; GO:0048167; GO:0050804; GO:0035176; GO:0006412; GO:0030371		3D-structure; Complete proteome; Phosphoprotein; Protein synthesis inhibitor; Reference proteome; Translation regulation	Beta strand (2); Chain (1); Helix (1); Modified residue (7); Motif (3); Mutagenesis (6); Turn (1)
G3V4E5_HUMAN	G3V4E5	G3V4E5_HUMAN	unreviewed	Disks large-associated protein 5 (Fragment)	DLGAP5	Homo sapiens (Human)	234	cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815]			cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815]	GO:0005737; GO:0005815		Complete proteome; Proteomics identification; Reference proteome	Non-terminal residue (1)
E9PF46_HUMAN	E9PF46	E9PF46_HUMAN	unreviewed	Acylphosphatase (EC 3.6.1.7)	ACYP2	Homo sapiens (Human)	97	acylphosphatase activity [GO:0003998]		acylphosphatase activity [GO:0003998]		GO:0003998		Complete proteome; Hydrolase; Proteomics identification; Reference proteome	
F8WA34_HUMAN	F8WA34	F8WA34_HUMAN	unreviewed	Acylphosphatase (EC 3.6.1.7)	ACYP2	Homo sapiens (Human)	98	acylphosphatase activity [GO:0003998]		acylphosphatase activity [GO:0003998]		GO:0003998		Complete proteome; Hydrolase; Proteomics identification; Reference proteome	
RAB6A_HUMAN	P20340	RAB6A_HUMAN	reviewed	Ras-related protein Rab-6A (Rab-6)	RAB6A RAB6	Homo sapiens (Human)	208	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; trans-Golgi network [GO:0005802]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]; protein domain specific binding [GO:0019904]; antigen processing and presentation [GO:0019882]; early endosome to Golgi transport [GO:0034498]; minus-end-directed organelle transport along microtubule [GO:0072385]; peptidyl-cysteine methylation [GO:0018125]; protein localization to Golgi apparatus [GO:0034067]; protein targeting to Golgi [GO:0000042]; Rab protein signal transduction [GO:0032482]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]; viral process [GO:0016032]	antigen processing and presentation [GO:0019882]; early endosome to Golgi transport [GO:0034498]; minus-end-directed organelle transport along microtubule [GO:0072385]; peptidyl-cysteine methylation [GO:0018125]; protein localization to Golgi apparatus [GO:0034067]; protein targeting to Golgi [GO:0000042]; Rab protein signal transduction [GO:0032482]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]; viral process [GO:0016032]	GTPase activity [GO:0003924]; GTP binding [GO:0005525]; myosin V binding [GO:0031489]; protein domain specific binding [GO:0019904]	cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; trans-Golgi network [GO:0005802]	GO:0005525; GO:0003924; GO:0005794; GO:0000139; GO:0032482; GO:0019882; GO:0031410; GO:0005829; GO:0034498; GO:0070062; GO:0016020; GO:0072385; GO:0031489; GO:0018125; GO:0019904; GO:0034067; GO:0000042; GO:0006890; GO:0005802; GO:0016032	SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:23091056}. Golgi apparatus membrane; Lipid-anchor.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; ER-Golgi transport; GTP-binding; Golgi apparatus; Host-virus interaction; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Phosphoprotein; Prenylation; Protein transport; Reference proteome; Transport	Alternative sequence (3); Beta strand (6); Chain (1); Helix (9); Initiator methionine (1); Lipidation (2); Modified residue (3); Motif (1); Mutagenesis (3); Nucleotide binding (4); Sequence conflict (1); Turn (1)
F5GX61_HUMAN	F5GX61	F5GX61_HUMAN	unreviewed	Ras-related protein Rab-6A	RAB6A	Homo sapiens (Human)	87	intracellular [GO:0005622]; GTP binding [GO:0005525]; Rab protein signal transduction [GO:0032482]	Rab protein signal transduction [GO:0032482]	GTP binding [GO:0005525]	intracellular [GO:0005622]	GO:0005525; GO:0032482; GO:0005622		Complete proteome; GTP-binding; Nucleotide-binding; Proteomics identification; Reference proteome	
E9PBE3_HUMAN	E9PBE3	E9PBE3_HUMAN	unreviewed	Uncharacterized protein		Homo sapiens (Human)	544	BBSome [GO:0034464]			BBSome [GO:0034464]	GO:0034464		Complete proteome; Reference proteome	
Q5QPN5_HUMAN	Q5QPN5	Q5QPN5_HUMAN	unreviewed	Acyl-protein thioesterase 2 (Fragment)	LYPLA2	Homo sapiens (Human)	91	hydrolase activity [GO:0016787]		hydrolase activity [GO:0016787]		GO:0016787		Complete proteome; Proteomics identification; Reference proteome	Non-terminal residue (1)
LYPA2_HUMAN	O95372	LYPA2_HUMAN	reviewed	Acyl-protein thioesterase 2 (APT-2) (EC 3.1.2.-) (Lysophospholipase II) (LPL-II) (LysoPLA II)	LYPLA2 APT2	Homo sapiens (Human)	231	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; hydrolase activity [GO:0016787]; fatty acid metabolic process [GO:0006631]	fatty acid metabolic process [GO:0006631]	hydrolase activity [GO:0016787]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]	GO:0005737; GO:0070062; GO:0006631; GO:0016787	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.	Complete proteome; Cytoplasm; Fatty acid metabolism; Hydrolase; Lipid metabolism; Reference proteome	Active site (3); Chain (1); Frameshift (1)
CENPF_HUMAN	P49454	CENPF_HUMAN	reviewed	Centromere protein F (CENP-F) (AH antigen) (Kinetochore protein CENPF) (Mitosin)	CENPF	Homo sapiens (Human)	3210	chromosome, centromeric region [GO:0000775]; condensed chromosome outer kinetochore [GO:0000940]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; midbody [GO:0030496]; nuclear envelope [GO:0005635]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; pronucleus [GO:0045120]; spindle [GO:0005819]; spindle pole [GO:0000922]; chromatin binding [GO:0003682]; dynein binding [GO:0045502]; protein C-terminus binding [GO:0008022]; protein homodimerization activity [GO:0042803]; transcription factor binding [GO:0008134]; cell differentiation [GO:0030154]; cell division [GO:0051301]; cell proliferation [GO:0008283]; chromosome segregation [GO:0007059]; DNA biosynthetic process [GO:0071897]; G2/M transition of mitotic cell cycle [GO:0000086]; kinetochore assembly [GO:0051382]; metaphase plate congression [GO:0051310]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; mitotic spindle assembly checkpoint [GO:0007094]; muscle organ development [GO:0007517]; negative regulation of transcription, DNA-templated [GO:0045892]; protein transport [GO:0015031]; regulation of cell cycle [GO:0051726]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of striated muscle tissue development [GO:0016202]; response to drug [GO:0042493]; small GTPase mediated signal transduction [GO:0007264]	cell differentiation [GO:0030154]; cell division [GO:0051301]; cell proliferation [GO:0008283]; chromosome segregation [GO:0007059]; DNA biosynthetic process [GO:0071897]; G2/M transition of mitotic cell cycle [GO:0000086]; kinetochore assembly [GO:0051382]; metaphase plate congression [GO:0051310]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; mitotic spindle assembly checkpoint [GO:0007094]; muscle organ development [GO:0007517]; negative regulation of transcription, DNA-templated [GO:0045892]; protein transport [GO:0015031]; regulation of cell cycle [GO:0051726]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of striated muscle tissue development [GO:0016202]; response to drug [GO:0042493]; small GTPase mediated signal transduction [GO:0007264]	chromatin binding [GO:0003682]; dynein binding [GO:0045502]; protein C-terminus binding [GO:0008022]; protein homodimerization activity [GO:0042803]; transcription factor binding [GO:0008134]	chromosome, centromeric region [GO:0000775]; condensed chromosome outer kinetochore [GO:0000940]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; kinetochore [GO:0000776]; midbody [GO:0030496]; nuclear envelope [GO:0005635]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; pronucleus [GO:0045120]; spindle [GO:0005819]; spindle pole [GO:0000922]	GO:0071897; GO:0000086; GO:0030154; GO:0051301; GO:0008283; GO:0003682; GO:0007059; GO:0000775; GO:0000940; GO:0005737; GO:0005829; GO:0045502; GO:0000776; GO:0051382; GO:0051310; GO:0030496; GO:0000278; GO:0007067; GO:0007094; GO:0007517; GO:0045892; GO:0005635; GO:0016363; GO:0005654; GO:0005634; GO:0048471; GO:0045120; GO:0008022; GO:0042803; GO:0015031; GO:0010389; GO:0051726; GO:0016202; GO:0042493; GO:0007264; GO:0005819; GO:0000922; GO:0008134	SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Nucleus matrix. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Relocalizes to the kinetochore/centromere (coronal surface of the outer plate) and the spindle during mitosis. Observed in nucleus during interphase but not in the nucleolus. At metaphase becomes localized to areas including kinetochore and mitotic apparatus as well as cytoplasm. By telophase, is concentrated within the intracellular bridge at either side of the mid-body.	Acetylation; Cell cycle; Cell division; Centromere; Chromosome; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; DNA synthesis; Developmental protein; Differentiation; Kinetochore; Lipoprotein; Methylation; Mitosis; Myogenesis; Nucleus; Phosphoprotein; Polymorphism; Prenylation; Reference proteome; Repeat	Chain (1); Coiled coil (5); Lipidation (1); Modified residue (33); Motif (1); Natural variant (17); Propeptide (1); Region (7); Repeat (4); Sequence conflict (15)
ULA1_HUMAN	Q13564	ULA1_HUMAN	reviewed	NEDD8-activating enzyme E1 regulatory subunit (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1) (Amyloid protein-binding protein 1) (Proto-oncogene protein 1)	NAE1 APPBP1 HPP1	Homo sapiens (Human)	534	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; NEDD8 activating enzyme activity [GO:0019781]; protein heterodimerization activity [GO:0046982]; ubiquitin protein ligase binding [GO:0031625]; mitotic DNA replication checkpoint [GO:0033314]; neuron apoptotic process [GO:0051402]; protein neddylation [GO:0045116]; regulation of apoptotic process [GO:0042981]; regulation of neuron apoptotic process [GO:0043523]; signal transduction [GO:0007165]	mitotic DNA replication checkpoint [GO:0033314]; neuron apoptotic process [GO:0051402]; protein neddylation [GO:0045116]; regulation of apoptotic process [GO:0042981]; regulation of neuron apoptotic process [GO:0043523]; signal transduction [GO:0007165]	NEDD8 activating enzyme activity [GO:0019781]; protein heterodimerization activity [GO:0046982]; ubiquitin protein ligase binding [GO:0031625]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]	GO:0019781; GO:0005737; GO:0005829; GO:0033314; GO:0051402; GO:0005634; GO:0005886; GO:0046982; GO:0045116; GO:0042981; GO:0043523; GO:0007165; GO:0031625	SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14557245}. Note=Colocalizes with APP in lipid rafts.	3D-structure; Acetylation; Alternative splicing; Apoptosis; Cell cycle; Cell membrane; Complete proteome; Membrane; Polymorphism; Reference proteome; Ubl conjugation; Ubl conjugation pathway	Alternative sequence (3); Beta strand (15); Chain (1); Helix (26); Initiator methionine (1); Modified residue (3); Mutagenesis (1); Natural variant (1); Region (1); Sequence conflict (2); Site (1); Turn (8)
UN45A_HUMAN	Q9H3U1	UN45A_HUMAN	reviewed	Protein unc-45 homolog A (Unc-45A) (GCUNC-45) (Smooth muscle cell-associated protein 1) (SMAP-1)	UNC45A SMAP1	Homo sapiens (Human)	944	cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; cell differentiation [GO:0030154]; chaperone-mediated protein folding [GO:0061077]; muscle organ development [GO:0007517]	cell differentiation [GO:0030154]; chaperone-mediated protein folding [GO:0061077]; muscle organ development [GO:0007517]		cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]	GO:0005794; GO:0030154; GO:0061077; GO:0005737; GO:0007517; GO:0005654; GO:0048471	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16478993}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16478993}. Nucleus {ECO:0000269|PubMed:16478993}. Note=Predominant in the perinuclear region. Little protein in the nucleus.	3D-structure; Acetylation; Alternative splicing; Chaperone; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Myogenesis; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; TPR repeat	Alternative sequence (2); Chain (1); Helix (7); Modified residue (3); Mutagenesis (4); Natural variant (1); Repeat (3); Sequence conflict (1); Turn (1)
RS4X_HUMAN	P62701	RS4X_HUMAN	reviewed	40S ribosomal protein S4, X isoform (SCR10) (Single copy abundant mRNA protein)	RPS4X CCG2 RPS4 SCAR	Homo sapiens (Human)	263	cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; polysome [GO:0005844]; ribonucleoprotein complex [GO:0030529]; ribosome [GO:0005840]; small ribosomal subunit [GO:0015935]; poly(A) RNA binding [GO:0044822]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; multicellular organismal development [GO:0007275]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of cell proliferation [GO:0008284]; positive regulation of translation [GO:0045727]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; multicellular organismal development [GO:0007275]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of cell proliferation [GO:0008284]; positive regulation of translation [GO:0045727]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	poly(A) RNA binding [GO:0044822]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]	cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; polysome [GO:0005844]; ribonucleoprotein complex [GO:0030529]; ribosome [GO:0005840]; small ribosomal subunit [GO:0015935]	GO:0006614; GO:0044267; GO:0036464; GO:0005829; GO:0022627; GO:0070062; GO:0005925; GO:0010467; GO:0016020; GO:0007275; GO:0000184; GO:0044822; GO:0005844; GO:0008284; GO:0045727; GO:0019843; GO:0030529; GO:0005840; GO:0015935; GO:0003735; GO:0006412; GO:0006414; GO:0006413; GO:0006415; GO:0019058; GO:0016032; GO:0019083	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.	3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; RNA-binding; Reference proteome; Ribonucleoprotein; Ribosomal protein; rRNA-binding	Chain (1); Domain (1); Initiator methionine (1); Sequence conflict (2)
B1ALK7_HUMAN	B1ALK7	B1ALK7_HUMAN	unreviewed	Rho guanine nucleotide exchange factor 7	ARHGEF7	Homo sapiens (Human)	705	intracellular [GO:0005622]; Rho guanyl-nucleotide exchange factor activity [GO:0005089]; intracellular signal transduction [GO:0035556]	intracellular signal transduction [GO:0035556]	Rho guanyl-nucleotide exchange factor activity [GO:0005089]	intracellular [GO:0005622]	GO:0005089; GO:0005622; GO:0035556		Complete proteome; Guanine-nucleotide releasing factor; Proteomics identification; Reference proteome	
ARHG7_HUMAN	Q14155	ARHG7_HUMAN	reviewed	Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85)	ARHGEF7 COOL1 KIAA0142 P85SPR PAK3BP PIXB Nbla10314	Homo sapiens (Human)	803	cell cortex [GO:0005938]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; protein complex [GO:0043234]; ruffle [GO:0001726]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein kinase binding [GO:0019901]; Rho guanyl-nucleotide exchange factor activity [GO:0005089]; apoptotic signaling pathway [GO:0097190]; axon guidance [GO:0007411]; ephrin receptor signaling pathway [GO:0048013]; epidermal growth factor receptor signaling pathway [GO:0007173]; focal adhesion assembly [GO:0048041]; hematopoietic progenitor cell differentiation [GO:0002244]; lamellipodium assembly [GO:0030032]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; neurotrophin TRK receptor signaling pathway [GO:0048011]; positive regulation of apoptotic process [GO:0043065]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of GTPase activity [GO:0043547]; positive regulation of lamellipodium morphogenesis [GO:2000394]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]	apoptotic signaling pathway [GO:0097190]; axon guidance [GO:0007411]; ephrin receptor signaling pathway [GO:0048013]; epidermal growth factor receptor signaling pathway [GO:0007173]; focal adhesion assembly [GO:0048041]; hematopoietic progenitor cell differentiation [GO:0002244]; lamellipodium assembly [GO:0030032]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; neurotrophin TRK receptor signaling pathway [GO:0048011]; positive regulation of apoptotic process [GO:0043065]; positive regulation of fibroblast migration [GO:0010763]; positive regulation of GTPase activity [GO:0043547]; positive regulation of lamellipodium morphogenesis [GO:2000394]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]	guanyl-nucleotide exchange factor activity [GO:0005085]; protein kinase binding [GO:0019901]; Rho guanyl-nucleotide exchange factor activity [GO:0005089]	cell cortex [GO:0005938]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; neuronal cell body [GO:0043025]; neuron projection [GO:0043005]; protein complex [GO:0043234]; ruffle [GO:0001726]	GO:0005089; GO:0097190; GO:0007411; GO:0005938; GO:0005829; GO:0048013; GO:0007173; GO:0005925; GO:0048041; GO:0005085; GO:0002244; GO:0030027; GO:0030032; GO:0042059; GO:0043005; GO:0043025; GO:0048011; GO:0043547; GO:0043065; GO:0010763; GO:2000394; GO:1900026; GO:0043234; GO:0019901; GO:0051056; GO:0001726; GO:0007165; GO:0007264	SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Note=Detected at cell adhesions. A small proportion is detected at focal adhesions.	3D-structure; Acetylation; Alternative splicing; Cell junction; Cell projection; Complete proteome; Cytoplasm; Guanine-nucleotide releasing factor; Neurogenesis; Phosphoprotein; Polymorphism; Reference proteome; SH3 domain	Alternative sequence (5); Beta strand (6); Chain (1); Domain (4); Erroneous initiation (3); Helix (15); Modified residue (4); Natural variant (1); Sequence conflict (6); Turn (6)
F5H3P3_HUMAN	F5H3P3	F5H3P3_HUMAN	unreviewed	Rho GDP-dissociation inhibitor 2 (Fragment)	ARHGDIB	Homo sapiens (Human)	159	cytoplasm [GO:0005737]; Rho GDP-dissociation inhibitor activity [GO:0005094]		Rho GDP-dissociation inhibitor activity [GO:0005094]	cytoplasm [GO:0005737]	GO:0005094; GO:0005737		Complete proteome; Proteomics identification; Reference proteome	Non-terminal residue (1)
RL8_HUMAN	P62917	RL8_HUMAN	reviewed	60S ribosomal protein L8	RPL8	Homo sapiens (Human)	257	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]	GO:0003723; GO:0006614; GO:0044267; GO:0005737; GO:0005829; GO:0022625; GO:0005925; GO:0010467; GO:0016020; GO:0000184; GO:0005730; GO:0044822; GO:0019843; GO:0003735; GO:0006412; GO:0006414; GO:0006413; GO:0006415; GO:0019058; GO:0016032; GO:0019083	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000303|PubMed:12962325}.	3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Hydroxylation; Polymorphism; RNA-binding; Reference proteome; Ribonucleoprotein; Ribosomal protein; rRNA-binding	Chain (1); Initiator methionine (1); Modified residue (1); Mutagenesis (1); Natural variant (1)
UB2G1_HUMAN	P62253	UB2G1_HUMAN	reviewed	Ubiquitin-conjugating enzyme E2 G1 (EC 6.3.2.19) (E217K) (UBC7) (Ubiquitin carrier protein G1) (Ubiquitin-protein ligase G1) [Cleaved into: Ubiquitin-conjugating enzyme E2 G1, N-terminally processed]	UBE2G1 UBE2G	Homo sapiens (Human)	170	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; ATP binding [GO:0005524]; ligase activity [GO:0016874]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; cellular protein catabolic process [GO:0044257]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; ubiquitin-dependent protein catabolic process [GO:0006511]	cellular protein catabolic process [GO:0044257]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; ubiquitin-dependent protein catabolic process [GO:0006511]	ATP binding [GO:0005524]; ligase activity [GO:0016874]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]	cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]	GO:0005524; GO:0044257; GO:0005737; GO:0070062; GO:0016874; GO:0070936; GO:0070534; GO:0061631; GO:0061630; GO:0031625; GO:0006511; GO:0004842		3D-structure; ATP-binding; Acetylation; Complete proteome; Direct protein sequencing; Ligase; Nucleotide-binding; Reference proteome; Ubl conjugation pathway	Active site (1); Beta strand (4); Chain (2); Erroneous initiation (1); Helix (3); Initiator methionine (1); Modified residue (2); Turn (2)
NR2CA_HUMAN	Q86WQ0	NR2CA_HUMAN	reviewed	Nuclear receptor 2C2-associated protein (TR4 orphan receptor-associated 16 kDa protein)	NR2C2AP TRA16	Homo sapiens (Human)	139	extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; gene expression [GO:0010467]; transcription initiation from RNA polymerase II promoter [GO:0006367]	gene expression [GO:0010467]; transcription initiation from RNA polymerase II promoter [GO:0006367]		extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]	GO:0070062; GO:0010467; GO:0005654; GO:0006367	SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12486131}.	Alternative splicing; Complete proteome; Nucleus; Reference proteome	Alternative sequence (1); Chain (1)
IF2P_HUMAN	O60841	IF2P_HUMAN	reviewed	Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2)	EIF5B IF2 KIAA0741	Homo sapiens (Human)	1220	cytoplasm [GO:0005737]; cytosol [GO:0005829]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; poly(A) RNA binding [GO:0044822]; translation initiation factor activity [GO:0003743]; cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; regulation of translational initiation [GO:0006446]; translation [GO:0006412]; translational initiation [GO:0006413]	cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; regulation of translational initiation [GO:0006446]; translation [GO:0006412]; translational initiation [GO:0006413]	GTPase activity [GO:0003924]; GTP binding [GO:0005525]; poly(A) RNA binding [GO:0044822]; translation initiation factor activity [GO:0003743]	cytoplasm [GO:0005737]; cytosol [GO:0005829]	GO:0005525; GO:0003924; GO:0044267; GO:0005737; GO:0005829; GO:0010467; GO:0044822; GO:0006446; GO:0006412; GO:0003743; GO:0006413	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.	Complete proteome; Cytoplasm; Direct protein sequencing; GTP-binding; Initiation factor; Nucleotide-binding; Phosphoprotein; Polymorphism; Protein biosynthesis; Reference proteome	Chain (1); Compositional bias (8); Domain (1); Erroneous initiation (1); Modified residue (20); Mutagenesis (4); Natural variant (3); Nucleotide binding (1); Region (5); Sequence conflict (7)
Z780A_HUMAN	O75290	Z780A_HUMAN	reviewed	Zinc finger protein 780A	ZNF780A	Homo sapiens (Human)	641	nucleus [GO:0005634]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; sequence-specific DNA binding transcription factor activity [GO:0003700]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]	regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]	DNA binding [GO:0003677]; metal ion binding [GO:0046872]; sequence-specific DNA binding transcription factor activity [GO:0003700]	nucleus [GO:0005634]	GO:0003677; GO:0046872; GO:0005634; GO:0006355; GO:0003700; GO:0006351	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.	Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger	Alternative sequence (4); Chain (1); Domain (1); Erroneous gene model prediction (1); Sequence conflict (1); Zinc finger (17)
TAGL2_HUMAN	P37802	TAGL2_HUMAN	reviewed	Transgelin-2 (Epididymis tissue protein Li 7e) (SM22-alpha homolog)	TAGLN2 KIAA0120 CDABP0035	Homo sapiens (Human)	199	extracellular exosome [GO:0070062]; vesicle [GO:0031982]; epithelial cell differentiation [GO:0030855]	epithelial cell differentiation [GO:0030855]		extracellular exosome [GO:0070062]; vesicle [GO:0031982]	GO:0030855; GO:0070062; GO:0031982		3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Phosphoprotein; Polymorphism; Reference proteome	Alternative sequence (1); Beta strand (3); Chain (1); Domain (1); Erroneous initiation (2); Helix (6); Initiator methionine (1); Modified residue (4); Natural variant (1); Repeat (1); Turn (2)
XPO1_HUMAN	O14980	XPO1_HUMAN	reviewed	Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog)	XPO1 CRM1	Homo sapiens (Human)	1071	annulate lamellae [GO:0005642]; Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]; nucleocytoplasmic transporter activity [GO:0005487]; protein transporter activity [GO:0008565]; RNA binding [GO:0003723]; transporter activity [GO:0005215]; gene expression [GO:0010467]; intracellular transport of virus [GO:0075733]; mitotic cell cycle [GO:0000278]; mRNA transport [GO:0051028]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; protein export from nucleus [GO:0006611]; protein localization to nucleus [GO:0034504]; regulation of centrosome duplication [GO:0010824]; regulation of protein catabolic process [GO:0042176]; regulation of protein export from nucleus [GO:0046825]; response to drug [GO:0042493]; ribosomal large subunit export from nucleus [GO:0000055]; ribosomal small subunit export from nucleus [GO:0000056]; small GTPase mediated signal transduction [GO:0007264]; transforming growth factor beta receptor signaling pathway [GO:0007179]; viral life cycle [GO:0019058]; viral process [GO:0016032]	gene expression [GO:0010467]; intracellular transport of virus [GO:0075733]; mitotic cell cycle [GO:0000278]; mRNA transport [GO:0051028]; negative regulation of transcription from RNA polymerase II promoter [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; protein export from nucleus [GO:0006611]; protein localization to nucleus [GO:0034504]; regulation of centrosome duplication [GO:0010824]; regulation of protein catabolic process [GO:0042176]; regulation of protein export from nucleus [GO:0046825]; response to drug [GO:0042493]; ribosomal large subunit export from nucleus [GO:0000055]; ribosomal small subunit export from nucleus [GO:0000056]; small GTPase mediated signal transduction [GO:0007264]; transforming growth factor beta receptor signaling pathway [GO:0007179]; viral life cycle [GO:0019058]; viral process [GO:0016032]	nucleocytoplasmic transporter activity [GO:0005487]; protein transporter activity [GO:0008565]; RNA binding [GO:0003723]; transporter activity [GO:0005215]	annulate lamellae [GO:0005642]; Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]	GO:0015030; GO:0003723; GO:0005642; GO:0005737; GO:0005829; GO:0010467; GO:0043231; GO:0075733; GO:0000776; GO:0051028; GO:0016020; GO:0000278; GO:0000122; GO:0030512; GO:0005635; GO:0031965; GO:0005487; GO:0005730; GO:0005654; GO:0005634; GO:0006611; GO:0034504; GO:0008565; GO:0010824; GO:0042176; GO:0046825; GO:0042493; GO:0030529; GO:0000055; GO:0000056; GO:0007264; GO:0007179; GO:0005215; GO:0019058; GO:0016032	SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleoplasm. Nucleus, Cajal body. Nucleus, nucleolus. Note=Located in the nucleoplasm, Cajal bodies and nucleoli. Shuttles between the nucleus/nucleolus and the cytoplasm.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Host-virus interaction; Nucleus; Phosphoprotein; Protein transport; RNA-binding; Reference proteome; Repeat; Transport; mRNA transport	Beta strand (6); Chain (1); Domain (1); Helix (57); Modified residue (6); Mutagenesis (25); Region (5); Repeat (10); Sequence conflict (3); Turn (8)
PRS4_HUMAN	P62191	PRS4_HUMAN	reviewed	26S protease regulatory subunit 4 (P26s4) (26S proteasome AAA-ATPase subunit RPT2) (Proteasome 26S subunit ATPase 1)	PSMC1	Homo sapiens (Human)	440	cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic proteasome complex [GO:0031597]; membrane [GO:0016020]; nuclear proteasome complex [GO:0031595]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; poly(A) RNA binding [GO:0044822]; proteasome-activating ATPase activity [GO:0036402]; TBP-class protein binding [GO:0017025]; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [GO:0045899]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031145]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; apoptotic process [GO:0006915]; cellular nitrogen compound metabolic process [GO:0034641]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; ER-associated ubiquitin-dependent protein catabolic process [GO:0030433]; G1/S transition of mitotic cell cycle [GO:0000082]; gene expression [GO:0010467]; innate immune response [GO:0045087]; mitotic cell cycle [GO:0000278]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051436]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of proteasomal protein catabolic process [GO:1901800]; positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [GO:0045899]; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition [GO:0051437]; programmed cell death [GO:0012501]; protein polyubiquitination [GO:0000209]; regulation of apoptotic process [GO:0042981]; regulation of cellular amino acid metabolic process [GO:0006521]; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [GO:0051439]; small molecule metabolic process [GO:0044281]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; viral process [GO:0016032]	ATPase activity [GO:0016887]; ATP binding [GO:0005524]; poly(A) RNA binding [GO:0044822]; proteasome-activating ATPase activity [GO:0036402]; TBP-class protein binding [GO:0017025]	cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic proteasome complex [GO:0031597]; membrane [GO:0016020]; nuclear proteasome complex [GO:0031595]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]	GO:0005524; GO:0016887; GO:0006977; GO:0030433; GO:0000082; GO:0017025; GO:0031145; GO:0042590; GO:0002479; GO:0002474; GO:0006915; GO:0030054; GO:0034641; GO:0005737; GO:0005829; GO:0031597; GO:0010467; GO:0045087; GO:0016020; GO:0000278; GO:0043066; GO:0090090; GO:0051436; GO:0031595; GO:0005654; GO:0005634; GO:0044822; GO:0045899; GO:0090263; GO:1901800; GO:0051437; GO:0012501; GO:0022624; GO:0000502; GO:0008540; GO:0036402; GO:0000209; GO:0042981; GO:0006521; GO:0051439; GO:0044281; GO:0002223; GO:0016032	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.	ATP-binding; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Isopeptide bond; Lipoprotein; Myristate; Nucleotide-binding; Nucleus; Phosphoprotein; Proteasome; Reference proteome; Ubl conjugation	Alternative sequence (1); Chain (1); Cross-link (1); Initiator methionine (1); Lipidation (1); Modified residue (4); Nucleotide binding (1); Sequence conflict (3)
LTOR4_HUMAN	Q0VGL1	LTOR4_HUMAN	reviewed	Ragulator complex protein LAMTOR4 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4) [Cleaved into: Ragulator complex protein LAMTOR4, N-terminally processed]	LAMTOR4 C7orf59	Homo sapiens (Human)	99	intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; Ragulator complex [GO:0071986]; cellular response to amino acid stimulus [GO:0071230]; positive regulation of GTPase activity [GO:0043547]; positive regulation of TOR signaling [GO:0032008]; protein localization to lysosome [GO:0061462]; regulation of cell size [GO:0008361]	cellular response to amino acid stimulus [GO:0071230]; positive regulation of GTPase activity [GO:0043547]; positive regulation of TOR signaling [GO:0032008]; protein localization to lysosome [GO:0061462]; regulation of cell size [GO:0008361]		intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; Ragulator complex [GO:0071986]	GO:0071986; GO:0071230; GO:0043231; GO:0005764; GO:0043547; GO:0032008; GO:0061462; GO:0008361	SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:22980980}.	Acetylation; Complete proteome; Lysosome; Reference proteome	Chain (2); Initiator methionine (1); Modified residue (2)
C9JXA7_HUMAN	C9JXA7	C9JXA7_HUMAN	unreviewed	Ragulator complex protein LAMTOR4	LAMTOR4	Homo sapiens (Human)	137							Complete proteome; Proteomics identification; Reference proteome	
BAP18_HUMAN	Q8IXM2	BAP18_HUMAN	reviewed	Chromatin complexes subunit BAP18 (BPTF-associated protein of 18 kDa)	BAP18 C17orf49	Homo sapiens (Human)	172	MLL1 complex [GO:0071339]; NURF complex [GO:0016589]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; chromatin modification [GO:0016568]	chromatin modification [GO:0016568]	chromatin binding [GO:0003682]; DNA binding [GO:0003677]	MLL1 complex [GO:0071339]; NURF complex [GO:0016589]	GO:0003677; GO:0071339; GO:0016589; GO:0003682; GO:0016568	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.	Alternative splicing; Chromatin regulator; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome	Alternative sequence (2); Chain (1); Domain (1); Modified residue (1)
SIAS_HUMAN	Q9NR45	SIAS_HUMAN	reviewed	Sialic acid synthase (N-acetylneuraminate synthase) (EC 2.5.1.56) (N-acetylneuraminate-9-phosphate synthase) (EC 2.5.1.57) (N-acetylneuraminic acid phosphate synthase) (N-acetylneuraminic acid synthase)	NANS SAS	Homo sapiens (Human)	359	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; N-acetylneuraminate synthase activity [GO:0050462]; N-acylneuraminate cytidylyltransferase activity [GO:0008781]; N-acylneuraminate-9-phosphate synthase activity [GO:0047444]; cellular protein metabolic process [GO:0044267]; dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; lipopolysaccharide biosynthetic process [GO:0009103]; post-translational protein modification [GO:0043687]; protein N-linked glycosylation via asparagine [GO:0018279]	cellular protein metabolic process [GO:0044267]; dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; lipopolysaccharide biosynthetic process [GO:0009103]; post-translational protein modification [GO:0043687]; protein N-linked glycosylation via asparagine [GO:0018279]	N-acetylneuraminate synthase activity [GO:0050462]; N-acylneuraminate-9-phosphate synthase activity [GO:0047444]; N-acylneuraminate cytidylyltransferase activity [GO:0008781]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0050462; GO:0008781; GO:0047444; GO:0044267; GO:0005737; GO:0005829; GO:0006488; GO:0070062; GO:0009103; GO:0043687; GO:0018279		3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Polymorphism; Reference proteome; Transferase	Beta strand (5); Chain (1); Domain (1); Helix (3); Initiator methionine (1); Modified residue (1); Natural variant (1); Sequence conflict (2)
HDAC6_HUMAN	Q9UBN7	HDAC6_HUMAN	reviewed	Histone deacetylase 6 (HD6) (EC 3.5.1.98)	HDAC6 KIAA0901 JM21	Homo sapiens (Human)	1215	aggresome [GO:0016235]; axon [GO:0030424]; caveola [GO:0005901]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; dendrite [GO:0030425]; histone deacetylase complex [GO:0000118]; inclusion body [GO:0016234]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; alpha-tubulin binding [GO:0043014]; beta-catenin binding [GO:0008013]; core promoter binding [GO:0001047]; dynein complex binding [GO:0070840]; enzyme binding [GO:0019899]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; Hsp90 protein binding [GO:0051879]; microtubule binding [GO:0008017]; misfolded protein binding [GO:0051787]; NAD-dependent histone deacetylase activity (H3-K14 specific) [GO:0032041]; NAD-dependent histone deacetylase activity (H3-K18 specific) [GO:0097372]; NAD-dependent histone deacetylase activity (H3-K9 specific) [GO:0046969]; NAD-dependent histone deacetylase activity (H4-K16 specific) [GO:0046970]; polyubiquitin binding [GO:0031593]; tau protein binding [GO:0048156]; tubulin deacetylase activity [GO:0042903]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]; aggresome assembly [GO:0070842]; cellular response to heat [GO:0034605]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to misfolded protein [GO:0071218]; cellular response to topologically incorrect protein [GO:0035967]; histone deacetylation [GO:0016575]; Hsp90 deacetylation [GO:0070846]; intracellular protein transport [GO:0006886]; lysosome localization [GO:0032418]; macroautophagy [GO:0016236]; misfolded or incompletely synthesized protein catabolic process [GO:0006515]; negative regulation of hydrogen peroxide metabolic process [GO:0010727]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of oxidoreductase activity [GO:0051354]; negative regulation of protein complex disassembly [GO:0043242]; negative regulation of proteolysis [GO:0045861]; negative regulation of transcription, DNA-templated [GO:0045892]; organelle organization [GO:0006996]; peptidyl-lysine deacetylation [GO:0034983]; polyubiquitinated misfolded protein transport [GO:0070845]; positive regulation of chaperone-mediated protein complex assembly [GO:0090035]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of hydrogen peroxide-mediated programmed cell death [GO:1901300]; positive regulation of receptor biosynthetic process [GO:0010870]; positive regulation of signal transduction [GO:0009967]; protein complex disassembly [GO:0043241]; protein deacetylation [GO:0006476]; protein polyubiquitination [GO:0000209]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of establishment of protein localization [GO:0070201]; regulation of fat cell differentiation [GO:0045598]; regulation of gene expression, epigenetic [GO:0040029]; regulation of microtubule-based movement [GO:0060632]; regulation of receptor activity [GO:0010469]; response to growth factor [GO:0070848]; response to misfolded protein [GO:0051788]; response to organic substance [GO:0010033]; response to toxic substance [GO:0009636]; transcription, DNA-templated [GO:0006351]; tubulin deacetylation [GO:0090042]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]	aggresome assembly [GO:0070842]; cellular response to heat [GO:0034605]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to misfolded protein [GO:0071218]; cellular response to topologically incorrect protein [GO:0035967]; histone deacetylation [GO:0016575]; Hsp90 deacetylation [GO:0070846]; intracellular protein transport [GO:0006886]; lysosome localization [GO:0032418]; macroautophagy [GO:0016236]; misfolded or incompletely synthesized protein catabolic process [GO:0006515]; negative regulation of hydrogen peroxide metabolic process [GO:0010727]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of oxidoreductase activity [GO:0051354]; negative regulation of protein complex disassembly [GO:0043242]; negative regulation of proteolysis [GO:0045861]; negative regulation of transcription, DNA-templated [GO:0045892]; organelle organization [GO:0006996]; peptidyl-lysine deacetylation [GO:0034983]; polyubiquitinated misfolded protein transport [GO:0070845]; positive regulation of chaperone-mediated protein complex assembly [GO:0090035]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of hydrogen peroxide-mediated programmed cell death [GO:1901300]; positive regulation of receptor biosynthetic process [GO:0010870]; positive regulation of signal transduction [GO:0009967]; protein complex disassembly [GO:0043241]; protein deacetylation [GO:0006476]; protein polyubiquitination [GO:0000209]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of establishment of protein localization [GO:0070201]; regulation of fat cell differentiation [GO:0045598]; regulation of gene expression, epigenetic [GO:0040029]; regulation of microtubule-based movement [GO:0060632]; regulation of receptor activity [GO:0010469]; response to growth factor [GO:0070848]; response to misfolded protein [GO:0051788]; response to organic substance [GO:0010033]; response to toxic substance [GO:0009636]; transcription, DNA-templated [GO:0006351]; tubulin deacetylation [GO:0090042]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]	alpha-tubulin binding [GO:0043014]; beta-catenin binding [GO:0008013]; core promoter binding [GO:0001047]; dynein complex binding [GO:0070840]; enzyme binding [GO:0019899]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; Hsp90 protein binding [GO:0051879]; microtubule binding [GO:0008017]; misfolded protein binding [GO:0051787]; NAD-dependent histone deacetylase activity (H3-K14 specific) [GO:0032041]; NAD-dependent histone deacetylase activity (H3-K18 specific) [GO:0097372]; NAD-dependent histone deacetylase activity (H3-K9 specific) [GO:0046969]; NAD-dependent histone deacetylase activity (H4-K16 specific) [GO:0046970]; polyubiquitin binding [GO:0031593]; tau protein binding [GO:0048156]; tubulin deacetylase activity [GO:0042903]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]	aggresome [GO:0016235]; axon [GO:0030424]; caveola [GO:0005901]; cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; dendrite [GO:0030425]; histone deacetylase complex [GO:0000118]; inclusion body [GO:0016234]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]	GO:0070846; GO:0051879; GO:0032041; GO:0097372; GO:0046969; GO:0046970; GO:0016235; GO:0070842; GO:0043014; GO:0030424; GO:0008013; GO:0005901; GO:0031252; GO:0034605; GO:0070301; GO:0071218; GO:0035967; GO:0001047; GO:0005737; GO:0005881; GO:0005829; GO:0030425; GO:0070840; GO:0019899; GO:0004407; GO:0042826; GO:0000118; GO:0016575; GO:0016234; GO:0006886; GO:0032418; GO:0016236; GO:0005874; GO:0005875; GO:0008017; GO:0006515; GO:0051787; GO:0010727; GO:0007026; GO:0051354; GO:0043242; GO:0045861; GO:0045892; GO:0005654; GO:0005634; GO:0006996; GO:0034983; GO:0043204; GO:0048471; GO:0031593; GO:0070845; GO:0090035; GO:0010634; GO:1901300; GO:0010870; GO:0009967; GO:0043241; GO:0006476; GO:0000209; GO:0060765; GO:0070201; GO:0045598; GO:0040029; GO:0060632; GO:0010469; GO:0070848; GO:0051788; GO:0010033; GO:0009636; GO:0048156; GO:0006351; GO:0042903; GO:0090042; GO:0031625; GO:0043162; GO:0008270	SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Perikaryon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, axon {ECO:0000250}. Note=It is mainly cytoplasmic, where it is associated with microtubules.	3D-structure; Actin-binding; Alternative splicing; Autophagy; Cell projection; Chromatin regulator; Complete proteome; Cytoplasm; Hydrolase; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger	Active site (2); Alternative sequence (1); Beta strand (5); Chain (1); Erroneous initiation (1); Helix (4); Metal binding (12); Modified residue (7); Mutagenesis (2); Natural variant (2); Region (4); Turn (5); Zinc finger (1)
OAT_HUMAN	P04181	OAT_HUMAN	reviewed	Ornithine aminotransferase, mitochondrial (EC 2.6.1.13) (Ornithine delta-aminotransferase) (Ornithine--oxo-acid aminotransferase) [Cleaved into: Ornithine aminotransferase, hepatic form; Ornithine aminotransferase, renal form]	OAT	Homo sapiens (Human)	439	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ornithine-oxo-acid transaminase activity [GO:0004587]; pyridoxal phosphate binding [GO:0030170]; cellular amino acid biosynthetic process [GO:0008652]; cellular nitrogen compound metabolic process [GO:0034641]; L-proline biosynthetic process [GO:0055129]; protein hexamerization [GO:0034214]; small molecule metabolic process [GO:0044281]; visual perception [GO:0007601]	cellular amino acid biosynthetic process [GO:0008652]; cellular nitrogen compound metabolic process [GO:0034641]; L-proline biosynthetic process [GO:0055129]; protein hexamerization [GO:0034214]; small molecule metabolic process [GO:0044281]; visual perception [GO:0007601]	ornithine-oxo-acid transaminase activity [GO:0004587]; pyridoxal phosphate binding [GO:0030170]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0055129; GO:0008652; GO:0034641; GO:0005759; GO:0005739; GO:0004587; GO:0034214; GO:0030170; GO:0044281; GO:0007601	SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:23076989}.	3D-structure; Acetylation; Alternative splicing; Aminotransferase; Complete proteome; Direct protein sequencing; Disease mutation; Mitochondrion; Polymorphism; Pyridoxal phosphate; Reference proteome; Transferase; Transit peptide	Alternative sequence (1); Beta strand (16); Chain (2); Helix (16); Modified residue (13); Natural variant (29); Transit peptide (2); Turn (4)
UBAP2_HUMAN	Q5T6F2	UBAP2_HUMAN	reviewed	Ubiquitin-associated protein 2 (UBAP-2)	UBAP2 KIAA1491	Homo sapiens (Human)	1119	poly(A) RNA binding [GO:0044822]		poly(A) RNA binding [GO:0044822]		GO:0044822		Alternative splicing; Coiled coil; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome	Alternative sequence (1); Chain (1); Coiled coil (1); Domain (1); Erroneous initiation (2); Modified residue (2); Natural variant (5)
E9PK45_HUMAN	E9PK45	E9PK45_HUMAN	unreviewed	Ferritin heavy chain	FTH1	Homo sapiens (Human)	102	cell [GO:0005623]; ferric iron binding [GO:0008199]; cellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826]	cellular iron ion homeostasis [GO:0006879]; iron ion transport [GO:0006826]	ferric iron binding [GO:0008199]	cell [GO:0005623]	GO:0005623; GO:0006879; GO:0008199; GO:0006826		Complete proteome; Proteomics identification; Reference proteome	
CHRD1_HUMAN	Q9UHD1	CHRD1_HUMAN	reviewed	Cysteine and histidine-rich domain-containing protein 1 (CHORD domain-containing protein 1) (CHORD-containing protein 1) (CHP-1) (Protein morgana)	CHORDC1 CHP1	Homo sapiens (Human)	332	Hsp90 protein binding [GO:0051879]; zinc ion binding [GO:0008270]; chaperone-mediated protein folding [GO:0061077]; negative regulation of Rho-dependent protein serine/threonine kinase activity [GO:2000299]; regulation of cellular response to heat [GO:1900034]; regulation of centrosome duplication [GO:0010824]	chaperone-mediated protein folding [GO:0061077]; negative regulation of Rho-dependent protein serine/threonine kinase activity [GO:2000299]; regulation of cellular response to heat [GO:1900034]; regulation of centrosome duplication [GO:0010824]	Hsp90 protein binding [GO:0051879]; zinc ion binding [GO:0008270]		GO:0051879; GO:0061077; GO:2000299; GO:1900034; GO:0010824; GO:0008270		3D-structure; Acetylation; Alternative splicing; Chaperone; Complete proteome; Direct protein sequencing; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Stress response; Zinc	Alternative sequence (1); Beta strand (3); Chain (1); Domain (3); Erroneous initiation (1); Helix (1); Initiator methionine (1); Metal binding (16); Modified residue (3); Natural variant (1); Region (2); Sequence conflict (2); Turn (3)
THIOM_HUMAN	Q99757	THIOM_HUMAN	reviewed	Thioredoxin, mitochondrial (MTRX) (Mt-Trx) (Thioredoxin-2)	TXN2 TRX2	Homo sapiens (Human)	166	cytoplasm [GO:0005737]; dendrite [GO:0030425]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [GO:0016671]; peptide-methionine (R)-S-oxide reductase activity [GO:0033743]; peptide-methionine (S)-S-oxide reductase activity [GO:0008113]; protein disulfide oxidoreductase activity [GO:0015035]; cell redox homeostasis [GO:0045454]; cellular response to nutrient levels [GO:0031669]; cellular response to oxidative stress [GO:0034599]; glycerol ether metabolic process [GO:0006662]; oxidation-reduction process [GO:0055114]; protein folding [GO:0006457]; response to axon injury [GO:0048678]; response to drug [GO:0042493]; response to glucose [GO:0009749]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666]; response to nutrient [GO:0007584]; response to organic cyclic compound [GO:0014070]; response to reactive oxygen species [GO:0000302]; sulfate assimilation [GO:0000103]	cell redox homeostasis [GO:0045454]; cellular response to nutrient levels [GO:0031669]; cellular response to oxidative stress [GO:0034599]; glycerol ether metabolic process [GO:0006662]; oxidation-reduction process [GO:0055114]; protein folding [GO:0006457]; response to axon injury [GO:0048678]; response to drug [GO:0042493]; response to glucose [GO:0009749]; response to hormone [GO:0009725]; response to hypoxia [GO:0001666]; response to nutrient [GO:0007584]; response to organic cyclic compound [GO:0014070]; response to reactive oxygen species [GO:0000302]; sulfate assimilation [GO:0000103]	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [GO:0016671]; peptide-methionine (R)-S-oxide reductase activity [GO:0033743]; peptide-methionine (S)-S-oxide reductase activity [GO:0008113]; protein disulfide oxidoreductase activity [GO:0015035]	cytoplasm [GO:0005737]; dendrite [GO:0030425]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]	GO:0045454; GO:0031669; GO:0034599; GO:0005737; GO:0030425; GO:0006662; GO:0005759; GO:0005739; GO:0043025; GO:0005730; GO:0055114; GO:0016671; GO:0033743; GO:0008113; GO:0015035; GO:0006457; GO:0048678; GO:0042493; GO:0009749; GO:0009725; GO:0001666; GO:0007584; GO:0014070; GO:0000302; GO:0000103	SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:12032145, ECO:0000269|PubMed:12080052}.	3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Disulfide bond; Electron transport; Mitochondrion; Redox-active center; Reference proteome; Transit peptide; Transport	Active site (2); Beta strand (5); Chain (1); Disulfide bond (1); Domain (1); Helix (4); Modified residue (2); Sequence conflict (2); Site (3); Transit peptide (1); Turn (3)
F8WDN2_HUMAN	F8WDN2	F8WDN2_HUMAN	unreviewed	Thioredoxin, mitochondrial	TXN2	Homo sapiens (Human)	146	cytoplasm [GO:0005737]; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [GO:0016671]; protein disulfide oxidoreductase activity [GO:0015035]; cell redox homeostasis [GO:0045454]; cellular response to oxidative stress [GO:0034599]; glycerol ether metabolic process [GO:0006662]; oxidation-reduction process [GO:0055114]; protein folding [GO:0006457]; sulfate assimilation [GO:0000103]	cell redox homeostasis [GO:0045454]; cellular response to oxidative stress [GO:0034599]; glycerol ether metabolic process [GO:0006662]; oxidation-reduction process [GO:0055114]; protein folding [GO:0006457]; sulfate assimilation [GO:0000103]	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [GO:0016671]; protein disulfide oxidoreductase activity [GO:0015035]	cytoplasm [GO:0005737]	GO:0045454; GO:0034599; GO:0005737; GO:0006662; GO:0055114; GO:0016671; GO:0015035; GO:0006457; GO:0000103		Complete proteome; Proteomics identification; Reference proteome	
C9J4U1_HUMAN	C9J4U1	C9J4U1_HUMAN	unreviewed	Importin subunit alpha-5 (Fragment)	KPNA1	Homo sapiens (Human)	215	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein transporter activity [GO:0008565]; protein import into nucleus [GO:0006606]	protein import into nucleus [GO:0006606]	protein transporter activity [GO:0008565]	cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]	GO:0005737; GO:0005654; GO:0005634; GO:0006606; GO:0008565		Complete proteome; Proteomics identification; Reference proteome	Non-terminal residue (1)
PDLI1_HUMAN	O00151	PDLI1_HUMAN	reviewed	PDZ and LIM domain protein 1 (C-terminal LIM domain protein 1) (Elfin) (LIM domain protein CLP-36)	PDLIM1 CLIM1 CLP36	Homo sapiens (Human)	329	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925]; transcription factor complex [GO:0005667]; transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270]; regulation of transcription, DNA-templated [GO:0006355]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979]	regulation of transcription, DNA-templated [GO:0006355]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979]	transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270]	cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925]; transcription factor complex [GO:0005667]	GO:0005737; GO:0005856; GO:0005925; GO:0006355; GO:0001666; GO:0006979; GO:0003713; GO:0005667; GO:0008270	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Associates with the actin stress fibers. {ECO:0000250}.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; LIM domain; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Zinc	Beta strand (8); Chain (1); Domain (2); Helix (5); Initiator methionine (1); Metal binding (8); Modified residue (5); Natural variant (1); Sequence conflict (1); Turn (1)
G3V5K1_HUMAN	G3V5K1	G3V5K1_HUMAN	unreviewed	Protein transport protein Sec23A (Fragment)	SEC23A	Homo sapiens (Human)	40							Complete proteome; Proteomics identification; Reference proteome	Non-terminal residue (1)
CAND1_HUMAN	Q86VP6	CAND1_HUMAN	reviewed	Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1)	CAND1 KIAA0829 TIP120 TIP120A	Homo sapiens (Human)	1230	cullin-RING ubiquitin ligase complex [GO:0031461]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; cell differentiation [GO:0030154]; negative regulation of catalytic activity [GO:0043086]; positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [GO:0045899]; protein ubiquitination [GO:0016567]; SCF complex assembly [GO:0010265]	cell differentiation [GO:0030154]; negative regulation of catalytic activity [GO:0043086]; positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [GO:0045899]; protein ubiquitination [GO:0016567]; SCF complex assembly [GO:0010265]		cullin-RING ubiquitin ligase complex [GO:0031461]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]	GO:0010265; GO:0030154; GO:0031461; GO:0005737; GO:0070062; GO:0016020; GO:0043086; GO:0005654; GO:0005634; GO:0045899; GO:0016567; GO:0000151	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21249194}. Nucleus {ECO:0000269|PubMed:21249194}. Note=Predominantly cytoplasmic.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Ubl conjugation pathway	Alternative sequence (4); Beta strand (13); Chain (1); Compositional bias (1); Erroneous initiation (2); Helix (73); Initiator methionine (1); Modified residue (4); Natural variant (2); Repeat (27); Sequence conflict (6); Turn (14)
HCDH_HUMAN	Q16836	HCDH_HUMAN	reviewed	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HCDH) (EC 1.1.1.35) (Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase) (Short-chain 3-hydroxyacyl-CoA dehydrogenase)	HADH HAD HADHSC SCHAD	Homo sapiens (Human)	314	cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; 3-hydroxyacyl-CoA dehydrogenase activity [GO:0003857]; NAD+ binding [GO:0070403]; cellular lipid metabolic process [GO:0044255]; fatty acid beta-oxidation [GO:0006635]; negative regulation of insulin secretion [GO:0046676]; response to activity [GO:0014823]; response to drug [GO:0042493]; response to insulin [GO:0032868]; small molecule metabolic process [GO:0044281]	cellular lipid metabolic process [GO:0044255]; fatty acid beta-oxidation [GO:0006635]; negative regulation of insulin secretion [GO:0046676]; response to activity [GO:0014823]; response to drug [GO:0042493]; response to insulin [GO:0032868]; small molecule metabolic process [GO:0044281]	3-hydroxyacyl-CoA dehydrogenase activity [GO:0003857]; NAD+ binding [GO:0070403]	cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]	GO:0003857; GO:0070403; GO:0044255; GO:0005737; GO:0006635; GO:0005743; GO:0005759; GO:0005739; GO:0046676; GO:0005654; GO:0014823; GO:0042493; GO:0032868; GO:0044281	SUBCELLULAR LOCATION: Mitochondrion matrix.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Disease mutation; Fatty acid metabolism; Lipid metabolism; Mitochondrion; NAD; Oxidoreductase; Polymorphism; Reference proteome; Transit peptide	Alternative sequence (2); Beta strand (11); Binding site (9); Chain (1); Helix (17); Modified residue (22); Natural variant (5); Nucleotide binding (1); Sequence conflict (2); Site (1); Transit peptide (1); Turn (5)
SYYC_HUMAN	P54577	SYYC_HUMAN	reviewed	Tyrosine--tRNA ligase, cytoplasmic (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS) [Cleaved into: Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed]	YARS	Homo sapiens (Human)	528	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleus [GO:0005634]; ATP binding [GO:0005524]; interleukin-8 receptor binding [GO:0005153]; poly(A) RNA binding [GO:0044822]; signal transducer activity [GO:0004871]; tRNA binding [GO:0000049]; tyrosine-tRNA ligase activity [GO:0004831]; apoptotic process [GO:0006915]; gene expression [GO:0010467]; signal transduction [GO:0007165]; tRNA aminoacylation for protein translation [GO:0006418]; tyrosyl-tRNA aminoacylation [GO:0006437]	apoptotic process [GO:0006915]; gene expression [GO:0010467]; signal transduction [GO:0007165]; tRNA aminoacylation for protein translation [GO:0006418]; tyrosyl-tRNA aminoacylation [GO:0006437]	ATP binding [GO:0005524]; interleukin-8 receptor binding [GO:0005153]; poly(A) RNA binding [GO:0044822]; signal transducer activity [GO:0004871]; tRNA binding [GO:0000049]; tyrosine-tRNA ligase activity [GO:0004831]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleus [GO:0005634]	GO:0005524; GO:0006915; GO:0005737; GO:0005829; GO:0005615; GO:0010467; GO:0005153; GO:0005634; GO:0044822; GO:0004871; GO:0007165; GO:0006418; GO:0000049; GO:0004831; GO:0006437	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16429158}.	3D-structure; ATP-binding; Acetylation; Aminoacyl-tRNA synthetase; Charcot-Marie-Tooth disease; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Ligase; Neurodegeneration; Neuropathy; Nucleotide-binding; Polymorphism; Protein biosynthesis; RNA-binding; Reference proteome; tRNA-binding	Beta strand (23); Binding site (5); Chain (2); Domain (1); Frameshift (1); Helix (23); Initiator methionine (1); Modified residue (7); Motif (2); Natural variant (5); Sequence conflict (1); Turn (6)
RCC2_HUMAN	Q9P258	RCC2_HUMAN	reviewed	Protein RCC2 (RCC1-like protein TD-60) (Telophase disk protein of 60 kDa)	RCC2 KIAA1470 TD60	Homo sapiens (Human)	522	chromosome, centromeric core domain [GO:0034506]; cytosol [GO:0005829]; microtubule [GO:0005874]; midbody [GO:0030496]; mitotic spindle midzone [GO:1990023]; nucleolus [GO:0005730]; microtubule binding [GO:0008017]; poly(A) RNA binding [GO:0044822]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; Rac GTPase binding [GO:0048365]; small GTPase binding [GO:0031267]; cell division [GO:0051301]; chromosome passenger complex localization to kinetochore [GO:0072356]; endosome organization [GO:0007032]; focal adhesion assembly [GO:0048041]; integrin-mediated signaling pathway [GO:0007229]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of GTPase activity [GO:0034260]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; positive regulation of attachment of spindle microtubules to kinetochore [GO:0051987]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; regulation of cell migration [GO:0030334]; small GTPase mediated signal transduction [GO:0007264]	cell division [GO:0051301]; chromosome passenger complex localization to kinetochore [GO:0072356]; endosome organization [GO:0007032]; focal adhesion assembly [GO:0048041]; integrin-mediated signaling pathway [GO:0007229]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0007067]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of GTPase activity [GO:0034260]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; positive regulation of attachment of spindle microtubules to kinetochore [GO:0051987]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; regulation of cell migration [GO:0030334]; small GTPase mediated signal transduction [GO:0007264]	microtubule binding [GO:0008017]; poly(A) RNA binding [GO:0044822]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; Rac GTPase binding [GO:0048365]; small GTPase binding [GO:0031267]	chromosome, centromeric core domain [GO:0034506]; cytosol [GO:0005829]; microtubule [GO:0005874]; midbody [GO:0030496]; mitotic spindle midzone [GO:1990023]; nucleolus [GO:0005730]	GO:0048365; GO:0051301; GO:0072356; GO:0034506; GO:0005829; GO:0007032; GO:0048041; GO:0007229; GO:0005874; GO:0008017; GO:0030496; GO:0000278; GO:0007067; GO:1990023; GO:0034260; GO:0051895; GO:1900025; GO:0005730; GO:0044822; GO:0010971; GO:0051987; GO:0019904; GO:0019901; GO:0030334; GO:0031267; GO:0007264	SUBCELLULAR LOCATION: Nucleus, nucleolus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Appears in the nucleus at G2, then concentrates at the inner centromere region of chromosomes during prophase. Redistributes to the midzone of the mitotic spindle during anaphase. Here, the protein covers the entire equatorial diameter from cortex to cortex.	Acetylation; Cell cycle; Cell division; Centromere; Chromosome; Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Mitosis; Nucleus; Phosphoprotein; Reference proteome; Repeat	Chain (1); Erroneous initiation (1); Frameshift (1); Modified residue (13); Repeat (7); Sequence conflict (1)
DBNL_HUMAN	Q9UJU6	DBNL_HUMAN	reviewed	Drebrin-like protein (Cervical SH3P7) (Cervical mucin-associated protein) (Drebrin-F) (HPK1-interacting protein of 55 kDa) (HIP-55) (SH3 domain-containing protein 7)	DBNL CMAP SH3P7 PP5423	Homo sapiens (Human)	430	cell cortex [GO:0005938]; cell junction [GO:0030054]; clathrin-coated vesicle membrane [GO:0030665]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; podosome [GO:0002102]; postsynaptic density [GO:0014069]; ruffle [GO:0001726]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; enzyme activator activity [GO:0008047]; activation of JUN kinase activity [GO:0007257]; apoptotic process [GO:0006915]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; immune system process [GO:0002376]; neuron projection morphogenesis [GO:0048812]; podosome assembly [GO:0071800]; programmed cell death [GO:0012501]; Rac protein signal transduction [GO:0016601]; receptor-mediated endocytosis [GO:0006898]; ruffle assembly [GO:0097178]; synapse assembly [GO:0007416]	activation of JUN kinase activity [GO:0007257]; apoptotic process [GO:0006915]; cellular component disassembly involved in execution phase of apoptosis [GO:0006921]; immune system process [GO:0002376]; neuron projection morphogenesis [GO:0048812]; podosome assembly [GO:0071800]; programmed cell death [GO:0012501]; Rac protein signal transduction [GO:0016601]; receptor-mediated endocytosis [GO:0006898]; ruffle assembly [GO:0097178]; synapse assembly [GO:0007416]	actin binding [GO:0003779]; actin filament binding [GO:0051015]; enzyme activator activity [GO:0008047]	cell cortex [GO:0005938]; cell junction [GO:0030054]; clathrin-coated vesicle membrane [GO:0030665]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; podosome [GO:0002102]; postsynaptic density [GO:0014069]; ruffle [GO:0001726]	GO:0000139; GO:0016601; GO:0003779; GO:0051015; GO:0007257; GO:0006915; GO:0005938; GO:0030054; GO:0006921; GO:0030665; GO:0005737; GO:0005829; GO:0030425; GO:0008047; GO:0070062; GO:0002376; GO:0030027; GO:0048812; GO:0005886; GO:0002102; GO:0071800; GO:0014069; GO:0012501; GO:0006898; GO:0001726; GO:0097178; GO:0007416	SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell projection {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell projection, podosome {ECO:0000250}. Note=Detected in neuron cell body and cell projections, such as neurites. Colocalizes with cytosolic dynamin in hippocampus neurons (By similarity). Cortical actin cytoskeleton. Associates with lamellipodial actin and membrane ruffles. Colocalizes with actin and cortactin at podosome dots and podosome rosettes (By similarity). {ECO:0000250}.	3D-structure; Acetylation; Actin-binding; Adaptive immunity; Alternative splicing; Cell junction; Cell membrane; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Endocytosis; Golgi apparatus; Immunity; Membrane; Phosphoprotein; Reference proteome; SH3 domain; Synapse; Transport	Alternative sequence (5); Beta strand (7); Chain (1); Coiled coil (1); Domain (2); Helix (5); Modified residue (8); Mutagenesis (1); Sequence conflict (6); Site (1); Turn (1)
F5GWY6_HUMAN	F5GWY6	F5GWY6_HUMAN	unreviewed	Elongator complex protein 2	ELP2	Homo sapiens (Human)	51							Complete proteome; Proteomics identification; Reference proteome	
CG055_HUMAN	Q96HJ9	CG055_HUMAN	reviewed	UPF0562 protein C7orf55	C7orf55 HSPC268	Homo sapiens (Human)	113	mitochondrion [GO:0005739]			mitochondrion [GO:0005739]	GO:0005739		Alternative splicing; Complete proteome; Polymorphism; Reference proteome	Alternative sequence (1); Chain (1); Erroneous initiation (1); Frameshift (1); Natural variant (1)
DHAK_HUMAN	Q3LXA3	DHAK_HUMAN	reviewed	Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing) [Includes: ATP-dependent dihydroxyacetone kinase (DHA kinase) (EC 2.7.1.28) (EC 2.7.1.29) (Glycerone kinase) (Triokinase) (Triose kinase); FAD-AMP lyase (cyclizing) (EC 4.6.1.15) (FAD-AMP lyase (cyclic FMN forming)) (FMN cyclase)]	DAK	Homo sapiens (Human)	575	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; ATP binding [GO:0005524]; FAD-AMP lyase (cyclizing) activity [GO:0034012]; glycerone kinase activity [GO:0004371]; metal ion binding [GO:0046872]; triokinase activity [GO:0050354]; carbohydrate metabolic process [GO:0005975]; carbohydrate phosphorylation [GO:0046835]; cellular carbohydrate metabolic process [GO:0044262]; fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate [GO:0061624]; fructose metabolic process [GO:0006000]; glycerol metabolic process [GO:0006071]; innate immune response [GO:0045087]; regulation of innate immune response [GO:0045088]; small molecule metabolic process [GO:0044281]	carbohydrate metabolic process [GO:0005975]; carbohydrate phosphorylation [GO:0046835]; cellular carbohydrate metabolic process [GO:0044262]; fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate [GO:0061624]; fructose metabolic process [GO:0006000]; glycerol metabolic process [GO:0006071]; innate immune response [GO:0045087]; regulation of innate immune response [GO:0045088]; small molecule metabolic process [GO:0044281]	ATP binding [GO:0005524]; FAD-AMP lyase (cyclizing) activity [GO:0034012]; glycerone kinase activity [GO:0004371]; metal ion binding [GO:0046872]; triokinase activity [GO:0050354]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]	GO:0005524; GO:0034012; GO:0005975; GO:0046835; GO:0044262; GO:0005829; GO:0070062; GO:0061624; GO:0006000; GO:0006071; GO:0004371; GO:0045087; GO:0046872; GO:0005634; GO:0045088; GO:0044281; GO:0050354		ATP-binding; Alternative splicing; Cobalt; Complete proteome; FAD; Flavoprotein; Kinase; Lyase; Magnesium; Manganese; Metal-binding; Multifunctional enzyme; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Transferase	Active site (1); Alternative sequence (1); Binding site (3); Chain (1); Domain (2); Modified residue (2); Natural variant (2); Nucleotide binding (4); Region (1); Sequence conflict (5)
RL30_HUMAN	P62888	RL30_HUMAN	reviewed	60S ribosomal protein L30	RPL30	Homo sapiens (Human)	115	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	cellular protein metabolic process [GO:0044267]; gene expression [GO:0010467]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]; translational termination [GO:0006415]; viral life cycle [GO:0019058]; viral process [GO:0016032]; viral transcription [GO:0019083]	poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]	GO:0003723; GO:0006614; GO:0044267; GO:0005737; GO:0005829; GO:0022625; GO:0070062; GO:0005925; GO:0010467; GO:0016020; GO:0000184; GO:0005634; GO:0044822; GO:0003735; GO:0006412; GO:0006414; GO:0006413; GO:0006415; GO:0019058; GO:0016032; GO:0019083		3D-structure; Acetylation; Complete proteome; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein	Beta strand (4); Chain (1); Helix (4); Modified residue (2)
SUCB1_HUMAN	Q9P2R7	SUCB1_HUMAN	reviewed	Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (ATP-specific succinyl-CoA synthetase subunit beta) (Renal carcinoma antigen NY-REN-39) (Succinyl-CoA synthetase beta-A chain) (SCS-betaA)	SUCLA2	Homo sapiens (Human)	463	extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; succinate-CoA ligase (ADP-forming) activity [GO:0004775]; cellular metabolic process [GO:0044237]; small molecule metabolic process [GO:0044281]; succinate metabolic process [GO:0006105]; succinyl-CoA metabolic process [GO:0006104]; succinyl-CoA pathway [GO:0006781]; tricarboxylic acid cycle [GO:0006099]	cellular metabolic process [GO:0044237]; small molecule metabolic process [GO:0044281]; succinate metabolic process [GO:0006105]; succinyl-CoA metabolic process [GO:0006104]; succinyl-CoA pathway [GO:0006781]; tricarboxylic acid cycle [GO:0006099]	ATP binding [GO:0005524]; metal ion binding [GO:0046872]; succinate-CoA ligase (ADP-forming) activity [GO:0004775]	extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0005524; GO:0044237; GO:0070062; GO:0046872; GO:0005759; GO:0005739; GO:0044281; GO:0006105; GO:0004775; GO:0006104; GO:0006781; GO:0006099	SUBCELLULAR LOCATION: Mitochondrion.	ATP-binding; Acetylation; Alternative splicing; Complete proteome; Disease mutation; Ligase; Mitochondrion; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Transit peptide; Tricarboxylic acid cycle	Alternative sequence (1); Chain (1); Domain (1); Modified residue (9); Natural variant (5); Sequence conflict (3); Transit peptide (1)
RFA3_HUMAN	P35244	RFA3_HUMAN	reviewed	Replication protein A 14 kDa subunit (RP-A p14) (Replication factor A protein 3) (RF-A protein 3)	RPA3 REPA3 RPA14	Homo sapiens (Human)	121	DNA replication factor A complex [GO:0005662]; nucleoplasm [GO:0005654]; damaged DNA binding [GO:0003684]; single-stranded DNA binding [GO:0003697]; base-excision repair [GO:0006284]; cellular response to heat [GO:0034605]; DNA damage response, detection of DNA damage [GO:0042769]; DNA recombinase assembly [GO:0000730]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA strand elongation involved in DNA replication [GO:0006271]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; error-free translesion synthesis [GO:0070987]; error-prone translesion synthesis [GO:0042276]; G1/S transition of mitotic cell cycle [GO:0000082]; mismatch repair [GO:0006298]; mitotic cell cycle [GO:0000278]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair, DNA damage removal [GO:0000718]; nucleotide-excision repair, DNA gap filling [GO:0006297]; regulation of cell proliferation [GO:0042127]; regulation of cellular response to heat [GO:1900034]; regulation of mitotic cell cycle [GO:0007346]; telomere maintenance [GO:0000723]; telomere maintenance via recombination [GO:0000722]; telomere maintenance via semi-conservative replication [GO:0032201]; transcription-coupled nucleotide-excision repair [GO:0006283]; translesion synthesis [GO:0019985]	base-excision repair [GO:0006284]; cellular response to heat [GO:0034605]; DNA damage response, detection of DNA damage [GO:0042769]; DNA recombinase assembly [GO:0000730]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA strand elongation involved in DNA replication [GO:0006271]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; error-free translesion synthesis [GO:0070987]; error-prone translesion synthesis [GO:0042276]; G1/S transition of mitotic cell cycle [GO:0000082]; mismatch repair [GO:0006298]; mitotic cell cycle [GO:0000278]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair, DNA damage removal [GO:0000718]; nucleotide-excision repair, DNA gap filling [GO:0006297]; regulation of cell proliferation [GO:0042127]; regulation of cellular response to heat [GO:1900034]; regulation of mitotic cell cycle [GO:0007346]; telomere maintenance [GO:0000723]; telomere maintenance via recombination [GO:0000722]; telomere maintenance via semi-conservative replication [GO:0032201]; transcription-coupled nucleotide-excision repair [GO:0006283]; translesion synthesis [GO:0019985]	damaged DNA binding [GO:0003684]; single-stranded DNA binding [GO:0003697]	DNA replication factor A complex [GO:0005662]; nucleoplasm [GO:0005654]	GO:0042769; GO:0000730; GO:0006281; GO:0006260; GO:0005662; GO:0006271; GO:0000082; GO:0006284; GO:0034605; GO:0003684; GO:0006302; GO:0000724; GO:0070987; GO:0042276; GO:0006298; GO:0000278; GO:0005654; GO:0006289; GO:0000718; GO:0006297; GO:0042127; GO:1900034; GO:0007346; GO:0003697; GO:0000723; GO:0000722; GO:0032201; GO:0006283; GO:0019985	SUBCELLULAR LOCATION: Nucleus.	3D-structure; Acetylation; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA replication; Nucleus; Reference proteome	Beta strand (7); Chain (1); Helix (4); Initiator methionine (1); Modified residue (1)
GNA1_HUMAN	Q96EK6	GNA1_HUMAN	reviewed	Glucosamine 6-phosphate N-acetyltransferase (EC 2.3.1.4) (Phosphoglucosamine acetylase) (Phosphoglucosamine transacetylase)	GNPNAT1 GNA1	Homo sapiens (Human)	184	cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; late endosome [GO:0005770]; glucosamine 6-phosphate N-acetyltransferase activity [GO:0004343]; identical protein binding [GO:0042802]; monosaccharide binding [GO:0048029]; cellular protein metabolic process [GO:0044267]; dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; glucosamine metabolic process [GO:0006041]; liver development [GO:0001889]; N-acetylglucosamine metabolic process [GO:0006044]; post-translational protein modification [GO:0043687]; protein N-linked glycosylation via asparagine [GO:0018279]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]	cellular protein metabolic process [GO:0044267]; dolichol-linked oligosaccharide biosynthetic process [GO:0006488]; glucosamine metabolic process [GO:0006041]; liver development [GO:0001889]; N-acetylglucosamine metabolic process [GO:0006044]; post-translational protein modification [GO:0043687]; protein N-linked glycosylation via asparagine [GO:0018279]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]	glucosamine 6-phosphate N-acetyltransferase activity [GO:0004343]; identical protein binding [GO:0042802]; monosaccharide binding [GO:0048029]	cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; late endosome [GO:0005770]	GO:0000139; GO:0006044; GO:0006048; GO:0044267; GO:0005829; GO:0006488; GO:0005793; GO:0010008; GO:0004343; GO:0006041; GO:0042802; GO:0005770; GO:0001889; GO:0048029; GO:0043687; GO:0018279	SUBCELLULAR LOCATION: Golgi apparatus membrane; Peripheral membrane protein. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.	3D-structure; Acyltransferase; Complete proteome; Endosome; Golgi apparatus; Membrane; Reference proteome; Transferase	Beta strand (8); Binding site (3); Chain (1); Domain (1); Helix (10); Mutagenesis (2); Region (5); Turn (3)
URP2_HUMAN	Q86UX7	URP2_HUMAN	reviewed	Fermitin family homolog 3 (Kindlin-3) (MIG2-like protein) (Unc-112-related protein 2)	FERMT3 KIND3 MIG2B URP2	Homo sapiens (Human)	667	cell junction [GO:0030054]; cell projection [GO:0042995]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; podosome [GO:0002102]; integrin binding [GO:0005178]; integrin activation [GO:0033622]; integrin-mediated signaling pathway [GO:0007229]; leukocyte cell-cell adhesion [GO:0007159]; platelet aggregation [GO:0070527]; regulation of cell-cell adhesion mediated by integrin [GO:0033632]; substrate adhesion-dependent cell spreading [GO:0034446]	integrin activation [GO:0033622]; integrin-mediated signaling pathway [GO:0007229]; leukocyte cell-cell adhesion [GO:0007159]; platelet aggregation [GO:0070527]; regulation of cell-cell adhesion mediated by integrin [GO:0033632]; substrate adhesion-dependent cell spreading [GO:0034446]	integrin binding [GO:0005178]	cell junction [GO:0030054]; cell projection [GO:0042995]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; podosome [GO:0002102]	GO:0030054; GO:0042995; GO:0070062; GO:0033622; GO:0005178; GO:0007229; GO:0007159; GO:0016020; GO:0070527; GO:0002102; GO:0033632; GO:0034446	SUBCELLULAR LOCATION: Cell projection, podosome {ECO:0000250}. Note=Present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells. {ECO:0000250}.	3D-structure; Alternative splicing; Cell adhesion; Cell junction; Cell projection; Complete proteome; Direct protein sequencing; Phosphoprotein; Reference proteome	Alternative sequence (1); Beta strand (6); Chain (1); Compositional bias (1); Domain (2); Helix (3); Modified residue (2); Sequence conflict (2); Turn (2)
D6R9P3_HUMAN	D6R9P3	D6R9P3_HUMAN	unreviewed	Heterogeneous nuclear ribonucleoprotein A/B	HNRNPAB	Homo sapiens (Human)	280	nucleoplasm [GO:0005654]; nucleic acid binding [GO:0003676]; nucleotide binding [GO:0000166]		nucleic acid binding [GO:0003676]; nucleotide binding [GO:0000166]	nucleoplasm [GO:0005654]	GO:0003676; GO:0005654; GO:0000166		Complete proteome; Proteomics identification; Reference proteome	
MK14_HUMAN	Q16539	MK14_HUMAN	reviewed	Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a)	MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	Homo sapiens (Human)	360	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]; ATP binding [GO:0005524]; MAP kinase activity [GO:0004707]; MAP kinase kinase activity [GO:0004708]; NFAT protein binding [GO:0051525]; protein serine/threonine kinase activity [GO:0004674]; 3'-UTR-mediated mRNA stabilization [GO:0070935]; activation of MAPK activity [GO:0000187]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; blood coagulation [GO:0007596]; cartilage condensation [GO:0001502]; cell morphogenesis [GO:0000902]; cell surface receptor signaling pathway [GO:0007166]; cellular response to ionizing radiation [GO:0071479]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; chemotaxis [GO:0006935]; chondrocyte differentiation [GO:0002062]; DNA damage checkpoint [GO:0000077]; fatty acid oxidation [GO:0019395]; gene expression [GO:0010467]; glucose metabolic process [GO:0006006]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; mitochondrion organization [GO:0007005]; movement of cell or subcellular component [GO:0006928]; muscle cell differentiation [GO:0042692]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; MyD88-independent toll-like receptor signaling pathway [GO:0002756]; myoblast differentiation involved in skeletal muscle regeneration [GO:0014835]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; neurotrophin TRK receptor signaling pathway [GO:0048011]; organelle organization [GO:0006996]; osteoclast differentiation [GO:0030316]; p38MAPK cascade [GO:0038066]; peptidyl-serine phosphorylation [GO:0018105]; platelet activation [GO:0030168]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of cyclase activity [GO:0031281]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; Ras protein signal transduction [GO:0007265]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of sequence-specific DNA binding transcription factor activity [GO:0051090]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; response to muramyl dipeptide [GO:0032495]; signal transduction [GO:0007165]; signal transduction in response to DNA damage [GO:0042770]; skeletal muscle tissue development [GO:0007519]; stress-activated MAPK cascade [GO:0051403]; stress-induced premature senescence [GO:0090400]; striated muscle cell differentiation [GO:0051146]; toll-like receptor 10 signaling pathway [GO:0034166]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 5 signaling pathway [GO:0034146]; toll-like receptor 9 signaling pathway [GO:0034162]; toll-like receptor signaling pathway [GO:0002224]; toll-like receptor TLR1:TLR2 signaling pathway [GO:0038123]; toll-like receptor TLR6:TLR2 signaling pathway [GO:0038124]; transcription, DNA-templated [GO:0006351]; transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0007178]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	3'-UTR-mediated mRNA stabilization [GO:0070935]; activation of MAPK activity [GO:0000187]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; blood coagulation [GO:0007596]; cartilage condensation [GO:0001502]; cell morphogenesis [GO:0000902]; cell surface receptor signaling pathway [GO:0007166]; cellular response to ionizing radiation [GO:0071479]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; chemotaxis [GO:0006935]; chondrocyte differentiation [GO:0002062]; DNA damage checkpoint [GO:0000077]; fatty acid oxidation [GO:0019395]; gene expression [GO:0010467]; glucose metabolic process [GO:0006006]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; mitochondrion organization [GO:0007005]; movement of cell or subcellular component [GO:0006928]; muscle cell differentiation [GO:0042692]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; MyD88-independent toll-like receptor signaling pathway [GO:0002756]; myoblast differentiation involved in skeletal muscle regeneration [GO:0014835]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; neurotrophin TRK receptor signaling pathway [GO:0048011]; organelle organization [GO:0006996]; osteoclast differentiation [GO:0030316]; p38MAPK cascade [GO:0038066]; peptidyl-serine phosphorylation [GO:0018105]; platelet activation [GO:0030168]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of cyclase activity [GO:0031281]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of transcription from RNA polymerase II promoter [GO:0045944]; Ras protein signal transduction [GO:0007265]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of sequence-specific DNA binding transcription factor activity [GO:0051090]; regulation of transcription from RNA polymerase II promoter [GO:0006357]; response to muramyl dipeptide [GO:0032495]; signal transduction [GO:0007165]; signal transduction in response to DNA damage [GO:0042770]; skeletal muscle tissue development [GO:0007519]; stress-activated MAPK cascade [GO:0051403]; stress-induced premature senescence [GO:0090400]; striated muscle cell differentiation [GO:0051146]; toll-like receptor 10 signaling pathway [GO:0034166]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor 5 signaling pathway [GO:0034146]; toll-like receptor 9 signaling pathway [GO:0034162]; toll-like receptor signaling pathway [GO:0002224]; toll-like receptor TLR1:TLR2 signaling pathway [GO:0038123]; toll-like receptor TLR6:TLR2 signaling pathway [GO:0038124]; transcription, DNA-templated [GO:0006351]; transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0007178]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]	ATP binding [GO:0005524]; MAP kinase activity [GO:0004707]; MAP kinase kinase activity [GO:0004708]; NFAT protein binding [GO:0051525]; protein serine/threonine kinase activity [GO:0004674]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle pole [GO:0000922]	GO:0070935; GO:0005524; GO:0000077; GO:0004707; GO:0004708; GO:0002755; GO:0002756; GO:0051525; GO:0007265; GO:0035666; GO:0000187; GO:0001525; GO:0006915; GO:0007596; GO:0001502; GO:0000902; GO:0007166; GO:0071479; GO:0071222; GO:0035924; GO:0006935; GO:0002062; GO:0005737; GO:0005829; GO:0070062; GO:0019395; GO:0010467; GO:0006006; GO:0045087; GO:0035556; GO:0031663; GO:0005739; GO:0007005; GO:0006928; GO:0042692; GO:0014835; GO:0090090; GO:0048011; GO:0005654; GO:0005634; GO:0006996; GO:0030316; GO:0038066; GO:0018105; GO:0030168; GO:0090336; GO:0031281; GO:0045648; GO:0051149; GO:0045663; GO:1901741; GO:0010831; GO:0042307; GO:2000379; GO:0045944; GO:0004674; GO:1900015; GO:0051090; GO:0006357; GO:0032495; GO:0007165; GO:0042770; GO:0007519; GO:0000922; GO:0051403; GO:0090400; GO:0051146; GO:0034166; GO:0034134; GO:0034138; GO:0034142; GO:0034146; GO:0034162; GO:0038123; GO:0038124; GO:0002224; GO:0006351; GO:0007178; GO:0048010	SUBCELLULAR LOCATION: Cytoplasm. Nucleus.	3D-structure; ATP-binding; Acetylation; Alternative splicing; Apoptosis; Complete proteome; Cytoplasm; Direct protein sequencing; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Stress response; Transcription; Transcription regulation; Transferase; Ubl conjugation	Active site (1); Alternative sequence (5); Beta strand (13); Binding site (9); Chain (1); Domain (1); Helix (20); Initiator methionine (1); Modified residue (9); Motif (1); Mutagenesis (14); Natural variant (3); Nucleotide binding (1); Region (3); Sequence conflict (1); Turn (8)
EIF3F_HUMAN	O00303	EIF3F_HUMAN	reviewed	Eukaryotic translation initiation factor 3 subunit F (eIF3f) (Deubiquitinating enzyme eIF3f) (EC 3.4.19.12) (Eukaryotic translation initiation factor 3 subunit 5) (eIF-3-epsilon) (eIF3 p47)	EIF3F EIF3S5	Homo sapiens (Human)	357	cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; membrane [GO:0016020]; translation initiation factor activity [GO:0003743]; ubiquitin-specific protease activity [GO:0004843]; cellular protein metabolic process [GO:0044267]; formation of translation preinitiation complex [GO:0001731]; gene expression [GO:0010467]; protein deubiquitination [GO:0016579]; regulation of translational initiation [GO:0006446]; translation [GO:0006412]; translational initiation [GO:0006413]	cellular protein metabolic process [GO:0044267]; formation of translation preinitiation complex [GO:0001731]; gene expression [GO:0010467]; protein deubiquitination [GO:0016579]; regulation of translational initiation [GO:0006446]; translation [GO:0006412]; translational initiation [GO:0006413]	translation initiation factor activity [GO:0003743]; ubiquitin-specific protease activity [GO:0004843]	cytosol [GO:0005829]; eukaryotic 43S preinitiation complex [GO:0016282]; eukaryotic 48S preinitiation complex [GO:0033290]; eukaryotic translation initiation factor 3 complex [GO:0005852]; membrane [GO:0016020]	GO:0044267; GO:0005829; GO:0016282; GO:0033290; GO:0005852; GO:0001731; GO:0010467; GO:0016020; GO:0016579; GO:0006446; GO:0006412; GO:0003743; GO:0006413; GO:0004843	SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03005}.	3D-structure; Acetylation; Complete proteome; Cytoplasm; Hydrolase; Initiation factor; Phosphoprotein; Polymorphism; Protease; Protein biosynthesis; Reference proteome; Thiol protease; Ubl conjugation pathway	Chain (1); Domain (1); Initiator methionine (1); Mass spectrometry (2); Modified residue (4); Natural variant (2); Sequence conflict (1)
CECR5_HUMAN	Q9BXW7	CECR5_HUMAN	reviewed	Cat eye syndrome critical region protein 5	CECR5	Homo sapiens (Human)	423	mitochondrion [GO:0005739]			mitochondrion [GO:0005739]	GO:0005739		Alternative splicing; Complete proteome; Polymorphism; Reference proteome; Signal	Alternative sequence (1); Chain (1); Natural variant (3); Sequence conflict (3); Signal peptide (1)
ACOX1_HUMAN	Q15067	ACOX1_HUMAN	reviewed	Peroxisomal acyl-coenzyme A oxidase 1 (AOX) (EC 1.3.3.6) (Palmitoyl-CoA oxidase) (Straight-chain acyl-CoA oxidase) (SCOX)	ACOX1 ACOX	Homo sapiens (Human)	660	intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; plasma membrane [GO:0005886]; acyl-CoA dehydrogenase activity [GO:0003995]; acyl-CoA oxidase activity [GO:0003997]; FAD binding [GO:0071949]; fatty acid binding [GO:0005504]; flavin adenine dinucleotide binding [GO:0050660]; palmitoyl-CoA oxidase activity [GO:0016401]; PDZ domain binding [GO:0030165]; protein N-terminus binding [GO:0047485]; receptor binding [GO:0005102]; alpha-linolenic acid metabolic process [GO:0036109]; cellular lipid metabolic process [GO:0044255]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; fatty acid oxidation [GO:0019395]; generation of precursor metabolites and energy [GO:0006091]; lipid homeostasis [GO:0055088]; lipid metabolic process [GO:0006629]; peroxisome fission [GO:0016559]; positive regulation of cholesterol homeostasis [GO:2000189]; prostaglandin metabolic process [GO:0006693]; small molecule metabolic process [GO:0044281]; spermatogenesis [GO:0007283]; unsaturated fatty acid metabolic process [GO:0033559]; very long-chain fatty acid metabolic process [GO:0000038]	alpha-linolenic acid metabolic process [GO:0036109]; cellular lipid metabolic process [GO:0044255]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; fatty acid oxidation [GO:0019395]; generation of precursor metabolites and energy [GO:0006091]; lipid homeostasis [GO:0055088]; lipid metabolic process [GO:0006629]; peroxisome fission [GO:0016559]; positive regulation of cholesterol homeostasis [GO:2000189]; prostaglandin metabolic process [GO:0006693]; small molecule metabolic process [GO:0044281]; spermatogenesis [GO:0007283]; unsaturated fatty acid metabolic process [GO:0033559]; very long-chain fatty acid metabolic process [GO:0000038]	acyl-CoA dehydrogenase activity [GO:0003995]; acyl-CoA oxidase activity [GO:0003997]; FAD binding [GO:0071949]; fatty acid binding [GO:0005504]; flavin adenine dinucleotide binding [GO:0050660]; palmitoyl-CoA oxidase activity [GO:0016401]; PDZ domain binding [GO:0030165]; protein N-terminus binding [GO:0047485]; receptor binding [GO:0005102]	intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; plasma membrane [GO:0005886]	GO:0071949; GO:0030165; GO:0003995; GO:0003997; GO:0036109; GO:0044255; GO:0033540; GO:0005504; GO:0019395; GO:0050660; GO:0006091; GO:0043231; GO:0055088; GO:0006629; GO:0016020; GO:0005739; GO:0005730; GO:0005654; GO:0005634; GO:0016401; GO:0005782; GO:0005778; GO:0005777; GO:0016559; GO:0005886; GO:2000189; GO:0006693; GO:0047485; GO:0005102; GO:0044281; GO:0007283; GO:0033559; GO:0000038	SUBCELLULAR LOCATION: Peroxisome.	Acetylation; Alternative splicing; Complete proteome; Disease mutation; FAD; Fatty acid metabolism; Flavoprotein; Lipid metabolism; Oxidoreductase; Peroxisome; Phosphoprotein; Polymorphism; Reference proteome	Active site (1); Alternative sequence (2); Binding site (2); Chain (1); Erroneous initiation (1); Modified residue (23); Motif (1); Natural variant (10); Sequence conflict (22)
E9PLB0_HUMAN	E9PLB0	E9PLB0_HUMAN	unreviewed	RNA-binding protein 4B	RBM4B	Homo sapiens (Human)	143	nucleic acid binding [GO:0003676]; nucleotide binding [GO:0000166]		nucleic acid binding [GO:0003676]; nucleotide binding [GO:0000166]		GO:0003676; GO:0000166		Complete proteome; Proteomics identification; Reference proteome	
D6R9K7_HUMAN	D6R9K7	D6R9K7_HUMAN	unreviewed	RNA-binding protein 4	RBM4	Homo sapiens (Human)	150	nucleic acid binding [GO:0003676]; nucleotide binding [GO:0000166]		nucleic acid binding [GO:0003676]; nucleotide binding [GO:0000166]		GO:0003676; GO:0000166		Complete proteome; Proteomics identification; Reference proteome	
ILF2_HUMAN	Q12905	ILF2_HUMAN	reviewed	Interleukin enhancer-binding factor 2 (Nuclear factor of activated T-cells 45 kDa)	ILF2 NF45 PRO3063	Homo sapiens (Human)	390	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; poly(A) RNA binding [GO:0044822]; transferase activity [GO:0016740]; immune response [GO:0006955]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]	immune response [GO:0006955]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription, DNA-templated [GO:0006351]	ATP binding [GO:0005524]; DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; poly(A) RNA binding [GO:0044822]; transferase activity [GO:0016740]	cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:0030529]	GO:0005524; GO:0003677; GO:0005737; GO:0003725; GO:0006955; GO:0016020; GO:0005730; GO:0005654; GO:0005634; GO:0044822; GO:0045893; GO:0030529; GO:0006351; GO:0016740	SUBCELLULAR LOCATION: Nucleus, nucleolus. Cytoplasm. Nucleus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.	Activator; Complete proteome; Cytoplasm; DNA-binding; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation	Chain (1); Compositional bias (2); Domain (1); Erroneous gene model prediction (1); Frameshift (1); Modified residue (1); Sequence caution (1)
H0YKK0_HUMAN	H0YKK0	H0YKK0_HUMAN	unreviewed	Small nuclear ribonucleoprotein polypeptide A', isoform CRA_a (U2 small nuclear ribonucleoprotein A')	SNRPA1 hCG_1992004	Homo sapiens (Human)	154	ribonucleoprotein complex [GO:0030529]; viral nucleocapsid [GO:0019013]			ribonucleoprotein complex [GO:0030529]; viral nucleocapsid [GO:0019013]	GO:0030529; GO:0019013		Complete proteome; Leucine-rich repeat; Proteomics identification; Reference proteome; Repeat; Ribonucleoprotein; Viral nucleoprotein; Virion	
Q5T5C7_HUMAN	Q5T5C7	Q5T5C7_HUMAN	unreviewed	Serine--tRNA ligase, cytoplasmic	SARS	Homo sapiens (Human)	536	cytoplasm [GO:0005737]; ATP binding [GO:0005524]; serine-tRNA ligase activity [GO:0004828]; seryl-tRNA aminoacylation [GO:0006434]	seryl-tRNA aminoacylation [GO:0006434]	ATP binding [GO:0005524]; serine-tRNA ligase activity [GO:0004828]	cytoplasm [GO:0005737]	GO:0005524; GO:0005737; GO:0004828; GO:0006434		Complete proteome; Proteomics identification; Reference proteome	
UGDH_HUMAN	O60701	UGDH_HUMAN	reviewed	UDP-glucose 6-dehydrogenase (UDP-Glc dehydrogenase) (UDP-GlcDH) (UDPGDH) (EC 1.1.1.22)	UGDH	Homo sapiens (Human)	494	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; electron carrier activity [GO:0009055]; NAD binding [GO:0051287]; UDP-glucose 6-dehydrogenase activity [GO:0003979]; cellular glucuronidation [GO:0052695]; gastrulation with mouth forming second [GO:0001702]; glycosaminoglycan biosynthetic process [GO:0006024]; small molecule metabolic process [GO:0044281]; UDP-glucose metabolic process [GO:0006011]; UDP-glucuronate biosynthetic process [GO:0006065]; xenobiotic metabolic process [GO:0006805]	cellular glucuronidation [GO:0052695]; gastrulation with mouth forming second [GO:0001702]; glycosaminoglycan biosynthetic process [GO:0006024]; small molecule metabolic process [GO:0044281]; UDP-glucose metabolic process [GO:0006011]; UDP-glucuronate biosynthetic process [GO:0006065]; xenobiotic metabolic process [GO:0006805]	electron carrier activity [GO:0009055]; NAD binding [GO:0051287]; UDP-glucose 6-dehydrogenase activity [GO:0003979]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]	GO:0051287; GO:0003979; GO:0006011; GO:0006065; GO:0052695; GO:0005829; GO:0009055; GO:0070062; GO:0001702; GO:0006024; GO:0005654; GO:0044281; GO:0006805		3D-structure; Acetylation; Allosteric enzyme; Alternative splicing; Complete proteome; NAD; Oxidoreductase; Phosphoprotein; Reference proteome	Active site (1); Alternative sequence (2); Beta strand (20); Binding site (5); Chain (1); Helix (20); Modified residue (2); Nucleotide binding (4); Region (4); Sequence conflict (2); Turn (6)
SRP14_HUMAN	P37108	SRP14_HUMAN	reviewed	Signal recognition particle 14 kDa protein (SRP14) (18 kDa Alu RNA-binding protein)	SRP14	Homo sapiens (Human)	136	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; nucleolus [GO:0005730]; nucleus [GO:0005634]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]; 7S RNA binding [GO:0008312]; endoplasmic reticulum signal peptide binding [GO:0030942]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]; cellular protein metabolic process [GO:0044267]; cotranslational protein targeting to membrane [GO:0006613]; gene expression [GO:0010467]; protein targeting to ER [GO:0045047]; response to drug [GO:0042493]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]	cellular protein metabolic process [GO:0044267]; cotranslational protein targeting to membrane [GO:0006613]; gene expression [GO:0010467]; protein targeting to ER [GO:0045047]; response to drug [GO:0042493]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]	7S RNA binding [GO:0008312]; endoplasmic reticulum signal peptide binding [GO:0030942]; poly(A) RNA binding [GO:0044822]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intercellular bridge [GO:0045171]; nucleolus [GO:0005730]; nucleus [GO:0005634]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]	GO:0008312; GO:0003723; GO:0006614; GO:0044267; GO:0006613; GO:0005737; GO:0005829; GO:0030942; GO:0070062; GO:0010467; GO:0045171; GO:0005730; GO:0005634; GO:0044822; GO:0045047; GO:0042493; GO:0005786; GO:0006412	SUBCELLULAR LOCATION: Cytoplasm.	3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Phosphoprotein; Polymorphism; RNA-binding; Reference proteome; Ribonucleoprotein; Signal recognition particle	Beta strand (3); Chain (1); Compositional bias (1); Helix (2); Initiator methionine (1); Modified residue (1); Natural variant (6); Sequence conflict (1); Turn (2)
SPSY_HUMAN	P52788	SPSY_HUMAN	reviewed	Spermine synthase (SPMSY) (EC 2.5.1.22) (Spermidine aminopropyltransferase)	SMS	Homo sapiens (Human)	366	cytosol [GO:0005829]; extracellular exosome [GO:0070062]; spermine synthase activity [GO:0016768]; cellular nitrogen compound metabolic process [GO:0034641]; methionine metabolic process [GO:0006555]; polyamine metabolic process [GO:0006595]; small molecule metabolic process [GO:0044281]; spermine biosynthetic process [GO:0006597]	cellular nitrogen compound metabolic process [GO:0034641]; methionine metabolic process [GO:0006555]; polyamine metabolic process [GO:0006595]; small molecule metabolic process [GO:0044281]; spermine biosynthetic process [GO:0006597]	spermine synthase activity [GO:0016768]	cytosol [GO:0005829]; extracellular exosome [GO:0070062]	GO:0034641; GO:0005829; GO:0070062; GO:0006555; GO:0006595; GO:0044281; GO:0006597; GO:0016768		3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Mental retardation; Polyamine biosynthesis; Polymorphism; Reference proteome; Transferase	Active site (1); Alternative sequence (1); Beta strand (19); Binding site (6); Chain (1); Domain (1); Helix (10); Initiator methionine (1); Modified residue (1); Mutagenesis (3); Natural variant (2); Region (1); Sequence conflict (1); Turn (3)
THIL_HUMAN	P24752	THIL_HUMAN	reviewed	Acetyl-CoA acetyltransferase, mitochondrial (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) (T2)	ACAT1 ACAT MAT	Homo sapiens (Human)	427	extracellular exosome [GO:0070062]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; acetyl-CoA C-acetyltransferase activity [GO:0003985]; coenzyme binding [GO:0050662]; metal ion binding [GO:0046872]; adipose tissue development [GO:0060612]; brain development [GO:0007420]; branched-chain amino acid catabolic process [GO:0009083]; cellular ketone body metabolic process [GO:0046950]; cellular lipid metabolic process [GO:0044255]; cellular nitrogen compound metabolic process [GO:0034641]; ketone body biosynthetic process [GO:0046951]; ketone body catabolic process [GO:0046952]; liver development [GO:0001889]; metanephric proximal convoluted tubule development [GO:0072229]; protein homooligomerization [GO:0051260]; response to hormone [GO:0009725]; response to organic cyclic compound [GO:0014070]; response to starvation [GO:0042594]; small molecule metabolic process [GO:0044281]	adipose tissue development [GO:0060612]; brain development [GO:0007420]; branched-chain amino acid catabolic process [GO:0009083]; cellular ketone body metabolic process [GO:0046950]; cellular lipid metabolic process [GO:0044255]; cellular nitrogen compound metabolic process [GO:0034641]; ketone body biosynthetic process [GO:0046951]; ketone body catabolic process [GO:0046952]; liver development [GO:0001889]; metanephric proximal convoluted tubule development [GO:0072229]; protein homooligomerization [GO:0051260]; response to hormone [GO:0009725]; response to organic cyclic compound [GO:0014070]; response to starvation [GO:0042594]; small molecule metabolic process [GO:0044281]	acetyl-CoA C-acetyltransferase activity [GO:0003985]; coenzyme binding [GO:0050662]; metal ion binding [GO:0046872]	extracellular exosome [GO:0070062]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0003985; GO:0060612; GO:0007420; GO:0009083; GO:0046950; GO:0044255; GO:0034641; GO:0050662; GO:0070062; GO:0046951; GO:0046952; GO:0001889; GO:0046872; GO:0072229; GO:0005743; GO:0005759; GO:0005739; GO:0051260; GO:0009725; GO:0014070; GO:0042594; GO:0044281	SUBCELLULAR LOCATION: Mitochondrion.	3D-structure; Acetylation; Acyltransferase; Alternative splicing; Complete proteome; Direct protein sequencing; Disease mutation; Metal-binding; Mitochondrion; Polymorphism; Potassium; Reference proteome; Transferase; Transit peptide	Active site (3); Alternative sequence (2); Beta strand (15); Binding site (3); Chain (1); Helix (19); Metal binding (5); Modified residue (24); Natural variant (12); Region (1); Sequence conflict (4); Transit peptide (1); Turn (7)
SSDH_HUMAN	P51649	SSDH_HUMAN	reviewed	Succinate-semialdehyde dehydrogenase, mitochondrial (EC 1.2.1.24) (Aldehyde dehydrogenase family 5 member A1) (NAD(+)-dependent succinic semialdehyde dehydrogenase)	ALDH5A1 SSADH	Homo sapiens (Human)	535	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; aldehyde dehydrogenase (NAD) activity [GO:0004029]; protein homodimerization activity [GO:0042803]; succinate-semialdehyde dehydrogenase (NAD+) activity [GO:0004777]; succinate-semialdehyde dehydrogenase [NAD(P)+] activity [GO:0009013]; acetate metabolic process [GO:0006083]; central nervous system development [GO:0007417]; galactosylceramide metabolic process [GO:0006681]; gamma-aminobutyric acid catabolic process [GO:0009450]; glucose metabolic process [GO:0006006]; glucosylceramide metabolic process [GO:0006678]; glutamate metabolic process [GO:0006536]; glutamine metabolic process [GO:0006541]; glutathione metabolic process [GO:0006749]; glycerophospholipid metabolic process [GO:0006650]; neurotransmitter catabolic process [GO:0042135]; neurotransmitter secretion [GO:0007269]; post-embryonic development [GO:0009791]; protein homotetramerization [GO:0051289]; respiratory electron transport chain [GO:0022904]; short-chain fatty acid metabolic process [GO:0046459]; succinate metabolic process [GO:0006105]; synaptic transmission [GO:0007268]	acetate metabolic process [GO:0006083]; central nervous system development [GO:0007417]; galactosylceramide metabolic process [GO:0006681]; gamma-aminobutyric acid catabolic process [GO:0009450]; glucose metabolic process [GO:0006006]; glucosylceramide metabolic process [GO:0006678]; glutamate metabolic process [GO:0006536]; glutamine metabolic process [GO:0006541]; glutathione metabolic process [GO:0006749]; glycerophospholipid metabolic process [GO:0006650]; neurotransmitter catabolic process [GO:0042135]; neurotransmitter secretion [GO:0007269]; post-embryonic development [GO:0009791]; protein homotetramerization [GO:0051289]; respiratory electron transport chain [GO:0022904]; short-chain fatty acid metabolic process [GO:0046459]; succinate metabolic process [GO:0006105]; synaptic transmission [GO:0007268]	aldehyde dehydrogenase (NAD) activity [GO:0004029]; protein homodimerization activity [GO:0042803]; succinate-semialdehyde dehydrogenase (NAD+) activity [GO:0004777]; succinate-semialdehyde dehydrogenase [NAD(P)+] activity [GO:0009013]	mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]	GO:0006083; GO:0004029; GO:0007417; GO:0006681; GO:0009450; GO:0006006; GO:0006678; GO:0006536; GO:0006541; GO:0006749; GO:0006650; GO:0005759; GO:0005739; GO:0042135; GO:0007269; GO:0009791; GO:0042803; GO:0051289; GO:0022904; GO:0046459; GO:0006105; GO:0004777; GO:0009013; GO:0007268	SUBCELLULAR LOCATION: Mitochondrion.	3D-structure; Acetylation; Alternative splicing; Complete proteome; Disease mutation; Disulfide bond; Mitochondrion; NAD; Oxidoreductase; Phosphoprotein; Polymorphism; Reference proteome; Transit peptide	Active site (2); Alternative sequence (1); Beta strand (23); Binding site (4); Chain (1); Disulfide bond (1); Helix (18); Modified residue (10); Mutagenesis (4); Natural variant (18); Nucleotide binding (2); Site (1); Transit peptide (1); Turn (5)
PP1R8_HUMAN	Q12972	PP1R8_HUMAN	reviewed	Nuclear inhibitor of protein phosphatase 1 (NIPP-1) (Protein phosphatase 1 regulatory inhibitor subunit 8) [Includes: Activator of RNA decay (EC 3.1.4.-) (ARD-1)]	PPP1R8 ARD1 NIPP1	Homo sapiens (Human)	351	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; protein phosphatase type 1 regulator activity [GO:0008599]; protein serine/threonine phosphatase inhibitor activity [GO:0004865]; ribonuclease E activity [GO:0008995]; RNA binding [GO:0003723]; cell proliferation [GO:0008283]; mRNA processing [GO:0006397]; negative regulation of catalytic activity [GO:0043086]; regulation of transcription, DNA-templated [GO:0006355]; RNA catabolic process [GO:0006401]; RNA phosphodiester bond hydrolysis [GO:0090501]; RNA splicing [GO:0008380]; transcription, DNA-templated [GO:0006351]	cell proliferation [GO:0008283]; mRNA processing [GO:0006397]; negative regulation of catalytic activity [GO:0043086]; regulation of transcription, DNA-templated [GO:0006355]; RNA catabolic process [GO:0006401]; RNA phosphodiester bond hydrolysis [GO:0090501]; RNA splicing [GO:0008380]; transcription, DNA-templated [GO:0006351]	DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; protein phosphatase type 1 regulator activity [GO:0008599]; protein serine/threonine phosphatase inhibitor activity [GO:0004865]; ribonuclease E activity [GO:0008995]; RNA binding [GO:0003723]	cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]	GO:0003677; GO:0003723; GO:0006401; GO:0090501; GO:0008380; GO:0008283; GO:0005737; GO:0004519; GO:0006397; GO:0043086; GO:0016607; GO:0005654; GO:0005634; GO:0008599; GO:0004865; GO:0006355; GO:0008995; GO:0005681; GO:0006351	SUBCELLULAR LOCATION: Nucleus. Nucleus speckle. Note=Primarily, but not exclusively, nuclear.; SUBCELLULAR LOCATION: Isoform Gamma: Cytoplasm. Note=Found mainly in the cytoplasm.	3D-structure; Alternative splicing; Complete proteome; Cytoplasm; DNA-binding; Endonuclease; Hydrolase; Magnesium; Nuclease; Nucleus; Phosphoprotein; Protein phosphatase inhibitor; RNA-binding; Reference proteome; Repeat; Repressor; Spliceosome; Transcription; Transcription regulation; mRNA processing; mRNA splicing	Alternative sequence (2); Beta strand (1); Chain (1); Domain (1); Helix (1); Modified residue (5); Motif (2); Mutagenesis (12); Region (7)
DDX46_HUMAN	Q7L014	DDX46_HUMAN	reviewed	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.4.13) (DEAD box protein 46) (PRP5 homolog)	DDX46 KIAA0801	Homo sapiens (Human)	1031	Cajal body [GO:0015030]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ATP-dependent RNA helicase activity [GO:0004004]; poly(A) RNA binding [GO:0044822]; mRNA splicing, via spliceosome [GO:0000398]; regulation of gene expression [GO:0010468]; RNA secondary structure unwinding [GO:0010501]	mRNA splicing, via spliceosome [GO:0000398]; regulation of gene expression [GO:0010468]; RNA secondary structure unwinding [GO:0010501]	ATP binding [GO:0005524]; ATP-dependent RNA helicase activity [GO:0004004]; poly(A) RNA binding [GO:0044822]	Cajal body [GO:0015030]; nuclear speck [GO:0016607]; nucleus [GO:0005634]	GO:0005524; GO:0004004; GO:0015030; GO:0010501; GO:0000398; GO:0016607; GO:0005634; GO:0044822; GO:0010468	SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:12234937}. Nucleus, Cajal body {ECO:0000269|PubMed:12234937}. Note=Present in Cajal bodies (CBs) and nuclear speckles.	ATP-binding; Acetylation; Coiled coil; Complete proteome; Helicase; Hydrolase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; RNA-binding; Reference proteome; mRNA processing; mRNA splicing	Chain (1); Coiled coil (1); Compositional bias (2); Domain (2); Erroneous initiation (1); Modified residue (7); Motif (2); Natural variant (1); Nucleotide binding (1); Sequence conflict (10)
B4DDP6_HUMAN	B4DDP6	B4DDP6_HUMAN		Merged into Q9UJU6.											
LSM2_HUMAN	Q9Y333	LSM2_HUMAN	reviewed	U6 snRNA-associated Sm-like protein LSm2 (Protein G7b) (Small nuclear ribonuclear protein D homolog) (snRNP core Sm-like protein Sm-x5)	LSM2 C6orf28 G7B	Homo sapiens (Human)	95	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; poly(A) RNA binding [GO:0044822]; Ral GTPase binding [GO:0017160]; U6 snRNA binding [GO:0017070]; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [GO:0043928]; gene expression [GO:0010467]; mRNA splicing, via spliceosome [GO:0000398]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; RNA splicing [GO:0008380]	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [GO:0043928]; gene expression [GO:0010467]; mRNA splicing, via spliceosome [GO:0000398]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; RNA splicing [GO:0008380]	poly(A) RNA binding [GO:0044822]; Ral GTPase binding [GO:0017160]; U6 snRNA binding [GO:0017070]	catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]	GO:0008380; GO:0017160; GO:0017070; GO:0071013; GO:0005829; GO:0043928; GO:0010467; GO:0000398; GO:0000288; GO:0005654; GO:0044822	SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.	Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein; RNA-binding; Reference proteome; Ribonucleoprotein; Spliceosome; mRNA processing; mRNA splicing	Chain (1); Modified residue (1)
